CN107109373A - 新型噬菌体以及包含其的组合物 - Google Patents

新型噬菌体以及包含其的组合物 Download PDF

Info

Publication number
CN107109373A
CN107109373A CN201580030761.4A CN201580030761A CN107109373A CN 107109373 A CN107109373 A CN 107109373A CN 201580030761 A CN201580030761 A CN 201580030761A CN 107109373 A CN107109373 A CN 107109373A
Authority
CN
China
Prior art keywords
bacteriophage
kccm11466p
enterotoxigenic escherichia
composition
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201580030761.4A
Other languages
English (en)
Other versions
CN107109373B (zh
Inventor
金载沅
申恩美
裴基德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
CJ CheilJedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CJ CheilJedang Corp filed Critical CJ CheilJedang Corp
Publication of CN107109373A publication Critical patent/CN107109373A/zh
Application granted granted Critical
Publication of CN107109373B publication Critical patent/CN107109373B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/40—Viruses, e.g. bacteriophages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/153—Nucleic acids; Hydrolysis products or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10131—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)

Abstract

本发明涉及新型噬菌体ΦCJ28(KCCM11466P)以及包含该噬菌体作为有效成分的组合物。此外，本发明涉及通过使用所述新型噬菌体ΦCJ28(KCCM11466P)或所述组合物预防和/或治疗除人类外的动物的由产肠毒素性大肠杆菌引起的传染病的方法。

