MXPA05011886A - Metodos y composiciones para la prevencion y tratamiento de septicemia. - Google Patents
Metodos y composiciones para la prevencion y tratamiento de septicemia.Info
- Publication number
- MXPA05011886A MXPA05011886A MXPA05011886A MXPA05011886A MXPA05011886A MX PA05011886 A MXPA05011886 A MX PA05011886A MX PA05011886 A MXPA05011886 A MX PA05011886A MX PA05011886 A MXPA05011886 A MX PA05011886A MX PA05011886 A MXPA05011886 A MX PA05011886A
- Authority
- MX
- Mexico
- Prior art keywords
- sepsis
- prevention
- compositions
- treatment
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un metodo para prevenir o tratar la septicemia administrando conjuntamente a un paciente una cantidad para prevenir o tratar la septicemia de uno o mas inhibidores del complemento y una cantidad para prevenir o tratar la septicemia de uno o mas inhibidores de la via CD14. Los inhibidores del complemento son de preferencia anticuerpos que se unen a proteinas del complemento como C5a y las inhiben y los inhibidores de la via CD14 son de preferencia anticuerpos que se unen a componentes de la via CD14 como CD14 y LPS y los inhiben.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47068103P | 2003-05-15 | 2003-05-15 | |
PCT/US2004/015135 WO2004103294A2 (en) | 2003-05-15 | 2004-05-14 | Methods and compositions for the prevention and treatment of sepsis |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05011886A true MXPA05011886A (es) | 2006-02-17 |
Family
ID=33476736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05011886A MXPA05011886A (es) | 2003-05-15 | 2004-05-14 | Metodos y composiciones para la prevencion y tratamiento de septicemia. |
Country Status (11)
Country | Link |
---|---|
US (1) | US8329169B2 (es) |
EP (2) | EP2266606B1 (es) |
JP (2) | JP4768620B2 (es) |
CN (2) | CN102258784A (es) |
AU (2) | AU2004241069B2 (es) |
CA (1) | CA2524534C (es) |
DK (1) | DK1628530T3 (es) |
ES (2) | ES2522525T3 (es) |
HK (1) | HK1152474A1 (es) |
MX (1) | MXPA05011886A (es) |
WO (1) | WO2004103294A2 (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8080245B2 (en) * | 2004-08-04 | 2011-12-20 | University Of Massachusetts | Anti-pathogen immunoadhesins |
WO2006063150A2 (en) | 2004-12-08 | 2006-06-15 | Immunomedics, Inc. | Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer |
WO2008154018A2 (en) * | 2007-06-11 | 2008-12-18 | The Trustees Of The University Of Pennsylvania | Properdin modulation of alternative pathway and uses thereof |
US20110190221A1 (en) * | 2008-03-28 | 2011-08-04 | Apellis Ag | Modulation and repletion/enhancement of the complement system for treatment of trauma |
WO2010135717A2 (en) | 2009-05-21 | 2010-11-25 | Potentia Pharmaceuticals, Inc. | Complement assays and uses thereof |
RU2012102021A (ru) | 2009-06-23 | 2013-07-27 | Алексион Фармасьютикалз, Инк. | Биспецифические антитела, которые связываются с белками комплемента |
EP2309001A1 (de) * | 2009-09-23 | 2011-04-13 | SIRS-Lab GmbH | Verfahren zur in vitro Erfassung und Unterscheidung von pathophysiologischen Zuständen |
US9358266B2 (en) * | 2010-02-25 | 2016-06-07 | The Trustees Of The University Of Pennsylvania | Treatment of sepsis using complement inhibitors |
EP2545075B1 (en) * | 2010-03-10 | 2020-07-01 | NovelMed Therapeutics, Inc. | Humanized and chimeric anti-properdin antibodies |
CA2797856C (en) | 2010-04-30 | 2018-09-18 | Alexion Pharmaceuticals, Inc. | Anti-c5a antibodies and methods for using the antibodies |
US9120838B2 (en) | 2011-04-18 | 2015-09-01 | Curators Of The University Of Missouri | Saccharide conjugates |
