CN103918793A - Stomach-invigorating and digestion-helping probiotics goat milk tablet and preparation method thereof - Google Patents
Stomach-invigorating and digestion-helping probiotics goat milk tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a stomach-invigorating and digestion-helping probiotics goat milk tablet and a preparation method thereof. The stomach-invigorating and digestion-helping probiotics goat milk tablet comprises following components in percentage by mass: 53.5%-80.2% of goat milk powder, 10%-30% of a mixture A, 0.1%-1% of freeze-drying probiotics powder, 5%-7% of sucrose, 0.5%-1.0% of synanthrin, 4%-7% of glucose and 0.2%-0.5% of microcrystalline cellulose; the mixture A is obtained by mixing white atractylodes rhizome, mangnolia officinalis, codonopsis pilosula and crataegus pinnatifida bunge in a mass ratio of 1 to 1 to 2 to 2. According to the stomach-invigorating and digestion-helping probiotics goat milk tablet, the white atractylodes rhizome, the mangnolia officinalis, the codonopsis pilosula and the crataegus pinnatifida bunge are added into goat milk and the edible and pharmaceutical substances and the probiotics are pressed into the tablet, so that the stomach-invigorating and digestion-helping probiotics goat milk tablet has the stomach-invigorating and digestion-helping effects of all components and can also effectively improve the intestinal tract nutrition and flora balance. The goat milk contains EGF (Epidermal Growth Factor) so that the growth of epithelial cells is promoted; the tablet also has a repairing effect on the epithelial cells of mucosae including intestines and stomaches, tracheas, skins and the like; the stomach-invigorating and digestion-helping probiotics goat milk tablet has abundant nutrition and is convenient to carry and eat.
Description
Technical field
The invention belongs to field of health care food, relate to a kind of stomach strengthening and digestion promoting probio goat milk sheet and preparation method thereof.
Background technology
Goat milk, with high nutrition, high-quality health idea, strides greatly and has come into consumer's sight line, has met national consumption hobby and nutritional need, becomes the another high consumption focus outside milk.Especially the high-quality goat milk that Shaanxi produces, be subject to especially the height approval of domestic market, and more and more goat milk brand starts to go abroad, and explores overseas market actively, fully demonstrates the potentiality that should not be underestimated in goat milk market.
Goat Milk has been widely regarded as and has been particularly suitable for the food that the elderly, sick people, sick convalescent people and infant use.Goat milk is existing has many advantages for milk: 1. Goat Milk medium chain fatty acid content is high, and wherein aliphatic acid is divided into three kinds, long, medium and short chain.Medium chain and SCFA are more easily subject to the attack of body fat enzyme and digested absorption than long-chain.In addition, medium chain fatty acid has unique mechanism of absorption, can at small intestine, directly be absorbed without the digestion of pancreas enzyme and cholate, and the content of Goat Milk medium chain fatty acid is the twice of milk.2. Goat Milk fat globule diameter is little.The diameter of fat globule is less, just has larger surface area to attack for human intestine's lipase, makes fat be decomposed faster.In general, the digestion of Goat Milk is than milk fast 20%.Although milk and the Goat Milk separately diameter of fat globule have difference,, on average, the diameter of Goat Milk fat globule is more much smaller than milk.General upper, the diameter of Goat Milk fat globule is 2-2.5 micron, and milk is 3-4.25 micron.The digestion process of little, the frangible protein of curdled milk hardness that Goat Milk forms in human body is first under hydrochloric acid in gastric juice effect, to form curdled milk, and the digestion that is then decomposed, for amino acid, is absorbed at small intestine afterwards.The soft durometer of ziega directly affects the digested speed of protein and efficiency.In Goat Milk, main protein is beta-casein, has structural difference with protein alpha-S1 casein main in milk.It is soft more frangible than milk that the ziega that Goat Milk beta-casein forms has under one's belt been proved to be.3. strengthen the absorption of iron and calcium.Iron in milk and calcium, owing to there being interaction, can have influence on wherein a kind of absorption of element.And iron and calcium in Goat Milk does not have this interaction, so bioavilability is higher than milk.
