CN107177001A - 一种防治猪流行性腹泻病的卵黄抗体及其制备方法 - Google Patents
一种防治猪流行性腹泻病的卵黄抗体及其制备方法 Download PDFInfo
- Publication number
- CN107177001A CN107177001A CN201610132133.3A CN201610132133A CN107177001A CN 107177001 A CN107177001 A CN 107177001A CN 201610132133 A CN201610132133 A CN 201610132133A CN 107177001 A CN107177001 A CN 107177001A
- Authority
- CN
- China
- Prior art keywords
- yolk antibody
- yolk
- epidemic diarrhea
- porcine epidemic
- exempt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002969 egg yolk Anatomy 0.000 title claims abstract description 58
- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 241001135549 Porcine epidemic diarrhea virus Species 0.000 claims abstract description 43
- 239000007788 liquid Substances 0.000 claims abstract description 24
- 229940031551 inactivated vaccine Drugs 0.000 claims abstract description 9
- 238000012360 testing method Methods 0.000 claims abstract description 7
- 238000003306 harvesting Methods 0.000 claims abstract description 5
- 230000003053 immunization Effects 0.000 claims abstract description 5
- 238000002649 immunization Methods 0.000 claims abstract description 4
- 241000700605 Viruses Species 0.000 claims description 18
- 230000002779 inactivation Effects 0.000 claims description 17
- 239000002671 adjuvant Substances 0.000 claims description 13
- 239000006228 supernatant Substances 0.000 claims description 11
- 229960005486 vaccine Drugs 0.000 claims description 11
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 9
- 238000000746 purification Methods 0.000 claims description 9
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 8
- 229960000380 propiolactone Drugs 0.000 claims description 7
- 102000002322 Egg Proteins Human genes 0.000 claims description 6
- 108010000912 Egg Proteins Proteins 0.000 claims description 6
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 claims description 6
- 238000005119 centrifugation Methods 0.000 claims description 6
- 230000036039 immunity Effects 0.000 claims description 6
- 210000003501 vero cell Anatomy 0.000 claims description 6
- 235000013345 egg yolk Nutrition 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 210000002976 pectoralis muscle Anatomy 0.000 claims description 5
- 230000003612 virological effect Effects 0.000 claims description 5
- 229920001817 Agar Polymers 0.000 claims description 4
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 4
- 235000013601 eggs Nutrition 0.000 claims description 4
- 238000012817 gel-diffusion technique Methods 0.000 claims description 4
- 238000011081 inoculation Methods 0.000 claims description 4
- 238000004321 preservation Methods 0.000 claims description 4
- 238000001179 sorption measurement Methods 0.000 claims description 4
- 108010019160 Pancreatin Proteins 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 239000012930 cell culture fluid Substances 0.000 claims description 3
- 230000002163 immunogen Effects 0.000 claims description 3
- 229940055695 pancreatin Drugs 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 230000000937 inactivator Effects 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 abstract description 6
- 238000011282 treatment Methods 0.000 abstract description 6
- 238000006386 neutralization reaction Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 244000005700 microbiome Species 0.000 description 6
