CN107927780A - Probiotics soft capsule containing natural extract - Google Patents
Probiotics soft capsule containing natural extract Download PDFInfo
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- CN107927780A CN107927780A CN201711211264.1A CN201711211264A CN107927780A CN 107927780 A CN107927780 A CN 107927780A CN 201711211264 A CN201711211264 A CN 201711211264A CN 107927780 A CN107927780 A CN 107927780A
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- probiotics
- bifidobacterium
- lactobacillus
- soft capsule
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- 239000000284 extract Substances 0.000 title claims abstract description 41
- 239000006041 probiotic Substances 0.000 title claims abstract description 39
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 39
- 239000007901 soft capsule Substances 0.000 title claims abstract description 25
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 26
- 239000000843 powder Substances 0.000 claims abstract description 26
- 241001147746 Lactobacillus delbrueckii subsp. lactis Species 0.000 claims abstract description 23
- 235000020710 ginseng extract Nutrition 0.000 claims abstract description 19
- 241000193830 Bacillus <bacterium> Species 0.000 claims abstract description 15
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 13
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 13
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 13
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 13
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 13
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 13
- 239000011718 vitamin C Substances 0.000 claims abstract description 13
- 241001608472 Bifidobacterium longum Species 0.000 claims abstract description 12
- 244000199885 Lactobacillus bulgaricus Species 0.000 claims abstract description 12
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 claims abstract description 12
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 claims abstract description 12
- 108010053775 Nisin Proteins 0.000 claims abstract description 12
- 229940009291 bifidobacterium longum Drugs 0.000 claims abstract description 12
- 229940004208 lactobacillus bulgaricus Drugs 0.000 claims abstract description 12
- 239000004309 nisin Substances 0.000 claims abstract description 12
- 235000010297 nisin Nutrition 0.000 claims abstract description 12
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims abstract description 11
- 241000186012 Bifidobacterium breve Species 0.000 claims abstract description 11
- 229920002472 Starch Polymers 0.000 claims abstract description 11
- 235000019698 starch Nutrition 0.000 claims abstract description 11
- 239000008107 starch Substances 0.000 claims abstract description 11
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims abstract description 10
- 241000186016 Bifidobacterium bifidum Species 0.000 claims abstract description 6
- 229940002008 bifidobacterium bifidum Drugs 0.000 claims abstract description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 9
- 241000208340 Araliaceae Species 0.000 claims description 8
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 8
- 235000008434 ginseng Nutrition 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 241000186000 Bifidobacterium Species 0.000 claims description 4
- 229920002774 Maltodextrin Polymers 0.000 claims description 4
- 239000005913 Maltodextrin Substances 0.000 claims description 4
- 229940035034 maltodextrin Drugs 0.000 claims description 4
- 238000002137 ultrasound extraction Methods 0.000 claims description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 5
- 230000000050 nutritive effect Effects 0.000 abstract description 3
- 241000894007 species Species 0.000 abstract description 3
- 239000002775 capsule Substances 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 5
- 230000000968 intestinal effect Effects 0.000 description 5
- 241000186660 Lactobacillus Species 0.000 description 3
- 229940039696 lactobacillus Drugs 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 241000186046 Actinomyces Species 0.000 description 1
- 241000193171 Clostridium butyricum Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 241000933856 bacterium 8 Species 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 235000021393 food security Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000007149 gut brain axis pathway Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to a kind of probiotics soft capsule containing natural extract, belong to health product technology field.The soft capsule includes the component of following parts by weight：5~10 parts of ginseng extract, 1~5 part of Rhizoma Atractylodis Macrocephalae extract, 0.01~0.1 part of vitamin C, 5~15 parts of oligofructose, 3~8 parts of microcrystalline cellulose, 1~10 part of Freeze-dry Powder of Probioctics, 10~30 parts of starch.The Freeze-dry Powder of Probioctics contains following probiotics：Bifidobacterium longum, bifidobacterium bifidum, bifidobacterium adolescentis, bifidobacterium breve, lactobacillus lactis number, Gel Lactobacillus lactis number, nisin number, lactobacillus bulgaricus, Lactobacillus rhamnosus and hay bacillus.The capsule is rich in a variety of probiotics species beneficial to human body, and is added with other nutritive and health protection components, and effect is more.
