KR102305931B1 - A food composition for improving circulation of blood and increasing functions of immune comprising natural extracts - Google Patents

Abstract

The present invention relates to a food composition with blood circulation and immune enhancement effects including natural extracts. According to the present invention, the composition comprising seaweed calcium, a galangal extract powder, a red ginseng concentrate powder, an Astragalus membranaceus Bunge extract powder, an Atractylodes japonica Koidzumi root powder, a Hooker chives powder, lactic acid bacteria, and a moringa extract powder as active ingredients provides an effect of inhibiting platelet aggregation to inhibit thrombus formation and an effect of inducing vasodilation by inhibiting constriction of blood vessels. In addition, an effect of suppressing an increase in cholesterol to reduce blood and liver lipids is recognized. Accordingly, through these effects, the food composition is effective in enhancing blood circulation, promotes vascular health, and can be effectively used for treatment or prevention of obesity, diabetes, hyperlipidemia, and the like. In addition, the food composition is effective in enhancing immunity, provides anti-obesity and anti-inflammatory effects as well as fatigue recovery and digestive function improvement effects.

Description

Food composition comprising a natural extract having the effect of improving blood circulation and enhancing immunity {A FOOD COMPOSITION FOR IMPROVING CIRCULATION OF BLOOD AND INCREASING FUNCTIONS OF IMMUNE COMPRISING NATURAL EXTRACTS}

The present invention relates to a composition containing a natural extract having the effect of improving blood circulation and enhancing immunity, and more specifically, seaweed calcium, galangal extract powder, red ginseng concentrate powder, astragalus extract powder, baekchul extract powder, samchae It relates to a food composition comprising extract powder, lactic acid bacteria and moringa extract powder as active ingredients, which has effects of improving blood circulation and enhancing immunity, as well as preventing drowsiness, improving fatigue, improving digestion and preventing obesity.

Due to recent rapid social change and rapid growth, modern people are exposed to excessive stress and negative health environments. In particular, lack of exercise, stress, and unbalanced intake of nutrition are aggravating the health of modern people, and are a major cause of increasing the incidence of various adult diseases and chronic diseases.

In addition, interest in ginseng products, a health functional food, is increasing at home and abroad as a way to increase stress in a competitive society, pursue an active lifestyle, and increase work efficiency by concentrating on each job for a longer period of time. The consumption of ginseng products in various forms such as pills, tablets, tea, and energy drinks is increasing. Among various types of ginseng products distributed recently, consumption of ginseng extract and energy drinks in pouches is increasing due to their easy intake.

Red ginseng, known as a representative health functional material, is the steamed and dried root of ginseng (Panaxginseng C. A. Meyer) and contains various saponins called ginsenosides. Red ginseng contains various physiologically active ingredients that are good for the body, and these ingredients are unique to red ginseng that fresh ginseng or white ginseng does not have, and can help strengthen immune function and improve constitution. Specifically, red ginseng contains maltol, an antioxidant component not found in white ginseng, various amino acids, organic fatty acids, and the like, and these components are effective in restoring vitality, enhancing immunity, and nourishing. In addition, red ginseng changes the chemical structure of a component called ginsenoside contained in ginseng during the manufacturing process. As a new ingredient that was absent or had very little content is newly created, it has various effects. However, because of the unique taste of red ginseng, there is a problem that the drinker feels objectionable.

As a patent document related to such red ginseng, for example, Korean Patent Publication No. 10-2018-0053009 discloses a health drink composition containing red ginseng and aronia, and Korean Patent Registration No. 10-1717755 discloses a health drink of red ginseng. A manufacturing method and a red ginseng health drink prepared by the above method have been disclosed.

On the other hand, according to the change of the eating pattern, modern people have relatively insufficient amount of exercise even though the amount of fat intake is increased, and they are living under various stresses. Due to these dietary changes, diseases such as hypertension, arteriosclerosis, or blood circulation disorders are on the rise. In particular, blood circulation disorders are known to cause symptoms such as memory loss, lethargy, weakness in concentration, and chronic fatigue.

Blood circulation refers to a phenomenon in which the blood in the body flows in a certain direction. In a blood circulation disorder, the blood vessels lose elasticity, cholesterol, etc. are deposited on the inner wall, and the level of waste products increases, which reduces the fluidity of the blood, and the inside of the blood vessels narrows. It means that the circulation is not done smoothly.

