CN107110807B - 用于检测分析物的方法和系统 - Google Patents

用于检测分析物的方法和系统 Download PDF

Info

Publication number
CN107110807B
CN107110807B CN201580054366.XA CN201580054366A CN107110807B CN 107110807 B CN107110807 B CN 107110807B CN 201580054366 A CN201580054366 A CN 201580054366A CN 107110807 B CN107110807 B CN 107110807B
Authority
CN
China
Prior art keywords
channel
sample
value
electrical
length
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201580054366.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN107110807A (zh
Inventor
苏米塔·彭纳图尔
彼得·约瑟夫·克里萨利
罗纳德·菲利普·基亚雷洛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Alveo Technologies Inc
Original Assignee
University of California San Diego UCSD
Alveo Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/507,818 external-priority patent/US9921182B2/en
Priority claimed from US14/507,825 external-priority patent/US9506908B2/en
Priority claimed from US14/507,820 external-priority patent/US10352899B2/en
Priority claimed from US14/507,828 external-priority patent/US10627358B2/en
Application filed by University of California San Diego UCSD, Alveo Technologies Inc filed Critical University of California San Diego UCSD
Priority to CN202110906985.4A priority Critical patent/CN113834861A/zh
Publication of CN107110807A publication Critical patent/CN107110807A/zh
Application granted granted Critical
Publication of CN107110807B publication Critical patent/CN107110807B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Electrochemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201580054366.XA 2014-10-06 2015-10-05 用于检测分析物的方法和系统 Expired - Fee Related CN107110807B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110906985.4A CN113834861A (zh) 2014-10-06 2015-10-05 用于检测分析物的方法和系统

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US14/507,818 US9921182B2 (en) 2014-10-06 2014-10-06 System and method for detection of mercury
US14/507,820 2014-10-06
US14/507,818 2014-10-06
US14/507,825 US9506908B2 (en) 2014-10-06 2014-10-06 System for detection of analytes
US14/507,828 2014-10-06
US14/507,825 2014-10-06
US14/507,820 US10352899B2 (en) 2014-10-06 2014-10-06 System and method for detection of silver
US14/507,828 US10627358B2 (en) 2014-10-06 2014-10-06 Method for detection of analytes
US14/535,378 US10196678B2 (en) 2014-10-06 2014-11-07 System and method for detection of nucleic acids
US14/535,378 2014-11-07
PCT/US2015/054074 WO2016057422A2 (en) 2014-10-06 2015-10-05 Methods and systems for detection of analytes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202110906985.4A Division CN113834861A (zh) 2014-10-06 2015-10-05 用于检测分析物的方法和系统

Publications (2)

Publication Number Publication Date
CN107110807A CN107110807A (zh) 2017-08-29
CN107110807B true CN107110807B (zh) 2021-08-13

Family

ID=54337888

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202110906985.4A Pending CN113834861A (zh) 2014-10-06 2015-10-05 用于检测分析物的方法和系统
CN201580054366.XA Expired - Fee Related CN107110807B (zh) 2014-10-06 2015-10-05 用于检测分析物的方法和系统

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN202110906985.4A Pending CN113834861A (zh) 2014-10-06 2015-10-05 用于检测分析物的方法和系统

Country Status (13)

