CN103071111A - Medicine composition for curing angina pectoris and preparation method of pharmaceutical composition - Google Patents
Medicine composition for curing angina pectoris and preparation method of pharmaceutical composition Download PDFInfo
- Publication number
- CN103071111A CN103071111A CN 201210596936 CN201210596936A CN103071111A CN 103071111 A CN103071111 A CN 103071111A CN 201210596936 CN201210596936 CN 201210596936 CN 201210596936 A CN201210596936 A CN 201210596936A CN 103071111 A CN103071111 A CN 103071111A
- Authority
- CN
- China
- Prior art keywords
- angina pectoris
- radix
- chinese medicine
- coronary heart
- curing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pharmaceutical composition for curing angina pectoris. The pharmaceutical composition is composed of folium ginkgo bilobae, trichosanthes kirilowii maxim, the root of red-rooted salvia, fragrant-flowered garlic stem, radix curcumae and liquorice. The medicine has the efficacies of curing both symptoms and root causes, and stopping pain and removing arthralgia; and compared with other new traditional Chinese medicine, the medicine has the advantages of tonifying the kidney, strengthening the heart, nourishing the kidney and the heart, curing angina pectoris while reducing blood sugar, and preventing and curing HLP (hyperlipidaemia), and has a unique curative effect and obvious efficacy for old patients suffering with coronary heart diseases associated with high blood pressure, HLP or diabetes mellitus.
Description
Technical field
The present invention relates to tcm field, be specifically related to a kind for the treatment of coronary heart disease and angina pectoris composition and method of making the same for the treatment of.
Background technology
Along with the development of society, the improving constantly of the progress of material progress and medical science level, the disease of many harm people's life health has obtained effective control.Yet the existence of the factors such as the generally raising in people's life-span and smoking, high fat diet, obesity, the sickness rate of cardiovascular disease rises relatively, coronary heart disease especially, and the Angina rate is higher, hazardness is larger, and the serious life and health that is threatening people.In recent years in the new Chinese medicine of the treatment angina pectoris of Ministry of Public Health approval listing mainly with invigorating blood circulation addiction; the regulating QI to relieve pain therapy is main; such as DIAOXINXUE KANG, Salvia Miltiorrhiza Oral Liquid, FUFANG DANSHEN JIAONANG, XINTONGKOU PIAN, BUXINQI KOUFUYE, taste the heart-yin oral liquid, Yiqi oral liquid etc.; and clinical research shows that heart deficiency of the kidney yin is year high common etiology and pathogenesis of people; singly executing tired the invigorating blood circulation of dispelling is in fear of just hindering; if and with nourishing kidney nourish heart Yu among; both prevented hindering fraud just; cardiorenal function two be can strengthen again and invigorating blood circulation addiction, promoting the circulation of QI to relieve pain more helped.
Summary of the invention
The invention provides a kind for the treatment of coronary heart disease and angina pectoris composition and method of making the same for the treatment of.
A kind for the treatment of coronary heart disease and angina pectoris compositions for the treatment of that the present invention proposes comprises Folium Ginkgo, Fructus Trichosanthis, Radix Salviae Miltiorrhizae, JIUBAI, Radix Curcumae, Radix Glycyrrhizae; Raw material of Chinese medicine by the following weight ratio is made: Folium Ginkgo 5-50 part, Fructus Trichosanthis 5-50 part, Radix Salviae Miltiorrhizae 5-50 part, JIUBAI 5-30 part, Radix Curcumae 10-30 part, Radix Glycyrrhizae 2-10 part.
Among the present invention, described treatment treating coronary heart disease and angina pectoris compositions is made by the raw material of Chinese medicine of following weight ratio: 15 parts of Folium Ginkgos, 15 parts of Fructus Trichosanthis, 15 parts of Radix Salviae Miltiorrhizaes, 12 parts of JIUBAI, 10 parts of Radix Curcumaes, 4.5 parts in Radix Glycyrrhizae.
Among the present invention, described treatment treating coronary heart disease and angina pectoris compositions is oral formulations.