Diseases caused by blood circulation disorders include cardiovascular diseases such as hyperlipidemia, arteriosclerosis, myocardial infarction or cerebral thrombosis. Among cardiovascular diseases, hypertension, arteriosclerosis, heart disease, or stroke are considered as one of the leading causes of death among the elderly.

As such, if blood circulation disorders are left unattended, it may be difficult to maintain a normal life, and in severe cases, various types of diseases may develop and lead to death. Therefore, it can be seen that prevention rather than treatment of diseases caused by blood circulation disorders is more important.

On the other hand, the immune response is a response to all substances that enter our body from the outside. In particular, since microorganisms, which are living organisms, are directly or indirectly related to the occurrence of diseases, the immune response to these is very important to the host.

Due to the complexity of modern society and advanced industries, various mutagenic carcinogens are close to living space, and the mutation of normal human genes or genes such as viruses has accelerated due to such mutant carcinogens. In the end, although drugs have been developed, the function of immune cells is weakened due to the modification of genes and the virus is getting stronger, causing more and more problems. As such, the weakening of immunity caused by modern people's eating habits or environmental pollution is easily exposed to infectious diseases such as measles and flu, cancer, congenital malformations, immune system defects, and many fatal diseases caused by the invasion of stronger viruses and external microorganisms. result in becoming

Accordingly, the present inventors found that a composition comprising seaweed calcium, galangal extract powder, red ginseng concentrate powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder as active ingredients improves blood circulation and improves immunity. However, the present invention was completed by discovering the fact that it has effects of preventing drowsiness, improving fatigue, improving digestive function, and preventing obesity.

Therefore, the technical problem to be solved in the present invention is to provide a food composition containing a natural extract excellent in human body stability while having effects of improving blood circulation and enhancing immunity as well as preventing drowsiness, improving fatigue, improving digestion and preventing obesity. it is for

In order to solve the above technical problem, in the present invention, a food composition comprising seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder as active ingredients provides

Preferably, the composition contains 12 to 18 parts by weight of galangal extract powder, 20 to 25 parts by weight of red ginseng concentrated powder, 12 to 18 parts by weight of astragalus extract powder, 5 to 8 parts by weight of baekchul extract powder, based on 100 parts by weight of seaweed calcium; It is characterized in that it is mixed in an amount of 2 to 3 parts by weight of the three-chae extract powder, 2 to 3 parts by weight of lactic acid bacteria, and 2 to 3 parts by weight of the Moringa extract powder.

According to one embodiment of the present invention, the composition is characterized in that vitamin B1 hydrochloride, vitamin E, vitamin D, fructooligosaccharide, silicon dioxide or colostrum protein is additionally added.

Preferably, the composition is characterized in that it has the effect of improving blood circulation and enhancing immunity.

Preferably, the composition is characterized in that it has an effect of preventing drowsiness, improving fatigue, improving digestive function and preventing obesity.

Preferably, the food composition in the present invention may be in the form of a jelly.

As such, the composition comprising seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder of the present invention as an active ingredient inhibits platelet aggregation to prevent thrombosis It has the effect of inhibiting the production and has the effect of inducing vasodilation by inhibiting the constriction of blood vessels. In addition, the efficacy of suppressing an increase in cholesterol to reduce blood and liver lipids is recognized. Therefore, through this efficacy, it is effective for improving blood circulation, and not only improves vascular health, but also can be effectively used for treatment or prevention of obesity, diabetes, and hyperlipidemia. In addition, the composition of the present invention is very effective in enhancing immunity, and has anti-obesity and anti-inflammatory effects as well as fatigue recovery and digestive function improvement effects.

Hereinafter, the present invention will be described in more detail.

The present invention provides a food composition comprising seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder as active ingredients.

Preferably, the composition contains 12 to 18 parts by weight of galangal extract powder, 20 to 25 parts by weight of red ginseng concentrated powder, 12 to 18 parts by weight of astragalus extract powder, 5 to 8 parts by weight of baekchul extract powder, based on 100 parts by weight of seaweed calcium; It is characterized in that it is mixed in an amount of 2 to 3 parts by weight of the three-chae extract powder, 2 to 3 parts by weight of lactic acid bacteria, and 2 to 3 parts by weight of the Moringa extract powder.