Description

新型噬菌体以及包含其的组合物
技术领域
本发明涉及对产肠毒素性大肠杆菌(Enterotoxigenic Escherichia coli，ETEC)具有特异性杀死能力的新型噬菌体、包含其的组合物、以及使用所述新型噬菌体或所述组合物预防或治疗动物的传染病的方法。
背景技术
大肠杆菌(Escherichia coli，下文中称为E.coli)是肠杆菌科埃希氏菌属的革兰氏阴性短杆菌，并且是存在于各种动物(包括哺乳动物)的肠道中的正常菌群之一。已知大肠杆菌的大多数菌株是非致病性的，并且可以引起机会性感染，但一些高致病性菌株在包括人的动物体内引起各种肠道疾病和败血症等。
大肠杆菌可以被分为产肠毒素性大肠杆菌(ETEC)、肠致病性大肠杆菌(Enteropathogenic E.coli,EPEC)、肠出血性大肠杆菌(Enterohemorrhagic E.coli,EHEC)、肠集聚性大肠杆菌(Enteroaggregative E.coli,EAEC)、肠侵袭性大肠杆菌(Enteroinvasive E.coli,EIEC)、产坏死性毒素大肠杆菌(Necrotoxigenic E.coli，NTEC)等，并且具体来说，已知产肠毒素性大肠杆菌在猪中引起大肠杆菌传染病。
目前，随着在养猪业中大规模群养的趋势，猪大肠杆菌病已经成为养猪场中最常见且困扰的疾病。最近，在韩国猪大肠杆菌病的发生也一直增长，由于腹泻而造成小猪的生长迟缓和死亡，这给养猪场造成巨大的经济损失。
尽管在过去已经给猪施加多种抗生素用于预防和治疗这种猪大肠杆菌病，但抗生素的滥用或使用不当会在猪中引发抗生素耐受性或者会引起抗生素残留在猪体内，因此目前在世界范围内对抗生素的施用具有很多限制。
此外，噬菌体是指感染特定细菌并抑制和阻碍所感染的细菌的生长的细菌特异性病毒。由于噬菌体具有比抗生素更强的宿主特异性而且最近出现对抗生素有抗性的细菌的问题日益严重，噬菌体的应用已经引起高度重视。
在许多国家已经积极进行了对噬菌体的研究，并且除了噬菌体的专利申请外，欲从美国食品药品监督管理局(Food and Drug Administration，FDA)获得对使用噬菌体的组合物的批准的举动也呈增加的趋势。
然而，用于预防和/或治疗由产肠毒素性大肠杆菌引起的传染病(该传染病在包括养猪业在内的畜产业中正成为非常重要的问题)的噬菌体相关技术仍然不足，因而需要开发这样的噬菌体及其相关技术。
发明内容
技术问题
作为旨在解决对抗生素有抗性的细菌的出现和肉类中抗生素残留等问题以及有效地预防和治疗由大肠杆菌引起的传染病而进行反复研究的结果，本发明人从自然界分离出一种对产肠毒素性大肠杆菌具有特异性杀死能力的新型噬菌体ΦCJ28(KCCM11466P)。
此外，本发明人鉴定了该新型噬菌体的形态特征、生物化学性质和遗传性质，证实了该噬菌体具有优异的耐酸性、耐热性，从而开发了使用该噬菌体的抗生素、消毒剂、饲料添加剂以及其他组合物，并进一步开发了用于预防或治疗由大肠杆菌引起的传染病的组合物以及使用其来预防或治疗疾病的方法。
本发明的一个目的是提供对产肠毒素性大肠杆菌具有特异性杀死能力的新型噬菌体ΦCJ28(KCCM11466P)。
本发明的另一个目的是提供用于预防和/或治疗由产肠毒素性大肠杆菌引起的传染病的组合物，该组合物包含噬菌体ΦCJ28(KCCM11466P)作为有效成分。
本发明的又一个目的是提供包含噬菌体ΦCJ28(KCCM11466P)作为有效成分的抗生素、饲料添加剂、饮用水添加剂、饲料、饮用水、消毒剂或洗涤剂。
本发明的又一个目的是提供使用噬菌体ΦCJ28(KCCM11466P)或包含噬菌体ΦCJ28(KCCM11466P)作为有效成分的组合物来预防和/或治疗非人类动物的由产肠毒素性大肠杆菌引起的传染病的方法。
技术方案
本发明的一个方面提供对产肠毒素性大肠杆菌具有特异性杀死能力的新型噬菌体ΦCJ28(KCCM11466P)。
本发明的另一个方面提供用于预防或治疗由产肠毒素性大肠杆菌引起的传染病的组合物，该组合物包含噬菌体ΦCJ28(KCCM11466P)作为有效成分。
本发明的另一个方面提供包含噬菌体ΦCJ28(KCCM11466P)作为有效成分的抗生素、饲料添加剂、饮用水添加剂、饲料、饮用水、消毒剂或洗涤剂。
本发明的另一个方面提供预防或治疗由产肠毒素性大肠杆菌引起的传染病的方法，其包括如下步骤：向非人类动物给药上述噬菌体ΦCJ28(KCCM11466P)或包含该噬菌体ΦCJ28(KCCM11466P)作为有效成分的组合物。
有益效果
根据本发明的噬菌体ΦCJ28(KCCM11466P)具有特异性杀死产肠毒素性大肠杆菌的效果。
而且，根据本发明的噬菌体ΦCJ28(KCCM11466P)具有优异的耐酸性和耐热性，并因此不仅能够被用作在各种范围的温度和pH下预防或治疗由产肠毒素性大肠杆菌引起的传染病的物质，而且能够以包含噬菌体ΦCJ28(KCCM11466P)作为有效成分的抗生素、饲料添加剂、饮用水添加剂、饲料、饮用水、消毒剂、洗涤剂等使用。
而且，本发明提供噬菌体ΦCJ28(KCCM11466P)或包含噬菌体ΦCJ28(KCCM11466P)作为有效成分的抗生素，并且具有如下效果：与现有的抗生素相比，对产肠毒素性大肠杆菌的特异性非常高，从而能够仅杀死特定致病细菌而不杀死有益细菌；并且不引发耐药性，这使得与现有的抗生素相比产品市场寿命延长。
而且，本发明具有通过向非人类动物给药该噬菌体ΦCJ28(KCCM11466P)或包含该噬菌体ΦCJ28(KCCM11466P)作为有效成分的组合物来预防或治疗由产肠毒素性大肠杆菌引起的传染病的效果。
附图说明
图1是新型噬菌体ΦCJ28(KCCM11466P)(在下文中被称为“ΦCJ28”)的电子显微镜图。
图2示出了新型噬菌体ΦCJ28的脉冲场凝胶电泳(Pulsed Field GelElectrophoresis，PFGE)结果。
图3示出了新型噬菌体ΦCJ28的十二烷基硫酸钠聚丙烯酰胺凝胶电泳(SodiumDodecyl Sulfate Polyacrylamide Gel Electrophoresis,SDS-PAGE)结果。
图4是示出新型噬菌体ΦCJ28的耐酸性实验结果的图。
图5是示出新型噬菌体ΦCJ28在60℃下的耐热性实验结果的图。
具体实施方式
在下文中，更详细地描述本发明。在本文中将省略对本领域普通技术人员来说显而易见的细节描述。
本发明的一个实施方式提供对产肠毒素性大肠杆菌(ETEC)具有特异性杀死能力的新型噬菌体ΦCJ28(KCCM11466P)(在下文中被称为“ΦCJ28”)。
产肠毒素性大肠杆菌是革兰氏阴性杆菌并且是分解乳糖和果糖以产生酸和气体的需氧或兼性厌氧细菌。产肠毒素性大肠杆菌在普通培养基上也生长良好，并且能够在约7℃至48℃的温度下生长，其中最佳生长温度可以为约35℃至37℃。而且，产肠毒素性大肠杆菌可以在4.5至9.0的pH范围下生长。
由于产肠毒素性大肠杆菌产生与由霍乱弧菌(Vibrio cholera)产生的毒素相似的毒素，因此若感染产肠毒素性大肠杆菌，则表现出与感染霍乱弧菌的情况相似的症状。所产生的毒素能够大致分类为热不稳定肠毒素(heat-labile enterotoxin,LT)和热稳定肠毒素(heat-stable enterotoxin,ST)。热不稳定肠毒素在约60℃下加热约10分钟时失去其活性，而热稳定肠毒素在约100℃下加热约30分钟时也不失去其活性。
产肠毒素性大肠杆菌在小肠的上部增殖，并且当产肠毒素性大肠杆菌的浓度达到每单位体积(1ml)肠液内存在约107菌落形成单位(cfu)至约108cfu时，产肠毒素性大肠杆菌可引起包括大肠杆菌病在内的大肠杆菌传染病。
噬菌体是感染特定细菌并抑制和阻碍该细菌生长的细菌特异性病毒，并且是包含单链或双链脱氧核糖核酸(DNA)或核糖核酸(RNA)作为遗传物质的病毒。
具体而言，根据本发明的实施方式的噬菌体ΦCJ28具有选择性地感染产肠毒素性致病大肠杆菌的种属特异性，并且是具有带有正二十面体头部(icosahedral capsid)且观察到可收缩性尾部的结构的、在形态学上属于肌病毒科(Myoviridae)的噬菌体(参见图1)。对噬菌体ΦCJ28的核苷酸序列与其他噬菌体的解码的核苷酸序列之间的同源性进行比较，并且结果示于表1中。噬菌体ΦCJ28示出在pH 3.0至pH 5.0下稳定的耐酸性，而不会失去活性(图4)，并且在耐热性方面，当暴露于60℃下30分钟时，噬菌体ΦCJ28显示出约1个对数(1log)或更少的活性下降，并且当在相同温度下暴露60分钟或更长的情况下，噬菌体ΦCJ28显示出约3个对数(3log)或更多的活性下降(图5)。噬菌体ΦCJ28的DNA碱基序列展示于序列表的序列号1中。
所述噬菌体ΦCJ28是由本发明人分离出的一种新型噬菌体，并且在2013年10月25日保藏于韩国微生物保藏中心(Korean Culture Center of Microorganisms，KCCM)(首尔市西大门区弘济1洞361-221)，保藏号为KCCM 11466P。
本发明的另一种实施方式提供用于预防或治疗由产肠毒素性大肠杆菌引起的传染病的组合物，其包含噬菌体ΦCJ28作为有效成分。
由于噬菌体ΦCJ28展现出能够特异性杀死产肠毒素性大肠杆菌的抗菌活性，噬菌体ΦCJ28能够被用于预防或治疗由感染产肠毒素性大肠杆菌而引起的疾病。待被用噬菌体ΦCJ28预防或治疗的由产肠毒素性大肠杆菌引起的传染病的例子包括但不限于大肠杆菌病(Colibacillosis)、特别是猪大肠杆菌病(Colibacillosis in pigs)。
本文中，术语“大肠杆菌病”指的是由于动物体内感染致病性大肠杆菌而发生的疾病，并且其症状包括败血症、腹泻(新生期腹泻和断奶后腹泻)、毒血症(水肿和脑脊髓血管病)等。其中，败血症是具有极高死亡率的急性全身感染，其主要发生在出生后两到三天内的新生期。腹泻是经常在一周至两周龄内的哺乳期间发生以及在断奶后立即发生的肠道感染症状，其是死亡或发育障碍的一个原因。毒血症主要发生在8周至12周龄的仔猪断奶后，并且经常可在出现水肿和神经症状后引起猝死。
本文中，术语“预防”指的是通过给动物施用噬菌体ΦCJ28和/或包含噬菌体ΦCJ28作为有效成分的组合物抑制相应疾病或者延缓相应疾病发生的所有措施。
本文中，术语“治疗”指的是通过给动物施用噬菌体ΦCJ28和/或包含噬菌体ΦCJ28作为有效成分的组合物改善或减轻已感染的相应疾病的症状的所有措施。
根据该实施方式的用于预防或治疗由产肠毒素性大肠杆菌引起的传染病的组合物可以包含5×102pfu/ml至5×1012pfu/ml、具体而言1×106pfu/ml至1×1010pfu/ml的噬菌体ΦCJ28。
根据该实施方式的用于预防或治疗由产肠毒素性大肠杆菌引起的传染病的组合物还可以包含药学上可接受的载体，并且可以与载体一起配制以提供食品、药物、用于饲料的添加剂或用于饮用水的添加剂等。本文中，术语“药学上可接受的载体”指的是不刺激生物体并且不抑制给药化合物的生物活性和性质的载体或稀释剂。
适用于该实施方式的载体的类型不受特别限制，并且可以使用本领域中常用的任何药学上可接受的载体。载体的例子可以包括但不限于，盐水、无菌水、林格氏溶液、缓冲盐水、白蛋白注射液、葡萄糖溶液、麦芽糖糊精溶液、甘油和乙醇。这些载体可以单独使用或两种以上混合使用。
此外，根据需要，可以向根据本发明的组合物中添加其他常见添加剂，例如抗氧化剂、缓冲溶液和/或抑菌剂，并且还可以向根据本发明的组合物中添加稀释剂、分散剂、表面活性剂、粘合剂和/或润滑剂，来配制可注射制剂(例如水溶液、悬浮液和乳液)、丸剂、胶囊、颗粒或片剂。
根据该实施方式的用于预防或治疗由产肠毒素性大肠杆菌引起的传染病的组合物的给药方法不受特别限制，并且可以使用本领域中常用的任何方法。给药方法的非限制性示例可以包括口服给药或肠胃外给药。
用于口服给药的剂型的非限制性示例可以为锭剂(troches)、糖锭(lozenges)、片剂、水溶性悬浮液、油性悬浮液、配制粉末、颗粒、乳液、硬胶囊、软胶囊、糖浆或酏剂等。
为了将根据该实施方式的组合物配制成诸如片剂或胶囊的剂型，还可以包含粘合剂，例如乳糖、蔗糖、山梨醇、甘露醇、淀粉、支链淀粉、纤维素和明胶；赋形剂，例如磷酸二钙；崩解剂，例如玉米淀粉和甘薯淀粉；润滑剂，例如硬脂酸镁、硬脂酸钙、硬脂酰富马酸钠和聚乙二醇蜡；等等，并且对于胶囊剂型来说，除了上述物质外，还可以进一步包含液体载体(例如脂肪油)等。
肠胃外给药该实施方式的组合物的方法可以使用例如静脉内给药、腹腔内给药、肌内给药、皮下给药或局部给药等，此外，可以使用将所述组合物涂覆或喷射到疾病部位的方法，但不限于此。
为了配制肠胃外给药剂型，例如可以将该实施方式的组合物配制成用于注射的剂型，例如皮下注射、静脉注射和肌肉注射；栓剂；或者用于喷雾的剂型，例如气雾剂，从而允许通过呼吸器吸入，但不限于此。为了配制用于注射的剂型，可以将该实施方式的组合物与稳定剂或缓冲剂在水中混合，以制备溶液或悬浮液，该溶液或悬浮液被配制成用于单位施用的剂型，例如安瓿或小瓶。当组合物被配制成用于喷雾的剂型(诸如气雾剂)时，组合物可以与推进剂等一起与添加剂配制，以使分散于水中的浓缩物或者润湿粉末分散于其中。
除了配制组合物的方法、给药方法、给药时间和/或给药途径外，根据不同的因素，例如作为给药对象的动物的年龄、体重和性别、疾病症状的程度、所摄入的食物、排泄速率等，改变根据该实施方式的用于预防或治疗由产肠毒素性大肠杆菌引起的传染病的组合物的适当的涂覆、喷射或给药量。而且，本领域技术人员能够容易地确定和指定对所预期的治疗有效的给药量。
本发明的另一实施方式提供包含噬菌体ΦCJ28作为有效成分的抗生素。
本文中，术语“抗生素”指的是以药物形式施用于包括人的动物并具有杀灭细菌的功效的制剂，而且其被用作防腐剂、杀菌剂和抑菌剂的总称。
该实施方式的包含噬菌体ΦCJ28作为有效成分的抗生素所具有的效果是：与现有抗生素相比，该抗生素相对于产肠毒素性大肠杆菌的特异性非常高，并因此仅杀死特定的致病细菌，但不杀死有益细菌；并且该抗生素不引发耐药性，这使得与现有抗生素相比产品市场寿命延长。
本发明的另一实施方式提供饲料添加剂或饮用水添加剂，其包含噬菌体ΦCJ28作为有效成分。
饲料添加剂或饮用水添加剂可以通过如下来使用：使用噬菌体ΦCJ28或包含其的组合物分别制备饲料添加剂或饮用水添加剂，并将饲料或饮用水与添加剂混合，或者在制备饲料或饮用水的过程中直接添加噬菌体ΦCJ28或包含其的组合物。
以根据该实施方式的饲料添加剂或饮用水添加剂的形式使用的噬菌体ΦCJ28或包含噬菌体ΦCJ28作为有效成分的组合物可以是液体形式或干燥形式，例如干燥粉末形式。
例如，基于饲料添加剂的重量，根据本发明的噬菌体ΦCJ28可以以粉末形式、以0.05重量％(wt％)至10wt％、具体地0.1wt％至2wt％的组分比混合。
用于干燥根据该实施方式的饲料添加剂或饮用水添加剂以得到干燥粉末的方法不受特别限制，并且可以采用本领域中常用的任何方法。干燥方法的例子可以包括通风干燥、自然干燥、喷雾干燥和冷冻干燥，但不限于此。这些方法可以单独使用或者两种以上组合使用。
根据该实施方式的饲料添加剂或饮用水添加剂还可以包含其他非致病性微生物。微生物可以选自由如下组成的组：枯草杆菌，例如能够产生蛋白酶、脂肪酶和/或糖基转移酶的枯草芽孢杆菌(Bacillus subtilis)；乳酸菌，例如在厌氧条件(例如牛的胃)下具有生理活性和有机物分解能力的乳杆菌(Lactobacillus sp.)；丝状菌，例如米曲霉(Aspergillus oryzae)，其具有增加家畜的体重、增加牛奶产量以及增加饲料的消化吸收率的效果；以及酵母，例如酿酒酵母(Saccharomyces cerevisiae)，但不限于此。这些微生物可以单独使用或两种以上组合使用。
根据需要，根据该实施方式的包含噬菌体ΦCJ28作为有效成分的饲料添加剂或饮用水添加剂可以进一步包含其他添加剂。可用的添加剂的非限制性示例可以为为了防止饲料或饮用水质量下降而添加的粘合剂、乳化剂、防腐剂等；为了增加饲料或饮用水的效用所添加的氨基酸、维生素、酶、益生菌、调味剂、非蛋白含氮化合物、硅酸盐、缓冲剂、着色剂、萃取剂或寡糖等；除此之外还可以包括饲料混合剂等。这些添加剂可以单独使用或两种以上组合使用。
基于100重量份的饲料，根据本发明的饲料添加剂可以以0.05重量份至10重量份、具体地0.1重量份至2重量份的量存在。基于100重量份的饮用水，根据本发明的饮用水添加剂可以以0.0001重量份至0.01重量份、具体地0.001重量份至0.005重量份的量存在。在这些范围内，添加剂允许噬菌体ΦCJ28对抗产肠毒素性大肠杆菌的活性被充分显示出。
本发明的另一实施方式提供通过向饲料或饮用水添加包含噬菌体ΦCJ28作为有效成分的饲料添加剂或饮用水添加剂或者向饲料或饮用水中直接添加噬菌体ΦCJ28制备得到的饲料或饮用水。
在该实施方式中使用的饲料不受特别限制，并且可以使用本领域中常用的任何饲料。饲料的非限制性示例可以为植物性饲料，如谷物、根菜、食品加工副产物、藻类、纤维、医药副产物、油脂、淀粉、粕类或谷物的副产物等；和动物性饲料，如蛋白质、无机物、油脂、矿物质、油脂、单细胞蛋白和动物性浮游生物或食品。这些饲料可以单独或两种以上组合使用。
在该实施方式中使用的饮用水不受特别限制，并且可以使用本领域中常用的任何饮用水。
本发明的另一实施方式提供包含噬菌体ΦCJ28作为有效成分的消毒剂或洗涤剂。消毒剂或洗涤剂的剂型不受特别限制，并且可以使用本领域中常用的任何剂型。
为了去除产肠毒素性大肠杆菌，可以将消毒剂喷洒于动物的活动区域、屠宰场，死亡区域、烹饪场所和烹饪设备等，但不限于此。
洗涤剂可以被用于洗涤暴露于或可能暴露于产肠毒素性大肠杆菌的动物的皮肤表面或身体各部位等，但不限于此。
本发明的另一实施方式提供使用噬菌体ΦCJ28或包含噬菌体ΦCJ28作为有效成分的组合物预防或治疗由产肠毒素性大肠杆菌引起的传染病的方法。
具体而言，该实施方式的预防方法或治疗方法包括向感染产肠毒素性大肠杆菌或具有感染产肠毒素性大肠杆菌的危险的非人类对象给药药学有效量的噬菌体ΦCJ28或包含噬菌体ΦCJ28作为有效成分的组合物的步骤。每天噬菌体ΦCJ28或包含其的组合物的合适总量可以由医生在适当的医学判断范围内确定，这对于本领域技术人员来说是明显的。
噬菌体ΦCJ28或包括噬菌体ΦCJ28作为有效成分的组合物针对特定动物的具体的药学有效量可以通过考虑如下内容来确定：要实现的反应的种类和程度，相应个体的年龄、体重、一般健康状况、性别、饮食，噬菌体ΦCJ28或包括其的组合物的给药时间和给药途径，以及组合物的分泌率，治疗时期等，并且根据包含同时使用或者不同时使用的其他药物组合物的成分的各种因素和在医学领域中公知的相似因素，来改变上述具体的药学有效量。
噬菌体ΦCJ28或包含噬菌体ΦCJ28作为有效成分的组合物可以以药物制剂的形式喷雾式鼻腔给药至动物或者直接添加到动物的饲料或饮用水并使动物摄食该饲料或饮用水而给药至动物，并且可以以饲料添加剂或饮用水添加剂的形式与饲料或饮用水混合，然后给药至动物。
噬菌体ΦCJ28或包含噬菌体ΦCJ28作为有效成分的组合物的给药途径和给药方法不受特别限制，并且可以使用任何给药途径和给药方法，只要该给药允许噬菌体ΦCJ28或包含其的组合物到达相应的组织即可。即，噬菌体ΦCJ28或包含噬菌体ΦCJ28作为有效成分的组合物可以通过各种口服途径或非肠道途径来给药，该给药途径的非限制性示例可以为口服给药、直肠给药、局部给药、静脉内给药、腹腔内给药、肌内给药、动脉内给药、经皮给药、鼻内给药和吸入给药。
下文中，将通过实施例更详细地描述本发明。然而，这些实施例仅用于示例性地说明本发明，而不用于限制本发明的范围。
[实施例1]–感染产肠毒素性大肠杆菌的噬菌体的分离
<实施例1-1>
噬菌体筛选和单噬菌体分离
将从忠清道洪城郡广川区的Samhwawonjong(三和原种)公司农场区的猪粪和环境样品获得的50ml样品在4000rpm的转速下离心分离10分钟，然后将所获得的上清液通过0.45μm过滤器过滤，以制备样品溶液，使用该样品溶液执行顶层琼脂法(soft agaroverlay method)。顶层琼脂法是指使用在顶层琼脂(使用0.7％琼脂放置在固体培养基上)上生长的宿主细胞观察噬菌体溶菌的方法。
具体而言，将150μl的由首尔大学兽医学院的兽医传染病实验室分离的产肠毒素性大肠杆菌(2618)的振荡培养液(OD600＝2)和2ml的10×LB培养基(10g/l的色氨酸；5g/l的酵母提取物；10g/l的NaCl)与18ml的经过滤的样品溶液混合，然后在30℃下培养18小时，并将所获得的培养液在4000rpm的转速下离心分离10分钟，并且将所获得的上清液通过0.45μm过滤器过滤。随后，将3ml的0.7％(w/v)琼脂和150μl的产肠毒素性大肠杆菌(2618)的振荡培养液(OD 600＝2)的混合液倒在LB平板培养基上并使其固化，向其逐滴添加10μl的样品溶液，然后在30℃下培养18小时，从而确认形成溶菌斑。
由于已知每个溶菌斑均存在一种噬菌体，发明人尝试从所形成的溶菌斑分离单一的噬菌体。具体而言，将溶菌斑添加至400μl的SM(悬浮培养基)溶液(5.8g/l的NaCl；2g/l的MgSO47H2O；50ml的1M三羟甲基氨基甲烷-盐酸(Tris-HCl，pH 7.5))，并在室温下放置4小时，从而获得噬菌体溶液。随后，将100μl的噬菌体溶液与5ml的0.7％(w/v)琼脂和150μl的产肠毒素性大肠杆菌(2618)的振荡培养液(OD600＝2)混合，并使用直径为150mm的LB平板培养基执行顶层琼脂法，其中进行培养直至完全溶菌。培养完成后，向LB平板培养基添加5ml的SM溶液，并在室温下放置4小时，从而获得噬菌体溶液。
回收所述溶液并添加1％(v/v)氯仿，并混合10分钟，然后在4000rpm的转速下离心分离10分钟，从而获得上清液，将该上清液通过0.45μm过滤器过滤，从而获得最终试样。
<实施例1-2>
噬菌体的大规模培养和纯化
使用产肠毒素性大肠杆菌(2618)大规模培养在实施例1-1中获得的噬菌体，然后从中纯化噬菌体。
具体而言，振荡培养产肠毒素性大肠杆菌(2618)，并以1.0×1010cfu分株，在4000rpm的转速下离心分离10分钟，然后使其再悬浮于4ml的SM溶液中。在该悬浮液中以1.0×107pfu接种所述噬菌体，滴定所述噬菌体至感染复数(multiplicity of infection，MOI)＝0.001后，在室温下放置20分钟。接着，将其接种在150ml的LB培养基中，并在30℃培养5小时。
培养完成后，添加氯仿最终体积的1％的体积(v/v)，接着搅拌20分钟，向其中以1μg/ml的最终浓度分别添加作为限制酶的脱氧核糖核酸酶I(DNase I)和核糖核酸酶A(RNaseA)，并在30℃下放置30分钟。随后，分别以1M和10％(w/v)的最终浓度添加氯化钠和聚乙二醇，并在4℃下放置3小时，然后在4℃和12000rpm的转速下离心分离20分钟，从而获得沉淀物。
使获得的沉淀物悬浮在5ml的SM溶液中，在室温下放置20分钟，然后向其中添加1ml的氯仿并搅拌，在4℃下以4000rpm的转速离心分离20分钟，从而获得上清液。将该上清液通过0.45μm过滤器过滤，然后使用甘油密度梯度法(密度：40％，5％甘油)执行超离心分离(35000rpm，1小时，4℃)，从而纯化噬菌体。
本发明人从猪粪收集样品，并从该样品分离出对产肠毒素性大肠杆菌具有特异性杀死能力的噬菌体，将该噬菌体命名为“噬菌体ΦCJ28”并于2013年10月25日保藏于韩国微生物保藏中心(首尔市西大门区弘济1洞361-221)，保藏号为KCCM 11466P。
<实施例2>
ΦCJ28的形态检查
将实施例1中所纯化的噬菌体ΦCJ28稀释于0.01％明胶溶液中，然后用2.5％戊二醛溶液固定。将所获得的噬菌体滴加至涂覆有碳的云母板(大约2.5mm×2.5mm)上，驯化10分钟，然后用无菌蒸馏水洗涤。将碳膜插入铜网中，用2％乙酸铀酰染色60秒，干燥，并在透射电子显微镜(JEM-1011，80kV，放大倍数为200000)下检查(图1)。
图1示出噬菌体ΦCJ28的透射电子显微镜照片，其中观察到噬菌体ΦCJ28在形态学上具有正二十面体头部和可收缩性尾部，由此可知噬菌体ΦCJ28属于肌病毒科。
<实施例3>
ΦCJ28的全基因组DNA的尺寸分析
从实施例1中纯化的噬菌体ΦCJ28中提取基因组DNA。
具体而言，向经纯化的噬菌体ΦCJ28的培养液中，添加20mM乙二胺四乙酸(Ethylenediaminetetraacetic acid，EDTA)、50μg/ml蛋白酶K和0.5％(w/v)十二烷基硫酸钠(sodium dodecyl sulfate，SDS)，并在50℃下放置一个小时，向其中添加等体积的苯酚(pH 8.0)并搅拌，随后在室温和12000rpm的转速下离心分离10分钟，从而获得上清液。
将上清液与等体积的PC(苯酚:氯仿＝1:1)混合，随后在室温和12000rpm的转速下离心分离10分钟，从而获得上清液。将上清液与等体积的氯仿混合，随后在室温和12000rpm的转速下离心分离10分钟，从而获得上清液。将上清液与基于总体积的10％(v/v)的3M乙酸钠混合，随后添加2倍体积的95％冷乙醇，混合并在-20℃下放置1小时。在0℃和12000rpm的转速下将所获得的物质离心分离10分钟，从中去除上清液以获得沉淀物，将沉淀物溶解于50μl的TE缓冲溶液(Tris-EDTA,pH 8.0)中。将提取的DNA稀释10倍，然后通过在OD260下测量吸光度来确定DNA的浓度。
接下来，将1μg的DNA加载到1％脉冲场凝胶电泳(pulse-field gelelectrophoresis，PFGE)琼脂糖凝胶上，并使用伯乐(BIORAD)公司PFGE系统7号程序(尺寸范围从25kb到100kb；转换时间斜度(switch time ramp)从0.4秒到2.0秒，线性；正向电压，180V；反向电压，120V)在室温下进行电泳20个小时(图2)。
图2是噬菌体ΦCJ28的基因组DNA的电泳照片，并且可以看出，噬菌体ΦCJ28的基因组DNA尺寸为98kb以上。在图2中，M为作为用于尺寸测量的基准的DNA。
<实施例4>
ΦCJ28的蛋白质图谱分析
将15μl的经纯化的噬菌体ΦCJ28溶液(1010pfu/ml效价)与3μl的5×SDS样品溶液混合，然后煮沸5分钟，以进行12％SDS-PAGE(图3)。
图3是示出以噬菌体ΦCJ28为对象进行的SDS-PAGE结果的电泳照片，并且可以看出主要蛋白质具有约67.9kDa、约50.8kDa和约6kDa的尺寸。
<实施例5>
ΦCJ28的遗传特性分析
为了确定实施例1中所纯化的噬菌体ΦCJ28的遗传特性，使用FLX TitaniumSequencer(Roche公司)作为基因分析仪来分析噬菌体ΦCJ28的DNA。在Macrogen公司使用GS和de novo assembler software(Roche公司)重组基因。使用GeneMArk.hmm,Glimmerv3.02和FGENESB软件执行开放读码框架(open reading frame)。使用BLASTP和InterProScan对读码框架的名称进行命名。
噬菌体ΦCJ28的核苷酸序列显示出与之前报道的噬菌体(肠杆菌噬菌体Bp7)的核苷酸序列相似性，但可以看出没发现其中所有片段100％一致的噬菌体。因此，可以看出，该噬菌体是新分离的噬菌体。
下表1示出了噬菌体ΦCJ28的核苷酸序列与现有技术中之前报道的噬菌体的解码的核苷酸序列之间的比较结果。
表1
使用基因分析仪分析所制备的噬菌体ΦCJ28的DNA的全核苷酸序列结果与序列号1相同。
<实施例6>
ΦCJ28的pH稳定性研究
为了鉴定噬菌体ΦCJ28是否能够在低pH(如肠胃内)下保持稳定性，在多种pH(pH2.0、3.0、4.0、5.0)下执行稳定性研究实验。
为了该实验，分别以0.2M的浓度制备多种pH溶液(乙酸钠缓冲溶液(pH 4.0和pH5.0)和柠檬酸钠缓冲溶液(pH 2.0和pH 3.0))。
将180μl的各pH溶液与20μl的具有2.9×109PFU/ml效价的噬菌体溶液混合，以允许每个pH溶液具有1M的浓度，然后将所获得的溶液在室温下放置2小时。对于对照组，通过相同的方法将20μl的具有2.9×109PFU/ml效价的噬菌体溶液与180μl的SM溶液混合，然后将所获得的溶液在室温下放置2小时。此后，分阶段地稀释这些溶液，并且利用顶层琼脂法分别将10μl各阶段的稀释液在30℃下培养18小时，通过是否溶菌来确定效价(图4)。
图4示出了噬菌体ΦCJ28的耐酸性的实验结果。在图4中，可以看出与对照组相比噬菌体ΦCJ28在pH 3.0至pH 5.0下没有失去其活性且保持稳定。
<实施例7>
噬菌体ΦCJ28的热稳定性研究
如果在噬菌体的众多剂型中，噬菌体被配制成饲料添加剂，在配制过程中可产生热量，因而为了确定噬菌体的热稳定性进行如下实验。
具体而言，将200μl的具有2.9×108PFU/ml浓度的噬菌体ΦCJ28溶液在60℃下分别放置0分钟、30分钟、60分钟和120分钟。此后，将获得的实验培养液分阶段地稀释，并且利用顶层琼脂法分别将10μl各阶段的稀释液在30℃下培养18小时，通过是否溶菌来确定效价(图5)。
图5示出了噬菌体ΦCJ28的耐热性的实验结果。如在图5中所示，可以看出噬菌体ΦCJ28在60℃下暴露30分钟时示出约1个对数(1log)以下的活性损失，并且当噬菌体ΦCJ28暴露60分钟或更长时，活性损失3个对数或更多。
<实施例8>
针对野生型分离菌株产肠毒素性大肠杆菌的噬菌体ΦCJ28的感染范围研究
除了本实验中所使用的产肠毒素性大肠杆菌(2618)外，还对99株由首尔大学兽医学院、建国大学兽医学院和韩国动植物检疫局(KAPQA)分离的野生型分离菌株(即产肠毒素性大肠杆菌)，确认噬菌体ΦCJ28是否具有溶菌活性。分离的菌株由37株F-血清型F4型、30株F5型、7株F6型、20株F18型和5株其他菌株组成。
具体而言，将150μl的每个菌株的振荡培养液(OD600＝2)混合，并向其滴加10μl的具有109pfu/ml效价的噬菌体ΦCJ28溶液，且通过在30℃下进行顶层琼脂法18小时来培养，观察是否形成溶菌斑。
结果示于表2中。
表2
如表2中所示，噬菌体ΦCJ28展现出感染F-血清型F4、F5、F6、F18型的能力，这些是在一般的养猪场中引起猪腹泻的主要病原性细菌，因此预期展现出优异的功效。
序列目录Free Text(自由文本)
在所附的序列表中提供。
申请人或代理人档案号P14-5112 国际申请号
关于微生物或其他生物学物质的保藏的说明
(PCT细则13之二)
PCT/RO/134表(1998年7月，2004年1月再版)
序列表
<110> CJ第一制糖株式会社
<120> 新型噬菌体以及包含其的组合物
<130> P14-5112
<150> KR 10-2014-0042911
<151> 2014-04-10
<160> 1
<170> PatentIn version 3.2
<210> 1
<211> 171499
<212> DNA
<213> 新型噬菌体CJ28
<400> 1
aaatacgttg ggtccaaccc attgaatatg caaccattat atcactcatt tcaataagcg 60
ttttggctgc ttcaaaagtc attacattag aggtttccgc tgtttgggtg aatttaccgt 120
ccatggagtg gatataatgg tcataatgaa tctgggtatc ttgctcgttt aaatcaaact 180
tgacaaagca acgtttttcc tcggacaatc cacgaacacg gttagtaata gtatcccaat 240
attcatcgat gtaaatacct tcaagagaaa aagcttcatg ctcgttaaga ttagacttga 300
caatttcaat aatatctgaa ggcttaagac ctgattcaag aagctcttgg attttagcca 360
atttctcagc attgccttga gggtccattt tatcaaattt tttagcttct tcaaaatgtt 420
gctcagggcg agcactcaca cctttaccaa agtagaaagg ttttttgttt tcatctacta 480
aacgatatac ctgataaatt gtttcttgat tgtaagccat tttaaatctc ctttagttga 540
taggtctata gtatcatgcc tacaggagat gtaaactgat tttataaata ttaatttaac 600
aggaggataa catgggcagt attttttacc aaatctggaa attggccgaa aagaaagaca 660
agaaaatgat gttaggtttt cttgcactag atgtattcct ttggaatctt ctggtagtcc 720
ctgtagccgc tagtcaaggt gtaattttac cagcggttac aatggagcac gtgttaagca 780
tagttgggtt ctttagcgga attcctgcct aaatcttgga atattttgaa agtctcattt 840
ttgccattaa accttgggct atattagctt tcatatatgc cagtacatca tttatatcgg 900
ctttatcttt cataaccata tcatttatat ctttagaagg ccatggggcc ttgtcccaga 960
atagaaccct ttcgccagca tcaactaatc gttgcatacg cttaattgtg tcaggatggc 1020
ggggttcatt gtccattacc caggcacgag tttctttaca tggaactata gccaagtcca 1080
atgacccacc agtaattgct attgcattcg gtacgaataa tgaatcgata ggaccttcca 1140
ttacccacac caactgacgt tcgtcaactg tatccattcc atatattttt gtagcttggt 1200
catgagcttt tattgtaata tatttttgtg gagcgtcttt acgtaaggct cgaccctgaa 1260
aactttcaat ttgtttattc ttattgaaaa ttggaataac caaacgaggc tcaggcattt 1320
ctttagaata ggtccctgga ttgacagagt tcaccaatgc aggccattct ttagtaaacc 1380
acagccggtt ccatttgttt tcaggaatgc aacgtaacgt cacatatttt ataataggat 1440
ggtccttcgg cattctatct aatcgttcac agaaattaag cttttcgatg acaggcatct 1500
tagctttaat tttttcagat atctccacct taggtgcagc ttgtctcccg aacgattgct 1560
ctttatgttt ctcaagaata tattcacgat ataaatcagg ctcatattcg tatagatact 1620
tcttaattcc tgctgaataa tcacagttaa aacagtgcag cataatagag ccgtcattgg 1680
caggataggc ccaaaaacga gctttgttct catctttttg ggagtcaccg catacacgac 1740
aacggcagtt taatttaaaa tcactaccag ttacttgtct gaatttaggt tggtaattca 1800
aggcacgtac agcaaattct ttatcgacat atgacattat ttttccttgg gccctaaatt 1860
aatagagcca ttatatcatt cgttttcgga tttttcttta cgctttttag atgggatttg 1920
ttcaggccct ttgttgacga ccgcgcctga ggtagttccg gaggcaatag cagtaggatt 1980
accacctgca tcgcctgcga ccatatcttc gttcataact tctttaaaag atttcatagg 2040
ctcctggcct tatttatatt acgaaaatag ctttatcacc atttgcatca gtgacttcat 2100
aggtatcttc gtggtaaagt ggaataatcc aagtcgcacc atcaccagca ataatatgga 2160
tagcttcttg gtcttttgat acgatttcat attcttcgaa taattcgaat acagaaatct 2220
tagagcccgt acacattgca ctcatattgt tcccttcttt taatcagttg gcgatgagcc 2280
tttttaagtt tacgaagctg acgtttagtt ggccgtgcaa cataagcttg agtagttact 2340
cgtccaaaaa caccgtactt aggtgaagga gaatcgataa agacttccca ctgacaagag 2400
taactataca cggctttaga gaattgagtt aagacaaaca tattaacctc gattcataaa 2460
agcattaaaa atttggtcat caattgaata aaccggggct tccagaattt tcaacagact 2520
gtttttgata tacttgctag ggatatccat attaacgcca tcattcaatt cgttgtccgg 2580
gaggatatct ttaaattcga atccatcaaa ctcaaccttg tcaggaatac cttcagcgaa 2640
aaaataaacc aattggtgca ttgtattgca tgaaaataat ttagacctca ccgcaataag 2700
ttcttgccaa tggtttaatt ctctgttaag aagtttatga gccattgtaa ttcgatcatc 2760
actatcaaca agaaaataac ccaggtattg gtggtcgtcg ctccaaaaca tcctgtatgc 2820
ttgtgcattt ggatttttac aacgaagctt tttaataact aaatttctgt taatcttatt 2880
cacctgtcac ctctttaacg atatttttgt tatcgaaatt ggcatcacaa tacaaaacat 2940
agttatattg cataacacca cctgaagcta attggtctga cacttcttta gccatatcag 3000
ggcggtcacg tttagtgatg ttcatgatat cagcataaat ctgatgttca accgattctt 3060
ggtctgcagt catagaccat tcacaaaggt ctttatccaa tccggccgtt accggagccg 3120
tgccacatga tgctactgta aggattgctg cgattaataa ctttttcatt tttaactcct 3180
cgttagttga taggtccata gtatcactac catagaccgt tgtaaacttt attttaacga 3240
atcttctaaa taaattttac ggaatttacg ttttgtctgg cgaatctgac gcttagtagg 3300
cttcacagga aattcgaaga actctacgta ttcttgttca taatcattgt gaccgactga 3360
aagaactagt tcccagttgc ttacagtacg ttggataaac atattatgct taccaaaaga 3420
tttgttccaa aaagaactgg gagttggttt cattagtacg atattcattt attcctcgcc 3480
ttcatgttta tgggcaattt cttcgaattc gttgtcacag tctatacagg ttgcattgtc 3540
ccaagcatca aataccgctt ggtcttcgcg gaccgaacaa ccacatacta cacactcaac 3600
ttcttccatt tagatttcct caatacgggc atcatgttca taaacttcta cgtcgtcgac 3660
atacgcctta accaaaatac tattgacttc agcgaattgg gtagtcaccc acacgatatc 3720
gttttcacgc actgaagctt ctttggtagc ggtatcgccg ttggtgaaat ggccgacaaa 3780
ttttacttta attgattcag acatttagat ttcctcacag aaggcccatt cagcatgata 3840
aaccgtagcg cctttagtat catttaaaca aatcacatct accggagcaa ttacacgata 3900
aagacgaggt tctcctccca ctgaacgagc tgcacgtcca gcataaatct tagccaaacc 3960
gatatcttca gtaaagaaca cacgatttag gtttttctta cgaccggttt cagacaaaac 4020
tcctgtttcc tcaggaggac aaagcatatt accgatatta gcaacactac aacttccatg 4080
ataatacact ttatattctg ctttacagtc gatggttttc attttgttct ccaagttgat 4140
aggtctatag tatcacgcct acaggagatg taaaccctta aaaacaaaaa aggagccgaa 4200
gctccttaaa atttgataga tgctgctaaa tcgtccaaat cacttctatt aacacgcgtc 4260
tgtcgattga cctcggcctg tcgattcatc tcacctgtag cctcacgaac agtgttcact 4320
ggacctggat tggaatcgtc ttcaacttcg taccaacgtt gatttccttt cttaacacca 4380
atcttaaatt tgttgtagta gctcttatcg ccataacgag atttaagctg cttaaccatc 4440
tgcataccca tctgagcaaa ctcttctgtc tcgaccacac ctaacatgaa gtctgcagta 4500
tgtgcaatac caaaggattc agcaatatca gccatatcga tttcggctgc aacgttcgca 4560
ccacgagtag tctgggctgc tgtccacagc aataatttct tctctactgc aagcccacgt 4620
agttcttcgg cgaccatctt aatcaatccg taactgtttt cagagaaaac tttcgtacgg 4680
gatgatgcac agatagccaa gtagtcaacg ataaccacct gagggacaaa gttttgtttg 4740
agcttgtatt cgtttaataa tgcacggaat gtatcggcat tcgcaccgcc agtaggatac 4800
tgtttaatct ttaaacgacc taaggtagca gttgaacgcc atttatccat cttagcttta 4860
tattcaggcc aagagacgtg accatcatca atatcgtcta gtgatacatc cagaaggttg 4920
gcgtcgatac gcttagcaca tacttcctct gccatctcca tggagatata aagaacatcg 4980
tatccagatt gaagataatc agcagccaat gaacaaagac caagagactt acctacgttt 5040
gttcctgcca acaatacgtt ttcagtacca aactcggcgc cgcccttggt aatcttattc 5100
agaatattaa gacggaatgg aaccttacgt gctttatcgg aataactttt gaatcgttct 5160
tcatagtcat ccatccagtc atgacctaat tcagaatcga aacaaatcga taatgcatca 5220
cgcatgatat ccggaatggc accgatacct ggaagttttc tattttgttg ctcaaccgga 5280
aggtcggcat tagtttggat ttcaatgatt tttgaagttg cattatacat cgctgctttc 5340
tgaacgtatt tctccgtctc tttaaccaac cattcttggt cttcaggtcc ggcattcagt 5400
gaacttaaaa gctctttagc gccttggtgt tcaacttctg aaagcgtact gttatctaac 5460
gcaatactca atgcattctt agaaggcact gcattatatt cattgacgtg ttttttaatt 5520
tctttgaaaa gggtctttgc aggaccctgg tcaaaataag aatcattcat ataaggccag 5580
accttagtga aataatcact attgcctagc agttgagcca aaatagtttc taccacttcc 5640
accacctctt agatttaatt ttatccagtt cttcttgtat ttgcattgta acacattttt 5700
ctacatgaag cgctagctct tcttttcggt cttcggaagg tgttccgaaa tcaaccgaca 5760
cttttccatc tttctcaata acaatattca tcacataaac gatgtgagca gtgccatcgg 5820
gtaaagtaag cataatttcc tgcttaaccg aacccattga cttacggatt atatctaatg 5880
atttctcata ataacgaggg tcactaggac cctcttcggt atctttaaca aaattatcta 5940
aatcagataa atcagtcatg gtcactcaca aaattcatat tttctaaatc gttttcgata 6000
tcagcagcgc tttgggtatt tccacctaat ttaacagcaa cgttcttaga gacacgagag 6060
ttaataaggt cgttcactgc atcgtcaact tctttaatag aattaattgc accgagctta 6120
tacttattct cgattgcttc acggaacggg gcatgtttaa acagcggtcc ccagaactca 6180
acacaatcgg tagctttagc acgccatgct ttttcttctt gaaccatttc gcctgtggtt 6240
tcgtcaagga atgcacgatt ataccaacca gctttaggtt tcacgacaaa gccgatatca 6300
gtagccattt caagcaatcc actgaatggg tcgataccgc cttcaaagtt aacggtgata 6360
gggaacgttg atttctcttt aaccgtacga gatttctcag ccttcagtgt aaagtcataa 6420
cctgtgagct cggtaccatc tttaacctga cgtttagaga taaagaacac ggtagaagca 6480
gagtacagaa taccagtacc accacccata atctctttag gatacattcc accaatttcc 6540
atagccgtat ggttgattgc tacacaaggg atatccttga tggtcagata aggcgttacg 6600
atacggaaca gagatttcag tgacttagca cgggtcatat cacctacaac tttctcgttc 6660
aaagcatctt cggtttcttt cttagaagcg gtgttaccaa tggagtcgat aaagataata 6720
accttttcgc cacgagtaat ttcttctaac tggttggtca tatcaacttt aagctgttcg 6780
actgactgga ttggtgtatg aaccacacgt tccaaatcaa cacccatcga acggaaataa 6840
gattctgaag caccaaactc agagtcatag aacaaacaaa ttgcgtctgg atatttcttc 6900
atatacgccg caaccatggt aagtccgaac aacgttttaa agtgtttaga tggagcagca 6960
aagattgtca aacctgattg taagcctgca ttcaacgcac cacctaatgc aatattcagc 7020
atagggatac gagtaggaac ttcgtcacga ccattaaaca atttagattt ggtcaggtcg 7080
gcagtcattt tagaagtaga agctttaatc aaacgggatt ttaaatcgga cattatattt 7140
ttccataggc accattatat tttactcacg ttttaagata gggtaattat atcacttcac 7200
atttacagcg ttaaaggacc acgtcctcat aacttggcat ttcgtgctca gaatggatat 7260
gggcaccgaa ataaatgaat tcagccagac caggatggaa tactaaaccg ggattctcat 7320
gataaatgat atgaggtctt gatttcagaa tctgataata ttcaacctta ctcggtttga 7380
atttaataat ctctacatca ggacgatagt tttcgcgctt aaatgaatca ttcgggtcgg 7440
taatataaag tcgagcacct tcagccgcag cttggtctac aactctttcg aattgataac 7500
atttatctga gatacggaac ggatggaaaa taccatcaat tttaataggc gctagacctt 7560
cagagtaacg ctcaattacc gccggattaa ttaccttttg gtctacaaaa atcttatcag 7620
aggacgcacc tcgtgacacc aggacgtctt tctggcattg attcaggact gtagtataaa 7680
tcgaacgttc aactgaagac acgtcggtat caatgaactc atcgatgtaa taacgaggaa 7740
cttcagggtc cattgtaatg ttaaagttga attgtacagt ctgagtgcca tcataacctg 7800
tgatatcggt tactaatcct gagcagtcat agtattcgat taacgaatca acaacgaact 7860
cattttcaga ccaaaaatgt ttacgggttt cataagcatt ttctttatac caaagtggta 7920
cgaaattcag ttcagggaac aattcaatac attctttgat atcgctcgaa tttctaggat 7980
aagccagata atcacctggg cgagcacggt ttaaatggag ttgaaaatta ccgtccttaa 8040
ggacggcata ttcacctgtt tcgtaactac gcatactgaa aataggaacg ataaacagac 8100
tcatttcagg aatcctcgaa cgtagtcaaa atcacgttca aatacatgtg cactaaccat 8160
agtatgggaa tacgtaccca gaccaacacc acactgttca gcaataaagg ccatcagttt 8220
accctgcaga tagaaatcca gctgcataac gatagcacag ttctgtgaac gcatatgagt 8280
gtgtgcatac agacgtccat cacgaatata atatgttacc gaatcggtac atggatattc 8340
tagggattcg tcagaatcaa ggagggcttg gtcttgttct tggagaattt ggaacacaac 8400
tcgtctcgag ttaggctttt ctttaagctc tttaagtagg gctgggagtt gggccacaat 8460
tcgaggtcca tagaaagtgt tgaagtttgc aggcaatacg tcacttttcg gcttatcaat 8520
gaacttagca acattaggat attccttaaa tgcttcggcg gcgtcagtac caccagaaat 8580
cataaatttc cagaaagatt cggcataatc atagttgata cgattaatac gagggtcggt 8640
gaatttatag gtgcttgcat ccagtacttc taccgaagca gaaccaattt cataacaacg 8700
gccgatacga gaatcaactg caaactgtgg agcttccagg atttcttcgt tcatttgctt 8760
aaacgcgttt tcaaaactaa cagcggtaat gtgtttcatt tattcacctt attttcaata 8820
tattcattca gacgttttaa ttctaccata tcgacgttaa gcaagttatt atggccgtcg 8880
tgatttaaga ttttaaacac gttttcaaaa catgtttcat attgccggat agttagattg 8940
aactcatctt tggttaattt aataaggtcg tcttcgaagt cttcatctaa tgggttacgg 9000
gttaaaataa cctcaataat attgaattca gatttaaacc ctttccaatc ttccagttct 9060
acataagggt ccatttcacc acgaaggaat ccagagtaaa caatattact aggatatcca 9120
cggtctaaga tgtagacaaa attagggtct aaaaacttat ataaggtttc gactaaagcc 9180
ttatcgttat cagtccctaa tgaaatgcat ttgccattaa tctttttagg aaaatcaata 9240
agacgatatt tcttatcaga taaaagtgat tcaattaaag tagacttccc ggaattatcc 9300
gggccgtcga taacaattat ttttggtttc acggatgata tgccttatag gtttcaagag 9360
ttccttcacg aaccatttct ttaaagtggt caggtcggat tgctcggtca tcgatgataa 9420
aagtataact cggcttatgt gtaagcagat tatgatattt caatccaatc ttttcaaggt 9480
tcttaaccaa tgcaggaact acttcaacca agattcgacc aggtccacat gaagtcatac 9540
cacgagcagt gaacaacgta atctcataac cttcatcata aagcttatta atcatggaca 9600
ccatttcggt gtctggttta aagttttcat aatcacggtc gtggttccaa accgtgattg 9660
tattatcgat gtcaaaacat aaatggggct tattttctac tcgatgcgac attaaatttt 9720
cttccattgt ttgtggagtt cagtagaacc cgtaggttta tattttacac cagtttctcg 9780
gtcaagcaaa acccacttat caggacaacg agtaataatt tgagccgtaa tagggtcgcg 9840
aacttcatca acgaattcac ctgtgataag cttacgctta cgaggatgcc gcttcagcag 9900
cacactcagt tgatataaac cattgtaata agcacccaga gctttcagag ggttattttt 9960
aaagtaacct gccaatgcca tccagataac agcaatccag agcttgtgct taaatgtaca 10020
cattggaata tcatctaaag gcataacctt ttcaatatca acgaatacac gagttccgtt 10080
acgagttaag ccgccccata gagggtcaga gttaaatttg tcataaccgt cgatagaata 10140
aagcacctta gcttcgtcat aaatcgcagg gcctttagaa ctattaccaa aataaccacg 10200
tgggtcgatg attttaatat caccttcgtc cgacaacata atattactgt agtgcgggtc 10260
accatgaata agttggtacg gttctttatg ttcagacaga atttctagtg catgacgaag 10320
aagtttttct gggtcgccta ccttaaagtc attgacatgg gtaatgccct gtggagcaaa 10380
gccttcaatc aatccggcaa tagaagcatt acgaatcagg accttgtcca atacttcttt 10440
cttaacatca gaataccatt gctcatcgga tggattatcg atagttccac cgaatgaacg 10500
caatgcacta acgaccttat aaaccatgag gactttagtt tctttagaca taaaccggta 10560
ggcatctgcc atggtgcgac caaagatacg ttccatttta atgaattcac ccggagcaaa 10620
gtctacaatg ctcggaacga attcagaatc aatagaattg taccaattga tttctttaga 10680
ttggatttct ttacctaatt cgttggtagg tactttaatg gccagattct cagtgaactc 10740
taatttatta aattcacggt taatttcaga atcttcatgg gccttagcca gtttcaattt 10800
gtcaccgaca tcaactacaa agtccagctt acgttctgtc aaatggacca ttgaatccag 10860
gttgtcggca aggtcttcgc cataatacag actgttaaaa cctgtccaat tggctacttg 10920
atacaaacca actacaccac cgccagtacc aatttcacgc aagtacggtt cttcaaatgt 10980
aaaacgacag tcagtcccgt aggtataaca gtagtcatta tcccactcaa ctttatgacc 11040
ctcaggaatg atgtcacacc agttaaacag gacattgtgc ccgatgatat cttcagcaat 11100
gcaatcgata gcatgagctg aaccattggc cacatctacg ttacgaatag tgaatttagg 11160
cttatcacta ttaatcatgt taatggattt aatatagcct ttaacgaggt cgttaaattt 11220
gctgtgaata accagaataa tttcatctga ttggttacta tacaaatcat acaaatgttt 11280
taatactgta tgctgtttgt agttaaccaa taccttaggg atttcgttag taattggata 11340
caaccgtgag ccaagacccg cgcctaaaat aacaaccttt ttcattatct gttcctcaag 11400
tgaatgtagg tacattatac actattttta ataaattggt attgcttaaa tcttatcttt 11460
accgatttcg atgcactgtt ctattgctgc tggcactttg gtcttgagct tattgatttg 11520
tttcttataa tcacgggctt tatcgaaact ctcggtttcg agcatttcgt aataacgagc 11580
ctcatggata gaaatctgta gattgatatg atttacgcac atcgcataca gtttctgttt 11640
tttgtacaaa tcgtcttgac gcttcatttc tgcctggtgt ttggctagta ccgcttcacg 11700
cttggactct tgttcgcgtt ggaattcgat ttccctttga gcatattttg cacagttatt 11760
accacattga ttattagctc gggtgtacac aagtccagaa cctgcacgga atttcatttc 11820
gccatcgaat tgtttctgtt cagctgcgat acgagcttta ccaacttcat cggccgaaac 11880
tgcatcacca tattggactg cgcaacctga taggagcata ctcattgcga taattaactt 11940
tttcataata tcctcaatta aaacagttat acttaatttg tgctataaga ataatccatc 12000
cgatgattag tgtcggaatc attggtggaa ttgccactgc ccaataaacg gtaaaggcgg 12060
tcattataag aaataaaata attattttca ttgcttaaca ataatgattt gcgcgtttga 12120
tttacgttca gcgacgatag cccatattaa agccactacc caaccaatca tcgtccaacc 12180
caacaggaga ttaaggaaga aaattcctac attactacga gtgcctcgca gaagagctaa 12240
aatccatggt aaaaagtaac cgatgaacat aatagccaga gaaccaaatc ctaaaacacc 12300
agcactaacg attaaagctt ccattgtaat ttcctcatgt agttgatagg aaggatacta 12360
ccacgttcca tgtggtatgt aaacacttaa aagtcgaaca tatcaaataa tgttgctttt 12420
ttctcgtagt cgattttagc agattcagta aaaccggtca gaggcttgat aaaggtcttt 12480
tggaaaagta cgttgtagtc catccaacgg aggacttggt cacgaatctg aaccggaagt 12540
tcaatacctg atggccatgc catacaagct tcaccaaacg ggttgccttc tttaagcggc 12600
agtacatata ccttttcacc atcaacgata cgaggcatag tcaaatcacc tgcagaagca 12660
cgcatgtaag ctaagcaacc tttgatgtgg tacgggcatt tagaaccagg gaatccacct 12720
tcattatatt tctcgatgtt gttagcactg gatactgcag caatgcttac atagttcagt 12780
tcgttaaatt ccttattaaa ctgtttgaaa tattcttgca aagaggcctc gccttcttga 12840
agcatacgac ggatacattc cttcagagct ttctgaactg ctttaggtgt acttgatttc 12900
tgagtttcca gacccatgat tttcaagtgt ggttcggcat aacgagtacc ttccatgtcc 12960
caaacgttca gtgcataacg tttcttgcct gtccagaatc cgccaagacc tttagaacca 13020
agtggaggac cagcgatagc ttctcggtcc atgaacatca agtgctgttt gttgttcata 13080
tactcgcaca tctcacggaa gcctgcatca atagccggtt ccatacgttc acgtgcaaat 13140
ttatctaaga agtcaaccca atggttagta tcacggaatt tatcttcgcc tactttattg 13200
atgattgcat ccgccttaac ataaatggag tcagtatcgc catagagcac gaacttctga 13260
ttttcagttt tacacacact attcagatat tcgttaacct tacgttcaat ccattggagg 13320
gccatttgac caaacaatgt gattgcagtt gcgttcctga ggtcgtagta gcggaaccat 13380
acgttaccaa gtgcaccata aagggagttg ataagcaact tacggttaat ctgagcagtg 13440
ttacctgcaa cttcagtgag ctcggctttc ttcaacattt ctcttaaaga aggcgctgac 13500
agtgctttaa tctgggcttt gatttcgtca gagaagtcaa aacgataatc gatatccagt 13560
gggctatcaa ctgagagatt aggattttcc aatgcttctt taattaactc accattacgt 13620
tgagctgcaa gcatgtaacc tttatgttct ttacgctgca agaatacctt ggtgatttct 13680
gtcggaatca caccttcacg gtctttataa tacatcatgc cgttaggaga gcaactgtag 13740
acatcgctag gacgctgagc agttccggca atatattcat gtatcggtgc gttagcgaat 13800
gtgcctgcga tggtctctgg gcttatattc acttgtcgaa tgatactcgg gtacagagat 13860
gtaaggtcga aactcattac atatttgtaa gcgttaggaa taggttcctt aacgaaagca 13920
ccaggataag gttggaccac gtgtgaacga gcttgtggaa tgaccttgcc ttgttcttta 13980
aggctattaa agataatagc atcccaagtc ttaattggac tgaacactga ctgaatctgc 14040
atcttagcat aataacccat gtccaaactc agaagaatga actggcgttt catatcaatc 14100
tgcactacac gatatacgtc gataatgtta taggaaatat atcgttggtg gttcgtctca 14160
cgtaacttgg agattggacc atcatatttc aacttaccta ctttcaattc atattcagaa 14220
acataatcca aagaataaga aggctggttg gtaaagctga attttttata caggtcgata 14280
taatccagaa cagagatacc gaacaatgta ataatttcac gagcaccgta catgttctcg 14340
ataactttaa cacgggtctt acgatgcggg cttaatcgct tagcagtatt ctcaccaaac 14400
agatttttca gacggttata aacgtatggt acgtcaaacg actcaacgtt ccatccagtc 14460
aaaatcacag gagttttctg ttgccagaaa ttcaaatact caagcatcat ttcttcttcg 14520
gaattaaacg gaagataaac gattttgtca atgatttctt gtggaacttc gtcaccacct 14580
tcttcttgga gtttctcagc gattttaatc gaccactctt caacagtacc ataaggcgaa 14640
actaaaaggt cgaatacata gaatttatcg tcaatcgagt cgtagtgggt aatggcatcg 14700
ataggatgtt tagcctgagc tggttcaggg aatccatcag gagatgttac ctcgatgtcg 14760
aagttagcaa tacgaatctt agaagaatca tatctgattt ctttacgata ggtatcagac 14820
aaataggcca atttatagtc gtccatacct agggcttcga ggcccatatc gtccatacgt 14880
ttcatccatt gggatgcatc acgcatagag tcgaattctt tcttaacaca acctttacca 14940
tagatatcaa tgtattttac ggcttgctct gggttagcat gcataaacat tgtaggcttg 15000
taaggaactt cacgactacg ttcgttacca tttttatcga tgtaacgttc gagaatatta 15060
tcaccgattt gttcgactgt caaatagaat tcttgcattt catttccttt atagacgagt 15120
gattgtcttt tgtttgttga tgaatcatta tactccaaaa agggaccgaa gtccctttgc 15180
ttaaatttct attgtaaaac gtttaatgga tggattgcca tattcgtctt tagttctaat 15240
catagcctgg aaaactcgtt gacctggatg tagtaactta tggaggtcct tttgaaattc 15300
tatttggagc tcttcggaaa ggtcaaaaac agtttgagtt ggggaaagtc cgtatacctc 15360
tttaaggcgt tcacacgttt caatttcaag aatcatatta attaccaatg gtgtacttgg 15420
acagtagttc ccagtcattt ttctgcttaa aggaaatgac acggaaatta ttagtgattt 15480
cgaacagctc agagtcgtct acgatatcaa tcagtcccca ctccttaaga agctgggcaa 15540
tcgaatcacg acgttggtag tcttcaccat cgatatcaac ttgacggcca tccatacgca 15600
acatctcttt aaagtggacg atataatata gcccttgttt ttgcagaatg tggcaggatt 15660
gatatagttt cttttcttta ttattagcga tacccatacg agttagggtc tctttcactt 15720
tcaagaagtc ttcaggttgt ttcagagtaa tttcaatcat tttaatttac cattccaatg 15780
ctttcttttt caagtctttt tgttctttaa catttttagt tacggatttc aggaactcgt 15840
ccgtaaccaa ccctttcatc ttcttaagca ccgccggaag atggccttta attttataag 15900
tctcgagata acgataagcg tcatcattat taattgaatg gtatttcatc aataaacgag 15960
taataaaaac cacactaact tcatcatcat gggccttagc ccatttacca aatctcttac 16020
ccttaggaac cgcatgtaaa agatagttga agtggctttg gtcatcaagt ttcagacagt 16080
taaccattgc agctggcata atgcaatcta catgctggct caaactattg tcgagccaaa 16140
attgattata gttttccgat tgagccaagt tacgttgttt cttaccatat gtgatatcgt 16200
tcataatggc aaacaattcg ttttcagcct tttctttaaa tgaatcggcc aaggcttgaa 16260
tagcagcatc gttacgctgt ttccaagcaa cttcatgttc gttcagttca acgtcatcat 16320
caaaaagact tatagccatt ggagctccag agcaagttgg atgaacagat aagtcatgtg 16380
aatttctggg ttagccgcaa taccgtggta ttggttattt tcaccgacaa tttcatacat 16440
tctaacaatg ctcggcccag gcaatttacc gtagagttcg ttagccagtg acataataaa 16500
gttggaatag tcattgacat ggcgtggagc taatgcacgg agttctttaa agtttttatc 16560
tttcagtgca gccactactt catcgatagg cgaattggta ttcattacaa tactcagaat 16620
gcctgtatcg attttaccac tggatgagta acggtccagt tggttaactg ttttacggaa 16680
gtcaggaaag ttttgtttaa ctaaagcagc aataacttta aggtcttcga cttcgatatt 16740
ttcgttttta cagattgcta cagcacgatg aatcatttct ttcatcatgg atgtttggtc 16800
tgccggagtg gcttcaccaa atttaataac acgacaacgg gattgaagtg gaccgataat 16860
accatcaata ttgtttgctg taataattac agaacagttt gaggaatagg cttctaagaa 16920
cgaacgaagg tgacgttgag cttcagcaac accagcacgg tcgaattcgt cgataacaat 16980
taccttacgc ttaccttcga tagatttgga agatgcaaaa cgagtaagtt cattacgaac 17040
gaaatcaata cggcagtcag aaccgttaac aaacagcatg tctgaatttg tatcagcaca 17100
caatgcttta gctacggtag ttttacctgt gcctggtgaa gaagagacta ggataatgtt 17160
agggattagg cccttattaa caatggcttg gagggtttct ttatcatgcg caggcagaat 17220
acactcagat aaagtacctg gacgatattt ctgttcgaac atgaattcat tattgtttac 17280
tgtaagcata ttaatttcct caggtttgtt tttacattat actccaaggg aggagattcc 17340
tccctatgct ttagaacgag tggcttgagc ctgcttccat agccaataca taagaagctt 17400
gtgaaccttc aaacttggcg gcgaaacgag catcctgacc ttcaccacga gcccatagca 17460
atacatggta atcagcaggc atcattttca tattagtttt gttgataatg aatttgaatt 17520
cagggccatc atggtctgca accactaagg aatacaatgg acgtgccagg tccttatcat 17580
caacttgctt gtagccattt attacaattt taccattgtc tacagtaata gcaaatgtat 17640
caatactcag accagaggac acacgcatca gctgctggta atcttcagct ttaaggtcaa 17700
aaataacttc agccaccggg aatggaatag ctttgcttgg gaatgcaatt gtacttgggt 17760
cggcaatagg ccacttaata gttgaacgtt ggtctttaat aattaaagtg gtttggtctt 17820
cacttaccga aacttcagca ctatcggata ccaatgatag aatacttaag aagccgttca 17880
aatcgtagat tgcggcttcg atatcaaagg tatcacttac agtagcttca ccataacttg 17940
cacctgttac tgaacgagtt agaatagtgt taccaggttt aagcatgata cctgggttaa 18000
taccggagaa gtttttcaga atgttaagag tttctttaga gaatttcata atgtttcctt 18060
atcaagtcaa aaattaatta agcaataacg atcatttgtt tacgaatgga ttcaggcaga 18120
gattcaatat actctggaat ctgggaagca acaatagcac cggcttcaag caactgttcg 18180
tcaaaatcta cgcaataatc atcttcgaga cgttcagaac catcacggtc gataaccagt 18240
ttagcacctg cggccagtga atcattatag tggcgacgca taatttctac ccacttatcg 18300
gatacgtcgt tatcaatgat accgtagagc atgaacttag tttcttgtgg aagagattgc 18360
aggcgacgtg cagagtcagt atcaatattc agtacccatg atttacggat acggttttgg 18420
ttatgtgggt tggaatcagt acgaatggtt ttaacttgga tatctttaac agtaatagcg 18480
ttagcaaaca taatattttc tctcatttgg ttggtagatg tattataaat caatatttta 18540
aagcacttaa cgtttaatca aagtattcat aaacgaacca ggctgggttt ctgttcgaca 18600
tgattctatc atactctgac ttaaaagcat ttcggagata atcttcagta acaagatgtt 18660
cgtctccaga gaagttgtta actaaaacat atctctttat ttcaggaacg gccaacaaat 18720
gctggcctgt tataaaatca ctcattccat caccgtgaat cgtccaactt tcttcatttg 18780
aagatgttgg ccataagctt gtgggtcatg gtctcggtga gagataatga acacgttcgt 18840
atcctcaagg ctattcaaga tggttgcaat ggtcttaacg ccttcagcgt cagtagcact 18900
gtcaaatacc tcatcaagaa ttaacgtgct gatattaaca cctgatacct tagaagcaat 18960
atcacgccat gtaaaaagta gtgcgatatc aatacgtgct ttctcaccct gtgaaaatga 19020
agcataacta aagtcttcac gtccacgtga tttaatcgtc tcattgaact cttcgtctag 19080
tgtaaagacg tagtcggctt ccataatctt caaataagaa tttatctgct tattaaagat 19140
aggaatgtat ttcttaataa tggaaccttt aatacctgtg tccttcaaca tttctgtcag 19200
aattccacga tgatattttt ccattaccaa ggacgatttg gtagagacga ttttatcaag 19260
ctctgcttga agcgcggcaa tctcttcagc attacttacg aactcagcag ctgcttggtc 19320
gattaatact ttaacttttt tagctttctc tacagcagta atggcttgtt gcttatgagt 19380
agctatctga gatttaatag ccagtgcttt attacgttgt tcggttactt ggtccttaat 19440
gagcttgagt tcttggtact gctcattaat cttatccaaa gatttttgaa gctcaaagtt 19500
cttatcctta attttagtaa ggatatttcc atgctcttcc aatccttgca tacacgtagg 19560
gcagtggccg cctgtttcgt ataatttcac aaccttagta aaggttgcca tatcattctt 19620
gattgcaaat cctttattgc tcaggtcact catagagttg ctagggtcat catcgactat 19680
gacattgagt aattcatcag tcagtttttc tatattgccc ttcgcagtcc tggcttcttt 19740
aacgagctca tcgtacattg tttgtagacg tgctgcattt tcaccggata atttacgctg 19800
acgttcttcg ttgtcattat aaattttaat ttgctgggta atagaatcct gtttaacgtc 19860
gattacttgg atttggctat tagtctcacg aatcaaagat ttgttcaact tgtccatatc 19920
cgctaataca gaaacctcta acaggtcttc cacaagcttt cggcgcgcag gggtcgacaa 19980
acccatgaaa ggggtatacc ctgctgtacc aagtacgaca atctgtttga aactggcata 20040
tgacattccg ataagctgtt caaattctgc ttggaagtct ttactgctgg cagattcatc 20100
aagacgttca ccgccacaag agatttcaaa aacgtttggt ttttgcccgc gtttgatgta 20160
gtattctttg ccatcatatt ccatccacag ttcgaccaaa aggtctttct tattacttga 20220
gttaattaat tgccctttct taacatcacg aaaaggctta ccgaacagag caaatgtaac 20280
ggcttcaagg aacgtagatt taccagcgcc atttttaccg gtgactaagg tcttttggac 20340
cttgtcaagt tggattgtaa taggttgctg gcctaccgac ataatatttt tatacgttac 20400
tttctttaac ttaaaagtct tcatcgttat aagcatcctt gatgcatgat tcagccatat 20460
gaattaatgt ttctggagta tcatctacca ttacattaaa gctaaattcc acagcccaat 20520
cagtagcaac ataaacttta ataagctcgt tggtatcacg agtgctcacg gcttcaaacc 20580
agaacttaat gatattcgtt tggttatcgt catcaataac gatgcagtcg tgttctagtt 20640
caagtcctga tttttgaatt catctaaagt catcgtgtaa cctcattata aagttgtgca 20700
gccatagtct taagggcttt aacatcgtct tcagtgtggc catcaggaag ggcattgata 20760
taatcataca tcatgtccaa gagggattta acttcatctt cctcttcaga atcatcgata 20820
tcaacactgt tatctacctt agacacgata cgtaaagaat ggacaacctt ttcaagctct 20880
gattcgaact tagtaagacc gtcatcaatt ttatcgacta taacacgaac tgcgatattt 20940
gtaaaatctt tgtaatcgat agtcgcattt ggataatgaa tcttacggtg ccaacaggtt 21000
tcattaatga cgaaatccat cttatgagtt tctgtatcga aaatccagaa gccgcgaggg 21060
tcgttttcat caccagcagt cagggtccat ggggtaccaa tatacttaac gtttgctgca 21120
tcagaaatag tatggaagtg cccagaccat acctgcttat acttcttaag gaaatcaggt 21180
tctaaaccat gggatttcat tcctttatag aaatagaaac catttaattc ccagtgacct 21240
atacagaaat ctgccgtggt atttttgata tggtccatga tatcggtcgt gttttcttca 21300
cacatccatg gaatcaaatc aatttcggtg ccatcaaagt taaccgtagt aggtttctca 21360
ataaccttga tatggtcata tttacccaga acttcagaag cagcgttcgg tgtcaaggta 21420
tttttgtagt gggcatcgtg gttgcctacg acagtataca tggtaatgcc gttggtttta 21480
agcaaatctg aaatatgtct agcaaattcc atgcacttat gagtaattgc tttacgaaca 21540
tcaaatatat caccgtactg aatccataca gtaatgccat ttgctttaga ataattgatg 21600
gcatctttga tgccggccaa ttggatgttt tgcacccaag ggtcgtcgtt cttcactcca 21660
aggtgccagt cacctgtgtt taatattttc ataagccaag cgccgttatt gcagtgcaaa 21720
ataaaattat tgaaatgaac ccgtcaggag tagaaaagaa tcctatccaa caggctcgtg 21780
tgaatgtgta gaatgccatg aataacacga catatcctaa aaatagttcc atatgttctc 21840
ctcagttggt tcattttatc atccgaatat aaagcaaaaa aggagcctaa gctcctttac 21900
caactaatac accatacaga ggttcgtgat tagacctgaa cttgataggc ttatatgtaa 21960
tagtaccttc attttctgct ttaatacgag cggcttcaaa tttaagcaac atctcatttt 22020
tgtcagattt aatcttatca aaatccatcg aattcgtcat tcatacaacc tcttaaactt 22080
tttcgtattc gtctttcatt agccacctgt ccatgttatc atcgttgcca ccatttctta 22140
agttggtgtg aatccaccca aaccttggct acaggctcaa tcttaaaaat accatcagaa 22200
tattggccca tcattttata ttcggtttcg gactgcttaa tacagatatt accgtatgag 22260
cgaagtctaa aggcggcccc aataagaagc cgtttaaagg gtttatttac tagggccatt 22320
gacgatttcc caaatttgtt tgcgggtaga ttcccacatc aattgaacaa gttcatcagt 22380
aacaggttga cggtaaatac cacgtaattt aattaaagcg tacttatatg cttcaaagtt 22440
gttttcaagt acagcgcctt gggcatggag atttaaacga cggatttcac gagcattctt 22500
cttaagaatc ttagccgctt gagaattagc ttctttaata ttatgctctt ctaaacgttg 22560
ctgggcttct tcaatttgct catcggtcaa ttgagaaatg tcacggcttt gcatattatt 22620
cctttggagt caattcaata gtgaagtaga aattagcgtt ctcaacatga taacgataat 22680
ctacgttatt gtcaggagaa gtgaattcaa tattcctgac gttaagtggg tcaatatcaa 22740
taggaaggcc tttaacatcc cgtaatatca atttaataaa ataagggagt gcttcgaagt 22800
cttccattcc atctaaaagt ggagtgatat taatctgatg ttccatataa aaaatccagt 22860
tcaccaactt taggttcggc actcttatca gaccctggtg ctttagttaa agaggtttca 22920
tactgtgtca ttttatcgta gatatcttgg ataaaggttt catctgcaat acctaccata 22980
tcgtcatcat tactgtcata gacattatgg acgaagtagc tatatttctt tgccatttct 23040
ttacgttctt ttttgatacg ctgaacgaag gcattaaaac aagccatagt gatatatgca 23100
tgcgggttgt cgtattttgt ttcgtcgaag ttgtgaagac ctttaatcga agcttcgatt 23160
ccatcagcta tcatttcctg ccgccaagat tgggtatatc ctgagaagtt gaaacgcttg 23220
ctgaggcctt ctgctataag cataatagcc aatcctatag tatcattttg tctaatgatt 23280
ttattagggt cggtattagc atataattcc tgcttccaac ttgtaatagc tttaagaagc 23340
tccttgttat ttacataatt attttttgtt aacttcacct gattcataag ccctcttaaa 23400
cctatcaact agtggtctaa aattatttat cgtatacgga taacccagtt cacagcattt 23460
gcgccagaat ttagaataac tagggcgtcc ttccttaatc caaagttcat ggaactcatc 23520
atataataca tatgttggat ttttagcaaa cttggaataa ttctctatag agtaatattc 23580
tttgttcttt ttacttttgg cctctctaac ttcaggattg gcattatatt ctttatggat 23640
tcgccgcatc atttctcgat gctcttcgtt ttcccaagac tttttaatag agttggaaac 23700
ccgctcttta tattcagggt cctgccagcg ttcggtaact tctttagact gttcttcaag 23760
tctttccggt gtcggaggag cataaccacc tataccacca ggtttcatat tgacacagtt 23820
agttatttcg gacatagcat tttctaccaa aagctcttca aattcaaaag caagctcact 23880
tgtctcaaaa taacataagg cctctatatt aaaagagcat ttccctgagg ccttagcatc 23940
ttctacgaat ttgccactac cgacataccc gtcatctata aatccggtgt gtttaccgaa 24000
atagtaataa gtatcatttt cggattttat agtggtcata taacaatagt gcataacgat 24060
taatctttaa tttaaataat gaatctatta tataccaatt ggcttaaagc atcaacggag 24120
taagcaataa gcctgaaata ctgtttcaag gatttttttg aactcttcaa aggaaggggc 24180
tccttcaaac ccttggcttt gaatgtaaag acagaattgt tggtaaagga ccaaatattc 24240
tgattggttg tatttggaaa tatgagactt ccacacttcg gaagtctctc cacaaacaaa 24300
ctcaacattc atatagctat ctattaagaa aatccctagt ccttcgtagg cgagggtggt 24360
ggatacgggt ttcattgtag gaatcgagct ccttccaatg cgtcatccag attatcaaac 24420
tcgtccacgt aatcaacacc gccaacttcg tccttcgcat acaaccaata ctggtggaat 24480
tcatattcaa taataaagtg ggcaccttca atctggagag ccccatcacc gttaaattga 24540
actgcataac ctgtaaagcg gacatcattc aagagttctt ctttcatagc aatcatttcc 24600
aagtttttat cgtaattaga gagttttatt ttaatcattt aaataatcct caaattcatt 24660
taatgtcatg ccttcgtccc aagctatttt tgggtcaggc attttcatat aagtggtctt 24720
agagcttata ggaaatatcc tgaaatcacg atgacttcca cttagcatct tagccgcttt 24780
tataatagtt tcaatattat tcatcatggg cgtacgttgg aacccggcta aagctttaag 24840
gactattata accgatacat cttcaggcaa attactcatt tagccgcctt aacaatttta 24900
aggtcaacga attttttctt acgttggttt ttcatacgac ggatagtttt atccgagatt 24960
tcaccagggg cccaagcttt agattcaaca ccaaaggcag cgacatcgaa ttcatcaagg 25020
atatattgaa ccaggatttc acgaataccg ttcttaccaa ttttctggtc tttagagtgc 25080
atgattggta atagttcagc aacccattgg tcaagaacct gaggagttac aaaacctgtt 25140
ttcatcagtt cgtttacttt atcgaaagcg aaagagttca gtacgttttt aatagcttgt 25200
gacataataa tttcctcagt tttaaagtta taatccgtgg gaccattata ctctggtccc 25260
aagagtttgt aaactatttt tgtgctttag cgcctttcca gccttcatac atcattgctg 25320
cggaaattaa caaagcaccc gagcaacttg aatatttgtg attccaaaac cagttcagaa 25380
atacttcgtc atcaatacct tgagctatca tattttcaaa gaactgacga cgagcttcag 25440
caattcgctg tgataattta gattcaggat tcatttaaat tttccaattg ccattttcat 25500
caatgaattt aacccagtca tttaccgacc acttggttgt atcgcctttt ggagcaacat 25560
ttaaagtata tagcccctgc ttaaaaagca ttcgtttgat attcatattt tcctcagctg 25620
taacgataac actcgtttga tttacgtttt gcaactcgat gagaagtatt gtaatcaggc 25680
tcatcatcgt tgtaaacatc ttttttcagc tttctcactt ctttacgaag ctggcgattc 25740
