CN107207587B - 人源化抗-补体因子c1q抗体及其应用 - Google Patents

人源化抗-补体因子c1q抗体及其应用 Download PDF

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CN107207587B
CN107207587B CN201580072390.6A CN201580072390A CN107207587B CN 107207587 B CN107207587 B CN 107207587B CN 201580072390 A CN201580072390 A CN 201580072390A CN 107207587 B CN107207587 B CN 107207587B
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antibody
antigen
amino acid
binding fragment
seq
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CN107207587A (zh
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A·罗森塔尔
M·立维腾
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Annexon Inc
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CN201580072390.6A 2014-11-05 2015-11-05 人源化抗-补体因子c1q抗体及其应用 Active CN107207587B (zh)

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US201462075793P 2014-11-05 2014-11-05
US62/075,793 2014-11-05
PCT/US2015/059185 WO2016073685A1 (en) 2014-11-05 2015-11-05 Humanized anti-complement factor c1q antibodies and uses thereof

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CN107207587B true CN107207587B (zh) 2022-04-19

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EP2996722A4 (en) * 2013-05-15 2017-01-11 Annexon, Inc. Methods of treatment for guillain-barre syndrome
EP3019240B1 (en) 2013-07-09 2024-03-13 Annexon, Inc. Anti-complement factor c1q antibodies and uses thereof
WO2017091719A1 (en) * 2015-11-24 2017-06-01 Annexon, Inc. Anti-complement factor c1q fab fragments and uses thereof
WO2017196874A1 (en) * 2016-05-09 2017-11-16 Annexon, Inc. Compositions and methods for treating spinal muscular atrophy
CA3030872A1 (en) * 2016-07-19 2018-01-25 Annexon, Inc. Compositions and methods for treating frontotemporal dementia
US20190248885A1 (en) * 2016-10-26 2019-08-15 The Board Of Trustees Of The Leland Stanford Junior University Neuronal and Oligodendrocyte Survival Modulation
US11372001B2 (en) * 2017-07-06 2022-06-28 Nitto Boseki Co., Ltd. Anti-human IgG4 monoclonal antibody and methods of making and using same
CN111556895B (zh) * 2017-11-14 2024-09-13 中外制药株式会社 抗-c1s抗体及使用方法
MA52248A (fr) * 2018-04-13 2021-02-17 Chugai Pharmaceutical Co Ltd Anticorps dirigés contre un composant du complément et procédés d'utilisation
MX2021004819A (es) * 2018-11-02 2021-06-08 Annexon Inc Composiciones y metodos para tratar lesiones cerebrales.
KR102662915B1 (ko) * 2018-11-22 2024-05-03 쑤저우 카노바 바이오파마슈티컬 컴퍼니 리미티드 항-b7-h3 항체
US11161900B2 (en) 2018-12-13 2021-11-02 Argenx Bvba Antibodies that specifically bind to human complement factor C2b
CN110297093B (zh) * 2019-03-18 2022-04-22 山西瑞豪生物科技有限公司 一种检测人免疫球蛋白g4的方法和试剂盒
US12473353B2 (en) 2019-05-15 2025-11-18 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule, a pharmaceutical composition, and a method
GB2584105B (en) * 2019-05-21 2023-08-02 Argenx Bvba Methods of treating neuropathy
WO2021076991A1 (en) * 2019-10-17 2021-04-22 Annexon, Inc. Compositions and methods for treating blood disorders
MX2022013927A (es) * 2020-05-05 2022-11-30 The J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Glads Composiciones y metodos para tratar la epilepsia.
CA3195798A1 (en) * 2020-10-16 2022-04-21 Ted Yednock Compositions and methods for treating blood disorders
JP2024513837A (ja) 2021-03-31 2024-03-27 バイオベラティブ・ユーエスエイ・インコーポレイテッド 寒冷凝集素症患者における手術関連溶血の低減
GB202113674D0 (en) 2021-09-24 2021-11-10 Reflection Therapeutics Ltd Targeted cell therapies
GB202113673D0 (en) 2021-09-24 2021-11-10 Reflection Therapeutics Ltd Targeted cell therapies
US12486322B2 (en) * 2021-12-13 2025-12-02 Annexon, Inc. Anti-complement factor C1q antibodies with single binding arms and uses thereof
WO2023126821A1 (en) * 2021-12-29 2023-07-06 Curateq Biologics Private Limited C1q binding assay
CN117085132A (zh) * 2022-05-20 2023-11-21 浙江大学 阻断胸膜间皮细胞cd93的活性物质及应用
CN119371528B (zh) * 2024-10-30 2025-06-24 泰州市人民医院 一种C1q抗体及其应用、一种抑制补体经典途径活化的药剂及其应用

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