Among the present invention, described treatment treating coronary heart disease and angina pectoris compositions, a preferred oral formulations dosage form is decoction.
Among the present invention, the preparation method of described treatment treating coronary heart disease and angina pectoris compositions, described preparation method process following steps,
(1) take by weighing the raw material of Chinese medicine of described part by weight, be ground into the Chinese medicine coarse powder, for subsequent use;
(2) the Chinese medicine coarse powder with gained in the step (1) adds 5-10 times of water gaging decoction, filter, both.
Folium Ginkgo nature and flavor: hardship; Sweet; Puckery; Property is put down; Mild toxicity.Gui Jing: the heart; Lung; Spleen channel.Function cures mainly: invigorate blood circulation and nourish heart, the astringing intestine to stop diarrhea of astringing the lung.Main obstruction of qi in the chest and cardialgia; The phlegmatic cough of breathing with cough; Dysentery; Leucorrhea.Folium Ginkgo contains the composition that flavone compound belongs to flavonoid and glycoside thereof nimbecetin; luteolin; myricetin; Quercetin; isorhamnetin; the Flos Caryophylli flavin; Kaempferol-Fructus rhamni (Rhamnus davurica Pall.) glycoside; (6-is to coumaric acyl glucosyl group-β-1 for Kaempferol; the 4-rhamnoside; Kaempferol-O-(2-O-β-D-glucopyranosyl)-α-L-pyrans rhamnoside; Kaempferol-O-[2-O-6-O-[p-(7-O-β-D-glucopyranosyl) coumaric acyl]-β-D-glucopyranosyl]-α-L-pyrans rhamnoside.
The Fructus Trichosanthis nature and flavor with return through: cold in nature, sweet in the mouth, little hardship.Return lung, stomach, large intestine channel.Cure mainly: clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens is moisturized laxation.Be used for the cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, and the blocked-up chest feeling of fullness, acute mastitis, lung abscess, acute appendicitis swells and ache, constipation.Fruit contains triterpenoid saponin, organic acid, resin, saccharide and pigment.Contained protein is different from contained protein in its tuber " Radix Trichosanthis " in the fruit, without the induction of labour in second trimester effect.Pericarpium Trichosanthis contains a small amount of volatile oil.Wherein acidic moiety has n-nonanoic acid, capric acid, lauric acid, myristic acid, Pentadecane acid, palmitoleic acid, Palmic acid, linoleic acid, linolenic acid, stearic acid, divergent chain tetradecanoic acid, three kind of 15 divergent chain carbon alkanoic acid and divergent chain hexadecanoic acid.Content with Palmic acid, linoleic acid plus linolenic acid is the highest.
The Radix Salviae Miltiorrhizae meridian distribution of property and flavor: hardship is slightly cold.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Cure mainly: menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Use: be used for the costa sternales hypochondriac pain, rheumatic arthralgia, the lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect, normal and the application of Rhizoma Chuanxiong compatibility.Belong to aspect the qi depression to blood stasis in treatment breast abdomen pain, often cooperate the medicines such as Fructus Amomi, Lignum Santali Albi with using.The root master contains the diterpene Quinone Pigments, Tanshinone I, IIA, IIB, cryptotanshinone, iso tanshinone I, II, different cryptotanshinone, miltirone, Methyl tanshinoate, hydroxyl tanshinone ⅡA, dihydrotanshinone I, neotanshinone A, second, the third, methylene tanshinquinone and carnosol.Report closes ferruginal, Δ 1-miltirone, Δ 1-tanshinone ⅡA, danshenxinkun fourth and 1,2-dihydro Radix Salviae Miltiorrhizae quinone etc. in addition.Except diterpene quinone, still close protocatechualdehyde, cupreol and D (+) β-lactic acid, and contracting carboxylic acid compound A, E etc.