Description
Technical field
The present invention relates to health product technical field, has and is related to a kind of probiotics soft capsule containing natural extract.
Background technology
Probiotics is a kind of active microorganism beneficial to host, is to be colonized in human body intestinal canal, in reproductive system, can produce
Definite health efficacy is so as to the active beneficial microorganism general name for improving host's microecological balance, playing beneficial effect.Human body, move
Beneficial bacterium or fungi mainly have in object：Clostridium butyricum, lactobacillus, Bifidobacterium, actinomyces, saccharomycete etc..Generation at present
The hot product studied in boundary, mainly more than all kinds of microorganism groups into composite reactive probiotics, it is widely used in biology
Engineering, industrial or agricultural, food security and life and health field.But existing composite reactive probiotics mainly has following two lack
Point：First, only containing a few probiotics species, covering scope is small；Second, do not add containing only profitable probliotics in product
Add other nutritive and health protection components, effect is few.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of probiotics soft capsule containing natural extract, which is rich in
A variety of probiotics species beneficial to human body, and other nutritive and health protection components are added with, effect is more.
In order to solve the above technical problems, the present invention uses following technical scheme：
A kind of probiotics soft capsule containing natural extract, its soft capsule include the component of following parts by weight：Ginseng carries
Take 5~10 parts of thing, 1~5 part of Rhizoma Atractylodis Macrocephalae extract, 0.01~0.1 part of vitamin C, 5~15 parts of oligofructose, microcrystalline cellulose 3
~8 parts, 1~10 part of Freeze-dry Powder of Probioctics, 10~30 parts of starch；
The Freeze-dry Powder of Probioctics contains the probiotics of following quantity：Bifidobacterium longum 4 × 108~6 × 108A/g, it is not tally
Bifidobacterium 5 × 106~1 × 107A/g, bifidobacterium adolescentis 2 × 105~5 × 105A/g, bifidobacterium breve 3 × 106~6 ×
106A/g, lactobacillus lactis number 1 × 105~5 × 105A/g, Gel Lactobacillus lactis number 1 × 107~3 × 107A/g, nisin
Number 2 × 106~5 × 106A/g, lactobacillus bulgaricus 1 × 105~3 × 105A/g, Lactobacillus rhamnosus 1 × 105~3 ×
105A/g, hay bacillus 1 × 107~2.5 × 107A/g.
In above-mentioned technical proposal：
Preferably, several more specifically component proportions are provided here.First, the parts by weight of the component can be：People
5 parts of conopsea extraction, 3 parts of Rhizoma Atractylodis Macrocephalae extract, 0.1 part of vitamin C, 5 parts of oligofructose, 6 parts of microcrystalline cellulose, probiotics freeze
10 parts of powder, 10 parts of starch.
Second, the parts by weight of the component can be：8 parts of ginseng extract, 5 parts of Rhizoma Atractylodis Macrocephalae extract, vitamin C 0.01
Part, 10 parts of oligofructose, 8 parts of microcrystalline cellulose, 1 part of Freeze-dry Powder of Probioctics, 20 parts of starch.
Third, the parts by weight of the component can be：10 parts of ginseng extract, 1 part of Rhizoma Atractylodis Macrocephalae extract, vitamin C 0.05
Part, 15 parts of oligofructose, 3 parts of microcrystalline cellulose, 8 parts of Freeze-dry Powder of Probioctics, 30 parts of starch.