Probio (Probiotics), claim again probiotic, regulator, raw rhzomorph, viable bacteria element etc., refer to certain microorganism formulation or fermented product, by regulating host's mucous membrane and systemic immune function and improving enteral nutrition and colony balance, host is produced to useful physiological action, by colonized action, change the composition of a certain position of host flora, thereby produce, be conducive to the single of host health effect or form clear and definite mixed microorganism.Up to now, the probio that scientist has found can be divided into three major types substantially, comprising: 1. lactobacillus class (as lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, lactobacillus plantarum etc.); 2. Bifidobacterium class (as bifidobacterium longum, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis etc.); 3. gram-positive cocci (as streptococcus fecalis, galactococcus, intermediary streptococcus etc.).Probio is as a frontier, and in recent years, the special physiological activity of probio is widely used in food, except being applied to fermented dairy product, is also just progressively applied to developing various functional foods.At present, probio is mainly used in the fields such as food, functional food, dietary supplements, medicinal organism goods and feed.Being referred to as probiotic food containing the food of profitable probliotics, mainly comprise the food of direct interpolation probio and through the food of probiotics fermention.Probio the most general application in field of food is still dairy products field, comprises acidified milk, active lactic acid bacteria drink, cheese, sour cream, kefyr, fruit juice, cereal preparation, biscuit etc.With probio bacterial classification have Bifidobacterium (Bifidobateria), Bacillus acidi lactici and some streptococcus, wherein, Bacillus acidi lactici is conventional lactobacillus acidophilus (Lactobicullus acidophilus), Lactobacillus casei (L.casei), lactobacillus bulgaricus (L.bulgaricus) etc.The probio bacterial classification that can be used for health food of China Ministry of Public Health approval at present has: lactobacillus acidophilus, Lactobacillus casei, lactobacillus reuteri, Lactobacillus rhamnosus, bifidobacterium bifidum, bifidobacterium infantis, bifidobacterium breve, bifidobacterium longum, blue and green Bifidobacterium, lactobacillus bulgaricus, streptococcus thermophilus etc.
Radix Codonopsis another name Shangdang ginseng, yellow ginseng, platform Radix Codonopsis, upper Radix Codonopsis.Be born in the bushes of mountain region and border.Main product in Shanxi, province and the various places, northeast such as Shaanxi, Gansu, Sichuan.Radix Codonopsis is perennial herb, root elongated cylindrical, and there is the root head expanding on top, and crust milk yellow, to light taupe brown, has wrinkle in length and breadth.Radix Codonopsis mainly contains compound and some other micro constitutents such as polysaccharide, alcohol glycoside, Phenylpropanoid Glycosides glycoside, alkaloid, has higher medicine-food two-purpose to be worth.Radix Codonopsis can be corrected the gastrointestinal motility dysfunction of pathological state, the neutral extract of n-butanol with Radix Codonopsis has preventive and therapeutic action to stress ulcer, have tonifying middle-Jiao and Qi, the effect of invigorating the spleen benefit lung has wide practical use in food, medical industry simultaneously.
Hawthorn has another name called large-fruited Chinese hawthorn, is the ripening fruits of rose family machaka or dungarunga fructus crataegi cuneatae or hawthorn.Stone fruit, caryoplasm is hard, and pulp is thin, and taste is micro-sour and astringent.In Heilungkiang, the ground such as Jilin, Liaoning, the Inner Mongol, oral hawthorn can promote the secretion of enzyme in stomach, promotes digestion, contained lipase also can help liposuction and digestion, fruit is raw-eaten or make jam fruitcake; After drying, being used as medicine, having that stomach invigorating, long-pendingization that disappear are stagnant, the effect of the loose stasis of blood of having a respite, is Chinese distinctive medicine fruit dual-purpose seeds.Time of the year when autumn changes into winter gathers during fruit maturation.Dry raw using or stir-fry use.
The bighead atractylodes rhizome is called in art, and winter art, in the latent bighead atractylodes rhizome, is the rhizome of the feverfew bighead atractylodes rhizome.Main product in Zhejiang, the province such as Anhui, Hubei, Hunan, Jiangxi.The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.Effect: strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Can be used for insufficiency of the spleen food few, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.
The purple Piao of bark of official magnolia another name, purple oil Piao, Wen Piao etc. are dry dry hide, Gen Pi and the branch skin of Magnoliaceae, the magnolia bark of official magnolia or Magnolia bilola.This medicinal material is warm in nature, bitter, fortunately.The diseases such as stagnation of QI due to dyspepsia, abdominal distention constipation, damp retention in middle-jiao are had to therapeutic action, there is eliminating dampness loose full, the loose ruffian that helps digestion, the effect of depressing Qi and relieving asthma simultaneously.
Microcrystalline cellulose is the cellulose of a kind of purifying, part depolymerization, white, odorless, tasteless, the crystalline powder being comprised of small porous particle.Be widely used in the industries such as pharmacy, cosmetics, food, not only can be used for wet granulation and also can be used for dry method direct tablet compressing.In tablet preparation, can be used as disintegrant and adhesive, these two kinds of effects are integrated, effectively avoided multiple additives to use the harmful effect causing simultaneously.
In recent years, the research great majority of hawthorn and Radix Codonopsis are for health protection tea, drinks etc., patent (CN103494135A) has been announced the preparation method of sweet tea haw flakes, patent (CN103504054A) has been announced the preparation method that Radix Codonopsis protects heart tea, and patent (CN103509685A) has been announced the preparation method that Radix Codonopsis protects heart wine; Aspect medical, slightly report, patent (CN102793896A) has been announced a kind of preparation method of Radix Astragali Radix Codonopsis sheet, to specially controlling a series products of alpastic anemia.But for the bark of official magnolia with the bighead atractylodes rhizome except relevant report aspect health protection tea is a lot of, be applied to slightly relate in pharmaceuticals industry and tablet, patent (CN103536666A) has been announced a kind of bighead atractylodes rhizome Chinese medicine preparation, and patent (CN102847046A) has been announced the preparation method of one group of real spleen sheet of the bark of official magnolia bighead atractylodes rhizome.But the report being applied in tablet the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn as the prebiotic factor is very few, and application microcrystalline cellulose is also less as adhesive and this double-deck role's of disintegrant relevant report, goat milk is compared with milk and has many advantages simultaneously.Therefore in goat milk sheet, added probio and can effectively improve enteral nutrition and colony balance with the material that is beneficial to stomach strengthening and digestion promoting, promoted the absorption of food digestion and nutriment, made human body become more healthy and dynamic.
