CN107080258A - Prepare the fermentation composition and preparation method of the plant enzyme with conditioning collaterals of human rich in nutrition function - Google Patents
Prepare the fermentation composition and preparation method of the plant enzyme with conditioning collaterals of human rich in nutrition function Download PDFInfo
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Abstract
The present invention provides a kind of fermentation composition for preparing the plant enzyme with conditioning collaterals of human rich in nutrition function, is made up of functional oligose, probiotics and Chinese medical extract；0.3~2 part of jujube, 0.3~1.2 part of ginseng, 1~2.5 part of Chinese yam, 1~2 part of Poria cocos, 1~2.5 part of mulberries, 0.1~1.6 part of longan and 0.3~2 part of matrimony vine.The fermentation composition is novel fermentation product, is that the bacterium bag is easy to use for preparing ferment " fermentation bacterium bag ", the industrialized production of suitable all kinds of plant enzymes.
Description
Technical field
The invention belongs to prevent conditioning maintenance product field, more particularly to one kind is prepared with conditioning collaterals of human rich in nutrition
The fermentation composition and preparation method of the plant enzyme of function.
Background technology
Ferment, also known as " enzyme ", ferment participate in all vital movements of human body：Such as think deeply, move, sleep, breathing, anger
Anger, happiness or secretion hormone etc. are all the action results centered on ferment.Plant enzyme is always ferment class product
Best seller.Plant enzyme is by plants such as tens of kinds of different vegetables and fruits, cereal, seaweeds and mushroom classes, through spontaneous fermentation development
Into, the nutrition elite in plant is remained, various ferment, oligosaccharides and a variety of vitamins and the mineral matter needed containing human body, again
Abundant SOD antioxidase compositions can be produced, internal oxidation resistance, and then strengthen immunity is improved.
Existing traditional handicraft and modern crafts to ferment has all done further improvement, while also occurring in that some addition benefits
Health food prepared by the ferment and ferment of raw bacterium.Probiotics fermention fruits and vegetables, can activate the effective efficiency composition in fruits and vegetables, molten
Go out active effect material of more elite.But traditional ferment technique can not be used flexibly on a large scale, or can not be in different ferment
It is convenient in the industrial manufacturing processes of element to use；In order to improve ferment in terms of metabolism, coordinating intestines and stomach function in vivo is promoted
Effect, and adapt to use on a large scale, applicant further improves to the fermentate for preparing ferment, and develops raising ferment
The formula of the function affect of element.
There is physiologically active, not by human body hydrochloric acid in gastric juice, gastric enzyme degraded in addition, functional oligose is a class, do not inhaled in small intestine
Receive, reach the oligosaccharide of big intestines；Oligosaccharide is prebiotics, is the substrate of the growth of probiotics, and with promoting, human body is prebiotic
The physiological functions such as the propagation of bacterium.By the way that probiotics and functional oligose are used in conjunction with, between the two with synergy, energy
Promote the regulatory function to gut flora.Co between probiotics and oligosaccharide, be probiotic in symphysis unit and
Co between prebiotics, they complement each other, and play a role jointly, promote beneficial bacterium growing multiplication, suppress harmful bacteria
Growth；Research shows that both uses can increase the quantity of Bifidobacterium in healthy human faecal mass, but individually take probiotics and have no
This effect.
Based on above-mentioned technology, the artificial feature for improving ferment of application is added with the ferment fermentate of prior art
The traditional Chinese medicine ingredients of effect, enable its ferment prepared effectively to adjust gut flora, strengthen immunity, and have function.
On the other hand, existing ferment bucket, prepares plant enzyme so that plant enzyme using fruit, sugar and water as raw material
It can be prepared in family, it is easy to operate.But also having many weak points, the time prepared by 1. ferment is still longer, Er Qierong
Easily prepare failure；2. made from plant enzyme effect it is indefinite, user can not oneself control prepare effect of plant enzyme, than
Such as there is the plant enzyme of conditioning collaterals of human rich in nutrition function；3. the most nothings of low molecular sugar and polysaccharide in the plants such as fruit
Method is utilized, it is impossible to be converted into the oligosaccharide of given efficacy.For the deficiency, applicant puts forth effort research, and there is shortening ferment to prepare
Time, fermentation composition easy to use and that there is conditioning collaterals of human rich in nutrition function, i.e. ferment bag.
The content of the invention
It is contemplated that at least solving one of technical problem present in prior art.Therefore, one object of the present invention
It is to propose a kind of fermentation composition for preparing the plant enzyme with conditioning collaterals of human rich in nutrition function, the fermentation group
Compound is direct putting type plant enzyme fermenting agent, and probiotics and functional oligose are used in combination the fermentation composition, simultaneously
Add traditional Chinese medicine ingredients, make said composition while with good gut flora regulatory function, can promote small molecular sugar and
Conversion from polysaccharide to oligosaccharide.Plant enzyme prepared by the fermentation composition plays channel recuperating, effect of rich in nutrition, to body
The crowd of the weak deficiency of vital energy has effects that routine servicing.
Technical scheme is as follows：
A kind of fermentation composition for preparing the plant enzyme with conditioning collaterals of human rich in nutrition function, the fementative composition
Thing includes the component of following parts by weight：3~22 parts of functional oligose, 0.1~5 part of probiotics and Chinese medical extract 0.01~
10 parts,
Wherein, the probiotics is the one or more in Bifidobacterium, lactobacillus and streptococcus thermophilus
Freeze-dried powder；
The Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.3~2 part of jujube, 0.3~1.2 part
Ginseng, 1~2.5 part of Chinese yam, 1~2 part of Poria cocos, 1~2.5 part of mulberries, 0.1~1.6 part of longan and 0.3~2 part
Matrimony vine；
The preparation method of the fermentation composition at least comprises the steps：
The fine powder that the functional oligose and Chinese medical extract of predetermined weight number are made is sterilized after mixing, after sterilization with
Probiotics powder agent is uniformly mixed, granulation, and the fermentation composition of powdery is made.
Probiotics and functional oligose reasonable combination are used, and both have mutual promoting action, can be doubled to enteron aisle
The regulatory function of flora, so that the effect based on gut flora plays more preferable strengthen immunity；And the traditional Chinese medicine ingredients added, enter
The effects such as one step realizes prevention or treatment obesity, diabetes, hypertension, high fat of blood or tumour.And powder is made in fermentation composition
Shape, implementation phase formula production, be easy to the later stage direct plunge into use or family oriented use.