According to one embodiment of the present invention, the composition is characterized in that vitamin B1 hydrochloride, vitamin E, vitamin D, fructooligosaccharide, silicon dioxide or colostrum protein is additionally added.

Preferably, the composition is characterized in that it has the effect of improving blood circulation and enhancing immunity.

Preferably, the composition is characterized in that it has an effect of preventing drowsiness, improving fatigue, improving digestive function and preventing obesity.

Preferably, the food composition in the present invention may be in the form of a jelly.

As used herein, the term "extract" refers to a preparation obtained by squeezing a herbal medicine with an appropriate leachate and evaporating the leachate, and is not limited thereto. It may be a dried product obtained by drying, a crude product thereof, or a purified product.

The natural extract of the present invention can be prepared using general extraction methods, separation and purification methods known in the art. As the extraction method, a method such as hot water extraction, hot water extraction, cold extraction, reflux cooling extraction, or ultrasonic extraction may be used, but is not limited thereto.

According to a specific embodiment of the present invention, the natural extract is used by pulverizing a natural plant as it is, or after drying and pulverizing using a hot air dryer or freeze dryer, an extraction solvent such as water, anhydrous or hydrous lower alcohol having 1 to 3 carbon atoms and a solvent selected from the group consisting of a mixed solvent thereof may be extracted using an extraction solvent, preferably water or ethanol, and the amount of the extraction solvent is 2 to 20 times the dry weight of the natural plant, preferably 5 to 15 weight times.

According to a specific embodiment of the present invention, the natural extract is pulverized and used as it is, or dried using a hot air dryer or freeze dryer and then pulverized using water or a mixture of water and alcohol at room temperature for 2 to 10 days, Preferably, extraction is carried out for 7 days, then filtered with filter paper and concentrated to separate water-soluble components and alcohol-soluble components, and water-soluble components and alcohol-soluble components are mixed in a weight ratio of 5:4 to obtain each natural extract. have.

Seaweed calcium used in the present invention is naturally-derived calcium and contains other minerals to help the absorption of calcium, and as a mineral itself, useful functions to the human body can be expected. Seaweed calcium is a natural organic calcium produced from seaweed and has better absorption capacity than general synthetic calcium preparations, which are water-soluble and insoluble calcium (Sun ju. Yu., Effect of calcium supplementation combined with or without fucoidan and chitooligosaccharide on bone status and calcium utilization in ovariectomized rat, Kangwon National University, 2011). In addition, the texture of the meat quality is not softened and the chewy texture can be maintained.

Galanga (Kaempferia galanga L) used in the present invention, also called sanna (山奈) or sagang (沙薑), is a perennial shrub belonging to the ginger family. It has a rhizome in the form of a finger-thick tuber and resembles ginger, but is smaller and has a darker color. The leaves grow directly from the root and are oval in shape and attach flat to the ground. It is cultivated in Indonesia and southern China. It is used as a seasoning for food or used in the manufacture of alcoholic beverages. In China, it is used to treat indigestion, headaches and colds. The root contains about 2.5-4% of essential oil and mainly contains a lot of ethyl ester of para-methoxycinnamate.

Red ginseng used in the present invention uses ginseng (Panax ginseng CA Meyer) as a raw material and steams or other methods to steam and dry undried fresh ginseng. It has a preventive effect on hypertension and arteriosclerosis. In addition, it lowers hematopoiesis and blood sugar levels, protects the liver, and acts on the endocrine system to indirectly and effectively act on sexual behavior and reproductive effects, and has anti-inflammatory and It has anti-tumor action (抗腫瘍作用), has a protective effect against radiation, protects the skin and softens it. According to the data presented by the Nutrition and Functional Food Standards Division of the Ministry of Food and Drug Safety, ginseng and red ginseng, centered on human application tests conducted so far, have functional properties such as fatigue recovery, immunity enhancement, memory enhancement, and blood flow through inhibition of platelet aggregation. This was acknowledged. In addition, it is known to have medicinal effects such as blood sugar lowering action, antioxidant action, and wound healing.