atttcattct taacttcgga atcaacgcct ctcatacgtt tccacttgtc agaacggaag 25800
atattttctt caaccagttc ctggcttaca ccgtccggtg ctttgcggcg acccgaataa 25860
taaaaatctt ttacagacaa ttctttacga cggatagttt tacccatagt tacctcagca 25920
gtttgcatca ataagatttt taatgtaatt aacgtctgca atactcagat cgagtttaat 25980
agctttcaga cgttcatcca gagtaaggaa agttactcgc ttccaattct taacagggca 26040
gcaataagtc ttaggaccgt tagcgatttc aatattttta tctgtgatgg tgataaaaat 26100
caagcgtaca taatcgagat tcagggtgat gacatttctc tttgcatgta ttttcaggct 26160
catgagttaa tttcctttgc tactgaacaa aatacagaac ggtcgcacac cattaacgga 26220
gcatcagggt gagtcaaagg ttgataccat acatcgagat ttgttacctt tgttacttga 26280
acagggtagc catttactga ataatactgg tcgactttaa tttctttatc ttggatagtc 26340
ataatgttct cctcatgtgt tgataggata gactataaca cgtgaggaga ggaagtaaac 26400
actaatcttc aattaaatct cggtcatagc caagttcaat caaaagtgac ttaaaggcag 26460
gaatattttc tattttctta ttatcgacaa agatgacagg atagcgtatc gctaagctct 26520
tgaagcctgc gcgtttggcc aatgatacta taagaggctt gtcatatacc gcgccagacg 26580
gcgtctggtt aatcacagga tagaaagtat gtgggataga aagggaattt aggagcgata 26640
gaactgcaat gcaccctgga cagcgcatga ctgcctcagg gataccgtag atttcgattt 26700
tagttaactt ttggtccaca ggaaataact ccttggtagt cccaggtttt tagaacttcg 26760
tcctcactag ttccatacgg gacgtaaatc tgaataagaa atccggtatc gtcgaagctg 26820
aaataaaccg tcggtttgat tccgtgaatc tctgatagag catagatgtc cttgaggtct 26880
tcttccttat cgacaaagaa ttccgggttc aggtcacagt catggaagta ccaatcatca 26940
ccgaatttgt cccatgcggt ccaattcaaa gctacatatt cttcaaaacg tttcattctt 27000
tcaccttcat cattttagaa ataacaccat ggacagactg gattcgtttt tcgaactcgg 27060
acccttcaag acctttttca gtactcaggg caccgataat aacaaacagt aatccaaacg 27120
ggatgaccag gattaaaagg cacacgataa acagggcaaa tgtaatattg gccaggatat 27180
cagaaacagc attacgaaat ttgttcatta aagaacccac atgttagtta caacaaataa 27240
ccattgagca ggatactcaa cacccataat acgcaccgca tcgttcagag attcgattaa 27300
agcataaaat gtgtagccat aaaaattaat catttaagcg atttcctcag ttgttttttg 27360
aatgaatcca ccatttgttt cttagtggca gattcattat aagtcattcc gtgtgaaagc 27420
atttcagcaa tcatttcttc cttacccaac ctgctgaact ctttggtttt atcaggaacg 27480
aaattaggat gaatattgtt ttcagtataa tcagctttca gatagaccag caaattctct 27540
aaccattcga ggtagtcaac gttttgacct ttaagaccag aacggttgaa cttatgcttc 27600
atttgtcctt ctgcagcatt gcacaggtta catagtaaac cacgaacctt accggctttt 27660
ggcccgttta actcgtggtc gtggtcaagg tggttacttt gaacatcagg gtttaattca 27720
cgtttacaaa tcaaacactt accatgttgt gcatcataaa gtttttgttt ttcttctttg 27780
tataatttgc cggtcaacaa cataataaac ccttaccatt attagataag ggtatttatt 27840
aatatcctaa tagtttagca gtgcaactta gcactaacaa caatccgaat aaaacaactc 27900
ctacccaaaa taccgtaata agagcctcca tatcagaccc catagaatga acgatgcaaa 27960
cgtttgaatt gacgaatcat ctttttagta ggacgggtgt ataatcctac acaggtggcc 28020
ataaactggt cagttggact tcctttgata agaagtttcc agaccttacc gccatttaat 28080
ttttcggtat agactaatac agttttcatg cgacctcaaa ttcattatca tcgttagtcc 28140
aaaaacacca gaatgaagct ttagtatctt caaacatttc tttagtgtat tcgtatacct 28200
taccattgaa ttcgatagca gttacgccga tgatttcagg gtcgccccat ggagaaatct 28260
ccaccttcaa gattttaact tcagcgcctt cacaaagctc acctgactca aaaccacgat 28320
taccatttaa ttcaggccag tcaacataat ggtcgacatc ttcttcagta atacgaacag 28380
ttttaccttc aaattcaaat aaattcatca gaaggcctca tcggaaaagc gaagttgagc 28440
ttcaagccaa tgaatataat cggctgcagc tttaatcaaa tcggattcta agtcaggtaa 28500
agaacccaaa tccgacaatt cgtaaagcga atgttcaatc agacggcctt tatgacggcc 28560
aacttcaatt ttggtactca tatccaaact ccatatcgat gaaatcattg tttgaaggtt 28620
cattatactc tatttcggaa tcgttgtaaa ccggttcctc tggctcggta gttttccacc 28680
gagcgacata ccatggctta acggtcacac caccaactac ttacttcaaa atcaggttca 28740
ccgtgttccc agtaccaagg gccgactgga tgccaatcgc catgttcatc ttcttcaaat 28800
tcttcagatt caagcccaac gtattgccat tggacttcat aagcggtgcc acctattaca 28860
acggtgttct cgccatatgg gtgagctaca gcaaagtcta taccttctgc tttagccaac 28920
caaaccatat attcgtatag tttatattcc aggtcatctt cggtgccatc acctagaaaa 28980
atggtttgtt cgtttaattc aatcataatt ccaccataaa ttcaaatagc tggtcacgta 29040
cacaagtatc agtccagccc cattcgttgg cttcttcttt taaccaatcc gggagatttg 29100
ccaatacggt ttctttacta ggcgcaggag tatcaaactc gcttgtaaac tctcttgcgc 29160
aggttccata agctatatca aattcaatca tttgaagttc cagaatgaag caccaaccag 29220
aaataaaggc caacaaatca tagacgtcag ccaccaacaa aagtcacctg caccgaaatc 29280
atctaattta gctagggtct tagcataacc aataccgatg ataagataca aaatacccaa 29340
caataattca atcatttgaa atatgctcgc aattggtcaa agccaccaat agaagttccg 29400
tccggagcaa atacctgagg catagtcaaa cccacctgag attcgcgacc aagcgcagtc 29460
aagagttcag caatcttctc atcatcaaat acgccttttt ccggcatcac gttaatgaat 29520
tcgtaaggtt gtttcttaac atcaagcaga cgtttggcat tatcacagaa aacacaacgg 29580
tgaatatttg aatcgtaacc ataaacttta aacattttaa attcctaata tttgtttgaa 29640
tgcttcagaa cggtcgagtt ctgttccata tttttccatg tgctcatatt ttaaattata 29700
cacatcagat agtatattat tatacgagcg agttaaagca gattttaaaa ctgaataact 29760
gtctgggaat ttaccatgct ctttataata agctagggta agttcgcgga ctgccttatc 29820
ggcagcctct acatattctt tacgctttgc cattttcgtc tcgctcaaat ttgtgtttac 29880
aatggcggca tttgtaacga agattactag tctgccaatg gaccaattgg acctgttctg 29940
taccgcactc aggacagtta ggaacatcct tagaagcttg ttctcgtcgt gcgaccatag 30000
ccattacagc atcccaatta acggcatcac cataatcatc acaaccatga attttaccaa 30060
ccaattcaac ttcaacatcc gcggctttaa taaatttcaa taaaccggta ttagatgctg 30120
aagcaatatc ttcagctaaa cgttgtttca tttcagcagc tccagagctt gttcaagacg 30180
gtctaaacga ttggtagact cttcccaaag tttcttggcg gcggtatatt ggccggtcag 30240
ttttttgtta atagcaaggg catctttata cgctttttct aaggccacga tttccggtaa 30300
cttggattta gtaattggtg taggggccat gatagggctg ttcaagtcgt taatcaaatc 30360
ttctaatgta gcgggctctt tatcagtgtt cacaatttcc tcacattttt cttggtaaat 30420
ttcagcgtca gtttttggaa cggtacattt gatttcacgg actgttacta agacttcata 30480
tcctttccat cctaagtggt gtttaacttc ttgggtctca tatttctcta cggtatccat 30540
cagagctaaa gcctgttcga tagtattcaa ggtatcgtaa gcaatatctt gatactttac 30600
aacttccaca tcatctttag gtttcctatt aggtgaccaa ataacagaaa taatagcttt 30660
tcctttataa ctatttgttt taatcatgca attagccatc gggtgaatag tacgacaatc 30720
accggaaact atagttttag aggccgcttt gagaattaat gcagagttag ctttgaattc 30780
ggtaacccaa cgttgtggaa ataaactact agggtccata cctttaattt tgatataact 30840
ttttatggta tcaccaaacc atttgtagct aacagcatgg ctagaacccg gatgtttctc 30900
tttgccaaac tctgaaagga tgtccttatt gaccagtcgc gaaagcagtc gagaaccttt 30960
aaatgtttta atgatatcat gaatgcacaa acggcctgca atcttttcga tttcagcttt 31020
gaaacagcgc gataatgcat catcaatttg gtcgacccat ttattgatat tagaaactat 31080
taccacatat ggggttaatg gaggggtgtt ggcagtgata tacgtagtaa aggcattgat 31140
gtattcagta cgagtcatga tattctcctc aagttgatag aaagattata ctccatccat 31200
ccttggatgt aaacattatt ttagagctaa tactgcggcg cggagcttgt cacgctggag 31260
ttccatgttc ttgatgcgaa tcaatacgtc ttgaatactc tttttctcat cttcgatctg 31320
accatttaaa cggtggattg attcctggag gtggtcctca tgatacttct cgataggttt 31380
catcgtaggg ttagtaacca ccatagaatt ctcaggcttg attttccact gatactgttt 31440
ggaattgaat ggactaggca cagccgtggt tttgaatttg tcataggctg catactggcc 31500
tacgctgtca catgatactg cagagatacg tcgttccatt tccggttcct tttgttggga 31560
ttgataaggg gcataagaca aaagatattc acgagttagt ttaacattaa aatacactgc 31620
atctgctcgc ccggaacaat cagcatattc atctgttgta accttatatg attctacggc 31680
cttaatacga gtcattgctt ctctgaataa ggtttcaaat gctccacgaa gggccttatt 31740
accttttgag gtaggacgga aacgaacttg aataccgtca gccaaaatat taatgactag 31800
gttacgagcc gtaaaattaa tattcttgat attgatatga accgtagaaa tacgtcctgc 31860
ggtagccaag aggtctttga tattagctcg taatgttgca ccaaacaggt gggccgggca 31920
acggcaataa tcgttcaaag aactaatata agtcccttta cgtcctacac cataagtata 31980
attaccatta caaatatggc cgaagtcggc cagccgatcg atagcgatac gacgtgtggt 32040
atcaaaatca tatcgggaat attctttacg tgttttaatg ttcatatcaa agtccaaata 32100
atttttcata gaatttagcc ataggccagg ttataataaa aactatccca aacatagcaa 32160
gaactggcca gataaaggtg gcaaacgctg cttcaccgcc tgagttaatt tccatatgat 32220
tacgaccaat aaggacagta atgaatccta tcacaaggta tccaaaaata aaactgataa 32280
ttatagccat attaatcctt aagaagattt aggatatcga tatatttttg acgttcagcc 32340
ttagctttag cattcagacc agagagtcgg aaaatctcat catcttgttg ttggattgta 32400
acattcaagc aagtaagcaa attgctaaaa tactcgattt gagattgatg cttctcattg 32460
ctgcgcactg gcacaggttc cggtttagga gctcgttccg aatgactctt aacttcatta 32520
cccggcttaa caagtttaat acgccggcct gtactggtat taacattatc gaaggtaaga 32580
ataccgctac gttcgagttc ggacaaagcc agtcgaagat ggaatttcca attgtcatat 32640
tgacaaccac taaaagttga agtaagatac tcgttttcgt tacccggttg gttgacaata 32700
ttaaagataa tccaatcgcc tgaaccatta gtcttaaatg gcatttgctt atctttacct 32760
aaagctagac gagcacccag tgctagtaaa cgacgttggt tagtacgaag gtctttaaca 32820
acttcatcaa atgacatcgc cgggattaaa cgaccataga ggtcatagcc tttgttataa 32880
tttctaagaa taattctggc gttagcacga gtcaacatac cggccctgtg aagagatttc 32940
atgactcggt cttctaacgt aaacaaacct ttagtcttgt caaagatttt agtgaattca 33000
tctacagaaa tacaaacttc aaacttttcc cacatcatgg ccaaaacctt ttcaaccact 33060
tctttattca gtggaatacg accaaattta ataacttttt taacttcaga acgaatttga 33120
ttaattgcct gtgacataat aatttcctca gtaagtaatt aagaacctag aaccattata 33180
ccatccttgg tataaagcgt ttatgcgaga accgtcttta aacgctcttc aaatttctga 33240
agcagagctt ggcgttcagc tcgttgtgat ttgtactgct cgatacgacc tgaagtgagg 33300
gcgtactgtt cgtttactga ttcccgcatg aattcaggaa tctctttaca agctttgatt 33360
tcgtcaaact tatcaataac agcttgttgt tcagcaatca gattatcgaa ataagcgata 33420
tcagatttaa cgtttgccag gtcagattcg gtaggcatta aacgtttgtt acgttcagct 33480
tgataagctt gattgttttc acgactccag tgaagagtac gttttttgtt agtgttttta 33540
tagagctcta caataccaac tgaatcgatg actgcaatcc aattccaacg gcttttgtaa 33600
atctctcctc cagatacggt aatctcatta ccacaagcaa cgtcgttaaa gaacttgctt 33660
tgtttttcag atttgaaatt accgttgttg aaattaataa gtgaaaaaat atctttagcg 33720
ttcatgataa cctccagtag ttgataggtc tatagtatca tttctactgg agatgtaaac 33780
aactaataga aacttttttc acctgcttgt ccactaaacc acgctgattg ggtgttctct 33840
ttccgttgat gttcaatacg aatgcgatat tcattcctga tggcgcagag ttcacctcgg 33900
aagtcgcctg tcaactttac ctgcttgtgg tctagattta ttaaggcctg ggtcttcgcg 33960
gccaggagca gtctcttgta gtctccttct tcacaatcag ttttataaac tctattagta 34020
tatccatcga taagttcttt atcatagtcc tcgacagact gtttcatggc tttggaaaaa 34080
gtctgacctg cgttataaag attgtaaata aattgttcga acataatttc acctttattt 34140
cagaagtgta acttcagcga tttcgctcca gtcattttta tcggtggcaa tgaagtccgc 34200
cagataaaga gctgtacgta atgatacgtt acgaagacga gatacattag ccttcatcca 34260
ggacagtgct tgataagtct cggcatcagt cagaccacgg ttttgcatca tatcagtgga 34320
caggataacg tcttcaacac ggaccataat ctcttcgttc gagtgaactc cgaggtctaa 34380
gtaaactgaa cgcgatacta aagcctggag gtgtggagca agtttagttc cacgctctaa 34440
ttcacggtcg atatcaacgt tggtgatgaa cacgatggtg ccttcgtatt cgaattcttt 34500
atcgatgttt ttatcatcga ggtaagaact tgaagtgctc cagcacacct tacgtttttc 34560
acctgtatcc aatgctgctt ttaacaggtt caggatatcc atatcagaga atacatcaac 34620
atcatcaata agaagaacac tattagggcc gcggttattc caaagctgct cgtaaagacc 34680
gattccacta atctttccgt tgattgattt atattcgata gtttcatttt cgtgggcatt 34740
ttgtaatgct ttatccaaag aatacgtttt accaatacct gcggcaccag agatgataag 34800
ggaacgaatt ttaccatcga tgattccgtt ggtcatcatg ttcattactt taaaacgttt 34860
gttaatgcga tgtttcattt cttcagcgga ttcagtaaca actgcaggag cttcagcacc 34920
ttccatttca acgtcacatt tgaacaccca tacaccacgt tcaacaccat caatctgtac 34980
gaataccttg ccgtcaccga ggtgagcttc tgattcatga attttattag ggaaccaggt 35040
tttacctgaa ctcatgaacg taccagagat tacattaccg cgatagatac ctttgttgat 35100
tttgatagtt aacattatat tctccatttc actcagtaga tttgataggt ccataataac 35160
atgctctacg agagtgtaaa ctcttttttg cactaaaccc aaaaaaggcc cgaaggcctt 35220
tatcatttat aatacgagtt atggttttct aggtaaacct gctcaacgaa cttgtcccag 35280
aacttcatgt ctaccttctc aggcataccg ttcttagcgg cccagatagc attagtttcg 35340
acttcatcaa cgatagcttc aagttcggcc tgtacatctt taaaagcatg aagcccttgt 35400
ttgatttcaa ggataaacgg cgctgtacgt aaaggatatt gaaggtcacc agtttgatag 35460
atttccttca actgataacc agcacgataa gcatggctca gagctttcca gtcaatacct 35520
tcgttagctt cagccttacg agcacgttca ccatattcgg catcaagctt attcagagat 35580
tgcttgagct ctattaatga caaggtggtt tggtacttac gtcccaacac agtatagaac 35640
gtttgcgggc ctgttttctc atggttatga aatacccatt cacagaattc gttttcaggg 35700
agtcgatgtt tgatatcttc taccttagta cgacgttgtt tagtagaacc atcttcttgg 35760
taatcaatcc actgttcagg aatctggtta acgatagcca gtacaccacg caaagcagcc 35820
agacgagaac ccttaacacc atatttagaa gcttgcttac ggacgtaccc caaataggct 35880
ttcatgttag tcgtatagaa gcgtgaacga ttgtcttgaa taaatttcca tacatcaggt 35940
aaatcagatt taaccaccag ttcaggtgga gtgtggagca tatccagagc aacggtttcg 36000
ccatcagcag ccagtttaaa gaaatatttc aggctataaa gctcatggtc aacatcatct 36060
ttagtgtttt tggaagcagt gttattcgtg ttcaggttgg tatggttcat agccgtacct 36120
aacagaatat cacgcggatg tggaacaaag atttctttaa aatcgacatc agattccgga 36180
gtacttgttc cgtaaaggtg gctaccgaag tagcctttca taacagttct cattctttgc 36240
cctcgaagtg gattacagga cacatcttag atttacgagc tttaatgtat tgaataacga 36300
tgttttcttt aatttccttt ccttcgcgtt gggctttaat acgttcccat tccttttctt 36360
ctctacgcat atcataccat gagtgtaaat tcatcgcacc gaacgccaaa ccaatggata 36420
gtgcaataat gagagctatt gcaatcaacc ctaaaacaaa ccctagactc aacagaacag 36480
gggtacttaa tacaaagaaa tgctctaata caccagcgcc tgcaacagtt aatccaaaaa 36540
gcgtactacc agcaacaaca gcacaagcaa aacaagccca aaccattttc cagaaataag 36600
cacacaaaga gtgtggtcga gaatgacggt cataaaaacg atcgtgaagt ttagcgtgcc 36660
aagagtttgt attgataatc ataatatttt ccttaagagt tcatagttgg gataacagag 36720
ttcagataag agactaaaac ttttagttcg tctttagtaa ataccacttc actttcacca 36780
tcgtgtcttt gggtcaagga tagcaaatca cgaccctgat attgatacac ggttaattca 36840
gtatcgtaat ccagttcttc ttcgtcgcct tcaaaggttt cactagagcg aattacagca 36900
tcttgaccag ggactttcca ttcaacttcc ggcttgcatt cttcctggaa cagtttaaaa 36960
atacatttaa agaagttatc agaatcactg atgcttagac attccccgtc tgtttccaaa 37020
ttaaacccgt tgtcatggtt ataaatctgg gcccacatat catcgttaat atcaaataca 37080
cctctaaaac taccattaag atattggtgt ttgtccaaaa cctttaaatt ataaagcggc 37140
ttgatatctt ggatagtcag tacgatttta tcgtcttctt gtgaaagcac aattgcatta 37200
tcaactactt cagcagtcag gtcaccaaac agcccggatg tttcaataat cattttccgt 37260
tcctcatttc acattttgtt taataaaatt taacaactct ttaagagctt catcttcttc 37320
tttagaaagc ctgctgcatt cactagctgg gtaatcattg caaaacgcag tttcaaatct 37380
agcaactgta cctgcatagg cctcgataag ctcttcaagc tttaaatgct tttcttcggt 37440
tttcataaat caccggttat gttttaaaat actataaagc tcttcaactt ggcttgcatc 37500
cagataaatg acctcgtcat cttgttccag aacaatccca cctttaatga gattccattc 37560
caccacttca acagtcatat catcaccgga accggctaat gtttctggtt ctaaaacgat 37620
aataccgtct tcagaattac cactcgggtc atataacatt acagtttcct cgctaactgt 37680
gaaaagaata aaccaattaa aacaggccct acagccattg ttaaccaagc ccagggttct 37740
aagtaataaa tcatctcatg ctcctgtgcc aatagccatt atgctttcaa ctcattcaga 37800
taagcgacta atttttcttt agaaccattt aaatcacgct tacactgctc tattccagaa 37860
tatgaatagc cttcacaata ttcaacagcc aggtcattgg atgcgttttc aatgtgccgg 37920
gcgagtttaa ggatttgttc aatctgttca gtagttaaca tattatcacc agtatttgtt 37980
gatggtagaa attaattctt gggcttgggt agttttcagt ttacatccac aaccctttaa 38040
tgtgtcttta aggagccacg gttccttgag ctcgtccttt tctaggcgaa ttctgtatcc 38100
tcgataatcg gcaaagatac ttcggtcgtc gaatatctta atctcaagga tacggtcatt 38160
gatttcgtat tctaatgaaa ccgtagtact tgtaagtttc atactgttct cctcattagt 38220
tgataggtct atagtatcat gttcctagag gatgtaaaca cctaaacgaa aaaaggtccc 38280
accgaagtga gacctttgat tattctagcg tcagcaaata cttagtctgg taaaagacac 38340
cagtgatatc gtccaaagtc gactggaggg ccttaggaag ggtgtcatag attttatcag 38400
atgctttaag aagctcgtca agaaaatcta ccgggtcctt aggcaagtct gaagcagacg 38460
gtaatgatgc tttatattct ttgccactga atccaagata ttgctcacta aattggtcca 38520
gaggtccttg aacttctaca taatagaagt catacgcttt gtgtcttgca tagcttttgg 38580
tttctaaatg ggctgactta aaataggcta aagaaaccag tagccaacca atataagaat 38640
ccacttcaga ccctcgaccg ggtacgaaat cattgaactt catcttccac cttcattagt 38700
tttacataac gctctccgat ggcacgacct tcaattgagc acgcttctat agtccgacaa 38760
cttgaaatct tccaggaagc cgtaacatag gcccaatagt cttcggaggc ctttacgctg 38820
ggtctactca tttgcgcata aacaggcatc gcactactag caaatgcatc catcaattta 38880
tcattggtat catttgctag tgaaactgta gggcttaaac atcccgccat aaggatacaa 38940
gccgctgtac ggaaaatatc catacaaaag tcctttgttg ttttatacta tttgcctttc 39000
ggccttaacc gatagcgatt accaaaagct aaagctctac ggttagtatt attatttata 39060
gctttttaag cttacgacaa taagaataga acacgtcgtt aaaattatat tcaacccaat 39120
tcctctgtat aggcgaggta atggaaagca tataatgcgc tttaattaaa tccatcccat 39180
ttttattagg acattcttta ttattagcat tatacgtcgc tgctacaacc tctatctctc 39240
ttttgtaagc cacatcatcc atgataggcg aaagaacaat ataagaaata gccacagcga 39300
acgctagaat taaaatcttt gaatttaggt ccatagtacc ctcaactcgt tatttctatc 39360
cagtgcttcc tgcacaatga cacgtaagaa tcgttgccac ctatagaaac ttgggctccg 39420
tccttaattg cgataccatc ttggatacga gccgtcatag tagctttacg gccgcaatgg 39480
cacacacctt tgtactcaac gagtttatct gctgtagcga gtaattcagc agagccagga 39540
aacagtttac cctgaaaatc agttcttagt ccatagcaca taaccggaac attataattg 39600
tctactatct ttgccagttg ttttatctgt atcggttcta agaactgtgc ttcatccaca 39660
aatacacagt ggatatcttt ttgagattca gcccaacgat agaactcgta taggtccata 39720
tccggagtca ctgcattagc ctcttggcta atccctatac gagacgaaat gctatggctt 39780
gattctctat tgtctatcgc aggctttaaa aggagtacgc ccataccgcg ttctttgtag 39840
ttatgagcgg ctgttagcaa tgaagcagtc ttcccggaat tcattgccgc atagtgaaaa 39900
taaagttgag ccatattacc ttcttaaaga ctatttacat aagcaattaa ttcattttct 39960
ttctcatcaa accgactggc gaattcttcc tggtgttcgg catctatagg gccatattca 40020
tcataaaaag aatttgcttc tgcatgctca tctagaagtt catggataag ctcaaacaat 40080
ttatctttct gttctttact cagactcata accattgtac ctttaagcaa tattcttcta 40140
cgtgctgttt acgtttattt ttatctataa aagtatattc aacatattcg ccaatatacc 40200
atttatcagt gttgtgttga ctttttatag ggcatttagt tactcgggtt tcggtccagt 40260
gtcgaataat ttccgctttg tttttagggt caaacggatg cgggtaatgg gctttcataa 40320
tctaccacca ctaaattaat atcaggagta aacaaattaa tcaattggta aaccttgtcc 40380
caatcaccac cagcaatacc acaaccaatg cgaggaatat aaattcttgg tttaaacaaa 40440
agaccttttg cttgttgatt taattctatc atacagttta ctaaagcacc ataatcaaga 40500
ttagggcctg gttcgtattg ggtatataaa ttatagcaaa tttggccatt attacctgta 40560
gcttgagtaa acgtgccaag ttttgccaaa ttgcctaaat aagtagtttt atcgatagcg 40620
agaataggtg gataagcctt agccaattgt ccggctacac ctgaacccat tgtatggaaa 40680
cagttgcacc cgtgagcaac attattacct tgaagaaaca gggcgacgat atcgccctta 40740
atataatcaa taatcattta gagtttaatc ctcggttgta agagtcaacg agtctgtcta 40800
ccatagacgc gcacatttct ttgtactttt tatcagatgg aatacattca gtaacgttta 40860
gacgttgctc gtatctttta gaaagagttt tctctttcat tcggcgatgc tctacgtcat 40920
tctggccatc tttaaaagca gctgtgattt ttgaactgaa ttcgataatg cattcagtat 40980
tactcggatg acaataatct tttgctgtac gggtagcata ctcgacaatt gaattattac 41040
tatcatcaac ttgtgacgct aatactcccg gagcaatcaa cataagcgct atagtcatct 41100
gcttaatcat ttaatacacc gcctcaaaca tctttttaga ttttaggtaa ttggcctttt 41160
ctagaacttc agaagcatat ttactgcctg ctttgacgtt ccagcccgca ttataagaag 41220
caatcgcttt tctcaggtca cctttgtgaa catcaatcca ataagacagt tcaatgtagg 41280
cccaagaggc actgttctgt cgtttttgga ccatacggat tatttcttta tcagacatct 41340
tccaacctac ctgttgaaca cgacttctta acgtaggcaa gtaattttgg aacatgccat 41400
aagcatggtg cttatcttta tttaaacctt gattaattcc ggcggatgat tcctgccata 41460
gtaatccggc cataatatat cctaatcctt tttgattagg gttttctttg aactttcccg 41520
acttttggta ttgttcaccg aaagcatacg cataatgtaa attatcgagt tgttcattac 41580
tgaaagtagg ctctacgcta tgggcagaca tactaactgt caatagtaaa gtggctaata 41640
cttttttcat gagacctcat tattaaagat agattacttt cgtgctggtt ttaccttcta 41700
aacgtttaga gttaacaaat gccatacgac atttaaggga atatccttta tcaggatgtt 41760
tacggtctac agtcatacct agccataagg ttttatcggt aatttcgaga cgcaatgggc 41820
gatacacttt accagggaca atttcggatt ctacatcagg cagaggttcc tggattaaga 41880
attcatggat ttctttaaca tggttatgga gttgcttgaa taaagcaaaa acgtattttt 41940
cgtcgatttc acgttggata gcacggtcca acaaatgatt agagtactta ataaagaagg 42000
ctgggactcc gctcttaatg gcggcttttt tgatggacgc attcagttca cggaattcgg 42060
tttcgaactg acgacgtaat ttgttgcggc ggatgaatac ttctgaatta atttctgaca 42120
ttttgtaatc tcctgtagtt gataggttta tagtatcacg tctacaggag atgtaaacag 42180
ctttattctt ggaatggggt aagttttcca acagctgaac aaatttctac cagtacaggg 42240
taaaactctt tcacttgttc aaggcgttgg gctgcatact gtacttcacc ttcttcgaga 42300
caagccattt ggtcgtcaag caagtatttg tggtagccag tacaggcttc accaatgata 42360
cgctggaaat cttgtaaact ttcaattttc atcagtattt ttcctcgggt tggaaaacgg 42420
aacgacacgc ccacatgctt gcttctttca gacggtcaat tgcattacga atctgggtga 42480
tgcgttcatg agcctggtcc agttcttgtt cagaaacctc ttcggtatct aagttcatat 42540
aatgagtaac atgttcttct tccagagctt taaacattaa cccaagacga acttctgcat 42600
ctttaatcgc gttcacttta ccgattttat cgtcggtatg cggtttataa ccctttatat 42660
cttcaatcat ttcacttcct cgccagttgc gatatcatat tctactaaac gaaggccatc 42720
atatccacca cgaacagaga tatatgtgct cggataaaca atttctttac cgttccattg 42780
cccaccatcc caacattcca taaagccttg ttcgccctgt tcgtggaacc agtcaacaaa 42840
catcttcaga gcttcatcag agccttcaat tgtcaattta gacatatttc ttccagtcag 42900
aaatcatatg aatctcttgg tcataagtca agagactacg agttataata cccttacaag 42960
gccctgagat gaactcgaga gtgaagtaag gaacctgttt cattaatcgg atgcttgggg 43020
catgacatct aaaacgagag cccttaaagg gccctgtcat gaatacatat tccaatgggt 43080
agaaataagc atattcgaaa tttgcagtaa ggtcctctct tcgaacctta cgtgagaaat 43140
aacagaactc aaaaagttct tcatcagtca tcattgcatt cctatcacaa agaacagagg 43200
acgcgcagtt tgattggttt cgacacatga tgcatgacag caatgttgca ccacctttat 43260
atgggcatca taaatcttat ccatattagg tgttttaaca ggctcatcaa ttatatacag 43320
aacccgtgaa agtgataatc cacggaattt gcatgcagtg ttaccaataa aactacgaac 43380
agaatcagtg tacaaacggt acttaatact ttctgtatgg ctattaaaat attcctttct 43440
gattgcagca gccgaaacat tagcatatgc cgtgttatta gacaaaataa caatagagcc 43500
gccattagct aaccattctg tggcaaaaat ggatactgct ttagttttac cggattggcg 43560
cccgccatca agttttaagg tgcagcattc tttaaacagg gtttgtgaat caggtacata 43620
aaacccacta ttacaaatgt gttctactct agcatcagaa tggtttgcaa aagcattcat 43680
cagggataga taactaccgg ttaaaaacgt tttcataatt gtctcttttt aagttgtggg 43740
gccattcctt ggcacattaa gtcgtccatg tatccgtatg taaacccttt accgcacttg 43800
ggctcgacct tattacaggt agggaaaggt ccatcactca gaggacgcga cgttcatgag 43860
gagagggccg gcttgccttt attagaaaga accagagcct ttaattgtgt tctggcgacc 43920
tttattttcc aattcagagt ggtcgatttc atatgcttgt gctacaccaa aggccttttt 43980
aactttagct aaagaacctt tagatgtaac aatattaaaa gtattacctt tggtaaaatc 44040
aaccaaatcc acttgtacac cctgcttgcc gaggcttgct acaatagcat caacatattg 44100
ttggtctaaa ttgccttgaa caccaatttg aaatgcctta ggagctttgg cttctgtgat 44160
aaattcttga taagttttca tattattcct taagttgata gaagtattct atcacggatt 44220
taattaagcg taaatagcct tgccataatg tttgtaccag gtaggacgct gtgcaatttt 44280
ttcgtccaaa cgagcctgag atatagcaat agaagcttcg tgtggagtat agtcaccacg 44340
gaattcctga ggaatatcac taatgtcctg gaccgtagtg tccttgatat taaaaccacg 44400
ttttaaacat tcggctataa gctcgatctg acgtttacgt aaaaattcaa gcttatcgta 44460
aaagaatgta acatgacctg taccaaggat aaaagtagga ctgattttga aatcacggac 44520
acgtttacca ttagcaacat gcttacgaac tgcaccgaaa acacgtggta attcacggta 44580
ctcagccatt aagtgttggt cagccaattc agatactaag gtaaggttga tacgagtcat 44640
tttagtgttc tccatgtttg tatgagaaca ctatatcaca gctatcgtaa aagtaaattg 44700
ttatttacct ttaattgctt tagctgcttc gatagccgct tgctgaaggt catccataga 44760
cataccgaac ttagaagcaa agttatcaat tttcttttcg acagaattca aaggcttggc 44820
ctgtttacct tcattagcgc cagggagagc gagaatacgc tctttgtcaa tataaaggct 44880
tacaagtttc ttacggtctt tatctggcaa atcatgaaat gaatgggcct ttttatttac 44940
ggcggcttct aatttacccg cacttactcg cgcttcggtg ataaattctt gataggtttt 45000
catatgtttc ctttaaatgt aaataggtcc gagtattcgc tttattaatt accacgggca 45060
gcattagcaa cggcgtaagc gtactgaata ttagcgtctt taaacgtacc tttagaggtg 45120
tctatttctg ccttaaagcc gcctttagcc ataacatcgg caaattcttt acggaaggcc 45180
attgcatcaa gacccttcca tgttgatttg tgcttggcaa attcaagacc ggcgaagttg 45240
accgccttag ccaatttatt atcaatagtc catttacctg ctttaggtac aaatacagga 45300
cctttctgtt tagagaacag ttttaaattc cagcgacgaa ggtcaccgtc agctttaaca 45360
aaagctgcgt ccaagttact agcaacaaca tcttggatat gggcaaattt aagtccatca 45420
gcttcaatat ttaggtcgtt acgccagcga agtccttccc aggcgaaagc tttaaagtcg 45480
gaagcttttg tagccaagta ccgttcaata ggagctgttt tagcgtcaaa accgtttcct 45540
gggttgtcaa cgccgtttcc tttgtaagtc cactcatctt tattaatgcc ttggaccttt 45600
cctacagaag cttcggcgat aaattcttta tacgttttca tacgggttcc ttaaaggtaa 45660
atattttaat tggtctgttc aagtaactgt agatatacta tcacaattct aggagatgta 45720
aacttattta taggtcttca tccaattctt gaacaaagcc gcgacgtctt tctctttaac 45780
gttcagttta atgtccaaca ttttaccacc cgctgctctg gtttggcgaa tcttagcagt 45840
accggtttcg ccattccact caacataata ctgtccagtg ttcattgcaa taccatcacc 45900
gtagtcttca tttttagaag tggtgaatgc tagcttcata gtcttagata cacgagcctg 45960
catgcctgtc tgcagagcgt tacgaacgcg aataacctga ggagtggcct gggtcaagtt 46020
ctcattcagt tcttcagtga actcttcaga ttcaaacatc gccaaaagtt ctttagatgc 46080
aggaattaca ttctctgcga taaattcatt ataagttttc atatgctttc caagtacctg 46140
ttttaaatgt tgaaatcacg cgcttagcac gattaggggt ttgtttatac caacgggatt 46200
gagccaggtt aactgccgca tcgttccaac gtttctgttg gagcatacgt aaagagttag 46260
tgaaccctgc tacacctgct tcacccattt ggaagaccat gttaattaaa gcacaacgac 46320
gaacttcgtc caatacattg taaacaggtt tcaatttagg attacgcaga atagctctac 46380
gagcattttc aaccgatcgg ttaaagagtt gttcggcttc agccatagta atacgaccat 46440
tacaaactcg gcccataagc ttatcaagtt cagcacgagc aacatcttta gatgggttct 46500
tggtaactaa ctggccaata ccaatagtcc aataaccttc agtgtcttta taaagattta 46560
aatcaagacc ttcgtcttga cgtaacatat caaaaatatc cataatacct cctgagtata 46620
ggaggtattt atatcaaaag agcgaatcta aaaccttaaa catcgactta cccatgacat 46680
attcccattg cggacgttta atcaaggcga acgcatcgaa ttcaggaata gtacgaccat 46740
cagggaatgt atggtaagcc gtacatttgc aatccttgaa ctgctcgtgt tccacaggca 46800
ccgtatataa gaacagatgt agattcttat tgcttgaata tttgaactcg cctaggtctt 46860
tcaggaatgc aggatcgtat gctgtgaatc caatctcttc ttcggtttcg cgcattgccg 46920
cttgaatagg ctcttcgcct ggttcgacat gacctttagg aatgtcccat ttatgacgca 46980
tgttctctgg attacgagag cctgttacac gacccataac caattcttta tcggcagtca 47040
tgaacaaaat accggcagat agttctttca ctttcttact catcgtctcg ttcccatgat 47100
tgtttaaaga tatctcgtat aataatttca acacacgttt ctgttgacgg actttcacta 47160
tcagatattt ggaccatata atcagaaata ggtcggaaca tatccaagtc gctttctaaa 47220
tcttctttga ttttctcttc tgacgttccg gtatcatagg aatacagata agaatcacat 47280
gactcagatt taatataaat tgcaatactc atttacggca ttccttaata aaagagttta 47340
atgtattttt cttagtgata tcgtcatata cctttttaac tttagaaata cgaaaaggta 47400
cttcgataac cgaggtccat aaaaatgatg cgataagacc taagatagca gcagacatcg 47460
ctgaagcgaa tacacaaata ggcaggtcat tatctgttgt caggaaaaac cctaggagtg 47520
ggaaaaataa tatacccatc caaacataga atctagaact caccaatttg tcgtattcat 47580
cactccaggc acggaagccg tattttttgc tataacaaat caatgggtct ggagtttgtt 47640
ctttatgtgg ttccgcttgc cagccgttta cgatatagcc cattttatat tcctcaatta 47700
aaagctgttt catttcggca gtacaacccg accaatctat cgtactagct ggaattcctt 47760
catcaccatc atcaatattt cgccaggact ttttaataac catattctca ccactcggga 47820
taataattcc ggcattttcc gaccgacgga tgaagtttgc atcaatgccc atacaccctg 47880
gttcataaag ggccattacc agccctccat agggaattcc agatatactt gagcattaac 47940
acggatttca ttagtaatct ttttaacacg gtcggtatta cgagacacac gaccaaacca 48000
gcgccaaccg ttacttactg cacgagaacc cgtatgccat gtctgccaat caaactggag 48060
caacgtgcgg tcaggagcat cccacttggt taattcattg gactcaattt tttccagaac 48120
ttctttatgc cactggcgat agataagttc gccttcagga atctggctaa attgcgcagt 48180
tccggttgca aaatgggtag gacacacatc agcgttaaca agaccaagaa tatgttcaga 48240
atggtaacga ggattatcat aatcaggttg ccctgcggta ataaagtgtt ggccaaccgg 48300
aatatccgga cgtggtacat catcatggtg gaagcctgga attgcagggt accagccggg 48360
cattaacatg tgtacacggg aatcaaatac aatatcaggc ccacattgcc aatcttcagg 48420
caggttttca ataaagctac gagtaatagg accaccgtgt ttatgagcaa aataagcatc 48480
acaattaaag aacataggct catttttaat catatcatta ctgatatctt gagcaaaatt 48540
acctactata gaagctttgg aattaaaagt ttttggacca ttcataatat tttcctcact 48600
tactttttgt tgaaaaagta cattttacct ttaggggata aggatacacg aagtgcgtta 48660
ccaataccaa ctgaacattt aaccaggtca gcagatttta attcaccgaa tgcttgacga 48720
aggtcaccgt cacgagtgtt aaccatcagg catttagcac cagctgcacg aacttcgttt 48780
aacatgttga ttgcttggtt agaaagtttc attttattct ccatttcact ctgttgtttt 48840
gataggtcta tagtatcaca cctatagacc ttgtaaacaa ttttatgcaa ttatttttcg 48900
aaaggacgaa ttaaatgttg gttacgctta aaccgttcaa tgtagtcgtt ttcacctaaa 48960
gtcttgtaca tattaaccac agcttggtag ttttcccagg cgtactcacg gaaccaacct 49020
gaagtgattg aggtgcacac tttctcaaga gccatataga aacttaatga tggtgaaata 49080
ttgaagtcat taggaacctg tgaacgttct agtgccagga cacaagtttc ttcatacaca 49140
ccagctaatt taatagcttc aggcaaagct tcaaacttct cacgagaagt catgacttca 49200
gaaccttcct tcatataaaa ggtatatgca gggcgtcctg ccaatgctac tgcttcgtgg 49260
atggagtcat ggtccagcgt ataaatggta tcattaaaga atgatgattt gttaacgtct 49320
aatttagggt gagaatagct caacgtttct ttttgacgtt gcagcataat ttcctggagt 49380
tcttcgttca gggtcacgcc tttattacga aggtatttga tgtgggacat agttttcaag 49440
aagaacggat tattcttcag gaaacgatga gaggttttga tagccagaca gatatcaggg 49500
gttgcccaat agaaaccagt aagacggtcc tttttaatat gattttcagc atatttcagg 49560
agacgatagc ttgaggtgta gtcttcatct tggagctcac cagtgatttc tcgtacgtta 49620
gtcagggcac ggacgatata agcttcgaaa taggtttctt tgccgttgta catgcattta 49680
aaagcctgga catcagggtt atccacagga acatgagcac cgaacatacg tgctttaaag 49740
tggttccatg agccttggtc ggcaatgaaa tcccaatcag aatttttgat atacttattt 49800
tcaatcagac cagcgtggtg cagtgcacga gaaccaataa ctaacatcat aatattttcc 49860
tcagtaaact taaatttcag caacgtaagt gttatgcaat tcccacatat catcggaatt 49920
actctcaacg ataggaatta tctcattaga aatttcttct gcataagggt cgttgataca 49980
gtgggcatct tcaaaacgaa caccgtaatc agacttctta taagcaaagc cataaatctt 50040
tttaaacctg gcacgagtaa tgcgtaccgg ttcattagac ttatcggaca tcggagcata 50100
ataccacata tgttctcctc atgtttgtgt agggtaatag taacacgtat ttttagagtt 50160
gtacatcact tctgcaatat tctaaaaata atttatcgtt gtctactgta tcccaacgac 50220
gccaagatgg gttccagacc aaagcgttgt caccacaatc attgagctta aaatggtcgt 50280
agtacatagc tatacgtcta gtttcgtcac cagagaaccc cagtataggc tcgccatggg 50340
tgtgatacat atgatggtgc attgagaggt cgcatttgta aaacatctca cgtttaccac 50400
gaacgaacaa gaaggcttgc ccattcatat agaattcttt atctgttttc aaaagatatt 50460
tgaatactga atctttatgc ataagtcctc ctaccacatc catgtggtta aattattttc 50520
ctaacgaaac acgagtaggt tttttaccaa aatagtcttc gtaagaacca tctaaacggc 50580
ccgctttaga ccgacaatat gaatcgtact ttttgtaata agtcatctca gtattataac 50640
gtgggtgtct atcggccata ataatactta gtggccaacc tttggcataa tcgcgaagac 50700
tgtttatttt acgaatgtat cgttttttca attttagcat gagcttgggt accagatttt 50760
accatcggca cgagcaacga aggtacgacc agcttcttcg ccataacaag agctattcag 50820
ccaatcttcg agacgaactt caccgtcata atcgtcgagc tcaacaccaa aatcctgagc 50880
agaagccata tcttttactt tcttatacag tgcagccagt tcaagtgccg ctttttctaa 50940
ttcattaata tcagacattt ttatttcctt agcaagacat agaagaagta aaccagaaac 51000
catcaccatc aggaatgccg taatcatcac ggacccattc gtaatcatca tattccgggt 51060
tctttggaga aatgtattgt ccacgaccag aaacatggaa ctcttcacct gtttcgtcag 51120
ccacggactg gcctttacgt actaattcac ggatttgttt ttcaatttca tcaatagtca 51180
ttttatttcc ttagcattcg taagaggagg acacccaaga ggtaccacta atagtaatac 51240
aaccgttata aagcgtgata tgacgttcca ggtcacgagc gccatcgata tagatatcag 51300
cttcttcgcg ttcttcttta caaatctgga taacgttttc aatagctgcg gctgcagtac 51360
ggattgcaca atctagttca cgagacataa taattcctta acattcagaa gaagaggata 51420
cccatccacc attttctagg ctggtagtgt aatcatgttg gtttacaata gcgtactgag 51480
cttcaccgta ttcttcccag tgggcaaggt cggctttcag ggcgccagga gaataatagt 51540
caccgcccat accgcgagca gggtatatat taaaatgagt ctcatatttg ttagcaattt 51600
cctcagcacg acgaatagct ttatgaatat catttactgc ttcagccagt tctttatttt 51660
tatggtaatc attcatcata gcgtttcctt agcacattgc cgaagaggag acccaagcac 51720
caactgtaac gacaccgttt tcaacttcac cgccattgtt ttcaatttca tctttaaacc 51780
actgggagca ttcataaccg acaggataat atgtacggcc tgaaccataa tcaccggtgc 51840
cgaattggat accatactta tcggcaatag cttcgcattc atgttcgatg gcatctactt 51900
tattcagaag agcatagata gccttttctg cagacagcgc gctgttgtat tcagggattt 51960
caatttcaat tttattcatg atttacattc cttaataaag gtttcaaggt cattacgttt 52020
agtttgtttt acatactcat tataattagc catctctaaa gcatatctct tacggatggg 52080
agcattcaaa gcgtttgtat ggcaaatatc atacacaaca gggataaaat aagccacgac 52140
agcaggagcg attatcatat agaaacccat ctcaataggc atgattcctt cgattgccgc 52200
cataaccgtg gtcattacca gaccaaccag accaccgagc ataccggtcg caattcccat 52260
aaataaggaa atagcaatat catattcagc caattgataa acatgtgatg aaagactagg 52320
ccgttccatt ttgaacctct ttagcgtatt cacggcattc agcaataaaa cgattaagct 52380
tccgttgttg tttacgactt tctaatgtgt actcagtagt taagatacca agctcggctt 52440
tatcataatt tttaatatca gagtaagatg ggcgacggtc aaccattcca aatacatcac 52500
cattttctaa agctacatag catactaaat ggtaatcatc gtctgccata ttaagaagca 52560
cacaatcagc gctctcgttt aaagaatata ctgaataacg tagtccagcg aattccactc 52620
gttgaatagc cagatttacg tcaataattt ccaaagcatc ttcaaaagaa aggtcttcag 52680
ctaaagcaaa aataaaaggt aatttggtag tatcgccacg gctagatgtt ctgcttaaga 52740
aatcgtttga atagcctagg tcttggcgaa ttctataaag aactgaattg gtttcatggg 52800
aaagaccact atttttaaac caatcaatat ttgatataag gttatcatat aaactcataa 52860
tattctcctc tcctccaaat agggagaccg aagtctcccg gtaacattac ttaagtgaat 52920
taatgtagtc ttcgatatca gcagaagtcg tatccattcc aacttgcggg cctttaaacg 52980
tttctacacg catcagggtg tcttcaatat caatcttagt cagtgcagcg atttcaacaa 53040
catcatcggc agtagcaata cccagggcag ccatattacg agtttcacga atgtactcaa 53100
gcttaaccgc tagttcctgg cgagagtcat caagttcctt gaccttaagc ttaatttcat 53160
tacgcatttc aacataatca tcggctttct tacgaagttg agtagctgta cgacgataaa 53220
ggagacccag tttagcatgt acctggacat cagcgccttc ggcaatcagt ttacgaattt 53280
cacgttcttt agaagcagcg agctggtctt tttcattagc caatgcacga atacgttttt 53340
cttcattcac agacttaaca tgagcagtct ggagttcagt gattttatca atcagagtag 53400
aagcagcttt ggtgtattgg tcttcgattg acaggttctg agccattgcg gtgcccagtt 53460
tagaacgaat gaattcaacg attttcttta aagtgttcat agtatttcct tcagttggtt 53520
aacgttttgt aatccatgag gacattatac cctgtcctct gaggtttgta aacattttat 53580
ttcatttttg cgaggcaaat ttcattggct tcccattgag cttgcttaat aatagctttg 53640
gatacaggag ccctttggcc ataagttttt gacgttgaga gaacaatatg tttgtttgct 53700
tcattatgcc agccccatga tttttcgccg tgagtacctt taactacagc tgacacctca 53760
acagagcaac caccatcaga aatcttggtt tcgacaaccc attcatttct ctcagcagct 53820
tcaatttcta atctagtttt ttcttcatac atcgcggccc aatcagtttt tgccaagttg 53880
aaagtaagag ctttctctag ttctttggca tatttttgtt gttcaggtgt taatgaatta 53940
tacaactctt gcatttcttt atcttcgata ttcattatgt tctcctcaaa ttatgggctc 54000
ataatatctt aatcatgagc ccgtgtaaac gttttatttc atattattga aataattttc 54060
tgcatcaaaa tcattaccat ggtaaacttt ggtagacgat ttggcgtaac cttcagctga 54120
gaacatatta atcacaactt taattgtata ccactgtcca tcttcattac ccattactgc 54180
ataggtttca tacaccgggt gttcaggacc gataacttta atatcgttaa cagtagcacc 54240
aaattcttca ggaacgcatt tcataaagaa attaaacact tcaccataat tatccatttt 54300
actctccttc acactgttgt tttgataggt ctatagtatc atgttctacg aaagagtaaa 54360
catctttttt aaacttttta gaaacaaaaa aaggcccaac ctttcggaag ggcctagaat 54420
cagttcttgt agaaccggaa tgggtttatg tggaaggcta acatagcctt agggatttta 54480
cgagacaaaa gactcttaag tttccaacca cagtatacac gaaggtaaaa ggtaatccca 54540
cctactttaa gatacggaac tgaagcaaag actccccatg cttcgtcatt ccacatccat 54600
aaccatccat gatgagcttt atcaggagaa ccggatttaa cgtcaggatt accacgataa 54660
tggaattctg agctacaatc gcgtccaagt ttatggtaag caaagttata agctttattt 54720
cgccatagcc aagctaccct ctggagataa acaccgcccg gcattttcct gattttagcc 54780
caacgtttaa tatgaccttt gtcaccgtca attggattat cgtatgtcat catccaatca 54840
aagccataag gcaatttacc ggtcttttta ttatggaaag gaactacaaa aggcgcaagg 54900
ataacggcca gaaccataga gatgaaatcc agtggaacca acagaaccca actcaaatat 54960
tttaaaagtt tcatatattt ctctaagtta accaaaaaag ccccagacgg ggctttcgtt 55020
atttgatttg tttagcagac cagatacggt ctttgatgat tttctgaata tcttcaacat 55080
actctaagtc gtgagcatgt ggattatctt tgaagctatg tgctcgtgcc agtttctggc 55140
cttctgtttt gattactaaa agctctttaa gaattgcttc atacttagaa ataattcctt 55200
tggcgatatt tttttcttga gcggctttag ggtccgcttt tgacgcaggt gctttacctg 55260
tagctttctg gaacaattca cctgatgcag ctaggctttt aaaaactcgg ctaacagtat 55320
tggcattagt aaaaccttcg gctttaaaat ctttaataaa acggaaacgt tcttcatcag 55380
aggcgtcttt gtaagaatat ttacctgctt gaattgctgc aatcgcagcg gcttttacat 55440
ctgaactaga ttgttcagtc aaaaattcat tgtaagtttt cattattatt tcctaagtta 55500
attaacttat ctatttatta tgccaaaaag ccccaacctt tcggaagggg ctatgccttg 55560
cggcaacctt gtcggggttc cacctgctag gcaagtgttt gtacgaaacg ccaggattcg 55620
aacccggtta ttaagtagtt gacgctactc aatattttta aaaggccata tctcgaccat 55680
atccgaacgt tccgtcaaaa acgctactcg gcttacggca aagatatttc ctcgaatcga 55740
taattctgtg cgccgtttct gctgtgatgt aaggggacat caacaaatca taaagattta 55800
ttaatgtcag tccttaaaca gggaacatca gtccgacgac ttaccggtag cgacccggtt 55860
tcttgtttgt tgcgccggtg aatgctggta atcagtcttc atacgacggc ttgactatat 55920
aatagtcttc atttggtatc ccgccctggg atcgaaccag gaccgcaaac ttagaaggat 55980
cgtatgctat ccattacacc agcgggacgt agttggtgac ccagaccaga tttgaactgg 56040
taacctttcc cttatgaggg gactgctgct aaccattgag ctacagggcc ttaaatcaaa 56100
ctacaaatcc agcaggagca ttatcatctt taatcatatg ctgaattgta tgataagtca 56160
tttcttctgg agcaaccaaa taggctgcga cgttaaccag tggaattctt ttgggcttag 56220
tgaatgtgga atccgctatt gacataaagg ctttgccgtc tcgttcaact tcaccaaatt 56280
gacattcata tgaaatagaa caacgtttgg tagtggttgt cttggttgcc gggtcataaa 56340
aagctaattt taatactaac ataaacacct caaataaaat taagtaaagt aagtttgatt 56400
aatagacctt gtctattatg aaaggctctt tgagggaaga acctttggta atagagggtt 56460
acttaataat gttagagtaa taatatcaca ttactcttaa agcatattac tatttttagg 56520
aatagtctgg tcaaatttga ttcattgtgg ccacatatta atgtaatcaa gtttaataga 56580
agcaatcttc aaaggatttt taaagatgtc gtattcgatc aatccgtttt cagttgcggt 56640
gtagaaagta aagttaacag aattataacg gcgaccatta acttttagtt taacgtcgct 56700
tgaactacgg ccaatattaa cctgttggac atcaagcaca gcacctttgc caaagttgcg 56760
aatcagtagc tctgctgcaa cctggtctga attatatcca ttctctggat tagtaacctt 56820
aacgtataac atttaaccct cgtctacaat agtatgggta ttggcattaa caatctgcca 56880
ccagtcaaaa cgatcggagc cgtaacgagg ctttttctca ttttcgttaa taatatcacg 56940
tagttcgtct tcagaaaatg ctttagcgat taaatcggta tagccaccac gtgggtaata 57000
gttgtcacct gcgaacagaa ggaaatttac tttaccagaa ggaacatatg cttccttagg 57060
atacttgttt cctgcttggt ctaccacttc aatataacgg taaggaatat cggtactttc 57120
aacccattgc caagctgcag caggggattc aaaagcatct acacctaaac ggttatcttc 57180
atctttagac ggattatttt cataatccgc atatacataa tattcaatgt tcattattca 57240
cctttagaga ttttatccat aacgaaagaa attgaaccaa ttaagaatgc cactactaaa 57300
gagattatat tctcggaagt tgaaagcata tcgagcatga atcctgcaaa catactaaag 57360
ccaaaagcag taacagcggc cagtgcagta acatttctaa ttaattcaca acgtttcatt 57420
ttattctcca atcactcatt tgttttgata gggctatagt accatcacta aagcccgttg 57480
taaacaatta ttttaaataa attgcatact ttttataacc ggctgtttcg tgacgtagcc 57540
ctttttcatt agcaaaacgt tcaatattgt taatttgatt ctggtcaagt tctgaagtat 57600
caaatacaaa aaagtttcgc ttattgccta aagttacgtg attagtcaaa tcgatgttat 57660
agagatgatt tatattatca atcatggtct taacagattt gttaattttt acttcttcat 57720
taagaataga ttcagcgata aattcttggt atgatttcat tttattcagc accagcggct 57780
ttcaaaagtt ttttaagatt ggcagtgcct tgagcagaaa atgtgacttt gccgtctttt 57840
tcgccgatgc tcccggtcaa tttagcgagc ttatcactag ggactttttt aaaatcagcc 57900
aatgtaccgt caaaggtttt tgtaacaacc ggcagttggt cttcttgttt tttagcttcg 57960
gtaataaatt cttgataagt tttcattttt atttccatgt ggttagtttg ttttgatagg 58020
tctatagtat catgcctata gaccttgtaa acaacttttt taaattattt tagccatgaa 58080
gaattttcag agacccagct atctatatct gattgtgggc caaagaagta ggcaacccca 58140
ttagataact ctcctgaaag ccaatttata cctttcaggc tttctttaaa ttcttcagga 58200
gtacaagaaa cctctattgc caccgaagag gctggttcca ttgcttccgt taagaattcg 58260
ttgtaggttt tcattttaaa tcctcggccc agtcgagctt caagggttct ttatattctc 58320
tgtctaaaac aacaggaatc tggacatctc cactaaaggt aagaggtcct acattataag 58380
acaatgtgat atgaggggta taatcatcaa aatcgtgcgt agcacctaag gtacgagcat 58440
actgatggcg gcatttaaga tactctgaat tgagaaccaa taccaggaca ggagaatcac 58500
cgtgtttcca cacttcaaga tgtcctgacg aagcaacttc aaaacttccg gatgcaacgg 58560
tgtatggaac gttgactctt gaatagcaga ttgtagaatg gaatttttca cgaggaactg 58620
gattaggaac ctttaaagtg cgctgaaggt tttccagcgc atctaaagtt aattcagaga 58680
attttgcagc aacgtataga ccttgagcaa aatcttcggt tttcattatt cttcgtcaga 58740
agcttctgga accagggcat taacggcatc gatgatatca tcaattttaa tctgctcgcc 58800
ttcaatacca actgcgtggc agattttacc aagggcttcc tgaaggatac gagattcctg 58860
ctgcgcctga gcaacagcat cctgggtatc aagaatacgg gatttcagaa gaacgatttc 58920
ggactgcagt ttctgttcgg tagtttgttc agacattttt atttcctaat aatttatcaa 58980
tagtagtgta tagttcagaa agagtgccgt tattttcaac aacaacgtca ccaggtaaaa 59040
ttggcagacc cgcttcagtg atgtgcgagt cttgtacttg accggtttca gagcgaacta 59100
catgaataat cgtagcaccc atcgctctga gcgaatcaat ttcatgtgtt tgacgaacat 59160
caggtacgac atagtatttc gcatcagagt atattttatc aaaatagtct aaagcgaaca 59220
acttaaccca atacatctta tcaaattggt taacaataat atcagtccca agggtctgca 59280
tgagacgacg tactgaccaa ttgttatttt tatttattac ttcaaacagt tggtcttttg 59340
tttcttcaga cagatactgg actggggtaa gaccataatg atatgcggta cgaacatcca 59400
ttcctggaat aggaaggata ttattcagtt tgacaatagc attttcaaag atatcaatca 59460
catcatatgg ttttaaagga aggatttctt cacggtcgta accgatacct tcaaaacagt 59520
tgaaatccag tttaggcata taactacggt cgaatacagg gtcatcagag atgtattcat 59580
aggcttcagc cagatacttt ttaataggac ctgcgagctg aaattttacc gaatccatat 59640
tttcgattac atagttagca acggtatcct taccgctacg tttgattcct acaattgata 59700
ttagtttcat tattttctca tagatggatg catagacata cgagccacac gttgttcggc 59760
atacgaatca atttgtggac gacctgtaac tattgtacca tctatttcta cagcaaacga 59820
tttgaagttg aatgttgctg tggcgattat tgctgggtca gaatcctctt tataagagta 59880
ctggatttcc gagaggtcag atggccaacc gccatagtaa tgaatgctca ttacgatttt 59940
ctgtttgtta ttatcaagga tatggagcgt aattgcttca ggtaagcctt taggatgcca 60000
agcttcggat tcatgggtta cgtagttgtt taatgacaac atccacttat aaacgtcaag 60060
ccatgatttc aattcacggt ctacaagaaa gttcacgatc aatgggtcga attctacagt 60120
agaacctggc agcttagcac gatgtatgcc ctgggtcgat cctgggacgt ctgagatcgg 60180
aatatggata ccgggtagtg ttacatcttg tacgttcaat ttgaatgact gtgtcattcc 60240
tgagtcacta acctctaaga taaagttggt ggtgttagtt tggttaaata aaccgttcat 60300
aaggttccta tattgcttaa gtcccagaca gtgtataatg gtcctaggtc tgttccattc 60360
aataactggc tgggataata gattatgaat tcttccatac tttctgagcc gagtaacgct 60420
tgcctttaga catgaattgc tgaagtggaa gcatgaccac attggcccaa tcagatggtt 60480
ttatctctac taaaggtccc ttaatatttc cagggatata agccttaatc atcacgtctg 60540
caccagcgaa tccttttacc ttactccaat cgatttttaa tttagtcgag ttagtaatgg 60600
taggcgtact cgcgtattgc ttcagcaatt cttccagaaa ttgttggcgt gctttaggcg 60660
ggatatagtg taagttcagc ccgtacatta aattatgctt acctaaccca agataaatga 60720
ttaaaggata tttgtcccag tacggtaggg tatccttgtg tttagcgtca tagatataag 60780
cataaagctt accaggagat ggtttagata cctggtgtcc acgaattcct ttctttaatg 60840
tttctgtaaa ccatttagct gatttattat ttacagcagc gccttcgtta gcaatcttat 60900
cacgaatact ctttctaaaa ctattcacca aaattaattg acgttcggct ttggttaatt 60960
tattgccagg tttattctga agtttttcaa cctgtacagc agttttaatt cggctcgagt 61020
atcgagacat cgcagatgta aagctagaat acttgatgcc tttatcttca gcgaatttct 61080
tagccgagac acctttagcc ttagcgttgg catattcaac gcctaaagtt atccattgtt 61140
gttctgaacg agtgggcttg gaaccttttg tggtttcagt agcctcattg atgtaggaaa 61200
atatactcat cctttccatc ctaatttttt cagtgaatgt tcggtaatca atctaaaggt 61260
gatacccatt ttatctgctg tagatttagc tgctttccac ttatcggtat taacggacca 61320
agtataatgt tcgttgatat atctcttttt agcagccgta gtcattttaa caggcaccgc 61380
aggagcatgg gtttctttaa aaggtttgac ttcaaaaaag aattgttgac ctgtatcaaa 61440
tttaacccag aagtccataa aatatcgtct tttctttcct tcagcattgc aaaagtaagg 61500
aatgactacc tcttccgaat tccactggac tacattaggg tggttgtcaa gccaacgcat 61560
aaaccatgct tcccaagagg aacgatattg gattttcttc cagtcacctt tatatttttg 61620
taagtttgta ggtttaaatt tccctgagta agccatagtc gcctccttat aaatattaat 61680
attatttata ctcggaggcc ctatgctctt ctcatttttc gatcctatcg attacgaatc 61740
aaaaacagtc aagccagatt ccggctcatt aacaaatgcc gatgtactga gcgtgccgat 61800
gactgatata tttagaaatt ataaagaata tttcgataaa gtggctaaaa attatacact 61860
aaagacttat tatatcaatg gggcccctcg tccagaagaa ttggctaatc aactttatgg 61920
caacgtccaa ttatattggg ttttattgat gtgcaataat acatatgacc cctattacgg 61980
gtggattaca ggtcaagaag ttgcatatca agcggcaatc caaagatatt ctactgcagg 62040
cggtaatcaa gttctttatc atgttaatga aaagggtgag aaattctgga atcttgttaa 62100
cactccagaa aacccgtata cttggtatga taaaggcgat acagaaaaac gctatcctca 62160
atatgagggc cctttggctg cagtagatat ttacgaggat gctattcgta aaaatgaata 62220
taagcgcgaa ataaagattg tagaccctaa tgatattgag tcctttattt ctgcccttat 62280
tcgcgaaatg gagaaagccc tctaatgatt aacatgtctg ataatgtaag ttggttcgtc 62340
ggtgtagttg aagaccgaat ggacccgctc aaacaaggcc gagtacgcgt gcgcgtatgg 62400
ggtatgcatc cctatgaaaa ggtacaaggc cctgtaaaag gtcttcgtac agaagattta 62460