Further, functional oligose of the fermentation composition by parts by weight for 5~10 parts, 1~3 part prebiotic
Bacterium and 0.5~1 part of Chinese medical extract composition.
Further, Chinese medical extract is extracted by the raw material of following parts by weight and formed：1~1.5 part of jujube, 0.7~0.9
Part ginseng, 1.6~2 parts of Chinese yam, 1.2~1.5 parts of Poria cocos, 1.5~2 parts of mulberries, 0.9~1.2 part of longan and
0.6~1.2 part of matrimony vine.
In such scheme, the functional oligose is selected from chitosan, xylo-oligosaccharide, kanjak mannan-oligosaccharides, sweet dew
Oligosaccharide, milk ketose, raffinose, soyabean oligosaccharides, FOS, galactooligosaccharide, lactosucrose, konjac mannan sugar,
One or more in trehalose, palatinose and inulin；
Bifidobacterium includes bifidobacterium longum (B.longum), short Bifidobacterium Bifidum (B.breve) (B.breve), bifidobacterium infantis
And the one or more in bifidobacterium lactis (B.ifidobacterium) (B.infantis)；
Lactobacillus includes Lactobacillus rhamnosus (L.rhamnosus), Lactobacillus casei (Lactobacillus
Casei), lactobacillus acidophilus (L.acidophilus), Lactobacillus plantarum (Lactobacillus plantarum), the newborn bar of saliva
Bacterium (Lactobacillus salivarius), Lactobacillus helveticus (Lactobacillus helveticus), Bu Shi lactobacillus
(Lactobacillus buchneri), lactobacillus bulgaricus (Lactobacillus.Bulgaricus), the newborn bar of secondary cheese
One kind or several in bacterium (Lactobacillus paracasei) and lactobacillus reuteri (Lactobacillus reuteri)
Kind.
The preferred scheme of the fermentation composition of the present invention, in addition to the resistant dextrin that parts by weight are 10~20 parts, resistance
Dextrin is used in conjunction with other components, further promotes intestines peristalsis, keeps intestinal health, and control the absorption of grease and sugar.
Further, the functional oligose is mannan-oligosaccharides；
The probiotics is probiotics powder agent, is uniformly mixed by the pulvis of following parts by weight：Bifidobacterium 45~
12~16 parts of 60 parts, 20~25 parts of lactobacillus bulgaricus and Bu Shi lactobacillus, the viable bacteria content of the probiotics powder agent is 2
×108~8 × 108cfu/g；By all kinds of strains of reasonable disposition and consumption, optimize the strain of this patent products'texture, can be effective
Shorten fermentation composition in the time for preparing plant enzyme, and it can be made to prepare the stable plant enzyme of texture.
The source of above-mentioned all kinds of probiotics powder agents：It is the pulvis of commercially available all kinds of strains or by will be commercially available all kinds of
Strain is collected by centrifugation with after washing thalline, drying is prepared into active powder through Liquid Culture.
In another inventive technique scheme, fermentation composition of the invention also includes the yeast that parts by weight are 1~3 part
Bacterium, 1~3 part of acetobacter and 1~5 part of lactic acid bacteria；
The preparation method of the fermentation composition also includes：
(1) softwood is made in the fermentation composition of the powdery of 1/2 amount, is well mixed with the lactic acid bacteria of the parts by weight
Extrusion is carried out afterwards and makes ball, and capsule core is made；
(2) fermentation composition of the powdery of 1/2 amount is mixed with the saccharomycete and acetobacter of the parts by weight
It is even, softwood thing is made, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce
Pellet fermentation composition；
Wherein, the coating solution is by the adjacent benzene for the acroleic acid resin I No. I, 0.1-2 parts that parts by weight are 0.4-10 parts
Dicarboxylate and 0.05-0.2 parts of olive oil add the aqueous dispersion that appropriate purified water is configured to.
It is above-mentioned, it is prepared into the fermentation pill with double-layer structural, outer layer fermentation ball mixing composite bacteria -- saccharomycete and vinegar
Acidfast bacilli, internal layer fermentation ball is mixed with lactic acid bacteria, the step of eliminating later stage multistage inoculation composite bacteria, improves what product was used
Convenience；And the time limit that internal layer pill starts dissolving can effectively be extended by by coating membrane separate between ectonexine, two are reached
Level inoculation fermentation effect, realizes deep layer liquid state fermentation.
The preparation method of the fermentation composition of powdery of the present invention, comprises the following steps：
1) preparation of Chinese medical extract：
The preparation of ginseng extract：Take the ginseng of the parts by weight to crush, cross 60 mesh sieves, be fitted into extraction kettle, with 15-
Flow velocity is passed through CO within 25L/ hours2, add 15% ethanol and make entrainer, be 20-35MPa conditions in 40-60 DEG C of temperature holding, pressure
Lower extraction 3.5-5h, carries out first time separation, collects crude extract, and crude extract goes successively to separating still and carries out secondary separation,
It is that 5-15MPa, temperature are to extract 3.5-5h under the conditions of 40-60 DEG C in pressure, extract is put into the separation of pillar seperator, obtained
Layer grease and the watery thing of lower floor；The watery thing in upper strata is taken, ethyl acetate is added and extracts three times, water layer is collected in separatory funnel layering,
The water layer of three extractions is merged, plus activated carbon impurity elimination, it is concentrated in vacuo, crystallizes, Ginseng Root Powder is made；
The Poria cocos of the parts by weight is crushed, 60 mesh sieves are crossed, Indian Bread is made；By Indian Bread and predetermined weight part
The water of 8 times of weight of jujube, Chinese yam, mulberries, longan, matrimony vine, 4h is kept at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus
The alcohol reflux 4h that 2 times of weight concentrations are 75%, filtering obtains the first filtrate；The water of 3 times of weight of filter residue is added, in temperature 80-90
2.5h is kept at DEG C, 30 DEG C are then cooled to, filtering, the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, low temperature powder
It is broken into fine powder；
Ginseng Root Powder is well mixed with fine powder, the powdered traditional Chinese medicine fine powder of 0.05-0.2mm sizes is ground into；
2) by step 1) in traditional Chinese medicine fine powder mixed with emulsifying agent, water after carry out high speed shear with cutter, form particle
Particle diameter is less than 50 microns of Chinese medicine particulate；
3) by the functional oligose, resistant dextrin and step 2 of predetermined weight number) in Chinese medicine particulate uniformly mix,
Sterilized by heat exchanger, condition is 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed dry
Method comminutor is granulated, and the fermentation composition of powdery is made, and sterile packing is produced.