Preferably, the proportioning of several more specifically probiotics can also be provided here.First, the Freeze-dry Powder of Probioctics
The probiotics of following quantity can be contained：Bifidobacterium longum 4 × 108A/g, bifidobacterium bifidum 8 × 107A/g, youth bifid
Bacillus 5 × 105A/g, bifidobacterium breve 3 × 106A/g, lactobacillus lactis number 2.5 × 105A/g, Gel Lactobacillus lactis number 3 ×
107A/g, nisin number 2 × 106A/g, lactobacillus bulgaricus 2.5 × 105A/g, Lactobacillus rhamnosus 3 × 105A/
G, hay bacillus 1 × 107。
Second, the Freeze-dry Powder of Probioctics can contain the probiotics of following quantity：Bifidobacterium longum 5.3 × 108A/g,
Bifidobacterium bifidum 1 × 107A/g, bifidobacterium adolescentis 2 × 105A/g, bifidobacterium breve 4.8 × 106A/g, lactic acid breast bar
Bacterium number 5 × 105A/g, Gel Lactobacillus lactis number 1 × 107A/g, nisin number 3 × 106A/g, lactobacillus bulgaricus 3 ×
105A/g, Lactobacillus rhamnosus 1 × 105A/g, hay bacillus 1.5 × 107A/g.
Third, the Freeze-dry Powder of Probioctics can contain the probiotics of following quantity：Bifidobacterium longum 6 × 108A/g, two
Discrimination Bifidobacterium 5 × 106A/g, bifidobacterium adolescentis 3.4 × 105A/g, bifidobacterium breve 6 × 106A/g, lactobacillus lactis
Number 1 × 105A/g, Gel Lactobacillus lactis number 1.8 × 107A/g, nisin number 5 × 106A/g, lactobacillus bulgaricus 1 ×
105A/g, Lactobacillus rhamnosus 2.2 × 105A/g, hay bacillus 2.5 × 107A/g.
Wherein, the preparation method of the ginseng extract is：By ginseng under the conditions of -10~-40 DEG C, freeze-drying 12~
24h, is then crushed to 20~40 mesh, is immersed in the ethanol solution that volumetric concentration is 60%~95% after 5~10h, then be placed in
In ultrasonic wave extraction instrument, 40~60min of ultrasonic extraction under 220~240W power is filtered, and filtrate subtracts under the conditions of 50~60 DEG C
Pressure concentration, medicinal extract drying, up to ginseng extract.
Wherein, the preparation method of the Rhizoma Atractylodis Macrocephalae extract is：The Rhizoma Atractylodis Macrocephalae after crushing is added in the water of 5~10 times of weight,
Decoct 3~4 times, every time 1~3 it is small when, filtering, merging filtrate；The filtrate decompression of merging is condensed into the 3/4~1/2 of original volume,
The citric acid, 1%~1.5% protein sugar, 1.5%~2.5% malt paste of its weight 0.1%~1% are added in concentrate
Essence, spray drying, gained particle is Rhizoma Atractylodis Macrocephalae extract.
Beneficial effects of the present invention are：
The soft capsule clinical practice compatibility of the present invention has plurality kinds of health care component, its ginseng extract contained, which has, adjusts human body
Immune function, improves human-body fatigue, adjusts the effect of brain-gut axis balances；Its Rhizoma Atractylodis Macrocephalae extract contained has strengthening the spleen and replenishing qi, adjusts
The effect of human body intestinal canal, improvement abdominal distention diarrhea；The Freeze-dry Powder of Probioctics added contain up to ten kinds it is beneficial to human body prebiotic
Bacterium, and the rich content of every kind of probiotics, reasonable mixture ratio, can effectively adjust human body intestinal canal, treatment constipation, diarrhea etc.；Tie again
Close with vitamin C, oligofructose and microcrystalline cellulose, which can also provide multiple beneficial component for human body intestinal canal, beneficial to intestines
The reparation of mucous membrane, the adjusting of function of intestinal canal.
Embodiment
With reference to specific embodiment for instruction and explanation of the present invention.
Embodiment 1
Probiotics soft capsule containing natural extract, its soft capsule include the component of following parts by weight：Ginseng extract 5
Part, 3 parts of Rhizoma Atractylodis Macrocephalae extract, 0.1 part of vitamin C, 5 parts of oligofructose, 6 parts of microcrystalline cellulose, 10 parts of Freeze-dry Powder of Probioctics, form sediment
10 parts of powder.