Summary of the invention
For above-mentioned defect or deficiency, the object of the present invention is to provide a kind of stomach strengthening and digestion promoting probio goat milk sheet and preparation method thereof.
For reaching above object, technical scheme of the present invention is:
A kind of stomach strengthening and digestion promoting probio goat milk sheet, the goat milk powder that comprises by mass percentage 53.5%-80.2%, the mixture A of 10%-30%, freeze-drying probiotics bacterial powder, the sucrose of 5%-7%, the glucose of the synanthrin of 0.5%-1.0%, 4%-7% and the microcrystalline cellulose of 0.2%-0.5% of 0.1%-1%;
Described mixture A is mixed to get by the mass ratio of 1:1:2:2 by the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn.
Described freeze-drying probiotics bacterial powder is the mixture of probio and compound freeze drying protectant;
Wherein probio mixes with the ratio of the compound freeze drying protectant of 1mL according to every g probio with compound freeze drying protectant;
Wherein probio employing viable count is (1.0-3.0) * 10
11lactobacillus acidophilus bacterium powder, viable count be (1.0-3.0) * 10
11the Mixed Microbes of these two kinds of arbitrary proportions of bifidobacterium bifidum bacterium powder;
Compound freeze drying protectant comprises by mass percentage and comprising: the skimmed milk power of 18%-50%, the trehalose of 8%-20%, the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% phosphate buffer.
A preparation method for stomach strengthening and digestion promoting probio goat milk sheet, comprises the following steps:
1) will after the clean peeling of fresh hawthorn, be dried to constant weight;
2) be ground into after the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are mixed by the mass ratio of 1:1:2:2 Powderedly, then cross 40-80 object sieve and obtain mixture A;
3) probio of getting after activation is accessed the fermentation tank culture 18h of 10L MRS culture medium with 2～5% inoculum concentration, in incubation, every 3-4h, stir once, turn/min of rotating speed 60, mixing time 2min, then, with centrifuge, with the centrifugal 12min of rotating speed of 10000 turn/min, make probiotics bacterial mud, then in probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL, utilize vortex mixed instrument to be mixed even, at-40～-20 ℃ of pre-freeze 12～24h, then move to freeze drier freeze drying 24h acquisition freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant comprises: by mass percentage by the skimmed milk power of 18%-50%, the sodium hydrogen phosphate of the trehalose of 8%-20%, 1%-2%, the phosphate buffer of the lactose of 1%-10% and 40%-50% form;
4) by sheep breast through purify and standardization after, reduced pressure concentration makes solid content reach 42%～50% and obtains raw material sheep breast, by crossing 40～80 mesh sieves after spray dry and cool to room temperature, obtains goat milk powder;
5) by mass percentage by the goat milk powder of 53.5%-80.2%, the mixture A of 10%-30%, 0.1%-1% freeze-drying probiotics bacterial powder, the sucrose of 5%-7%, the synanthrin of synanthrin 0.5%-1.0%,, the microcrystalline cellulose of the glucose of 4%-7% and 0.2%-0.5% mixes, obtain mixture B;
Then utilize tablet press machine, the mixture B unit of making viable count is reached to (1.0-3.0) * 10
7～(1.0-3.0) * 10
9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn compound probiotic of cfu/g.
The dry employing blast drier of described step 1) is dry at 70 ℃.
Described step 2) pulverize employing and meet operative norm Q/12NK4558-2006, power of motor is 1200W, and the medicinal herb grinder that rotating speed is 2400r/min is pulverized.
Described probio is that viable count is 1.0-3.0 * 10
11lactobacillus acidophilus bacterium powder, viable count be 1.0-3.0 * 10
11the mixing of these two kinds of arbitrary proportions of bifidobacterium bifidum bacterium powder.
The activation process of described probio is as follows:
Lactobacillus acidophilus is adopted under 37 ℃ of condition of culture to MRS fluid nutrient medium activation three times, the cysteine hydrochloride that Bifidobacterium is added culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture, with 2～5% inoculum concentration, transfer at every turn, wherein all under 37 ℃ of condition of culture, cultivate 20-24h first twice, under 37 ℃ of condition of culture, cultivate 18h for the third time, then carry out microscopy, survey OD value, determine without activating for the third time and obtain activating probio after miscellaneous bacteria.