A further object of the present invention is to provide a kind of plant enzyme for having and nursing one's health collaterals of human rich in nutrition function, is
Formulated for personal or Homemade plant enzyme, the preparation method of the plant enzyme comprises the following steps：
(a) powdery fermentation composition is prepared
(b) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, adds 5
~6L pure water, be well mixed, while add weight be 20~50g the step of (a) prepare fermentation composition to ferment bucket
Interior, capping carries out lucifuge fermentation in fermentation temperature is 28~30 DEG C of environment；
(c) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 5~8d of fermentation, filtering, i.e.,
Obtain plant enzyme.
This method simple and fast, realizes the self-control of various functions plant enzyme, and this method preferably uses ferment bucket and made
Standby, ferment bucket is from market sale；Also the vessel of closed environment can be used to be prepared.
Another preferred scheme of the preparation method of plant enzyme of the present invention, the described method comprises the following steps：
A) fermentation composition of powdery is prepared
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, leather
It is several in Lan Shi lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28
~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not
Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Which is applied to industrial production, with reference to the secondary of plant enzyme stoste first fermentation and fermentation composition of the present invention
Multistage deep layer liquid state fermentation is realized in fermentation；Greatly improve fermentation efficiency.It can release in fermentation process and be enclosed in Chinese medicine or plant
Structure and intracellular nutrients element, retain the original active material of plant, insoluble fibre is changed into solvable in plant
Property dietary fiber improve effect of original plant.
The preferred scheme of the preparation method of another plant enzyme, the use of the fermentation composition also constructed for double-deck pellet
Method, the preparation method comprises the following steps：
I the fermentation composition of pellet) is prepared
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of 1kg weight is added into plant material, and
10L pure water is added, is well mixed, is stood after 1~2d of extraction, high-temperature sterilization is carried out, filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g,
8L water and plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, in closed environment carry out
Fermentation；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, daily ventilation
2-4 times, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
This method simple and fast, realizes the self-control of various functions plant enzyme, and fermentation process is simply deep, once-through operation
Realize second order fermentation, or even multistage fermentation；The plant enzyme rich in nutrition content being prepared into, human absorptivity is high, further carries
Its high effect.
The present invention has the following advantages that compared with prior art：
The fermentation composition that the present invention is developed is novel fermentation product, is for preparing ferment " fermentation bacterium bag ", improveing
Direct addition probiotics prepares the traditional handicraft of plant enzyme, and the bacterium bag is easy to use, can directly with the bacterium bag of pulvis in city
Sold on face, can also put into the industrialized production of all kinds of plant enzymes, realize matching somebody with somebody i.e. with the work(with diversification for plant enzyme
Energy property configuration, is greatly enhanced the preparation efficiency of plant enzyme.
The traditional Chinese medicinal components added in the fermentation composition of the present invention have its physiologically active and health-care effect, while being prebiotic
Bacterium supplements the nutrients in fermentation, and the traditional Chinese medicine ingredients with higher practical value, and the present invention can effectively nurse one's health collaterals of human, benefit
Taste, blood-enrich；Rationally, curative effect is clear and definite, with collaboration for compatibility between probiotics, functional oligose and Chinese medicine each component
The effect of synergy.
The plant enzyme of the present invention meets requirement and the development trend of health products, and plant enzyme can be produced largely to be had to human body
The comprehensive plant enzyme of benefit, metabolism and function adjustment of these enzymes to human body plays an important role, while also containing vitamin, mineral
The nutritional ingredients such as matter, amino acid, organic acid, oligosaccharide.The present invention is fermented by adding above-mentioned fermentation composition, fermentation group
Traditional Chinese medicine ingredients in compound are changed through probiotics, are become small molecule by macromolecular, are easily absorbed by the body；The addition of probiotics can
Toxicity can be decomposed by improving in Chinese medicine taste, fermentation process, realization really has no toxic side effect, while prepared by the fermentation composition
Plant enzyme improves drug effect compared to traditional Chinese medicine, adjusts gut flora.It is the suitable insufficiency of vital energy and blood of plant ferment, in poor health
Crowd is used, and is taken as daily drinks, and lipid-metabolism is improved from the angle effected a permanent cure, and is improved body immunity etc., is realized health care
Purpose.
In addition, the technical process that the direct addition of fermentation composition prepares plant enzyme is simple, it is with low cost, it is easy to accomplish big
Large-scale production, compared to prior art, shortens the time for preparing and fermenting, and safe preparation process.
The source of the Chinese medicine material composition of the present invention：
Jujube：This product is Rhamnaceae jujube jujube Ziziphus jujuba Mill.var.inermis (Bunge)
Rehd. dry mature fruit.
Ginseng：This product is Araliaceae ginseng Panax ginseng C.A.Mey. dry root.
Chinese yam：This product is Dioscoreaceae plant Chinese yam Dioscorea opposita Thunb. dry rhizome.
Poria cocos：This product is On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf dry sclerotia.
Mulberries：This product is moraceae plants mulberry Morus alba L. drying fruit ear.
Longan：Product are Sapindaceae longan platymiscium longan Dimocarpus longan Lour. aril.
Matrimony vine：This product is plant of Solanaceae lycium barbarum Lycium barbarum L. dry mature fruit.
Embodiment
The fermentation composition of embodiment 1
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Mannan-oligosaccharides 80g
Probiotics powder agent：24g, wherein in per g probiotic powders containing 4.5 parts of Bifidobacterium, 2 parts of lactobacillus bulgaricus and
1.6 parts of Bu Shi lactobacillus；
Traditional Chinese medicine ingredients：8g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：1.5 parts of jujube,
1.2 parts of 0.9 part of ginseng, 2 parts of Chinese yam, 1.5 parts of Poria cocos, 2 parts of mulberries, 1.2 parts of longan and matrimony vine；
Resistant dextrin 80g.
