CN103479850A - Pharmaceutical composition for treating oyster velar virus and preparation method thereof - Google Patents
Pharmaceutical composition for treating oyster velar virus and preparation method thereof Download PDFInfo
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- CN103479850A CN103479850A CN201310387263.8A CN201310387263A CN103479850A CN 103479850 A CN103479850 A CN 103479850A CN 201310387263 A CN201310387263 A CN 201310387263A CN 103479850 A CN103479850 A CN 103479850A
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Abstract
The invention discloses a pharmaceutical composition for treating oyster velar virus, which comprises the following traditional Chinese medicines in parts by weight: 20-30 parts of cinnamon, 15-30 parts of indico naturalis, 2-10 parts of cornel, 15-25 parts of self-heal, 2-10 parts of Fructus Forsythiae and 10-20 parts of garlic. The invention also discloses a preparation method of the pharmaceutical composition. The content of the effective component cassia oil in the cinnamon is 1.4%, and the maximum conversion rate is up to 93.3%. The effective components of the indico naturalis are indirubin and indigotin, wherein the maximum conversion rate of the indirubin is up to 96.8%, and the maximum conversion rate of the indigotin is up to 96.1%. The pharmaceutical composition has better effect on treating oyster velar virus than the traditional western medicine or Chinese and western combined medicine, and the cure rate is up to 100%. The pharmaceutical composition composed of pure traditional Chinese medicine components does not have toxic or side effect on the oysters, and has the advantages of no dependency, high cure rate and no relapse.
Description
Technical field
The present invention relates to treat the field of Chinese medicines of Concha Ostreae disease, be specifically related to a kind of pharmaceutical composition for the treatment of Concha Ostreae face virosis and preparation method thereof.
Background technology
Concha Ostreae face virus (Oyster velar virus disease is called for short OVVD).Virion is 20 body DNA viruses.Ill larva activity goes down, and is sunken to Cultivation container bottom inertia, in visceral mass retraction shell.The face activity is undesired, and the face Epithelial cell loses flagellum, and some cell separation comes, and dense spheroidal Cytoplasm inclusion body is arranged in face, oral area and Esophageal Epithelium cell, and infected cell enlarges, separates.Can contain complete virion in cell separately.
Cortex Cinnamomi, also claim Chinese cinnamon (Chinese cinnamon).Lauraceae (Lauraceae) plant, formal name used at school is Cinnamomum cassia.Bark fragrance, can make spice, distinguishes the flavor of similar to the Cortex cinnamomi japonici (Ramulus Cinnamomi) that originates from the Sri Lanka Cortex Cinnamomi, but pepperyyer, not as good as the Cortex cinnamomi japonici (Ramulus Cinnamomi) deliciousness, and thick than Cortex cinnamomi japonici (Ramulus Cinnamomi).Oleum Cinnamomi has powerful bactericidal action, better than negative patient to the effect of G+ bacteria.
Indigo Naturalis is the Chinese medicinal material that dicotyledonous medicine acanthaceous vegetable acanthaceous indigo, dicotyledon medicine leguminous plant Folium et Caulis Indigoferae Tinctoriae, dicotyledon medicine cruciferae isatis, careless Folium Isatidis or polygonaceae plant polygonum tinctorium ait. leaf food leaf or stem obtain through processing.Indigo Naturalis can be anticancer, and this is that a lot of doctors know, contains the isatin jade in Indigo Naturalis, and animal transplanting tumor is had to good inhibitory action.Indigo Naturalis can resisting pathogenic microbes, for example anthrax bacillus, streptococcus pneumoniae, shigella, vibrio cholera, staphylococcus aureus and Staphylococcus albus etc.Isatin jade in Indigo Naturalis, the indirubin of therapeutic dose can improve the phagocytic function of animal mononuclear phagocyte system, and indirubin has effect to paraplasm granulocyte and oxyphil cell.
Fructus Corni sour in the mouth, adstringency, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, the profuse sweating collapse, interior-heat is quenched one's thirst, for astringent drug, it contains cornin, the not multiple active ingredient such as the iridoid glycosides such as sieve glycoside, Cornuside, sweroside, loganin and Saponin, ursolic acid, tartaric acid, gallic acid, malic acid, Fructus Corni tannin 1,2,3 of sieve glycoside, 7-O-methyl.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, first purpose of the present invention is to provide a kind of pharmaceutical composition for the treatment of Concha Ostreae face virosis.Second purpose of the present invention is to provide the preparation method of this pharmaceutical composition.
