CN102742653A - Brain-strengthening and nerve soothing probiotic goat milk tablet and preparation method of brain-strengthening and nerve soothing probiotic goat milk tablet - Google Patents
Brain-strengthening and nerve soothing probiotic goat milk tablet and preparation method of brain-strengthening and nerve soothing probiotic goat milk tablet Download PDFInfo
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Abstract
The invention relates to a brain-strengthening and nerve soothing probiotic goat milk tablet and a preparation method of the brain-strengthening and nerve soothing probiotic goat milk tablet. The brain-strengthening and nerve soothing probiotic goat milk tablet comprises the following ingredients in percentage by mass: 53 percent to 78.9 percent of goat milk powder, 10 percent to 30 percent of a mixture A, 0.1 percent to 1 percent of freeze dry probiotic powder, 5 percent to 7 percent of cane sugar, 5 percent to 8 percent of glucose and 1 percent of magnesium stearate, wherein the mixture A is obtained through mixing flaxseed, walnut kernel and dry burdock according to a mass ratio being 1:2:2. The flaxseed, the walnut kernel, the burdock and the probiotic are added into goat milk, in addition, the materials are made into tablets, the effects of all ingredients are realized, and meanwhile, the carrying and the eating are also convenient.
Description
Technical field
The invention belongs to field of health care food, the present invention relates to a kind of invigorating brain and relieving mental uneasiness probio goat milk sheet and preparation method thereof.
Background technology:
Goat Milk is just published as far back as the seventies in last century the United Nations's food and agricultural organization (FAO) has " goat observation " (Observations On Goat) book; Wherein mention: " very early, Goat Milk has extensively been thought to be particularly suitable for the food that the elderly, sick people, sick convalescent people and infant use.Under many circumstances, when individuality produced allergy to milk, the use of Goat Milk not only can be removed allergic symptom, and the growth of health is grown according to normal speed ".Goat milk is existing to have many advantages for milk: 1. Goat Milk medium chain fatty acid content is high, wherein aliphatic acid be divided into long, in, three kinds of short chains.Medium chain and SCFA receive the attack of body fat enzyme more easily than long-chain and are digested and assimilated.In addition, medium chain fatty acid has unique mechanism of absorption, can directly be absorbed at small intestine without the digestion of pancreas enzyme and cholate, and the content of Goat Milk medium chain fatty acid is the twice of milk.2. Goat Milk fat globule diameter is little, and the diameter of fat globule is more little, just has bigger surface area to supply human intestine's lipase to attack, and fat is decomposed faster.In general, the digestion of Goat Milk is than milk fast 20%.Though milk and Goat Milk separately the diameter of fat globule have different,, on average, the diameter of Goat Milk fat globule is much littler than milk.On general, the diameter of Goat Milk fat globule is the 2-2.5 micron, and milk is the 3-4.25 micron.The digestion process of little, the frangible protein of curdled milk hardness in human body that Goat Milk forms is under the hydrochloric acid in gastric juice effect, to form curdled milk earlier, and the digestion that is decomposed then is absorbed at small intestine for amino acid afterwards.The soft durometer of ziega directly influences speed and the efficient that protein is digested.Main protein is beta-casein in the Goat Milk, with protein alpha-S1 casein main in the milk structural difference is arranged.It is soft more frangible than milk that the ziega that the Goat Milk beta-casein forms under one's belt has been proved to be.3. strengthen the absorption of iron and calcium.Iron in the milk and calcium can have influence on wherein a kind of absorption of element because interaction is arranged.And iron in the Goat Milk and calcium do not have this interaction, so bioavilability is higher than milk.
Probio (Probiotics); Claim probiotic, regulator again, give birth to rhzomorph, viable bacteria element etc.; Promptly be meant certain microorganism formulation or fermented product,, the host produced useful physiological action through regulating host's mucous membrane and systemic immune function and improving enteral nutrition and colony balance; Through growing the composition of a certain position of effect change host flora surely, help the single of host health effect or form clear and definite mixed microorganism thereby produce.Up to now, the probio that scientist has found can be divided into three major types substantially, comprising: 1. lactobacillus class (like lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, lactobacillus plantarum etc.); 2. Bifidobacterium class (like bifidobacterium longum, bifidobacterium adolescentis, bifidobacterium breve, bifidobacterium infantis etc.); 3. gram-positive cocci (like streptococcus fecalis, galactococcus, intermediary streptococcus etc.).Probio is as a frontier, and in recent years, the special physiological activity of probio is widely used in food, except that being applied to fermented dairy product, also just progressively is applied to developing various functional foods.At present, probio is mainly used in fields such as food, functional food, dietary supplements, medicinal organism goods and feed.Be referred to as probiotic food to the food that contains profitable probliotics, mainly comprise the food of direct interpolation probio and through the food of probiotics fermention.Probio the most general application in field of food is still the dairy products field, comprises acidified milk, active lactic acid bacteria drink, cheese, sour cream, kefyr, fruit juice, cereal preparation, biscuit etc.The probio bacterial classification of usefulness has Bifidobacterium (Bifidobateria), Bacillus acidi lactici and some streptococcus; Wherein, Bacillus acidi lactici is commonly used has lactobacillus acidophilus (Lactobicullus acidophilus), Lactobacillus casei (L.casei), lactobacillus bulgaricus (L.bulgaricus) etc.The probio bacterial classification that can be used for health food of China Ministry of Public Health approval at present has: lactobacillus acidophilus, Lactobacillus casei, lactobacillus reuteri, Lactobacillus rhamnosus, bifidobacterium bifidum, bifidobacterium infantis, bifidobacterium breve, bifidobacterium longum, blue and green Bifidobacterium, lactobacillus bulgaricus, streptococcus thermophilus etc.