- 239000002574 poison Substances 0.000 description 6
- 231100000614 poison Toxicity 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 210000003022 colostrum Anatomy 0.000 description 3
- 235000021277 colostrum Nutrition 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000204031 Mycoplasma Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 230000008774 maternal effect Effects 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101150010882 S gene Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 238000011091 antibody purification Methods 0.000 description 1
- 230000007910 cell fusion Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000037111 immune power Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000013081 phylogenetic analysis Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/02—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from eggs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
组别 | 1日 | 2日 | 3日 | 4日 | 5日 | 存活率 |
1组治疗组 | 10/10 | 10/10 | 6/10 | 2/10 | 0/10 | 100% |
2组非治疗组 | 10/10 | 10/10 | 8/8 | 5/5 | 4/4 | 40% |
3组空白对照 | 10/10 | 10/10 | 10/10 | 10/10 | 10/10 | 100% |
组别 | 14日内发生腹泻仔猪数量 | 发病率 |
1组 | 4 | 10% |
2组 | 12 | 30% |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610132133.3A CN107177001B (zh) | 2016-03-09 | 2016-03-09 | 一种防治猪流行性腹泻病的卵黄抗体及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610132133.3A CN107177001B (zh) | 2016-03-09 | 2016-03-09 | 一种防治猪流行性腹泻病的卵黄抗体及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107177001A true CN107177001A (zh) | 2017-09-19 |
CN107177001B CN107177001B (zh) | 2021-01-01 |
Family
ID=59829581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610132133.3A Active CN107177001B (zh) | 2016-03-09 | 2016-03-09 | 一种防治猪流行性腹泻病的卵黄抗体及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107177001B (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109111518A (zh) * | 2018-08-31 | 2019-01-01 | 广西壮族自治区兽医研究所 | 防治猫瘟热的特异性卵黄抗体及其制备方法 |
CN109234244A (zh) * | 2018-09-29 | 2019-01-18 | 河南农业大学 | 猪流行性腹泻病毒变异毒株及其在制备高免卵黄抗体中的应用 |
CN109336971A (zh) * | 2018-11-06 | 2019-02-15 | 哈药集团生物疫苗有限公司 | 鹅星状病毒卵黄抗体的制备方法及其产品 |
CN110007077A (zh) * | 2019-04-03 | 2019-07-12 | 安徽省农业科学院畜牧兽医研究所 | 一种猪流行性腹泻病毒琼扩抗原及其用于抗体检测的检测方法 |
CN111110778A (zh) * | 2020-02-03 | 2020-05-08 | 中山大学 | 芦荟提取物在制备防治猪流行性腹泻的药物中的应用 |
CN111217906A (zh) * | 2018-11-27 | 2020-06-02 | 郑洪杰 | 猪消化系统疾病的预防或治疗用卵黄抗体的制造方法以及基于此而制造的卵黄抗体及其用途 |
CN113845588A (zh) * | 2021-05-26 | 2021-12-28 | 西南民族大学 | 一种抗猪轮状病毒的卵黄抗体的制备方法及其用途 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130052329A (ko) * | 2011-11-11 | 2013-05-22 | 주식회사 단바이오텍 | 경구투여용 철분제 |
CN104491861A (zh) * | 2014-12-14 | 2015-04-08 | 郑州后羿制药有限公司 | 一种猪瘟病卵黄抗体口服液及其制备方法 |
CN104667269A (zh) * | 2015-02-02 | 2015-06-03 | 广东海大畜牧兽医研究院有限公司 | 一种猪流行性腹泻病毒鼻腔免疫疫苗及其制备方法 |
-
2016
- 2016-03-09 CN CN201610132133.3A patent/CN107177001B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130052329A (ko) * | 2011-11-11 | 2013-05-22 | 주식회사 단바이오텍 | 경구투여용 철분제 |
CN104491861A (zh) * | 2014-12-14 | 2015-04-08 | 郑州后羿制药有限公司 | 一种猪瘟病卵黄抗体口服液及其制备方法 |
CN104667269A (zh) * | 2015-02-02 | 2015-06-03 | 广东海大畜牧兽医研究院有限公司 | 一种猪流行性腹泻病毒鼻腔免疫疫苗及其制备方法 |
Non-Patent Citations (6)
Title |
---|
CHANG-HEE KWEON,ET AL.: "Immunoprophylactic effect of chicken egg yolk immunoglobulin (Ig Y) against porcine epidemic diarrhea virus (PEDV) in piglets", 《JOURNAL OF VETERINARY MEDICAL SCIENCE》 * |
宋维平等: "抗猪流行性腹泻病毒卵黄抗体", 《华北农学报》 * |