The Radix Curcumae nature and flavor with return through: hot, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.Contain volatile oil, camphene, Camphora, curcumene are wherein arranged; Also contain curcumin, demethoxycurcumin, bisdemethoxycurcumin, turmerone and aryl turmerone.Still contain starch, fatty oil, rubber, weld, Eucarvone and phellandrene.
The Radix Glycyrrhizae nature and flavor: sweet in the mouth is flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function with cure mainly: spleen reinforcing stomach function regulating, Yiqi and vein recovery.Be used for weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse can be separated the Radix Aconiti Lateralis Preparata poison.The Radix Glycyrrhizae Preparata clinical practice mostly is zhigancao decoction, is the soup of making take Radix Glycyrrhizae Preparata as primary raw material.Come from Han dynasty Zhang Zhongjing treatise on Febrile Diseases, original text is said: " typhoid fever, irregularly intermittent and regularly intermittent pulse, severe palpitation, the zhigancao decoction master it." formed by Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Recens, Ramulus Cinnamomi, Radix Ginseng, the Radix Rehmanniae, Colla Corii Asini, Radix Ophiopogonis, Fructus Cannabis, Fructus Jujubae, rice wine.Comprehensive ancient Chinese medicine doctor view, think that the main effect of zhigancao decoction has: 1, nourishing YIN is main, as clear Ke Qin " the attached wing of renewal of treatise on febrile disease typhoid fever " point out we take " Radix Rehmanniae for monarch, Radix Ophiopogonis as minister, Radix Glycyrrhizae Preparata for helping, agent is Kidney-Yin with high benefit greatly, the YIN nourishing one tunnel of come also." clear Tian Zonghan " doctor posts excellent cloudy opinion " thinks that also we are " the ancestral sides of the YIN nourishing ".2, it is main enriching blood, and thinks that such as one doctor take clear Tang Rong river as representative zhigancao decoction is " enriching blood big dose ".3, qi and blood tonifying as take golden Cheng Wuji " Treatise on Febrile Disease with Notes " as representative, thinks that the effect of zhigancao decoction ought be qi and blood tonifying." beneficial void enrich blood gas and multiple arteries and veins ".4, negative and positive and accent, the doctor of Qing Dynasty You Zaijing " typhoid fever string of pearls collection " point out that zhigancao decoction is " system in the enlarging is the methods of negative and positive and accent ".We cure mainly behind the typhoid or severe disease convalescent period deficiency of YIN-blood, the not flourish heart of blood, and the weakness with emaciation weak breath, nervous cardiopalmus, fidgets due to deficiency is slept less, defecates dry and astringent, the slightly red few tongue of body of the tongue, the pulse condition knot is not for whole.Or the consumptive lung disease chronic cough, the rare expectorant of salivation, amount is many, parched throat and thirsty, or sputum mixed with blood, shortness of breath and palpitation, warm liquid liquid in the heart, insomnia hyperhidrosis, deficient and thready pulse and counting, or accidental knot generation.
Product of the present invention has giving consideration to both the incidental and fundamental, the effect of pain relieving benefit numbness, comparing the most outstanding advantage with new Chinese medicine of other treatment angina pectoris is can tonifying kidneys, strengthening heart, nourish heart by the nourishing kidney of invigorating blood circulation addiction, at blood sugar lowering, treatment angina pectoris when preventing and treating hyperlipemia, especially to the gerontal patient special effect of coronary heart disease with hypertension, hyperlipemia or diabetes, effect is remarkable.Its function cures mainly and is blood circulation promoting regulates qi, nourishing kidney yin.Be used for the angina pectoris stagnation of QI blood addiction deficiency of kidney yin card of holding concurrently, that disease is seen is uncomfortable in chest, chest pain, cardiopalmus, dizziness, insomnia, tinnitus, soreness of the waist and knees.
Using method: every day is each potion sooner or later.
The specific embodiment
Below in conjunction with embodiment the present invention is described.
Embodiment 1.