The dry EAT of described spraying is 160～165 ℃, and temperature of outgoing air is 75～65 ℃.
It is 5～20 turn/min that the mixing of described step 5) adopts rotating speed, the three-dimensional motion mixer that power of motor is 0.5Kw;
The maximum compressing tablet pressure of described single-punching tablet press: 50KN; Compressing tablet diameter:
sheet is heavily 1.0～1.6g; Hardness is at 4～7N.
Compared with the prior art, beneficial effect of the present invention is:
1) in the present invention, main component is goat milk powder, because Goat Milk is rich in high-quality protein and aliphatic acid and the several mineral materials such as albumin that health is played an important role, globulin, to nutrient absorption, bad syndrome patient has good health care and therapeutic action.Goat milk fat globule little (be only milk 1/3), and be rich in be beneficial to that body directly utilizes in, short chain unrighted acid, absorptivity is very high.The EGF(EGF containing in goat milk), when promoting epithelial cell growth, the mucomembranous epithelial cells such as stomach, tracheae and skin are had to repair, can urge digestion again can tranquilizing and allaying excitement (because containing cyclic nucleotide), and can strengthen immunity of organisms, and regulate human body nutrient balance, improve sleep quality, the comfort cushioning characteristic of its meta-alkalescence also has the effect that promotes rehabilitation to diseases such as ephritis, tuberculosis and asthma, be infant, pregnant woman, old man and patient's excellent health products.
2) added in the present invention probio, probio has obvious facilitation to health, science proves that it has following effect: 1, prevent and improve constipation, diarrhoea, safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, pass through bidirectional modulation, prevent constipation, diarrhoea, adjusts function of intestinal canal disorderly, prevents various intestines problems.2, antitumor, from the isolated antitumor polysaccharide of Bifidobacterium, enzyme is lost activity, thus the generation of pre-anti-cancer.3, control the cholesterol in serum, a large amount of clinical trial both at home and abroad confirm, take lactobacillary milk goods and have the human serum of minimizing cholesterol level, reduce the effect of cardiovascular disease incidence rate.1997, Gimland has proposed lactic acid bacteria at first can promote by degraded cholate the catabolism of cholesterol, thereby reduced the viewpoint of cholesterol level.4, biological barrier effect, reduces the generation of harmful substance in harmful bacteria metabolin, forms the biomembrane barrier that one deck has protective effect, stops the invasion of pernicious bacteria, accelerates the discharge of various toxin in enteron aisle.Play the effect that improves intestinal environment and protection enteron aisle.5, promote generation and the absorption of nutriment in enteron aisle, synthetic vitamin B can self be synthesized or promote to Bifidobacterium
1, B
2, B
6, B
12and the nutriment of the needed by human such as amino acid., improve the absorption to calcium ion, realize stomach normalization.6, row's stool, the fat that purifies the blood, hypotensive, accelerate lipolysis, old loose fat in adsorbent, reduces serum cholesterol level.Thereby hypertension and artery sclerosis are had to certain prevention effect.7, improve immunity, there is the cytotostatic of promotion and increase intestine immunity enhanced feature, prevent antibiotic side effect, trigger cell mutation factor is had to resistant function.Anti-ageing, promote longevity.8, improve lactose intolerance, the ferment that Bifidobacterium reduces lactose, to help improve lactose intolerance.9, other functions, as food hypersenstivity, prevention diabetes etc.Exactly because probio, for the effect of human health, receives much concern it.
3) add in the present invention Radix Codonopsis, mainly contained compound and some other micro constitutents such as polysaccharide, alcohol glycoside, Phenylpropanoid Glycosides glycoside, alkaloid, had higher medicine-food two-purpose to be worth.Radix Codonopsis can be corrected the gastrointestinal motility dysfunction of pathological state, the neutral extract of n-butanol with Radix Codonopsis has preventive and therapeutic action to stress ulcer, have tonifying middle-Jiao and Qi, the effect of invigorating the spleen benefit lung has wide practical use in food, medical industry simultaneously.
4) added in the present invention hawthorn, can promote the secretion of enzyme in stomach, promoted digestion, contained lipase also can help liposuction and digestion, and fruit is raw-eaten or make jam fruitcake; After drying, being used as medicine, having that stomach invigorating, long-pendingization that disappear are stagnant, the effect of the loose stasis of blood of having a respite, is Chinese distinctive medicine fruit dual-purpose seeds.
5) add in the present invention the bighead atractylodes rhizome, there is multinomial medicinal efficacy: strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive, also can be used for insufficiency of the spleen food few, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.
6) added in the present invention the bark of official magnolia, this medicinal material is warm in nature, bitter, fortunately.The diseases such as stagnation of QI due to dyspepsia, abdominal distention constipation, damp retention in middle-jiao are had to therapeutic action, there is eliminating dampness loose full, the loose ruffian that helps digestion, the effect of depressing Qi and relieving asthma simultaneously.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in further detail, and the explanation of the invention is not limited.
