CN1071336A - Making, the application process of broad spectrum activity control fish, shrimp, shellfish, Eriocheir sinensis disease outbreak medicine - Google Patents

Abstract

The invention provides making, the application process of a kind of wide spectrum control fish, shrimp, shellfish, Eriocheir sinensis disease outbreak medicine.The core of this medicine is 7 kinds of Chinese herbal medicine.This medicine can be made pharmaceutical chemistry, also can directly splash among water body, carries out bionomic control.The present invention has captured the difficult problem of domestic and international control fish, shrimp, shellfish, Eriocheir sinensis disease outbreak, and medicine material is wide, making and easy to use, and the curative effect height, safe and reliable, have no side effect, be easy in production reality, widely popularize.

Description

Making, the application process of broad spectrum activity control fish, shrimp, shellfish, Eriocheir sinensis disease outbreak medicine

The present invention relates to light, the sea water of a kind of control, comprise the making application process of fish in the brackish culture industry, shrimp, shellfish, Eriocheir sinensis fulminant disease medicament.

The control of fish, shrimp, shellfish, Eriocheir sinensis fulminant disease is the difficult problem of aquatic animal illness, and there can be no exception whatever both at home and abroad.The fulminant infectious disease is caused by virus mostly, the west to the virus research history of aquatic animal early, that describe Fish herpesvirus (Herpes virus) at first is Schubert(1966), but the control of virosis still there is not breakthrough until the eighties, its medicine is generally used (Kurstak such as chlorine compound, formalin, strong alkali compound, E., 1982.Control of virus diseases.Marcel Dekker, INC.printed in USA 197-217).In Europe to salmon, the viral disease of Squaliobarbus ourriculus class, especially infectiousness hemopoietic organ necrosis (IHN), so far mainly take the method prevention of immunity, and there are not therapy measure and medicine (Gilmore, R.D.Jr, et al., 1988.Expression in escherichia coli of an epitope of the glycoprotein of IHNV protects against virus challenge, Bietechnology.6,295-300.) fishes infectious pancreas necrosis (IPN) has only the method (Havarstein of immunoprophylaxis too, L.S.et al., 1990.Specific immunolobulins in serum from atlantic salmon salar L., immunized with Vibrio Salmonocida and infectious pancreatic necrosis virus.J.of Fish Diseases.13(2): 101-111.).But preventing the invasion and attack of multiple diseases, is quite difficult, simultaneously also uneconomical for aquatic animal.Fulminant disease " hemorrhagic disease " as the Ctenopharyngodon idellus (Ctenopharyngodonidellus) of China is because arc reovirus virus (Roevirus) (Wuhan Virology Institute,Chinan academy of Sciences etc., 1984. the research of the fine structure of hemorrhagic disease of grass carp, fresh water fishery, 2: 21-23) cause enterorrhagia, cause hemorrhage of muscle (Mao Shujian etc., 1989 by picornavirus.The cause of disease research of hemorrhagic disease of grass carp.Aquatic product journal, 13(1): 1-4).If bacterial infection is combined, treatment Fish disease outbreak is exactly a very arduous difficult problem again.

The fulminant disease of shellfish also is like this, the sick expert Elston.R.A professor of the famous shellfish of the sick research of U.S.'s sea water control centre, speaking of Europe Atlantic oyster (Crassostredgigas) virosis (OVVD) in his nearly version works says when popular and does not effectively tackle this sick way (Elston, R.A., 1990.Mollusc disease, printed in USA, 1-47.) Kurstak.E.(1982) think sodium hypochlorite, formalin, highly basic has therapeutic efficiency to virosis, but look forward to total effect is dim (Kurstak, E., 1982.Control of virus diseases.Marcel Dekker, INC.printed in USA, 217-239.) also think the sulfate of ferrum and aluminum, ozone, the dyestuff of activated carbon and photosensitization has inhibitory action (Kurstak to virus, E.et al., 1982.viruses and environment.Academic Press, printed in USA, 155-181).

