CN107088221A - A kind of Chinese herbal medicine for preventing and treating fish trichodinasis, pharmaceutical chemistry and preparation method thereof - Google Patents
A kind of Chinese herbal medicine for preventing and treating fish trichodinasis, pharmaceutical chemistry and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese herbal medicine for preventing and treating trichodinasis, pharmaceutical chemistry and preparation method thereof, the Chinese herbal medicine contains the raw material of following parts by weight：21~30 parts of rhizome of cyrtomium, 27~45 parts of kuh-seng, 30~60 parts of polygonum flaccidum, 24~48 parts of Folium Meliae, clear 20~25 parts of the element of worm, 20~30 parts of ginger, 27~48 parts of allicin.The present invention by pure natural Chinese herbal medicine and feed, glycine betaine, blood meal and flour hybrid process by being made pharmaceutical chemistry and with being not processed into the Chinese herbal medicine of pharmaceutical chemistry with the use of preventing and treating trichodinasis；Chinese herbal medicine and pharmaceutical chemistry of the present invention are safe, available for the production of a variety of fries, to water nonpollution, overcome well the fry phase can not with or the drawbacks of use insecticide with caution, and drug residue free, the resistance to the action of a drug is not resulted in aquatic products, is beneficial to finished product fish culture below, has broad application prospects.
Description
Technical field
The invention belongs to technical field of aquaculture, specifically, disclose a kind of Chinese herbal medicine for preventing and treating fish trichodinasis,
Pharmaceutical chemistry and preparation method thereof.
Background technology
Trichodinasis is the great fish diseases as caused by Trichodina, the fry of a variety of fish of main harm.Trichodina worm
Body side surface is seen such as beaver shape, such as vehicle wheel rotation sample during motion, and that it swells in order to avoid being mouth face, recessed one side is anti-mouth face, its
Conventional attachment disk（Anti- mouth face）It is attached on the gill filament of fish body or skin, and slidably reciprocates, host can be also left sometimes in water
Free swimming, is typically rotated as wheel forward when being swum because of it with anti-mouth, so referred to as Trichodina.
Trichodinasis has generation throughout the year, but using summer and autumn as popular peak period.The suitable water temperature of Trichodina is 20
~28 DEG C, often parasitize in fresh water and seawater fry, fingerling, its spread speed under suitable water temperature is fast, and pathogenicity is strong, polypide
Reliable direct contact infection.Its parasitic site is mainly the gill, skin and other other positions in fish body surface.A small amount of parasitism can influence
Fish body body colour, makes fish lose the appetite or stop ingesting；A large amount of parasitisms can stimulate the gill filament largely to secrete mucus, cause gill epithelium to increase
It is raw, hinder fish body breathing, it is heavy then cause death.
Currently preventing and treating trichodinasis medicine mainly has copper sulphate, mixture of ferrous sulfate, compound benzalkonium bromide, Vetaflavin, generation
Gloomy ammonium, thiram, mercurous nitrate, mercurous acetate, malachite green and formalin etc.（Some drugs have been listed in banning drugs）, and it is many
The current curative effect of these medicines continued to use always over year substantially declines, or even invalid.Although fishing medicine R＆D worker is later successively
The new chemical medicines such as very fine light, Mannich base spermin, biological nicotinoids, carboxylic acid formates are developed, but due to medicament residue,
Toxic side effect, the reason such as cost height, popularization and application area is not wide so far.Therefore, research and development meet Modern Fishery demand for development
Wheel disease protective agents are of far-reaching significance.
The content of the invention
The technical problems to be solved by the invention be overcome in the prior art trichodinasis protective agents prevention effect it is poor, peace
There is provided a kind of Chinese herbal medicine for preventing and treating trichodinasis for the defects such as not high, the easy polluted water of full property and deficiency.The present invention is by by pure day
Pharmaceutical chemistry is made in right Chinese herbal medicine and feed, glycine betaine, blood meal and flour hybrid process and the Chinese herbal medicine with being not processed into pharmaceutical chemistry is matched somebody with somebody
Close to use and prevent and treat trichodinasis；Chinese herbal medicine and the pharmaceutical chemistry prevention effect is good, pollution-free and noresidue, it is ensured that people edible fishes
Food security afterwards.