ccatggatgt cggtattaat gcctacatct tctgcctctg tttctggtat acaaaccgct 62520
atgactggta tggtccctgg tacacaagtt tatggccact ttcttgataa gtggaaatta 62580
aacggactcg tccttggtac atacggttcc gcttcaaaac aaaaagcaaa ccctaatgaa 62640
ggctttagtg acccgacagg tcaatatcca ctttatttag gtaatgatgc cgctgcacta 62700
aaccgaggtg gtgaagttgg atatgatgcc acttctaacg taatacaaga tgcaaacact 62760
gatgtaggta ttaatcctga tggtttagat ttaagtcaag tcaaacctga tgataatcct 62820
aatttcacaa tagaaaacat gcttcatcgt gatgaagggc ttagactgaa ggtatattgg 62880
gacaccgaag gatatcctac tataggtata ggccacctta ttacgccaca acctattaga 62940
gatatgggtc ggataaacaa aatattatct aatcaggtag gacgagaagt taaaggtaac 63000
cctggtgcaa tatcaatgga tgaggcttct aaattattcc aagaagacct taaaaaagtc 63060
caaaacgata taggtaggca tagtgttgtg ggtcctgttt acaataaaga aaaccgttca 63120
agacaaatgg ctcttgaaaa catggctttc caaatggggt taggcgggct tgctaaattc 63180
cgtggaatgc ttagtgcaat gttaataggc gattataaaa aggcatttga agaagcccgt 63240
aattcagtgt ggtttaacca aactaaagga cgtgcatcaa gggtatcaat gattatcctt 63300
acaggtaata tggaatcata cggtattatg gccccaaaag aaaggtcatt taaagggcgt 63360
tcgtatagaa tgattcaaac ctttgctgct cctgcaaatt cagacccttc cgacccatgg 63420
actccagaag acacaaggat tctttttaaa gaacctgatt ctagttataa aggtgaatac 63480
ccgtatgtcc aaaccatgca gactgaaggt ggacacgtcc aagaatttga taacacccca 63540
gggcaagaac gttatcgttt aatccatcct acaggtagtt atgaagaagt tgctcctgac 63600
ggacgtaaaa cttctaagac ggtagccgat ggatattata tgacccaagg cgattctaat 63660
acttatgttg gtggtaataa taaagtcaat ataggtggtg atgaaacata ttataatatg 63720
gcaaacgtac gccgtcaaac tgacgggtcc gaaagcatcc atattcgcgg taatgaaact 63780
aaaactgtag aaggtgatgg gacccttatt gttaaaggga acgttacagt tattgtcgag 63840
ggtaatgctg atataactgt taaaggtgat gcaaaaacat tagttgaagg caaccatgac 63900
tatacagtaa atggaaacgt taaatggtct gtaaatggaa acgttgatat gactgttgca 63960
ggcaattggt ccgagactat ggcttcaatg agttctattg catctggaca atatactatt 64020
gatggtagcc gtgtggatgt ggggttataa tgaatttagt ttataaaatg acctttgaat 64080
ctcgtcttaa aaataaaact cctccctatt attatgtagg gagtaaaact aattgttttt 64140
tcgatggtaa gaatataata gatgaagatg gaaaaattta taaaacttct agtaaagtta 64200
aggaacttaa ggattcgttt ttattagaat ctcctaaaat agaaatactt tatttccaat 64260
tagtaggatt tgaaagtatt accgagatag aagagaaatt tcaaagagct atagatttag 64320
aaagttggca caacgaatat tttaacttgt catatgctaa tggcgaattt acaacatatg 64380
gtaagatttg gactgttaaa gaaaaatccg aaatgtcttc tataatgaaa gatagcgaag 64440
cccataaaaa aggccgtgtc gttataagtt ttaaaaatac aggtcgcaaa ttatccaagg 64500
aagattctat acgaaaatcc gatttgatga aagctctatg gtctgatatt gaatataaag 64560
aacgcctttc aaaagcccac tcaaagcctt tatcaacatc acataaggaa agtatacaat 64620
ttgcatggaa aaacgaatct ttaagggcgg aaaagggtaa agtaacaaag aaaaattcta 64680
ggtctaaagg cgtttggata tatgctaatg aaatttacaa agtttttaaa gaaaaccctt 64740
ctataggaga acccacattt agaaagacct gtgtaagctt gggattacct gatagtagtt 64800
atgtcgccat taggcgagct ttttctaata acgattttga atttcttgat gtggagattt 64860
acaatggcta atatcctacc tatgagcact gatttaggag actccataga aggagctagt 64920
atagatatat tttttacagc tcaattagaa acaaacgaaa cattagtcga aataaatata 64980
actgaatatg aggccacccc tggcattatt gtcgatggcg cccatttata tggaacctac 65040
gaatcggtat ttggattctc tgaggatgca ttaaaatacc gattaaacga cgaatttaaa 65100
actgccggtt catggaaaga tttgccagag gacgagagca ctcaattgta cctctggaaa 65160
gcccctagca atctccagaa gaccttttct tatactgtca cattaatcta tgactttcag 65220
gaagagacgt caggaggtga tacagggaac tcaggcggta gtaactctag agctggcgca 65280
gaaaccgacc cacctcccgc tcctgtaaga aaaaccctta ctaaggttta taccaaggtt 65340
atagtgggta attggagcaa atgggctaat caattaagag aatatgtata tgcgaggcca 65400
taatgtcagg cttaagttac aaccaatgcg taacggcagg tcatgaagca tggcctccta 65460
cagtaataaa tgccacccaa ggtaaagtat ttacaggtgg tattcctgta ttagttgcag 65520
gagaccctat tacagaacat acagaaatta aaaaaccata tgaaacccac ggtggggtaa 65580
cccaacctag aacatcaaag gtatatgtta caggcaaaaa ggctgtccag atggcagacc 65640
ctatttcatg cggagataca gtcgcacaag cctcatccaa agtattcata aaataggaat 65700
taaaatggct actcctacga attaccaatt aacaagaacc gttaacgcta tcccaaaagt 65760
atttgtggga gctacgtttg aagaaattaa aaagaatatt atagactggc tttctagcca 65820
ggacgaattt aaggattatg atttcgttgg ttctcgaatg aatatcctta ttgatatgct 65880
tgcttataat accctttata tgcaacagtt tgctaacacc gctttatacg aatcttttat 65940
aggaacagca aaccttcgtt cttcggttgt ccaggctgca caggataacg gatatcttcc 66000
tagttctaaa tcagcggcaa aaactaccgt aatgcttacg tgtactcaag cccttaatga 66060
aaaaaatatt cgtattccaa gaggtactaa attcctggct tatgcccgtg atacgtccgc 66120
cgacccatat tcttttgtga caactgataa cgttattgca gtgcgagacg ttaataatca 66180
gtattggcct attgtttctc tggctcaagg acgtattatt cgtaccgaac ttaaatacga 66240
ccctaaaact cctattctta ttcgtgaccc ggatattgat agacaagaag ttaaacttta 66300
tgttgatggc gcagaatgga ttaactggac caataaatca atggttcacg ctggtagcac 66360
ctctaccatt tactatatgc gcgaaaccgt agatggtaat actgaattct tctttggtga 66420
gggtgaagcc gagaaatctg ttgcaggcgg agtattagaa gctaattata tcggcggtct 66480
aaaacctgtt aaagattcta ccattgttat agaatacctt cgtacagatg gcgaagttgc 66540
aaacggtgct gtcgacttca gttatgccga ctccttggct tatattactg tagaaaaaat 66600
tactgaaaac tataacgatg accctgatta tgttggtgcc gatggtgggg gtgaccctga 66660
agatattgaa cgtattcgcg aattggctgt agttaagcgt gaagcccaga tgcgtgctgt 66720
aacaggaacc gactacgata cattcgtgtc cgagcgtttt ggttctattg tacaagcagt 66780
acaaaccttt acagacccaa ataaacccgg ttatgctttt gtcaccatta aacctaaatc 66840
agggttatat ttgacggcag tacaacgtga agacgttcag aactatctaa aagaatttaa 66900
cttagcccct attaccgctt ctgttatttc tcctgattat ttgttcttaa agcataaaat 66960
taaggtatcg tatgccttga ataaattaca ggaatctgaa cagtggctat cggctcaaat 67020
tctttctcag atagaccgtt attatattaa cgaagtagaa atttttaacc atggattcgc 67080
taagtcaaaa atgctgactt atattgataa tgccgaccat agtattttag gctcctctgc 67140
taccataaca atggttcgtg aggtattgaa ctttttcaaa acccctgaat caggtattaa 67200
atactataat caatacacta accgttctgt ggtttctagt gaatttgagt ttgtccctac 67260
tatcgtttct gaagacagtc cggcgtataa tgtcagaatt gccgctacag ataaagacga 67320
acgtggtgat ggtaaaatgg ttattggtcc tttccgtcca ggagatgtaa ttgaaaacca 67380
atatattaaa ccatatacag gaaatgactt tgataaaatg cctgctcctg cggaccaatc 67440
cgtttattac gttataggtg aaattgatta ttattcagat ttcattttct gggacattgc 67500
ggctattggc ttgacctccg atcgttttga agtccaatct attgaacttt atgcaggtcc 67560
tggccaagat aacgtctttg ctaaagacgg tactttaatc gtatttgaag atgacctacg 67620
ccctcaatac actaccattg aattagaacc tattacaata taagcctctt cggaggcttt 67680
gaggagattt aatgtctgta caagcgcctt cagttactag tctgagaatc gataaactct 67740
cggctaacca cgttagcatt ctctgggatg acgtaggcgc caatttctat tatttcgtag 67800
aactggccca aaccaaagat gcaggtgaaa ctatacctga tgataagtta ttttggagaa 67860
acttaggtta taccccggac aataactggt tcgaggaaag atttatatct cctaattcgt 67920
tttataaaat gcgtgtagca gttgcggccc aaggctttga acagtctgaa tgggaataca 67980
ccgaagaatt tgaaacattt tctactaacg catatacctt cgagcatatg cgtgaattta 68040
ctttatccaa taaattcatt gaagaaaaat ttactaaaaa taaccagagt tacgtggatt 68100
ttaatagtga tgccattatg gcttctatga tgaccgaaga ttttacttgg actccggcat 68160
attcacacct ttcttcaatt tccaattatg tattaaaggc cgaccgcttc cacgagattc 68220
aaggaagtat ccaagccgtt tgtaaagacc ctaatcgttc tattttaatg gaacttggtg 68280
gggtgcttta ccttttagaa cgattccaga acacggccaa ggtatctaat gacaaggccc 68340
agaactggca ttatatccgt ttgtttaatg atagagtagg taatccggtt tcacgtacgg 68400
ctcattatca aacagacaca acaacttatg ttctaggtta cgaccgtata ttttacggac 68460
gtaaatcaag tgatattcgt tggtctgctg atgatgtacg ttttagctca caagacgtga 68520
catttgccaa aattggtagt gatatcgacc tggacttcga aatcgaaata tttggttctt 68580
atgcccgttt accattagct atttctacta tcgcagaagc tatgtgtgct tcggatgatt 68640
ttatttacgt tgcggctcgt gacagagttt ataaagcaaa aactactgat gcccctattg 68700
acaccgaccc gggctctcct acttacggtg agaaaatatt tgaaagtggc tattcgacca 68760
taaccggtaa ccctaaagca gtttgttata aattggattc tatccaagga aatacctttg 68820
ccttaattac gggtgaagtt aaagaagaaa gaatggaccc tactaaagaa gaaaacgtgg 68880
ttgattctga atctaaaggt gtttattggt tggatgtcga aactgataca tggacccgag 68940
tatttggtaa tactgaagaa gagagacgtc gtattgagca tgggtatact agcatgtcta 69000
ccgacggcga agaaatattc tttagttcca gtaacttcaa atatgaagta gaagttgata 69060
acgaattacc tttagaatac cctattgtgg cctcagcggt aaaatatgtt aaggatgaac 69120
agtggattca tgataaacac tatctgatga tgagctttag agctaacagt aaatcagatt 69180
ttaaagaatt caaacccggt cgaatggcct attatgctga accgttcttt agttggtcta 69240
gacgcgatgg gacccgttct tggattacca caagtaatca tgcaatggtt gtttataatg 69300
acgcattata tcagaaaatt attgatttaa acagcggttc ttctcctgaa cgtattatcc 69360
gtgaaatttg ggataaaggc ttttgtaccg taacatgccc taatatcgaa ttcaatggat 69420
ttaaaaaata ctcttcaggt ataatgattc acaaatcatc aggtgaattg gttggatatt 69480
tcgagttcga ctaccgagtt cgagatgaag tccgtgttat ttggaagcct aaagaaataa 69540
tgtttacggc tgaacttcaa aaccaagagc atgaaattcc atggacccct aaagaggaaa 69600
ccggtgaaca agaccctgat ttgcgtcctt tattagttaa aatggttcct gatagttatt 69660
tgcttcaaga ttctaacttt gaaaaattct gcgaatatta cctccagttt attagtgatg 69720
gctccggcac ccattataat aatctattaa atcttattcg taaccaatac cctagagaag 69780
aagatgcgtg ggaatactta tggtctgaaa tctataaacg caatatctat ttgtctaaag 69840
aaaaacgcga cgaagtagtt cgtttcttcc aagcaagaca atcggatttc tggtctacaa 69900
aaggtaccga agcttcatat aaattcctgt ttaaattgct ttataacgaa gatgttgaaa 69960
ttgacatcga gtccaagaac tcgattgaat atgatatcat cgtagaatcc gacaatatca 70020
gtgaagatat cgtaggccaa acgatttata cccctacagg aagaagtaat gttacttata 70080
tagaacgaaa ttacaaagat ggtaaattgc aatggcgttt aaccattcac aatcttttag 70140
gccggtttat agttggacaa gagattaaat ctgaacgcac ctcatttaaa ggtatgatag 70200
tgcagggtgt acgcggtaaa gaattgttaa gtaacaatat cgattatatt aaccgtaacc 70260
gttcttatta tgttatgact attaaatcca acctccctac ttctcgatat cgtaatgacg 70320
tgttgagatt tgttcatcct gtaggatttg gttttatagg gattacgttg ctttctatgt 70380
ttgttaatgt tggtttgaca ttaaagcaca cggaaaccat tattaatata cttaagaact 70440
ataagtggga ctcaggtctt ccgtccgagt ggtacgatag agttgctgta atcggatttg 70500
atggtaatat agaaagagac cctagaacag gacttccggt ttataacgtt ggacctaaag 70560
caggcgaacc gttccctatt cctgatgatt atgatgcaga aaatgatttc tctgtattcc 70620
aaggtcaatt acctcatgaa cgtattaaaa agcatagtcc tttatttgac caaagtgcag 70680
taacattttc aaaatggcgt gctttagttg atgaccgact taaagctgat attggaaacc 70740
ctagagaccc gcaagaccca actcaggtaa aaattgatga ttaattcaac agtaatatac 70800
cgttctattg ttacttctaa atttagaacg gaaaagatgt ataactttta cagaacaatc 70860
ggtgatggtg aagaccagaa cacgatgtat gtatctttcg ggagagccca accatgggct 70920
cctaacgaaa acgacccagg ctttgctcca ccttatcctg tagatgattc tgagggcgta 70980
gaagacgtct ggacaaacat gatgggttgt gttaaggttt ataagagtat gttggattgt 71040
gttgttcctc gcaaagactg gggcgatacc tcttatccta accctttcac tttccaaatt 71100
ggtgaaattg tagtggcgaa tagccaacct caaaaccgta ctgatgttgg tgcaggttgg 71160
atggtttatc gttgtgtgga cgtgcctgaa tcaggagcat gttctatttt gtcccttgat 71220
aataaaaccg agtgtattaa acttggtggt aaatggaccg ctaacgttcc ttcagttaaa 71280
gccccggcag gacaaggcga tacggaaggt atggtagaca ctggtgatgg ttacctttgg 71340
gaataccttt atgagattcc acctgatgta agtatcaacc gctgcactaa cgaatatatt 71400
gtggttccat ggccagaaga aattgccgaa gaccctgaac gttggggata cgagaataac 71460
cttacttggc agcaagatga ttatggttta atttatcgta ttaaagccaa tactattcgt 71520
tttaaagcat tcttagattc agtttacttc cctgaattta gtctgcctgg taacaaaggg 71580
tttagacagc tttcgataat ttctaacccg ttagaagcta aagctcatcc atccgatccg 71640
atcattaaag ctgaaaaaga gtactatgat gttatagacc tctcccgcca ttcaggtgaa 71700
atgatttata tggaaaaccg tcctccggtt attcgttcca tggaccaaac agaagaaatt 71760
aacattatct tcgaattcta ataagggccg caaggccctt tcgggggtat aaatacatta 71820
tatcaataat gaggcatacc tatgattaag caaactggta agttactaat tgacgtcggt 71880
gagattggta atgccagcac cggcgacatc ttatatgacg gtggtgttaa actgaacacc 71940
gacttaaaca acatctataa tacttttggc gaccaacgta aaacagccct tacaggcgaa 72000
actactggtc aaaaattaca tgccactgga tactatcaaa aattcggtga taccgaccaa 72060
gcaggttctg ttgatttagg ctctttggtg gatgtcgatg cttctaccgg ttctatagtt 72120
ttaacaactg taaaaggagc tgtgggcgaa ggtattgaaa taattaactc taatggaagt 72180
atttcagcta ccaactatct tgaaatccgt atattggatt cgtttttgaa ccatcctaca 72240
tcaagcttaa gaatagtaac tccttataca cgggttcttt tatggtgtgt aagtgatata 72300
aacggtatag ctgtatggga ttattctatt gagagtatgt ttggtgacaa acgagtgcca 72360
ttaaatagaa catacaacat ttccaacgta cctagagatg tccaggtggt ttattcaggt 72420
caatattctt tagttaagct tttagttacg gcagtaaatg ccaatgaaac cgtttataaa 72480
gcttctgaat atcttttgtt tatggataac caagctaaaa aaatatattc tacggaatac 72540
gctgttatcc gtcgtggaca agccaccgat gaagacgaaa tttacaatct cgattttaaa 72600
tttgatacat ccaactatat agtggctacg gcatcatctg aaacccctat gagattagca 72660
attaaagtcg tagataccca aactattgga gtcccagtat aatgaaacaa gaattaaaaa 72720
taggccaggc cgttgacgat ggctccggag attacctgcg cgcaggtggt ctaaaaatca 72780
ataataactt taatgagtta tattatcaat taggtgatgg agataatcca cacgctgctg 72840
gtgcctggaa acaatattct actgcagacg gtcctttact taatgctgtt atgggtcata 72900
gctatacatt gaatacccaa ggtggaagga ttaacgttca acttcctaaa ggcaccccat 72960
cagaatataa ctttgtaatt cgtttacgtg acgtttattc ttcttggcaa gctaaccctg 73020
tgactattat accggcccca ggtgatacaa ttaaaggttc cgctgtacag gttgaaatag 73080
ctcgtaattt tgctgacctt gaacttgttt actgtgcccc cggacgttgg gaatatgttg 73140
agaacaaaca agttaaccgt atcccaaata acgacctcgc tactgtagca actaaacagt 73200
ttattgccac tgaaggtcaa actgatttct tggatatttt cccaggtcta acctataata 73260
tttcaagtct tagcgttatc caacgtggta acaacttgtt ctacggtgtg gatgatatat 73320
ttgatgaagc tacttctgag tttggtagcc caggcgcaaa cccaggcgaa ttggttgaat 73380
tgaacggtaa agatatccgt ttgaaatatc cttgtgaagc tggcgatacg gtaattatta 73440
aatcgtataa cgatggattg gcccaatggc gtagttctta taatcgtcgc gatattacta 73500
ttttagatac gacccttacc catgaaacca cagttaatgg ttctaaagta gtattagacc 73560
tttctaccgt acagactatt acatcagcag aattaaacgt ttctcctaca agccctatta 73620
accctaatgc ttgtcaggta atgcttaata gtactttatt gcatcaagcc ggtactgcag 73680
gattccctgc tttttattgt gaaggtgttg atacggatga tgcaggcctt tgtgcagatt 73740
caggcggggt atggacccaa tctaaatctg attatatttt gaatatagca gatgatgaca 73800
aaatcgagtc atttgaattt ggacgtaaac tggaacatgg cgatatcctt actgtaattt 73860
ggtataataa cgatatcggt accactatga ctattgacga gattttagat acaacaaacg 73920
atatctatat ttctcaaggt ccttcggtat ctttgactgg ccaggttcgt attactgatg 73980
tagataatcc attttctcct aactttgaac ctgtagcgga atccgaagtt tccattaata 74040
ctgccgcagt gatgtttgat ttgttccacc ctattggaac gatttatgag aacaccgtga 74100
accctaataa ccctgcaact tatatgggta tgggtagttg gaaaagactg tctgatagtt 74160
tccttgtagg ttggtctccg gatgctgact cgttgttcaa tgcaaacaat aatgatttag 74220
actctggtgg tgttcctaaa tctactgccg gcgggacggg cggttctcat aatatttcca 74280
ttaaatatga aaacgttcct gaacttaata cagacgacaa ggtattagtt gccgatgata 74340
acggccctat tgttattggc ggatgtttgg tagacccgga tgcccaaggc ccggcttata 74400
caaaatatcg tgaagataaa gctacgataa acaaacagca atctacaacg cctattccta 74460
ttggcacttt gcctccatat acaaccgttt atcgctgggt gaggattgcg taatgacttt 74520
aacagaaatg aaaagcgggt taaaatcccg ccttgccgac tttttagaat tttcttttac 74580
aactaatcaa cctgccgcag tggcaggtca acgccctatt ggtggtccat cggcaaacca 74640
aacccaaaaa ggtgtttatt accctacggt ccaaagtgct attgatgata ttgctttccg 74700
tgcagaactt cctgtcaatg cagttgtaac tactactgaa aacagggccc ctggctttat 74760
tcagcaatct gataaattaa ctttctccgg ctccatttct tccggtggcg aattaggcga 74820
tacggttatt attaaggtat tcggtttgcc tgttgaagtt attgtgggtg attcttcggt 74880
cctggttgct tctaaagtta acgatgcttt tataagcgct attgctgata gttatatttt 74940
ggcagaaacg tctatcgacc ctctagacca gtctacttta aacattaaat ataacgacta 75000
ccaaaaccat atttttgagc catttaaaca agcaggatgc accatttctc agactatagt 75060
tcaagagcct cgtgcgggtt atggatactg ggaatattta ggttctacta cagaatctat 75120
gacaggtgga accgtaaatg gaacaacaac cttatatcac tataagcgag taagttaatg 75180
tctacaaata cactaaaaca cataagtgat aaatcagaat ttaaaacatt cgaccctacc 75240
gggtcgaatt ttgacccctc tattactaat gtccaggatg cattggcgtc tatttccgct 75300
ataggtgtta caggtaatat accttcggct tctgaaacag aacaaggtat tattagatta 75360
gcgacccaac aagaagttat tgatggtact gatactttct ctgcggtaac tccggccact 75420
ttaaagggtc gtttagatat tcctactcaa gcaacagaaa cttatgtagg tatcacccgt 75480
tatgctacta acgctgaagc cattgccgga acagaaaccc aggctgcaat cgtagcatca 75540
tctttgaaag ctactataga ttatacattc accaatcgtt tagccacaga gaacactaca 75600
ggcgtactca agatttcaac cctgccggct gctctagcgg gtacagacga tacgacggca 75660
atgacaccgc ttaaaaccgc tcaggcaatt ggtgccgcta catccgcgtt gccgacttat 75720
gccagtgcta ctcaaactgt tgaaggtatt gttagaatcg caacaaatgc tgaagtggca 75780
aatggtacat tgaccaacgg tgtagcgatt tctccttccg gattaaaatc tttaacttct 75840
acccaaggac gagctggtat tattagatta gccactccac aagaagcttc ggctggcagc 75900
gattctaata tagctttatc tccttcaact cttctttctc gtactggtac taccggaagg 75960
ttgggtgttg ttaaattatc gaccacggtc ggttctggtg atgggaatac ggcattggca 76020
tataatgcta acgttatttc taccacaggc ggcaccatta atggtacttt aaacgttaac 76080
ggtactttac gtcgcaatgg gcgtgatgtt gttactatcg accaattaaa agattctgtc 76140
cctatcggta ctattgttat gtggggaggc cagattaata atatccctgc aggttgggct 76200
gtttgtgatg gtggtaactc tggtgaacaa gggttccgaa atgtagttgg tagtaaatgg 76260
ggttcaaccg gagcacgtcc tgacttccgt ggattatatc ctagaggtgc aaaccagact 76320
aatgacggcg gattaaaaga atgggacgct aacgtcagaa ttagagatgc taaaggtaat 76380
gatgccaaag gtaaacctaa attaggcgta ggttgtggtt catatggcca tggtactgta 76440
caagcccagc agcttcgttt ccataaacat gcaggtggct ttggtgaaca ggataactcc 76500
ggtgcatttg gtaataccgt tcgttctaac tttgccggca ctcgtaaagg gctggactgg 76560
gataaccgtt cctactttac aaacgaaggg tatgaaattg acggttacgg ttcacgagat 76620
tcaagaacta ctctaaacag tgaagggttg gttggtaacg aaaaccgtcc ttggactatg 76680
tccatcctat tcattattaa agttgcttaa ggaaataaaa tgattgacaa actgagtatt 76740
aaagaacttc cgtttgtcga tggtgtacct gatgcatccc aagagcgtat ccgttggata 76800
cgcaatggcg aatgtattga aggagccacg actaaatacg gtcacgacgg taatttgaat 76860
gcccctgctt taggagtaca aaccaacgta gttagattag aagaaaacag tatagcttct 76920
aaagacaaaa ttaacgagct tgtggataac gttaatttga ttaatgaagc cctagatatt 76980
tctactgata cgggtgttat tcaacaaatt gaaaagaacc gagttgatat actggctgtg 77040
gatgtaaagg cttccgaaac taaacaagaa ttaggtgact taaccgttaa ttttaatttt 77100
ttagaagaag atgtaggtta ttacgacccg tctttagatg gcccatatct caccgtcaga 77160
gaaaatataa atcttcttaa atctgaaatt ggacattatg cgaaccagga tataaacagc 77220
caaccgcttc ctccaggtga aacttctgaa gccaccggca tgaaacgtcg cattatggat 77280
aataccagtg ctattgtcga ccattcacaa cgtatagata cccttgaaaa gaattacgaa 77340
gattctgatg tagggcaact tggtcttaag cttaacgaaa ttcgtgaaga actgggtcct 77400
catattgata ccgtaggtaa acaaccagcg tataccagga tttctgctct tgaaactgct 77460
gctgaaagct ttaacgaatc aatagattct atcaaaacca gtataggttt taataaaggc 77520
cctattgata caagagtaac cacgctggaa actaaaactt ccactttaga aaacactgtt 77580
aataccggtt tggttcctag agttactgca gtggaaaccg ctatcggtac tgctgatgcc 77640
cctacttcta ttaacggtag attaggcggc ttacgcaccg atgttaatga actaaaaact 77700
atagtaggtg ctagttcatc agaagggctt cgtttccagg tttctgatat tgaccgtaaa 77760
atcggtgctg atgtaagtcc ggcggcagga acaattaata agcgtttgaa cgaccttaca 77820
actcaaggta atacctcagc ctctactatt caggacttgc aggccgaaat tggtaataac 77880
caaacgggta ttaaaggttc tattcttaaa attaccaacc aaattgaagg aacaaaccct 77940
aacggtagta ctgtagaaga acgagggtta ataaactctg ttaaaggcct tgaagctcaa 78000
atgcctacta aattgagtga cgcccctgct gatggtaaat tgtacggacg taaagatgcg 78060
gcatgggctg aagttgttga tgcaggtacg gaaatagctg cagtaaaagc ttctttagta 78120
gttactgatg gtgaggttga tgatttagga actcgtttaa ctgcggctga aggtaaaatc 78180
actgcactag aaactgagtt ggctaaacgc cctcctgttg ctcctgtggc tgacggactt 78240
ccgtatgttc tggttgataa cgcatgggta ctattgtcag attttgtgac tttaaaccca 78300
gcaccataat aaaagggctt cggccctttt ttgctataaa tacggttatt agaggaataa 78360
aacatggcaa gcgaatcatt taaccctaag caactcaagg acgctattct gcgccgcctg 78420
ggtgcgccga ttacaaatat tgaagtaact acagaccaag tatacgattg catccagcga 78480
gccctagagc tctacggtga gtaccattat aacgggtata acaaaggcta tcaggctttt 78540
tatatcggtc atgacgatga agaaaaattc cgtaatgggg tatttgacct taaaggccgt 78600
aatatatttg cagtgacaca aattttgaga accaatgtag gttctttaac atctatggac 78660
gggcaagcaa cttatccgtg gtttactgat tttgtattag gcttagcagg tattaatggc 78720
gggttagggt cttcgtgtaa cagtttcgga cctaatgcct tcggtgctga ccttggttat 78780
tttacacaat taatgcaata tcgttctatg atgcaggacc ttttggttcc actacctgat 78840
tattggtata acgatgccac cgaacagttg aaggtaatgg gtaactttgt taaaggtgat 78900
tttattgtaa ttgaagttta tactcgctct tttaatggag tggattctat ggtaggaaat 78960
actgtaggat atggttatgc ttcagcttgt ggtgaagatg catggagccc aggtgctatt 79020
tgggataatc cggcgcgtcg tatttctggt atgcgtgtag gtgaggacct tggtcttcaa 79080
gatggtgcat ataataaccg ttgggttaaa gattatgcta ctgcattggt taaagaagtc 79140
aatggtaata ttttagccaa acaccaaggc atgcaacttg caggtggaac cactgtagat 79200
ggtattcgat tgattgaaga ggctcgttta gaaaaagaac gtcttcgtga agaattagat 79260
ttactcgacc caccaacacc tattttaatt ggataattat ggctactttc gattcgagtt 79320
tattcgctaa gctagaagat aatactggct atgctaacac gaacgaaact gaaataatga 79380
accctttcgt caacttttat aagcatgaga atacccaaac attggctgat gctttagttg 79440
ctgagtctat tcaaatgcgt ggtattgagc tttattatat accacgtgaa tacgttaaac 79500
cagaccagct atttggcgaa gaccttcaga acaaatttac taaagcctgg aagtttgcag 79560
gatatttgga ttcctttgaa ggttattccg gtgacaatac ttatttcagt aagttcggta 79620
tgatggttaa tgatgaagta acaatcacaa ttaaccctaa cctttttaaa catcaatgca 79680
atggcactga acctgtttca ggcgacctga tttattttcc aatggacaat agcctattcg 79740
aaattaactg ggtacaacct tacgacccgt tctatcaagt gggtgctaac gtccaacgtc 79800
gaatcactgc taccaagttc atttacaacg gtgaagaact tcgtcctgaa ttacagagaa 79860
atgaaggtat taatattcct gaattcagtg agcttgattt aatgcctgtt aagaatatcg 79920
acgggttggc tgatatctct gacattcaat acgaagaggt caatgagatt aatgctgaag 79980
cggctgaatt cgtacatcct tatgttgtaa ttaatggacg aggagaggat gttcctccta 80040
cagcatttga tgatgctttt ttagatgatt aaataataca tggcgcatgg tgcgccattt 80100
taggaggttt gatgtttgga cattggtata atagttcgct acgtcgctat attgttttga 80160
tgggtgattt attttcccat gttcaagtgg cgcgtcaaag agaagataca gggcttaaat 80220
ttattaaagt tcctattacg tatgcttcta aagaaagatt tatggcaaat ttgggtaaat 80280
ggactgctgt tcaaaatatt ccaaacccta atatgtctcc taaagaacga gctgaacaaa 80340
aggctaaagt ggaaacagtt ctcccacgta tgaaccttca aatggttgat atgctttata 80400
actcacaata taaaacggct cttcagaata gaacacaaat tcaatttgag aatggagacc 80460
ctcgtaaacg ggttagccaa tattctccta ctccggttaa aatgattttc gaactgggta 80520
tttacactag aacccaagat gatatgttcc aaattgtgga acagattatg ccttatttcc 80580
aacctcactt taatacaaca atcactgaac tctatacaaa cgagattaaa tttgaccgtg 80640
atattcgtat tgtgttccag tctattgcta tggatgaaca acttgaaggt gataccgctt 80700
cacgtcgtcg tttagaatgg tctatgatgt ttgaggttaa cgggtggtta tatcctccgg 80760
ttaaagaaat ggaaggcgaa attaaaacca tttatcttga tttctttgct aactcaaagg 80820
aactcgctcc tgaaggtaat ttcgaatcag ttgatagtga agtggttccg agaggtgtag 80880
aacaaacaga atgggatgga agttccgttc aaacatattc acaagatatt ccagtgcctg 80940
tcgagccagc gcctccagca ccaaggagaa acccatgagc gatttagata tcaataaatt 81000
aatggatatt accgacctcc ctggcctgac cggggaggaa gttacagcct atgaaccaat 81060
agtattaaaa gaagtggaaa gtaatccaca gaaccgtact cctgatttag aagacgacta 81120
ttctgtggtt cgtagaaacc tccattttca acagcaaatg ttaatggatg ccggtaaaat 81180
atttttagaa gttgctaaga acgctgaatc accacgtcat atggaagtat ttgccacatt 81240
aatgggccag atgactacca ctaacaaaga gcttttaaaa cttcataaag aaatgaaaga 81300
tattaccgct gaacaaatcg gtactaaagg tggagagcct aatcaaacta atatccaaaa 81360
tgccactatt tttatgggtt caccaaccga tttaatggat gaagtgggag acgcttatga 81420
ggcccaggaa gaacgtgaga aggtaattaa tggaacaacc agttaacgta ttaagcgatg 81480
accatccact aaacgaaggc aagactacag tcattaagcc gccgggttcg cttgaacgta 81540
aaacagaaga aggtatcaat tggattaaat cccaatggga tgacaaatgg taccctgaaa 81600
agtttagtga ttatttacgt atccataaaa tagttaaaat tcctaataac ggggaccgtc 81660
caaacgaatt ccaaacgttt aaagataaaa tgaataaacg tacccgttat atggggcttc 81720
ctaaccttaa acgagctaat ataaaaactc aatggtctcg tgaaatggtt agtgaatgga 81780
agaaatgtcg tgatgacatt gtctattttg ctgaaactta ttgtgcaatt acacacattg 81840
actatggtac aattaaggtc caacttcgtg attaccagcg tgatatgctt aaaatcatga 81900
gcaagaaccg tatgacgact tgtaacctgt ctcgccagtt aggtaaaaca accgtcgttg 81960
ctatattcct tgcccacttt gtttgcttta acaaagataa ggccgttggt attctggcgc 82020
ataaaggctc gatgtctgcc gaagtacttg accgtaccaa acaagctatt gaattgcttc 82080
cggatttctt acagcctggt atcgtagaat ggaacaaagg ctcaattgag ttggataatg 82140
gtagttctat tggtgcttat gcttcatctc ctgacgccgt gcgtggtaac tccttcgcaa 82200
tgatttatat tgacgaatgt gcgtttatcc ctaactttct agattcatgg ctggctattc 82260
aaccggttat ttcatctggt cgtcgttcca agattattat tacaaccact ccaaatgggt 82320
taaaccactt ctatgatatt tggactgctg cagtagaagg taaatcaggc tttgcaccat 82380
atacggccat ctggaactca gttaaggaac gtctttataa cgatgcagat atatttgacg 82440
atggttggga atggtcctct cagacaatct ctgcgtcctc tttagcgcaa tttagacagg 82500
agcactgtgc agagttccaa ggcacaagtg gtacattgat tagtggtatg aaattggcta 82560
ttatggattg ggtggaagtt actcctgaaa acggatactt ttatcgtttc catgaaccgg 82620
accctacaca caaatatatt gcttcattag actgctcaga gggtcgtgga caggactatc 82680
acgctttaca tattattgac gttacaacgg atgaatggga gcaggttgct gttttgcatt 82740
ctaatgaaat atcccatatg attctccctg acatagtgta taaatatcta atggagtata 82800
atgaggctcc tgtatacatt gaacttaaca gcacaggtgt ctcggttgcc aaatctcttt 82860
atatggacct tgaatacgaa aacgttattt gtgattcgat gcaagattta ggtatgaaac 82920
aaaccagacg aactaaacct gttggctgtt ctacattaaa agaccttatt gaaaaggaca 82980
aattaaaact taatcataag caaacaataa tggaattccg tacctttagt cagaacaagt 83040
tatcttgggc tgcagaagat ggtttccatg atgaccttgt gatgagttta gtgatttttg 83100
cctggttaac gacccagcaa aaatttgccg acttcattga ccgagacgaa atgcgattag 83160
catctgaagt ctttagtcgt gagttggaag atatgaacga agaatataat ccagtcgttt 83220
tcgtggatgc tggcgataat tcatatgaat attcaccgtt gaatcatggt atttcgttta 83280
tataaataac aataaagcat aaccaagagg attcaaaatg tctttattat caccgggcat 83340
tgagctcaaa gaaacgtccg tacagagtac tgtcgttcgt aacgcaacgg gtcgtgcagc 83400
gctggttggt aaattccagt ggggccctgc tttccaggta actcaaatta ctaacgaagt 83460
tgaactggtg gatttgtttg gaggtcctaa caacgaagtg gcagattatt ttatgtctgg 83520
tatgaacttc ctccagtatg gtaatgacct tcgtacagtt cgtgttgtta accgtgaatt 83580
cgctaaaaac gcatctccta ttgcaggcaa tatagaaacc actattacta cggctggttc 83640
taactatgcg gtaggcgata aaattaatat caagcacaac caaaccgttg ttgaatctga 83700
aggtcgtgtg acttctgtag atacggatgg taaaattctt tccgtgttta tcccatcagc 83760
aaaaattatt gcttatgcac gttctcttaa ccaatatcca gaccttgggc ctgcatggac 83820
ggctgaagtt acttccgctt cttctggtgt ttctggtact attaccgtag gtaaaattgt 83880
aaccgattcc ggtattctgt tgactgaagc agagaacagt gaagaagcta ttacttccct 83940
ggaattccaa gcatctctta agaaatttgc tatgccaggc gtagtggccc tttatccagg 84000
cgaaattggt agtactctgg aagttgaaat tgtttctaaa gcggcttatg atgccggttc 84060
tactaaaatg ctggatattt atccaggtgg tggctcccgt gcttctattg ctaaggcggt 84120
atttaattac ggtcctcaaa cagatgacca atatgctatt attgttcgtc gtgatggggc 84180
tatcgtagaa tctgtcgtac tttctaccaa agaaggcgaa aaagacgttt acggtaataa 84240
catttatctt gatgactatt tcgctaaagg tacttccaat tacatctatg caacttctct 84300
gaactggcca aaaggcttca gtggtatcat taatctgatg ggtggtgttt ctgccaacga 84360
taaagttacc gcaggcgatt tgatgcaggg ttgggatttg tttgccgacc gtgaagcact 84420
ccatattaac cttttgattg ctggtgctgt tgctggtgaa ggtgatgaag ttgcttctac 84480
cgtccagaaa cacgttgtta gtattgctga tgaacgtcag gattgcttag cctttatttc 84540
tcctcctaag ggtcttttgg ttaacgttcc attgactcgc gcagtagata accttattga 84600
ctggcgtacc ggtgcaggta ctttcgatgc caacaatatg aacattagca ccacttatgc 84660
tgctattgac ggtaactata aataccagta tgacaaatat aatgacgtaa accgttgggt 84720
gcctctggca gctgatatgg ccggtttgtg tgcacgtact gatgatgttt ctcagccttg 84780
gatgtctcca gctggttata accgtggcca gattcttaac gttctgaaat tggcaattga 84840
acctcgtcaa gctcaacgtg accgcatgta ccaagaagct attaacccag ttgttggttt 84900
tgctggtggt gatggtttcg tattgtttgg tgataagact gcaactaaag ttccatctcc 84960
gatggaccat attaacgttc gccgtctgtt caacatgctt aagaaaaata tcggtgatgc 85020
ctctaaatat aaactgtttg aattgaacga caacttcact cgttcaagct tccgtatgga 85080
agtttctcag tacttagatg gtattaaggc acttggtggg atttatgaag gacgtgtggt 85140
ttgtgatact acagtgaaca cccctgcggt tatcgaccgt aatgagttta ttgctaatat 85200
ctacgttaaa ccttctcgtt ctattaacta catcacgttg aacttcgttg caacgagcac 85260
tggtgctgat tttgatgaat tgattggacc tttagtataa tctattatcc caggctgtaa 85320
tataaagaac ctaaaaccat tataccatga gtttggttac agcgtacatc acgtagaaat 85380
gcgcctggga ttgattattc tctcagaata tgatttatca actgtataac taaaaacgtc 85440
gcaggcgcaa tcctgcgact ttctggtata taaatataag tatgattact aatactctat 85500
ttgaaatacc tataacaaat cgtaacgttt ctgcttttaa aaatcttggc tatcaagtta 85560
aaagtgggag ctcctattta ataaaattag aagactgtcc tggaaaaatt gctgttacgt 85620
gtaaatgtga taaatgtgga atttattata ctgtaacaaa agggcgactt aatgaaacca 85680
attctaagtt ctgtaaagag catcgttggg aagtctattc agaaacaaga aaagaatatt 85740
ggaattctga tgaaggcata aaaatccgta aaactaaagg gcctaaaatt tctaagtcta 85800
aaaaaggtat aaagattgaa gcttgttcag gacctaaaaa cggaagatgg aatcctaaca 85860
aatctgaacg taataaatat tattattcag tgaggtcttt tactaataag acttttaaag 85920
aagaagttga taaactacca aataggcacc taagcgggat atgcggtgtt gaaggggctt 85980
atcaattaga ccatagggta tctatcaaat atggatttga aaatggtgtc tctcccgaaa 86040
taataggaca catttgcaat ctagaaatga ttccttggga aaagaatcgt agtaaagatt 86100
ctaaaaatag tatagattta gatatgctat tccatttaat tgaagaatat gataggaaac 86160
actaacttat ggaacttacg gatatcacta gggccttcga gtcaggtgac tttgcacgtc 86220
ctaacctttt cgaagtggaa attccatttc tcggtaaaaa ctttagcttt aaatgtaaag 86280
cagcacctat gccggcaggc attgtagaaa aagtaccggt tggctacatg aaccgtaaaa 86340
ttaacgtagc tggtgaccgt acgtttgatg attggaccat taccatttat aacgatgatg 86400
cacatgacac tcgtcaagca attgttgatt ggcagaatct ctgtcatggt atgaccaatg 86460
aaattacggg tgcagcacct gcagaatata agaaacaagc agtagttcgc cagttccatc 86520
gtgacggcaa gactgtgacc aaagaagtta caatttacgg cttatggcct actaacgttg 86580
gtgaagtcca gatggattgg gacagtaata acgaggtaga gacatttgaa agcacatttg 86640
ctattgattg gtgggaataa tttttacttt tatagcaaat tatgatagta taaatacatt 86700
caaacaatga agtcaaggag tttagaatgt attgtactta tttaactata tacacggggt 86760
ctaaaatgcc ccgtcgttat atcggctcaa catacgttga aaggattctt gaagaagggt 86820
ataacggttc agtattatcc caagcatata aaaagatttg gaaatcagaa cgtaaagaaa 86880
atccacacct ttttaaaacc cgaattttgt ctttatttga aaccgataaa gaagctcgta 86940
tagctgagaa ggaacttcaa ataaagtata acgtagtcaa atccaaaaac tatataaata 87000
tgtcattagc tcagcctgat gggttctttg gaatgtctcg taaaggatat aaatggtcta 87060
aagaatcttt agataaaagg tctgctacca atacaggtaa aaagaggccg gagcattcca 87120
aagctctaaa aggacgaaaa cgacctggac aagccaaagc tatgtcaggt gaaggtaatc 87180
cgatgtttgg taaagaacat ccggctaaag gcaaaaagat taatcagcca aggatgattt 87240
gccctatctg tggtgttgaa tcaactcgtt cggctataac ccgttatcac aaacacgaaa 87300
atgaatgagt ataaatagaa ttatcaagga gcttcggctc cttatcccat tcatcggaga 87360
ctctaatggc aaactttaat acaatattaa gttttcttaa gccatgggct aatgaagacg 87420
aaaaagaata taaacaacaa attaataaca atttagagtc tgtcaccgca cctaagcttg 87480
atgatggcgc tcgagaaatt gagacacaag agcaaaatat tccttataat gctcttatgc 87540
aacagatgtt tggtagtaat gagcctgaag ttaaaaatac cagggaactt attgatacct 87600
accgtaattt aatgaacaac tatgaagtcg acaacgccgt acaggaaatt gtgtctgacg 87660
ctattgtcta tgaggatgat aaagaagtag ttgcattgaa tttagacggg acagaattta 87720
gtcaagcaat taaagataaa atcttggccg aattcagtga agttttaaac cttttaaatt 87780
tccaacgtaa aggcaccgac catttccaac gctggtatgt agactcaaga attttctttc 87840
ataaaattat aaaccctaaa aaaatgaaag atggcgtaca agagcttcgt cgcttagacc 87900
cacgccaagt ccaatatatt cgtgaaatcg ttacacgtat ggaagacggt gttaaaattg 87960
tagacgggta tcgtgagttt ttcgtttacg acacaggtca tgaaagctat tgcgcagatg 88020
gacgcattta ttcagccggg actaaagtta aaattcctcg tgctgctgtg gtttatgccc 88080
attcaggatt attagattgt tgtggtaaaa acatcattgg ctatttgcaa cgtgctatta 88140
agcctgcaaa ccagcttaaa ttgatggaag atgcaatggt catctaccgt attacccgtg 88200
ctcctgaccg tcgtgtgttt tatatcgata caggtaatat gccttcacgt aaggctgcag 88260
cacaaatgca acatatcatg aacacgatga aaaaccgtgt ggtgtatgat gcttcgacag 88320
gtaaaattaa aaaccaacaa cacaatatgt ccatgactga agactattgg ttgcaacgtc 88380
gtgacggtaa agcggtaaca gaagttgata caatgccagg tgctactggt atgagtgata 88440
tggatgacgt tctttatttc cgcacagcac tttatcgtgc gctgcgtgtt cctgaatcac 88500
gtatccctag cgagtctaat tctggtgtta tgtttgatgc cggtacagca atcactcgtg 88560
acgaattaaa attctctaaa tggattcgtc aactacaaaa caaatttgaa gaaattttcc 88620
tagacccgtt aaaaacaaac ctcattctta aaaagattat tacagaagat gagtgggaaa 88680
aggaaataaa taatattaaa gttacgttta accgtgatag ctatttcagt gaaatgaaag 88740
atgctgaaat catggaacgc agaatcaata tgctaacgat ggctgaacca tttattggta 88800
agtacatttc acatcaaacg gctatgaaag atttcctcca aatgactgac gaagaaatta 88860
atcaagaagc taagcaaatt gaagaagagt ctaaagaggc tcgtttccaa aacccagatg 88920
aagaagaaga ggatttctaa tggaagattt aatcgaagct attaaatcaa acgacctcgt 88980
agcagttcgt aaagcagcag ccccgcttat cgaatctcga gtagccgctt tgattgaagc 89040
ccgtaaagca gaaattgctc gctccgttat gattgaaggc gaagaagctg acgaagatga 89100
cgaagacgaa gataaagacg ataaagcaga taagaaagac aaaaaagaat ctgacgacgc 89160
ggatgatgac gacgaggacg acgaataatg ttccttatcc ctgatgatta cgaattaact 89220
ctagaaagcg tagaggccaa aattccagaa gcacagggac gttttgctgc tctttctgaa 89280
gcgctagaga aaagcgatat aaataatctt gtagagaaca tgattgctga aggcgatatc 89340
gaatatgcta tcgctcttgg ttctttaaat gaatcaatgg ctcttaacga atttatcgtt 89400
aaacacgttt cctctaaagg tgtgcttact cgtactaaag atattaaaac ccgtcaacgt 89460
aacgcattcc aaacgaccgg gttatctaaa gcaaagcgcc gtcagattgc tcgcaaagca 89520
tctaaaacca aacgtgctaa tccatctact caagtgcgtg ctgaacgtaa gcgtaagaaa 89580
gcccgttcta aacgtaaagc ttttggactt aactaatgaa acctgaattg ctcatcgaac 89640
attggggaca accaggtgaa attatcgatg gggttcctat gttggaatct catgatggaa 89700
aaaattctgg gcttgctccc ggcctttata tagaaggcat tttcatgcaa gcagaggtag 89760
ttaaccgtaa taaacgcctt tacccaaaac ctattttgga aaaagccgtt gccgattata 89820
tggcagaaca ggttgctact aaacaagctt taggagaatt aaaccaccca cctcgtgcta 89880
acgttgaccc tatgcaagct gctatcatta ttgaagatat gtggtggaaa ggtaatgatg 89940
tttatggacg tgcacgtatc atcgaaggtg accatggccc aggtgataaa ctagctgcaa 90000
atatccgtgc cggttgggtt cctggtgtta gttctcgtgg tcttggttct ttaaccgaaa 90060
ccaacaaagg atataagcgt gtaaacgaag gttataaatt aaccgtcggt gttgatgcag 90120
tatggggacc atctgctcct gatgcttatg taactccaaa gcaaattaca gaatcacaaa 90180
cggtagaaac cgataccagt gccgatgacg cctttatggc tctcgcagag gccatgaaaa 90240
aagcgttata aatattatta tctaaacaac aggactacaa aatgcttaaa gaacaactga 90300
tcgccgaagc acagaatatt gatgcttccg ttgctcttga cagtattttc gaatcagtta 90360
atatttctcc ggaagcaaaa gaaactttcg gcactgtatt cgaagctacc gtcaagcaac 90420
acgccgtgaa actggctgaa tctcacatcg ctaaaatcgc tgaaaaagcg gaagaagaag 90480
ttgagaagaa taaagaagaa gctgaagaaa aagccgataa gaaaatccaa gaagctgccg 90540
gtcgtttcct tgaccacgtt gctaaagaat ggatggctga aaaccagctg gctgttgata 90600
aaggtattaa agccgaactg ttcgaatcca tgttgatggg tatgaaagaa ctgtttgttg 90660
aacacaatgt ggttgttcca gaagaagcag tagatgttgt tgctgaaatg gaagaagaac 90720
tccaagagca gaaagatgaa accgctcgtc tgttcgaaga agttggtaag cgcgacgcgt 90780
atattaatta cgtacagcgt gaagttgctg ttacggaagc aactaaagac ctgactgaat 90840
ctcaaaaaga aaaagttagt tctctggtag aaggcatgga ttattccgat gcattcggta 90900
aaaaaattgg cgctattgtt gaaatggtta aaggtcagtc tgacgttgaa aacccaatca 90960
ccgaagccgc tataaataaa aatgtagacg atgctgcggc actgaattac atttcagaag 91020
cagttgaaga aaaaggcgct aagcctaccc tgtccttcgc ggacctgtct gcaatcgcag 91080
catcacgaat ttcttaatta ataaggttat acaacacatg aaaaagaatg cattagttca 91140
aaaatggtcc gctctgctgg aaaacgaagc ccttcctgaa atcgtgggtg cttctaaaca 91200
agctatcatc gctaaaattt tcgaaaatca ggaacaagat atcctgactg ccccggaata 91260
ccgtgatgaa aaaatctccg aagcatttgg ttctttcctg accgaagctg aaattggtgg 91320
tgaccacggt tatgatgcta ccaatatcgc agctggccag acttctggtg ctgtaactca 91380
gattgggccg gcagtaatgg gtatggttcg tcgtgctatt cctcatctga ttgcttttga 91440
tatttgtggt gttcagcctc tgaataaccc taccggccag gtatttgccc ttcgtgcagt 91500
ttatggtaaa gaccctatcg ctgctggcgc taaagaagct ttccatccga tgtattctcc 91560
agatgctatg ttctctggtc agggtgctgc tgaatctttc gaagcactgg ctgcaagcaa 91620
agttctggaa gttggtaaaa tttattctca cttcttcgaa gctaccggtg ctgcacactt 91680
ccaggctgtt gaagccgtaa ccgttgatgc tgctgctact gatgccgcta aactggatgc 91740
tgctgttacc gctttgattg aagctggtaa gttggctgaa ttggctgaag gtatggctac 91800
ttctatcgct gaacttcagg aaggctttaa cggttctacc gataacccgt ggaacgaaat 91860
gggcttccgc atcgacaaac aagttatcga agctaaatcc cgtcagctga aagcaagcta 91920
ttctatcgaa ctggcacagg accttcgtgc agtacacggt atggatgcgg atgctgaact 91980
gtccggtatc cttgctaccg aaattatgct cgaaatcaac cgtgaagtta tcgattggat 92040
taactactct gcacaggttg gtaaatctgg tatgaccaac accgttggcg ctaaagctgg 92100
tgtgtttgac ttccaggacc cgattgatat ccgtggtgct cgttgggccg gtgagagctt 92160
taaagccctt ctgttccaga ttgataaaga agcagccgaa atcgctcgtc agaccggtcg 92220
tggtgctggt aacttcatca tcgcttcccg taacgtagtt aacgtactgg ctgcagttga 92280
tacttctgta agttatgcag ctcaaggtct gggtcaaggt ttcaacgttg acacaaccaa 92340
agcagtattt gccggtgttc ttggtggtaa atatcgcgtt tacatcgacc agtatgcacg 92400
ttccgattac ttcaccatcg gttataaagg cgctaacgaa atggacgcag gtatctacta 92460
cgctccgtac gttgcactga ccccgctgcg tggttccgat ccgaagaact tccaaccggt 92520
aatgggcttc aaaactcgtt acggtatcgg tatcaacccg ttcgctgacc cgtctgcaca 92580
ggctcctacc aaacgtattc agagtggtat gcctgacatc gttaacagcc ttggtctgaa 92640
tggttacttt agacgcgtct acgttaaagg aatttaatgc tttaacgtta aaatacataa 92700
ccttatggga gactccggtc tcccattctt gtttctatac tatgcaatct taactcgacg 92760
attgatgata tcacggaagt caatacgatt ttcttggatt ttcagccagt taccagattt 92820
gtctttggta tgggtagagt attcaccgtt ccaccagaag tcagtttcat aggccagggc 92880
ttcgtatttc ttaaccaatg cattaactgc attaccgtta ggattggtac caaatttttc 92940
taccagagct ttgatgtctt tgtcaaggtt agaaagtgta gtacggataa agtttaattt 93000
gttcattttt aatctcctca tgttttgata ggtctatagt aacacgacgc tttttgtgtg 93060
taaaccactt ttataaataa aattatattc tcaataagga aaatagcaat ggctaaaatt 93120
aacgaccttt taaaagagtc gaccactact tcgagttctt cgattggtcg tccaaattta 93180
gtagctttaa ccagagctac gaccaaactg atttataccg accttgtagc tcagcagcgt 93240
actaaccaac ctttggctgc tctatatggt atcaaatatc ttacagaaaa aaacgaatta 93300
tctttccaga caggtgctac ttattctggt gcagtatccg ctaaagaccg tgccactatt 93360
ccagttttca ctgcaggcgc tgtttacgct aaagatgatt tgttccaatt tgaaaacgta 93420
gtttataaag ctttggtagc atcaccattt gcgggtgcta ctggtgatga atacgaacaa 93480
cttcaagaag ctattgttaa attgaccatt cgtattatgt ctgaagccgc actgactgag 93540
cgttttgaag gtcctcaaga agtagatatc tctgaagcca gattcatcgt taataaatgg 93600
aacgctccag ttaaatcccg taagttgaag agtactgtta ctgtagaact ggctcaagac 93660
ctcgaagcaa atggtttcga tgcccctaat ttcttggaag acctcctggc tactgaaatg 93720
gctgatgaaa tcaacaaaga tattcttcag tccctagtta cggtttccaa gcgttataaa 93780
gttgaaggtt tgtgtgatga cggcttaatt gacctgagtt atgctaactc accggaagct 93840
tctcgcaagc tttatgaaat agtttgtgaa atggtttctc atatccagcg cgcaacctct 93900
tatacggcaa cttatgtagt agcgagtact cgtgtagctg ctgttctggc tggttccgga 93960
tggttaagac acaccccaca gaacgacaaa tatctttctg caaatgcata cggattcctg 94020
gaaaatggtt tgcctgtgta ttgtgatacc aacacgccga ttgattatgt tactgtaggt 94080
gttaaagagg aattcggtgg gaaagaagcg gtaggttctt tgttctatgc gccgtataca 94140
gaaggccttg atttggctga ccctgaacat gtaggtacat ttaaagtggt cgttgaccct 94200
gaaagcctgc aaccatctat tgcattaatg gttcgttatg cactggctgc taacccttat 94260
acggttactt ctgatgataa acaagcccgt attattgatg cgactaatat ggatttgatg 94320
gcgggacgtt ctgatatgtc cgtattgctt ggtgtgaaac ttcctaaagt tttgactgaa 94380
ttaaactaac aaaaaaggga ccgtgaggtc cctttgtcgt cttacgacac taattcaatc 94440
catactgctc gtagggtatc ttttacgcac tcaacaagtt gctttttaac ttcaacagga 94500
ttttctgcat cagttaattc taattcttca cgggcagctt cttctaagat atcttggact 94560
gtcaagccca ttacctttcc aaaatccttt ttagatactt cgccaatctt actgatgacg 94620
ttgttaatgc ggttaacagt cacataatcg gtgaattgcc acatcaaatc catatcgtct 94680
tgggataaaa ctacagccgc cttaataggc ttatcagact ttttcttctc gctgaattta 94740
gagttcttgc atttaatcgc tacgcgattt ccgtttggaa gccaggtagg aacatcaggt 94800
ttcaatacaa agccttcagc cgtgaatacc ttaccttcta ccttaggaat aaagtctgtc 94860
gagtttgcaa tagttaggcc agcgttatcc actgcaaaat tataatcagg aataactgaa 94920
tcaaagtcat taggtaattt aataaggtct tcaaagctac cagtagccag acatggagct 94980
accttaaact tatggataat acagaaggct tccatcaatg tatcggttag aacagattct 95040
gaaccatctt ccttagtaac tcggatatcg aacacataaa agtctttatc accgtagtcc 95100
acattcttct ggatacctgt cccagcgaat tcgccataaa tctggtacga ctgataatta 95160
atcgattcaa ttagatgttg aactgattta atagaatcag catagttctt aagtacaatt 95220
tcatagccgt agaaatcttc agcagggagg atagcgccag tgcgcttggc gcatgtgact 95280
gcgtcacgtt ctatgattag actaaagtta gttccatgaa tcttctcacg tgctacccat 95340
tcaccaccag tcaaaccgtt agtacggagt ttttcgataa acttattgtt gtagtggttt 95400
tcgagactgc tatatttctt gaacataaat caccataata aatataatta aatagaagag 95460
ctagtagtct tctgtcacca agccaaatgg tttaacggaa ggacctagac ccattataac 95520
acatctaaat ttaaagcata ttactttgaa ccagaacgcg ctttgcgccg aaccttgttg 95580
ttcaatcttt tacgataaac aaccttttct ttcgctttaa atttgacctt ggcttgttct 95640
acatcaaccc atgctttggc catgtcctta gcagtcccgc ccattttttt agcaatttct 95700
ataaaattca acccagattc gtgtaaaaaa tgtactttaa ccttatccat aacaattctc 95760
tcgttgagtt ggtaaaaccc atcttaacat agaattttta acttgtaaac aggaattttg 95820
tactttaatg caaaatgggc cttgcggccc ttaattaata aacgtaatcg tatataatac 95880
cagcttctaa agcggtgcga tgaataattc gaccattacg agattcttgt acatcaacct 95940
ctggatagtc ggtaatcatt ttttgaagcg tatatcggtg caaataatac gggctatccg 96000
ggttatcagt tttccagtct tgcccagcaa gagtcatttt ctgaatttca tccataaccc 96060
accaaccaca ccagatataa gctgaattgc gtactggcaa tggatgcaca taaggtaatt 96120
cgccatccgg aactggtgcg actttagccg tgactgttac attaccggtt tttgtgacag 96180
tcgccgggtc ataatcagtc gccgaaacca caacagaaac ttcaataacc tgtgaacctt 96240
cagcacttgt atcgattgct agagtatccg tggtgccaac tacaggagaa ccatctttct 96300
tccaagaata ggcaaaagta gcaccagcag gcgcgccgac tacatccgct ttaaaagaag 96360
ctggagtgcc ttccggaaca ttaattgatt ctggggttaa tgtaacagaa acatctgaca 96420
tagttttgtt ctggatagtt aaagtcgtct cagcttcagc agtttccggt tcgccgtccg 96480
ctggtgtggt tgttgcaaca actttaatag tcttgctgcc tgctggacca acagcaacat 96540
aatccattgc agcggtcaca gaagattgag gaacgccatc aacggtccag acaaatgatt 96600
cggtaccttc agctgcagcg ccagcgccgg ttgcagtgaa attggttgtt gctccaataa 96660
cggccgtagc cgccaaagga gcaatagtta cggtataagc cataataaac ccttatttta 96720
aagtgacaaa agatgagtta cgagtttctc gtattagaac agacccatta cgattgatgt 96780
aataaatcaa actgaatagt gtttggtgtg cagtaggatg ttggaaagca gttggacgtt 96840
ctttccaatc cggggtctca gaaatccatt ggtaaatcca ccaaggaacg gtgcaataac 96900
ccgggttctt accgataagc aaaagattag gactgaagtc ttcaggtaaa gagaatacag 96960
gtttttccga ttcaacaacc ttggctacag cctctttgaa tttctcttca acaaatggaa 97020
catcttcttc aataatctct actttaggaa gttcggctac ctcaacgact tcaacaactg 97080
cctcaggagc atcgaacaac agggttgctt cttctttagc aggttcagca ccatcaataa 97140
attcattaga acctgtaagt tcgtcggcgg catcaatcaa atcagaaatg gacaaccctt 97200
cggtttccgg aagtggttcg tcggccaagg ctttaagacc ttcagtgata tcgataatca 97260
aattatcaaa cgaacgggtt ttcttaagtt ttaaaccgaa ctgttcgccg tattcgatta 97320
acttagcttt agcttctttt ttatcttcga gtgcacgaag ctcttcaata tattgagtat 97380
ccataattag tctcttgttg gtgtataaat ataactatat ttataactga gaattactta 97440
tgcaaattca agtacatttt gataatttta gtcatgtccg tattgaatgc gatgaatcta 97500
cattctacga actcagagac tattttagct ttgaagctga tggatataaa ttcaacccta 97560
aatttcgtta tgggcaatgg gatggacgta ttcgtcttct ggattataac cgtaaacttc 97620
cttatggatt ggttcctcaa attaaaaagt tcgccgaaca atttgaatac tctctgtgga 97680
ttgacccacg tattcttgat caggaagata tttctcgtga agattttgat tcatgggtgg 97740
cttctcaaga aatttattca gggtctacca agattgagcc tcattggtat cagaatgaag 97800
ccgtatacaa cggcctgaca aaacgtcgcg caattctgaa tttacctaca tccgcaggta 97860
aatcattaat ccaggcactc ctgagtcgat attacgttga gaactatgaa ggtaaaatcc 97920
ttattttagt tcctactact gcacttgttg accagatgat taacgacttc atcgattatc 97980
gtttgttccc taaagccgca atgcttggaa ttcgttcagg tactgctcgt gattctgatg 98040
caatgattta tgtttcaact tatcagactg ctattaaaca acctaaagaa tggtttgctc 98100
agtttggtat gtttatgaac gatgaatgcc atttggctac aggtaaatct atttctacta 98160
tcatcgaagg cctaaccaac tgtatgttta aattcggttt gtctggttct ttaaaagatg 98220
gtaaagctaa tttaatgcaa tatatgggtt tgtttggtga tgtgtttaag ccagtatcca 98280
cctcccagtt aatggaagaa ggacaggtta ctgaccttaa aatcaacagt atcttccttc 98340
gatatccaga cgaattcact gttaagatga aaggtaaaga ttaccaatca gaaattaagg 98400
tcattactaa ggctactcgt cgtaataaat gggttgctaa tttagctgtt aaactcgcta 98460
agaaagaaga gaacgtattc ctgatgttta aaaacatcga acacggtaaa actctttttg 98520
aaatggttaa agagcaacat aaagaagttt attacgtatc aggtgaagtt aataccgaaa 98580
cgcgtaatgc tctgaaagta atggcggaaa atggtaaggg tattattgta gtggcaagtt 98640
atggtgtgtt ctctactggt atttccgtta agaaccttca ccacgttgta tttgctcacg 98700
gcgtaaaatc taaaatcatt gttctgcaaa caattgggcg tgttctacgt aagcatgaca 98760
gcaaacaagt ggcccaagtc tgggacctcg tggatgatat gggagtccgc cctaaatcta 98820
aagattctaa aaagaaatat gttcatttaa attattgtct gaaacacgga ttggaacgta 98880
tacaacgata cgccgacgag aaatttaatt atgttatgaa agaggtacag ctttgaatta 98940
tcagaaaatt tacgatgatt taatagagaa tgctaggtcc agaggatgga ccaaagccac 99000
tgcgccctgt aaaatcgaaa ttcatcatat tattcctaag tcgataggtg gttccgatga 99060
ccctaacaat ttagttgcat tgactattag ggaacatatt ttaggccata taatcttggc 99120