Country Link
US (3) US10196678B2 (enExample)
EP (2) EP3901622B1 (enExample)
JP (1) JP6951975B2 (enExample)
KR (1) KR102424219B1 (enExample)
CN (2) CN113834861A (enExample)
AU (2) AU2015328394B2 (enExample)
CA (1) CA2962127A1 (enExample)
ES (1) ES2877076T3 (enExample)
IL (1) IL251440B (enExample)
MX (2) MX384494B (enExample)
RU (1) RU2722853C2 (enExample)
SG (1) SG11201702794VA (enExample)
WO (1) WO2016057422A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
US10352899B2 (en) 2014-10-06 2019-07-16 ALVEO Technologies Inc. System and method for detection of silver
US9506908B2 (en) 2014-10-06 2016-11-29 Alveo Technologies, Inc. System for detection of analytes
US10627358B2 (en) 2014-10-06 2020-04-21 Alveo Technologies, Inc. Method for detection of analytes
US9921182B2 (en) 2014-10-06 2018-03-20 ALVEO Technologies Inc. System and method for detection of mercury
KR102461735B1 (ko) 2016-09-23 2022-11-01 알베오 테크놀로지스 인크. 분석물을 검출하기 위한 방법 및 조성물
CN107643228B (zh) * 2017-08-31 2021-04-27 中国船舶重工集团公司第七一九研究所 一种测量汞蒸气的芯片的制备方法及其传感器的使用方法
JP2022515782A (ja) 2018-12-19 2022-02-22 ニュークレイン リミテッド ライアビリティ カンパニー 分子診断のための装置および方法
AU2019401601A1 (en) 2018-12-20 2021-07-15 Alveo Technologies, Inc. Handheld impedance-based diagnostic test system for detecting analytes
CN110523447B (zh) * 2019-08-29 2021-05-11 苏州大学 一种对细胞多角度力学测量的微流控芯片及其制作方法
US12472492B2 (en) 2020-08-14 2025-11-18 Alveo Technologies, Inc. Systems and methods of sample depositing and testing
KR102618172B1 (ko) * 2020-12-24 2023-12-29 경북대학교 산학협력단 액체의 전기적 특성 측정 시스템 및 액체의 전기적 특성 측정 방법