Linseed is commonly called as flaxseed, and there has been more than 5,000 year history in it in human history.In linseed, ω-3 series fatty acid and α-linoleic content is very high, and ω-3 series fatty acid belongs to polynary non-saturated fatty acid; Being one of most important composition in the human body cell structure, also is the normally essential material of cell membrane running, therefore becomes essential fatty acid again; Because change has taken place in people in modern dietary structure custom; Absorb too much saturated fatty acid, the intake of unrighted acid reduces relatively, thus the illness rate of very big some diseases; Like angiocardiopathy, cancer, diabetes etc., and the ω in the linseed-3 series fatty acid can reduce the generation of above disease.Same α-linoleic acid also is human essential fatty acid, and it also is the picked-up that relies on food.Because DHA and EPA that ω-3 series fatty acid in the linseed and α-linoleic acid can transform through the effect of endoenzyme automatically, thereby play the effect of invigorating brain and relieving mental uneasiness after the human body absorption, be rich in dietary fiber in the linseed, but reducing blood lipid, blood pressure etc.
Walnut is claimed English walnut again, claims English walnut, Qiang peach again, with almond, cashew nut, fibert and be called world-renowned " four big dry fruits ".Walnut is not only delicious, and nutritive value is very high, is described as " long live ", " long-lived fruit ".According to surveying and determination, in per 100 gram walnuts, fatty 50～64 grams, the lipase 37 in the walnut 1% is a linoleic acid, and 12% is leukotrienes, and protein is 15～20 grams, and protein is high-quality protein also, fat and albumen are the best nutriments of brain in the walnut.Carbohydrate is 10 grams, and contains nutriments such as calcium, phosphorus, iron, carrotene, riboflavin (vitamin B2), vitamin B6, vitamin E, juglandis folia quinone, phosphatide, tannin.
Burdock has another name called white muscle genseng, the sticking root of mouse, black radiss, tree root dish etc., belongs to composite family Arctium biennial herb plant, is product with the fleshy root.Burdock is a kind of industrial crops, and good reputations such as " kings of vegetables ", " white muscle genseng ", " dali ginseng " are arranged.Burdock is precious, nutritious from head to foot, has multiple pharmacological effect, and the pharmacological action with burdock in " modern Chinese herbal medicine voluminous dictionary " is summarised as " antibiotic, anticancer, anti-ageing " three large effects.Be rich in necessary mineral matter of human body and amino acid such as polysaccharide, cellulose, carrotene, polyphenol, calcium, iron, zinc, magnesium in the radix bardanae, have higher medicine-food two-purpose to be worth.Polysaccharide is by the D-fructose of the furan type mixture through the synthetic levulan of glycosidic bond dehydration, has multiple biologically active, and functions such as the beneficial gas that is good for the stomach, diuresis, nourishing and strengthening vital, clearing heat and detoxicating, antibacterial, anti-inflammatory are arranged.Functions such as anti-curing oncoma, coronary heart disease, diabetes, colon disease and constipation are arranged simultaneously, in food, medical industry, have wide practical use.
In recent years; Linseed is applied to the report of food; It is the method for feedstock production beverage with the linseed that patent (CN 1166322C) has been announced a kind of, and burdock is applied to the existing report of food, and patent (CN 1110511A) has been announced the preparation method of health-care great burdock tea; Patent (CN 101218948A) has been announced health care beverage of edible burdock root; Patent (CN 1079123A) has been announced walnut kernel breast series beverage and industrialized preparing process thereof, is to drink, beverage etc. for the research great majority of linseed, burdock, walnut, but it is very few that linseed, burdock, walnut are given birth to the report that the factor is applied in the tablet as benefit.In recent years the health care dairy products are reported to some extent that also patent (CN 101199300A) has been announced a kind of prebiotics formula milk and preparation method thereof simultaneously, the interpolation material is a compound sugar.It passes through spray drying method for preparation dry powder then through fresh milk and batch mixes, and this patented invention just is implemented in the milk aspect, does not relate to aspect goat milk powder.The invention of this patent simultaneously only be with compound sugar as additive, do not relate to the compound substance (linseed, walnut kernel, burdock, lily etc.) that adds some mind-tranquilizing brain-strengthenings.Goat milk is compared with milk and many advantages is arranged simultaneously; Therefore in the goat milk sheet, adding the mind-tranquilizing brain-strengthening material can make people's brain tonic, repose; And can reduce some generations like diseases such as cardiovascular and cerebrovascular, cancers; Add probio, more can improve body immunity, therefore have huge development space potentiality.