Preparation method：
1) preparation of Chinese medical extract：
The preparation of ginseng extract：Take the ginseng of the parts by weight to crush, cross 60 mesh sieves, be fitted into extraction kettle, with 15-
Flow velocity is passed through CO within 25L/ hours2, add 15% ethanol and make entrainer, be 20-35MPa conditions in 40-60 DEG C of temperature holding, pressure
Lower extraction 3.5-5h, carries out first time separation, collects crude extract, and crude extract goes successively to separating still and carries out secondary separation,
It is that 5-15MPa, temperature are to extract 3.5-5h under the conditions of 40-60 DEG C in pressure, extract is put into the separation of pillar seperator, obtained
Layer grease and the watery thing of lower floor；The watery thing in upper strata is taken, ethyl acetate is added and extracts three times, water layer is collected in separatory funnel layering,
The water layer of three extractions is merged, plus activated carbon impurity elimination, it is concentrated in vacuo, crystallizes, Ginseng Root Powder is made；
The Poria cocos of the parts by weight is crushed, 60 mesh sieves are crossed, Indian Bread is made；By Indian Bread and predetermined weight part
The water of 8 times of weight of jujube, Chinese yam, mulberries, longan, matrimony vine, 4h is kept at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus
The alcohol reflux 4h that 2 times of weight concentrations are 75%, filtering obtains the first filtrate；The water of 3 times of weight of filter residue is added, in temperature 80-90
2.5h is kept at DEG C, 30 DEG C are then cooled to, filtering, the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, low temperature powder
It is broken into fine powder；
Ginseng Root Powder is well mixed with fine powder, the powdered traditional Chinese medicine fine powder of 0.05-0.2mm sizes is ground into；
2) by step 1) in Chinese medicine mixed with emulsifying agent, water after carry out high speed shear with cutter, form grain diameter
Chinese medicine particulate less than 50 microns；
3) by the functional oligose, resistant dextrin and step 2 of predetermined weight number) in Chinese medicine particulate uniformly mix,
Sterilized by heat exchanger, condition is 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed dry
Method comminutor is granulated, and the fermentation composition of powdery, sterile packed, every bag of 30g is made.
The fermentation composition of embodiment 2
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Mannan-oligosaccharides 50g
Probiotics powder agent：10g, wherein in per g probiotic powders containing 6 parts of Bifidobacterium, 2.5 parts of lactobacillus bulgaricus and
1.2 parts of Bu Shi lactobacillus；
Traditional Chinese medicine ingredients：5g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：1 part of jujube, people
0.6 part of 0.7 part of ginseng, 1.6 parts of Chinese yam, 1.2 parts of Poria cocos, 1.5 parts of mulberries, 0.9 part of longan and matrimony vine；
Preparation method：
1) preparation of Chinese medical extract：
The preparation of ginseng extract：Take the ginseng of the parts by weight to crush, cross 60 mesh sieves, be fitted into extraction kettle, with 15-
Flow velocity is passed through CO within 25L/ hours2, add 15% ethanol and make entrainer, be 20-35MPa conditions in 40-60 DEG C of temperature holding, pressure
Lower extraction 3.5-5h, carries out first time separation, collects crude extract, and crude extract goes successively to separating still and carries out secondary separation,
It is that 5-15MPa, temperature are to extract 3.5-5h under the conditions of 40-60 DEG C in pressure, extract is put into the separation of pillar seperator, obtained
Layer grease and the watery thing of lower floor；The watery thing in upper strata is taken, ethyl acetate is added and extracts three times, water layer is collected in separatory funnel layering,
The water layer of three extractions is merged, plus activated carbon impurity elimination, it is concentrated in vacuo, crystallizes, Ginseng Root Powder is made；
The Poria cocos of the parts by weight is crushed, 60 mesh sieves are crossed, Indian Bread is made；By Indian Bread and predetermined weight part
The water of 8 times of weight of jujube, Chinese yam, mulberries, longan, matrimony vine, 4h is kept at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus
The alcohol reflux 4h that 2 times of weight concentrations are 75%, filtering obtains the first filtrate；The water of 3 times of weight of filter residue is added, in temperature 80-90
2.5h is kept at DEG C, 30 DEG C are then cooled to, filtering, the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, low temperature powder
It is broken into fine powder；
Ginseng Root Powder is well mixed with fine powder, the powdered traditional Chinese medicine fine powder of 0.05-0.2mm sizes is ground into；
2) by step 1) in traditional Chinese medicine fine powder mixed with emulsifying agent, water after carry out high speed shear with cutter, form particle
Particle diameter is less than 50 microns of Chinese medicine particulate；
3) by the functional oligose and step 2 of predetermined weight number) in Chinese medicine particulate uniformly mix, pass through heat exchanger
Sterilized, condition is 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed dry
Method comminutor is granulated, and the fermentation composition of powdery, sterile packed, every bag of 30g is made.
The fermentation composition of embodiment 3
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Mannan-oligosaccharides 60g
Probiotics powder agent：2g, wherein in per g probiotic powders containing 5.5 parts of Bifidobacterium, 2.3 parts of lactobacillus bulgaricus with
And 1.4 parts of Bu Shi lactobacillus；
Traditional Chinese medicine ingredients：0.2g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：2 parts of jujube,
2 parts of 1.2 parts of ginseng, 2.5 parts of Chinese yam, 2 parts of Poria cocos, 2.5 parts of mulberries, 1.6 parts of longan and matrimony vine；
Resistant dextrin 200g
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 4
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Chitosan 104g, mannan-oligosaccharides 116g；
Probiotics powder agent：50g, wherein containing 5.5 parts of Bifidobacterium, 2.4 parts of Lactobacillus rhamnosus in per g probiotic powders, doing
2.4 parts of 1.3 parts of Lactobacillus paracasei, 1.7 parts of lactobacillus acidophilus and Lactobacillus plantarum；
Traditional Chinese medicine ingredients：100g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Jujube 0.9
1.2 parts of part, 0.6 part of ginseng, 2 parts of Chinese yam, 1.4 parts of Poria cocos, 1.5 parts of mulberries, 0.9 part of longan and matrimony vine.
Preparation method：Prepared according to the preparation method of embodiment 2, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 5
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Xylo-oligosaccharide 83g, soy oligosaccharides Icing Sugar 61g, FOS 56g；
Probiotics powder agent：20g, wherein containing 4 parts of bifidobacterium longum, 1.8 parts of Lactobacillus casei, saliva in per g probiotic powders
2.2 parts of 0.9 part of lactobacillus, 1.5 parts of lactobacillus acidophilus and Lactobacillus plantarum；
Traditional Chinese medicine ingredients：50g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：1.3 parts of jujube,
1 part of 0.7 part of ginseng, 1.9 parts of Chinese yam, 0.5 part of Poria cocos, 0.8 part of mulberries, 1.3 parts of longan and matrimony vine；
Resistant dextrin 300g.