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5234795A (en) * 1975-06-19 1977-03-16 Nippon Miniature Bearing Co Detecting apparatus for fluid concentration
JPS5914054U (ja) * 1982-07-19 1984-01-27 東ソー株式会社 液体クロマトグラフ用フロ−セル
JPS59139624A (ja) 1983-01-31 1984-08-10 Fujitsu Ltd 試料の加熱方法
GB9318677D0 (en) * 1993-09-09 1993-10-27 Kodak Ltd Method and apparatus for measuring silver ion activity
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US6524532B1 (en) 1995-06-20 2003-02-25 The Regents Of The University Of California Microfabricated sleeve devices for chemical reactions
DE69839709D1 (de) 1997-12-24 2008-08-21 Cepheid Vorrichtung und Verfahren zur Lyse
JPH11241977A (ja) * 1998-02-25 1999-09-07 Shimadzu Corp 流体濃度測定装置
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US6489785B2 (en) 2000-12-05 2002-12-03 Agilent Technologies, Inc. Comparative contactless conductivity detector
US6576459B2 (en) 2001-03-23 2003-06-10 The Regents Of The University Of California Sample preparation and detection device for infectious agents
GB0116384D0 (en) 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
TWI245895B (en) * 2001-11-29 2005-12-21 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array
US20030203504A1 (en) 2002-04-26 2003-10-30 John Hefti Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species
JP4092990B2 (ja) 2002-09-06 2008-05-28 株式会社日立製作所 生体および化学試料検査装置
ITTO20020808A1 (it) 2002-09-17 2004-03-18 St Microelectronics Srl Dispositivo integrato di analisi del dna.
US6875602B2 (en) 2002-09-24 2005-04-05 The United States Of America As Represented By The Secretary Of The Army Portable thermocycler
KR100858080B1 (ko) 2002-11-12 2008-09-10 삼성전자주식회사 전기적 신호를 측정하는 ｐｃｒ 증폭 산물을 검출하는 방법
US7062385B2 (en) 2002-11-25 2006-06-13 Tufts University Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air
EP2388576A1 (en) 2003-08-06 2011-11-23 Bridger Technologies, Inc. Bridged element for detection of a target substance
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
JP2007507689A (ja) * 2003-09-29 2007-03-29 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 標識を用いない生体分子の検出
US6990849B2 (en) * 2004-03-26 2006-01-31 Lifescan, Inc. Microfluidic analytical system with position electrodes
JP3952042B2 (ja) 2004-06-07 2007-08-01 ソニー株式会社 凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるｄｎａチップ
CN102759466A (zh) 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
CN101076608B (zh) 2004-10-18 2013-04-17 布兰迪斯大学 在pcr扩增中提高再现性和降低引物错导的试剂和方法
US8883487B2 (en) 2004-12-23 2014-11-11 Abbott Point Of Care Inc. Molecular diagnostics system and methods
US20060176179A1 (en) 2005-01-26 2006-08-10 Battelle Memorial Institute Bendable, active radio-frequency sensor tags and a system of same
JP2008532005A (ja) 2005-02-25 2008-08-14 インバーネス・メデイカル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 流体ゲート装置
NZ620811A (en) 2005-05-09 2015-09-25 Theranos Inc Point-of-care fluidic systems and uses thereof
US20150141264A1 (en) 2005-05-20 2015-05-21 Apdn (B.V.I.) Inc. In-field dna extraction, detection and authentication methods and systems therefor
RU2423073C2 (ru) 2005-07-14 2011-07-10 Нано-Дайтек Корпорейшн Микрофлюидные устройства и способы их подготовки и применения
WO2007028084A2 (en) 2005-09-01 2007-03-08 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic dna
EP1951860A4 (en) 2005-11-21 2012-06-06 Life Technologies Corp PORTABLE PREPARATION, ANALYSIS AND DETECTION APPARATUS FOR THE TREATMENT OF NUCLEIC ACIDS
US8173077B2 (en) 2005-12-16 2012-05-08 The Curators Of The University Of Missouri Reusable PCR amplification system and method
WO2007092552A2 (en) 2006-02-07 2007-08-16 Antara Biosciences Inc. Device and methods for detecting and quantifying one or more target agents
US20090061450A1 (en) 2006-03-14 2009-03-05 Micronics, Inc. System and method for diagnosis of infectious diseases
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US7708944B1 (en) 2006-06-13 2010-05-04 Research Foundation Of State University Of New York Ultra-sensitive, portable capillary sensor