It is an object of the invention to provide a kind of Chinese herbal medicine for preventing and treating trichodinasis.
It is a further object of the present invention to provide a kind of pharmaceutical chemistry for preventing and treating trichodinasis.
Another object of the present invention is to provide the preparation method of the sick pharmaceutical chemistry of preventing and treating wheel.
The above-mentioned purpose of the present invention is to give realization by the following technical programs：
A kind of Chinese herbal medicine for preventing and treating trichodinasis, the raw material containing following parts by weight：21~30 parts of rhizome of cyrtomium, kuh-seng 27~45
Part, 30~60 parts of polygonum flaccidum, 24~48 parts of Folium Meliae, clear 20~25 parts of the element of worm, 20~30 parts of ginger, 27~48 parts of allicin.
In the present invention in herbal medicine, each component pharmacological property is as follows：The rhizome of cyrtomium property of medicine is bitter, cool, and main component is cotton Ma Su, its
Major function myxosporidiosis, and also have to a variety of therapeutic viruses compared with high inhibition effect；The kuh-seng property of medicine is bitter, cold, main component
For D- matrines and flavones ingredient kuh-seng acid etc., its major function Trichodina, Dactylogyrus and bacillary enteritis and hemorrhagic lose
Blood；The polygonum flaccidum property of medicine is pungent, cold, peppery, and its major function is each infusorians parasite of poisoning and its antidiarrheal；Folium Meliae is bitter, cold, mainly
Composition is each margosine, toosendanin etc., and its major function is stopped blooding for desinsection；Its clear plain major function of worm is that desinsection is antipruritic, analgesia
Anti-inflammatory；The ginger property of medicine is pungent, temperature, and main component is zingiberol, zingiberone, zingiberene etc., and its major function is mainly that antibacterial promotees the effect such as food；
Allicin mainly plays a part of to improve taste, induces and ingest and promote to digest.
In said herbal medicine formula, each component raw material follows property of medicine compatibility and effect combination principle, seven feelings and conjunction, the monarch and his subjects
Assistant makes, and by suitably matching, has reached the effect of Synergistic, and large fresh-water fishes are cultivated according on Guangdong, Hubei and other places（Such as
Carp fry, grass carp seedling, Guangdong triangular bream seedling）, long stern Catfish seedlings, Pelteobagrus fulvidraco seedling, the fresh-water fishes such as mud fish fry and murrel section fish when treatment center
The result of wheel animalcule shows that the Chinese herbal medicine formula can effectively prevent and treat trichodinasis.
Preferably, the Chinese herbal medicine contains the raw material of following parts by weight：25~30 parts of rhizome of cyrtomium, 35~45 parts of kuh-seng is peppery
45~60 parts of knotweed, 35~48 parts of Folium Meliae, clear 22~25 parts of the element of worm, 20~25 parts of ginger, 30~35 parts of allicin.
It is highly preferred that the Chinese herbal medicine contains the raw material of following parts by weight：30 parts of rhizome of cyrtomium, 45 parts of kuh-seng, 60 parts of polygonum flaccidum,
48 parts of Folium Meliae, clear 25 parts of the element of worm, 25 parts of ginger, 35 parts of allicin.
Preferably, all herbal raw materials are required to by picking up impurity, cutting off, the pretreatment such as dry.
The Chinese herbal medicine of the present invention for preventing and treating trichodinasis can be processed further preparing the medicine of preventing and treating Trichodina, therefore,
Sick herbal medicine prevents and treats trichodinasis medicine in preparation in present invention preventing and treating wheel, and prevents and treats trichodinasis effect preparing to have
Feed in application, also all should be in the scope of the present invention.