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 6
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Xylo-oligosaccharide 43g, mannan-oligosaccharides 40g, FOS 23g, galactooligosaccharide 22g and
Trehalose 19g；
Probiotics powder agent：10.1g, wherein containing 2.3 parts of bifidobacterium breve, 2 parts of bifidobacterium lactis, mouse in per g probiotic powders
2.4 parts of lactobacillus of Lee's sugar, 1.3 parts of Lactobacillus helveticus, 1 part of Bu Shi lactobacillus, 1.7 parts of lactobacillus bulgaricus and secondary cheese breast
0.9 part of bacillus；
Traditional Chinese medicine ingredients：4.55g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Jujube 0.4
0.8 part of part, 0.5 part of ginseng, 0.9 part of Chinese yam, 1.3 parts of Poria cocos, 1.8 parts of mulberries, 1.4 parts of longan and matrimony vine；
Resistant dextrin 70.5g.
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 7
The prescription of the fermentation composition of the present embodiment is：
The pulvis fermentation composition 32g that embodiment 1 is made；Saccharomycete 1g；Acetobacter 1g；Lactic acid bacteria 1g；Coating solution by
Acroleic acid resin II 20g, diethyl phthalate 5g and olive oil 2.5g add appropriate purified water and prepared；
Preparation method：
(1) softwood is made in the pulvis fermentation composition of 1/2 amount, after being well mixed with the lactic acid bacteria of the parts by weight
Carry out extrusion and make ball, capsule core is made；
(2) the pulvis fermentation composition of 1/2 amount is well mixed with the saccharomycete and acetobacter of the parts by weight,
Softwood thing is made, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce
Pellet fermentation composition, packaging.
Wherein obtained pellet diameters are 4-7mm, a diameter of 2-5mm of capsule core；It is preferred that pellet diameters 5mm, capsule core is a diameter of
2.8mm。
The fermentation composition of embodiment 8
The prescription of the fermentation composition of the present embodiment is：
The pulvis fermentation composition 23.1g that embodiment 3 is made；Saccharomycete 3g；Acetobacter 3g；Lactic acid bacteria 5g；Coating solution
Appropriate purified water is added by acroleic acid resin II 10g, diethyl phthalate 2g and olive oil 0.2g to prepare；
Preparation method：
(2) softwood is made in the pulvis fermentation composition of 1/2 amount, after being well mixed with the lactic acid bacteria of the parts by weight
Carry out extrusion and make ball, capsule core is made；
(2) the pulvis fermentation composition of 1/2 amount is well mixed with the saccharomycete and acetobacter of the parts by weight,
Softwood thing is made, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce
Pellet fermentation composition, packaging.
Wherein obtained pellet diameters are 4-7mm, a diameter of 2-5mm of capsule core；It is preferred that pellet diameters 5mm, capsule core is a diameter of
2.8mm。
The plant enzyme of embodiment 9
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 1；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 2 months, obtains plant enzyme stoste；
Wherein inoculum concentration is 12%；Composite flora is Lactobacillus plantarum, gram lactobacillus, lactobacillus acidophilus and acetic acid
In bacillus；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28
~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not
Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g, and clean section is used.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 10
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 2；
B) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added
In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract
Liquid；
C) mixing and initial fermentation：Add plant of fermentation composition of the weight for 60g step a) preparations into step b)
In thing extract solution, mixing is placed in closed environment, keeps 28 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
D) zymotic fluid carries out after-ripening 7d in closed environment, filtering, produces plant enzyme.
Wherein, plant material selects Kiwi berry 100g, strawberry 90g, hawthorn 40g, mango 220g, carrot 80g, ternip
140g, Chinese cabbage 150g, agaric 80g and mushroom 100g.
Organoleptic parameters：The plant enzyme uniform color, between buff and brown, having, strong fruity and fermentation are fragrant
Gas, mellow in taste, comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 11
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 3；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 1 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, leather
It is several in Lan Shi lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28
~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not
Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Wherein, plant material selects passion fruit 120g, citrus 200g, grape 100g, Chinese yam 50g, pumpkin 220g, celery
40g, water spinach 50g, bean sprouts 50g, sea-tangle 60g, seaweed 40g and asparagus 70g.
Organoleptic parameters：The plant enzyme uniform color, in dark brown, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 12
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 5；
B) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added
In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract
Liquid；
C) mixing and initial fermentation：The fermentation composition for the step a) preparations that weight is 30~60g is added into step b)
Plant extraction liquid in, mixing is placed in closed environment, keeps 30 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
D) zymotic fluid carries out after-ripening 7d in closed environment, filtering, produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 13
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 1；
B) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, addition 5~
6L pure water, is well mixed, while add in fermentation composition to the ferment bucket that weight is prepared for 20~50g step a),
Capping, lucifuge fermentation is carried out in fermentation temperature is 28~30 DEG C of environment；
C) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 4~6d of fermentation, filtering is produced
Plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 14
The plant enzyme of the present embodiment is prepared from by following methods：
I the fermentation composition of pellet) is prepared according to embodiment 7
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of 1kg weight is added into plant material, and
10L pure water is added, is well mixed, is stood after 1~2d of extraction, high-temperature sterilization is carried out, filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g,
8L water and plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, in closed environment carry out
Fermentation；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, daily ventilation
2-4 times, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
Observation to the pellet fermentation composition fermentation process of embodiment 7：Pellet fermentation composition during the fermentation, ball
The outer layer component of grain dissolves rapidly in the solution, and subsequent capsule core dissolving is slow, and coating membrane fades away after about 1-2d, and capsule core is completely molten
Solution.
The fermentation composition of comparative examples 1
The prescription of the fermentation composition of the present embodiment is：：
Functional oligose：Mannan-oligosaccharides 80g
Probiotics powder agent：24g, wherein in per g probiotic powders containing 4.5 parts of Bifidobacterium, 2 parts of lactobacillus bulgaricus and
1.6 parts of Bu Shi lactobacillus；
Resistant dextrin 80g.
Preparation method：
The functional oligose of predetermined weight number, probiotics powder agent, resistant dextrin are uniformly mixed into 10~15min, will
Mixed powder adds dry granulating machine granulation, and the granule of fermentation composition, pack, every bag of 30g is made.
