CN107118265A - 用于治疗变态反应的低变应原性杂合蛋白 - Google Patents

用于治疗变态反应的低变应原性杂合蛋白 Download PDF

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Publication number
CN107118265A
CN107118265A CN201610835971.7A CN201610835971A CN107118265A CN 107118265 A CN107118265 A CN 107118265A CN 201610835971 A CN201610835971 A CN 201610835971A CN 107118265 A CN107118265 A CN 107118265A
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allergen
der
polypeptide
class
ige
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Chinese (zh)
Inventor
安德烈斯·阿斯图里亚斯 奥特加 胡安
洛佩兹 德 达瓦里洛 伊纳吉·伊巴罗拉
卡门·阿瑞拉 罗德里格斯 玛利亚
葛雷特 阿尔贝托·马丁尼兹
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Roxall Medicina Espana SA
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Bial Industrial Farmaceutica SA
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Publication of CN107118265A publication Critical patent/CN107118265A/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201610835971.7A 2008-03-25 2009-03-24 用于治疗变态反应的低变应原性杂合蛋白 Pending CN107118265A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200800827 2008-03-25
ES200800827 2008-03-25
CN200980110215.6A CN101977929B (zh) 2008-03-25 2009-03-24 用于治疗变态反应的主要1类和2类螨变应原的低变应原性杂合蛋白

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200980110215.6A Division CN101977929B (zh) 2008-03-25 2009-03-24 用于治疗变态反应的主要1类和2类螨变应原的低变应原性杂合蛋白

Publications (1)

Publication Number Publication Date
CN107118265A true CN107118265A (zh) 2017-09-01

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610835971.7A Pending CN107118265A (zh) 2008-03-25 2009-03-24 用于治疗变态反应的低变应原性杂合蛋白
CN200980110215.6A Expired - Fee Related CN101977929B (zh) 2008-03-25 2009-03-24 用于治疗变态反应的主要1类和2类螨变应原的低变应原性杂合蛋白

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CN200980110215.6A Expired - Fee Related CN101977929B (zh) 2008-03-25 2009-03-24 用于治疗变态反应的主要1类和2类螨变应原的低变应原性杂合蛋白

Country Status (9)

Country Link
US (2) US8951530B2 (https=)
EP (3) EP2436692B1 (https=)
JP (2) JP5793073B2 (https=)
CN (2) CN107118265A (https=)
BR (1) BRPI0908848A2 (https=)
CA (1) CA2718994C (https=)
ES (2) ES2638308T3 (https=)
MX (1) MX2010010353A (https=)
WO (1) WO2009118642A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112313245A (zh) * 2018-05-18 2021-02-02 百明信康生物技术(杭州)有限公司 屋尘螨变应反应的治疗和预防

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EP3266460B1 (en) * 2010-06-03 2023-06-21 ALK-Abelló A/S Pharmaceutical product comprising mite allergen extract(s) and a method for the manufacture thereof
EP2460824A1 (en) * 2010-12-01 2012-06-06 Biomay Ag Hypoallergenic polypeptides for the treatment of house dust mite allergy
CN102676568A (zh) * 2012-05-08 2012-09-19 崔玉宝 一种生产重组粉尘螨变应原Der f1和Der f2融合蛋白的方法
WO2014045084A1 (es) 2012-09-20 2014-03-27 Universidad De Cartagena Proteínas de fusión con representación de diferentes alergenos: propuesta de vacuna para alergia a los ácaros
ES2887409T3 (es) * 2014-12-02 2021-12-22 Taiho Pharmaceutical Co Ltd Proteína de Dermatophagoides farinae novedosa
NL2014882B1 (en) 2015-05-29 2017-01-31 Citeq B V Allergy-specific immunotherapy compositions for use in the treatment of house-dust mite allergy.
MX2018003850A (es) * 2015-09-30 2018-06-15 Boehringer Ingelheim Vetmedica Gmbh Moleculas de transporte de antigeno modular mejoradas y sus usos en animales.
KR101858840B1 (ko) * 2016-01-15 2018-05-16 단국대학교 천안캠퍼스 산학협력단 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제
GB201602850D0 (en) * 2016-02-18 2016-04-06 Bial Ind Farmaceutica S A Fusion proteins
CN108265056B (zh) * 2016-12-31 2019-08-30 江苏众红生物工程创药研究院有限公司 一种重组户尘螨1类变应原蛋白及其制备方法和应用
CN109852652B (zh) * 2017-11-30 2023-05-02 江苏众红生物工程创药研究院有限公司 重组尘螨Ⅰ型变应原Der p1和Der f1蛋白的制备与应用
CN113831400A (zh) * 2021-07-29 2021-12-24 沈阳医学院 一种尘螨致敏蛋白Der p 1的分离纯化方法
CN116063442A (zh) * 2022-09-28 2023-05-05 深圳市龙岗区耳鼻咽喉医院 Der p2的3个B细胞表位肽及其应用

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CN1780852A (zh) * 2003-04-25 2006-05-31 诺和酶股份有限公司 组1螨多肽变体
CN1824291A (zh) * 2005-12-23 2006-08-30 中国农业大学 一种过敏性反应抑制剂
US20070065468A1 (en) * 2005-08-29 2007-03-22 National University Of Singapore Chimeric allergens for immunotherapy

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US5433948A (en) * 1990-02-13 1995-07-18 Thomas; Wayne R. Cloning and sequencing of allergens of dermatophagoides (house dust mite)
US7288256B1 (en) * 1991-10-16 2007-10-30 Merck Patent Gmbh T cell epitopes of the major allergens from dermatophagoides (house dust mite)
GB9724531D0 (en) 1997-11-19 1998-01-21 Smithkline Biolog Novel compounds
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FR2841906B1 (fr) 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
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ITRM20040103A1 (it) 2004-02-27 2004-05-27 Consiglio Nazionale Ricerche Proteine di fusione comprendenti allergeni della famiglia delle ns-ltps, loro usi e composizioni farmaceutiche che le comprendono.
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US20070065468A1 (en) * 2005-08-29 2007-03-22 National University Of Singapore Chimeric allergens for immunotherapy
CN1824291A (zh) * 2005-12-23 2006-08-30 中国农业大学 一种过敏性反应抑制剂

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112313245A (zh) * 2018-05-18 2021-02-02 百明信康生物技术(杭州)有限公司 屋尘螨变应反应的治疗和预防

Also Published As

Publication number Publication date
MX2010010353A (es) 2010-10-05
JP2015164424A (ja) 2015-09-17
WO2009118642A2 (en) 2009-10-01
JP2011517407A (ja) 2011-06-09
EP2436692A3 (en) 2012-06-27
EP2436692B1 (en) 2017-08-02
CA2718994C (en) 2017-06-13
ES2638308T3 (es) 2017-10-19
EP2268662A2 (en) 2011-01-05
EP2436691B1 (en) 2017-08-02
EP2436691A3 (en) 2012-06-27
WO2009118642A3 (en) 2009-12-03
US20150152148A1 (en) 2015-06-04
CA2718994A1 (en) 2009-10-01
US20110052640A1 (en) 2011-03-03
ES2638271T3 (es) 2017-10-19
JP6068544B2 (ja) 2017-01-25
US8951530B2 (en) 2015-02-10
EP2436691A2 (en) 2012-04-04
CN101977929A (zh) 2011-02-16
EP2436692A2 (en) 2012-04-04
BRPI0908848A2 (pt) 2015-12-01
CN101977929B (zh) 2016-10-19
JP5793073B2 (ja) 2015-10-14

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