Technical scheme: in order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition for the treatment of Concha Ostreae face virosis, comprise following Chinese medicine, its parts by weight are respectively: 20 ~ 30 parts of Cortex Cinnamomis, 15 ~ 30 parts of Indigo Naturaliss, 2 ~ 10 parts of Fructus Corni, 15 ~ 25 parts of Spica Prunellaes, 2 ~ 10 parts of Fructus Forsythiaes, 10 ~ 20 parts, Bulbus Allii.
Preferably, its parts by weight are respectively: 25 ~ 30 parts of Cortex Cinnamomis, 20 ~ 30 parts of Indigo Naturaliss, 6 ~ 10 parts of Fructus Corni, 20 ~ 25 parts of Spica Prunellaes, 6 ~ 10 parts of Fructus Forsythiaes, 15 ~ 20 parts, Bulbus Allii.
More preferably, its parts by weight are respectively: 25 parts of Cortex Cinnamomis, 20 parts of Indigo Naturaliss, 6 parts of Fructus Corni, 20 parts of Spica Prunellaes, 6 parts of Fructus Forsythiaes, 15 parts, Bulbus Allii.
The preparation method of the pharmaceutical composition of described treatment Concha Ostreae face virosis comprises the following steps:
1) take the Cortex Cinnamomi of above-mentioned parts by weight, add 80% ethanol of 8 ~ 10 times of amounts of its weight, adopt supercritical CO
2extraction obtains the effective ingredient of Cortex Cinnamomi;
2) take the Indigo Naturalis of above-mentioned parts by weight, after pulverizing, add the pure water of 10 ~ 15 times of amounts of its weight to put into microwave and clear up 10min, after then adding ultrasonic echography 15min, adopt the water vapour reflux, extract,, extract 5 times, each 2.5h obtains the effective ingredient of Indigo Naturalis;
3) take Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae, Bulbus Allii Cepae and add 20 ~ 25 times of decoctings of Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae and Bulbus Allii Cepae gross weight to boil 2 ~ 4h, filter, obtain supernatant;
4) by effective ingredient, the step 2 of the Pericarpium Granati of step 1)) the effective ingredient of Indigo Naturalis and the supernatant of step 3) mix the pharmaceutical composition of the Concha Ostreae face virosis that obtains medical treatment.
The effective ingredient of described Cortex Cinnamomi is Oleum Cinnamomi.The Oleum Cinnamomi content obtained in described preparation method accounts for 1.0 ~ 1.4% of Cortex Cinnamomi, and conversion ratio has reached 90.2 ~ 93.3%.
The effective ingredient of described Indigo Naturalis is that isatin is beautiful and indigo.The content of described isatin jade accounts for 0.08% ~ 0.30% of Indigo Naturalis, and described indigo content accounts for 1.6% ~ 3.0% of Indigo Naturalis.According to the people such as Liu Zeyu experiment, learn, indigo content is (1.70 ± 0.04) %～(3.33 ± 0.15) %, and the content of indirubin is respectively (0.09 ± 0.01) %～(0.30 ± 0.01) %.Therefore, conversion ratio has reached 88% ~ 96.8%, and described indigo conversion ratio has reached 90.9% ~ 96.1%.
Described supercritical CO
2extraction conditions is: 55 ~ 60 ℃ of temperature, pressure are that 25 ~ 30MPa, extraction time are 1.5h.
Beneficial effect: a kind of pharmaceutical composition for the treatment of Concha Ostreae face virosis provided by the invention, wherein the content of the effective ingredient Oleum Cinnamomi of Cortex Cinnamomi is 1.4%, conversion ratio has been up to 93.3%.The effective ingredient of Indigo Naturalis is that isatin is beautiful and indigo, and the conversion ratio of indirubin has been up to 96.8%, and described indigo conversion ratio has been up to 96.1%.It is better that this pharmaceutical composition is compared the effect of Drug therapy Concha Ostreae face virosis of traditional Western medicine or Chinese medicine and western medicine combination, reached 100% cure rate, and the pure Chinese medicine ingredients of this pharmaceutical composition, not only Concha Ostreae is not had to toxic and side effects, and there is no dependency, cure rate is high, can not recur.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described.
embodiment 1:
A kind of pharmaceutical composition for the treatment of Concha Ostreae face virosis, comprise following Chinese medicine, and its parts by weight are respectively: 20 parts of Cortex Cinnamomis, 15 parts of Indigo Naturaliss, 2 parts of Fructus Corni, 15 parts of Spica Prunellaes, 2 parts of Fructus Forsythiaes, 10 parts, Bulbus Allii.