taaagctcaa ggtggaaaat tatggcgggc cgcatttggt atgacatgcg gtaaaagatt 99180
aaatgagata agctctaggt ctatttccat tttaaaagaa aatgcttcta gattaataag 99240
cgaagccatg attggtaata caaacggttc ttatgaatgg actgatgaac gaagagaaat 99300
acaccgaaaa gctatggcta aagttggatt aacagaagcc aaattaaaag ctttagaaaa 99360
ggcttggacc aaaaataaag gctccaagca atccaaagag actatagcca aaaggtctaa 99420
agcaatgaaa ggatttacac ctattaaagc cggagattat gaaacgtgtt caaaagccgg 99480
caaagccaat aaaggtgtaa agaaatcatt taggtctgag gaccattcta aaaattggca 99540
agctactttg gctaagaaat atccacactg gttaatgtat gatgagctta aagagctttg 99600
gataaataca ggaaagctta aagttggtaa atttacaaaa gaagccatta aagctggtta 99660
tcctaatgtg cattacggta aaatggttac caaatttttc gaggaaacaa aatgaaaacc 99720
tttaaagaag ttattcaaga agcatctatt gaaagcttca tggctaaaat tggttcttgt 99780
cagactatgg acggtctgaa ggaattagag aagtattaca aaactcgtag taaggaagct 99840
gaacttcgtg attcggacga tattagcgtg cgtgatgcat tggctggtaa gagagctgaa 99900
ttagagtcga tggacgacga ggaagaggaa gatttctaaa caaaaaaggc ccaacctttc 99960
ggaagggcca ataaccataa atggctatac acactagact aaagtagtaa ttgggtttcg 100020
ttcagctgct cttcagtgtt ttccgtaacc ggcaagcttt gaacgtaatt ataacatgaa 100080
cccggatgaa ccggaccttt ttctgtttca acaaccaatg cagcatcgat tggagtttta 100140
cagacaacgc aaatcttatc tgacatgatt gtctccttag tttaacttac atatctattt 100200
attacttgct aaagcggcat taatgaattc ttggagaagt ttcattttat cagcatctac 100260
tttaataggt ttaatatttt tggtgcgcct catttttcac ctgcttcaaa tttcctgagc 100320
tccaacatat tctttaatga gaaacctctg gctttgactg cgtctaaagc tgaactacaa 100380
aagtcctgta ataaagccca atactggatt gacgtatcga ttttaattac actagaatct 100440
gcagccatta cagtctttaa ttcagacttc tcatactggt ccatacaaac ctcatcacca 100500
ggctctccac gtcccgtgta gaaatctaat cgcttcttaa gtgaggtctt tttctggatt 100560
tctaatctca ttatttcttt cttacaattc gtatacagtc ttagccattt gctgtgcagc 100620
aaaacgttgt tctgtacttc atactgtaaa cgagttccat caatctttaa atcttcatcc 100680
aaagcatctt gaaacgactc taacttgtac tcaatctctt tactcatcgc atgtttcctg 100740
tgtaataacc ataagaccat tatacactat tcaattgaac agcaattaac cactctgtga 100800
gagctgaatt ctaatttgct ctaatgtatc agggtcatca acgatactaa actgaacggt 100860
cacgataatc gagttatcat cgtacacagg ggtcacacct acggccaggg cagaaattct 100920
aggttcgaag ttccgcacag cggaaactat attacgctta atagtatccg tgattaatgg 100980
ggttatattc tcaaacaatt ggttactgat gtcgcaacca aattccggca taaaagggcg 101040
tgaacctttg cgagtagtaa taatgcctaa caaactattt tttactgcac gagcacctgt 101100
agctttagcg acgtctctat tccaagacgt cctcatttca gggtctaaat ccgaatacat 101160
tttattgata ttcattacat caccttaaag aactctttaa gtccctcaat aacgtggacg 101220
gtatgttcac cacattcaca agaaataggt atggccaaaa taggcttagg ggtaactagt 101280
gcatcataaa cttcttttat atctttttct gttatcacag aataaaggtc atcaagttcc 101340
gcatcgctta aatcggaaag aaaaagcttt tcgcctgcag aagttaaaat ataatcgata 101400
caccctgcga ccatcatagc cctattttta tcttcaaaga gtttagggta cctgaaaaca 101460
attttaaagt tgccaaagtc tttaataaca tcgggctctt tacctaatgt tgcgcgagtt 101520
agtgtcatag ggacaacctg tgagcgacca caactacaaa cccactcacg ttctatattc 101580
acttcagcta atgaatgggc ccacaggttt atcaccagga gctcagattc ttgcttgttt 101640
aaatcacgag catctgtgca attcgaaatg agttcattga taaaggactc tattctgcct 101700
tctaatttag cttggagcaa gtccttatac tctctgaggg taaatgctct gcattttatg 101760
gttttgtttt taatttttac gtcaaaagta taattcattg tcttctcctt taagcttatt 101820
tataaataca tcaataagag gacaccctat ggctaatata gtacgttgtg aaatgcctga 101880
tggagtccac cgatttaaac cttttacagt agctgattat cgtgatttta ttttgattcg 101940
aaatgacatg aataataaat cacctgaaga gcaaaaacaa attttagatg agttactgga 102000
agaatacttc ggtgaatatc ctatgtcatg gcgcccgtat atgttcattg aactttacac 102060
gtcatcgctc ggcaagacca aaattcctat ccgatacact tgcagtaagt gtgaaaagga 102120
tagacaagtt ttattcaatt tgaaacaggc caagttagat aatcccacaa ttgaagtggc 102180
aggcttgaag ctaacattca aatttccgga aatagaatat cccgacaaat ctgaattgat 102240
tttgaacacc ctccaaacag tagaagatga aaacggaaaa tataattgga ctgacctttc 102300
tgaagaagac caattagccg taatagatgc tatagactta tccactttag aggatatagt 102360
caaacaaacc agccctatta atttcgaact caaatatgga tgctgtaatc gtagaacaat 102420
tgcgtatacc gatattttag aggtgtttaa acttatagtc aatccggatg agatattttt 102480
attttaccaa ataaaccatt tattggtaaa gaacaattat tcattagaaa gcattatgca 102540
gatgattcca atcgaacgcg gtattgcttt gtctttggtt gaaaaggacc ttaagaaatg 102600
agttcaaaaa ctatgcaacg tgaaggcttt cctaatatta gtatacgcct ttacgaagat 102660
tatgacgcct ggttagagca tcgttttgtt gaactaggcg cgacatttac tactctaaca 102720
atgcgagatg gactttacgg tagtaatgaa ggattgcttc agttttatga tgcaaagaac 102780
cttcatacta aaatggatgg cgagcagatt atccaaattt ctgttaagaa tgctaactcc 102840
gagcgtaccc agtcaagaat ttatggaagc aaacactttg ccgtaggagt ggattcgaag 102900
ggtgacaata tcataacaat acaactcgcc ccaatccact ttttagagaa ccttaaattt 102960
agtcgtatgt tctttccaag cgtacaagaa acattgacag aaatgattgg cgtaatttat 103020
caagaccgtc ctttacttgc tccaccattg aacgggataa acgtttatgt tcctaatgta 103080
ccatggtgcg attcaatgga ccgttatatg gaatttgttc gtgaagtagg tatggctatc 103140
gaatcagata aattcgtatt tgtatgggaa gatatcgatg ggctttctat tatggactac 103200
gaatttatgg ttaatcaaga gccaattaat tttgtggtag gtgagcctcg tttaataggc 103260
caatacgtcc aagatatgga cactcctatc gcatttgatt ttgaatggtt aactaaagcc 103320
aaccagcatt ccagaaaacc atatgaaaac gctactgtat acgcccactc tttcttagac 103380
aaaaacgcca cacgaattac ttttggtgat gggcaaaaca gtatattggt ttctcgctct 103440
ggtggatatt ctgattatac ctaccgaaac ggatttgaag aagccgatag attagttact 103500
atggcccagt atgatggtta cgctcattgc aaagtatatg ggaactttga attaaccccg 103560
ggtgataaga ttaatttcta tgaccctaaa aaccagttcc aatacgattt ttatgtagac 103620
gaagttattc atgaagtgag taacaataca tcaattacaa acctttatat gtttactaat 103680
ggtaagccta ttaagattga agaaccaccg aaggttaaaa atgaacttaa aactgatact 103740
cccgatcaag aaaataacgc tgggtgataa agagatttct attcctaaat tgggccttaa 103800
acaccagaaa ctggttaaag atgaaaaaga cccttataag gctcttcaca tattaatgaa 103860
ttccatttat aaaggtttat ccgcggcaga gaccgatttt gccgctcttc accttttaga 103920
attcaatgga agattaaaaa gtaaagtaac caaagacggg tttacttata acctaaatga 103980
cctttatatc tgccagcgac ttgaattcca attccaaggt aaaacgttta aatttaaatc 104040
acacgagcca tttcaaacat ttggtcctgt tgatagtgta ttacaatctc tttaccttgg 104100
tgatgacgta ccagattttc tggatatgcc tgcctttgtt gctacatggg ccgacgatat 104160
aacttctact atagctatcc ctggtcctaa tggtcctatc aaaggattgc ttaaaatcat 104220
ggatatctta aatgaagaac gaatctaatc agaatagttt tcgtcgcaat aaactgattg 104280
aagaaatggc tcctcagcgt cgtgctgagg cgctagccca aactcagaac gacgaattag 104340
gaaatatatc agatgtttta tccgattccc aggcggcgtc tgaattgctc tctgaagtgg 104400
ttgagacaaa gtccaatcag attattagtt ctgtagaccg agtagataaa agcgtccaag 104460
atgttgtcgc tggaacagaa ttaacagccg aagccatatc agaacaaacc caacagtcta 104520
aagctctttc ggatgcatta aacgaaaaga ttagtaagct ttctaatatg ttggaggcta 104580
aattttctgg tatttctatt ccaccggaag ggagctcatt aaaggttatt gaagactcta 104640
ttcctgaaga acctaaggct gaaactccta aagttcctgc tgttgttgaa gatattcttc 104700
cgcccgaaga caataaacct gacgccgaat ttatgcctga gcctcctaaa aattcagatg 104760
aaggtaaaga aggtgataag acttctcttt ctgataaaat tgaagccctt actaaaataa 104820
ctgaaaaggg atttaaagct tctataggcg tcgctgatag aatttcaggc atgcttttta 104880
agtataccat tactgccgcc gctgaagctg ctaaactcgc tgcaggttta gttcttttaa 104940
tatttggtat agatgccatt cgtgtatact tccaatattt catggaccaa tttgaatcag 105000
ggtggaaaga atttaacgat aagtttaaag agtggggacc tgtacttgaa ggattaatga 105060
catgggccaa gaacgccgaa gccatgttta gtgaaggaaa ctggttaggt ctggccgaag 105120
ctattattcg cggtatggtt aatcttacta aaaatatggc ccagctttta atgctcggta 105180
tttctaagtt gatttctgct attttaagca aaatacctgg tatgggtgag ttggctgaaa 105240
acgtagaggc ttccgcttta atgtcgtacc aacaaaatac cggagccact ttagatgacg 105300
aagaccaaac taaagtggcc aagtaccatg atagacgttc tgctgaggct ttagaaacag 105360
ccgagaaaat gaataagaag tataaggata aacctgagct tataaaccaa gcagagaaat 105420
acggtaatct tactaaagaa caagctgacc aattacgtgc aggtggaatt gacacaagct 105480
tccgtgacct ccctgaagaa gaacgattag agtatttcaa gaagcgtgat aaagcccaag 105540
ccgatattat tcgtttgact caaactgctg ataatataat gaagcctgat tctaaagata 105600
tcgaaaatgc taaatcattt aaagctgata tcgagaaaca attggccgac cctattatgg 105660
ctaaaggtgg agcaccgaag gaccttaata tccagcaatt acttgataag atgaataaat 105720
ctttagagaa atttaatgaa gctgaaaagc ctaaacctgc ttctgtagcg gaatctcctg 105780
aaaatactca ggttaaaaag gtggatgagc aaatgagagc aaaggaaaat gctaaatata 105840
gtcagcaagc tccaactcaa ataaatcagc aaacgaatat caagaaaacg agtaagacta 105900
gttataattt acctccacag tcttctactc ctgctcctgg tatgcgtcaa gctactaaag 105960
ttaattagga ttaataatga aagcaaaaga acttgacttt gatgtagcct ccttgtttaa 106020
aggaggctca aagacctccg ccggccagtc taaagctaaa ccggcccaaa ctacagtaat 106080
ggcccaatac ccggcagaaa gggcctccgg caatgacacc tctacagata tggtgttaag 106140
cgatttatat aaaaatggct tactttttac ggcgtataat tttagctctc gtgtatcacc 106200
tgatttgcgt aatgaccgat caagtcaaat gactaaaaag ttttcaaaag cctctagtaa 106260
acttaccggt aataccggag gattcagtgc ggttaaaaac ttgttcagta ataactctaa 106320
aggagttaaa tttgacaacc aagctttggc aaatatttta ctcccacgtt ctaaatctga 106380
cgtagattcg gtgtcgcata aatttaatga tgtcggtgaa tcattaatta ctaaaggtgg 106440
cggtactgct acaggtattt taagtaacgt tgcaagtact gctgtatttg gtgcattgga 106500
atctgtaact aacggcgtaa tggctgattc aggtgaacag atatacacca ctgcccgtag 106560
tatgtacgct ggcccggata accgtactaa ggtattcact tgggaaatga ctccacgaaa 106620
cgcccaagac cttatccaga ttattaaaat atacgaaatc tttaattact attcttatgg 106680
tgaaaccggc aactcagcct tcgctggtga attaaaagag aagattgata cctggtatcg 106740
ttctacgttt aaaaaagaag ctattgacaa gtttgacggt aagctattag gggaaagtat 106800
tacaagcttc ctttctaatg ttattgtggt aagtaacccg accatttggt atatccgaaa 106860
ctttggtgat agcagttcat atgatggtcg tgaagatatt tttggcccat gccaaatcca 106920
gagtatccga tttgataaaa ctccggacgg ccattttaac ggattggcta ttgctcctaa 106980
cttaccatct acgtttagtt tagaagttac tttccgtgaa atcattaccc ttaaccgtgg 107040
ctcactttat acggaaggat tctaatgtat actttacaag aatttcagaa ccaggcaatt 107100
aatattgacc tgcagaggaa taacctgttt agtgtggtat ttgctacagt tccttcttct 107160
aaatctcaag cgctcctcga ccagttcggt ggagctttat ttaacaatat cccattgaat 107220
acggatttgt ttggtattac acaaggagag ttgacccaag gtgttacgac attagtgaca 107280
gcgggcactc agaagttgat tcgtaagtca ggcataagta aatatctgat tggagctatg 107340
tcatccaggg ttgtgcagag cttactagga gagtttgaag taggtacata tctgatggat 107400
tttttcaata tggcttatcc tacggcaggt cttttagtcc acgccgttaa aatcccggat 107460
aatactttga actacgaaat ggatttgaac cataactcac ctaacatcaa aattaccgga 107520
agggaatatt ctccattggt attaagcttc cgtatggatt ctgaagctgc taactaccgt 107580
gcttttaatg attgggtcaa tagtgtccaa gaccctatta cacaattaag agcattgcct 107640
gaggatgttg aagccgacat tcaagtcaac cttcattctc gtaatggatt acctcataca 107700
gtagtaatgc ttaatgggtg tgttcctgtt ggtgtttcgt caccggaatt atcctacgac 107760
ggtgataacc aaattgcttc gtttgatgtt acatttgctt atagaagtgt acagacgggt 107820
gcagttggca aacaagctgc ttatgaatgg ttggaagata aagtccttaa aggcgtggcg 107880
ggtataagtg agagcaattc actgagttct tcagtagcta aattaagccg actttcagga 107940
gcttctagtg gattaacagg attggttaat acatttggtg ggcgtgctat taataatgga 108000
atatcgaggt tgttataaca aaaaaggaga gcatacgctc tcctttaggg gtttatttac 108060
ggaacgaaat gaaacctgtt gcagtcatta atggctgctt tttaacaaat accgtaactg 108120
aaataggagc ttcggattcg agttgtcctg tcactacact gttaaaaatg ttttcggttt 108180
gttccggata agaaaaattc tcaacaggtc ggatatcaaa ttgcttatct tcaccgaaaa 108240
ctcggcgtaa ttcattacca atggcactgt caaactcttc agaagcaggg ataacgtttt 108300
caactaccag ttcttgacca ttaaaacgga atgcagattt catattgttc tcctcatgtt 108360
tgtgtaaggt aatagtacca catccatgtg gtgttgtaaa ctacattttg aatttatttg 108420
gtagagcaga gatatccaaa gatgcggcaa ggatttccat agcttcgttg ctttcagaaa 108480
cggattcatt aaccaagaat tgactgaacc catccatcag gcgaacttca ccagtttcca 108540
tcaaatggcc gccatcgtaa acagattcgc tgagctctga aggaggtgtt actgtagctt 108600
ccataaggta tttgtgagat actctatcat tcatggcaaa agccgctact ttatcaacct 108660
tcaacaataa cccgcgcgga aggataattt ctgcttcttc ggcatattct gtaaggtcac 108720
caggagcgat aactttaact gcttcagcac ctcgaataac cataccaatt tcagcaattc 108780
tatctgcagg accttcaggg gcaattggat taccaaactc atcttcttcc cattctacct 108840
cttcgtcatc gacttcaccc acatcagatg aactaccact agccaattta aacaactcat 108900
cagcggagga taaagaacct tcaccaccaa caaaaacggc ttggttgtcg agggccatat 108960
aatttttacc aaattcacca aagatgttag gctttaatga ggctgacaca aagttcttaa 109020
agtaaaatgt tttgttatcg atattatgac gcagaatttt gtatggtaaa tcctgaccac 109080
gatacaaaat agtaccctta ggaagtttaa tacccttagt aaatgctgag tctaaatcct 109140
taatcaattt aatagccgtt gtattgtttt cggattcagg tttacctaaa aggaataagt 109200
tcataggagc atattcagct gcgcaatatt caataatggc attgctttcg tctttggtta 109260
ggtccttagg tttaatgagc tcacctgaat aagcatatgc atcactaata gaatcgttaa 109320
ttagtttata aacggcttcc atagcgaaag caattcgaga ggccttttct gaaggggagc 109380
ctttaaaacg ggtactcagg ttattaacaa ttttcttaat aatatccaga ctattggttg 109440
tattgatttg cgaaaggccg cttaaaagtc tatcgacttc tgtattaaaa aatgccatat 109500
ttttagagta aatttcaaac ccttgtttat ctctattagc ataatttagt ttaaatttac 109560
tatcagtcat taaagcgtga gtgagagcaa tggtgtatct aaagttggca aggtcctcgc 109620
tcttagattt aaactgagaa gcctggcgca ttttggtaat agcacctttt ttaaagttct 109680
gactaatctg ttcaatacct tcgttctcag ggccttcggc agtgtgaacc ggtacagaag 109740
cttcaaactc attataaacc tgcaattctt taggggacaa agtttcaggc tcagcagtag 109800
aatactgtgc ggctgctgcc atacgacggg aaatcttagt acgagtaata acagccttat 109860
cagtacgttt ctcttcaacc ttagcaatac ttgccgagac ggcttcaacc ttacttacag 109920
actgacctgt tttcttagaa acataaactt caccgacttt agaatcgact ttggtataaa 109980
ggtcagcatc aatttcaggc atacccttga tatcttcaat attagcacca cgacgtacta 110040
aaagaacgta ggtatgttta ccactgaatt ggaacatgtc atcaacaact ttaaacttgc 110100
cgccggtacg agccatcgcc aaacgagcta atacgcgctg aacagtagga cccttacctt 110160
tcattttctt ggtagggaaa cggaataaaa ccgcatccat tttaagtttg tttacttgtt 110220
catatacggt atcgaaaatg gtattcagtg taccaagcgg gtcagaacca aggccgccct 110280
taagttcagc cggagcaccc ttgcttgaca aactcattag aataacgtgg acatatttgt 110340
cgcccggctt aaccatttta atagcgtctc cttgagacgc ataagatacc atacgagcaa 110400
ccaggttatc gttacctggc gcttggatag agaaaatctg tggaataccg gaacccggtt 110460
taagatttgt tactggatag ttttttagcg gaatcactat caaaaacttc gtttaaattt 110520
tccattattt acccttgggt gaatttttct gggacattgt aaaggtccat acaagatgct 110580
aaaagaggca acacatcaaa cttagttgat tttacaaatg agtcaaaaga tacaggattt 110640
tcaatagtat caaaatcatc ttgatatgca accaattcgc cggtttccat tagtatgttt 110700
ccatcatata ccactgactc ttgaagctca tctgatgtca taacttcggc ctgaactaat 110760
ttattattag ttttagcagt accgtcatta taagaagcat ctgttatttt attaattttg 110820
agcattaacc cacgtggaag aataatttcc atttcgttgg aaggagcaag acctgcacca 110880
gggaatacca cgtttatttt gtgagcacct gaaatagccc aaccaatacc aacttgatcg 110940
tcattagact taacaagtcc ttcatctgat ttgtctatgg aaacatctaa acggacatca 111000
tcaggcaggg taccgattgc cgcatcagtc atccaagtac cgaaaatatt tggatataaa 111060
gatgtagata caaagtttct gaaatagaat accttgtttt taaccattgc ttcgtaaata 111120
ggtggaatca ttttctgaga acgatacagc gtaattcctt ctggtaatct atcaccattt 111180
ttaaaagcat catctaggtt atcaatagct ttttcgattt ccggggcggt tagaatacta 111240
gaacgaactt ctggattgta tatacccaaa agagcattat tcatatcttc atagcccgag 111300
ccgacatatt cacggatacc acgtttttgt gccggagtat actgagtttc atctcggtta 111360
tcaacaatag agaacattgt ccaacctgcg gctaatgcaa aaccacgaat ttctttttta 111420
atgaccttag tcttagcggc attccaagag ctttcagaaa gttccattgc catagtataa 111480
tctaaattag aatgtttcgc aaagaatttt cctaaccaag cacctttgta ttcttcaaga 111540
acttcgttta atactgaagc aaagctgctt aacgcatcca tagatgttat aggcttacca 111600
tgaatttttt ggaatgcccg aactttaaca tcatggtcaa cttcttttat tttaccttta 111660
gttactattc cactatcagc aaaagcgtcg ccaacaccgt ttatatttgt gactgtatta 111720
agaacacttt ctaaggaaaa tgatgcagta gaaatagtag atagttcatt agattctgga 111780
ataagtggtg cggtagccgg tttacttaat tcagaggcag aagcttcaaa tttagtaaac 111840
ataggagttt caaaacgtgc agattctaag gattgcgaca tagcaatagc acgacgtgaa 111900
atcttagtct tagtaataac agttttatca gtacgacgtt cttcaacctt agcaatacta 111960
ccagcaatag cggtttcttt agtaacctgt acgccttctt ttttacttac ataaacttca 112020
ccgacatcag aatcaaccct agtataaagc tctgagttaa tttctgggat gcccttaatg 112080
tcctcgatat tggcttgttt acgaactaca agaatataag tgtgtttgcc agtgaattca 112140
tacatcgctg gaatgacttt aaaacgtccg ccggttttct gtgctaccaa acgttggata 112200
atacgttgaa cgataggacc ttgtcctttc attttcttag tagggaaacg gaacatcaca 112260
gcgtccatac gaagggcttt aacctgatcg tagacaacac taaagattgt attaattgca 112320
tcaataggag tgggcccaag gccgccttta agttcagccg gagaaccttt agccgataaa 112380
ctcattaaaa tagcatgggc atatttgtca cccattctaa cctgtttaat agcatcgcct 112440
tcagaggcat aggataccat acgcgctact aattgggact ccacgccgcc aatcttccaa 112500
atctggggta ctttaagttt agggttcaag tttactgtag gcagggtgcc ttcggactca 112560
aacacttcat ttaattgttc ggtcataata attcctcttt aataacctta tttatgccat 112620
aaaaggcccg aaggccttta ttaaagtact aacaacgtac ggtacacttc aaatttagga 112680
cccttttcat agcggtcgaa attatcttta aaatcagcga acgcgatttc attttcaaat 112740
tcaaggacaa tttgggacac tgcggtggag acatcgccac cttctttata tccaataacc 112800
acggtttcta aataagcttt catattatag tccagtttga gaccaatcac cgaatacatc 112860
ctcaaatgta tcagcttctg ttttatcgaa acgccaacct ttaataattg gaaggaaaat 112920
acctacagta tcggtacgtc ctttagaatg aacccaacca ttacattcac agtcagcaat 112980
acggccaatc aacttgcctt cacgagcttg tttcataaga agttcacggt ctaaatcagg 113040
acggtcttcc aatggaatca ataccttttt acctgattta tctttcttat gggtggtatc 113100
tttaaagcct gagccacagt cacttgtaat tcgacggcaa cgtgatacta attcaacacc 113160
gccaagtttg ttagggtcct tagagtgttc ataataacct accacttcta aagcgatatc 113220
gattacttct ttgaacttga taagattctt agaacggcgg ttttcccagt aggagtccat 113280
gttcttaagg ataatacctt ccagaccttg gtcgacatat ttcttataaa cgactttagc 113340
ttcttcaaga ttattaaccc actggttttc gatagcttca acacgcgttg tgccatgcaa 113400
tacgacatta tgagccacca taagttctaa ggccgcaaag cgtacatcat acttatcgcc 113460
tttaatttta ccttcggaat atacgacatc cagtggaaca taatcccacg cctgtaatac 113520
catacctgct gcttcggttg gagtaatagt tccttgaaga gccttgttag ccaagccgtt 113580
tgacgtggaa cgatcggcga cagtttggaa ttccttagcc ttacttaatt caggaagttc 113640
ctcatcaaac atactaaaca aatcattgga tgctttaggt tctaccttag gagtatggta 113700
aactaattcg ccgtcaatca taacaccatt aggatgacgt tgtcgggctt cttcggtcat 113760
gaccatcaat tcagcagcca aaagattaag cccttgatat tcgttaccac cacgagtaag 113820
gaatgtcaca ccatcgttac gaacttcggc aaaacaacga gccccatcag cttttaattg 113880
agcaaacgct ggccatttaa tatttttctt aatcaaatct tcatcataag aactagccaa 113940
catctgtggt tgttcaggga ttaaaccttt ccaaaccttg ttagcaatag aaattgatgc 114000
accacattca aggtcacgca tcattacacg acgtaatacc tcggcatccg gggccttagc 114060
atcagcaatg atttgagcca gttcttcaat agccgcatta cccgtaatct tacgtgtggc 114120
taatgtgaat tcagcgaaat caagaaggtc ttcaagagta atcataccaa aggattgaga 114180
tataaatcca ggttctggcc actttttaat accgtagttc agacgacggg tataagccat 114240
acgataaaca cgtttcagaa gctcattgtc cttttcacga gcaataatgg cttctttagc 114300
tttagtagaa tcgatagcag caatttcgtt caagatatct aaaatcataa tcacctcatt 114360
agtcatggat tctattataa gccacatcag ccaaaagcaa gtctaatcgc ttatgataag 114420
agaacacaaa tctcattcgc ccatcggatt tgaacttgga cataaagtgg acataaatga 114480
atccctgttc gacgcattcg cgccaaacag gatggtcttt agccggattt acatcaaatg 114540
agtaatcatg attcacatga cgaataaact ggtttacatg accataatcc attgtagtgg 114600
taggaccata gtctgaaatt gtatgaacta caaacatatt aacctcgcgc aatccattca 114660
actgcggcat tattacgaag ggattcgatt gctgctatat cgtcccatga attaaccttt 114720
acggccaaat taggtttaaa gtcacgttca ccacgagcta accaataaac ttggatatcc 114780
atgagaacat tagatgcggc atcacagtga tgagccaaat catcaacata aaacttaata 114840
cgtttgccgt acgtattttt agctctaatg aacaagtctt cttttgattc tgaatgtcca 114900
cacatcagaa tctccttgaa tgcgccaggg aacaatgcat tcaaattgaa ttgtctattc 114960
agcagggcat caattgagtc gcctagcgca gtcacggcta caaaatcgaa gtcttttttg 115020
agcctgttga tgtgttttaa tgcgtccatg taaggagaca gataacgaat aaaatctgac 115080
tgattatatt tctcgattaa acgagcgcct aattcgttgt cacaattaaa cagctcacca 115140
ggagataaga aacgttcgtc ctgaatcata ttcaaaatat gttctaaagg caaattatat 115200
ttctgtgcga aataaggcaa gccagactgc caacttaaac atactccatc gatatctgtt 115260
aagataactg gtttcataat aaatctctca atttgtttag gatgtcgata aactcttttt 115320
cagttagtat tgtatcacat tctgtaaggt ggcttgccat agaatgcttt aaaaccctac 115380
cttttgtgga ttgtaacgca tcgcgaaatc ctttgttttg gagcgctgct tcaaaatacg 115440
cactttcgta aagctctttc catgcttcgg aatatcttga aaacggagtt ccaacccaga 115500
acaacgtgcc acggtcctga gctctagcat aagctcgtcc agctttttgc gcgtccaacc 115560
cggacatccc aaatatacgt ctttgttgtt catgattttt caccttacac ccttggagga 115620
acccttcgag accaccaaat tggataccat ccataacgaa aggccattta gcaaagttac 115680
ttaatgcgca tgatggccat gggaaattgc ttctgatttc taattcagac atctttgaca 115740
cttataattt caacatcagc ccaatgacca taaccaggta gacggtcttt aatagacaat 115800
ccaccgtcag atttcagcat tttaattgtt ttagtatatg gttcaatatt tcgggcccat 115860
ggactcacgt ctgttacacg ataagtaact tcaaccattt ctgttcccaa aattttctga 115920
atcagtttct taaacatatt atcctcgctt taaacatttg attacagaca gttcaccgcc 115980
catacgaaca tcttcagttc catcgaccca taggacggtg taggcttctt taatagtaac 116040
attacctaat ttaaaagcag gtagaacctt tgaaatcatg ccaggaatac ctataccttt 116100
taactggact gtttgtgata agaatagttg cattagaacc tcatctgaaa gccatgtgat 116160
ttaacattac caccatagat gtcggacgta ttgacttcac gtgcagagct tgggtcgata 116220
ttgatatcat ggttgagctt agtgattgct agggtatcac gaccattaac agtacggaat 116280
tctaccgggc atacaacatc ggcgtaagcc ttaatagatt cacgagtggg ttgtttgtcg 116340
gcaggaacgt ctttacctgc tttagagaaa acaacttcac agaaattttt acgagtatca 116400
aaataagtgg tcataaacat aatattttcc tcaaaggagg ccgaagcctc catttttaag 116460
attagatatc gaattcgttc agaactacat caaagattgc ttccaggtgt tcaggtttag 116520
ctcggttgct caggatgtga cgaatccagg ttttaaccag aagcttacga ttaacgccgt 116580
tccagcaagg atgggtacct aaatcacgtt gacggaaatc atcatctaaa gcgattttaa 116640
aagtagaacc ttccattgtg attgaaaccg taatgccgtt ttcaaagcgc atataaacgt 116700
agttaggagt catgcactgc tcgatttcgc acactgtacc gttgttgtgt ttccacaggc 116760
aaataacttc agaagaacca gcgataccgt tagaaacata tttacgttcg aagttgatgt 116820
agttcatttt attctccagt ttgttttcgt attatttggt acaggtctat aataacacaa 116880
cctgtaccaa agtaaaacat ttatttcaca acattccaat ttttcatatc aagtttacca 116940
acttttttca tctgagcaat cagacgttca gcacgtgtac gggcattaac gtaatagaat 117000
tcaccaattt tgttttcttc aatacgaccg gtaattacag ttttcagttc ataaatccaa 117060
cctgtaaaga agttgtgaag ctcgatggtg aatgtgaaat cagtacccat accttcagtg 117120
gtttcgactt cgatgatatc accttcaact gcagtcagga cccacatggt ttcttgatat 117180
tcaccgttga aacatttagc tttaacagat gcattaagat ttacagtttt cattttattc 117240
tccagtttgt tttcgtatta tttggtacat gtctatagta tcatgcctac tggagatgta 117300
catacttttt tgcaaataaa acgaaaaaag gaacccgaag gttccttact taatgatgat 117360
acgaggatta agctctgccg tgtagtaatt tacagcctta gtaactatag cttcaccttt 117420
aggatttgcc agaacccatt cacgggctcg tttgtgagct tctaattcag tcaataatcc 117480
ggacctttga caccctctgt cttgggtacc tgcttctgtt aaaaaagcaa ctaggtaaat 117540
cgcgttttca taaggcttgg cgggcggtac gtatactggc gggttatatg ccgcgggatg 117600
atgtgccgga attccatcat acggccctat acctggcacc gcgtaagagg caccgcgcgg 117660
agaagtaaat gtatgattat atctatcgtt cataatattt cctacaaaaa tgggactccg 117720
aagagtccca taacttatgc ctgaggctta ccaaagcaag cagcatctgc acgtagtaca 117780
gcacgagcac gagcttgaag tttttcaacc aactgattga tacgtgcgtt agactcacgc 117840
ttgtagccag cgcgtttaga ggtaccatca attactttaa cttctttctt agccattttt 117900
aaattctctt aaattagaat gaaggactta ttgacattgc cttcgcaagc cctctatggg 117960
gtacttaggt ttcggatatt taacgacagg ataaccataa acctcgtcaa cattcaagag 118020
gtacaccgta aaattgtcgg ggcggtactt ctaaaacata ccgattcgta aatcgataat 118080
cagacaattc gacggctcct cgattttact tcagggtaat aataaaatga cgtactgctt 118140
tacgagctgc tgaagccaaa ggcttagcaa atttcagttc atctttagct tccagttcag 118200
cagccagagt agcctgagcc ggattcagat gtttgaaata acgcaggatt tccagtgctt 118260
cggcttcaac atcaatagag gcgccgtagt tttcgtgacc gttgttccaa gcgttgcgtt 118320
gcagttcaag agcgtgattc agttgtttgt tcattttagt ttctcaattc gagataaaga 118380
ttggtggaca cgttcgtctc agtattccag ctgagttgta tctcgccgta tggaagaggc 118440
taaccccata caccaaccga agttctgtat gacatcaacc tcttcgtaat tttatttata 118500
caagcaagga attgctttat agtggcaggt aacgaatttt tgtttaattt ctttaggctg 118560
tttaataccc aatgcaacta aaggatgagg cacgttagca atcttaccaa caggaagtgg 118620
agtcaaatcg cctacttcac aaaaaccttc agggacatca ggtcctacag aataaatttc 118680
acaaagttca gggatttcac cttgatgaag tttgccaata acgataccag atgcagtagt 118740
ttcttcatca ccagcttgtt ttggttcgga aacgagaata acatattctc cgaccgcttt 118800
aataggaagt tccatattta atccatattg ttttgttgat agattaataa taacacgcta 118860
ttcttaaagc atattatagg acaagcagag tttcggtctg aaggccatta acagaaatca 118920
gcttatcgaa acggaatgaa cgccaatcat taaccttggt atcaaatact ctgatataat 118980
taacaggttc tttattggct tcaggtccag gggcctggac ttctttatat ggaagcaggt 119040
ctaagtcacg tgtacaagtc atacgacggg cactaccatc agctttttca aacaggactt 119100
cgtgagtacc tacagacaaa atagtcttga ctttttcacg gagacgaatt gtttcttgtt 119160
cagttaaaat cataattatt ccagaatagt tttgatagtg gttgcattac gctcttttag 119220
agctcttaat aggctatggc aattttcaag aataggtact gttttgtagt tcatgttggc 119280
ataaacccac tcagatttat agtacgattt ccatcgagag aaaaagtact ttttatattc 119340
tactgaatag gccaccaggt tttcaccttt tgagttcaga cctgaaaact taactagacg 119400
aaatttcatt attcaccaca atagttttga attgattccc agttcaaaga acggagacct 119460
gtacgattat actggataac ttcgatgcct gattcacgga ggatatcgtc ccacccttca 119520
ggatttcggt catagagctc agcataaacc aatgttttaa ttccagactg cgcaatagac 119580
ttagcacaat cagcgcacgg agataatgtc acgtacatcg tagcgccatc aatagaactt 119640
ccggtacgag cagcaaacaa aatggcattc agttcagcat ggatttcatt tttagatgac 119700
catgcagcgt gagccatacg gtgttcttta agaagaacag atttatgcga cattcgagcc 119760
gggtcataca caacacgagt ccagttctgt tccacagcat ggtcacaaca gttaacacca 119820
ccagaaggcg aaccgttata ccctgtagaa ataatgcggc cattcttttc aataaccgcg 119880
cccactttcc atgaacaaca ttttgattct tgagaaatca gatatgcaat ctgaagatat 119940
gtgcttgctt tcattctacg tacactcgct gtgcttcgac caaaccatct gaaccgagtt 120000
tcaactgggt aatttggtcg ccatttttag gattaacgat aaccaatacc gcgcgtggag 120060
attcctgaat tactcgcaga gttgcatcag gaaaacgtac agaaacctta ttaatcaggg 120120
cctgagcaaa ttctttaact ttaacgtgaa actgctctac agtaataggt tgttcgctca 120180
gcattagatt gtctccaact taagttgttt ggtagtggta gcttgggtaa cgtcgccttt 120240
aacaatataa cacacttgtt ggaacgaact ggtcaaaagc tcttcagcct gacgatcggc 120300
ttgttccttt gtgttatggc gagaatgaac ttcaatctta ccatttttaa caataagcac 120360
tttccaatcg gccggagttt taataggttt gatttcaggg ttctggaaaa ctaactgcag 120420
ttctttaggg tctaccactt cgataaagta ttcgaattca tggctaaaaa agcccgctga 120480
attaaaaaga acactatttg catcgtcagg attacccgtg attttgctca ggtcgacaaa 120540
catcatctcg tcatatacac gaattcggct tacacgttca tgaccattat gataatcaat 120600
ttcaacttca aacggattca tacccacata cttagcaaaa gctgtattga ggccataagc 120660
accgttatta gtgaatttgt ttttggtgta ttcaccaacg aacttgtaaa acttacgctc 120720
ttcaaagaac ttacccattt cgatttcctc atttgtttcg gtaaggtcat catatcaccg 120780
tccttggtga aagtaaacac ctttttttaa atagcttcga caactaccgt ttgtttctgg 120840
aagtccattt tgcatgaaat agccaaaatg tggttatcaa ttttaaatgg aacgattgca 120900
aatgctgcac cgggcgtgag ttgaacagtg attgcatcaa ctgcatccgg gaacatgatt 120960
tccagaatag cagacaaacg accatgtacc tttagttcag tcgacgtgtc gacgctttcg 121020
tatagataat cagatacaat ctgactaaaa actactttaa caatttcaga ataagtaggg 121080
aacataatta cctcagtgta cagtatggac tttaacgtta acaataaacc ggtcaacgac 121140
ttcagtcaga ggaacaaact caacatagta ctcgcctttg taacgttcat tgaggtcatt 121200
acgaagggcc gcaagtgagt taatgagggc aggagacata ttcagaccta ccagtttctg 121260
aagctcttta taagcttctt cttcaacttc atggtgtttg ttatacataa tgttcttcca 121320
agaaggcaag gagttcagga gcggatttaa aaataccacc atcgaccttg tcttcatctt 121380
tatagtccat aacatccagg ccaatacgtc catcagttaa aggccatacg ccgaagaaaa 121440
agcatttacg tttttcaatt tcttcgattg tacgaaaaat cttttcgata ttattcatta 121500
aaagtcaccc gctgcgactt gccaacattc aacaccaatg cgccgccaca tttccactac 121560
ttgggtacgg tcatcaatag ctaatttaac atcaaagtgt ggagcaattt tttcccagaa 121620
gatttcttct ttaacgatgt catctttacg gtcgtcacct tgttcgcgtt gacattgcat 121680
gaccaatggt acaccagcaa agtcctcaac ccatttgcga gtcatacgat aatatttcat 121740
tgggtcttct tcagtgccac attcgcgacc gcttactacg ataatctgat aacccatatg 121800
ggcatacatc ttagacagtt caactaccat tgggttgatg acgtcagtat cacacttctc 121860
aaggtcgtat ggactacggt ccgccatttt ggctagtgta ccatcaacgt caaaaataac 121920
ggctttaggt ttgccaggag tccctgtata aaccggaagt ccaagataag cccgcatatg 121980
actatacatg gaacgcagaa cgtcaatagg tactgctttt gaaccacggc gactgttacg 122040
tttaaccagt tcagtccaag gaacatcgaa tactttatat tcaacttccc agccatattc 122100
tttagcaaag gttttccaca tcaaacgacg ttcaggattc aagttggtgt ctgaaataat 122160
tacgccctta acagaatcac caccatacaa aatactctta gcagcatcga actgcatgca 122220
agtcacgatg ccttctttct tcttggagta tttgtattca tcacgggctt catgacccat 122280
gattgattgg cgatagtcat cacggttgat gttaaaataa ccagggttct tagcaatgaa 122340
ttcacgagtc catgtgctct taccagaacc agggcaacct acagtcagaa taattttctt 122400
catcatttaa ttcccaacag agttttgagg agctgaatgc gtaattcaac acgcccttta 122460
tttaattcag ctactgcctt gttgcttgac ttgcgacggg tattggcaga gatgaacata 122520
attaaatggt tctttagctc acccatatcc acaccttggg ccttagcagc cttccgcaga 122580
gccttgcctg catcatctaa ggcttttgca gggtcttcgt cattcaagac caatccgcgg 122640
tctaaatcca tatatacagc gccatggcat gaatcaatat aattgtcgga gcacttgata 122700
taattctcta ataactcttt catacaccga gttccttata aagttcttca cggcaagttt 122760
taagagtttt acctgattcg taagcaacac tttcaggaac atcgccaagg gttactgcgg 122820
attgcatttg accatggcgt ttagccgcat attcaaaact tttcactagc tcacgaatac 122880
gttctttttc attgtattct tcaatgaatt cagggtattc ccaaaccgga cgcatcatac 122940
gataccattg ttggatggtg atataattac ttccatccag attaataatt tgcgaaggct 123000
taatagaccc tggagcataa aaagttacct gtcttactac atcaataccg tccaccatag 123060
cccaagcaaa atcgaaagtt gccttctttt caagtggtgt acttgcacag gaccctagct 123120
taaggagttt ttgtaatgca ggagatttaa cgcctgaaat gtactcagga ttagccacaa 123180
aactgttatc gcgtaaagtc ataataattt cctcaaattt tataatccgt aggagcatta 123240
tactctgctc ccaagagttt gtaaactact ttccaaaaag accatcaata cacatactga 123300
acgcaatccc gaagcaaaag aatgcgatag ctaatctaac ggcatcccaa ccaagactac 123360
actcaatcat ttgcacttct cctcttttag tccggaacgg taataacata acatagattt 123420
ctggtcttgt acatatcttt ttacgtcatt caaccaaata cgatgttctt gggaatcttc 123480
aaatggcatt ccaacccaag ctttaccatc gattacctta acctgccatt taacattatg 123540
ttcggcaata ggttgtggcc atgaaggatg cagttgttgc ttaggcacta caggaagctc 123600
ctgagcacat ccggctaata agccaataga taatactact acagataatt taatcattct 123660
gtaatgctcc tgaagtcttc tgtaaaggaa tcgaaggact tgttgatttg tttttcgacc 123720
agtcctggct tacttgccac cacgtgcgcc ttcttcgaat ctttacggag cttttcattt 123780
tctaccttaa ttttatccat tcgggcattc atttcagtag tacggaattc aatatcagag 123840
tattgaccac gaaggtcatc tacggcttcg gcattctgtt tagccgtttg ctgggtagtt 123900
ttcagttctt cagtaagggt atcaatacgg cttgattgat acgaaataaa accgtaagca 123960
cctactgcaa tggctccagc taaaaggtaa atacttaatt tagacatttg gtaataatct 124020
cgatgatgtc atcacgtgac agggaattaa taagaaccgt tttaggattt tcgcactgaa 124080
ttttgtacgt ttcgaacata aaacacaatt cttcagcggt atggtaagga cttgaaatgc 124140
caaggcgatt aaacttgtcg cttaatgggt cgcaaatcaa atagaaagtg atgcctgaga 124200
ttttgacatt aggttggcta atattaatga atacctcggc atcgtacttg gaaaggttgt 124260
tttggagaaa ctcaaccata gagttgacag cttcaggcat ggcttcacgc ttttcttctg 124320
cataacgggt agagtattct ttttgcttga ttttcttttt agcattttta gctaaagtac 124380
cacgaagatc ggtcaggtaa cctacggcac gagaaccttt aaaaacttgg ataccgtcag 124440
tagagtcacc aaaagcctta acaaccattt cgttagtaat catttgcata ttcattttgt 124500
tttctcctca ttagttggta agtctatact aacacaacat gaggagatgt aaactactct 124560
accacaattt ctttcaaata tttttcaggg atttgggctt tatggttttt caagaacaca 124620
gagttaatct ggtctacaac cgtatcataa ttaataccgc ctacgtacgc ctgcataaga 124680
atagagaaca accctgggaa gtccttaagg attagctgtc cagtaacggc gtagtcttta 124740
cggtcgcgtc ccttgagttg ggaatacgct gcttccaaca aagccagtga ttgttctaga 124800
taatctaaat gaatacgttc aaaggcatcg attttctcta tagcaaacga atccgtactg 124860
aacaggccac gaaggtcgtc agttccacca gccactacaa cttcaaacaa acgttcgtta 124920
ttgttaatgg aatctttggt atgatgcagc gcactgtacc aagcggtttt gagtttaaag 124980
aacgtaccat ctttcagtac aaagatgaaa ccttcaatac cctcttgttt acggatgttt 125040
tctacgaaat caccttcaga gagttcatag cttttaacca aatgcttacg cagtgcgccg 125100
tccttaaaca gttcggcgta tggaatatat tcacctgttt cattattacg aacgttcaac 125160
aggatgaggt ttgtttcttg gtaagccaga acgatacggt tagtaggagc gacgtactca 125220
aggttgcatg tatatcctgc tttagtaatt tcttctaaac gggcagcgaa ggcctcgttt 125280
tcagggagac gaaggaaacg taaagaatca tgtaccattg atgaatggat agagccttta 125340
gatttaacag aaagatattg tctgtccatg aaggtagaaa tcaaggaacc atcttcctta 125400
gccattacga ggtcaatatt ttccggcgac aaatccagac cgatagtcat agggttttcg 125460
tcaaggttaa agaacttttg cataggacga gcagcaatac gtactggacc gttctcgtcc 125520
atttcaaaca taatgcctcg acactctagt gcgccgtcct ccaaccaatc actgtatgat 125580
gcatagttat aactaaagat gcgatagttg actcctagcg cactctgaaa gtctttaaag 125640
aagaacttag atttagtcga gtttttaacc agggccatca agttatcata taattcaatc 125700
attgcttatc cttttaatcg gtgttgggta ttccaaggtg gattaaattt ctttatgaac 125760
attggctctt caagagacat ggtctcaact gacatagttc caagttcgtt agtcattgac 125820
agattaaagc actgccgtgc atagaactct acctttttac ctgccattaa tgcttcatga 125880
atcagaatgg acttagtcga atctgacgtt tggtccttac gattaatagc ggttcggtag 125940
tagttgatgc gcttacgaag atttttagtc ttcccgacgt agactagtat atcatcaacc 126000
gctatagcat atatgacatt ttgtttattt ggtactgtga gtggagctat ggtggcgtca 126060
tcttggagtt ctagggtgac gtacttgata aagctaaatt cgtctgcgat ttctttcata 126120
gcaataaggg gccgaagccc cattccttaa aaatatctct tgtacgatgc cattactttt 126180
tcatcgacat cgttatcaat ttgtgctaca aggtaagaac tgatttccac ttcctgagga 126240
gcagcctgta cagcatcaga attcaggtat tcgcgaatcc aaggatacgg atggcgagta 126300
ggagcatcag taataggaca tggtaagccg cattgtttca tacgagaaac cgtcaggtaa 126360
tcgacaaaag cacccatgtt ctgagtattt aatccagggc aagtaccatc tttgaacagg 126420
tgagcggccc attctttttc ttgacggtta acttccatga aaatatcaac tgcttcttgt 126480
tcgcactctt gggcaatttt aacccattca tcgccatcag taccaagttg aagttgacga 126540
ataatgtact gagtaccttt aaggtggagc tgctcatcgc gtgcaatgaa cttcataatc 126600
ttggcattac cttccatgat ttccatgttc ttatggaagt taaaggtgca tgcgaaagat 126660
acgtaaaaac gaatagcttc caaggcgttg attacgtgca ggcagaggta aagagaacgc 126720
attagttcat atttggcagt tttaacacct tcactgaact catggtattc ttctaaagca 126780
ttttggtatt tacgtgtttt ctcaataaca tcgtcgtaat aacgaccaat ggattcggcc 126840
cgtttcatga tagcgtcatc taacagaatt tcatcaaata ccttcgatgg gtctgtatag 126900
aggttgcgca tgatatgagt atatgaacga gagtgaatgg tttcactaaa tgtccatgta 126960
gccacccatg tatcaaggct agggtccgaa atcaatgctt ggagtgcagc agaaggggcc 127020
cgtccttgga tactgtccag aagtgattga tacttcaggt tattggtaaa aatattttgt 127080
tggaattgtg gaagcttatt aaactgcgcg gcatccatca tcaagttaac ttcttctggg 127140
cgccagaaga aactcaactg cttttcacaa agctcttcga atactttatg gcgttggata 127200
tcgtaacgag caatacccaa tcctgaacca aagaacatag gttctgttaa aacatcaact 127260
ggggtggtat taaaaactgt agacatatta ttctcatttg ttagtgactc atccatgagt 127320
caattataat cagagtttct taaagcttac aagctgcaca atcatcggct ttaggggttt 127380
cgatttcata gtcatcggta ccggagccat cacgggtatt atgataatag agattttttc 127440
cgccataata ccagaaatat agcaggtcgt caagcattac agacatcgga acttttcctt 127500
ttggaaaaat ctgtgggtca taatacgtgt tagctgatgc agattggcat acccatttca 127560
acataatcgc cacttgggta agataaggtt tattaccttt cttagcgagg gtccaagcat 127620
aatcatacag cccttggtta tgttctacat taggaactac ctgacggaag ttaccttctt 127680
tagattcttt aatacttacc gggccacgcg gaggttcgat accgtttgta gagttggaaa 127740
cctggctgct tgattcgcat ggcataagtg ctgataatgt gctattacgg atgccatgtt 127800
tagccaagtc ttcccgcaac gacgtccagt cacaaacgta ttttggagct gcgatttggt 127860
caattttttt attgtaccag tcgataggta attcgcctcg agaccattta gtgtctgaat 127920
aatactcgca aggtcctttt tcttcggcca gcttgattga tgctcggata agtccatatt 127980
gtaatctctc aaacagttca tgagttaaat cgttagcgtc ttcataagaa gcaaagtttg 128040
aagccaacca agcggcgtag ttcgtaacac ctacacccag gttacgacgt ttcttagcct 128100
tcagagcttc aggaacagga taatcttggt agtccaacag gttatcaagt gcacgtacct 128160
ggacttcagc aagttcgttg attttgtctt ggtcttgcca atcgaagtta tccagcacaa 128220
atgcagacaa cgtacacaat ccgatttcag cgtccgggct attcacatca gtagtcggga 128280
tagcaatttc acaacacaag ttgctctggc gaataggagc tttctcacga ataaatggtg 128340
tgaagttgtt agtgttatca acgaattgag gataaattcg tgcagtgcct gaacgttcag 128400
tcatgaacaa ttcaaaaagg tcacgtgcct taatacgttt cttacgaata ctagggtctt 128460
tttctgcagc ttcatacaat tcacggaaac ggtcttggtc ttcgaaataa gaatggtaaa 128520
gctcaccact catttcatga ggactaaaca gagtaatgta atcatttttg ccgaaacgtt 128580
ccatcatcag gtcgttcaac tggattccgt agtccatatg acggatacgg ttctcatcga 128640
cacccttgtt gtttttcaga acgagcagat tttcaacttc caaatgccaa ataggataat 128700
aagcagtagc agcgccgcca cggattccac cttgtgaaca tgatttaaca gcagtctgga 128760
aatgtttcca gaacggaata acaccagtat gtttgacttc acccatgcca atacgagaac 128820
cttcagcacg aatcatacca acgttgatgc caatacctgc acgtttagaa atgtattcaa 128880
ttattgagtt agcagttttg ttaatagatt tcagtgagtc gcctgcttca ataaccacac 128940
aagaactaaa ttgacgggtt ggtgtacgag cccctgccat aataggcgta ggcaacgaaa 129000
cctgacgagt acttacagca tcataaaaac ggatgatatg agctaaacga ttaccaggtt 129060
cttcttggtg caacgccata ccaatacaca taatagcgaa ctgaggagtt tcgtagattt 129120
taccggttgt tttatcttta accagatatt tctctttaag ctgcatcgca cctgcatatg 129180
tcaattcaaa gtcacgttca tgcttgatat gagattctaa gaaagtaatt tcttctgcag 129240
aatatcgaga cagcaattca gggtcatatt taccttcgtt aacacaatag gaaatatggt 129300
cgataaaact acgcggttca aactggccgt aaacttcttt acgaagagca aacatcaatt 129360
gctttgcagc aacgtattgg taatcaggct cttcaaccga aataaggttg gctgcgacct 129420
taacagtcag attctggata tctttggtag tcataccatc acgaagatga gatttgattt 129480
cttcgtataa ttcatagggg tcgatttggg ttccttcaca gccccaagtc agaactttaa 129540
taattttttg tgcgtcaaaa tcttgggata caccactact tttttgtact tgcataattt 129600
cctcaatatg ttaggttcta caattattct atcatagaac ctgttaagca tggactgata 129660
tttatagaat gaaattcagt ccgaccataa taaccaaaaa cagagtacag attatttgaa 129720
ttttcatata gccatcttag ccttaatagt agggtgtgat tcgtaacctt taaggacgaa 129780
atctttaggt ctaagtttaa gaacatattc caattgttct ttagtagaaa gatggcggaa 129840
tttataaggc aatccaccta ttaccagttc acaaagctct ttaggttcac ggcgcaatac 129900
ttcctggcat tgttcaacat ggttggaata gatgtgcgta ttgccgcctg agaacactaa 129960
atcacctgga ataagattac acatcttagc tacgatatgc acaagagcgg cgtaagaggc 130020
gatattaaat ggtaatccta agaacacgtc aacagaacgt tggtaccact ggaggtcaag 130080
gtgaccatta cgaacgttga actgataaaa acagtggcat ggtggaagag ccatcttatt 130140
aatttctgct gggttccatg ctgatacgat ttgacgacgg tcattaggca ttttcttaat 130200
gcgttcgaca atctctacaa cctggtcgat accaccaaaa tctcgccatt gtttcccgta 130260
cacaggaccc agttcgccat cagaatatcc caaatcaatt gcttgatttt catagttttc 130320
gtcccaaata gttttacctt cagtacgcga gccatgagta cgttctctga ggtcattaac 130380
attagtcgaa cctgacaaga accaaaggag ctcagcaata caggctttcc atgctaattt 130440
tttagttgtt accgctggga agcctttagt taaatcaaaa cgtaatttag taccgaacag 130500
ggcaattgta ccagtgccag tacggtcgtc agtttcgtag ccattttcca ggatatcttt 130560
aattaaaaat tggtattgtt tcatttgtat actgtttccg tcagtgtagt aagttcgtct 130620
attttatacc aatgggtttc aagcatttca cgttgacgaa tttcatgaag gaagttttct 130680
tccaattgaa ccgtagagtt aacccgatgg catttctcaa tacgagaaac aactacttca 130740
tcagcataag gcaatgctgc atataacaga gcagggccgc cgattatgct tactttagag 130800
cttggtccaa gcataggttc aaagaacgta ttaggacttg atacttggat ttcaccacct 130860
gtaataaagg ttacgtactg cgcccatgtg atatagaaat gagcgaaatc accatcttta 130920
gtttcaggat aatcacggtc aaggtcacaa actacaatat gactacgtcc agggagtaat 130980
ccaggcaatg attggaatgt cttagcaccc ataatcatga ttgtgtcttc agtacgtgct 131040
ttaaaattct gaaggtcctt tttaacccgt ccccatggaa gtccatcacc tagtccaaat 131100
gcattttggt cgataccatc aactgttttg gttggagaat aagcgaacac taatttaatc 131160
ataatttcct cacgctttct tagcgatttt ccagtctgct ttaaattggt caacatcaga 131220
gtggtgaatc cagaaaccag atgagctacc atcttcataa agaggacaac catcacactc 131280
atctttccaa cccatcgcac acaaagcctg ttcagctttt tctagagctt ccggattatt 131340
accttggatt gtgaagtacc atttgccttt aacttcagaa tcgttgattg attcacgttg 131400
taatttcatt ttattctcct caagttgaca aggctatagt atcactacca tagcctgagg 131460
taaacttatt tttgaatcaa gcccatataa aattcagcat cttcggcatg cataccgtca 131520
caatactcgt cagccataaa gcgggtaagg tcttcaagag gaccttggac ttcaatttgc 131580
atactacaga attgcgtatc tttaatatag gtcataacta aagaaggata acgattacgg 131640
ataacttcat aagtgtattc aaaatcaacg atatcgatat taaccttagc cattttattt 131700
tcctcactcg ttagttgata ggtctatagt atcatgttta aaggcattgt aaaccattaa 131760
atgccaaaaa agggaagacc gaagtcttcc cattataaat caataactta tagaccagct 131820
aacaggtcgt ccagaccatc gtcatcagaa ggacttactg acggctcagg agtagtggaa 131880
cgagttggtg tagacggttt ggaatcatat gcatcaaggt ctgcactgaa tgcgtccagg 131940
tcatcaccaa tcttgtcagc ggctgcagaa gctttagcgg cagcaccacc aagagcagct 132000
gtaccaacaa ctttcttaaa cttggcttcg ttagtttcga atgatttgaa atcaagcagt 132060
ttagaaaggt cgtgcatttc ttccatcaat ttagcttggt aagcttcatc attgatgtta 132120
ggaatttcag actgacccat gaatttggaa tcgtcgtagt tcttgaagtc gccaactttc 132180
ttagatttca gtacgaagtt cgcaccatca aacggacatg ttacgtcaac cggcacttca 132240
ccaatatcag tatcaacttc aaccatctgg ttgattttat ccataatttt ctgaccgaaa 132300
cggaatttaa acactttacc ttcgttagca ggcactgcac tatccttaat aacaaggatg 132360
ttagcccaga aggaagtttt acgtttcatc agtttgtatt cggcattatt agtattaaag 132420
gtatcattct ggttcatgta tttacataca ggacatgaat cgaaatcgcc gtgagtagac 132480
gtacatgatt caatatacca ttgaccattt ttcttaaagc cgtggttaac aagtttaata 132540
aatggcgatg ggttagcttc gtttttcgaa ggaaggaatc taataaccgc tgtcccgaca 132600
ccattgtcat ctttcaattt ccactctgat ttatcatcgg aagagaaaga actaccacct 132660
ttaagggcat taagttgggc ggcaagctga gaagggtcac gacgtttgaa catagacata 132720
ttatttacct tatttgatat atttaattaa tttattaaca gttggtgtta tcacatgtac 132780
cttgataact aggttttgtt gatgaagtaa ttatatacta cttcatgtta agcattttaa 132840
tttaataaac tcagggtctt cgttaggaat ccatccttta ttaaattgtt taatcatact 132900
tttagctgtt gtttcactaa cagaaatacc agaacctata agacgacgcc aaccgcacgt 132960
tcttccttgt gaatttatta taatatattt attataagca atatcactaa gtttccaatc 133020
attaggattt gctctggaag ttttccaagg gcgataatca ggttgattca tgtaattaga 133080
agctttcata ttagctctaa cttcagggcg tttagccgga tgggtatgtc caaagactcc 133140
aaatcctccg ccggtgtaaa ctaaattaaa ataatcatcg ttatctctag cttgaacttt 133200
caattgttca gaacgttcaa tattgataac aatatcaaat ggcgttatag ccaaaatttc 133260
gactataggc ttttcttctt caatggctct tttaaatctg ggttgttcgc aagaagtcca 133320
atactcttta cctttacaat caaacattac accattttca aaagtacaat tagttttaga 133380
acctatatac aaaaatggtt taatgttatc actttgcctc ttaggccata tcattttata 133440
tactatattc aaaatttaca acccttaatt gtttcaatga acaatttacg agcttctaaa 133500
ttatcgatta taaggatttt cttataagca tttaatttag tcgaatactt agaccacact 133560
aaatcgttgg tctgttcatc atgtttattt attatatcca taaatgaatc aagcaaaata 133620
aacgtttcga atgaaataac attcgactga aggagcttaa aaatatagct cgagttaact 133680
tttttattat aatcaaaaat ttcagaaagc gcttgaactt ccactttctt actaaaataa 133740
taaatgtttt ttatatcatc ctcaaaaact tgttttattc ttttaagtct accgatatat 133800
tctcggtaaa agactaaggc gtcagcatca ctgatgtcgc caatccatgc gtcttggtta 133860
gccaccaagt tactcatgaa gataagagca agctctttca aagtgtattt atcactcaat 133920
ttctcaaaga aatatttgtc acgacgtttt tgataagccg tatcggagat tcgcatgacc 133980
cagttatatt ttataacgtc gtatttggcg ttgaagtgat gtttgagcat taagtatagt 134040
gaatatacgc tcttaccatt caccatacgg ttattgtttg gtggcatgcg aatcttaatc 134100
ataacaagaa atccagggta ttagtctttt gcgttcgggc cattgaaggt cgaagcaagt 134160
tatcatcaat ggcttcgttc ataattttat caataattcc tgcaggcaaa taacgagcaa 134220
agttaccttc agggatgctg ttctcttcca accatgcggt agccgcttcg aggtaactac 134280
aaccttcagc ttcaacaaag gcctcaatat caaggccgtt ctgttgtttg tttaccaata 134340
catggacagg ttcggaagcg gtattaaccg ctccatcaaa atcattcaaa gattgtgtca 134400
tacagttcta ccacttcagt tttttcgtct tcgaaacgtt cacgagtgcc tttatggtac 134460
agggagaaca gttggttaaa cattttaccg tctacaccaa gttcagtctt agcacggtct 134520
ttgatatctt taatttcgtc accgtaagct tccattttta atttagtatc ggaagccgac 134580
ttaatcaact gagcaagggt attgccatgt tcttcttgat tgaattcaac tttcactttt 134640
tctttagcca ttatattcac cttaatagaa atcagctact gtagcggtta gtttagacaa 134700
accagattta acgaaataag gataaacttt agatttcgaa ggtttgttat acgtattata 134760
tctttcagta attaaagcaa caatatcatc tggaataaag tccatatcga ttaagatttg 134820
gttttcacag aaacgttcat attgttcttc agtaagaagt gttttaatta tatcatggtc 134880
ataataatta agagcaattg cttcaagttc cttggcacga gtgctaggag tacgttcgcc 134940
ttcaaccatt gtcaaccagt aatcaccacg aactttaata ctcgcgacgt tatctttacg 135000
gtcaccttta accactttag ttacacaatc cagtaatgag tcaccggttt ttgttttaac 135060
gaattttttc tgcattggag accattgctt aacgccaggg aatttatgga gttgagtaaa 135120
gtcaccgtcc gaagaaccaa tcattaccgg atggcctaaa gccgtaagga tacgagtcaa 135180
tacagcaata tggtcatctg cctcgacagt atcgatgttc ataacaatat aaggcatgtt 135240
atgttcgagc tcatcaataa tcaaatgcat tgctgtgaat aaaccttccc aatcaaataa 135300