A kind of pharmaceutical chemistry for preventing and treating trichodinasis, the pharmaceutical chemistry contains the above-mentioned Chinese herbal medicine for preventing and treating trichodinasis.
Further, the pharmaceutical chemistry for preventing and treating trichodinasis is using the Chinese herbal medicine, glycine betaine, blood meal and flour as raw material
It is prepared from.
It is highly preferred that the pharmaceutical chemistry for preventing and treating trichodinasis is using the Chinese herbal medicine, glycine betaine, blood meal and flour as original
Material, is uniformly mixed so as to obtain with forage compounding.Particularly preferably, the pharmaceutical chemistry be by prevent and treat trichodinasis Chinese herbal medicine extract concentration after with
Feed by ratio of weight and the number of copies 1:1000 are well mixed, and added with glycine betaine, blood meal and flour.
Wherein preferably, the usage amount of the glycine betaine, blood meal and flour account for respectively feed and medicament gross weight 0.5~
2%th, 0.5~2%, 1~3%.
It is highly preferred that the usage amount of the glycine betaine, blood meal and flour account for respectively feed and medicament gross weight 1%, 1%,
2%。
Wherein, blood meal and glycine betaine are mainly plaing a part of to improve taste, are inducing and ingest and promote to digest, and flour is to bond
Agent.
Specifically, the above-mentioned pharmaceutical chemistry for preventing and treating trichodinasis includes medicine A and second preparation two parts, by comprising the following steps
Method prepare：
S1. respectively by rhizome of cyrtomium, kuh-seng, polygonum flaccidum, Folium Meliae, the clear element of worm, ginger, allicin crushing, then with ethanol solution 40~
Refluxing extraction is carried out at 60 DEG C, is repeated 3~4 times, extract solution is obtained；It is 1.1 that material concentration is further concentrated to after extract solution is filtered
~1.3g/ml, cooling obtains each raw material extract solution, then it is total medicament that each raw material extract solution, which is mixed,；
S2. step S1 total medicament is divided into A and B two parts, part A is the 1/3 of total medicament, and part B is the 2/3 of total medicament；
Part B is second preparation；
S3. according to 1：600~1500 weight part ratio uniformly mixes part A and feed, adds glycine betaine, blood meal and flour,
Suitable quantity of water is sprayed simultaneously, pharmaceutical chemistry is made, and it is medicine A to air-dry.
Wherein it is preferred to, ethanol solution described in step S1 is the second of 60%~80% concentration of 4 times of bulking values of its raw material
Alcoholic solution.
Preferably, the time of refluxing extraction described in step S1 is 1.5~3h every time（It is preferred that 2h）.
Preferably, the weight part ratio of part A and feed described in step S3 is 1：800~1200.
It is highly preferred that the weight part ratio of part A and feed described in step S3 is 1：1000.
Preferably, the usage amount of glycine betaine, blood meal and flour accounts for the 0.5 of feed and medicament gross weight respectively described in step S3
~2%, 0.5~2%, 1~3%.
It is highly preferred that the usage amount of glycine betaine, blood meal and flour described in step S3 accounts for feed and medicament gross weight respectively
1%、1%、2%。
In addition, a kind of method for preventing and treating fish trichodinasis, i.e., the application method of above-mentioned pharmaceutical chemistry comprises the following steps：Will
Fish culture water level is reduced to 160cm,（According to conventional cultivation water level standard, it is water level reduction by 1/3, i.e., about reduces 80cm water
Position）, first feed part and be not added with the feed of Chinese medicine preparation, then according to accounting for aquatic products gross weight 3%~5%（This is this area
Conventional aquaculture feeds criterion calculation mode）Ratio feed the medicine A of above-mentioned pharmaceutical chemistry, second preparation carried out after 1 hour complete
Splash in pond.
Processing once, i.e., handles, is used in conjunction after 2 days, decides whether again depending on the state of an illness again as stated above again every two days daily
The secondary increase course for the treatment of.