The Freeze-dry Powder of Probioctics contains the probiotics of following quantity：Bifidobacterium longum 4 × 108A/g, not tally bifid bar
Bacterium 8 × 107A/g, bifidobacterium adolescentis 5 × 105A/g, bifidobacterium breve 3 × 106A/g, lactobacillus lactis number 2.5 × 105
A/g, Gel Lactobacillus lactis number 3 × 107A/g, nisin number 2 × 106A/g, lactobacillus bulgaricus 2.5 × 105A/g, mouse
Lee's sugar lactobacillus 3 × 105A/g, hay bacillus 1 × 107。
The preparation method of the ginseng extract is：By ginseng under the conditions of -10 DEG C, 20h is freeze-dried, is then crushed to
40 mesh, are immersed in the ethanol solution that volumetric concentration is 60% after 8h, then are placed in ultrasonic wave extraction instrument, surpass under 240W power
Sound extracts 40min, filtering, and filtrate is concentrated under reduced pressure under the conditions of 55 DEG C, medicinal extract drying, up to ginseng extract.
The preparation method of the Rhizoma Atractylodis Macrocephalae extract is：The Rhizoma Atractylodis Macrocephalae after crushing is added in the water of 10 times of weight, decocted 3 times,
Every time 2 it is small when, filtering, merging filtrate；The filtrate decompression of merging is condensed into the 1/2 of original volume, its weight is added in concentrate
0.1% citric acid, 1.2% protein sugar, 2.5% maltodextrin, spray drying, gained particle is Rhizoma Atractylodis Macrocephalae extract.
Embodiment 2
Probiotics soft capsule containing natural extract, its soft capsule include the component of following parts by weight：Ginseng extract 8
Part, 5 parts of Rhizoma Atractylodis Macrocephalae extract, 0.01 part of vitamin C, 10 parts of oligofructose, 8 parts of microcrystalline cellulose, 1 part of raw bacterium freeze-dried powder, starch
20 parts.
The Freeze-dry Powder of Probioctics contains the probiotics of following quantity：Bifidobacterium longum 5.3 × 108A/g, not tally bifid
Bacillus 1 × 107A/g, bifidobacterium adolescentis 2 × 105A/g, bifidobacterium breve 4.8 × 106A/g, lactobacillus lactis number 5 ×
105A/g, Gel Lactobacillus lactis number 1 × 107A/g, nisin number 3 × 106A/g, lactobacillus bulgaricus 3 × 105A/g,
Lactobacillus rhamnosus 1 × 105A/g, hay bacillus 1.5 × 107A/g.
The preparation method of the ginseng extract is：By ginseng under the conditions of -20 DEG C, 24h is freeze-dried, is then crushed to
20 mesh, are immersed in the ethanol solution that volumetric concentration is 75% after 10h, then are placed in ultrasonic wave extraction instrument, under 220W power
Ultrasonic extraction 50min, filtering, filtrate are concentrated under reduced pressure under the conditions of 60 DEG C, medicinal extract drying, up to ginseng extract.
The preparation method of the Rhizoma Atractylodis Macrocephalae extract is：The Rhizoma Atractylodis Macrocephalae after crushing is added in the water of 5 times of weight, decocted 4 times,
Every time 3 it is small when, filtering, merging filtrate；The filtrate decompression of merging is condensed into the 3/4 of original volume, its weight is added in concentrate
0.8% citric acid, 1.5% protein sugar, 1.5% maltodextrin, spray drying, gained particle is Rhizoma Atractylodis Macrocephalae extract.
Embodiment 3
Probiotics soft capsule containing natural extract, its soft capsule include the component of following parts by weight：Ginseng extract
10 parts, 1 part of Rhizoma Atractylodis Macrocephalae extract, 0.05 part of vitamin C, 15 parts of oligofructose, 3 parts of microcrystalline cellulose, 8 parts of Freeze-dry Powder of Probioctics,
30 parts of starch.