Summary of the invention
The object of the present invention is to provide a kind of invigorating brain and relieving mental uneasiness probio goat milk sheet and preparation method thereof.
For achieving the above object, invigorating brain and relieving mental uneasiness probio goat milk sheet of the present invention comprises the goat milk powder of 53%-78.9% by mass percentage, the mixture A of 10%-30%, 0.1%-1% freeze-drying probiotics bacterial powder, 5%-7% sucrose, 5%-8% glucose and 1% dolomol;
The mass ratio mixing that described mixture A is done by 1:2:2 by linseed, walnut kernel and burdock obtains.
Described freeze-drying probiotics bacterial powder is the mixture of probio and compound freeze drying protectant;
The mixed of the compound freeze drying protectant of every g probio of probio and compound freeze drying protectant and 1mL wherein;
Wherein probio employing viable count is 1.0-3.0 * 10
11Lactobacillus acidophilus bacterium powder, viable count be 1.0-3.0 * 10
11Bifidobacterium bacterium powder, viable count be 1.0-3.0 * 10
10Lactobacillus plantarum bacterium powder, viable count be 1.0-3.0 * 10
10The Mixed Microbes of one or more arbitrary proportions of Lactobacillus rhamnosus bacterium powder;
Compound freeze drying protectant comprises the skimmed milk power of 18%-50% by mass percentage, the trehalose of 8%-20%, the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% phosphate buffer.
Preparation method of the present invention may further comprise the steps:
1) fresh walnut kernel is removed Cortex walnut and be dried to constant weight;
Fresh burdock is cut into the rectangular constant weight that is dried to that width is 5mm;
2) with linseed, walnut kernel, burdock are done and to be ground into Powderedly after mass ratio by 1:2:2 mixes, and cross 40-80 purpose sieve then and get mixture A;
3) get probio after the activation is inserted 10L MRS culture medium with 5% inoculum concentration fermentation tank culture 18h; Every separated 3-4h stirs once rotating speed 60 commentaries on classics/min, mixing time 2min in incubation; Then; Process probiotics bacterial mud with centrifuge with the centrifugal 12min of rotating speed of 8000 Zhuan ∕ min, in probiotics bacterial mud, add the compound freeze drying protectant of 1mL then by every g probio mud, it is even to utilize the vortex mixed instrument to be mixed; At-40～-20 ℃ of pre-freeze 12～24h, move to freeze drier freeze drying 24h again and obtain freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant is by mass percentage by the skimmed milk power of 18%-50%, the trehalose of 8%-20%, and the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% phosphate buffer are formed;
4) with sheep breast through purify and standardization after, decompression concentrates and makes solid content reach 42～50% to obtain raw material sheep breast, through behind spray-drying and the cool to room temperature 40～80 mesh sieves get goat milk powder;
5) by mass percentage with the goat milk powder of 53%-78.9%, the mixture A of 10%-30%, 0.1%-1% freeze-drying probiotics bacterial powder, 5%-7% sucrose, 5%-8% glucose and 1% dolomol mix;
Described mixture A does the mass ratio of pressing 1:2:2 by linseed, walnut kernel and burdock and mixes;
Utilize one-shot formula tablet press machine then, the unit's of processing viable count reaches 1.0-3.0 * 10
7～1.0-3.0 * 10
9Cfu/g contains linseed, walnut kernel, the invigorating brain and relieving mental uneasiness probio goat milk sheet of the dried composite powder probio of burdock.
The drying of said step 1) adopts blast drier 70 ℃ of dryings.
Said step 2) pulverize employing and meet operative norm Q/12NK4558-2006, power of motor is 1200W, and rotating speed is that the medicinal herb grinder of 2400r/min is pulverized.
Described probio is that viable count is 1.0-3.0 * 10
11Lactobacillus acidophilus bacterium powder, viable count be 1.0-3.0 * 10
11Bifidobacterium bacterium powder, viable count be 1.0-3.0 * 10
10Lactobacillus plantarum bacterium powder, viable count be 1.0-3.0 * 10
10The mixing of one or more arbitrary proportions of Lactobacillus rhamnosus bacterium powder.
The activation process of said probio is following:
Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus are adopted MRS fluid nutrient medium activation three times respectively under 37 ℃ of condition of culture; Bifidobacterium is added culture volume 0.05% in the MRS fluid nutrient medium cysteine hydrochloride adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture; Transfer with 5% inoculum concentration at every turn; All under 37 ℃ of condition of culture, cultivate 20-24h wherein preceding twice; Under 37 ℃ of condition of culture, cultivate 18h for the third time, carry out microscopy then, survey the OD value, confirm behind the assorted bacterium of nothing activation for the third time to be obtained the activation probio.
Described spray-drying EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃.
It is 5～20 commentaries on classics/min that rotating speed is adopted in described mixing, and power of motor is the three-dimensional motion mixer of 0.5Kw;
The maximum compressing tablet pressure of described one-shot formula tablet press machine: 15KN; Compressing tablet diameter: φ 8～14mm; In the sheet 0.4～0.6g; Hardness is at 4～6N.