The preparation method of the pharmaceutical composition of described treatment Concha Ostreae face virosis comprises the following steps:
1) take the Cortex Cinnamomi of above-mentioned parts by weight, add 80% ethanol of 8 times of amounts of its weight, adopt supercritical CO
2extraction obtains the effective ingredient of Cortex Cinnamomi;
2) take the Indigo Naturalis of above-mentioned parts by weight, after pulverizing, add the pure water of 10 times of amounts of its weight to put into microwave and clear up 10min, after then adding ultrasonic echography 15min, adopt the water vapour reflux, extract,, extract 5 times, each 2.5h obtains the effective ingredient of Indigo Naturalis;
3) take Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae, Bulbus Allii Cepae and add 20 times of decoctings of Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae and Bulbus Allii Cepae gross weight to boil 2h, filter, obtain supernatant;
4) by effective ingredient, the step 2 of the Pericarpium Granati of step 1)) the effective ingredient of Indigo Naturalis and the supernatant of step 3) mix the pharmaceutical composition of the Concha Ostreae face virosis that obtains medical treatment.
The effective ingredient of described Cortex Cinnamomi is Oleum Cinnamomi.The Oleum Cinnamomi content obtained in described preparation method accounts for 1.0% of Cortex Cinnamomi, and conversion ratio has reached 90.2%.
The effective ingredient of described Indigo Naturalis is that isatin is beautiful and indigo.The content of described isatin jade accounts for 0.08% of Indigo Naturalis, and described indigo content accounts for 1.6% of Indigo Naturalis.According to the people such as Liu Zeyu experiment, learn, indigo content is (1.70 ± 0.04) %～(3.33 ± 0.15) %, and the content of indirubin is respectively (0.09 ± 0.01) %～(0.30 ± 0.01) %.Therefore, the conversion ratio of described indirubin has reached 88%, and described indigo conversion ratio has reached 94%.
Described supercritical CO
2extraction conditions is: 55 ℃ of temperature, pressure are that 25MPa, extraction time are 1.5h.
embodiment 2:
A kind of pharmaceutical composition for the treatment of Concha Ostreae face virosis, comprise following Chinese medicine, and its parts by weight are respectively: 30 parts of Cortex Cinnamomis, 30 parts of Indigo Naturaliss, 10 parts of Fructus Corni, 25 parts of Spica Prunellaes, 10 parts of Fructus Forsythiaes, 20 parts, Bulbus Allii.
The preparation method of the pharmaceutical composition of described treatment Concha Ostreae face virosis comprises the following steps:
1) take the Cortex Cinnamomi of above-mentioned parts by weight, add 80% ethanol of 10 times of amounts of its weight, adopt supercritical CO
2extraction obtains the effective ingredient of Cortex Cinnamomi;
2) take the Indigo Naturalis of above-mentioned parts by weight, after pulverizing, add the pure water of 15 times of amounts of its weight to put into microwave and clear up 10min, after then adding ultrasonic echography 15min, adopt the water vapour reflux, extract,, extract 5 times, each 2.5h obtains the effective ingredient of Indigo Naturalis;
3) take Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae, Bulbus Allii Cepae and add 25 times of decoctings of Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae and Bulbus Allii Cepae gross weight to boil 4h, filter, obtain supernatant;
4) by effective ingredient, the step 2 of the Pericarpium Granati of step 1)) the effective ingredient of Indigo Naturalis and the supernatant of step 3) mix the pharmaceutical composition of the Concha Ostreae face virosis that obtains medical treatment.
The effective ingredient of described Cortex Cinnamomi is Oleum Cinnamomi.The Oleum Cinnamomi content obtained in described preparation method accounts for 1.4% of Cortex Cinnamomi, and conversion ratio has reached 93.3%.
The effective ingredient of described Indigo Naturalis is that isatin is beautiful and indigo.The content of described isatin jade accounts for 0.30% of Indigo Naturalis, and described indigo content accounts for 3.2% of Indigo Naturalis.According to the people such as Liu Zeyu experiment, learn, indigo content is (1.70 ± 0.04) %～(3.33 ± 0.15) %, and the content of indirubin is respectively (0.09 ± 0.01) %～(0.30 ± 0.01) %.Therefore, the conversion ratio of described indirubin has reached 96.8%, and described indigo conversion ratio has reached 96.1%.