The Freeze-dry Powder of Probioctics contains the probiotics of following quantity：Bifidobacterium longum 6 × 108A/g, not tally bifid bar
Bacterium 5 × 106A/g, bifidobacterium adolescentis 3.4 × 105A/g, bifidobacterium breve 6 × 106A/g, lactobacillus lactis number 1 × 105
A/g, Gel Lactobacillus lactis number 1.8 × 107A/g, nisin number 5 × 106A/g, lactobacillus bulgaricus 1 × 105A/g, mouse
Lee's sugar lactobacillus 2.2 × 105A/g, hay bacillus 2.5 × 107A/g.
The preparation method of the ginseng extract is：By ginseng under the conditions of -40 DEG C, 12h is freeze-dried, is then crushed to
30 mesh, are immersed in the ethanol solution that volumetric concentration is 95% after 5h, then are placed in ultrasonic wave extraction instrument, surpass under 230W power
Sound extracts 60min, filtering, and filtrate is concentrated under reduced pressure under the conditions of 50 DEG C, medicinal extract drying, up to ginseng extract.
The preparation method of the Rhizoma Atractylodis Macrocephalae extract is：The Rhizoma Atractylodis Macrocephalae after crushing is added in the water of 8 times of weight, decocted 4 times,
Every time 1 it is small when, filtering, merging filtrate；The filtrate decompression of merging is condensed into the 3/4 of original volume, its weight is added in concentrate
1% citric acid, 1% protein sugar, 2% maltodextrin, spray drying, gained particle is Rhizoma Atractylodis Macrocephalae extract.
Claims (9)
1. the probiotics soft capsule containing natural extract, it is characterised in that soft capsule includes the component of following parts by weight：Ginseng
5~10 parts of extract, 1~5 part of Rhizoma Atractylodis Macrocephalae extract, 0.01~0.1 part of vitamin C, 5~15 parts of oligofructose, microcrystalline cellulose
3~8 parts, 1~10 part of Freeze-dry Powder of Probioctics, 10~30 parts of starch；
The Freeze-dry Powder of Probioctics contains the probiotics of following quantity：Bifidobacterium longum 4 × 108~6 × 108A/g, not tally bifid
Bacillus 5 × 106~1 × 107A/g, bifidobacterium adolescentis 2 × 105~5 × 105A/g, bifidobacterium breve 3 × 106~6 × 106
A/g, lactobacillus lactis number 1 × 105~5 × 105A/g, Gel Lactobacillus lactis number 1 × 107~3 × 107A/g, nisin number 2
×106~5 × 106A/g, lactobacillus bulgaricus 1 × 105~3 × 105A/g, Lactobacillus rhamnosus 1 × 105~3 × 105
A/g, hay bacillus 1 × 107~2.5 × 107A/g.
2. probiotics soft capsule according to claim 1, it is characterised in that the parts by weight of the component are：Ginseng extracts
5 parts of thing, 3 parts of Rhizoma Atractylodis Macrocephalae extract, 0.1 part of vitamin C, 5 parts of oligofructose, 6 parts of microcrystalline cellulose, 10 parts of Freeze-dry Powder of Probioctics,
10 parts of starch.
3. probiotics soft capsule according to claim 1, it is characterised in that the parts by weight of the component are：Ginseng extracts
8 parts of thing, 5 parts of Rhizoma Atractylodis Macrocephalae extract, 0.01 part of vitamin C, 10 parts of oligofructose, 8 parts of microcrystalline cellulose, Freeze-dry Powder of Probioctics 1
Part, 20 parts of starch.
4. probiotics soft capsule according to claim 1, it is characterised in that the parts by weight of the component are：Ginseng extracts
10 parts of thing, 1 part of Rhizoma Atractylodis Macrocephalae extract, 0.05 part of vitamin C, 15 parts of oligofructose, 3 parts of microcrystalline cellulose, Freeze-dry Powder of Probioctics 8
Part, 30 parts of starch.