The effect of invention
1) main component is a goat milk powder among the present invention; Because Goat Milk is rich in high quality protein matter and aliphatic acid and several mineral materials such as albumin that health is played an important role, globulin, bad syndrome patient has good health care and therapeutic action to nutrient absorption.Goat milk fat globule little (be merely milk 1/3), and be rich in be beneficial to that body directly utilizes in, the short chain unrighted acid, absorptivity is very high.The EGF that contains in the goat milk (EGF) when promoting epithelial cell growth, has repair to mucomembranous epithelial cells such as stomach, tracheae and skins; Can urge digestion again can tranquilizing and allaying excitement (because of containing cyclic nucleotide); But and enhancing body immunity, regulate the human body nutrient balance, improve sleep quality; The comfort cushioning characteristic of its meta-alkalescence also has the effect that promotes rehabilitation to diseases such as ephritis, tuberculosis and asthma, is infant, pregnant woman, old man and patient's excellent health products.
2) added probio in the present invention, probio has obvious facilitation to health, and it has following effect science proof: 1, prevent and improve constipation, diarrhoea; Safeguard enteron aisle normal bacteria colony balance, suppress growth of pathogenic bacteria, through bidirectional modulation; Prevent constipation; Diarrhoea, the adjustment function of intestinal canal is disorderly, prevents various intestines problems.2, antitumor, from the isolated antitumor polysaccharide of Bifidobacterium enzyme is lost activity, thus the generation of prophylaxis of cancer.3, the cholesterol in the control serum, a large amount of clinical trial both at home and abroad confirm, take the lactobacillary milk goods and have the human serum of minimizing cholesterol level, reduce the effect of cardiovascular disease incidence rate.1997, Gimland has proposed lactic acid bacteria at first can promote the catabolism of cholesterol through the degraded cholate, thereby reduced the viewpoint of cholesterol level.4, biological barrier effect reduces the generation of harmful substance in harmful bacterium metabolin, forms the biomembrane barrier that one deck has protective effect, stops the invasion of pernicious bacteria, accelerates the discharge of various toxin in the enteron aisle.Play the effect that improves intestinal environment and protection enteron aisle.5, promote the generation and the absorption of nutriment in the enteron aisle, synthetic vitamin B can self synthesized or promote to Bifidobacterium
1, B
2, B
6, B
12And the nutriment of needed by human such as amino acid., improve absorption to calcium ion, realize stomach normalization.6, row's stool, the fat that purifies the blood, hypotensive, quicken lipolysis, old loose fat in the adsorbent reduces serum cholesterol level.Thereby hypertension and artery sclerosis there is certain prevention effect.7, improve immunity, have the cytotostatic of promotion and increase the intestine immunity enhanced feature, prevent antibiotic side effect, the trigger cell mutation factor is had resistant function.Anti-ageing, promote longevity.8, improve lactose intolerance, the ferment that Bifidobacterium reduces lactose is to help improve lactose intolerance.9, other functions are like food hypersenstivity, prevention diabetes etc.Exactly because probio for the effect of human health, makes it receive much concern.
3) added linseed in the present invention; Because linseed is in linseed; ω-3 series fatty acid and α-linoleic content is very high, and ω-3 series fatty acid belongs to polynary non-saturated fatty acid, is one of most important composition in the human body cell structure; Belong to essential fatty acid, can reduce generation like angiocardiopathy, cancer, diabetes etc.DHA and EPA that ω in the linseed-3 series fatty acid and α-linoleic acid can transform through the effect of endoenzyme after human body is taken in automatically, thus play the effect of invigorating brain and relieving mental uneasiness, be rich in dietary fiber in the linseed, but reducing blood lipid, blood pressure etc.
4) added walnut kernel in the present invention; Owing to contain abundant linoleic acid, leukotrienes, high-quality protein in the walnut kernel; It is the DHA precursor of synthetic brain tonic; Through the picked-up linoleic acid, leukotrienes improves the content of DHA in the human body, plays the effect of brain tonic; Simultaneously contain nutriments such as abundant calcium, phosphorus, iron, carrotene, riboflavin (vitamin B2), vitamin B6, vitamin E, juglandis folia quinone, phosphatide, tannin in the walnut kernel, help effect insomnia, heart disease, cardiovascular and cerebrovascular disease etc. are all useful.
5) added burdock tea in the present invention,, can discharge vivotoxin because burdock tea contains rich dietary fiber; Also can slow down the energy that food discharges, assemble in vivo, accelerate the sour speed that reduces fat thereby weaken fat; It not only reduces cholesterol, promotes health of heart, and helps defaecation, drainage; Eliminate fast and the interior harmful metabolin piled up of prevention body, therefore very effectively toxin expelling, defaecation, lipopenicillinase, fat-reducing; Because burdock tea contains rich in protein, calcium, vitamin, wherein the content of carrotene is 150 times of carrot.So can replenish desired nutritional, these nutritional labelings can enhance metabolism, protein can improve body immunity, promotes the neonatal cell growth, has the antidotal function of preserving youthful looks.The contained nutritional labeling of burdock tea helps and keeps total balance of the body, regulates the bodily fuctions, anti-cancer is played an important role; Burdock tea has excellent prevention and inhibitory action etc. to three height, diabetes.