Fry with trichodinasis is after Chinese herbal medicine of the present invention and pharmaceutical chemistry is fed, and the death rate is substantially reduced；Meanwhile,
The fry of trichodinasis is not suffering from after Chinese herbal medicine of the present invention and pharmaceutical chemistry is fed, it also significantly drops by the probability of trichodinasis
It is low；Therefore, Chinese herbal medicine and pharmaceutical chemistry of the present invention have significant effect in terms of fry trichodinasis is prevented and treated.
Preferably, the fry is loach fry or Pelteobagrus fulvidraco seedling.
The product and technique of the present invention be applicable not only to prelarva in pond, postlarva, very little piece, plant fish, each specification fingerling and
Marketable fish, is also applied for other patterns, such as cultivation of interior circulation water, the prevention and treatment of industrial aquaculture and waterwheel in transit.
In addition, in the case of 23 DEG C or so, Chinese herbal medicine and pharmaceutical chemistry of the invention, prophylactic are defined by minimum, controlled
Treat medication maximum amount to be defined, other can suitably adjust by the state of an illness and water temperature etc..
It is also noted that the following aspects in the preparation of this patent Chinese herbal medicine and pharmaceutical chemistry and implementation process：
（1）Implement preferably in the case of fine and water temperature >=21 DEG C；
（2）There is squama fish to can be used for general, but part alepidote need to hold dose and the course for the treatment of with caution；
（3）It should first take certain measure that suspension in water is precipitated or disposed during water turbidity before medication, and should during medication
Turn off into draining；
（4）To avoid the drug effect of this patent Chinese herbal medicine compound impacted, this Chinese herbal medicine should not be with other fishing medicines or other changes
Material is learned to be used together.
The present invention compared with prior art, has the advantages that：
（1）Chinese herbal medicine and pharmaceutical chemistry of the present invention have more security, available for fry production, to water nonpollution, well gram
Taken the fry phase can not with or the drawbacks of use insecticide with caution, and drug residue free does not result in the resistance to the action of a drug to aquatic products, is beneficial to
Finished product fish culture below；
（2）Chinese herbal medicine and pharmaceutical chemistry of the present invention have no toxic side effect to aquatic animal；
（3）Chinese herbal medicine and pharmaceutical chemistry of the present invention are prevented and treated to trichodinasis；
（4）Chinese herbal medicine and pharmaceutical chemistry of the present invention are small compared with chemicals to the destruction of water environment；
（5）Chinese herbal medicine and pharmaceutical chemistry use of the present invention extensively, be applicable not only to prelarva in pond, postlarva, very little piece, plant fish,
Each specification fingerling and marketable fish, are also applied for other patterns, cultivate such as interior circulation water, industrial aquaculture and waterwheel in transit
Prevention and treatment.
Embodiment
The present invention is made below by specific embodiment and further being elaborated, the embodiment is served only for explaining this
Invention, is not intended to limit the scope of the present invention.Test method used in following embodiments is normal unless otherwise specified
Rule method；Used material, reagent etc., are the reagent and material commercially obtained unless otherwise specified.
Embodiment 1
1st, a kind of Chinese herbal medicine for preventing and treating trichodinasis, each component containing following parts by weight：21 parts of rhizome of cyrtomium, 27 parts of kuh-seng is peppery
30 parts of knotweed, 24 parts of Folium Meliae, clear 20 parts of the element of worm, 25 parts of ginger, 30 parts of allicin.
The preparation method of the Chinese herbal medicine for preventing and treating trichodinasis comprises the following steps：
（1）Above-mentioned raw materials rhizome of cyrtomium, kuh-seng, polygonum flaccidum, Folium Meliae, the clear element of worm, ginger, allicin are successively placed in pulverizer and smashed,
And refluxing extraction is successively carried out with the ethanol solution of 60%~80% concentration of its four times of bulking values, repeat 3~4 times, 2 is small every time
When, temperature is 40~60 DEG C, refilters, then concentrates, and is cooled down, and it is about 1.1~1.3g/ml to make density after each raw material concentration, then
It is total medicament that each raw material, which is mixed,；；
（2）By step（1）Total medicament be divided into first and second two parts, first part is the 1/3 of total medicament, and second part is the 2/ of total medicament
3；First part is according to 1 part：1000 weight and feed is uniformly mixed, and adds 2% flour and both gross weights of both gross weights
The blood meal of 1% glycine betaine and both gross weights 1%, while spraying part water, is made pharmaceutical chemistry and then air-dries standby.