EP2708233B1 (en) | 2011-05-13 | 2018-06-27 | The University of Tokyo | Ctrp6 which can be used as therapeutic and prophylactic agent for autoimmune diseases |
MX352621B (es) * | 2011-05-19 | 2017-12-01 | Mochida Pharm Co Ltd | Diagnostico de la enfermedad infecciosa del tracto respiratorio usando especimenes de sangre. |
ES2701075T3 (es) | 2011-07-01 | 2019-02-20 | Univ Pennsylvania | Anticuerpos antiproperdina y usos de estos |
CN102363781A (zh) * | 2011-10-19 | 2012-02-29 | 海南大学 | 一种有效抑制小鼠mCD14基因表达的小干扰核糖核酸分子 |
CN102533758B (zh) * | 2011-10-19 | 2014-04-02 | 海南大学 | 一种抑制水牛膜分化抗原14 基因表达的小核糖核酸分子 |
SG11201403416TA (en) | 2011-12-21 | 2014-07-30 | Novartis Ag | Compositions and methods for antibodies targeting factor p |
CA2889170C (en) | 2012-10-25 | 2021-09-07 | True North Therapeutics, Inc. | Anti-complement c1s antibodies and uses thereof |
CN116063483A (zh) | 2012-11-02 | 2023-05-05 | 美国比奥维拉迪维股份有限公司 | 抗补体C1s抗体和其用途 |
EP2997045A4 (en) * | 2013-05-15 | 2016-11-23 | Annexon Inc | ANTI-FACTOR C1S ANTIBODIES OF THE COMPLEMENT AND USES THEREOF |
EP4252769A3 (en) | 2013-07-09 | 2023-11-29 | Annexon, Inc. | Anti-complement factor c1q antibodies and uses thereof |
EP3011345B1 (en) * | 2013-08-07 | 2017-10-04 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (ahus) biomarker proteins |
WO2015054569A1 (en) * | 2013-10-10 | 2015-04-16 | Viropharma Holdings Limited | Methods of inhibiting the alternative pathway of complement immune system activation and compositions used therein |
US20160289270A1 (en) * | 2013-11-18 | 2016-10-06 | Westfaelische Wilhelms-Universitaet Muenster | Methods, Peptides and Antibodies for Preventing, Treating and Diagnosing an Inflammatory Condition |
WO2015140591A1 (en) * | 2014-03-21 | 2015-09-24 | Nordlandssykehuset Hf | Anti-cd14 antibodies and uses thereof |
EP3973994A1 (en) | 2014-06-12 | 2022-03-30 | RA Pharmaceuticals, Inc. | Modulation of complement activity |
SG11201703667SA (en) | 2014-11-05 | 2017-06-29 | Annexon Inc | Humanized anti-complement factor c1q antibodies and uses thereof |
US20160168237A1 (en) * | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | Method for treating a complement mediated disorder caused by an infectious agent in a patient |
ES2900998T3 (es) | 2015-01-28 | 2022-03-21 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento |
ES2938359T3 (es) | 2015-04-06 | 2023-04-10 | Bioverativ Usa Inc | Anticuerpos humanizados anti-C1s y métodos de uso de los mismos |
WO2017075189A1 (en) | 2015-10-27 | 2017-05-04 | University Of Massachusetts | Factor h-fc immunotherapy |
CN108779171B (zh) | 2015-11-24 | 2022-07-05 | 安尼艾克松股份有限公司 | 抗补体因子c1q的fab片段及其应用 |
CN108697759B (zh) | 2015-12-16 | 2022-08-02 | Ra制药公司 | 补体活性的调节剂 |
WO2017134043A1 (en) * | 2016-02-01 | 2017-08-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for neutralising the cytotoxic activity of extracellular histone proteins in subjects suffering from sepsis |
BR112019011053A2 (pt) | 2016-12-07 | 2019-10-15 | Ra Pharmaceuticals Inc | moduladores da atividade do complemento |
TW201938184A (zh) | 2017-12-04 | 2019-10-01 | 美商Ra製藥公司 | 補體活性之調節劑 |
GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
WO2020011869A2 (en) | 2018-07-11 | 2020-01-16 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting tlr2 |
US20220160820A1 (en) | 2019-03-08 | 2022-05-26 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
JP2022527508A (ja) | 2019-03-29 | 2022-06-02 | ラ ファーマシューティカルズ インコーポレイテッド | 補体モジュレータ及び関連方法 |
BR112021017820A2 (pt) | 2019-04-24 | 2022-02-08 | Ra Pharmaceuticals Inc | Composições e métodos para modulação da atividade de complemento |
Family Cites Families (43)