The plant enzyme of comparative examples 2
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared by the fermentation composition of comparative examples 1；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after extraction 2d, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 12%；Composite flora is Lactobacillus plantarum, gram lactobacillus, lactobacillus acidophilus and acetic acid
In bacillus；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28
~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not
Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
The plant enzyme of comparative examples 3
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added
In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract
Liquid；
B) mixing and initial fermentation：It is inoculated with plant extraction liquid of the compound probiotic into step b), mixing is placed in closed
Environment, keeps 30 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
C) zymotic fluid carries out after-ripening 7d in closed environment, takes Partial fermentation liquid to filter, does organoleptic parameters；Continue after-ripening
14d, takes Partial fermentation liquid to filter, does organoleptic parameters.
Wherein, compound probiotic be Bifidobacterium, Lactobacillus rhamnosus, Lactobacillus casei,
Lactobacillus acidophilus and Lactobacillus plantarum；Inoculum concentration is 8% (mass percent)；
Plant material selects apple 500g, soybean 200g and tomato 300g.
The organoleptic parameters of zymotic fluid after 7 days：The plant enzyme color and luster is in bronzing, and tissue mobility is big, entrance slightly has
Stimulation, sweet taste are heavier；The organoleptic parameters of zymotic fluid after 14 days：The plant enzyme uniform color, in bronzing, there is strong
Fruity is not stimulated with fermentation fragrance, mellow in taste, comfortable acid, entrance, and pleasant impression is sweet.Understand, plant prepared by conventional method
Fermentation time of the fermentation time than embodiment 9-11 that ferment needs is longer.
The viable bacteria survival detection of the fermentation composition of test example 1
Fermentation composition prepared by the embodiment of the present invention 1 and embodiment 7, be prepared into sterilized water viable count for 2 ×
108CFU/mL solution to be measured, is saved backup in 4 DEG C；
The 10mL kept the solution to be measured of going bail for is injected into test tube 1, and 10 are diluted to step by step using ten times-8, take 1mL to dilute
The MRS agar mediums that 45 DEG C are cooled to after sterilizing are poured on flat board (sterilizing), shaken up rapidly on flat board by liquid.Again will
The test tube 2 of solution to be measured equipped with 10mL, which is placed in 80-90 DEG C of water-bath, heats 15-25min, takes the solution to be measured after heating to enter
Row ten is diluted to 10 step by step again-8, 1mL dilutions are taken on flat board, and the MRS agar mediums that 45 DEG C are cooled to after sterilizing are poured into
Shake up on flat board (sterilizing) and rapidly.Flat board before finally heating and after heating cultivates 24h under the conditions of 35 DEG C, calculates
Number of viable before and after heating.
As a result show, Viable detection is respectively 88.8% and 87.4%.
The viable bacteria survival detection of the plant enzyme of test example 2
1st, simulate the gastric juice and the resistance test of intestinal juice
100g/L hydrochloric acid 16.4mL plus distilled water diluting is taken, it is respectively 1.5,2.5 and 3.5 to make pH value, take the dilute salt of 100mL
Acid solution, is separately added into 1g pepsins, it is fully dissolved, and obtains simulate the gastric juice, and miillpore filter degerming (0.22 μm) is standby.Take
Potassium dihydrogen phosphate 6.8g, the 500mL that adds water makes dissolving, and pH value is adjusted to 6.8 with 0.1moL/L sodium hydroxide solutions；Separately take tryptose
Enzyme 10g, the 100mL that adds water makes dissolving, after two liquid are mixed, is diluted with water to 1000ml, obtains simulated intestinal fluid, miillpore filter is degerming
(0.22 μm) is standby.
Embodiment 9 that 1mL is kept and the plant enzyme solution of embodiment 14 is taken to be added in 9mL simulate the gastric juice (i.e. ten
Dilute step by step again), and rapid fully mixing on the oscillator, it is subsequently placed in 30-45 DEG C of quiescent culture 2-4h.Respectively 1h, 2h,
Nutrient solution is taken out when 3h, 4h and remaining viable count is counted immediately, is compared, as a result shows with former viable count, viable bacteria is deposited
Motility rate is respectively 98.2% and 98.4%.Then each 1mL of nutrient solution that different time is digested in simulated gastric fluid is taken, is inoculated with respectively
In 9mL pH value in 6.8 simulated intestinal fluid, to be placed in 30-45 DEG C of quiescent culture 2-4h, and sample, survey in 0,3,6,24h respectively
Its fixed viable count, is compared, it is 99% as a result to show Viable detection with former viable count.
The pharmacodynamics animal experiment of the plant enzyme rich in nutrition of test example 3
1st, experimental animal
Kunming mouse, 22 ± 4g of body weight, male and female half and half, female mice is without pregnant.By animal effect experiment conventional method,
Build Lost blood anemia mouse model, hemolytic hydracetin-induced anemia mice model.
2nd, to the influence of Lost blood anemia mouse
2.1 medicines and packet
Mouse is randomly divided into 9 groups, every group 11, packet situation is：
Group 1：The plant enzyme of gavage embodiment 9；
Group 2：The plant enzyme of gavage embodiment 11；
Group 3：The plant enzyme of gavage embodiment 12；
Group 4：The plant enzyme of gavage embodiment 13；
Group 5：The plant enzyme of gavage embodiment 14；
Group 6：The plant enzyme of gavage comparative examples 2；
Group 7：The plant enzyme of gavage comparative examples 3；
Group 8：The ferrous sulfate of the capacity such as gavage；
Group 9：Blank control group, the physiological saline of the capacity such as gavage；
Mouse is taken twice daily, each 10ml, is taken after dilution.
2.2 result：
Blank control group hemoglobin test the 8th day than experiment before significantly reduce (P ﹤ 0.01), experiment the 10th day it is extensive
It is multiple, but be still significantly lower than before experiment (P ﹤ 0.01)；Test the 8th day, the hemoglobin pole that 1 mouse is organized in the present invention is significantly higher than
Blank control group (P ﹤ 0.01), and it is suitable with ferrous sulfate group；The hemoglobin of mouse is also significantly greater than blank in group 2~5,7
Compare (P ﹤ 0.05), the hemoglobin of mouse is without significantly improving in group 6；Test the 10th day, the blood red egg of mouse in group 1 and group 5
It is white to be all remarkably higher than blank control (P ﹤ 0.01), and better than ferrous sulfate group (P ﹥ 0.05).