2nd, feed in use, first reducing by 1/3 water level（80cm water levels are about reduced, are 160cm to water level）, according to aquatic products
The 3%~5% of gross weight is fed, and is first fed the feed that part is not added with Chinese medicine preparation, is then fed again containing Chinese drugs agentia
Feed, feeds the second medicament that will be left behind after 1 hour and carries out full pool spilling head.
Reuse above-mentioned pharmaceutical chemistry afterwards every two days and handle pond again, be used in conjunction after 2 days, decide whether to increase again depending on the state of an illness
The course for the treatment of.
Embodiment 2
A kind of Chinese herbal medicine for preventing and treating trichodinasis, each component containing following parts by weight：25 parts of rhizome of cyrtomium, 30 parts of kuh-seng, polygonum flaccidum
40 parts, 30 parts of Folium Meliae, clear 25 parts of the element of worm, 20 parts of ginger, 35 parts of allicin；Prepare and application method be the same as Example 1.
Embodiment 3
A kind of Chinese herbal medicine for preventing and treating trichodinasis, each component containing following parts by weight：30 parts of rhizome of cyrtomium, 45 parts of kuh-seng, polygonum flaccidum
60 parts, 42 parts of Folium Meliae, clear 25 parts of the element of worm, 25 parts of ginger, 35 parts of allicin；Prepare and application method be the same as Example 1.
Embodiment 4
A kind of Chinese herbal medicine for preventing and treating trichodinasis, each component containing following parts by weight：28 parts of rhizome of cyrtomium, 28 parts of kuh-seng, polygonum flaccidum
50 parts, 35 parts of Folium Meliae, clear 25 parts of the element of worm, 30 parts of ginger, 48 parts of allicin；Prepare and application method be the same as Example 1.
Comparative example 1
A kind of Chinese herbal medicine for preventing and treating trichodinasis, each component containing following parts by weight：15 parts of rhizome of cyrtomium, 25 parts of kuh-seng, polygonum flaccidum
25 parts, 50 parts of Folium Meliae, clear 30 parts of the element of worm, 20 parts of ginger, 50 parts of allicin；Prepare and application method be the same as Example 1.
Comparative example 2
A kind of Chinese herbal medicine for preventing and treating trichodinasis, each component containing following parts by weight：35 parts of rhizome of cyrtomium, 50 parts of kuh-seng, polygonum flaccidum
30 parts, 35 parts of Folium Meliae, clear 25 parts of the element of worm, 15 parts of ginger, 27 parts of allicin；Prepare and application method be the same as Example 1.
Comparative example 3
A kind of Chinese herbal medicine for preventing and treating trichodinasis, each component containing following parts by weight：25 parts of rhizome of cyrtomium, 35 parts of kuh-seng, polygonum flaccidum
65 parts, 20 parts of Folium Meliae, clear 15 parts of the element of worm, 35 parts of ginger, 20 parts of allicin；Prepare and application method be the same as Example 1.
Comparative example 4
A kind of Chinese herbal medicine for preventing and treating trichodinasis, its component is same as Example 3；
The preparation for preventing and treating trichodinasis Chinese herbal medicine and substantially the same manner as Example 1 with method, difference is each medium-height grass
Grind into powder after medicine raw material is crushed, without refluxing extraction, concentration, but directly carries out next step and prepares pharmaceutical chemistry.