tgattcttca cgagccttgg cacggttttt cttataataa gaagaataac gacgacgcca 135360
ataacctgat ttagagttat cgacacaaat gattaattgg ttgtaacctt gttttttaaa 135420
gtctttaata tttttcttaa ttgaattcaa cacgaggtgt cgaagcattg ctgtagttac 135480
tttaggaaat ccggcatttt caccaaattc ttggaatgcc gcagccataa tgatttggct 135540
aaagtctaac aacaagaatc catctttttg acgttcttct tcaggaagta aaaaatctaa 135600
atcgttcata tgaacctctg tccaattagt gtagaggttc attatatcat gaccctagaa 135660
gaagtaaaca ctttgctata aatagttcta taccctgaaa acgaaaagga aataaaatgg 135720
ctgatatttt aaaacctgca ttccgtgcta catccggact cgatgctgcg ggcgagaaag 135780
ttatcaatgt tgccaaagcc gattacaatg tattagatga tggcgtcaac gttgaattct 135840
ttatagatga gaacaccatc caggcgtacg acgagacgcg cggatataag aaagggtttg 135900
cagtaatcca tgaccaacgt atctgggttg ctcaacgtga tatcgatgcc cctgcaggaa 135960
cttttactcc gggctattgg actgctaccc gtaccgaccc taaatggatt accgtagcgt 136020
ctcctacacg ccagctggct tccggtgaat atattgcagt agattctgct gctagcttta 136080
ctacatttac cctgcctcct aaccctacag atggcgatac cgttgtaatt aaagatattg 136140
gtggacgtgt tggttataac gaaatcaagg tccaatctag ttctgctcct ggtggtggta 136200
accagaaaat tgttcgtttt ggtaatcagt ttactgagac cttaattaca aagccttttt 136260
cttataacat gattatcttt gctaaccgtc tttggcattt ctgggaagca ggtaatgaag 136320
aacgcggtat tcgggtagaa ccgaacatgg cccagttcca atcacaagca ggtgataacg 136380
ttctccgtcg ttatacttca ggtgcagtaa ttaagtttac tcttcctaag tatgcgaacc 136440
aaggcgatat gattaaaacc gttgatattg atggtttagg aagtaagttc cacttaatcg 136500
ttgaaacgtt tgatgcttca tcttcattag gtaagcttgg tcagcatagc atggaattcc 136560
gtacctccgg tgatggattc tttgtttata actctaccga aaaattatgg tatgtttggg 136620
acggtgaccg tcaaactcgt ttacgcgtaa ttcgtgacga tgttgagctc ttggctaatg 136680
aaagtgttat tgtttttggt cctaataata cgacgccgca gacgattaat atcacattac 136740
ctacaggtgt agcccagggt gatgtcgtta agattgctct gaactatctc cgtaaagctc 136800
agacggtaaa tattaaggct gctgtaggag ataaaatagc ttcttcggtt caattgctcc 136860
agttccctaa acgttcagaa tatccgccgg atactgaatg ggtattgaat gatgtattga 136920
ccttcaatgg taacttaagt tatactccgg ttattgaact gagttatatt gaagacacca 136980
ctacaggtgg caaatattgg gttgttgctc agaacgttcc tactgtagaa cgtgtggatt 137040
ctaaggatga tttaactcgc gctcgcttgg gtgttattgc tctggcgtca cagacccaag 137100
caaacgtaga ccatgaaaat aatcctgaaa aagaactggc tattactcca cagactttag 137160
ctaatcgtgt agctactgaa tcacgtcgtg gtattgctcg tattgctaca accgctcagg 137220
taaaccagaa tactggattt gcattccagg acgatttgat tatttctcct aagaaattaa 137280
acgaacgtac cgctaccgaa actcgtcgtg gtgtcgctga aattgctacg caacaggaaa 137340
ctgatgcagg tgttgatgat acaaccatta tcactcctaa gaagctacag acgcgccagg 137400
gaactgaaaa cctgtctggt atagtaaaat acgtatccac cacgggaacc actcctgcga 137460
cttctagagc aactgtaggt actaacgttt ataataagaa cacaactact ttagttattt 137520
ctcctaaagc tttggaccaa tataaagcta actatgagaa ccaaggcgct gtatatcttg 137580
ctacgcaagc cgaagttaat gcgggtgcta ctaacccagg ttttagtaac tcagttgtta 137640
cacctgaaac attaggtgct cgtcgtgcta ctgatactaa tcacggttta attgaaattg 137700
ctacgcaaca ggaaactgat gctggaactg attatactcg tgcggtaacg cctaagacgt 137760
taaatgatag gaatgctact caaacactta ctggtattgc tcgtattggt actcaagtag 137820
aatttgatgc aggtgtatta gataatgtta tttcaactcc gttgaaagtt aaaacaagat 137880
ttaatgatac tgctagaact tctgtctcag cagccagtgg tttgattgaa tcaggaacct 137940
tatggaacca ttatacacta gatatccgtg aagcaagtaa tactcaacgt ggtacggctc 138000
gtttggctac ccaaactgaa gttaatactg gtattgatga caaaacaatc atcactccac 138060
ttaagcttca agctaaaaag gctaccgaaa acgctgaagg tattatccaa ctcgctactc 138120
aggctgaagt tattgctggt acggtaagta ataaagcgtt tagtcctaag cattacaaat 138180
atatcgtcca acaggaaaaa tcctgggaag ctacttctgc tcgtagagga tatgttaaat 138240
taaccacagg tacagccact tgggaaggtg acgatactaa tggttctgtt gccaacctgg 138300
ctaaatttga agattccggc tttgctattt ctcctcttca aatgaatacg gcattaactc 138360
actatcttcc gattaatggt aaggcttttg attccgataa attagatgga tttgatagca 138420
cgcagtttat tcgtcgtgat atagcacaag atattaatgc taatatgaca tttaaacagc 138480
ctgtaagaat tgaaaacact ttagcggtta ccggtgcggt taatttgagt ggttctgtta 138540
cttcaaataa tactacgtta accggtgcta ctgcaatcaa tagcaattct actgtaggcg 138600
ctttgaatta cattgagttc acttcacttt cgcaaggctc gggtacttgg atctctcaac 138660
atgatagcaa tgttaaagct cctgtatttt taaatataac tactccagcc ggcgcatcta 138720
gatacgttcc tttaattaag caacgttata aagatggaac atttaccttt ggtacattga 138780
taaatgaacc tacctcaaat gatgaaggtg cttttattct tcattatata gatgcagtaa 138840
aaacccagag caaatggacc tttagacgga atggtgattt agaaataact gcaggtaatt 138900
tcgttcttgg taatgggact gctgtaatta atggtggtct taatgttact aaagcatctg 138960
gtattactac tacaggattg gttgcttccg ctgcatcaag atttgatggt agtgttgcaa 139020
ttaataatac attaactgtt cgagaccctt tgacagctaa tggtggttta acagttaact 139080
cgagaattcg ttcacagggt actaaacctg ccgaccttta ttcgagaaaa cctaatgcag 139140
ataataccgg tttctggtcc gttgacgtta atgattcagc cacatataac cagttcccag 139200
gttattttaa aatggttgaa aaaactaacg aagtaacagg actgccgtat ttggttcgtg 139260
gtgaagaagt taaatcgcct ggtacgttaa ctcagttcgg taacactctg aattcacttt 139320
accaagattg gattacctat ccaaatactg cagacggaag cactactcgt tggactcgta 139380
cttggcagca aaataaaaat gcttggtctg gatttgttca ggtatttgat ggcggtaacc 139440
caccacaacc atctgatata ggtgctttgc cttctgacaa cgcttcaatg agtaacttga 139500
ccattcgtga ttggttaaga attggtaacg tacgtattgt tccggacccg gtaactcgtt 139560
ctgttaaatt cgaatggatt gatacaccat aagaggtaat atggaaagat ttatggctga 139620
atttggacaa gattacgttc aaattcctgt actatctgaa aataatgccg ttagttataa 139680
acttagtata gcaggaagct gtactaagtc cactaaaaag gcttatatca aatttcaaga 139740
tgaggacttc ggtcctcaga atttccaatc tggcctaaat ttggttgaaa tagacccgac 139800
aaataacaca atagtgacta caaaatcata cgcatttacc aaagaccatg atgttatttc 139860
ccaagcgttt ataacttata tttcgtctat acctgctggt agaattgttt gctttatttc 139920
ttccggtaaa ttaaacgcct cacaggtatt aattgattgg tttagggctt ctggctctac 139980
agcatttcca gataaatggc tcattgataa agtggatact tcttattcag ctttttatgt 140040
ttcaggaaga aatgctattg taatggaaca tgtgctttat aacgacggcg ttttggtaga 140100
agacgtttcc accccattag aagtcgttta tgacaacttt aatgatgtag gaggaaccgg 140160
gttccctgtt agagtcattg aagatgaaac cacttattat agtggagcta ctcaagaaat 140220
taaaaggttt cctgccgaat ccaccataac tccttgtgct ggttataata tggttcctgg 140280
agatttcttt tatctcaaat tccaaatgac ctacgaccag gctttaaaag atttagggac 140340
aacccagatg tccatacgat tttttaatgg ccaggaaatg attcaatcca ctgatatcaa 140400
tattcctgta ggagcgggct ctccaccagc aggcgcatgg atgtcttttg agcgcgtaat 140460
agaagttccg ccgaatgcta atggttttac attatattgt agaaaaactg tctcaggcgg 140520
agtaggaggt gttaggaatg ttatgtttgg tgaaatagct agacctgaag atactcctaa 140580
atccgctgaa attggtgtta atggtattcg tatgagctat ggcaccgaaa cccgttcaat 140640
gggtaatgtt attgcacaat tgaatgacaa atcatccggt aacgcaggta aggtgtttgt 140700
tcaagagttt aaagaaaaat attaagggac cgtaaggtcc ctttttgcta taaatacgtt 140760
atctaataaa gaggaataac tatggctgat ttaaaattag gctcaaccgc tggaggttcc 140820
gttatatggc accaaggtaa ctttccgctg acgccagtat caaatgatat tttatataag 140880
acctacaaaa tctatactga atttaataag cctcaagctg cagataatga ctttgtttct 140940
aaagctaatg gtgggaatta tttaggtaca gtaaactttg ataaagacct acaatttaaa 141000
gattctgatg gatactgggt taaattaggt agaaaaacca atacaacccc aatgtcatcc 141060
acatattctt tctcattcag aatgagtaaa ggcatgggtc ttgaaacagc tgatggggtc 141120
ccgtttgtaa ttttcgaccc gactactgtt gtaggtgcaa accgacttac tgtaatgggt 141180
gatatccttg gtcgacagat taaagatgaa tctggaagag tgttttctcc agggaatacc 141240
ccgacaaaag cccaagtcgg attaagtgat gtggataacg caaaacaggt ccaaataaat 141300
aatagtaaca tacaatctat ggctggcgtt ctttcagccc cgaatttcat atctaggaac 141360
ccaggtacat tgaacgaaca cgttcctcgt attgaccagg ttgttcttag aggtacatct 141420
gaagattttg gatattatta agaggcatta tggctacttt aaaatcgata caatttaaaa 141480
gaagtaaaac accaggagcc aagcctactg cagctcagtt agatgaaggc gaactggcta 141540
ttaacttgcg tgaccgcact atttttacta aatcagacca gggacagatt atcgatttgg 141600
gctttgcaaa aggcggacaa gttgatggcg atgttaatat taacgggacc ctgaatttaa 141660
atggtcctga aattgttgcc tccggtggtt atatagaatt taactatcgt acgacaggta 141720
gtggctcttg ggcgggtcag cacaatgcca aagctcctat ttttgctgat ttaagtgcgg 141780
ctgcatctac ttcagaatac aacccactga ttaaacaacg ctttaaagat ggaacatttt 141840
cagcaggtac actagtaagc gaaggcagtt ttaaattcca ttatattaat gaagccggtg 141900
attcgaaata ttggaccttt aatcgtaatg gtaattttca agttgatact ggcggcttga 141960
cagttacagg cggtagtatt tccacttcag gaaacgtagc tgcttccggc tttttatcag 142020
caccacaggt taatagtaaa aatattattc ttgattcgaa aaatttcgga cagtatgacg 142080
tccaatcttt agttaactac gtatacccag gcacaggcga aacgaatggt gtaaactatc 142140
ttcgtaaagt tcgcgccaaa tccggcggca ctatgtggca tgagctttgt actgctcaat 142200
taggccaagc agatgaattg tcttggtgga caggtaatac tccatcatct aaacaatttg 142260
gcattcgtaa tgacggacga atggctggcc gtaatagcct tgcattaggt acattcacta 142320
cagatttccc gtctagtgat tatggtaacg tcggtgtaat gggcgataag tatcttgttc 142380
tcggtgacac tgtaactggt ctgaaatata ttaaacaata tgtttatgat ttagttggtg 142440
gaggttattc agttgcttct attactccag atagtttccg tagtactcgt aaaggtttat 142500
ttggtcgttc agaagaccaa ggcgctactt ggattatgcc aggtacgaat gccgcatttt 142560
tatcagccca aactcaggct gacgggaata cagctggcga tggtcagacg catattggtt 142620
ataactccgg tggaaaaatg tcgcactatt tccgcggtaa aggtcaaaca aatattaaca 142680
cccaagaagg catggagctt aacccaggta ttcttaaact ggtaaccggt gcaaataatg 142740
tgcagtttta tgctgatgga actatttctt ctattcaacc tattaaattg gataatgaga 142800
tatttttaac tacctctaat aatactgcag gccttaaatt tggcgcccct agcggagtta 142860
atgaaacaag agctatccag tggaacggtg gtactcgtga aggacagaat aaaaactatg 142920
tgattgttaa agcatggggt aactcattta atgccgccgg tgataaatct cgcgaaacgg 142980
ttttccaagt atcagatggt caaggatatt atttttatgc ccatcgtaaa gctccaaccg 143040
gcgacgaaac tattggacgt attgaagctc agtttgctgg agctcttaat gctaaaagta 143100
ttaatgccat cgaaaatttt aaagttaatg gattaagcac tttagtcggc ggagttacaa 143160
tgagcaatgg acttaattta actggcggtg ctaatatcag cgggccagtt aaaatcggcg 143220
gcgtcaccaa tgcattaaga atttgggact ctcgctatgg cgccattttc cgtcgctcag 143280
aaacatcatt acatattatc ccaactaatg aaaatgaagg ggaaaacggt gcaataagca 143340
accttcgtcc gtttagtatt gagttaggca ccggtacggt tataatgggg gataaatcta 143400
cgggcggacc gcttttcacg gtcgacaacg taagtaaatt cgtccagacg gactgtagat 143460
tccgtgttaa catggattct gatggtattg ttgttaacgc ctcatctcaa gcagcatcta 143520
actttattca aggtcgtaag gctgatgtga ctaaatggta tttgggtatt ggcgatggcg 143580
gcaacgtcgt tcgtatgcac aactacacat attctcacgg tattgcgtta aactctgata 143640
ctgtcgatat tactaagcct cttaaagttg gaaatgccca actaggaact gacggtaata 143700
ttacaggtgg tagtggtaat ttcggtaatt taaatactac catcgagaat atgaaagccg 143760
atattgttac cagttaccca gtcggtgccc ctattccatg gccaagtgat tcagttcctg 143820
atggatttgc tttgatggaa ggtcagacct ttgataccgc agcttatcct aagctcgcta 143880
tagcatatcc taccggtact attccggata tgcgtggaca aactatcaag ggtaaaccta 143940
gtggacgggc cgtgttaagc gcagaagcag atggtgttaa gtctcataac cactccgcat 144000
cggcatcaac tactgctttg acaggcacaa ccaatggtac ggacttgggt acaaaaactg 144060
tcagcactgt tgatataggg cgtaagtata ctaataacgc aggagcgcat actcacacgt 144120
tctcaggaac aactagtacg aacggcgacc ataaccaccc agcttcactt ggtaacaacg 144180
ccaacgttca atcaggtcgt tttgcagcat ctaactcagg tcagtctgct atagcatata 144240
ccaacaacgc tggtaaccac agtcacacgt tctcaggaac tacgtctgca ggcccagagc 144300
acagtcacta cgttgatata ggtactcata accataccgt agcaatgggt tcgcataccc 144360
atacgttctc tattgcggct catggtcata ccatcactgt aaataacact ggtaatacag 144420
aaaacacagt taaaaacatt gcttttaact atattgttcg tttagcttaa ggagagggac 144480
ctcggtccct tttaaatatg aaaatttatc acttttattt tgatactaaa gaattttaca 144540
aagaagaaga ttataaacct attaagggtt taggtctccc ggcccattcc acagctaaaa 144600
aacctttaga acctaaagaa ggatacgcgg tagtttttga cgaaagaatt caagattgga 144660
tttacgaaga agaccaccgc ggtaaagatg tttggactta taataaagaa catcttatta 144720
taaattctat tggaagttta tatggggtca catttgacga gcccggcgaa tttgatatat 144780
ggactgatga cggttggaaa gaagacgagg cttataaacg agtaaccatc cgaaataaga 144840
aaatagcctt gctacataaa gaattccagg tattaagtaa tatggttgaa gcttcagtcg 144900
cagataaaaa ggaaaaattc tatcatcaaa accttaaacg gttctttgct cttttagaaa 144960
agcatgagca tttaggtggt gaattccctg cgtggcctga aaaagaacgg aagccttggt 145020
ataagagatt tttcaaataa tacttctgta ttataaatat ctttaaagga gaaaagtatg 145080
gaaccaaaag taggaatatc attatcagac ctactttttg gacttcttga tagaattttt 145140
aaagatactt cttccgggaa agtagttttt tcccgggtcc tagtcgtgat attattgttc 145200
tttatggccc tggtttggta taaaggcgaa tatattctaa acttttacaa agagacaact 145260
tatgcctctt atactgaaat gattagacaa gaccaggaca atagatttaa aattgcggct 145320
atcgagcagc tccgaatagt gcattcttct tcaggtgcag acttcacagc aatatattct 145380
tttaggccga ccaacatgaa ttattttgtg gatatggtag cttatgaggg taaattaccg 145440
gaaacggtag acgcaaaaaa cacgggaggg tttccaattg acaaaacgtc agtagaatat 145500
atggcgggag ttaacgggaa ctattttgaa tcaagtaccg aaactgtatt ccttcctaca 145560
aagaagaaaa cacaattcac gtatatgttt tcatgcccgt tttttaattt ggataacgtc 145620
tacgccggct cgatatcgtt gtactggtat gatatcaaac cggatttagg atttcctaga 145680
ctttcgtcta tgtgtggtca agccggaagg acattaggtc gaactcgtta gaaattggag 145740
gtatacatca ttaagtaacg gtgtatatct tcatatcctt cattaaattg ctcaataaga 145800
gtgtcacgct catcttcagt taatgactta aacaatttgt tataagacaa accattaagt 145860
tcctttccat gttcattacg aatacctaac tcattcaaaa aggcaataaa ctcatcacga 145920
cgttgcatga tgtcttcaca atccgtttta atcaaaatgg aaacaatagt ggcaatttcg 145980
gaaacgattt caattttagt cataatattc tcttcaattc agtacgacat tatctgatag 146040
ggctatacta acatatcctt agggattgta aacatgttct tcgttctttt taacatattc 146100
ctgatacatc tcttctattg gttcctggaa cttaaaatca gctcccagga attcctcaaa 146160
ggacgcctgt tcacgtgtac gcatacctgt tacggtattc tctaagttat gactcatagc 146220
ctttaccctt atgtttctgc ttacgcttgg actctttaaa atttttcttc ttgtctttat 146280
gaacagaagc cttattgaaa tcgtgcttag ctaccagatt gttcacgtaa tttccttaat 146340
tgatattcaa gagagccgat aatttcttta ttagttgcaa tatacatatc acgtaggaat 146400
ggcttcaacc cttccatatt cccatggatt gtcttggaac taatattctt tatatattca 146460
tggtctaaag catcccaagc cggttggttg acataagttc cccaattatc ttccaccgtg 146520
acattcagtc gtttaacatg attaatatgg gcttcgattg catcaatctg gagttgttta 146580
agattcatta gtaaaggtcc tcagagtaaa gttctttttc actaccacca cgttcaatac 146640
gtacttgatt agcataagta gcaataatca ttgcttcttc gcgagtccaa taattgctgt 146700
attggtcgat aaatccttgg tcatcgccac aaacatggtc tgacacaagt ttatcactta 146760
cttggtcaag cacttctgcc atatctttgg aataatgacg agctcctgga ataactagag 146820
tcccaccgtc cttcagttta aaacggttgg ctgcgcatac aatcctgcgc tgatattttt 146880
cattgttgtt ccaatgtgca atctgccaac agatttcagg gacttcattc aaaacatctt 146940
gttctgtata ttcgtatcca tatgactgta atttggcagc cagactttca ggggtctcac 147000
gtgacagagc tttatctaac agagctaaac gttcttcaaa agttttcatt tgaaccatcc 147060
tttaacacgt tgccagaggc ttttctgttg agctttattg acaccgatcg agcgaataac 147120
aggttgtgat tcttggtatt ctttatagtc agctttataa acttcgtatg cggcatcaac 147180
aaaggaagaa atagcagcca tataattttt acgaatacca actgaggcat tatcattttc 147240
gcgaataatc agatattggc ctgctttaac cttaacgata gaaccgagat aagcgccatg 147300
gtaccagatg tcccaacctt cttgagtagg ttctgcacaa cgacgaagtt cattaacaat 147360
attcagcttg ttcataataa tttcctcagt cagttaaatt gcgttggtta cggctttgat 147420
aacttcagat gatacgtttt ggaagtcgat ataagtattc ttaccaccag tcttaatctt 147480
aacatcaaga ttcaaggaag taaacacttg tttttcttta tcagtcatat tataaccgaa 147540
gatgcgcatc attccatcac ggcgaacttc gatttggcga ataccattgg tacgtttggc 147600
gaatctaact tcaaggttgc tacggttttc agctatttca cggatttcaa tacggtcttc 147660
taataaagct ttaacttcat cagcaaatac caccatttca ggagtaacgc cacgtgaact 147720
acgtgtttta cgtttttcca gcatctctgg ggcattttca gaagcgaaca aatcagcagc 147780
tttttgaact aggtccattg cttcacctgt agccactaaa ccatcgccag atttttcgat 147840
gaatcctttc ttaatcaaca caccgatgtt agagttaact accgcagcac taaattgctc 147900
actcagggct tcacggactt cgcctgaagt gatgaagtta tgcttgatga tatgtactaa 147960
gatcgaagca gttttttcat tcaggacgtc ttcagaagct ttgatgatat aagtaatttt 148020
agacatttta atctccgata accatttatt tgataggtct atagtatcat gtttaaagca 148080
gaagtaaaca cttttttcac taaacccaaa aaaggaaccc gaaggttcct tactttttaa 148140
agtgggctgc tattaaacct atagctaagc ctgttgccag gcctagaata acagcaaaga 148200
tacagagtaa caagaactcg actccaaggc tcatagagcc tccaaatctt taacatactc 148260
agttaccaca tcagtggttt tccagtattg gtgctcttct ttcttagctt tagcttcgag 148320
ggccagtttc ttggcttcat cggaagtgat atggaaaatg ttcatggcca ctagtttatc 148380
agcatattcg ccgtagactt tattaccagc caattcttcg gttaaaacct tacgagtctt 148440
accttggata accactacgc cgtcaataac atctttgatg aatgtggctt tagccaatgc 148500
cagtttaaaa gcttcttcgg tttcgatgat tttaccatca atacgtttct gtacaaaggt 148560
cttacggacc tcaacgaaat cacgaatcag ttcaactgca tcttcgtaaa ccttaagttt 148620
acctttttca ttaatgacgg tcaggttttg tgaacgacgt tcgattaacc caaagtcctt 148680
catgattttt tcatgcttct tattttcttc ggagggcaat tcgtattctt tacgaatctt 148740
aaccttgaag ccaaaaccat tctcgtcaca gtcatcatca tatgtgatat accctttgtc 148800
ttccagaggg tctaatatct tggccacata tgtttcacgg tcatatttgt acgggatttc 148860
cgtgatatgc atttgggttc gagatgtgaa cttataggtt ccgcgaatct cataactacc 148920
tggttcaatc tcaaccactt caccacggaa ttctggataa gccactttag gcttggttac 148980
tcgtttttcc tgaagaactt gtagtacagc tttcttaaca gaatcaaaac tatgaggaag 149040
aatattagtt gcataaccag ttgcaatacc ggaaatacca ttaagaagaa cagtaggaat 149100
aataggcaga taaaaagccg gtggcttatg ttcgacatcc gcatgaaccg gagcatattc 149160
tgtgtcctta taaacttttg caaagttact tccaatacgt gcaaagatat aacgagaggc 149220
cgcagctttt tgaaccaatc gggaaccaaa gttaccttga ccgtccaaca aaggataatt 149280
gttattccat gtgttagcca ttagtgctaa agcttcttgg gccgaattct caccatgatg 149340
ataacccaag tcggcaacac caccggcaat agaagctagt ttatggaatt tgtctttatt 149400
tcctttaccc atttccaaag ctctacaaac accgaaacgt tggactggtt taaagccgtc 149460
aatcatatta ggaatggctc ggttttcaac cgtatacatt gcataggcca gggcttcgtt 149520
gtcaataatg ctttttaaat cacgagttgt taattccata gcaatcctct ttaaattgat 149580
ttatcaatct agtataacta atattatcat atcccatagg aataataact tttttaaagg 149640
ctttatcacc cggtttattt aatttaatcc ataaattgta aagcgtatta taattttccc 149700
aatgtttacc ttttctaaat gctttcttta atgctttaga atgtcgttct ttaactttag 149760
ggtccttaaa agccttttta acagaatcgg ataacttttt aactgattcc gggttttgcc 149820
acgtgtcttt tgctcttaaa gaagcttcta atctttcttc ttcgccccac cattctttta 149880
cagatttcga taatttatct cttttttctt gagagctcca aacagattta gaattcaacg 149940
atatttttag tctaacttca ggtgaattca tggcctctaa atggttcttt acatattccg 150000
ggttcttaaa aagagcttta gtagcatcag actttttctt tctggtttta tctgtattgg 150060
cttgtctttt tattcctttg gagtgcgatt ctttatttat tgggtctgcc caataaattc 150120
tcattttttc agatagaatt ttagaagcct tttctttagc tatagaatat cctatagaat 150180
tcaaccttat tcctttagga ctgcctgaag tataaaatga ccaatatgct aaataaagac 150240
cattagaatt gggataaatc tttgttagta tccaatgggc tatataatgc tctctagcgc 150300
ttaaaagaac tttattttca ggagtatcgg ggcctcctat gcattccggg attatatgat 150360
gaacttccga ataaaaatcc aatttgcctt ttttgagccc tcttccttta cccctatcaa 150420
ttattgcttt gtacaaatta tgataattca tttataattt taccatacta gtgaatgaat 150480
agccataata acatcggaaa taaaaagcac aacttggata agtccgaaca ttactccata 150540
atacagtgct actaataaag cagcaagggc tactgagtag cccaagattt gtttaatcat 150600
ttttaatcat cttaagtaaa ccgacagaag tagaaagaat ccagccaata aacagaaaac 150660
ttaagaatac cggaccaggg gtccacacac ctaaaaagaa gcaaaccgaa cagacaatag 150720
ccataataag ctcaataaaa actagaataa ccatattttc ctcattagcg tccgaagacg 150780
cctttagttt taagattgtt acgatagaac tgcatcacat gttcgttatg gaaattgctc 150840
attagtatgc ctgcagaatg aatttaaagt tatcagccaa catgcggttc atttcttcca 150900
gtgtctggag gtcggaacta tgattgcgag tgaaagccgt tgcaatttga cccttaccaa 150960
aacctgtagt cagaggtttc attttagaag ccggtacata aagaacttca tacacaacac 151020
cattcactgc catagtgcgg gctgattgag aacgtttctt acgaatgtta gccacgatac 151080
cgtcgagacc ttgagccgaa cgttgattac cgacataaaa acgagccgct acgacacgag 151140
aatcagctcc gcctttaaca aagaagtaga agcctggctg agcagagatt tctttagaag 151200
gtttaccatt ttgatattca ccgttcttaa cataagcaac ggtagtagca ccagcagaca 151260
gaacgttacg gcgagtcata taagtattca tatcaatttc ctcagtagat taatgttttg 151320
ttatccagtc aacgagaacc attataacat gattctcgag gttgtaaact atttttgtag 151380
ctgttctaaa ataaatccgc tggtataaaa ggtagcatta taaaccttgt tcagcgggct 151440
caaagcctgt ccgtaagtat cacgtagttc tttgataaca ttttcataac tcacataata 151500
gccgctatga taatacgggt ccatactcat acggaattta atgaaccgat aaaagcctgt 151560
ttccgggtct tgaacgaaaa cgaaatcagc actcgtcata atttttgaat ctacgccggg 151620
aatcatactt tgattgaatg ccaccgatgc atcctgaagg ctgagttgtt taaagaacat 151680
taccttagca ttaccaaaaa agattttaga catgataatt tccttattca acgtcaacag 151740
aaatagccat cagttcatca acagtaagac actgtacact ggggcctaca caaaaacgct 151800
tagtcgaatc ataaaggtct gtagcattaa caggttgtaa ttcggtccca acttgcaaag 151860
gagaaatgcg aatcagttgt tggccgttat gcaatacaaa gctctcacca actgcaacat 151920
ctttaaaaag tttcataata ttttccttag aagttaaaga atacacgtac atggtcaatc 151980
ataaaaacga ttgggaaaat gctcaacacc attaacaaca caaacatgtt ccaaattgct 152040
ttaagtaagt ttttcataat catctccatt agttgatagg tctataatat catgattaat 152100
ggagatgtat actgatttat gccaatttcc acaacaataa actaaaacat acgcaaatca 152160
ctgggataca ggccatccaa ataaggcacc acattttgct actcaaaaca ccacctcttt 152220
tatctcaatc aatcccctgt acaatgcagt gcggaggtca taaagaatat ctatgccgtc 152280
gacattatct agtttaccgt cgataagttt ttgtaaatct tcctttgatg cgattaaggg 152340
acggagaaat ttacattcag aaagagataa ctctgtagta acatcatcac cttcacctga 152400
cgcgtcatac atagcggcaa caaccatacc tgtaactttg tgtttagcgt aatataattt 152460
gatatccatt ttgttctcct ctcaagttga taggaagata gtaacaccat ccgtggtgta 152520
tgtaaacact tattttaaaa aattataagg cgagatacca gccgttgtaa ttgctcttac 152580
ggactagctt tttgatggct tctctgtcac cagagaactt aggagtgaac aggacgtcgc 152640
ctgcctcatt tactgaagtg tcgaatataa ttatacagtc tgcaacttta tgattcaaga 152700
gcggccccag gttaatccct gttccatacg ggaagtcacc cgagtatcct gtagtacagg 152760
aaatccactt agaatctgat tgatgggtct tgacctctac acgtagtcca caatacatag 152820
gatgggctaa aacgtcccat gcataggtat aagggtcatc atggtcttcc aaaccactat 152880
taacataccc tttcaaccaa tcagcaacca tgtactcggc gtacgttgca atgacacacc 152940
gagtcaatac ttctttctta tcttgggacg ggtcttgact taaggaatac aatacggtat 153000
ccttaatctt aaccttcatt tcgcctgtta aatcagatgt cttcagggta aatgtcggca 153060
tcgctgccaa tcggagtagc cccgggttcg tcttcaccat aaatgcctcg aatatgaagt 153120
tcgccgtaat aaattcggtc gtcgggttct aaagtatcag aatcaattaa aggaaattca 153180
ccttcgacca cctcatcgca ttctaaaaaa gcgtaatgaa catcaccagg gtgtttaaca 153240
agcttagcac aataaacagt acctgcttta tggaacccac gcaaattaga aatcttgata 153300
tcacgttcac cgacattcag ataattaatc attttactca ccgaaataag aaatacgaac 153360
ctctaaacaa tgagcatatg cacccatcgc atccagttgg gcaatcagta acccttgttg 153420
acggatatca agagtttcaa aaacaccgcc tttaataaag gtttctagtg cattaatttt 153480
aagaactaac tggtcgtatt cttcaattaa acgtgcttgg taacctaaca taatttcctc 153540
ttaggaggcc gaagcctccg tttagtttta acgtaaatct gatttaaact gttcggtaac 153600
gtcttccaga acttcataat aacatacgcg cattttagca tcgccataat caacaggaat 153660
actaacaaca tcacgtgggt taactttaca tgaaactaca cggttgtttg aattaccaaa 153720
tgcaccgata tagctacgag agcaaacgtg tagaccgctt gaacaagtta ctgtgtcgtc 153780
attgtttaca cgtgaacgag gcattttaac cggtttgcct ggtgagttat caaacgtacc 153840
agtacggcag tcggtgtaat cggagttaac caccttccac gtaataaagt ggccatcttc 153900
agtaattttg atatcgtttg caaccaggaa gtcgaacaaa cgttgtacag ctttttcgct 153960
tgggttttct aacaggttct caaggaacgg caggtagaat tcgaagtctt cgccattttc 154020
cattgaagca ataatacggc caatcaaccc tgaacgcaat tcaacgcctt ggtaaaccag 154080
acgtccacct tcaatacgaa cgttaccttt gacgaagacc ttaacagctt ctttaatgga 154140
aatcagttta atcgcgtcgt caaaacggga ttctttaaga gcctgtacga tggcatcaaa 154200
atgtttattc ttattagtgg tgttccatac tgtacggcct tcggtgatgg acacgaattt 154260
agaactggca ttccaaataa tttcagggcg agaaccaccg atagtaatat caaccggaac 154320
tacacgaggc tcgttaggaa ccgttacttt gatatttccg gtaataacca cttctgttgg 154380
ggcattaaga ggtacagtag gcgctttttt aagcgattcg gctaattctt tagccacttg 154440
agaacgttta gcttcttcag catttttcag gactttacga atggtatcaa ccgaaacact 154500
gtaccaatcg gctagttctt gctgagtata attaccggat ttatagaggg aaactacttt 154560
ctcttgttca gatttagcca gacacttaat attgtacata atatttcctt agattaagcc 154620
gcttccacgg ctttcatgaa tttaacgatt tgagctacag aagcctcggt aatggatgtt 154680
ccacgacgat acatgtagtc cgaaactaaa tggtaatcag attcaaactg taaagtcatt 154740
ttatcattgt tgcttgaagc attattggtt aacgtattaa acgtggtgtt acaaattttc 154800
ttgataacag aaagcttgtc atcagtgata taaccatgga aattcatata acggaatata 154860
tcatagaaat tactcagacg agtatatgct tcagtcaccg gcttatcact aaaatacttg 154920
gtcatgaaac cgagctcagg gaacttggca atgatttcaa ggtaataccg agcacgggta 154980
ttactaccaa ggtagtcatc aacatctacc gcgtctaggg cttcagcata ggcttctaat 155040
gtagcttcca tcaggcattc acactggcct aactttttaa tctttttggc aatctgaggg 155100
cgaatgatat ggaattctgt tacaccaatc aaattagcca tacgacacat ggtagtggta 155160
ttgatgtcaa agataccata agcttcgtcc attcccatga tatcagaacg actgccaaac 155220
agaacataac ctgtaatttc ttctgcttct gcggcggtca aatacatggt ctctgtttgc 155280
caacgtccat ctttaatgaa ccaacgataa gcactcggtg ttttaggacg aggttctgat 155340
gagcgaacag taactggaat ccatggctta acaattttat tcagttcaga gactttataa 155400
aaatgaattg tgtcaccttt aaaaagttct ttaacctttt caagctgctg catttgcagc 155460
aaagaattag ggtcgacaaa aataaggtct gttccgtatt taggaatatt gtgctcttta 155520
acaattttct tggctgaagc actgttgtcc attgccagag cccaaagtcc tcgaactaat 155580
ggaacacggc ccttttcatc atcataaaca acatggattt ctttcttatt aatgcctaat 155640
aaattactaa gtcctgctac tgaagaagta ttaccgcttg acttaattcg tttcaaacgt 155700
gggtctgaaa cgacttcgta aaccacacct aaattaataa ggtcgttttg aagggtataa 155760
cgctggtata atttctcata tgtcaatttt tctgtagtaa acaggctagt tccacctttt 155820
ttagtaagat agtcacgagc gctgtagcca aggttagaaa ggtcacgata aacatggcgt 155880
ggattatcag attcaaccca ttcctgtgta tcgtttttaa agactaccgc atccagtgct 155940
tcgatacggg ttgcaatatt ttccatcgta cgtttatcaa gagacaacac ttcacgagac 156000
ggagcaatat ccagtgaacc catagggaac ttaatataaa ccacatcatg gcgagtacgc 156060
atccatgtgc ctttaatata ggcggaatcc aatggataaa caataccacc gtaaacagca 156120
taaagtcctg aacgttcgaa gctgccataa tttgtagtgg ttacaggatg gtaatcgtca 156180
aattcaggga aataatcaac ttcaacacca tcgacatcac caagaccaac aaatggacgc 156240
atgatataac gaatttcggt ttcaaactta cggaaatctg attcatctac aggaactgtg 156300
atttcaatgc ctgttttatc acctggctgc ataggttcga cgaaagtggg tttaatctgt 156360
gggccatcac cgtccatata agctacataa ccacgaactt caccattatg ccatgacgtg 156420
atattaaacg tttccgtata actaaatgga gattttgaac caagtccaaa gccgccgatg 156480
aaatcattag aagaggtttt agaagaagca aaataagaat tatacagacc tggttcttca 156540
tcattaccac gaatctggaa atcactcatg cctggaccaa aatcacggca tacgaaacgt 156600
gggtccagtt taccaggaac ctgtactttc cagcgttctg tattaccatt cagcatatgg 156660
gcatcaatca tgttagtaat cagttcacgt actacagcac gtactttatt actataaagg 156720
tctgatgaca gaattttaaa gaccttaggc gaggcctgga tagtaaagcc tgtggactta 156780
gcgccattac caatgatttg ttctttttcg gtttcaataa tcatattttt ctcaattcag 156840
gttacgttta aaaatgtctg ccacttcaag gagctcgtcc ttagtagcga tgtcgttgag 156900
tattttatat ctgatttctt taaagcgttc tttaaaatcc tcagctgcat tgatatcaaa 156960
aaatcgctgg attagccgga attctttatg gacggcttta tcgaacaaat caatattcac 157020
tttaaagttt gtcattttta actacctcat gttgaacata ttctctggta gaacctagtt 157080
cagccagaat tcttctcata gaacccattg tacttttgtg ctctctgtgg cgatacatta 157140
tctctaaaac cttttcctgg acaacaggag agagcgcctg gttatcttta atctttaagg 157200
caatagattt tacagccttt aagtattcga gtcccttacc gcttgtagtc actactcctt 157260
catctttaca gttacgaata gccgtttcca taaaggataa agccaggttg tcagtattca 157320
ctatactgtt atcttgcata atcatattct cacctctaga taatcctatc acagttttgt 157380
tatgttgtaa accccgaaaa gggcccgaag gcccttaatt attcaatttt gtagacttgt 157440
cctcgaactt gataaaattc gccttcccag gtttctacca taatggtcac gtactctgcg 157500
aacaaaggtc tcttctcagc ccagagatat ccaaattcac cggtggctag cgttatccag 157560
tactttctca taaagtctcc taattgtatg gcactcatgt accatacata tttattacga 157620
catccaggcc ttacggagtt gagggtcgtt tcctaggagc atttcgaact gttctttcca 157680
atcttcaggc aattgaacta catcaaattt agggtcttga atcattcgac ggtattcaac 157740
tttctcaaga gaaccgagac ctttgatata acgaatggag tgttttggta gagagtcctt 157800
agctttggta taactaggga catcgtagaa ccattcctgt tctttaccaa cctgagcaat 157860
aatcactgga gttttacaga accgcactcg gccttgttcg aacaattcag gccattgact 157920
aaagaaggct agcaatgatg gataaatcga acccgtacca tccacatcgg catcggtcat 157980
gatggcaata ttacgatagt tagttttctc tgcaggttca ccaataacca gtccagtgat 158040
tgcacagata tcaaatagtt ccttgttctt catgatatct gttgctgtca ttccccaggt 158100
attcataacc ttaccacgta atggataacc accttgaagg tctttattac gaacttcaat 158160
gaaaggaccc atagcggaat caccttcggt taggaacagg gttgtatctg catctttgcc 158220
gtataagtta gctttaatat gcttatggac cttggcttta gaagctttct tagcggcttt 158280
agtttcagct gccttttcag ctgctaattt acgtgctaaa gccgcttcaa cgataggcat 158340
aatcaaccct tcgtctttaa gaatatactg tgagattttc tttgcatcaa tttgaatatg 158400
gttacgaatt tcaccgaatg gtgacgtcaa acgttcttta gtctgggaat caaaacgcat 158460
attactcata tcgcgaatga acatcagcat agttaagcat tctttaactc gtgccttact 158520
tacttcgatg cctttatatt tcttcttgat gcctggcaag agatgttcgc agatatcatc 158580
aaacacacat tcaacatgat gaccaccatt cttagtatga atattgttca cataagttag 158640
gtgacggaat ccatccggag atgtagtaaa tgccattgag acattatcgg tttcttgaat 158700
tactacatct ttaccaaatt gattagcata ctttttaaag ttaccatcta cttttttacc 158760
attaaaagta aattggatac taggataaat tacagctaga gttttaagac gatctagagt 158820
aatatccaga taaatttgtg atagagagtt ctcttcaaaa tgattaaagt ctggagtgaa 158880
tataaccgaa gtacccttac ctttagattt cttagtagac caacctttgt tttccattcc 158940
attggaacag ttaactgtaa tttcattctc gccatcagag gtgatgcctg tgaacaaaac 159000
agagaagata ttagttaaac tactaccgac accattcatg ccgcctgtct tacgctcagc 159060
gtcatctcca aagttaccgc cagcctttgg aatagtccat gcagctacag gacctggaat 159120
ctgttcacca ttttggtcgg tgaccattgc ttgtggaata ccacgaccat tatcagaaac 159180
cgaaacctgg ttattcttaa tttgaacatc aattttattt gcgaatttaa aattggtacg 159240
aatagcttca tcgacagagt tatcaatgat ttcgtcaatt aatttaacca gtccaggaac 159300
atagtttacc tgtgtaaaat taccaaacag gaatcgaccg tgggcttcat tagcactgga 159360
gccaatatac atcccactac gttttttgat atgttcaatg tcggacagta ctttaatttc 159420
attcttaatc atgttatttc ctcatgtagt aggagaatat tatcccattt cacttaaagc 159480
ataaaagggc cgaagccctt aatcaaatcg aatggtcgac tttttaaaga ataatccaga 159540
acaaacagtt ccttcaaccc ttttacccgt cggacccaca gcaataaagc ctgtacgttg 159600
gaaatcatct tcagaacagc caaataggtt atatcctgtg atttggattt gttcgtagcc 159660
atttgcatcc aatacacggg tagcattatc agcatcagta caaccgacca acgaaaccgc 159720
cagtaccagc gcggcaatag aactattaat gtatttcata atttctcact tagtcagcag 159780
gtcgtaaaaa ccgccattaa catgtttagg agccgagact aaccgaacag ccagccgatg 159840
gcagtcaggg caaacatcat tatctctttc agagattttc ttgatttttt cgtattcttt 159900
tgcacagtct tcagattggc atttgtaatc ataaagtggc attataagtc tccttccaga 159960
attcagtgcc ttcagcagtg atttcacgga acactgcata gataggggtt ttatcacctt 160020
gattttcgta tacataaacc gatgataaat gagaaaacgt atcagaatgt tccttttgaa 160080
ccacgattaa atctgggttg aacagaacat cttcaaattc ttcacgagtc gagttcatag 160140
taactttagc cattttattt tcctctcatt tgttgatagg gtaatcttat cactacccta 160200
ccatattgta tactgttttt ttaaacttta tgcaaaatga atatcagcat actcaacgat 160260
aaagctctca ggaacaacct taaaggttcc aaggaacacg atgttataga gcttaacgcc 160320
ttcttcaacc cactggtcgg tgatgtaacc ggacatacta gtggtttcat aagtcggacc 160380
gtacttgcac ttgtattcaa acggtttagg tgaaacgaaa aagacacctt tacctaattt 160440
ccatttgaaa tcaacaccaa catgagattg gtcaatagtt tcaacgtctt gagctactac 160500
gccacggata tcattgcttt cacatacata cccatcatgg gattcaactt cttcaactac 160560
aggagcgatg tatccagtga attcagtcga ttccaagaat ttagcacgca cataagcgaa 160620
ttgagtttca gtctggccat ttttaggaat gatacgcact tttacttcag aattttctac 160680
actgacacct tctttaagtt ggatactaac aacttcaact aaacggcctg cagcttttga 160740
acgagacttt ttggatacac gaacgatacc gccgatatcg gaaatagtaa tcataatttt 160800
tctctcttgg ttaaaggttt attctccatg agagccatta taacatggct ctcgataaag 160860
taaactatta attcaataca ttaaccactg cactacgagg tactacacta aaatcaccag 160920
catgtacaac gttcaggagc tcaacaccgt cttcaatcca ttggtctgtt acccaaccac 160980
agataggatt atcaaaagga cgacggatag acacagcagc acacaacagg tcggtagggc 161040
cttgttcttc aacttcttgg aacaggatga actcatcttc ataaaccagg gttttctcta 161100
ttttgttatt atctaaccgg cgaccgtgga tgacgtaaga tttagtaaac cagtcacttt 161160
tggcaaattc ttcaacaata aattcgcctt cgccaaaaac atcagtcaga gttttataac 161220
cagaaatcaa ggccttagtt ttaatttcag gttcaaccag tttgtaggtt ttgccgattt 161280
cgatagtctg agtagtcata ggtgattcct taatttccag tggtttaaca gggcatacat 161340
aagtgcttaa aacatcaaaa tcaatcagtt tagctgccgg attcggggta tatttagggt 161400
tataattaaa tttcatattg ttctcaattc aataaaatct acgagttcgg catgggattt 161460
gcggaacatt acttggcggc caccaatgac aacctcatct tctggtattt cgtaaacagc 161520
aaggtagaat cctttagaag ataattcttc acgctcttca cgagtgaacc agcgcatcat 161580
atcatactca ctggcaaaag caaaatggta gaggttaaca aaccaacctg gaatataatc 161640
gtcagagcct tcataatcag gccgtttcca cttagttcta atggctttat tagaattttc 161700
taccaacaac ttatcttgac ttggtagtgg aatattttta ttgacggtat gatggtgcct 161760
aaacttaggt ctgtcgaaac ctacttccaa taaccatcct tcactccatg agtccattgt 161820
acttctatat ggagtcattt gggtacagag gtctcgtcgt attgttatag catcttcaca 161880
atctaggata ctgaacgatg actccactcg ataaattttc attttgttct cctcatgttg 161940
atagggtaga taatatcatg tcatgaggag aagtaaacac ttttatcgat tttttatact 162000
taatgggtcg ggattctcag ggacatcttc caggcccaag gcgtatcgtt gggcatattt 162060
aagcatcaag atatccttag cacagtcatg gatggagtca tgagcaacaa agccgttcaa 162120
tgttccgtta ggcagaggac acatgctcaa tccacgagtc aatgaatatg cttcaatagc 162180
cgtacggatg tcacgttggt tccagaattt aaccggttct aatttgctgg tatcgatttc 162240
attctcaggg acaccttcag aacgataagc atcgcgaata aggtcgacta agataggaaa 162300
gtcaaaggac attccacggc accacatctg agatttccat tggtctactt cgtttttacg 162360
gcagtattcc aggaaattac caaggccgat agaagtggtc acatcaattt cggacggcgc 162420
caggttttta cgtgcttcag gcccttgctc tttccaccac tgcaacgtgc ttttagaaaa 162480
cagtcgttta tcacgttgag aagcgaggtc aaatttaata cgaaggcctc gttgagtaag 162540
ctcttcaaac gtttctacaa cctctggatt ggggtcataa gcaattacag cgaggtcgat 162600
aaccgcggca ttttgggttg tggcaaaggt ttcaaagtca ataattatat ctttcattta 162660
acgtacctca taaggtctcg gatttggccg acggtgtagt cttcaatata aaccgaagag 162720
atattgtcgt ccattagacg ctgtattgca ataaaatcgt attcaatctc tttaagagaa 162780
tgcaagacct tatgggcctt gccacggata ttggtatcgt cttggttgac cttaataata 162840
tattcagttt caaatttcaa cttataaaat tggtctttgg ttactttaat catattttcc 162900
tcaaacgtaa taagcgtcag tacgagcacg agtaatacta acataagcca gctgtgaagc 162960
taaactcaca tcagccatat gcatacacgg cgtatagatg aaactgttct ggactgtgag 163020
gccctgggat ttatgaacgg tgctcaccgg aagagctcga accttagtaa acattctctt 163080
agctttccaa aaatcggccc acttaggttt cttaccacta ccacgcatgg ctttgtattc 163140
agtagcaacc ttagccaaga aataatggaa cttctcgact gaagcctcat ctataacctt 163200
taagtgctct acgtaatact catcatcttc atcgatagat tctacttgca ggtcccagta 163260
attaatcatt tgacgggtgc ctacatcctt agcagacaag aacaatgagg tgtggttcac 163320
atccagaata cgaaccattt gaccgttatt aaaaatggtt tcagagaatt tcttaccgtc 163380
gtattcaagt tccttcataa aaggctcttg catcaccagg atttcaccct tgatataagg 163440
tgcgtcggtt tcataaagct ttttacgaat aatgctattc agcttttcaa ccgatttatt 163500
tgtataagca aacatcctat tctcaaacag tgcatcagca tcctttacaa tggaaaaata 163560
attcatcata aaatctttta atgctgtttg agatttaaaa ccatggacac catgtccttc 163620
gaatacacaa tctctaaacc acccaccatt acggatttca gtagcaacct caatgatagg 163680
ggcattacta cgcattactt cggtcaaatg caattgcttg atttttggat gagtaaagaa 163740
cggagacaac tgcggactac catcacttcc aggttccact ggctgtagct gagctcggtc 163800
gccaatccct aatacagtac accatggagg cacggaagat tcgataatct taaacagctt 163860
accatcaatc atcgagcctt catcaacaac taacacatta catttgctca agtcaggagc 163920
ttcgcgttgt tcaaagatat cctggtcttc gtatgtagta gggttaatct ttagaattct 163980
gtggattgtt gatgcttctt gacctgcgag tttcgacaac acctttttgg ccgcatgggt 164040
aggtgcagtc aaaataactc cgagttcacc attcttgact agatggtcaa gaataaattt 164100
ggtaagggtt gttttacctg taccagcagg gccattcaat gtaatccatt cgcccttacg 164160
tcgtttaata gcttcaatga tttctttaaa agccgtcctc tggccgatgt tcaagtcttc 164220
aaatgtaatc atgccaattt tactcgctta acatataaag tgtctaaaac taatttaagt 164280
tctcgggctc gttcttcggt aggatacacg gttttagttt cccacttatc aaaccaccat 164340
tttctaggtg tgcacaccgt ttcaaggcgt ccaagccgaa gatatctttt tgtcgccatt 164400
tcataaacgg atagagcggt atcggctcca atctttgtcg aatacaaagt cacttcacca 164460
gcctcttcta atggaatttc gtacccgtct ttgtccttgt gaactaatac gtatgcatag 164520
tacatcacgt taacctctaa tcagtgaaaa aattgaagca ttcagcggaa gacctttttt 164580
caacttcatt ttgtcaataa aagaaaggtg ttctaaacgc tccagacctt ggataatttt 164640
atcatacata tcgtaacgcg tttctgcttc agacaattta aacttgacgc gccaatcagg 164700
cccaccaatt aaagatttaa gacccttttc catagtaccg attgaagcgt tagaaccatg 164760
gatacgagcc ttaaccgcga tgacagaagg ggtcttatca gtagctcctg atttaataag 164820
gtccttaaga cgtttttcac gctttttaag gcctctttga gtatctttaa tatttttaac 164880
tattttacga attttataat aattatcggg ggttacttta aaactattag gcattttaga 164940
actacctgaa atacggaccg ctaaacgggt ttgtgcacgt ttcaattcat ctagagacaa 165000
atcggcacgt aagctattgt acttgacttt aactgggatt acattaccct caatatagcc 165060
gatatcatta ttaaaacgtt caaatgaaat cttatcacta actgaattct catcaaagct 165120
ctcgcctgaa taagcacaca ctttttgttc gagaagtcta cgaatgtact tactagacag 165180
gttaaagtcc ttaccacgtt tcttggcaga ggctttagtg tgttcgcgac gtttgtaaac 165240
ctttaactca aattcagtag tcatgatatt tctcatctta cggacgattg gttgataggt 165300
ctatagtatc atgttgcccg ataaagtaaa caactttttt gctttaaatt ttcgacggta 165360
taatgaatca aggactttgt ctttcaatta aaccgggagg ttcagtaaga aagaacggaa 165420
agattccaaa tggtgtaatt attccattta ggatttctct caatagagtc tacgcgcagc 165480
gtagttcccg cagggaacat catctcatct tcatcattga ttaattgtaa gtttgctaca 165540
cgggtagatt caggaaatgc gcctgggaac tcttcagggg gcgcagcaca taacatttta 165600
aagatttctt cctgataatt gtacacaaat ggtgcatcat taatacaaaa gatattaaat 165660
gtgccgtaga agttataaga cgcgaaattc cttgccacgt tgaagtcttt agagaagctc 165720
atcacgcggt cgaattcaat taccgcacct acacacattg tggactctag atacttcata 165780
gtctttttag atatgccacg atagagctta tcaggcacta cagaagtcag attcttacgg 165840
ataattttat tcagagtttc ctggatagta tctggtttat tttccataca ctgccagagc 165900
gtgctctgtt ctaaatcaga atacacctca tcaatttcta tctgagtatt ctcacggaaa 165960
tcatcgcatt tagcgttgtt gataaattct gctaatttat ggcttgggta taacatatta 166020
ttctcctcag ttgatataaa gatagtacca caagcctcct tgcctgtaaa ctaaaaatcc 166080
aacattttta aatgaattgt tttatactcg atttcgtacg ggtctctttt gacggtttcg 166140
attgcaacaa tctcaaatcg cgattggctg gagaccatga actcacattc ggtttcgacc 166200
atatcataga ggtcaatacg ggtttcatca atttcaaggt cgtctacatt acctgcaaga 166260
acaaggtcaa tagcatggtt gtagtagtca aaaatgaatg gtgcattcct gagacttaaa 166320
atggttttgg ttccatattc ccatgcccct gcaaactgac gagcctgaga gtattgtgta 166380
ctaaaagaag taacgcgacc aggagaccat tgacaaccta ctgaaaggag ctctaattgc 166440
tcaagttctc tgggggtaat cccacgatac aactctactg gaaccgctga agtaacatgc 166500
ttgcgaacca gtttgtcgag gtcgtaatgg aagttagggt cctttttagc atccagacat 166560
ttctctaaca aggcttgttc agattttgaa aatttggaat tgattcggtc ttgataaaga 166620
catttttgtt cgatgttcat atgacctcca gtgatttaga ggtcattata acatgaaggg 166680
aggaggtgta aactacttaa acacaccaag tgggacgcca aacactgcaa tgtcagcagc 166740
catgcctaat gaggattggg tatatgaagt ataggagctt tttgattcat acgagctttt 166800
tgtttctggc ttctcggctt caatcttaag agctttcgcc tgaatatttt tttgctcggt 166860
ttccttacga gcctgtttac ggtcgatatc caacgccgat gtaggtatat tagtcagcca 166920
attcattatt ttacccaagg agcccatggt ggagggtcta agtaataaga agcaaggtca 166980
ctaaggacct ctttaggcaa cttaaaaccg tgcttctgta taatcatatc aagttcgttg 167040
acaaggtcaa caggcggctc ctgggttgtt tcaggctcag ggtccggaat gacaaacata 167100
tcaaataagt ccattagtag ccacctatag gaccgtactc gtacatacga gctcgcacct 167160
tagcatcacg aatagcgtct tcagtcatgg taaagcgcaa tccaatatca aagtgcttcc 167220
aaatctgacg ttcaacttca ataaggtctt cggtagcgga aataagataa gtacgacctt 167280
taagacgttc gttggacatt ctatcggtat ctttatagaa aatgtccatt gttccttcgc 167340
catacgggtc cggatggcga taacccttga tatgcaatgc ttcagccagg ctaaaaggac 167400
aatcttcagc aacatcaaca tttttgttat ggtaagcctt catcataata ttttctggca 167460
gcttaatatc ttttaatcgt gtttctaact gggttataga attcgtacca ttatcgacaa 167520
ggataagaca cgctgtagca tcataaggtc gcgtttgtcc ggcagaatca cgaacaaaga 167580
attctagttc ataaactttc attatgtttt cctcttctta gtttacctac taaaggacca 167640
tccggaattt tattttcttg gatgtatttc tcgttttctt ccatcatttt actaccaatt 167700
ttaagaagca aatccagtgc ctctttagcg tgtttttcag cctcttcagt agtcatgatt 167760
tatccccata gatgtcacgc ataatcctaa gggcctcgcg ttctaatttc ttttcgcgtt 167820
cttcacggat acctttaaga atccattctt cggagtcacg tttcatttct gcattggctt 167880
ggtctaacca cccgtcatca agataatcac taggacggtc cagccaatct ttaagccatg 167940
ataaaggttt cattaatcac acgagctaga cgacgagtca cagcttcctg agtcataaga 168000
cgaataagaa gaatcaccag tccaagaact gacagcagcc gcaaccataa taggagtggt 168060
atcaatatgg cttgtgcgac gagcttctaa atgttctttt aactttttag atttcaaagg 168120
aagagcgccc gggcctacat taccagcttt ttcaggttga cgaataactt cttccatcat 168180
accatcgcct acataaacat attcccttaa cttaacgtct gatggactaa taggaaccgg 168240
cccttcgcca ggggtaatct tgaaaaaatt cttaagccaa caaatcataa gaaacctcgt 168300
ttaaattcaa ccttatcaat atcatcagtc tcgtgacgga tttcggcatt aaattcgata 168360
gaaccgtctt catgcatcat aaatgaatgg acaataactt cggtatacca aggagtataa 168420
aagtactttt tcaatacatg attagcgata atttcatcca aagttttatt tggtttaatc 168480
caacgattta acatagtgtt ctcctctata agataagacc atcttaacac aaccttccta 168540
aaaagtaaac ccttaagacc aaaaaaagga acccgaaggt tccttataat taaactactg 168600
gggtcggcgt gaacattgct gcgttcttag ttcgccaatc ggctgcatca gtcactacag 168660
tagtataggc tgcaacggcc gaagggaaag tctgataatg agagtctgca atacggtgct 168720
cgtttgaata aatctcaaac gggaccgaaa cctcagtacc tttaacttct ttaccttcac 168780
cagctggatg cgtaaaagtt ttgatattaa cgaaaccacc cataattaac tcctttgttg 168840
tttaattaca ggtgtattta ttacgcatat ttcttatcaa tataaaagtg tccaccgcct 168900
ttaacaaaga cccagaatag atttctatcg tctgtatccc gacaataaaa atcatctaac 168960
tggaaatagt tttcttcagg gaattcaaga tgccggccga gttctattgc atcagaacca 169020
aacgctttag tagcgggacg accatcatcg tcccatttct tgaaattgaa tttcattaat 169080
aaccacggtc ctgacgagca aagttctcag cgtttttcag gtaatacaat ttaaagattt 169140
cttcagcagt cagaccgaga ccttggaaca tgttcagaac gaaatggaga atatcaatca 169200
tttcgaattt aatttcgagc tggtcttcag gagacaaatc gttaatcagg gtttcacgac 169260
gttcagcatg ttgagctttc caaggcttcc atactgcaga tgcatctttt tcgccattgc 169320
tcatgccacc aagagaagtc agaagttcac ggaattcatc atcaatataa tctttctgat 169380
tacgcaacca atcaacaact tcacctgcag tggccaaatc atcaggatga cggttatatt 169440
caggtttatc tttagccaaa cgggcctgta atgatttctg catatcaagc ataacctgca 169500
gagggtcttt atcttcgtga atcagagcat taaaataagc ttcctcagct ttatcaacac 169560
cagcaatcaa accactacat tcattaaaat gagccattat attttccttt ttcaattcat 169620
taataagtta gataattata acattaaaat ttataagcaa ttaggaagac cacccggtga 169680
atttgcgttg tcctgaatcc cagtgaacac ccacgtcagg agaataccta taattaaaat 169740
caccatagga ttctgaaatt tctaaaatat atcttacaaa atattcacaa agctcattag 169800
accatgaatc agaatacacc acgaagtgga aagatgattg gtcctcatca tcgacatcaa 169860
tccacacacg ttttaattta ccttccggcg aatcataaac acctgaaata tattcacctt 169920
taaccgaaag gctcccttct tcaaaagcgg tattcaaaac aagccctaat tctccagggc 169980
tagattcttc tacccaatca tcatgggtat tcaataaaat cttaatcata atatttcctt 170040
aaaaatcaaa tatgtctaat aacgaattgg tggtattaat atgaaccacc ggagctacat 170100
aatcatccat ccattctgga tatttacgcc cttcagatcg gtcattaggg tctaatgtat 170160
ttgcatatgc aaagttatat gaaattatat ctcgatgttc tttagtatca ccaacaatat 170220
ttaagatacg ttggcataaa aaatcatagt tatctttcat atactcaata caatatatat 170280
cttttaaagc ttgggttggt gatactccaa tttccaattt cttacggata atggcttcaa 170340
caagattacc atctcctgct gaaggttcaa agaatgtatt acccgcctta aaagattctt 170400
caccgcaaag ctttaaaaga atttttgtac agtaatcatt agtgaatacc tcatcagtag 170460
atttctggcg ttctcttgtt atttcaccgt tttttcttga ttcatcaatt gctaatttca 170520
tcaaggctca ccccattcac aacattttct gcatactgcc attctaaatc ggtaatgttg 170580
aagcgttctt gaatcatttc acgagtccat ttcttagtaa aatcgaccac aggagcattt 170640
tcaaccattt ttttgcctgc agtaccacca ccaagtccgg cataataagt gcatgctact 170700
ttaataggag gcatattata gaatgctata gcattttcag cttcttcaac agtatcaaac 170760
gaggcccaac attttttgta attacctgaa ttatccccac cgtgtggatg tgaattctcg 170820
attttggttg ctccgttcac aagaccgtta tagaaatcat tacccattat aattttagaa 170880
cctgctaaat gtactgataa tttacggttg aagtttacat aaaccggttt ttcaataccg 170940
ttataaccat ttaatttctc ttcagtgcga gttttatctg caatagattt tgcactaata 171000
ttgttaagaa ttaatgaaac aaactcatta ttcatatact cgtatttggc tttagagcac 171060
ccgttaacca aggtataact aggggattca tctttagtaa atttagccaa agccagatga 171120
gttcctacgt tagccgagaa atatttgtta tcacggttat cgtcaataat tgctattttc 171180
aaacgttttt tagcttcagg ccggtgagca ttgacaccca ttgtgtggag atatgaagcc 171240
ggggttatgg caataacgtt atcagcacaa gctaaggctt tatcaataaa tgctgtatca 171300
tattggaaag gcgggttcat aataattgta ttgaatttca ttttcttagg ggccttaatg 171360
aattcaaatc cagagaaaca tccgaaagta tcaaatacat aacgggcctt atctgaatca 171420
gttgaaatga ataagatatc ggaagtatca taaccgataa gagataataa tgaaactact 171480
tcaagggatt ctataacac 171499