Described supercritical CO
2extraction conditions is: temperature 60 C, pressure are that 30MPa, extraction time are 1.5h.
embodiment 3:
A kind of pharmaceutical composition for the treatment of Concha Ostreae face virosis, comprise following Chinese medicine, and its parts by weight are respectively: 25 parts of Cortex Cinnamomis, 20 parts of Indigo Naturaliss, 6 parts of Fructus Corni, 20 parts of Spica Prunellaes, 6 parts of Fructus Forsythiaes, 15 parts, Bulbus Allii.
The preparation method of the pharmaceutical composition of described treatment Concha Ostreae face virosis comprises the following steps:
1) take the Cortex Cinnamomi of above-mentioned parts by weight, add 80% ethanol of 9 times of amounts of its weight, adopt supercritical CO
2extraction obtains the effective ingredient of Cortex Cinnamomi;
2) take the Indigo Naturalis of above-mentioned parts by weight, after pulverizing, add the pure water of 13 times of amounts of its weight to put into microwave and clear up 10min, after then adding ultrasonic echography 15min, adopt the water vapour reflux, extract,, extract 5 times, each 2.5h obtains the effective ingredient of Indigo Naturalis;
3) take Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae, Bulbus Allii Cepae and add 23 times of decoctings of Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae and Bulbus Allii Cepae gross weight to boil 3h, filter, obtain supernatant;
4) by effective ingredient, the step 2 of the Pericarpium Granati of step 1)) the effective ingredient of Indigo Naturalis and the supernatant of step 3) mix the pharmaceutical composition of the Concha Ostreae face virosis that obtains medical treatment.
The effective ingredient of described Cortex Cinnamomi is Oleum Cinnamomi.The Oleum Cinnamomi content obtained in described preparation method accounts for 1.3% of Cortex Cinnamomi, and conversion ratio has reached 92%.
The effective ingredient of described Indigo Naturalis is that isatin is beautiful and indigo.The content of described isatin jade accounts for 0.27% of Indigo Naturalis, and described indigo content accounts for 3% of Indigo Naturalis.According to the people such as Liu Zeyu experiment, learn, indigo content is (1.70 ± 0.04) %～(3.33 ± 0.15) %, and the content of indirubin is respectively (0.09 ± 0.01) %～(0.30 ± 0.01) %.Therefore, the conversion ratio of described indirubin has reached 90%, and described indigo conversion ratio has reached 90.9%.
Described supercritical CO
2extraction conditions is: 57 ℃ of temperature, pressure are that 27MPa, extraction time are 1.5h.
The embodiment of the present invention 1 ~ 3 any one pharmaceutical composition usage and consumption: at Concha Ostreae face virosis burst period, full pool spilling head, every 1 cubic metre of water body medication 1.5 ~ 2.8g, every mu of pharmaceutical composition 1600 ~ 1800g of the present invention for water body depth of water 1m, be used in conjunction 3 days.
Experimental condition:
The category-A pond: 2 mu of areas, 1.7 meters of depth of water, water source is that Yangtze River Water, pH are 7.0, water temperature is 25 ℃.50 of Concha Ostreaes, average weight are 12g.
The category-B pond: 1.9 mu of areas, 1.6 meters of depth of water, water source is that Yangtze River Water, pH are 7.0, water temperature is 25 ℃.50 of Concha Ostreaes, average weight are 12g.
Test method:
Category-A pond medication 3.5kg, do not have dead Concha Ostreae, and second day medication 3.5kg hides order Concha Ostreae face virosis and improves, the 3rd day medication 3.5kg, and Concha Ostreae face virosis is cured, and diet is normal, moves about freely.
The category-B pond does not have medication, 10 of the dead Concha Ostreaes of first day, and 16 of the dead Concha Ostreaes of second day, within the 3rd day, dead Concha Ostreae is 23.
Result of the test:
The category-A pond does not have dead Concha Ostreae, and cure rate is 100%, the not medication of category-B pond, and mortality rate has reached 98%.
The above is only the preferred embodiment of the present invention; be noted that for those skilled in the art; under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (7)
1. a pharmaceutical composition for the treatment of Concha Ostreae face virosis, is characterized in that, comprises following Chinese medicine, and its parts by weight are respectively: 20 ~ 30 parts of Cortex Cinnamomis, 15 ~ 30 parts of Indigo Naturaliss, 2 ~ 10 parts of Fructus Corni, 15 ~ 25 parts of Spica Prunellaes, 2 ~ 10 parts of Fructus Forsythiaes, 10 ~ 20 parts, Bulbus Allii.