The specific embodiment
Further specify the present invention below in conjunction with embodiment:
Embodiment 1:
1) fresh walnut kernel is removed Cortex walnut, it is the rectangular of 5mm that fresh burdock is cut into width, adopts blast drier to be dried to constant weight at 70 ℃ then respectively;
2) with linseed; The mass ratio mixing back employing that walnut kernel, burdock are done by 1:2:2 meets operative norm Q/12NK4558-2006, and power of motor is 1200W; It is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and crosses 40 purpose sieves then and get mixture A;
3) at first, under 37 ℃ of condition of culture, adopt the activation of MRS fluid nutrient medium to obtain the activation probio three times the probio lactobacillus acidophilus, get lactobacillus acidophilus after the activation is inserted 10L MRS culture medium with 5% inoculum concentration fermentation tank culture 18h; Every separated 3h stirs once rotating speed 60 commentaries on classics/min, mixing time 2min in incubation; Then; Process probiotics bacterial mud with centrifuge with the centrifugal 12min of rotating speed of 8000 Zhuan ∕ min, in probiotics bacterial mud, add the compound freeze drying protectant of 1mL then by every g probio mud, it is even to utilize the vortex mixed instrument to be mixed; At-40 ℃ of pre-freeze 12h, move to freeze drier freeze drying 24h again and obtain freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant is by mass percentage by 18% skimmed milk power, 20% trehalose, and 2% sodium hydrogen phosphate, 10% lactose and 50% phosphate buffer are formed;
4) with raw material sheep breast through purify and standardization after decompression concentrate make solid content reach 42% the raw material sheep is newborn; Raw material sheep breast is crossed 40 mesh through spray-drying (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) back cool to room temperature and is got goat milk powder;
5) by mass percentage with 53% goat milk powder, 30% mixture A, it is 5 commentaries on classics/min that 1% freeze-drying probiotics bacterial powder, 7% sucrose, 8% glucose and 1% dolomol adopt rotating speed, power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Utilize one-shot formula tablet press machine then, the unit's of processing viable count reaches 1.0-3.0 * 10
7～1.0-3.0 * 10
9Cfu/g contains linseed, walnut kernel, the invigorating brain and relieving mental uneasiness probio goat milk sheet of the dried composite powder probio of burdock.
The maximum compressing tablet pressure of described tablet press machine: 15KN; Compressing tablet diameter: φ 8mm; In the sheet 0.4g; Hardness is at 4～6N.
Embodiment 2:
1) fresh walnut kernel is removed Cortex walnut, it is the rectangular of 5mm that fresh burdock is cut into width, adopts blast drier to be dried to constant weight at 70 ℃ then respectively;
2) with linseed; The mass ratio mixing back employing that walnut kernel, burdock are done by 1:2:2 meets operative norm Q/12NK4558-2006, and power of motor is 1200W; It is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and crosses 60 purpose sieves then and get mixture A;
3) at first; Under 37 ℃ of condition of culture, adopt the activation of MRS fluid nutrient medium to obtain the activation probio three times respectively probio lactobacillus acidophilus, Lactobacillus plantarum, get lactobacillus acidophilus after the activation, Lactobacillus plantarum and insert the fermentation tank culture 18h of 10L MRS culture medium, whenever in incubation stir once at a distance from 4h with 5% inoculum concentration; Rotating speed 60 commentaries on classics/min; Mixing time 2min then, processes probiotics bacterial mud with centrifuge with the centrifugal 12min of rotating speed of 8000 Zhuan ∕ min; In probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL then; It is even to utilize the vortex mixed instrument to be mixed, and at-30 ℃ of pre-freeze 18h, moves to freeze drier freeze drying 24h again and obtains freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant is by mass percentage by 50% skimmed milk power, 8% trehalose, and 1% sodium hydrogen phosphate, 1% lactose and 40% phosphate buffer are formed;
4) with raw material sheep breast through purify and standardization after decompression concentrate make solid content reach 45% the raw material sheep is newborn; Raw material sheep breast is crossed 60 mesh through spray-drying (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) back cool to room temperature and is got goat milk powder;
5) by mass percentage with 78.9% goat milk powder, 10% mixture A, it is 8 commentaries on classics/min that 0.1% freeze-drying probiotics bacterial powder, 5% sucrose, 5% glucose and 1% dolomol adopt rotating speed, power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Utilize one-shot formula tablet press machine then, the unit's of processing viable count reaches 1.0-3.0 * 10
7～1.0-3.0 * 10
9Cfu/g contains linseed, walnut kernel, the invigorating brain and relieving mental uneasiness probio goat milk sheet of the dried composite powder probio of burdock.
The maximum compressing tablet pressure of described tablet press machine: 15KN; Compressing tablet diameter: φ 10mm; In the sheet 0.5g; Hardness is at 4～6N.