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
EP0245993B1 (en) | 1986-04-28 | 1993-05-26 | Cetus Oncology Corporation | Monoclonal antibodies against c5a and des-arg74-c5a, their production and use |
US5093117A (en) | 1989-01-24 | 1992-03-03 | Baxter International Inc. | Compositions and method for the treatment or prophylaxis of sepsis or septic shock |
DK0485430T3 (da) | 1989-08-01 | 1999-06-14 | Scripps Research Inst | Fremgangsmåder og sammensætninger til bedring af symptomer på sepsis |
US6315999B1 (en) * | 1989-08-10 | 2001-11-13 | Solvay, S.A. | Pharmaceutical product for the treatment of sepsis |
DE4029227A1 (de) | 1990-09-14 | 1992-03-19 | Imtox Gmbh | Arzneimittel enthaltend cd14 |
AU2694592A (en) | 1991-09-30 | 1993-05-03 | Walser, Mackenzie | Methods for treatment of free-radical-mediated tissue injury |
CA2133758A1 (en) | 1992-04-06 | 1993-10-14 | Sanna M. Goyert | A novel therapy for treating sepsis using a soluble form of recombinant cd14 myelomonocytic antigen |
US6063764A (en) | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
US5330754A (en) * | 1992-06-29 | 1994-07-19 | Archana Kapoor | Membrane-associated immunogens of mycobacteria |
ATE223230T1 (de) | 1993-02-12 | 2002-09-15 | Avant Immunotherapeutics Inc | Pulmonäre verabreichung des löslichen komplement- receptors typ 1 scr1 |
AU695124B2 (en) | 1993-05-28 | 1998-08-06 | Scripps Research Institute, The | Methods and compositions for inhibiting CD14 mediated cell activation |
CN1216992C (zh) * | 1994-07-05 | 2005-08-31 | 史廷诺研究集团有限公司 | 免疫调节剂 |
EP0792162B1 (en) | 1994-09-16 | 2005-11-09 | The Scripps Research Institute | Use of antibodies to block the effects of gram-positive bacteria and mycobacteria |
CN1171117A (zh) * | 1994-12-23 | 1998-01-21 | 实验室奥姆公司 | Mhc-ⅱ结合和/或mhc-ⅱ模拟分子用于预防和/或治疗炎性疾病的用途 |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US6042821A (en) | 1995-11-21 | 2000-03-28 | Smithkline Beecham Corporation | Method of treating sepsis with chemokines |
US6290948B1 (en) | 1996-05-14 | 2001-09-18 | Smithkline Beecham Corporation | Method of treating sepsis and ARDS using chamohine beta-10 |
CN1226171A (zh) * | 1996-05-22 | 1999-08-18 | 艾伯塔大学 | 2-型趋化因子结合蛋白及其使用方法 |
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US6172220B1 (en) | 1997-01-21 | 2001-01-09 | Board Of Regents Of University Of Nebraska | Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis |
WO1998039438A1 (fr) | 1997-03-07 | 1998-09-11 | Mochida Pharmaceutical Co., Ltd. | Composes antisens diriges contre cd14 |
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MXPA01003073A (es) * | 1998-09-24 | 2002-04-24 | Univ Minnesota | Polipeptido que degrada la proteina c3 complementaria humana a partir de streptococcus pneumoniae. |
CN1324244A (zh) * | 1998-10-22 | 2001-11-28 | 伊莱利利公司 | 治疗脓毒症的方法 |
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DE19913707A1 (de) | 1999-03-26 | 2000-10-05 | Privates Inst Bioserv Gmbh | Immunadsorber zur Sepsistherapie |
CZ20013577A3 (cs) * | 1999-04-09 | 2002-07-17 | Basf Aktiengesellschaft | Inhibitory komplementních proteáz s nízkou molekulovou hmotností |
NZ515374A (en) * | 1999-05-18 | 2004-09-24 | Teijin Ltd | Remedies or prophylactics for diseases in association with chemokines |
US6673346B1 (en) * | 1999-08-31 | 2004-01-06 | The Regents Of The University Of Michigan | Compositions and methods for the treatment of sepsis |
JP2003522159A (ja) * | 2000-02-08 | 2003-07-22 | ザ ユニバーシティ オブ ヴァージニア パテント ファウンデーション | 抗C3b(i)抗体を用いる感染の予防および治療のための方法 |
US20020006915A1 (en) | 2000-02-15 | 2002-01-17 | Mack Strong Vivian E. | Use of COX-2 inhibitors to treat sepsis, complications thereof, and EP receptor modulation |