Embodiment 1:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; After fresh hawthorn is cleaned to peeling, be cut into small pieces, then adopt respectively blast drier to be dried to constant weight at 70 ℃;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are mixed to rear employing by the mass ratio of 1:1:2:2 and meet operative norm Q/12NK4558-2006, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 40 object sieves and obtain mixture A;
3) first, probio is adopted under 37 ℃ of condition of culture the activation of MRS fluid nutrient medium obtain activating probio three times, the probio of getting after activation is accessed the fermentation tank culture 18h of 10L MRS culture medium with 2% inoculum concentration, in incubation, every 3h, stir once, turn/min of rotating speed 60, mixing time 2min, then, with centrifuge, with the centrifugal 12min of rotating speed of 10000 turn/min, make probiotics bacterial mud, then in probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL, utilize vortex mixed instrument to be mixed even, at-40 ℃ of pre-freeze 12h, move to again freeze drier freeze drying 24h and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant is by mass percentage by 18% skimmed milk power, 20% trehalose, and 2% sodium hydrogen phosphate, 10% lactose and 50% phosphate buffer form;
Wherein, the activation process of probio specifically comprises:
Lactobacillus acidophilus is adopted under 37 ℃ of condition of culture to MRS fluid nutrient medium activation three times, the cysteine hydrochloride that Bifidobacterium is added culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture, with 5% inoculum concentration, transfer at every turn, wherein all under 37 ℃ of condition of culture, cultivate 20-24h first twice, under 37 ℃ of condition of culture, cultivate 18h for the third time, then carry out microscopy, survey OD value, determine without activating for the third time and obtain activating probio after miscellaneous bacteria.
4) make solid content reach 42% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, after raw material sheep breast is dried (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) by spraying, cool to room temperature is crossed the sub goat milk powder that obtains of 40 mesh sieves;
5) by mass percentage by 53.5% goat milk powder, 30% mixture A, it is 5 turn/min that 1% freeze-drying probiotics bacterial powder, 7% sucrose, 1.0% synanthrin, 7% glucose and 0.5% microcrystalline cellulose adopt rotating speed, and the three-dimensional motion mixer that power of motor is 0.5Kw mixes;
Then utilize single-punching tablet press, the unit's of making viable count reaches (1.0-3.0) * 10
7～(1.0-3.0) * 10
9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum compressing tablet pressure of described tablet press machine: 50KN; Compressing tablet diameter:
sheet is heavily 1.0g; Hardness is at 4～7N.
Embodiment 2:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; After fresh hawthorn is cleaned to peeling, be cut into small pieces, then adopt respectively blast drier to be dried to constant weight at 70 ℃;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are mixed to rear employing by the mass ratio of 1:1:2:2 and meet operative norm Q/12NK4558-2006, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 60 object sieves and obtain mixture A;
3) first, probio is adopted under 37 ℃ of condition of culture the activation of MRS fluid nutrient medium obtain activating probio three times, the probio of getting after activation is accessed the fermentation tank culture 18h of 10L MRS culture medium with 3% inoculum concentration, in incubation, every 4h, stir once, turn/min of rotating speed 60, mixing time 2min, then, with centrifuge, with the centrifugal 12min of rotating speed of 10000 turn/min, make probiotics bacterial mud, then in probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL, utilize vortex mixed instrument to be mixed even, at-30 ℃ of pre-freeze 18h, move to again freeze drier freeze drying 24h and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant is by mass percentage by 50% skimmed milk power, 8% trehalose, and 1% sodium hydrogen phosphate, 1% lactose and 40% phosphate buffer form;
Wherein, the activation process of probio specifically comprises:
Lactobacillus acidophilus is adopted under 37 ℃ of condition of culture to MRS fluid nutrient medium activation three times, the cysteine hydrochloride that Bifidobacterium is added culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture, with 5% inoculum concentration, transfer at every turn, wherein all under 37 ℃ of condition of culture, cultivate 20-24h first twice, under 37 ℃ of condition of culture, cultivate 18h for the third time, then carry out microscopy, survey OD value, determine without activating for the third time and obtain activating probio after miscellaneous bacteria.
4) make solid content reach 45% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, after raw material sheep breast is dried (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) by spraying, cool to room temperature is crossed the sub goat milk powder that obtains of 60 mesh sieves;
5) by mass percentage by 80.2% goat milk powder, 10% mixture A, it is 8 turn/min that 0.1% freeze-drying probiotics bacterial powder, 5% sucrose, 0.5% synanthrin, 4% glucose and 0.2% microcrystalline cellulose adopt rotating speed, and the three-dimensional motion mixer that power of motor is 0.5Kw mixes;
Then utilize single-punching tablet press, the unit's of making viable count reaches (1.0-3.0) * 10
7～(1.0-3.0) * 10
9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum compressing tablet pressure of described tablet press machine: 15KN; Compressing tablet diameter:
sheet is heavily 1.4g; Hardness is at 4～7N.