Embodiment 3:
1) fresh walnut kernel is removed Cortex walnut, it is the rectangular of 5mm that fresh burdock is cut into width, adopts blast drier to be dried to constant weight at 70 ℃ then respectively;
2) with linseed; The mass ratio mixing back employing that walnut kernel, burdock are done by 1:2:2 meets operative norm Q/12NK4558-2006, and power of motor is 1200W; It is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and crosses 80 purpose sieves then and get mixture A;
3) at first; Under 37 ℃ of condition of culture, adopt the activation of MRS fluid nutrient medium to obtain the activation probio three times respectively probio lactobacillus acidophilus, Lactobacillus plantarum and Lactobacillus rhamnosus, lactobacillus acidophilus, Lactobacillus plantarum and the Lactobacillus rhamnosus of getting after the activation are inserted the fermentation tank culture 18h of 10L MRS culture medium with 5% inoculum concentration, whenever in incubation stir once at a distance from 4h; Rotating speed 60 commentaries on classics/min; Mixing time 2min then, processes probiotics bacterial mud with centrifuge with the centrifugal 12min of rotating speed of 8000 Zhuan ∕ min; In probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL then; It is even to utilize the vortex mixed instrument to be mixed, and at-25 ℃ of pre-freeze 21h, moves to freeze drier freeze drying 24h again and obtains freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant is by mass percentage by 30% skimmed milk power, 15% trehalose, and 1.5% sodium hydrogen phosphate, 5% lactose and 48.5% phosphate buffer are formed;
4) with raw material sheep breast through purify and standardization after decompression concentrate make solid content reach 48% the raw material sheep is newborn; Raw material sheep breast is crossed 80 mesh through spray-drying (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) back cool to room temperature and is got goat milk powder;
5) by mass percentage with 60% goat milk powder, 25% mixture A, it is 12 commentaries on classics/min that 0.5% freeze-drying probiotics bacterial powder, 6.5% sucrose, 7% glucose and 1% dolomol adopt rotating speed, power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Utilize one-shot formula tablet press machine then, the unit's of processing viable count reaches 1.0-3.0 * 10
7～1.0-3.0 * 10
9Cfu/g contains linseed, walnut kernel, the invigorating brain and relieving mental uneasiness probio goat milk sheet of the dried composite powder probio of burdock.
The maximum compressing tablet pressure of described tablet press machine: 15KN; Compressing tablet diameter: φ 12mm; In the sheet 0.55g; Hardness is at 4～6N.
Embodiment 4:
1) fresh walnut kernel is removed Cortex walnut, it is the rectangular of 5mm that fresh burdock is cut into width, adopts blast drier to be dried to constant weight at 70 ℃ then respectively;
2) with linseed; The mass ratio mixing back employing that walnut kernel, burdock are done by 1:2:2 meets operative norm Q/12NK4558-2006, and power of motor is 1200W; It is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and crosses 50 purpose sieves then and get mixture A;
3) at first, under 37 ℃ of condition of culture, adopt the activation of MRS fluid nutrient medium to obtain the activation probio three times the probio lactobacillus acidophilus, Bifidobacterium is added culture volume 0.05% in the MRS fluid nutrient medium cysteine hydrochloride adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture; At every turn with 5% inoculum concentration switching, wherein preceding twice all cultivation 20h under 37 ℃ of condition of culture, cultivation 18h under 37 ℃ of condition of culture for the third time; Carry out microscopy then, survey the OD value; After confirm having assorted bacterium activation is not for the third time obtained the activation probio, lactobacillus acidophilus and the Bifidobacterium of getting after the activation are inserted the fermentation tank culture 18h of 10L MRS (adding the cysteine hydrochloride of 5g in the MRS culture medium) culture medium with 5% inoculum concentration, and every separated 3h stirring once in incubation; Rotating speed 60 commentaries on classics/min; Mixing time 2min then, processes probiotics bacterial mud with centrifuge with the centrifugal 12min of rotating speed of 8000 Zhuan ∕ min; In probiotics bacterial mud, press the compound freeze drying protectant that every g probio mud adds 1mL then; It is even to utilize the vortex mixed instrument to be mixed, and at-35 ℃ of pre-freeze 15h, moves to freeze drier freeze drying 24h again and obtains freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant is by mass percentage by 40% skimmed milk power, 12% trehalose, and 1% sodium hydrogen phosphate, 3% lactose and 44% phosphate buffer are formed;
4) with raw material sheep breast through purify and standardization after decompression concentrate make solid content reach 46% the raw material sheep is newborn; Raw material sheep breast is crossed 50 mesh through spray-drying (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) back cool to room temperature and is got goat milk powder;
5) by mass percentage with 70% goat milk powder, 16% mixture A, it is 15 commentaries on classics/min that 0.8% freeze-drying probiotics bacterial powder, 6% sucrose, 6.2% glucose and 1% dolomol adopt rotating speed, power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Utilize one-shot formula tablet press machine then, the unit's of processing viable count reaches 1.0-3.0 * 10
7～1.0-3.0 * 10
9Cfu/g contains linseed, walnut kernel, the invigorating brain and relieving mental uneasiness probio goat milk sheet of the dried composite powder probio of burdock.
The maximum compressing tablet pressure of described tablet press machine: 15KN; Compressing tablet diameter: φ 14mm; In the sheet 0.6g; Hardness is at 4～6N.