3rd, to the influence of Lost blood anemia mouse
3.1 medicines and packet
Mouse is randomly divided into 9 groups, every group 11, packet situation is：
Group 1：The plant enzyme of gavage embodiment 9；
Group 2：The plant enzyme of gavage embodiment 11；
Group 3：The plant enzyme of gavage embodiment 12；
Group 4：The plant enzyme of gavage embodiment 13；
Group 5：The plant enzyme of gavage embodiment 14；
Group 6：The plant enzyme of gavage comparative examples 2；
Group 7：The plant enzyme of gavage comparative examples 3；
Group 8：Gavage GUIPI WAN；
Group 9：Blank control group, the physiological saline of the capacity such as gavage；
It is taken twice daily, each 10ml takes after dilution.
3.2 result：
Acetylphenylhydrazine (APH) is subcutaneously injected, and each group animal hematoglobin value is gradually reduced afterwards, second of hypodermic injection second
Acyl phenylhydrazine (APH) afterwards hemoglobin highly significant less than experiment before level；With the extension of administration time, each group hemoglobin
Value gradually shows difference, tests the 7th day, and very significantly (P ﹤ 0.01) is higher than blank to the hemoglobin of group 1, group 4 and group 5
Control group, and it is suitable with GUIPI WAN group, and group 6 is without significant change；Test the 9th, 10 days groups 1~5,7 Hemoglobin Values show very much
Write ground and be higher than blank control group, compared with the clinical dosage of identical multiple, group 1 and group 5 are significantly better than GUIPI WAN (P ﹤ 0.05).
4th, experiment conclusion：On Lost blood anemia mouse model, Chinese medicine preparation of the present invention, which is shown, significantly increases blood red
The effect of albumen；On hemolytic hydracetin-induced anemia mice model, Chinese medicine preparation of the present invention shows the work of obvious increase hemoglobin
With.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not
In the case of departing from the principle and objective of the present invention a variety of change, modification, replacement and modification can be carried out to these embodiments, this
The scope of invention is limited by claim and its equivalent.
Claims (10)
1. a kind of fermentation composition for preparing the plant enzyme with conditioning collaterals of human rich in nutrition function, it is characterised in that
The fermentation composition is direct putting type plant enzyme fermenting agent, and the fermentation composition includes the component of following parts by weight：Work(
0.01~10 part of 3~22 parts of energy property oligosaccharide, 0.1~5 part of probiotics and Chinese medical extract,
Wherein, the probiotics is one or more of jellies in Bifidobacterium, lactobacillus and streptococcus thermophilus
Dry powder；
The Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.3~2 part of jujube, 0.3~1.2 part of ginseng,
1~2.5 part of Chinese yam, 1~2 part of Poria cocos, 1~2.5 part of mulberries, 0.1~1.6 part of longan and 0.3~2 part of Chinese holly
Qi；
The preparation method of the fermentation composition at least comprises the steps：
The fine powder that the functional oligose and Chinese medical extract of predetermined weight number are made is sterilized after mixing, after sterilization with it is prebiotic
Bacteria powder is uniformly mixed, granulation, and the fermentation composition of powdery is made.
2. fermentation composition as claimed in claim 1, it is characterised in that the fermentation composition is 5~10 by parts by weight
The functional oligose, 1~3 part of probiotics and 0.5~1 part of Chinese medical extract composition of part.
3. fermentation composition as claimed in claim 1, it is characterised in that the Chinese medical extract by following parts by weight raw material
Extraction is formed：1~1.5 part of jujube, 0.7~0.9 part of ginseng, 1.6~2 parts of Chinese yam, 1.2~1.5 parts of Poria cocos, 1.5
~2 parts of mulberries, 0.9~1.2 part of longan and 0.6~1.2 part of matrimony vine；
The functional oligose is selected from chitosan, xylo-oligosaccharide, kanjak mannan-oligosaccharides, mannan-oligosaccharides, milk ketose, cotton
Seed sugar, soyabean oligosaccharides, FOS, galactooligosaccharide, lactosucrose, konjac mannan sugar, trehalose, palatinose and
One or more in inulin；
The Bifidobacterium includes one kind in bifidobacterium longum, bifidobacterium breve, bifidobacterium infantis and bifidobacterium lactis
Or it is several；
The lactobacillus include Lactobacillus rhamnosus, Lactobacillus casei, lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus salivarius,
Lactobacillus helveticus, Bu Shi lactobacillus, lactobacillus bulgaricus, lactobacillus paracasei and one kind or several in lactobacillus reuteri
Kind.
4. fermentation composition as claimed in claim 1, it is characterised in that it is 10 that the fermentation composition, which also includes parts by weight,
~20 parts of resistant dextrin.
5. fermentation composition as claimed in claim 4, it is characterised in that the functional oligose is mannan-oligosaccharides；
The probiotics is probiotics powder agent, is uniformly mixed by the pulvis of following parts by weight：45~60 parts of Bifidobacterium,
12~16 parts of 20~25 parts of lactobacillus bulgaricus and Bu Shi lactobacillus, the viable bacteria content of the probiotics powder agent is 2 × 108
~8 × 108cfu/g。
6. such as fermentation composition according to any one of claims 1 to 5, it is characterised in that the fermentation composition also includes
Parts by weight are 1~3 part of saccharomycete, 1~3 part of acetobacter and 1~5 part of lactic acid bacteria；
The preparation method of the fermentation composition also includes：
(1) softwood is made in the fermentation composition of the powdery of 1/2 amount, is well mixed with the lactic acid bacteria of the parts by weight laggard
Row extrusion makes ball, and capsule core is made；
(2) fermentation composition of the powdery of 1/2 amount is well mixed with the saccharomycete and acetobacter of the parts by weight, made
It is standby into softwood thing；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce pellet
Fermentation composition；
Wherein, the coating solution is by the phthalic acid for the acroleic acid resin No. II, 0.1-2 parts that parts by weight are 0.4-10 parts
Diethylester and 0.05-0.2 parts of olive oil add the aqueous dispersion that appropriate purified water is configured to.