US20070298487A1 (en) 2006-06-23 2007-12-27 Becton, Dickinson And Company Radio Frequency Transponder Assay
US20120058547A1 (en) 2006-08-11 2012-03-08 The Hong Kong University Of Science And Technology Method and system for nucleic acid detection using electroconductive or electrochemically active labels
GB0618966D0 (en) 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
US20100075312A1 (en) 2006-09-28 2010-03-25 Stokes Bio Limited Qpcr analysis apparatus
WO2008066747A2 (en) 2006-11-22 2008-06-05 The Board Of Trustees Of Michigan State University Electroluminescent-based fluorescence detection device
WO2008070786A1 (en) * 2006-12-06 2008-06-12 The Trustees Of Columbia University In The City Of New York Microfluidic systems and methods for screening plating and etching bath compositions
US7483805B2 (en) 2006-12-26 2009-01-27 Integrated Sensing Systems, Inc. Sensing and analysis system, network, and method
ES2307430B1 (es) 2007-05-09 2009-10-20 Consejo Superior De Investigaciones Cientificas Biosensor y sus aplicaciones.
US8198658B2 (en) * 2007-06-13 2012-06-12 Samsung Electronics Co., Ltd. Device and method for detecting biomolecules using adsorptive medium and field effect transistor
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
BRPI0703025B1 (pt) 2007-08-08 2018-07-17 Universidade De São Paulo - Usp microdispositivo multicamada, processo de preparação de microdispositivo multicamada
MX352987B (es) 2007-10-02 2017-12-15 Theranos Ip Co Llc Dispositivos modulares de punto de cuidado y usos de los mismos.
CL2008003008A1 (es) 2007-10-12 2009-10-02 Bigtec Private Ltd Un micro dispositivo portatil de reaccion en cadena de polimerasa (pcr) basado en un micro chip de ceramica de coccion conjunta de baja temperatura (ltcc) que comprende camara de reaccion, calentador, control de temperatura del calentador, deteccion optica de interfaz de comunicacion, y el metodo para monitorearlo y controlarlo.
US8480980B2 (en) 2007-12-10 2013-07-09 Samsung Electronics Co., Ltd. Thin film bio valve device and its controlling apparatus
US8614059B2 (en) 2007-12-14 2013-12-24 The Johns Hopkins University Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification
US8865401B2 (en) 2007-12-14 2014-10-21 The Johns Hopkins University Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification
DE102007062441A1 (de) 2007-12-20 2009-06-25 Aj Innuscreen Gmbh Mobiles Schnelltestsystem für die Nukleinsäureanalytik
WO2009093838A2 (ko) 2008-01-21 2009-07-30 박막 원심분리 분석 장치 및 이를 이용한 분석 방법
DE102008009920A1 (de) 2008-02-15 2009-08-20 Aj Innuscreen Gmbh Mobiles Gerät für die Nukleinsäureisolierung
KR100969667B1 (ko) 2008-03-24 2010-07-14 디지탈 지노믹스(주) 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩
CN102203284A (zh) 2008-08-14 2011-09-28 赛进有限公司 适于在封闭系统中实施的温度控制的核酸检测方法
JP5717634B2 (ja) 2008-09-03 2015-05-13 ナブシス， インコーポレイテッド 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用
EP2321429B1 (en) 2008-09-03 2016-08-17 Quantumdx Group Limited Methods and kits for nucleic acid sequencing
US8524490B2 (en) 2008-09-18 2013-09-03 X-Bar Diagnostic Systems, Inc. Fully automated portable DNA detection system
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
US20100122904A1 (en) 2008-11-17 2010-05-20 Board Of Regents, The University Of Texas System Incorporating cmos integrated circuits in the design of affinity-based biosensor systems
US8551767B2 (en) * 2008-11-20 2013-10-08 Agency Of Science, Technology And Research Sensor for detection of nucleic acid
WO2010078420A2 (en) 2008-12-30 2010-07-08 Redhorse Fluidics Systems, devices, methods and kits for fluid handling
EP2391883B1 (en) 2009-01-30 2018-03-07 Micronics, Inc. Portable high gain fluorescence detection system
FR2942041B1 (fr) 2009-02-06 2011-02-25 Commissariat Energie Atomique Dispositif embarque d'analyse d'un fluide corporel.
US20100216225A1 (en) 2009-02-25 2010-08-26 Ag-Defense Systems, Inc. Portable microorganism detection unit