Embodiment 3:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; After fresh hawthorn is cleaned to peeling, be cut into small pieces, then adopt respectively blast drier to be dried to constant weight at 70 ℃;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are mixed to rear employing by the mass ratio of 1:1:2:2 and meet operative norm Q/12NK4558-2006, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 80 object sieves and obtain mixture A;
3) first, probio is adopted under 37 ℃ of condition of culture the activation of MRS fluid nutrient medium obtain activating probio three times, the probio of getting after activation is accessed the fermentation tank culture 18h of 10L MRS culture medium with 4% inoculum concentration, in incubation, every 3h, stir once, turn/min of rotating speed 60, mixing time 2min, then, with centrifuge, with the centrifugal 12min of rotating speed of 10000 turn/min, make probiotics bacterial mud, then in probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL, utilize vortex mixed instrument to be mixed even, at-40 ℃ of pre-freeze 12h, move to again freeze drier freeze drying 24h and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant is by mass percentage by 18% skimmed milk power, 20% trehalose, and 2% sodium hydrogen phosphate, 10% lactose and 50% phosphate buffer form;
Wherein, the activation process of probio specifically comprises:
Lactobacillus acidophilus is adopted under 37 ℃ of condition of culture to MRS fluid nutrient medium activation three times, the cysteine hydrochloride that Bifidobacterium is added culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture, with 5% inoculum concentration, transfer at every turn, wherein all under 37 ℃ of condition of culture, cultivate 20-24h first twice, under 37 ℃ of condition of culture, cultivate 18h for the third time, then carry out microscopy, survey OD value, determine without activating for the third time and obtain activating probio after miscellaneous bacteria.
4) make solid content reach 42% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, after raw material sheep breast is dried (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) by spraying, cool to room temperature is crossed the sub goat milk powder that obtains of 80 mesh sieves;
5) by mass percentage by 60% goat milk powder, 25% mixture A, it is 5 turn/min that 0.5% freeze-drying probiotics bacterial powder, 6% sucrose, 1.0% synanthrin, 7% glucose and 0.5% microcrystalline cellulose adopt rotating speed, and the three-dimensional motion mixer that power of motor is 0.5Kw mixes;
Then utilize single-punching tablet press, the unit's of making viable count reaches (1.0-3.0) * 10
7～(1.0-3.0) * 10
9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum compressing tablet pressure of described tablet press machine: 50KN; Compressing tablet diameter:
sheet is heavily 1.5g; Hardness is at 4～7N.
Embodiment 4:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; After fresh hawthorn is cleaned to peeling, be cut into small pieces, then adopt respectively blast drier to be dried to constant weight at 70 ℃;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are mixed to rear employing by the mass ratio of 1:1:2:2 and meet operative norm Q/12NK4558-2006, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 50 object sieves and obtain mixture A;
3) first, probio is adopted under 37 ℃ of condition of culture the activation of MRS fluid nutrient medium obtain activating probio three times, the probio of getting after activation is accessed the fermentation tank culture 18h of 10L MRS culture medium with 5% inoculum concentration, in incubation, every 4h, stir once, turn/min of rotating speed 60, mixing time 2min, then, with centrifuge, with the centrifugal 12min of rotating speed of 10000 turn/min, make probiotics bacterial mud, then in probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL, utilize vortex mixed instrument to be mixed even, at-30 ℃ of pre-freeze 18h, move to again freeze drier freeze drying 24h and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant is by mass percentage by 50% skimmed milk power, 8% trehalose, and 1% sodium hydrogen phosphate, 1% lactose and 40% phosphate buffer form;
Wherein, the activation process of probio specifically comprises:
Lactobacillus acidophilus is adopted under 37 ℃ of condition of culture to MRS fluid nutrient medium activation three times, the cysteine hydrochloride that Bifidobacterium is added culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture, with 5% inoculum concentration, transfer at every turn, wherein all under 37 ℃ of condition of culture, cultivate 20-24h first twice, under 37 ℃ of condition of culture, cultivate 18h for the third time, then carry out microscopy, survey OD value, determine without activating for the third time and obtain activating probio after miscellaneous bacteria.
4) make solid content reach 45% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, after raw material sheep breast is dried (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) by spraying, cool to room temperature is crossed the sub goat milk powder that obtains of 60 mesh sieves;
5) by mass percentage by 70% goat milk powder, 20% mixture A, it is 8 turn/min that 0.3% freeze-drying probiotics bacterial powder, 5% sucrose, 0.4% synanthrin, 4% glucose and 0.3% microcrystalline cellulose adopt rotating speed, and the three-dimensional motion mixer that power of motor is 0.5Kw mixes;
Then utilize single-punching tablet press, the unit's of making viable count reaches (1.0-3.0) * 10
7～(1.0-3.0) * 10
9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum compressing tablet pressure of described tablet press machine: 15KN; Compressing tablet diameter:
sheet is heavily 1.5g; Hardness is at 4～7N.