Disease outbreak control as for shrimp and Eriocheir sinensis does not have effect method yet, even basic (Bian Baizhong etc., 1987 do not studied.Shrimps disease and control, Maritime Press, 16-20 page or leaf.Zhao is firm etc., 1988.Artificial propagation of crab and aquaculture, Anhui science and technology publishing house.Sparks，A.K.，Morado，J.F.，1987.A herpes-like virus disease in the blue king crab Paralithpdes Platypus.Aquaculture abstracts.4（2）：121-128.）

The common feature of fish, shrimp, shellfish, Eriocheir sinensis fulminant disease is to break with tremendous force, and propagates soon, and the mortality rate height brings tremendous loss often for the Aquatic product aquaculture, does not also have the effectively preventing method in the world wide.Particularly be used to throw something and feed and the research of the medicine of splashing aspect do not have major progress.

The objective of the invention is to seek a kind of economy and spend less, render a service height, easy to use and reliable, can diseases prevention can cure the disease again, not only can throw something and feed but also can splash, can in production reality, widely popularize, capture the medicine of control fish, shrimp, shellfish, Eriocheir sinensis fulminant disease difficulty.

This medicine is a kind of mixture that contains multiple components, its core and theory achievement are the methods that adopts Chinese herbal medicine and other medicine to combine, Chinese medicine and Chinese materia medica are organically combined, prepare by Chinese medicine " calentura is cold to be controlled, and cold febrile disease is controlled " and the dialectical principle of controlling of executing.Its Main Ingredients and Appearance and content are as follows:

(1) Chinese medicine Radix Glycyrrhizae, Folium Perillae, Radix Isatidis, Folium Isatidis, Indigo Naturalis, Radix Ophiopogonis, Cortex Cinnamomi seven flavors, every flavor Chinese herbal medicine consumption equalization, a few flavor Chinese medicine total amounts account for the 0.1-2.0% of patent medicine weight.In preparation, said herbal medicine allows to lack 1-3 flavor, but the dosage under lacking should be supplied by remaining Chinese herbal medicine, and total amount is not reduced.Cortex Cinnamomi can not lack.

(2) analysis for soybean powder after the fermentation and the Semen Maydis powder residue 85-91% that accounts for the medicine gross weight.

(3) Margarita layer powder accounts for the 3-6% of medicine gross weight.

(4) inorganic base of sodium, magnesium, potassium accounts for the 2-4.5% of medicine gross weight.

(5) sulfate of ferrum, copper, zinc accounts for the 0.5-1% of medicine gross weight.

(6) sodium, magnesium, potassium, cobaltic chloride account for the 1-5% of medicine gross weight.

(7) hemoporphyrin trace.

Chinese herbal medicine can dry or be no more than 70 ℃ oven for drying through sunlight, pulverizes mix homogeneously then, and its granularity is 40-300 μ.The fermentation residue that in the process of pulverizing, adds inorganic base, sulfate, chloride, hemoporphyrin, Semen Glycines and Semen Maydis powder.Add Margarita layer powder after pulverizing is finished again, make the full and uniform mixing of various components promptly make powdery patent medicine.

This medicine can directly be splashed in water, also medicine can be admixed in the bait and be thrown something and fed.When adding in the feedstuff, the weight ratio of medicine and feedstuff is 5: 95.The two is mixed and made into pharmaceutical chemistry, and the pharmaceutical chemistry consumption is 10-20 kg/ha sky.Treatment and prevention equivalent, continuous 5 days is a course of treatment, every month 2 courses of treatment of morbidity season.

If directly medicine is splashed in water, should earlier medicine be mixed with quicklime, medicine and quicklime weight ratio are 10: 90, quicklime is deliquescence slightly, is 1.0 centimetres sieve with the aperture, pulverizes then, granularity is 3-350 μ, crush the back and fully mix, in container, dilute earlier, splash in the water surface equably again with water dissolution by institute's expense with medicine.Dosage is: treatment 10-20 kg/ha sky (in 2 meters of the depth of waters, this dose comprises Calx weight, down together), prevention 5-10 kg/ha sky.Splash every day once, the next day medication, continuous 3 times is a course of treatment.Every month 2 courses of treatment of morbidity season.

This medicine has unique treatment and preventive effect to the disease outbreak of the disease outbreak of main fish such as grass, silver carp, flathead, Cyprinus carpio, crucian carp and shrimp, shellfish, Eriocheir sinensis.After morbidity waters dispenser, generally just can reduce death at second day, just can recover normal in 3-7 days.This medicine does not have any pollution to water body, and is without any side effects to Fish, is to treat one of best medicine of the disease outbreak that is caused by virus at present in the world.Main composition is a Chinese medicine in this medicine, and China is the native place of Chinese medicine, have inexhaustible, with it natural resources of Chinese medicinal materials without cease.This medical instrument has inexpensive, and is easy to make, curative effect height, advantage such as safe and reliable.