Application examples 1
（1）The last week in White Dew of in September, 2013,9 loach of the aquaculture model household of Jiangxi Fuzhou Shi Dongxiang County one cultivate pond
There is the phenomenon of daily dead 80~120 tail of mud fish fry, on-the-spot investigation is learnt, pond water-soluble oxygen 6.8mg/L, pH7.6, ammonia nitrogen
0.12mg/L, nitrite 0.08mg/L, the index such as hydrogen sulfide 0.06mg/L is in normal range (NR), and mud fish fry food is not good,
It is regular to have in the water surface " waving " or the phenomenon in pond side rubdown；Salvaging the obvious mud fish fry observation outward appearance of illness can obtain
Go out the equal non-evident sympton of mud fish fry mouth, eyes, the gill, skin, fin ray, anus, dissection mud fish fry abdomen observing abdominal cavity and liver, intestines
The equal non-evident sympton of the internal organs such as road, kidney, then microscopy draws in a visual field averagely have under 10 × 10 microscope
15 dolly wheel animalcules are attached on its gill raker, and observation fin ray also has, therefore is diagnosed as trichodinasis.
9 ponds where loach with trichodinasis are divided into nine groups, respectively will above each group it is real according to example 1
Example 2, example 3, example 4, comparative example 1, comparative example 2, contrast row 3, comparative example 4 and the method for blank control use the present invention's
Chinese herbal medicine, is made bait feeding, blank control group only feeds the feed of equivalent by the manufacture craft and feeding method of the present invention.
（2）As a result it is as shown in table 1：
After each test group medication of table 1 in 5 days loach The dead quantity
After medication 1d, first, second, third and fourth group and control group fry The dead quantity are increased slightly（90~140 tails）, control group
Pond fry The dead quantity is dramatically increased（140~170 tails）；After medication 2d, first and second group of fry The dead quantity is reduced（80~
110 tails）, the 3rd group of fry The dead quantity significantly reduce（80 tails）, the 4th group and the continuation of control group pond fry The dead quantity
Increase（140~170 tails）；After medication 3d, first and second group of fry The dead quantity is reduced（50~70 tails）, the 3rd group of fry death
Quantity is significantly reduced（36 tails）, the 4th group of pond fry The dead quantity reduction（115 tails）, control group increases by a small margin（150~
180 tails）；After medication 4d, first and second group of fry The dead quantity continues to reduce（30~50 tails）, the 3rd group of fry The dead quantity be
8, the 4th group of fry The dead quantity is 82 tails, and control group pond fry The dead quantity is 168 tails；After medication 5d, first and second group of fish
Seedling The dead quantity is 30~50 tails, and the 3rd group of fry does not have the discovery phenomena of mortality, and robs food severity, and the 4th group of fry The dead quantity is
75 tails, control group pond fry The dead quantity is sharply increased（350）Tail.
Nursery The dead quantity and blank control using the group five, six, seven, eight of Chinese herbal medicine and pharmaceutical chemistry described in comparative example 1~4
Without significant difference, the increase of fry The dead quantity is notable during medication 1d and 5d, and 2d, 3d and 4d fry The dead quantity have slightly daily
Rise.Show that Chinese herbal medicine formula can reach the effect for effectively preventing and treating trichodinasis only described in the embodiment of the present invention 1~4, its
In, the prevention effect of Chinese herbal medicine is the most notable described in embodiment 3.
Application examples 2
1st, Zhejiang Huzhou in June, the 2014 city water chestnut lake yellow cartfish breeding big specification Pelteobagrus fulvidraco pond of multiple cultivation and big specification grass
The fishpond pool occurrence of large-area phenomena of mortality.Each morbidity fish pond has Pelteobagrus fulvidraco and grass carp seedling travelling one by one from the side of pond
Slowly, it is powerless and float on the surface of the water sometimes " spinning ", detection dissection visible outward non-evident sympton is picked up, only sees that afterbody has hyperemia,
Contain a small amount of food in enteron aisle, whole fish body is faint in color.Microscopy draws visible 8~12 cart wheel animalcules in a visual field, enters one
Step detection water quality draws pond 5~7.2mg/L of water-soluble oxygen, PH6.5~7.5,0.08~0.15mg/L of ammonia nitrogen, nitrite 0.08
The indexs such as~0.12mg/L, hydrogen sulfide 0.06-0.08mg/L are in normal range (NR), therefore preliminary judgement is trichodinasis.