Embodiment 5:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; After fresh hawthorn is cleaned to peeling, be cut into small pieces, then adopt respectively blast drier to be dried to constant weight at 70 ℃;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are mixed to rear employing by the mass ratio of 1:1:2:2 and meet operative norm Q/12NK4558-2006, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 70 object sieves and obtain mixture A;
3) probio is adopted under 37 ℃ of condition of culture the activation of MRS fluid nutrient medium obtain activating probio three times, the probio of getting after activation is accessed the fermentation tank culture 18h of 10L MRS culture medium with 5% inoculum concentration, in incubation, every 4h, stir once, turn/min of rotating speed 60, mixing time 2min, then, with centrifuge, with the centrifugal 12min of rotating speed of 10000 turn/min, make probiotics bacterial mud, then in probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL, utilize vortex mixed instrument to be mixed even, at-30 ℃ of pre-freeze 18h, move to again freeze drier freeze drying 24h and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant is by mass percentage by 50% skimmed milk power, 8% trehalose, and 1% sodium hydrogen phosphate, 1% lactose and 40% phosphate buffer form;
Wherein, the activation process of probio specifically comprises:
Lactobacillus acidophilus is adopted under 37 ℃ of condition of culture to MRS fluid nutrient medium activation three times, the cysteine hydrochloride that Bifidobacterium is added culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture, with 5% inoculum concentration, transfer at every turn, wherein all under 37 ℃ of condition of culture, cultivate 20-24h first twice, under 37 ℃ of condition of culture, cultivate 18h for the third time, then carry out microscopy, survey OD value, determine without activating for the third time and obtain activating probio after miscellaneous bacteria.
4) make solid content reach 45% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, after raw material sheep breast is dried (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) by spraying, cool to room temperature is crossed the sub goat milk powder that obtains of 70 mesh sieves;
5) by mass percentage by 74% goat milk powder, 15% mixture A, it is 8 turn/min that 0.5% dry probiotics bacterial powder, 5% sucrose, 1% synanthrin, 4% glucose and 0.5% microcrystalline cellulose adopt rotating speed, and the three-dimensional motion mixer that power of motor is 0.5Kw mixes;
Then utilize single-punching tablet press, the unit's of making viable count reaches (1.0-3.0) * 10
7～(1.0-3.0) * 10
9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum compressing tablet pressure of described tablet press machine: 15KN; Compressing tablet diameter:
sheet is heavily 1.6g; Hardness is at 4～7N.
Claims (10)
1. a stomach strengthening and digestion promoting probio goat milk sheet, it is characterized in that: the goat milk powder that comprises by mass percentage 53.5%-80.2%, the mixture A of 10%-30%, freeze-drying probiotics bacterial powder, the sucrose of 5%-7%, the glucose of the synanthrin of 0.5%-1.0%, 4%-7% and the microcrystalline cellulose of 0.2%-0.5% of 0.1%-1%;
Described mixture A is mixed to get by the mass ratio of 1:1:2:2 by the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn.
2. stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 1, is characterized in that: described freeze-drying probiotics bacterial powder is the mixture of probio and compound freeze drying protectant;
Wherein probio mixes with the ratio of the compound freeze drying protectant of 1mL according to every g probio with compound freeze drying protectant;
Wherein probio employing viable count is (1.0-3.0) * 10
11lactobacillus acidophilus bacterium powder, viable count be 1.0-3.0 * 10
11the Mixed Microbes of these two kinds of arbitrary proportions of bifidobacterium bifidum bacterium powder;
Compound freeze drying protectant comprises by mass percentage and comprising: the skimmed milk power of 18%-50%, the trehalose of 8%-20%, the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% phosphate buffer.
3. a preparation method for stomach strengthening and digestion promoting probio goat milk sheet, is characterized in that comprising the following steps:
1) will after the clean peeling of fresh hawthorn, be dried to constant weight;
2) be ground into after the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are mixed by the mass ratio of 1:1:2:2 Powderedly, then cross 40-80 object sieve and obtain mixture A;
3) probio of getting after activation is accessed the fermentation tank culture 18h of 10L MRS culture medium with 2～5% inoculum concentration, in incubation, every 3-4h, stir once, turn/min of rotating speed 60, mixing time 2min, then, with centrifuge, with the centrifugal 12min of rotating speed of 10000 turn/min, make probiotics bacterial mud, then in probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL, utilize vortex mixed instrument to be mixed even, at-40～-20 ℃ of pre-freeze 12～24h, then move to freeze drier freeze drying 24h acquisition freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant comprises: by mass percentage by the skimmed milk power of 18%-50%, the sodium hydrogen phosphate of the trehalose of 8%-20%, 1%-2%, the phosphate buffer of the lactose of 1%-10% and 40%-50% form;
4) by sheep breast through purify and standardization after, reduced pressure concentration makes solid content reach 42%～50% and obtains raw material sheep breast, by crossing 40～80 mesh sieves after spray dry and cool to room temperature, obtains goat milk powder;
5) by mass percentage by the goat milk powder of 53.5%-80.2%, the mixture A of 10%-30%, 0.1%-1% freeze-drying probiotics bacterial powder, the sucrose of 5%-7%, the synanthrin of synanthrin 0.5%-1.0%,, the microcrystalline cellulose of the glucose of 4%-7% and 0.2%-0.5% mixes, obtain mixture B;
Then utilize tablet press machine, the mixture B unit of making viable count is reached to (1.0-3.0) * 10
7～(1.0-3.0) * 10
9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn compound probiotic of cfu/g.
4. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 3, is characterized in that: the dry employing blast drier of described step 1) is dry at 70 ℃.
5. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 3, is characterized in that: described step 2) pulverize employing and meet operative norm Q/12NK4558-2006, power of motor is 1200W, and the medicinal herb grinder that rotating speed is 2400r/min is pulverized.
6. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 3, is characterized in that: described probio is that viable count is (1.0-3.0) * 10
11lactobacillus acidophilus bacterium powder, viable count be 1.0-3.0 * 10
11the mixing of these two kinds of arbitrary proportions of bifidobacterium bifidum bacterium powder.
7. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 3, is characterized in that: the activation process of described probio is as follows:
Lactobacillus acidophilus is adopted under 37 ℃ of condition of culture to MRS fluid nutrient medium activation three times, the cysteine hydrochloride that Bifidobacterium is added culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture, with 2～5% inoculum concentration, transfer at every turn, wherein all under 37 ℃ of condition of culture, cultivate 20-24h first twice, under 37 ℃ of condition of culture, cultivate 18h for the third time, then carry out microscopy, survey OD value, determine without activating for the third time and obtain activating probio after miscellaneous bacteria.
8. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 3, is characterized in that: the dry EAT of described spraying is 160～165 ℃, and temperature of outgoing air is 75～65 ℃.
9. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 3, is characterized in that: it is 5～20 turn/min that the mixing of described step 5) adopts rotating speed, the three-dimensional motion mixer that power of motor is 0.5Kw.
10. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 3, is characterized in that: the maximum compressing tablet pressure of described single-punching tablet press: 50KN; Compressing tablet diameter:
sheet is heavily 1.0～1.6g; Hardness is at 4～7N.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111194786A (en) * | 2020-03-02 | 2020-05-26 | 兰州大学 | Calcium milk tablet containing dangshen oligosaccharide and preparation method thereof |
| WO2022266650A1 (en) * | 2021-06-17 | 2022-12-22 | The Uab Research Foundation | Bacteria and herbal extract nutraceutical blends for lung health maintenance |
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| CN1824240A (en) * | 2006-01-12 | 2006-08-30 | 北京阜康仁生物制药科技有限公司 | Shenshu Jianpi medicinal preparation for invigorating spleen and its new preparation method |
| CN1895610A (en) * | 2006-06-26 | 2007-01-17 | 河南康鑫药业有限公司 | Preparation for digestant and nourishing-kidney tablets by micropowder technology |
| CN102742653A (en) * | 2012-07-10 | 2012-10-24 | 陕西科技大学 | Brain-strengthening and nerve soothing probiotic goat milk tablet and preparation method of brain-strengthening and nerve soothing probiotic goat milk tablet |
| CN102754695A (en) * | 2012-07-10 | 2012-10-31 | 陕西科技大学 | Burdock probiotics goat milk slices and method for preparing same |
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2014
- 2014-04-10 CN CN201410142871.7A patent/CN103918793B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1824240A (en) * | 2006-01-12 | 2006-08-30 | 北京阜康仁生物制药科技有限公司 | Shenshu Jianpi medicinal preparation for invigorating spleen and its new preparation method |
| CN1895610A (en) * | 2006-06-26 | 2007-01-17 | 河南康鑫药业有限公司 | Preparation for digestant and nourishing-kidney tablets by micropowder technology |
| CN102742653A (en) * | 2012-07-10 | 2012-10-24 | 陕西科技大学 | Brain-strengthening and nerve soothing probiotic goat milk tablet and preparation method of brain-strengthening and nerve soothing probiotic goat milk tablet |
| CN102754695A (en) * | 2012-07-10 | 2012-10-31 | 陕西科技大学 | Burdock probiotics goat milk slices and method for preparing same |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111194786A (en) * | 2020-03-02 | 2020-05-26 | 兰州大学 | Calcium milk tablet containing dangshen oligosaccharide and preparation method thereof |
| WO2022266650A1 (en) * | 2021-06-17 | 2022-12-22 | The Uab Research Foundation | Bacteria and herbal extract nutraceutical blends for lung health maintenance |
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| CN103918793B (en) | 2016-04-06 |
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Effective date of registration: 20181106 Address after: 712100 B7, Fuhai Industrial Park, Weihui East Road, Yangling demonstration area, Xianyang, Shaanxi Patentee after: Shaanxi British children's Dairy Co., Ltd. Address before: No. 1, Weiyang District university garden, Xi'an, Shaanxi Province, Shaanxi Patentee before: Shaanxi University of Science and Technology |
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