Among the present invention, described a kind for the treatment of coronary heart disease and angina pectoris composition and method of making the same for the treatment of comprises the steps:
(1) weighting raw materials: Folium Ginkgo 15g, Fructus Trichosanthis 15g, Radix Salviae Miltiorrhizae 15g, JIUBAI 12g, Radix Curcumae 10g, Radix Glycyrrhizae 4.5g, be ground into the Chinese medicine coarse powder, for subsequent use;
(2) the Chinese medicine coarse powder with gained in the step (1) adds 8 times of water gagings decoctions, filter, both.
Embodiment 2.
Among the present invention, described a kind for the treatment of coronary heart disease and angina pectoris composition and method of making the same for the treatment of comprises the steps:
(1) weighting raw materials: Folium Ginkgo 15g, Fructus Trichosanthis 15g, Radix Salviae Miltiorrhizae 15g, JIUBAI 12g, Radix Curcumae 10g, Radix Glycyrrhizae 4.5g, be ground into the Chinese medicine coarse powder, for subsequent use;
(2) the Chinese medicine coarse powder with gained in the step (1) adds 5 times of water gagings decoctions, filter, both.
Case: product of the present invention from January, 2005 to 2010 year December observe altogether case 60 examples, test group 30 examples wherein, matched group 30 examples, the result shows, test group angina pectoris obvious effective rate is 50, and total effective rate is 90, the tcm syndrome obvious effective rate is 66.7, total effective rate is 93.8, compares with matched group, and the P value all＞0.05.
The above; only be the better specific embodiment of the present invention; but protection scope of the present invention is not limited to this; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to replacement or change according to technical scheme of the present invention and inventive concept thereof, all should be encompassed within protection scope of the present invention.
Claims (5)
1. a treatment treating coronary heart disease and angina pectoris compositions is characterized in that: comprise Folium Ginkgo, Fructus Trichosanthis, Radix Salviae Miltiorrhizae, JIUBAI, Radix Curcumae, Radix Glycyrrhizae; Raw material of Chinese medicine by the following weight ratio is made: Folium Ginkgo 5-50 part, Fructus Trichosanthis 5-50 part, Radix Salviae Miltiorrhizae 5-50 part, JIUBAI 5-30 part, Radix Curcumae 10-30 part, Radix Glycyrrhizae 2-10 part.
2. treatment treating coronary heart disease and angina pectoris compositions according to claim 1, it is characterized in that: the raw material of Chinese medicine by the following weight ratio is made: 15 parts of Folium Ginkgos, 15 parts of Fructus Trichosanthis, 15 parts of Radix Salviae Miltiorrhizaes, 12 parts of JIUBAI, 10 parts of Radix Curcumaes, 4.5 parts in Radix Glycyrrhizae.
3. treatment treating coronary heart disease and angina pectoris compositions according to claim 1 is characterized in that: be oral formulations.
4. treatment treating coronary heart disease and angina pectoris compositions according to claim 3, it is characterized in that: a preferred oral formulations dosage form is decoction.