US8106428B2 (en) 2009-03-03 2012-01-31 Board Of Regents, The University Of Texas System Nano-scale bridge biosensors
WO2010111605A2 (en) * 2009-03-27 2010-09-30 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
EP2443256A1 (en) 2009-06-15 2012-04-25 BG Research Ltd Nucleic acid detection
KR101217576B1 (ko) 2009-09-22 2013-01-03 한국전자통신연구원 바이오 센서 및 그의 구동 방법
US20110136104A1 (en) 2009-12-04 2011-06-09 Massachusetts Institute Of Technology Multiplexed quantitative pcr end point analysis of nucleic acid targets
KR20110080067A (ko) 2010-01-04 2011-07-12 엘지전자 주식회사 샘플분석 카트리지 및 샘플분석 카트리지 리더
KR102032523B1 (ko) 2010-01-12 2019-10-15 아람 바이오시스템 주식회사 2단 열대류 장치 및 그 사용법
CN102791847B (zh) 2010-01-12 2015-01-21 阿赫姆生物系统公司 三阶段热对流装置及其用途
US10295472B2 (en) 2010-05-05 2019-05-21 Alverix, Inc. Assay reader operable to scan a test strip
CN102004126A (zh) * 2010-05-11 2011-04-06 中国科学院上海应用物理研究所 电化学生物传感器及其检测方法
US20110312650A1 (en) 2010-06-17 2011-12-22 Geneasys Pty Ltd Microfluidic device with optically transparent hybridization chambers for electrochemiluminescent detection of targets
US9029168B2 (en) 2010-06-28 2015-05-12 The Trustees Of Princeton University Use and making of biosensors utilizing antimicrobial peptides for highly sensitive biological monitoring
US8951472B2 (en) 2010-07-19 2015-02-10 Andalyze, Inc. Portable fluorimetric apparatus, method and system
CN103540517B (zh) 2010-07-23 2017-05-24 贝克曼考尔特公司 处理样本的系统及方法
CN103261892A (zh) * 2010-09-02 2013-08-21 海徳诊断学有限责任公司 分析物的电化学检测
US9696299B2 (en) 2010-11-01 2017-07-04 Norberto Guzman Integrated modular unit including an analyte concentrator microreactor device connected to a cartridge-cassette
US8865075B2 (en) 2010-11-01 2014-10-21 Princeton Biochemicals, Inc. Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus
JP2013545475A (ja) 2010-11-30 2013-12-26 クワンタムディーエックス・グループ・リミテッド マイクロ流体多重温度可撓性反応デバイスの設計、製造及び使用
US9877673B2 (en) 2010-12-10 2018-01-30 Clinitech, Llc Transdermal sampling and analysis device
JP2012177599A (ja) 2011-02-25 2012-09-13 Arkray Inc 再生可能なマイクロチップ、それを用いる測定装置、およびマイクロチップの再生方法
WO2012122564A2 (en) 2011-03-10 2012-09-13 Xagenic, Inc. Diagnostic and sample preparation devices and methods
WO2012142192A2 (en) 2011-04-11 2012-10-18 Gray Mark A Apparatus and method for making uniform emulsions
WO2012178210A1 (en) 2011-06-23 2012-12-27 Anitoa Systems, Llc Apparatus for amplification of nucleic acids
US20140349298A1 (en) 2011-07-14 2014-11-27 William Eugene Stanchina Portable, low power instrument for the optoelectronic detection of pathogens using isothermal nucleic acid amplification protocols
US9051605B2 (en) 2011-07-29 2015-06-09 Auburn University Magnetic bead quantum dot nanoparticle assay
US8435738B2 (en) * 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
CN108490204A (zh) 2011-09-25 2018-09-04 赛拉诺斯知识产权有限责任公司 用于多重分析的系统和方法
US9417210B2 (en) 2011-09-30 2016-08-16 Pandora Genomics, LLC System, apparatus and method for evaluating samples or analytes using a point-of-care device
US9030215B2 (en) 2011-10-04 2015-05-12 The Regents Of The University Of California Corporation Real-time, label-free detection of nucleic acid amplification in droplets using impedance spectroscopy and solid-phase substrate
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
WO2013133725A1 (en) 2012-03-09 2013-09-12 Rawle Christopher Bruce Portable device for detecting molecule(s)
US10180421B2 (en) 2012-03-30 2019-01-15 Boston Microfluidics Methods and systems to collect a biological sample
WO2013155213A1 (en) 2012-04-10 2013-10-17 Keck Graduate Institute Of Applied Life Sciences System and cartridge for efficient nucleic acid testing
US10132802B2 (en) 2012-04-17 2018-11-20 i-calQ, LLC Device for performing a diagnostic test and methods for use thereof
US9808798B2 (en) 2012-04-20 2017-11-07 California Institute Of Technology Fluidic devices for biospecimen preservation
CA2870999A1 (en) 2012-04-20 2013-10-24 SlipChip, LLC Fluidic devices and systems for sample preparation or autonomous analysis