Embodiment 5:
1) fresh walnut kernel is removed Cortex walnut, it is the rectangular of 5mm that fresh burdock is cut into width, adopts blast drier to be dried to constant weight at 70 ℃ then respectively;
2) with linseed; The mass ratio mixing back employing that walnut kernel, burdock are done by 1:2:2 meets operative norm Q/12NK4558-2006, and power of motor is 1200W; It is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and crosses 70 purpose sieves then and get mixture A;
3) at first; Under 37 ℃ of condition of culture, adopt the activation of MRS fluid nutrient medium to obtain the activation probio three times respectively probio lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium is added culture volume 0.05% in the MRS fluid nutrient medium cysteine hydrochloride adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture, transfer with 5% inoculum concentration at every turn; All under 37 ℃ of condition of culture, cultivate 24h wherein preceding twice; Under 37 ℃ of condition of culture, cultivate 18h for the third time, carry out microscopy then, survey the OD value, confirm behind the assorted bacterium of nothing activation for the third time to be obtained the activation probio; Get lactobacillus acidophilus, Lactobacillus plantarum and Bifidobacterium after the activation inserted 10L MRS (adding the cysteine hydrochloride of 5g in the MRS culture medium) culture medium with 5% inoculum concentration fermentation tank culture 18h; Every separated 4h stirs once rotating speed 60 commentaries on classics/min, mixing time 2min in incubation; Then; Process probiotics bacterial mud with centrifuge with the centrifugal 12min of rotating speed of 8000 Zhuan ∕ min, in probiotics bacterial mud, add the compound freeze drying protectant of 1mL then by every g probio mud, it is even to utilize the vortex mixed instrument to be mixed; At-20 ℃ of pre-freeze 24h, move to freeze drier freeze drying 24h again and obtain freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant is by mass percentage by 35% skimmed milk power, 15% trehalose, and 1% sodium hydrogen phosphate, 8% lactose and 41% phosphate buffer are formed;
4) with raw material sheep breast through purify and standardization after decompression concentrate make solid content reach 50% the raw material sheep is newborn; Raw material sheep breast is crossed 70 mesh through spray-drying (EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃) back cool to room temperature and is got goat milk powder;
5) by mass percentage with 63% goat milk powder, 20% mixture A, it is 20 commentaries on classics/min that 1% freeze-drying probiotics bacterial powder, 7% sucrose, 8% glucose and 1% dolomol adopt rotating speed, power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Utilize one-shot formula tablet press machine then, the unit's of processing viable count reaches 1.0-3.0 * 10
7～1.0-3.0 * 10
9Cfu/g contains linseed, walnut kernel, the invigorating brain and relieving mental uneasiness probio goat milk sheet of the dried composite powder probio of burdock.
The maximum compressing tablet pressure of described tablet press machine: 15KN; Compressing tablet diameter: φ 10mm; In the sheet 0.5g; Hardness is at 4～6N.
Claims (10)
1. invigorating brain and relieving mental uneasiness probio goat milk sheet is characterized in that: comprise the goat milk powder of 53%-78.9% by mass percentage, the mixture A of 10%-30%, 0.1%-1% freeze-drying probiotics bacterial powder, 5%-7% sucrose, 5%-8% glucose and 1% dolomol;
The mass ratio mixing that described mixture A is done by 1:2:2 by linseed, walnut kernel and burdock obtains.
2. invigorating brain and relieving mental uneasiness probio goat milk sheet as claimed in claim 1, it is characterized in that: described freeze-drying probiotics bacterial powder is the mixture of probio and compound freeze drying protectant;
The mixed of the compound freeze drying protectant of every g probio of probio and compound freeze drying protectant and 1mL wherein;
Wherein probio employing viable count is 1.0-3.0 * 10
11Lactobacillus acidophilus bacterium powder, viable count be 1.0-3.0 * 10
11Bifidobacterium bacterium powder, viable count be 1.0-3.0 * 10
10Lactobacillus plantarum bacterium powder, viable count be 1.0-3.0 * 10
10The Mixed Microbes of one or more arbitrary proportions of Lactobacillus rhamnosus bacterium powder;
Compound freeze drying protectant comprises the skimmed milk power of 18%-50% by mass percentage, the trehalose of 8%-20%, the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% phosphate buffer.
3. the preparation method of an invigorating brain and relieving mental uneasiness probio goat milk sheet is characterized in that may further comprise the steps:
1) fresh walnut kernel is removed Cortex walnut and be dried to constant weight;
Fresh burdock is cut into the rectangular constant weight that is dried to that width is 5mm;
2) with linseed, walnut kernel, burdock are done and to be ground into Powderedly after mass ratio by 1:2:2 mixes, and cross 40-80 purpose sieve then and get mixture A;
3) get probio after the activation is inserted 10L MRS culture medium with 5% inoculum concentration fermentation tank culture 18h; Every separated 3-4h stirs once rotating speed 60 commentaries on classics/min, mixing time 2min in incubation; Then; Process probiotics bacterial mud with centrifuge with the centrifugal 12min of rotating speed of 8000 Zhuan ∕ min, in probiotics bacterial mud, add the compound freeze drying protectant of 1mL then by every g probio mud, it is even to utilize the vortex mixed instrument to be mixed; At-40～-20 ℃ of pre-freeze 12～24h, move to freeze drier freeze drying 24h again and obtain freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant is by mass percentage by the skimmed milk power of 18%-50%, the trehalose of 8%-20%, and the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% phosphate buffer are formed;
4) with sheep breast through purify and standardization after, decompression concentrates and makes solid content reach 42～50% to obtain raw material sheep breast, through behind spray-drying and the cool to room temperature 40～80 mesh sieves get goat milk powder;
5) by mass percentage with the goat milk powder of 53%-78.9%, the mixture A of 10%-30%, 0.1%-1% freeze-drying probiotics bacterial powder, 5%-7% sucrose, 5%-8% glucose and 1% dolomol mix;
Utilize one-shot formula tablet press machine then, the unit's of processing viable count reaches 1.0-3.0 * 10
7～1.0-3.0 * 10
9Cfu/g contains linseed, walnut kernel, the invigorating brain and relieving mental uneasiness probio goat milk sheet of the dried composite powder probio of burdock.