US20040092712A1 (en) | 2000-03-31 | 2004-05-13 | Shoji Furusako | Tlr/cd14 binding inhibitor |
WO2001072993A1 (fr) | 2000-03-31 | 2001-10-04 | Mochida Pharmaceutical Co., Ltd. | Inhibiteur de liaison entre le recepteur de type toll et cd14 |
ATE404553T1 (de) | 2000-09-29 | 2008-08-15 | Neurogen Corp | Hochaffine kleinmolekülige c5a-rezeptor- modulatoren |
CA2429467A1 (en) | 2000-11-22 | 2002-05-30 | Mochida Pharmaceutical Co., Ltd. | Anti-cd14 monoclonal antibody having effect of inhibiting cd14/tlr binding |
NZ526720A (en) | 2000-12-28 | 2007-11-30 | Altus Pharmaceuticals Inc | Crystallisation of whole antibodies or fragments thereof, on a large scale and a process allowing an alternative route for delivery of therapeutic antibodies |
WO2002074789A2 (en) * | 2001-03-20 | 2002-09-26 | Baylor College Of Medicine | Use of monoclonal antibodies and functional assays for prediction of risk of opportunistic infection |
SI1425028T1 (sl) | 2001-05-16 | 2010-02-26 | Yeda Res & Dev | Uporaba inhibitorjev za il-18 za zdravljenje ali prepreäśevanje sepse |
US7432356B2 (en) | 2001-08-17 | 2008-10-07 | Genentech, Inc. | Complement pathway inhibitors binding to C5 and C5a without preventing formation of C5b |
CN101897969B (zh) * | 2003-02-21 | 2014-04-02 | 健泰科生物技术公司 | 补体抑制剂在制备用于预防或抑制组织损伤的药物中的用途 |
-
2004
- 2004-05-14 AU AU2004241069A patent/AU2004241069B2/en not_active Ceased
- 2004-05-14 WO PCT/US2004/015135 patent/WO2004103294A2/en active Application Filing
- 2004-05-14 CN CN201110169068A patent/CN102258784A/zh active Pending
- 2004-05-14 ES ES10179747.0T patent/ES2522525T3/es not_active Expired - Lifetime
- 2004-05-14 CN CN2004800126841A patent/CN1787741B/zh not_active Expired - Fee Related
- 2004-05-14 DK DK04752211.5T patent/DK1628530T3/da active
- 2004-05-14 EP EP10179747.0A patent/EP2266606B1/en not_active Expired - Lifetime
- 2004-05-14 JP JP2006533066A patent/JP4768620B2/ja not_active Expired - Fee Related
- 2004-05-14 US US10/556,998 patent/US8329169B2/en not_active Expired - Fee Related
- 2004-05-14 ES ES04752211T patent/ES2387275T3/es not_active Expired - Lifetime
- 2004-05-14 MX MXPA05011886A patent/MXPA05011886A/es active IP Right Grant
- 2004-05-14 EP EP04752211A patent/EP1628530B8/en not_active Expired - Fee Related
- 2004-05-14 CA CA2524534A patent/CA2524534C/en not_active Expired - Fee Related
-
2010
- 2010-12-06 AU AU2010249190A patent/AU2010249190B2/en not_active Ceased
-
2011
- 2011-01-27 JP JP2011014797A patent/JP2011105747A/ja active Pending
- 2011-06-23 HK HK11106525.8A patent/HK1152474A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US8329169B2 (en) | 2012-12-11 |
CN1787741A (zh) | 2006-06-14 |
EP1628530B1 (en) | 2012-06-06 |
CA2524534A1 (en) | 2004-12-02 |
CN102258784A (zh) | 2011-11-30 |
US20070274989A1 (en) | 2007-11-29 |
CA2524534C (en) | 2012-12-11 |
WO2004103294A2 (en) | 2004-12-02 |
WO2004103294A3 (en) | 2005-05-26 |
ES2522525T3 (es) | 2014-11-14 |
ES2387275T3 (es) | 2012-09-19 |
AU2004241069B2 (en) | 2010-09-09 |
JP2006528981A (ja) | 2006-12-28 |
EP2266606B1 (en) | 2014-09-10 |
EP1628530B8 (en) | 2012-08-01 |
AU2004241069A1 (en) | 2004-12-02 |
EP2266606A1 (en) | 2010-12-29 |
EP1628530A4 (en) | 2007-08-29 |
JP2011105747A (ja) | 2011-06-02 |
HK1152474A1 (en) | 2012-03-02 |
EP1628530A2 (en) | 2006-03-01 |
DK1628530T3 (da) | 2012-07-23 |
AU2010249190B2 (en) | 2013-02-28 |
CN1787741B (zh) | 2011-08-17 |
AU2010249190A1 (en) | 2011-01-06 |
JP4768620B2 (ja) | 2011-09-07 |
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GB | Transfer or rights |