Claims (12)

1.一种新型噬菌体ΦCJ28(KCCM11466P)，所述新型噬菌体对产肠毒素性大肠杆菌(Enterotoxigenic Escherichia coli)具有特异性杀死能力。
2.一种用于预防或治疗由产肠毒素性大肠杆菌引起的传染病的组合物，所述组合物包括根据权利要求1所述的噬菌体ΦCJ28(KCCM11466P)作为有效成分。
3.根据权利要求2所述的用于预防或治疗由产肠毒素性大肠杆菌引起的传染病的组合物，其中所述传染病是大肠杆菌病。
4.一种抗生素，所述抗生素包括根据权利要求1所述的噬菌体ΦCJ28(KCCM11466P)作为有效成分。
5.一种饲料添加剂，所述饲料添加剂包括根据权利要求1所述的噬菌体ΦCJ28(KCCM11466P)作为有效成分。
6.一种饲料，所述饲料包括根据权利要求5所述的饲料添加剂。
7.一种饮用水添加剂，所述饮用水添加剂包括根据权利要求1所述的噬菌体ΦCJ28(KCCM11466P)作为有效成分。
8.一种饮用水，所述饮用水包括根据权利要求7所述的饮用水添加剂。
9.一种消毒剂，所述消毒剂包括根据权利要求1所述的噬菌体ΦCJ28(KCCM11466P)作为有效成分。
10.一种洗涤剂，所述洗涤剂包括根据权利要求1所述的噬菌体ΦCJ28(KCCM11466P)作为有效成分。
11.一种预防或治疗由产肠毒素性大肠杆菌引起的传染病的方法，所述方法包括如下步骤：
向非人类动物给药根据权利要求1所述的噬菌体ΦCJ28(KCCM11466P)或根据权利要求2所述的组合物。
12.根据权利要求11所述的预防或治疗由产肠毒素性大肠杆菌引起的传染病的方法，其中所述传染病是大肠杆菌病。
CN201580030761.4A 2014-04-10 2015-03-13 新型噬菌体以及包含其的组合物 Active CN107109373B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020140042911A KR101590108B1 (ko) 2014-04-10 2014-04-10 신규 박테리오파지 및 이를 포함하는 조성물
KR10-2014-0042911 2014-04-10
PCT/KR2015/002470 WO2015156509A1 (ko) 2014-04-10 2015-03-13 신규 박테리오파지 및 이를 포함하는 조성물