2. the pharmaceutical composition for the treatment of according to claim 1 Concha Ostreae face virosis, it is characterized in that, comprise following Chinese medicine, its parts by weight are respectively: 25 ~ 30 parts of Cortex Cinnamomis, 20 ~ 30 parts of Indigo Naturaliss, 6 ~ 10 parts of Fructus Corni, 20 ~ 25 parts of Spica Prunellaes, 6 ~ 10 parts of Fructus Forsythiaes, 15 ~ 20 parts, Bulbus Allii.
3. the pharmaceutical composition for the treatment of Concha Ostreae face virosis according to claim 1, is characterized in that, comprise following Chinese medicine, its parts by weight are respectively: 25 parts of Cortex Cinnamomis, 20 parts of Indigo Naturaliss, 6 parts of Fructus Corni, 20 parts of Spica Prunellaes, 6 parts of Fructus Forsythiaes, 15 parts, Bulbus Allii.
4. the preparation method of the pharmaceutical composition for the treatment of Concha Ostreae face virosis claimed in claim 1, is characterized in that, comprises the following steps:
1) take the Cortex Cinnamomi of above-mentioned parts by weight, add 80% ethanol of 8 ~ 10 times of amounts of its weight, adopt supercritical CO
2extraction obtains the effective ingredient of Cortex Cinnamomi;
2) take the Indigo Naturalis of above-mentioned parts by weight, after pulverizing, add the pure water of 10 ~ 15 times of amounts of its weight to put into microwave and clear up 10min, after then adding ultrasonic echography 15min, adopt the water vapour reflux, extract,, extract 5 times, each 2.5h obtains the effective ingredient of Indigo Naturalis;
3) take Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae, Bulbus Allii Cepae and add 20 ~ 25 times of decoctings of Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Forsythiae and Bulbus Allii Cepae gross weight to boil 2 ~ 4h, filter, obtain supernatant;
4) by effective ingredient, the step 2 of the Pericarpium Granati of step 1)) the effective ingredient of Indigo Naturalis and the supernatant of step 3) mix the pharmaceutical composition of the Concha Ostreae face virosis that obtains medical treatment.
5. the preparation method of the pharmaceutical composition for the treatment of Concha Ostreae face virosis according to claim 4, is characterized in that, the effective ingredient of described Cortex Cinnamomi is Oleum Cinnamomi.
6. the preparation method of the pharmaceutical composition for the treatment of Concha Ostreae face virosis according to claim 4, is characterized in that, the effective ingredient of described Indigo Naturalis is that isatin is beautiful and indigo.
7. the preparation method of the pharmaceutical composition for the treatment of Concha Ostreae face virosis according to claim 4, is characterized in that described supercritical CO
2extraction conditions is: 55 ~ 60 ℃ of temperature, pressure are that 25 ~ 30MPa, extraction time are 1.5h.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071336A (en) * | 1991-10-10 | 1993-04-28 | 中国水产科学研究院长江水产研究所 | Making, the application process of broad spectrum activity control fish, shrimp, shellfish, Eriocheir sinensis disease outbreak medicine |
| CN1644077A (en) * | 2005-01-11 | 2005-07-27 | 冯绍宽 | Plant additive premixed forage for aquatic culture and bait therefrom |
-
2013
- 2013-08-30 CN CN201310387263.8A patent/CN103479850A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071336A (en) * | 1991-10-10 | 1993-04-28 | 中国水产科学研究院长江水产研究所 | Making, the application process of broad spectrum activity control fish, shrimp, shellfish, Eriocheir sinensis disease outbreak medicine |
| CN1644077A (en) * | 2005-01-11 | 2005-07-27 | 冯绍宽 | Plant additive premixed forage for aquatic culture and bait therefrom |
Non-Patent Citations (2)
| Title |
|---|
| 魏利平等: "贝类幼虫面盘纤毛脱落病的起因及防治", 《海洋湖沼通报》, no. 2, 30 June 1997 (1997-06-30), pages 64 - 69 * |
| 黄小丽等: "中草药免疫增强剂在水产上的开发应用", 《内陆水产》, no. 8, 31 August 2004 (2004-08-31) * |
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Application publication date: 20140101 |