2nd, apply the medicine of the embodiment of the present invention 3 to the Pelteobagrus fulvidraco pond, pharmaceutical chemistry preparation method and application method all with together
Example 1 is identical.
As a result show, do not continue occur the fry phenomena of mortality after medication 4d, 5d Hou Ge pondfish colony's color bases this recoveries is just
Often and to rob food severe, show herbal component of the present invention when preventing and treating trichodinasis, effect significantly, with wide application
Prospect.
Claims (9)
1. a kind of Chinese herbal medicine for preventing and treating trichodinasis, it is characterised in that the component containing following parts by weight：Rhizome of cyrtomium 21~30
Part, 27~45 parts of kuh-seng, 30~60 parts of polygonum flaccidum, 24~48 parts of Folium Meliae, clear 20~25 parts of the element of worm, 20~30 parts of ginger, allicin
27~48 parts.
2. Chinese herbal medicine according to claim 1, it is characterised in that the component containing following parts by weight：Rhizome of cyrtomium 25~30
Part, 35~45 parts of kuh-seng, 45~60 parts of polygonum flaccidum, 35~48 parts of Folium Meliae, clear 22~25 parts of the element of worm, 20~25 parts of ginger, allicin
30~35 parts.
3. Chinese herbal medicine according to claim 1, it is characterised in that the component containing following parts by weight：30 parts of rhizome of cyrtomium, it is bitter
45 parts of ginseng, 60 parts of polygonum flaccidum, 48 parts of Folium Meliae, clear 25 parts of the element of worm, 25 parts of ginger, 35 parts of allicin.
4. Chinese herbal medicine is prevented and treated described in claims 1 to 3 prevents and treats trichodinasis medicine or with preventing and treating trichodinasis effect in preparation
Feed in application.
5. a kind of pharmaceutical chemistry for preventing and treating trichodinasis, it is characterised in that contain any described Chinese herbal medicine of claims 1 to 3.
6. prevent and treat the pharmaceutical chemistry of trichodinasis according to claim 5, it is characterised in that by claims 1 to 3 it is any it is described in
Herbal medicine medicament is prepared from feed, glycine betaine, blood meal and flour.
7. prevent and treat the pharmaceutical chemistry of trichodinasis according to claim 6, it is characterised in that the glycine betaine, blood meal and flour
Usage amount accounts for 0.5~2%, 0.5~2%, the 1~3% of feed and medicament gross weight respectively.
8. the pharmaceutical chemistry of trichodinasis is prevented and treated according to claim 5, it is characterised in that including medicine A and two, second preparation
Point, prepared by the method comprised the following steps：
S1. respectively by rhizome of cyrtomium, kuh-seng, polygonum flaccidum, Folium Meliae, the clear element of worm, ginger, allicin crushing, then with ethanol solution 40~
Refluxing extraction is carried out at 60 DEG C, is repeated 3~4 times, extract solution is obtained；It is 1.1 that material concentration is further concentrated to after extract solution is filtered
~1.3g/ml, cooling, obtain each raw material extract solution, then it is total medicament that each raw material extract solution, which is mixed,；
S2. step S1 total medicament is divided into A and B two parts, part A is the 1/3 of total medicament, and part B is the 2/3 of total medicament；B
Part is second preparation；
S3.A parts are according to 1：600~1500 weight ratio and feed is uniformly mixed, and adds glycine betaine, blood meal and face
Powder, while spray water, is made pharmaceutical chemistry, it is medicine A to air-dry.
9. the pharmaceutical chemistry of trichodinasis is prevented and treated according to claim 8, it is characterised in that ethanol solution described in step S1 is original
Expect the ethanol solution of 60%~80% concentration of 4 times of bulking values.
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| CN107088221B (en) | 2020-08-07 |
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