Publications (2)

Publication Number Publication Date
CN107109373A true CN107109373A (zh) 2017-08-29
CN107109373B CN107109373B (zh) 2020-09-22

Family

ID=54288045

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580030761.4A Active CN107109373B (zh) 2014-04-10 2015-03-13 新型噬菌体以及包含其的组合物

Country Status (10)

Country Link
US (2) US10577590B2 (zh)
EP (1) EP3130669B1 (zh)
JP (1) JP6324536B2 (zh)
KR (1) KR101590108B1 (zh)
CN (1) CN107109373B (zh)
DK (1) DK3130669T3 (zh)
ES (1) ES2732368T3 (zh)
PH (1) PH12016501999A1 (zh)
PL (1) PL3130669T3 (zh)
WO (1) WO2015156509A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112143747A (zh) * 2020-09-09 2020-12-29 昆明理工大学 一种噬菌体裂解酶及其基因、基因重组表达载体与应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101761573B1 (ko) * 2014-12-29 2017-07-26 주식회사 인트론바이오테크놀로지 신규한 장출혈성 대장균 박테리오파지 Ｅｓｃ-ＣＨＰ-1 및 이의 장출혈성 대장균 증식 억제 용도
KR101649851B1 (ko) 2014-12-30 2016-08-30 주식회사 인트론바이오테크놀로지 신규한 시가독소생산 F18형 대장균 박테리오파지 Ｅｓｃ-ＣＯＰ-1 및 이의 시가독소생산 F18형 대장균 증식 억제 용도
KR101761581B1 (ko) * 2014-12-30 2017-07-26 주식회사 인트론바이오테크놀로지 신규한 장침입성 대장균 박테리오파지 Ｅｓｃ-ＣＯＰ-4 및 이의 장침입성 대장균 증식 억제 용도
KR101761578B1 (ko) * 2014-12-30 2017-07-26 주식회사 인트론바이오테크놀로지 신규한 장병원성 대장균 박테리오파지 Ｅｓｃ-ＣＨＰ-2 및 이의 장병원성 대장균 증식 억제 용도
US11058131B2 (en) 2015-04-16 2021-07-13 Kennesaw State University Research And Service Foundation, Inc. Escherichia coli O157:H7 bacteriophage Φ241
US11583565B2 (en) * 2020-04-04 2023-02-21 Intron Biotechnology, Inc. Compositions and methods for inhibiting the proliferation of pathogenic Escherichia coli
US20220105142A1 (en) * 2020-10-01 2022-04-07 Intron Biotechnology, Inc. Compositions and methods for inhibiting the proliferation of pathogenic escherichia coli

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1602353A (zh) * 2001-12-13 2005-03-30 雀巢产品有限公司 分离的噬菌体及其在食品或宠物食品中的用途
WO2013073843A1 (en) * 2011-11-14 2013-05-23 Cj Cheiljedang Corporation Novel isolated bacteriophage having e. coli-specific bactericidal activity and antibacterial composition comprising the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100974185B1 (ko) 2007-08-27 2010-08-05 주식회사 인트론바이오테크놀로지 박테리오파지 유래 용균단백질 작용에 의해 제조된세균파쇄물 및 이를 포함하는 동물질병 예방용 백신 조성물
KR100910961B1 (ko) 2007-09-13 2009-08-05 주식회사 인트론바이오테크놀로지 황색포도상구균의 균막 처치에 효과적인 박테리오파지 또는그것 유래의 용균단백질
KR101101376B1 (ko) * 2009-10-16 2012-01-02 경희대학교 산학협력단 대장균 또는 시겔라속 균에 특이적 사멸능을 갖는 박테리오파지
CN101724607B (zh) * 2009-12-18 2012-05-09 江苏省农业科学院 一种产肠毒素性大肠杆菌的噬菌体ek99-c及其应用
KR101299179B1 (ko) * 2012-04-18 2013-08-22 씨제이제일제당 (주) 신규 박테리오파지 및 이를 포함하는 항균 조성물
KR101381797B1 (ko) 2013-02-27 2014-04-07 씨제이제일제당 (주) 신규 박테리오파지 및 이를 포함하는 항균 조성물
KR101381798B1 (ko) * 2013-02-27 2014-04-07 씨제이제일제당 (주) 신규 박테리오파지 및 이를 포함하는 항균 조성물
KR101381795B1 (ko) * 2013-02-27 2014-04-07 씨제이제일제당 (주) 신규 박테리오파지 및 이를 포함하는 항균 조성물
KR101381793B1 (ko) * 2013-02-27 2014-04-07 씨제이제일제당 (주) 신규 박테리오파지 및 이를 포함하는 항균 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1602353A (zh) * 2001-12-13 2005-03-30 雀巢产品有限公司 分离的噬菌体及其在食品或宠物食品中的用途
WO2013073843A1 (en) * 2011-11-14 2013-05-23 Cj Cheiljedang Corporation Novel isolated bacteriophage having e. coli-specific bactericidal activity and antibacterial composition comprising the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NIDHAM JAMALLUDEEN 等: "Isolation and characterization of nine bacteriophages that lyse O149 enterotoxigenic Escherichia coli", 《VETERINARY MICROBIOLOGY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112143747A (zh) * 2020-09-09 2020-12-29 昆明理工大学 一种噬菌体裂解酶及其基因、基因重组表达载体与应用

Also Published As

Publication number Publication date
EP3130669A4 (en) 2017-12-13
KR101590108B1 (ko) 2016-01-29
ES2732368T3 (es) 2019-11-22
DK3130669T3 (da) 2019-08-12
CN107109373B (zh) 2020-09-22
US20170037380A1 (en) 2017-02-09
EP3130669A1 (en) 2017-02-15
JP2017512487A (ja) 2017-05-25
PH12016501999B1 (en) 2017-01-09
US20200190483A1 (en) 2020-06-18
PH12016501999A1 (en) 2017-01-09
US11785948B2 (en) 2023-10-17
EP3130669B1 (en) 2019-05-08
KR20150117445A (ko) 2015-10-20
BR112016023456A2 (pt) 2017-10-17
PL3130669T3 (pl) 2019-10-31
WO2015156509A1 (ko) 2015-10-15
JP6324536B2 (ja) 2018-05-16
US10577590B2 (en) 2020-03-03

Similar Documents

Publication Publication Date Title
CN107109373B (zh) 新型噬菌体以及包含其的组合物
CN107257853B (zh) 新型肠出血性大肠杆菌噬菌体Esc-CHP-1及其用于抑制肠出血性大肠杆菌增殖的用途
CN107109372A (zh) 新型产气荚膜梭菌噬菌体Clo‑PEP‑1及其用于抑制产气荚膜梭菌增殖的用途
CN107250352A (zh) 新型肠致病性大肠杆菌噬菌体Esc‑CHP‑2及其用于抑制肠致病性大肠杆菌增殖的用途
KR101591789B1 (ko) 신규 박테리오파지 및 이를 포함하는 조성물
PH12015501888B1 (en) Novel bacteriophage and antibacterial composition comprising the same
CN113430174B (zh) 一株高裂解性沙门氏菌噬菌体rdp-sa-19009及其应用
CN110846282B (zh) 耐高温的大肠杆菌噬菌体及其组合物、试剂盒和应用
CN108179136B (zh) 大肠杆菌噬菌体Esc-COP-9及其致病性大肠杆菌增殖抑制用途
KR101993122B1 (ko) 신규한 클렙시엘라 속 세균 특이 박테리오파지 kp1 및 이를 포함하는 항균 조성물
KR102396828B1 (ko) 내열성 박테리오파지 ts3, ts6, ts13 및 이를 포함하는 살모넬라 억제용 조성물
CN108431213B (zh) 新的海豚链球菌噬菌体Str-INP-1及其海豚链球菌增殖抑制用途
KR102016922B1 (ko) 신규한 병원성 대장균 특이 박테리오파지 ec10 및 이를 포함하는 항균 조성물
KR101863593B1 (ko) 신규한 살모넬라균 특이 박테리오파지 sp1 및 이를 포함하는 항균 조성물
KR102379685B1 (ko) 비브리오균을 감염하는 신규한 박테리오파지 vpt02 및 이의 용도
KR102237011B1 (ko) 병원성 살모넬라균 특이 신규 박테리오파지 kfs-sm 및 이를 포함하는 항균 조성물
CN113528463A (zh) 一株裂解性、高效价副溶血弧菌噬菌体rdp-vp-21010及其应用
CN113583974A (zh) 一株裂解性副溶血弧菌噬菌体rdp-vp-21007及其应用
KR102016919B1 (ko) 신규한 살모넬라균 특이 박테리오파지 sc1 및 이를 포함하는 항균 조성물
KR102003795B1 (ko) 신규한 시가톡신 생성 대장균 특이 박테리오파지 ecoh1 및 이를 포함하는 항균 조성물
KR101993124B1 (ko) 신규한 살모넬라균 특이 박테리오파지 sg1 및 이를 포함하는 항균 조성물
KR102586835B1 (ko) 장독소성 대장균에 대한 특이적인 사멸능을 가지는 신규한 박테리오파지 및 이를 포함하는 항균 조성물
KR102193473B1 (ko) 신규한 클렙시엘라 속 세균 특이 박테리오파지 kp12 및 이를 포함하는 항균 조성물
KR102003759B1 (ko) 신규한 살모넬라균 특이 박테리오파지 sh9 및 이를 포함하는 항균 조성물
CN109477075B (zh) 新型支气管败血鲍特菌噬菌体Bor-BRP-1及其抑制支气管败血鲍特菌增殖的用途

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant