CN108938789A - A kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide - Google Patents

A kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide Download PDF

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CN108938789A
CN108938789A CN201810916424.0A CN201810916424A CN108938789A CN 108938789 A CN108938789 A CN 108938789A CN 201810916424 A CN201810916424 A CN 201810916424A CN 108938789 A CN108938789 A CN 108938789A
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parts
oligosaccharide
xylo
vitamin
combination formulations
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邵明星
郝君
李静
贲晓梅
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Anji Agus Biotech Co Ltd
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Anji Agus Biotech Co Ltd
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Abstract

The present invention relates to nutritional health food field more particularly to a kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide.It is made by the raw material of following parts by weight: 50 ~ 60 parts of xylo-oligosaccharide, 5 ~ 10 parts of vitamin, 2-6 parts of probiotics, 15-20 parts of Chinese herbal medicine extract, 2-6 parts of maltodextrin, 1-4 parts of allicin.The invention can be adjusted effectively and maintain intestine microenvironment.

Description

A kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide
Technical field
The present invention relates to nutritional health food field more particularly to a kind of adjusting intestinal microecology containing xylo-oligosaccharide are more Bacterium combination formulations.
Background technique
Xylo-oligosaccharide is also known as wood oligose, is the functional polymerization being combined by 2-7 xylose molecule with β-Isosorbide-5-Nitrae glycosidic bond Sugar.Xylo-oligosaccharide it is naturally occurring with bamboo root, water fruits and vegetables, cow's milk and honey in.The good physico-chemical property of xylo-oligosaccharide and physiology Effect, so that it is very prominent in functional oligose class product.It was most ground in Japan by Suntory company earlier than 1989 Function is made to introduce to the market, in Japan, xylo-oligosaccharide is considered as one of most promising functional oligose, has been obtained extensive Using.
Human body intestinal canal and body surface inhabit hundreds of millions of bacteriums, and type up to more than 400 weighs two kilograms, this works as In have and be pernicious to people, be known as harmful bacteria, have, referred to as probiotics beneficial to people, also have therebetween Conditioned pathogen, i.e., will lead to the sick bacterium of human body under certain condition, and the intracorporal probiotics of people mainly has lactic acid bacteria, bifid Bacillus etc..Scientific research confirms that probiotics can treat in the mass propagation of enteron aisle because largely using pseudo- caused by antibiotic Enteritis membranacea;Treat constipation and chronic diarrhea;Protect liver;It prevents and treats hypertension and artery sclerosis and anti-aging, reduce serum Cholesterol, pre- anti-cancer and the effect for inhibiting tumour growth.Xylo-oligosaccharide is that proliferation Bifidobacterium function is most strong in polymerization carbohydrate One of kind, its effect of property is nearly 20 times of other polymerization carbohydrates, do not have to hydrolyze the enzyme of xylo-oligosaccharide in human gastrointestinal tract, So it is preferably that Bifidobacterium is utilized that it, which can be directly entered big enteral, promotes Bifidobacterium proliferation while generating a variety of organic Acid.Enteron aisle pH value is reduced, inhibits harmful bacteria growth, is proliferated probiotics largely in enteron aisle, reaches above-mentioned health-care efficacy, this is just It is the health care secret place of xylo-oligosaccharide.Studies have shown that taking orally 0.7g daily, the ratio of large intestine Bifidobacterium is from 8.9% after two weeks Increase to 17.9%;Oral 1.4g daily, the ratio of large intestine Bifidobacterium increases to 33% from 9% after a week；Oral 3.5g daily, The ratio of large intestine Bifidobacterium increases to 21.7% from 3.7% after two weeks.As can be seen that xylo-oligosaccharide can be significant in above-mentioned data Be proliferated Bifidobacterium largely, thus reach make probiotics become enteron aisle dominant bacteria, exclude the purpose of harmful bacteria.
Summary of the invention
The invention solves the above problem, a kind of can effectively adjust and maintain intestinal microecology contains oligomeric wood is provided More bacterium combination formulations of sugar.
The technical solution that the present invention solves the problems, such as is to provide a kind of more bacterium connection of the adjusting intestinal microecology containing xylo-oligosaccharide Close preparation, it is characterised in that: be made by the raw material of following parts by weight: 50 ~ 60 parts of xylo-oligosaccharide, 5 ~ 10 parts of vitamin, prebiotic 2-6 parts of bacterium, 15-20 parts of Chinese herbal medicine extract, 2-6 parts of maltodextrin, 1-4 parts of allicin.
Preferably, it is made by the raw material of following parts by weight: 53 ~ 57 parts of xylo-oligosaccharide, 6 ~ 8 parts of vitamin, probiotics 3-5 Part, 16-18 parts of Chinese herbal medicine extract, 3-5 parts of maltodextrin, 2-3 parts of allicin.
Preferably, the vitamin be vitamin A, vitamin B, vitamin C, vitamin D, two kinds in vitamin E or It is a variety of.
Preferably, the probiotics is Lactobacillus rhamnosus, bifidobacterium lactis, lactobacillus reuteri, bifidobacterium longum, two Discrimination Bifidobacterium, lactobacillus plantarum, Lactobacillus casei, lactobacillus acidophilus, lactobacillus fermenti, three kinds in lactobacillus paracasei or It is a variety of.
Preferably, the viable bacteria amount of the probiotics is 109-1010CFU/g。
Preferably, the Chinese herbal medicine is one of pueraria lobata, dried orange peel, Radix Glycyrrhizae, Radix Paeoniae Alba, Poria cocos and Radix Codonopsis or a variety of.
Preferably, the Chinese herbal medicine extracting method: after mixing Chinese herbal medicine with distilled water with 1:40-1:60, it is placed in 80-90 DEG C heating extraction 8-12h, filters to take extracting solution, takes after extracting solution dehydrated alcohol alcohol precipitation and be deposited in 85-95 DEG C of crushed after being dried To 80-100 mesh.
Preferably, it is made of following methods: by xylo-oligosaccharide, vitamin, Chinese herbal medicine extract, maltodextrin, allicin It is uniformly mixed in parts by weight, distilled water is added and stirs to dissolution, obtains mixture；Probiotics is added to the mixture In, it is uniformly mixed and obtains the more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide.
Beneficial effects of the present invention:
1. the cooperation of xylo-oligosaccharide and allicin has significant restraining and sterilizing bacteria effect, it can significantly make Bifidobacterium, buttermilk Bacillus is largely proliferated, while strangling Escherichia coli, salmonella, staphylococcus aureus, shigella dysenteriae, typhoid bacillus, pneumonia Coccus, the harmful bacterias such as streptococcus exclude the purpose of harmful bacteria so that reaching makes probiotics become enteron aisle dominant bacteria.
2. by natural Chinese herbal medicine extract to protect stomach lining.
3. preparation of the invention is adjustable intestinal flora, promotes the growth of beneficial bacterium and inhibit the growth of harmful bacteria, can control More the intestines problem of repeatability recurrence, preparation method is simple and easy, and preparation cost is low, is suitble to large-scale industrial production.
Specific embodiment
It is a specific embodiment of the invention below, technical scheme of the present invention will be further described, but the present invention It is not limited to these examples.
Embodiment 1
After dried orange peel, Radix Glycyrrhizae mixture are mixed with distilled water with 1:40,80 DEG C of heating extraction 8h are placed in, extracting solution is filtered to take, mentions It takes to take after liquid dehydrated alcohol alcohol precipitation and is deposited in 85 DEG C of crushed after being dried to 80 mesh and obtains dried orange peel, licorice, saved in 4 DEG C It is spare.
According to mass parts by 50 parts of xylo-oligosaccharides, 2 parts of vitamin As, 3 parts of vitamin Bs, 15 parts of dried orange peels, licorice, 2 Part maltodextrin, 1 part of allicin and distilled water are mixed and stirred for uniformly, and it is double that 0.5 part of Lactobacillus rhamnosus, 1 part of cream is then added Discrimination bacillus, 0.5 part of lactobacillus reuteri are uniformly mixed, and the more bacterium joint systems of the adjusting intestinal microecology containing xylo-oligosaccharide are made Agent.
Embodiment 2
After Radix Paeoniae Alba is mixed with distilled water with 1:50,82 DEG C of heating extraction 10h are placed in, filter to take extracting solution, extracting solution is with anhydrous It is taken after ethyl alcohol alcohol precipitation and is deposited in 90 DEG C of crushed after being dried to 90 mesh and obtains radix paeoniae alba extraction, saved backup in 4 DEG C.
According to mass parts by 55 parts of xylo-oligosaccharides, 2 parts of vitamin As, 2 parts of vitamin Es, 2 parts of vitamin Cs, 1 part of vitamin D, 17 parts of radix paeoniae alba extractions, 4 portions of maltodextrins, 2 parts of allicins and distilled water are mixed and stirred for uniformly, and 0.5 part of sandlwood is then added Sugared lactobacillus, 1 part of bifidobacterium lactis, 1.5 parts of lactobacillus reuteris, 1 part of lactobacillus plantarum are uniformly mixed, and are made and are contained oligomeric wood The more bacterium combination formulations of adjusting intestinal microecology of sugar.
Embodiment 3
After Radix Codonopsis is mixed with distilled water with 1:60,90 DEG C of heating extraction 12h are placed in, filter to take extracting solution, extracting solution is with anhydrous It is taken after ethyl alcohol alcohol precipitation and is deposited in 95 DEG C of crushed after being dried to 100 mesh and obtains Radix Codonopsis extract, saved backup in 4 DEG C.
According to mass parts by 60 parts of xylo-oligosaccharides, 2 parts of vitamin As, 1 part of vitamin B, 2 parts of vitamin Es, 3 parts of vitamin Cs, Uniformly, then 2 parts of vitamin Ds, 20 Fen Bai Radix Codonopsis extracts, 6 portions of maltodextrins, 4 parts of allicins and distilled water are mixed and stirred for 2 parts of lactobacillus fermentis, 1 part of bifidobacterium lactis, 1.5 parts of lactobacillus reuteris, 1 part of lactobacillus plantarum, 0.5 part of cheese cream bar is added Bacterium is uniformly mixed, and the more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide are made.
Function test
Animal subject: weight is kind female mice 50, the SPF grade Kunming of 20 ± 2g.Every 10 are divided into one group, and totally 5 groups.Every group Respectively correspond blank group, embodiment 1, embodiment 2, embodiment 3 preparation tested.
Dosage and usage: giving animal subject, daily stomach-filling 1 time in a manner of stomach-filling, and stomach-filling volume is 0.2ml/10g .bw, equal amount of distilled water, continuous gavage 14d are given in blank control group filling.
Test method: the counting of intestinal flora: giving before tested material and last time to after test medicine for 24 hours, it is sterile to adopt Take stool in mice, be put into the sterilized test tube equipped with 3ml dilution, after weighing concussion shake up, keep excrement perfectly homogenous in In dilution.10 times are taken to be serially diluted to 10-8.Select suitable dilution be seeded on each culture medium respectively cultivate it is prebiotic Bacterium.After cultivating 48~72h, with colonial morphology, gram stain microscopy counts bacterium colony, calculate every gram it is wet just in each probiotics bacterial Number is fallen, carries out statistical disposition after removing logarithm.
Test result is shown in Table 1, can be seen that after continuously to intragastric administration on mice 14d from data in table, prebiotic in mouse intestinal Bacterium number amount is changed.Compared to blank group, the viable count of embodiment 1, embodiment 2 and embodiment 3 significantly increases, and illustrates this The solid beverage of invention can effectively facilitate proliferation of probiotics in enteron aisle, adjust intestinal flora.
Table 1
Specific embodiment described herein is only an example for the spirit of the invention.The technical field of the invention Technical staff can make various modifications or additions to the described embodiments or be substituted in a similar manner, but Without departing from the spirit of the invention or going beyond the scope defined by the appended claims.

Claims (8)

1. a kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide, it is characterised in that: press following parts by weight Raw material be made: 50 ~ 60 parts of xylo-oligosaccharide, 5 ~ 10 parts of vitamin, 2-6 parts of probiotics, 15-20 parts of Chinese herbal medicine extract, malt 2-6 parts of dextrin, 1-4 parts of allicin.
2. a kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide according to claim 1, feature It is: is made by the raw material of following parts by weight: 53 ~ 57 parts of xylo-oligosaccharide, 6 ~ 8 parts of vitamin, 3-5 parts of probiotics, Chinese herbal medicine 16-18 parts of extract, 3-5 parts of maltodextrin, 2-3 parts of allicin.
3. a kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide according to claim 1, feature Be: the vitamin is vitamin A, vitamin B, vitamin C, vitamin D, two or more in vitamin E.
4. a kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide according to claim 1, feature Be: the probiotics is Lactobacillus rhamnosus, bifidobacterium lactis, lactobacillus reuteri, bifidobacterium longum, not tally bifid bar Bacterium, lactobacillus plantarum, Lactobacillus casei, lactobacillus acidophilus, lactobacillus fermenti, three kinds or a variety of in lactobacillus paracasei.
5. a kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide according to claim 1, feature Be: the viable bacteria amount of the probiotics is 109-1010CFU/g。
6. a kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide according to claim 1, feature Be: the Chinese herbal medicine is one of pueraria lobata, dried orange peel, Radix Glycyrrhizae, Radix Paeoniae Alba, Poria cocos and Radix Codonopsis or a variety of.
7. a kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide according to claim 1, feature It is: the Chinese herbal medicine extracting method: after mixing Chinese herbal medicine with distilled water with 1:40-1:60, is placed in 80-90 DEG C of heating extraction 8-12h filters to take extracting solution, takes after extracting solution dehydrated alcohol alcohol precipitation and be deposited in 85-95 DEG C of crushed after being dried to 80-100 mesh.
8. a kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide according to claim 1, feature It is: is made of following methods: in parts by weight by xylo-oligosaccharide, vitamin, Chinese herbal medicine extract, maltodextrin, allicin It is uniformly mixed, distilled water is added and stirs to dissolution, obtains mixture；Probiotics is added in the mixture, is uniformly mixed Obtain the more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide.
CN201810916424.0A 2018-08-13 2018-08-13 A kind of more bacterium combination formulations of the adjusting intestinal microecology containing xylo-oligosaccharide Pending CN108938789A (en)

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CN109385387A (en) * 2018-12-28 2019-02-26 上海源耀生物股份有限公司 The lactobacillus reuteri of anti-TGEV a kind of and its application
CN109984316A (en) * 2019-04-01 2019-07-09 安吉艾格赛思生物科技有限公司 A kind of adjusting intestinal microenvironment biological products containing xylo-oligosaccharide
CN114190548A (en) * 2021-11-24 2022-03-18 重庆万源佳药业有限公司 Microecological extract with arteriosclerosis intervention function and preparation method thereof

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CN104415027A (en) * 2013-08-30 2015-03-18 深圳华大基因科技有限公司 Application of allicin in adjusting animal intestinal flora
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CN104415027A (en) * 2013-08-30 2015-03-18 深圳华大基因科技有限公司 Application of allicin in adjusting animal intestinal flora
CN107874251A (en) * 2017-11-14 2018-04-06 广东健来福云健康科技股份有限公司 A kind of eight delicacies probiotic composition with strengthening the spleen and stomach benefit function of intestinal canal

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CN109385387A (en) * 2018-12-28 2019-02-26 上海源耀生物股份有限公司 The lactobacillus reuteri of anti-TGEV a kind of and its application
CN109984316A (en) * 2019-04-01 2019-07-09 安吉艾格赛思生物科技有限公司 A kind of adjusting intestinal microenvironment biological products containing xylo-oligosaccharide
CN114190548A (en) * 2021-11-24 2022-03-18 重庆万源佳药业有限公司 Microecological extract with arteriosclerosis intervention function and preparation method thereof

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