7. a kind of preparation method of fermentation composition as claimed in claim 4, it is characterised in that methods described includes following step
Suddenly：
1) preparation of Chinese medical extract：
The preparation of ginseng extract：Take the ginseng of the parts by weight to crush, cross 60 mesh sieves, be fitted into extraction kettle, it is small with 15-25L/
When flow velocity be passed through CO2, add 15% ethanol and make entrainer, extracted under the conditions of 40-60 DEG C of temperature holding, pressure are 20-35MPa
3.5-5h, carries out first time separation, collects crude extract, crude extract goes successively to separating still and carries out secondary separation, in pressure
It is to extract 3.5-5h under the conditions of 40-60 DEG C for 5-15MPa, temperature, extract is put into the separation of pillar seperator, upper strata oily is obtained
The watery thing of thing and lower floor；The watery thing in upper strata is taken, ethyl acetate is added and extracts three times, separatory funnel layering collects water layer, by three times
The water layer of extraction merges, plus activated carbon impurity elimination, is concentrated in vacuo, crystallizes, Ginseng Root Powder is made；
The Poria cocos of the parts by weight is crushed, 60 mesh sieves are crossed, Indian Bread is made；By the big of Indian Bread and predetermined weight part
The water of 8 times of weight of jujube, Chinese yam, mulberries, longan, matrimony vine, keeps 4h at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus 2
Times weight concentration is 75% alcohol reflux 4h, and filtering obtains the first filtrate；The water of 3 times of weight of filter residue is added, in temperature 80-90
2.5h is kept at DEG C, 30 DEG C are then cooled to, filtering, the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, low temperature powder
It is broken into fine powder；
Ginseng Root Powder is well mixed with fine powder, the powdered traditional Chinese medicine fine powder of 0.05-0.2mm sizes is ground into；
2) by step 1) in traditional Chinese medicine fine powder mixed with emulsifying agent, water after carry out high speed shear with cutter, form grain diameter
Chinese medicine particulate less than 50 microns；
3) by the functional oligose, resistant dextrin and step 2 of predetermined weight number) in Chinese medicine particulate uniformly mix, pass through
Heat exchanger is sterilized, and condition is 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, and adding dry method after being well mixed makes
Grain machine granulation, is made the fermentation composition of powdery, sterile packing is produced.
8. there is the preparation of the plant enzyme of conditioning collaterals of human rich in nutrition function any one of a kind of claim 1-5
Method, it is characterised in that the described method comprises the following steps：
(a) powdery fermentation composition is prepared
(b) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, adds 5~6L
Pure water, be well mixed, at the same add weight be 20~50g the step of (a) prepare fermentation composition to ferment bucket in, envelope
Lid, lucifuge fermentation is carried out in fermentation temperature is 28~30 DEG C of environment；
(c) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 5~8d of fermentation, filtering produces plant
Thing ferment.
9. there is the preparation of the plant enzyme of conditioning collaterals of human rich in nutrition function any one of a kind of claim 1-5
Method, it is characterised in that the described method comprises the following steps：
A) fermentation composition of powdery is prepared
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight is added into plant material
10L pure water, is well mixed, and stands after 1~2d of extraction, carries out high-temperature sterilization, and filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carries out lucifuge
Fermentation 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, gram
It is several in lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water with
And plant material 0.5kg, add 150ml plant enzyme stoste fermented in closed environment, fermentation temperature be 28~30
DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is constant, after
Supervention ferment 3-4d, filtering, produces plant enzyme.
10. having the preparation method of the plant enzyme of conditioning collaterals of human rich in nutrition function described in a kind of claim 6, it is special
Levy and be, the described method comprises the following steps：
I the fermentation composition of pellet) is prepared
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight is added into plant material
10L pure water, is well mixed, and stands after 1~2d of extraction, carries out high-temperature sterilization, and filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water
And plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, sent out in closed environment
Ferment；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, and ventilate 2-4 daily
It is secondary, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757042A (en) * | 2009-05-25 | 2010-06-30 | 北京诚创康韵医药科技有限公司 | Probiotic pellet preparation and preparing method thereof |
| CN104152354A (en) * | 2013-05-14 | 2014-11-19 | 仙农生物科技(上海)有限公司 | Compound probiotics as well as production process and application thereof to leavening agent |
| CN105112329A (en) * | 2015-08-26 | 2015-12-02 | 上海普乐拜格健康科技有限公司 | Method for preparing special microbial preparations for homemade 'fruit and vegetable enzymes', products of method and application of products |
| CN106174485A (en) * | 2016-07-11 | 2016-12-07 | 佛山市朗达信息科技有限公司 | There is the enzyme composition of kidney-reinforcing Yang strengthening effect, effervescent tablet and preparation method |
-
2017
- 2017-04-11 CN CN201710233647.2A patent/CN107080258A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757042A (en) * | 2009-05-25 | 2010-06-30 | 北京诚创康韵医药科技有限公司 | Probiotic pellet preparation and preparing method thereof |
| CN104152354A (en) * | 2013-05-14 | 2014-11-19 | 仙农生物科技(上海)有限公司 | Compound probiotics as well as production process and application thereof to leavening agent |
| CN105112329A (en) * | 2015-08-26 | 2015-12-02 | 上海普乐拜格健康科技有限公司 | Method for preparing special microbial preparations for homemade 'fruit and vegetable enzymes', products of method and application of products |
| CN106174485A (en) * | 2016-07-11 | 2016-12-07 | 佛山市朗达信息科技有限公司 | There is the enzyme composition of kidney-reinforcing Yang strengthening effect, effervescent tablet and preparation method |
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| CN108936632A (en) * | 2018-08-08 | 2018-12-07 | 深圳极醇健康产业股份有限公司 | A kind of krill fat capsule and preparation method thereof |
| CN108785331B (en) * | 2018-08-10 | 2020-07-17 | 泰安大凡神农制药有限公司 | Composition with qi and blood tonifying function and preparation method and application thereof |
| CN108785331A (en) * | 2018-08-10 | 2018-11-13 | 泰安大凡神农生物有限公司 | It is a kind of that there is qi-blood tonifying composition and its preparation method and application |
| CN109380733A (en) * | 2018-09-13 | 2019-02-26 | 深圳极醇健康产业股份有限公司 | A kind of probiotics powder agent and preparation method thereof |
| CN109394964A (en) * | 2018-10-22 | 2019-03-01 | 湖北麦克森生物技术有限公司 | A kind of pharmaceutical composition of recuperating qi-blood and preparation method thereof |
| CN111066984A (en) * | 2019-11-21 | 2020-04-28 | 湖南尚道生物科技有限公司 | A compound health beverage with blood replenishing and qi invigorating effects, and its preparation method |
| CN112515069A (en) * | 2020-11-04 | 2021-03-19 | 百色学院 | Medicinal and edible Chinese herbal medicine fermented beverage for improving female immunity and preparation method thereof |
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Application publication date: 20170822 |