李冰等: "抗猪流行性腹泻病毒卵黄抗体的制备及应用", 《中国畜牧兽医》 * |
王金洛等: "抗猪流行性腹泻病毒卵黄抗体(PEDV-IgY) 及其特性研究", 《中国畜牧兽医学会2003年学术年会论文集》 * |
胡青松等: "猪流行性腹泻病毒3种抗原卵黄抗体的制备", 《西北农林科技大学学报(自然科学版)》 * |
马福宝: "《社区预防接种实用手册》", 31 January 2016, 苏州大学出版社 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109111518A (zh) * | 2018-08-31 | 2019-01-01 | 广西壮族自治区兽医研究所 | 防治猫瘟热的特异性卵黄抗体及其制备方法 |
CN109111518B (zh) * | 2018-08-31 | 2022-03-15 | 广西壮族自治区兽医研究所 | 防治猫瘟热的特异性卵黄抗体及其制备方法 |
CN109234244A (zh) * | 2018-09-29 | 2019-01-18 | 河南农业大学 | 猪流行性腹泻病毒变异毒株及其在制备高免卵黄抗体中的应用 |
CN109336971A (zh) * | 2018-11-06 | 2019-02-15 | 哈药集团生物疫苗有限公司 | 鹅星状病毒卵黄抗体的制备方法及其产品 |
CN111217906A (zh) * | 2018-11-27 | 2020-06-02 | 郑洪杰 | 猪消化系统疾病的预防或治疗用卵黄抗体的制造方法以及基于此而制造的卵黄抗体及其用途 |
CN110007077A (zh) * | 2019-04-03 | 2019-07-12 | 安徽省农业科学院畜牧兽医研究所 | 一种猪流行性腹泻病毒琼扩抗原及其用于抗体检测的检测方法 |
CN110007077B (zh) * | 2019-04-03 | 2022-02-22 | 安徽省农业科学院畜牧兽医研究所 | 一种猪流行性腹泻病毒琼扩抗原及其用于抗体检测的检测方法 |
CN111110778A (zh) * | 2020-02-03 | 2020-05-08 | 中山大学 | 芦荟提取物在制备防治猪流行性腹泻的药物中的应用 |
CN111110778B (zh) * | 2020-02-03 | 2021-10-01 | 中山大学 | 芦荟提取物在制备防治猪流行性腹泻的药物中的应用 |
CN113845588A (zh) * | 2021-05-26 | 2021-12-28 | 西南民族大学 | 一种抗猪轮状病毒的卵黄抗体的制备方法及其用途 |
CN113845588B (zh) * | 2021-05-26 | 2023-06-09 | 西南民族大学 | 一种抗猪轮状病毒的卵黄抗体的制备方法及其用途 |
Also Published As
Publication number | Publication date |
---|---|
CN107177001B (zh) | 2021-01-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107177001A (zh) | 一种防治猪流行性腹泻病的卵黄抗体及其制备方法 | |
CN103263666B (zh) | 猪圆环病毒2型、猪支原体肺炎二联灭活疫苗及其制备方法 | |
CN106497890B (zh) | 一种猪伪狂犬病病毒变异株xf-1株及制备方法和应用 | |
CN105327344B (zh) | 含有猪圆环病毒2型抗原与副猪嗜血杆菌抗原的疫苗组合物及其制备方法与应用 | |
CN101845095A (zh) | 一种猪传染性胃肠炎、流行性腹泻病毒二联蛋黄抗体的制备方法 | |
CN104498441B (zh) | 鸭甲肝病毒iii型弱毒株及由其制备的活疫苗和应用 | |
CN103585626B (zh) | 一种鸡新城疫、法氏囊病二联复合灭活疫苗的制备方法 | |
CN106591244B (zh) | 一种猪流行性腹泻病毒、灭活疫苗及其制备方法 | |
CN108486067A (zh) | 猪流行性腹泻病毒变异株及其制备的灭活疫苗和应用 | |
CN106554944A (zh) | 猪流行性腹泻病毒弱毒株及其制备的疫苗组合物和应用 | |
CN104788561A (zh) | 抗猪传染性胃肠炎病毒与猪流行性腹泻病毒卵黄抗体及其制备方法 | |
CN105949307B (zh) | 一种用于防治番鸭源小鹅瘟的卵黄抗体 | |
CN107988170A (zh) | 猪轮状病毒毒株及其制备的灭活疫苗和应用 | |
CN110872578A (zh) | 一株变异株传染性法氏囊病毒、亚单位疫苗及其制备方法和应用 | |
CN104043117B (zh) | 一种疫苗组合物及其制备方法和应用 | |
CN103833848A (zh) | 一种用于预防治疗番鸭细小病毒病的卵黄抗体 | |
CN104258389B (zh) | 一种疫苗组合物及其制备方法和应用 | |
CN103554254A (zh) | 一种抗人a组轮状病毒的鸡卵黄抗体及其制备方法和应用 | |
CN106854647B (zh) | 鸭病毒性肝炎二价蛋黄抗体及其制备方法和应用 | |
CN108465107B (zh) | 一种鸭2型腺病毒和番鸭细小病毒病二联灭活疫苗 | |
CN107880120B (zh) | 一种猪传染性胃肠炎病毒卵黄抗体及其制备方法 | |
CN111808826B (zh) | 猪A型塞内卡病毒SVA/CH-Fuj株及其应用 | |
CN104087559B (zh) | 一种传染性法氏囊病毒、灭活疫苗及其制备方法 | |
CN103705918B (zh) | 抗猪流行性腹泻病毒高免血清及其制备方法 | |
CN106190991B (zh) | 一种禽脑脊髓炎病毒、灭活疫苗及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20170919 Assignee: CHINA TECHNOLOGY EXCHANGE Co.,Ltd. Assignor: BEIJING VICA BIOTECHNOLOGY CO.,LTD. Contract record no.: X2021980013179 Denomination of invention: The invention relates to an egg yolk antibody for preventing and treating porcine epidemic diarrhea and a preparation method thereof Granted publication date: 20210101 License type: Exclusive License Record date: 20211124 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: The invention relates to an egg yolk antibody for preventing and treating porcine epidemic diarrhea and a preparation method thereof Effective date of registration: 20211125 Granted publication date: 20210101 Pledgee: CHINA TECHNOLOGY EXCHANGE Co.,Ltd. Pledgor: BEIJING VICA BIOTECHNOLOGY CO.,LTD. Registration number: Y2021110000070 |