AU2015343029B2 - Humanized anti-complement factor C1q antibodies and uses thereof - Google Patents

Humanized anti-complement factor C1q antibodies and uses thereof Download PDF

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AU2015343029B2
AU2015343029B2 AU2015343029A AU2015343029A AU2015343029B2 AU 2015343029 B2 AU2015343029 B2 AU 2015343029B2 AU 2015343029 A AU2015343029 A AU 2015343029A AU 2015343029 A AU2015343029 A AU 2015343029A AU 2015343029 B2 AU2015343029 B2 AU 2015343029B2
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antibody
amino acid
acid sequence
seq
antigen
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AU2015343029A1 (en
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Michael Leviten
Arnon Rosenthal
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Annexon Inc
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Annexon Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K—PEPTIDES
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a

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  • Biochemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
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  • Diabetes (AREA)
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AU2015343029A 2014-11-05 2015-11-05 Humanized anti-complement factor C1q antibodies and uses thereof Active AU2015343029B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462075793P 2014-11-05 2014-11-05
US62/075,793 2014-11-05
PCT/US2015/059185 WO2016073685A1 (en) 2014-11-05 2015-11-05 Humanized anti-complement factor c1q antibodies and uses thereof

Publications (2)

Publication Number Publication Date
AU2015343029A1 AU2015343029A1 (en) 2017-06-15
AU2015343029B2 true AU2015343029B2 (en) 2021-07-29

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AU2015343029A Active AU2015343029B2 (en) 2014-11-05 2015-11-05 Humanized anti-complement factor C1q antibodies and uses thereof

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US (4) US10316081B2 (enExample)
EP (2) EP4295911A3 (enExample)
JP (2) JP6951246B2 (enExample)
KR (1) KR102626877B1 (enExample)
CN (1) CN107207587B (enExample)
AU (1) AU2015343029B2 (enExample)
BR (1) BR112017009297B1 (enExample)
CA (1) CA2966894A1 (enExample)
DK (1) DK3215527T3 (enExample)
ES (1) ES3013108T3 (enExample)
FI (1) FI3215527T3 (enExample)
HR (1) HRP20250246T1 (enExample)
HU (1) HUE070383T2 (enExample)
IL (1) IL252026B (enExample)
LT (1) LT3215527T (enExample)
PL (1) PL3215527T3 (enExample)
PT (1) PT3215527T (enExample)
RS (1) RS66604B1 (enExample)
SG (2) SG11201703667SA (enExample)
SI (1) SI3215527T1 (enExample)
SM (1) SMT202500118T1 (enExample)
WO (1) WO2016073685A1 (enExample)

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EP2997045A4 (en) * 2013-05-15 2016-11-23 Annexon Inc ANTI-FACTOR C1S ANTIBODIES OF THE COMPLEMENT AND USES THEREOF
HUE066722T2 (hu) 2013-07-09 2024-09-28 Annexon Inc C1Q anti-komplement faktor antitestek és alkalmazásaik
WO2017091719A1 (en) * 2015-11-24 2017-06-01 Annexon, Inc. Anti-complement factor c1q fab fragments and uses thereof
KR20190005944A (ko) * 2016-05-09 2019-01-16 애넥슨, 인코포레이티드 척수성 근위축 치료용 조성물 및 방법
SG11201900123TA (en) * 2016-07-19 2019-02-27 Annexon Inc Compositions and methods for treating frontotemporal dementia
US20190248885A1 (en) * 2016-10-26 2019-08-15 The Board Of Trustees Of The Leland Stanford Junior University Neuronal and Oligodendrocyte Survival Modulation
JP6982226B2 (ja) * 2017-07-06 2021-12-17 日東紡績株式会社 抗ヒトＩｇＧ４モノクローナル抗体、およびその抗体を利用したヒトＩｇＧ４測定試薬
EP3710589A4 (en) * 2017-11-14 2021-11-10 Chugai Seiyaku Kabushiki Kaisha ANTI-C1S ANTIBODIES AND METHOD OF USING
BR112020018357A2 (pt) * 2018-04-13 2020-12-29 Chugai Seiyaku Kabushiki Kaisha Anticorpos de componente anticomplemento e métodos de uso
ES3015004T3 (en) * 2018-11-02 2025-04-28 Annexon Inc Compositions and methods for treating brain injury
KR102662915B1 (ko) * 2018-11-22 2024-05-03 쑤저우 카노바 바이오파마슈티컬 컴퍼니 리미티드 항-b7-h3 항체
CN119371526A (zh) 2018-12-13 2025-01-28 阿尔金克斯有限公司 针对人补体因子C2b的抗体及使用方法
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WO2023114763A1 (en) * 2021-12-13 2023-06-22 Annexon, Inc. Anti-complement factor c1q antibodies with single binding arms and uses thereof
WO2023126821A1 (en) * 2021-12-29 2023-07-06 Curateq Biologics Private Limited C1q binding assay
WO2023221833A1 (zh) * 2022-05-20 2023-11-23 浙江大学 阻断胸膜间皮细胞cd93的活性物质及应用
CN119371528B (zh) * 2024-10-30 2025-06-24 泰州市人民医院 一种C1q抗体及其应用、一种抑制补体经典途径活化的药剂及其应用

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