5. probiotics soft capsule according to claim 1, it is characterised in that the Freeze-dry Powder of Probioctics contains following quantity
Probiotics：Bifidobacterium longum 4 × 108A/g, bifidobacterium bifidum 8 × 107A/g, bifidobacterium adolescentis 5 × 105A/g is short
Bifidobacterium 3 × 106A/g, lactobacillus lactis number 2.5 × 105A/g, Gel Lactobacillus lactis number 3 × 107A/g, nisin number 2
×106A/g, lactobacillus bulgaricus 2.5 × 105A/g, Lactobacillus rhamnosus 3 × 105A/g, hay bacillus 1 × 107。
6. probiotics soft capsule according to claim 1, it is characterised in that the Freeze-dry Powder of Probioctics contains following quantity
Probiotics：Bifidobacterium longum 5.3 × 108A/g, bifidobacterium bifidum 1 × 107A/g, bifidobacterium adolescentis 2 × 105A/g,
Bifidobacterium breve 4.8 × 106A/g, lactobacillus lactis number 5 × 105A/g, Gel Lactobacillus lactis number 1 × 107A/g, nisin
Number 3 × 106A/g, lactobacillus bulgaricus 3 × 105A/g, Lactobacillus rhamnosus 1 × 105A/g, hay bacillus 1.5 × 107
A/g.
7. probiotics soft capsule according to claim 1, it is characterised in that the Freeze-dry Powder of Probioctics contains following quantity
Probiotics：Bifidobacterium longum 6 × 108A/g, bifidobacterium bifidum 5 × 106A/g, bifidobacterium adolescentis 3.4 × 105A/g,
Bifidobacterium breve 6 × 106A/g, lactobacillus lactis number 1 × 105A/g, Gel Lactobacillus lactis number 1.8 × 107A/g, nisin
Number 5 × 106A/g, lactobacillus bulgaricus 1 × 105A/g, Lactobacillus rhamnosus 2.2 × 105A/g, hay bacillus 2.5 ×
107A/g.
8. according to probiotics soft capsule according to any one of claims 1 to 7, it is characterised in that the ginseng extract
Preparation method is：By ginseng under the conditions of -10~-40 DEG C, 12~24h is freeze-dried, 20~40 mesh is then crushed to, is immersed in
In the ethanol solution that volumetric concentration is 60%~95% after 5~10h, then it is placed in ultrasonic wave extraction instrument, in 220~240W power
40~60min of lower ultrasonic extraction, filtering, filtrate are concentrated under reduced pressure under the conditions of 50~60 DEG C, and medicinal extract drying, is extracted up to ginseng
Thing.
9. according to probiotics soft capsule according to any one of claims 1 to 7, it is characterised in that the Rhizoma Atractylodis Macrocephalae extract
Preparation method is：The Rhizoma Atractylodis Macrocephalae after crushing is added in the water of 5~10 times of weight, decocts 3~4 times, every time 1~3 it is small when, filtering,
Merging filtrate；The filtrate decompression of merging is condensed into the 3/4~1/2 of original volume, its weight 0.1%~1% is added in concentrate
Citric acid, 1%~1.5% protein sugar, 1.5%~2.5% maltodextrin, spray drying, gained particle is Rhizoma Atractylodis Macrocephalae
Extract.
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| CN201711211264.1A CN107927780A (en) | 2017-11-28 | 2017-11-28 | Probiotics soft capsule containing natural extract |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711211264.1A CN107927780A (en) | 2017-11-28 | 2017-11-28 | Probiotics soft capsule containing natural extract |
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Family
ID=61950141
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| CN201711211264.1A Pending CN107927780A (en) | 2017-11-28 | 2017-11-28 | Probiotics soft capsule containing natural extract |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113261673A (en) * | 2021-07-07 | 2021-08-17 | 然益科技(深圳)有限公司 | Health product with probiotics for strengthening nutrition and health effect of traditional Chinese medicine and preparation method thereof |
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