5. the preparation method for the treatment of treating coronary heart disease and angina pectoris compositions according to claim 4 is characterized in that: described preparation method is through following steps,
(1) take by weighing the raw material of Chinese medicine of described part by weight, be ground into the Chinese medicine coarse powder, for subsequent use;
(2) the Chinese medicine coarse powder with gained in the step (1) adds 5-10 times of water gaging decoction, filter, both.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210596936 CN103071111A (en) | 2012-12-26 | 2012-12-26 | Medicine composition for curing angina pectoris and preparation method of pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210596936 CN103071111A (en) | 2012-12-26 | 2012-12-26 | Medicine composition for curing angina pectoris and preparation method of pharmaceutical composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103071111A true CN103071111A (en) | 2013-05-01 |
Family
ID=48147956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210596936 Pending CN103071111A (en) | 2012-12-26 | 2012-12-26 | Medicine composition for curing angina pectoris and preparation method of pharmaceutical composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103071111A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316302A (en) * | 2013-07-08 | 2013-09-25 | 陈静静 | Chinese medicine formula for treating angina pectoris |
| CN105214001A (en) * | 2015-11-09 | 2016-01-06 | 山东省立医院 | A kind of Chinese medicine composition for the treatment of hypertensive patients coronary heart disease |
| CN105434788A (en) * | 2015-12-17 | 2016-03-30 | 李慧 | Traditional Chinese medicine used for treating coronary heart disease angina in anesthesia department, and preparation method thereof |
-
2012
- 2012-12-26 CN CN 201210596936 patent/CN103071111A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316302A (en) * | 2013-07-08 | 2013-09-25 | 陈静静 | Chinese medicine formula for treating angina pectoris |
| CN105214001A (en) * | 2015-11-09 | 2016-01-06 | 山东省立医院 | A kind of Chinese medicine composition for the treatment of hypertensive patients coronary heart disease |
| CN105214001B (en) * | 2015-11-09 | 2019-03-08 | 山东省立医院 | A kind of Chinese medicine composition for treating hypertensive patients coronary heart disease |
| CN105434788A (en) * | 2015-12-17 | 2016-03-30 | 李慧 | Traditional Chinese medicine used for treating coronary heart disease angina in anesthesia department, and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102100856A (en) | Nano traditional Chinese medicine for treating bronchial asthma and preparation technology | |
| CN108030864A (en) | A kind of strong medicine liquid for treating traumatic injury, burn and inflammation | |
| CN102698216B (en) | Formula and preparation method of medicament for preventing and treating cold and cough | |
| CN103071111A (en) | Medicine composition for curing angina pectoris and preparation method of pharmaceutical composition | |
| CN101690787B (en) | Traditional Chinese medicine for treating chronic gastritis and gastric ulcer | |
| CN102631463A (en) | Traditional Chinese medicine (TCM) for treating delayed encephalopathy after acute carbon monoxide poisoning | |
| CN102579799A (en) | Traditional Chinese medicine composition for treating postpartum fever with blood deficiency | |
| CN106421335A (en) | Compound medicine for treating chronic pharyngitis | |
| CN102727846B (en) | Traditional Chinese medicine decoction used for treating common cold, and preparation method thereof | |
| CN105250968A (en) | Traditional Chinese medicine preparation for treating asthma | |
| CN104840773A (en) | Traditional Chinese medicine composition for treating vertebral artery type cervical spondylopathy and method for preparing same | |
| CN105617146A (en) | Traditional Chinese medicine composition for preventing and treating infantile recurrent respiratory tract infection and preparation method thereof | |
| CN103055292A (en) | Gallbladder heat medicine composition and preparation method thereof | |
| CN105796685A (en) | Method for preparing traditional Chinese medicine composition for treating myocardial infarction | |
| CN104758676A (en) | Medicine for treating damp-heat in resistance-type epigastric pain | |
| CN104258224A (en) | Schisandra chinensis oral solution for treating lung-and-kidney yin-deficiency type chronic bronchitis and preparation method thereof | |
| CN108159257A (en) | Treat Chinese medicine composition of chronic enteritis and preparation method thereof | |
| CN103417914A (en) | TCM composition for treatment of acute renal failure | |
| CN105998979A (en) | Traditional Chinese medicine composition for treating lung-and-kidney-yin-deficiency-type chronic pharyngitis and method | |
| CN105770760A (en) | Preparation for treating gastric ulcer and preparation method thereof | |
| CN1067883C (en) | Traditional Chinese medicine for treating liver cirrhosis and preparation method thereof | |
| CN107929593B (en) | Medicament for treating children cough | |
| CN103768376B (en) | A kind of composition of medicine treating diabetes and preparation method | |
| CN118286374A (en) | A medicinal ointment for treating qi deficiency and blood stasis, and its preparation method | |
| CN104435162A (en) | Oral traditional Chinese medicine preparation for treating viral pneumonia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Lin Yang Document name: Notification of before Expiration of Request of Examination as to Substance |
|
| DD01 | Delivery of document by public notice |
Addressee: Lin Yang Document name: Notification that Application Deemed to be Withdrawn |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130501 |