US20130309676A1 (en) 2012-05-18 2013-11-21 Alfred E. Mann Foundation For Scientific Research Biased n-mers identification methods, probes and systems for target amplification and detection
EP2895616A1 (en) 2012-09-12 2015-07-22 Xagenic, Inc. Systems, devices, and methods for identifying a disease state in a biological host using internal controls
US20140099636A1 (en) 2012-10-10 2014-04-10 Baker Hughes Incorporated FIELD-BASED qPCR MICROBIAL MONITORING
EP2912432B1 (en) 2012-10-24 2018-07-04 Genmark Diagnostics Inc. Integrated multiplex target analysis
US8956858B2 (en) 2013-03-14 2015-02-17 Src, Inc. Tactical and portable PCR/HRM genome identification system
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
KR20140115210A (ko) 2013-03-20 2014-09-30 한국전자통신연구원 모바일 장비의 앱을 이용한 dna 분석 방법 및 시스템
GB2516666B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd Fluidic cartridge for nucleic acid amplification and detection
EP3030699A4 (en) 2013-08-07 2017-07-26 Xagenic, Inc. Sensor growth controller
US10416109B2 (en) 2013-08-07 2019-09-17 General Atomics Microchip structure and treatments for electrochemical detection
WO2015019195A2 (en) 2013-08-07 2015-02-12 Xagenic Inc. Systems, devices, and methods for deploying onboard reagents in a diagnostic device
CN105593379A (zh) 2013-08-07 2016-05-18 艾克泽基因公司 用辅助寡核苷酸电化学检测的系统、方法和装置
US9735798B2 (en) 2013-08-07 2017-08-15 Xagenic Inc. Precision bipolar current-mode digital-to-analog converter
CA2920621A1 (en) 2013-08-07 2015-02-12 Xagenic Inc. Potentiostat reference electrode interface
JP6673843B2 (ja) 2013-11-17 2020-03-25 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 分子をプローブし、検出し、分析するための光学システム及びアッセイ・チップ
US20170113221A1 (en) 2014-06-11 2017-04-27 Micronics, Inc. Microfluidic cartridges and apparatus with integrated assay controls for analysis of nucleic acids
US9921182B2 (en) 2014-10-06 2018-03-20 ALVEO Technologies Inc. System and method for detection of mercury
US10352899B2 (en) 2014-10-06 2019-07-16 ALVEO Technologies Inc. System and method for detection of silver
US10627358B2 (en) 2014-10-06 2020-04-21 Alveo Technologies, Inc. Method for detection of analytes
US9506908B2 (en) 2014-10-06 2016-11-29 Alveo Technologies, Inc. System for detection of analytes
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
JP6795495B2 (ja) 2014-10-14 2020-12-02 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 微生物を検出するリアクタンス及びキャパシタンス検知プラットフォーム
US10210410B2 (en) 2014-10-22 2019-02-19 Integenx Inc. Systems and methods for biometric data collections
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
KR101709762B1 (ko) 2015-02-09 2017-02-23 광운대학교 산학협력단 생체분자 농축 기능 일체형 센서 및 그 제조방법
CN107849600A (zh) 2015-06-09 2018-03-27 生命技术公司 用于分子标记的方法、系统、组合物、试剂盒、装置和计算机可读媒体
US10303843B2 (en) 2015-08-06 2019-05-28 Microsoft Technology Licensing, Llc Computing system for identifying health risk regions
WO2017106790A1 (en) 2015-12-18 2017-06-22 Clear Gene, Inc. Methods, compositions, kits and devices for rapid analysis of biological markers
EP4556571A3 (en) 2016-02-26 2025-09-03 Abbott Diagnostics Scarborough, Inc. Redox labeled oligonucleotide probes and their use
WO2018017884A1 (en) 2016-07-20 2018-01-25 Genapsys, Inc. Systems and methods for nucleic acid sequencing
KR102461735B1 (ko) 2016-09-23 2022-11-01 알베오 테크놀로지스 인크. 분석물을 검출하기 위한 방법 및 조성물
TW201832726A (zh) 2016-11-01 2018-09-16 美商海科生醫有限責任公司 可基於輸入數據建議檢測之免疫檢測系統
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
AU2019401601A1 (en) 2018-12-20 2021-07-15 Alveo Technologies, Inc. Handheld impedance-based diagnostic test system for detecting analytes
US20220056511A1 (en) 2018-12-20 2022-02-24 Alveo Technologies, Inc. Methods and compositions to reduce nonspecific amplification in isothermal amplification reactions
CA3123832A1 (en) 2018-12-20 2020-06-25 Alveo Technologies, Inc. Methods and compositions for detection of amplification products
AU2019402900A1 (en) 2018-12-20 2021-07-15 Alveo Technologies, Inc. Isothermal amplification with electrical detection