4. the preparation method of invigorating brain and relieving mental uneasiness probio goat milk sheet as claimed in claim 3 is characterized in that: the drying of said step 1) adopts blast drier 70 ℃ of dryings.
5. the preparation method of invigorating brain and relieving mental uneasiness probio goat milk sheet as claimed in claim 3 is characterized in that: said step 2) pulverize employing and meet operative norm Q/12NK4558-2006, power of motor is 1200W, and rotating speed is that the medicinal herb grinder of 2400r/min is pulverized.
6. the preparation method of invigorating brain and relieving mental uneasiness probio goat milk sheet as claimed in claim 3 is characterized in that: described probio is that viable count is 1.0-3.0 * 10
11Lactobacillus acidophilus bacterium powder, viable count be 1.0-3.0 * 10
11Bifidobacterium bacterium powder, viable count be 1.0-3.0 * 10
10Lactobacillus plantarum bacterium powder, viable count be 1.0-3.0 * 10
10The mixing of one or more arbitrary proportions of Lactobacillus rhamnosus bacterium powder.
7. the preparation method of invigorating brain and relieving mental uneasiness probio goat milk sheet as claimed in claim 3, it is characterized in that: the activation process of said probio is following:
Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus are adopted MRS fluid nutrient medium activation three times respectively under 37 ℃ of condition of culture; Bifidobacterium is added culture volume 0.05% in the MRS fluid nutrient medium cysteine hydrochloride adopts MRS fluid nutrient medium activation three times under 37 ℃ of condition of culture; Transfer with 5% inoculum concentration at every turn; All under 37 ℃ of condition of culture, cultivate 20-24h wherein preceding twice; Under 37 ℃ of condition of culture, cultivate 18h for the third time, carry out microscopy then, survey the OD value, confirm behind the assorted bacterium of nothing activation for the third time to be obtained the activation probio.
8. the preparation method of invigorating brain and relieving mental uneasiness probio goat milk sheet as claimed in claim 3 is characterized in that: described spray-drying EAT is 160～165 ℃, and temperature of outgoing air is 75～65 ℃.
9. the preparation method of invigorating brain and relieving mental uneasiness probio goat milk sheet as claimed in claim 3 is characterized in that: it is 5～20 commentaries on classics/min that rotating speed is adopted in the mixing of said step 5), and power of motor is the three-dimensional motion mixer of 0.5Kw.
10. the preparation method of invigorating brain and relieving mental uneasiness probio goat milk sheet as claimed in claim 3 is characterized in that: the maximum compressing tablet pressure of described one-shot formula tablet press machine: 15KN; Compressing tablet diameter: φ 8～14mm; In the sheet 0.4～0.6g; Hardness is at 4～6N.
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| CN103918793A (en) * | 2014-04-10 | 2014-07-16 | 陕西科技大学 | Stomach-invigorating and digestion-helping probiotics goat milk tablet and preparation method thereof |
| CN103918795A (en) * | 2014-04-10 | 2014-07-16 | 陕西科技大学 | Tea polyphenols probiotics goat milk tablet and preparation method thereof |
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| CN103918795A (en) * | 2014-04-10 | 2014-07-16 | 陕西科技大学 | Tea polyphenols probiotics goat milk tablet and preparation method thereof |
| CN103918793B (en) * | 2014-04-10 | 2016-04-06 | 陕西科技大学 | A kind of stomach strengthening and digestion promoting probio goat milk sheet and preparation method thereof |
| CN104489106A (en) * | 2014-11-23 | 2015-04-08 | 江苏天目湖南山竹海食品有限公司 | Sheep colostrum composite powder for patients with cardiac neurosis |
| WO2022182220A1 (en) * | 2021-02-26 | 2022-09-01 | Leal Martinez Fernando | Nutritional support system for activating altered metabolic pathways |
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| CN102742653B (en) | 2013-12-25 |
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Effective date of registration: 20181106 Address after: 712100 B7, Fuhai Industrial Park, Weihui East Road, Yangling demonstration area, Xianyang, Shaanxi Patentee after: Shaanxi British children's Dairy Co., Ltd. Address before: No. 1, Weiyang District university garden, Xi'an, Shaanxi Province, Shaanxi Patentee before: Shaanxi University of Science and Technology |
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