1: one pearl farm of embodiment, 3 hectares of the pearl culturing clam waters surface are supported 4.5 ten thousand of freshwater mussels, mix by 10: 90 with quicklime with medicine and splash, and consumption is 10 kg/ha skies, medication every other day, three times one courses of treatment, every month 2 courses of treatment.The freshwater mussel survival rate reaches 97.3% then, and with field 1.6 ten thousand of the medication raise clams pool freshwater mussels whole death rays in three months not then.

The prescription of this medicine is: account for altogether Radix Glycyrrhizae, Folium Perillae, Folium Isatidis, Indigo Naturalis, Cortex Cinnamomi, Radix Isatidis, Radix Ophiopogonis total medicine heavy 0.84%, every flavor equivalent.Ferrous sulfate accounts for 0.6%, and sodium carbonate accounts for 3%, and potassium chloride accounts for 1%, and Margarita layer powder accounts for 3.4%, and the Semen Glycines after the fermentation, Semen Maydis powder residue account for 91.0%, and blood porphin woods accounts for 0.61%.

Totally 3 of 2: one fish farms of embodiment, 0.2 hectare fishpond, 1.6 meters of the depth of waters are put summer flower Ctenopharyngodon idellus kind 7.2 ten thousand tails then, in 5-10 month, use bait feeding, and the weight ratio of medicine and bait is 5: 95.Dosage is 15 kg/ha skies, and continuous 7 days is a course of treatment, obtains big specification Ctenopharyngodon idellus kind 6.5 ten thousand tails the end of the year every month 2 course of treatment, and survival rate reaches 90%, and with the field not medication fishpond survival rate have only 38%.Its pharmaceutical formulation and embodiment 1 are together.

Claims (6)

1, a kind of control fish, shrimp, shellfish, Eriocheir sinensis disease outbreak medicine production method is characterized in that:

(1) component is: Radix Glycyrrhizae, Folium Perillae, Radix Isatidis, Folium Isatidis, Indigo Naturalis, Radix Ophiopogonis, 7 kinds of dosages of drug of Cortex Cinnamomi are identical, account for the 0.1-2.0% of medicine gross weight altogether, Margarita layer powder 3-6%, the fermentation residue 85-91% of Semen Glycines and Semen Maydis powder, the sulfate 0.5-1% of ferrum, copper, zinc, the inorganic base 2-4.5% of sodium, magnesium, potassium, sodium, magnesium, potassium, cobaltic chloride account for 1-5%, the hemoporphyrin trace;

(2) 7 kinds of Chinese medicines are pulverized, and granularity is 40-300 μ, and uniform mixing Chinese medicine processing temperature is no more than 70 ℃;

(3) fermentation residue of inorganic base, sulfate, chloride, hemoporphyrin, Semen Glycines and Semen Maydis powder and Chinese herbal medicine-and mixes pulverizing add the Margarita layer powder mixing at last.

2, production method according to claim 1 is characterized in that, can lack the 1-3 kind in 7 kinds of Chinese medicines, and the dosage under lacking must be with several accumulated doses of supplying of remainder.

3, production method according to claim 1 is characterized in that Cortex Cinnamomi can not lack.

4, a kind of application process of preventing and treating fish, shrimp, shellfish, Eriocheir sinensis disease outbreak medicine is characterized in that and medicine can be splashed in water, also medicine can be admixed in the bait and be thrown something and fed.

5, application process according to claim 2, before it is characterized in that medicine is splashed in the water, earlier quicklime is pulverized, granularity 3-350 μ, press quicklime and the mixed of drug weight then than 90: 10, mixed dosage is: treatment 10-20 kg/ha sky (in 2 meters of the depth of waters), prevention 5-10 kg/ha sky; Medicine is water dissolved dilution in container earlier, splashes equably then in the water surface; The next day, splash once, and continuous 3 times is a course of treatment, every month 2 course of treatment.

6, application process according to claim 2, when it is characterized in that medicine is admixed bait, the weight ratio of bait and medicine is 95: 5, with medicine equably mix in bait; The bait feeding amount is 10-20 kg/ha sky, and treatment is identical with the prevention consumption; Continuous 5 days one courses of treatment, every month 2 course of treatment.