Also Published As

Publication number Publication date
ES2877076T3 (es) 2021-11-16
EP3901622B1 (en) 2023-05-31
CN113834861A (zh) 2021-12-24
RU2722853C2 (ru) 2020-06-04
HK1243489A1 (zh) 2018-07-13
EP3204760B1 (en) 2021-03-17
WO2016057422A2 (en) 2016-04-14
AU2015328394A1 (en) 2017-04-06
US20200277660A1 (en) 2020-09-03
US10626448B2 (en) 2020-04-21
RU2017109736A3 (enExample) 2019-04-11
SG11201702794VA (en) 2017-05-30
IL251440B (en) 2022-02-01
JP2017534064A (ja) 2017-11-16
US10196678B2 (en) 2019-02-05
CA2962127A1 (en) 2016-04-14
US20160130639A1 (en) 2016-05-12
JP6951975B2 (ja) 2021-10-20
WO2016057422A3 (en) 2016-05-26
AU2021203343A1 (en) 2021-06-24
MX2021008520A (es) 2021-08-19
IL251440A0 (en) 2017-05-29
MX384494B (es) 2025-03-14
US11473128B2 (en) 2022-10-18
RU2017109736A (ru) 2018-11-12
AU2015328394B2 (en) 2021-03-04
KR102424219B1 (ko) 2022-07-21
CN107110807A (zh) 2017-08-29
US20190144926A1 (en) 2019-05-16
MX2017003593A (es) 2018-02-01
EP3901622A1 (en) 2021-10-27
AU2021203343B2 (en) 2023-03-30
EP3204760A2 (en) 2017-08-16
KR20170066513A (ko) 2017-06-14

Similar Documents

Publication Publication Date Title
CN107110807B (zh) 用于检测分析物的方法和系统
US9506908B2 (en) System for detection of analytes
US9921182B2 (en) System and method for detection of mercury
US10627358B2 (en) Method for detection of analytes
US10352899B2 (en) System and method for detection of silver
Cadinu et al. Double barrel nanopores as a new tool for controlling single-molecule transport
Vlassiouk et al. Sensing DNA hybridization via ionic conductance through a nanoporous electrode
Petrov et al. Kinetic capillary electrophoresis (KCE): a conceptual platform for kinetic homogeneous affinity methods
Guo et al. Carbohydrate-based label-free detection of Escherichia coli ORN 178 using electrochemical impedance spectroscopy
Purwidyantri et al. Programmable graphene-based microfluidic sensor for DNA detection
JP2018505423A5 (enExample)
Rutkowska et al. Electrodeposition and bipolar effects in metallized nanopores and their use in the detection of insulin
Al Sulaiman et al. Length-dependent, single-molecule analysis of short double-stranded DNA fragments through hydrogel-filled nanopores: A potential tool for size profiling cell-free DNA
US20170114398A1 (en) Systems, methods and devices for detection of nucleic acids
Kim et al. Nanofluidic concentration of selectively extracted biomolecule analytes by microtubules
US20230183779A1 (en) System and method for detection of nucleic acids
HK40064463A (en) Methods and systems for detection of analytes
Shah et al. A universal approximation for conductance blockade in thin nanopore membranes
HK1243489B (zh) 用於检测分析物的方法和系统
Friedrich et al. Improving charge-sensitive biomolecule sensors with the right choice of electrolyte
Basuray Dielectrophoresis and its application to biomedical diagnostics platforms

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1243489

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20210813

CF01 Termination of patent right due to non-payment of annual fee