The astragalus (astragali radix) used in the present invention lives in Manchuria, northeastern China, and Japan mainly in Korea. Astragalus root is widely used for food, and Astragalus root, cultivated as a medicinal herb, is harvested in autumn, and the outcrops and fine roots formed from flowers are removed and dried in the sun. A distinctive feature of Astragalus is that its roots are very long. In other words, since the roots of astragalus are buried deeper in the ground than any other medicinal plant, a fork crane is sometimes mobilized when it is time to dig up the roots of astragalus. In this way, Astragalus has long roots to sustain life by pulling up moisture from the ground. If we compare it to the human body, it can be said that it is the same as moving the blood that sustains human life as a qi. Therefore, Astragalus is widely used as a medicinal material to protect the qi, such as a weak constitution with a lot of cold sweat. It is known to be very good for collapse (气血虛脫), prolapse (脫肛), cold sweat, and peripheral nerves.

Baekchul as used in the present invention refers to the rhizome of a plant, sapju or baekchul. Sapju is a perennial plant belonging to the Asteraceae family and grows to about 50 cm in height. It is distributed in Korea, Manchuria, and Japan. Underground stems are irregularly curved masses and are grayish-brown or brownish in color. The medicinal ingredients of baekchul include atractylol and atractylonen, and in animal experiments, they promote secretion of digestive enzymes, and have a continuous diuretic and sedative effect. In addition, it has a slight blood sugar lowering effect and has the effect of activating the function of the liver. In folklore, it is sometimes made into powder for indigestion.

Samchae (Allium hookeri) used in the present invention is a plant of the genus, and it grows wild in the grasslands of 1,400 ~ 4,000 meters above sea level in the Himalayas, and is distributed in China, India, Bhutan, Sri Lanka, and the like. The ancient Chinese have been using it for food and medicinal purposes since 3000 years ago. It is reported that plants of the genus Allium, such as green onion, garlic, and onion, which contain a large amount of sulfur compounds, have various physiological activities such as antioxidant, anti-cancer, anti-blood clotting, anti-cholesterol and hypoglycemic action.

The lactic acid bacteria (probiotics) used in the present invention are all living bacteria that have beneficial effects on health, and as it is known that intestinal bacteria play an important role in maintaining intestinal health and immunity to prevent various diseases, interest in probiotic health functional foods is increasing. have.

Probiotics are largely divided into bacillus and coccus according to their shape. A total of 19 probiotic strains have been recognized for their functionalities such as growth of beneficial bacteria, suppression of harmful bacteria, and improvement of bowel movements by the Ministry of Food and Drug Safety. 11 species of Lactobacillus, 4 species of Bifidobacterium (or Bifidobacterium), 1 species of Lactococcus, 2 species of Enterococcus, 1 species of Streptococcus, and the like.

Lactobacillus rhamnosus has high intestinal fixability and is stable against changes in acidity. Lactobacillus rhamnosus GG (LGG) strain is the most used in the study of the efficacy of probiotics. More than 800 articles published in scientific journals around the world have been covered in more than 200 clinical trials.

Lactobacillus vulgaris does not settle in the intestine but passes through it. Ilya Mechnikov, a professor at the Pasteur Institute in France, named yogurt containing this lactic acid bacterium as the secret to Bulgarian longevity. It has similar characteristics to Lactobacillus casei.

Lactobacillus casei was first isolated from cheese. Casei means cheese.

Lactobacillus plantarum leads the lactic acid fermentation of kimchi. It has a strong antioxidant effect, and helps to remove cold gut gas from irritable bowel syndrome (IBS). As a result of the experiment, it was confirmed that the level of brain-derived neurotrophic factor was increased to alleviate depression.

Lactobacillus acidophilus grows well in acid with a pH of 5 or less. It is used to treat ulcerative colitis and has excellent ability to kill Staphylococcus aureus.

Lactobacillus reuteri shortens the treatment period for diarrhea caused by rotavirus infection in infants and children, and suppresses Helicobacter pylori infection. It is effective in inhibiting the growth of Streptococcus mutans, which causes tooth decay.

Lactobacillus Fermentum absorbed cholesterol and lowered lipid levels in cell experiments.

Lactobacillus salivarius inhibits the growth of E. coli, which causes diarrhea, and Salmonella, which causes food poisoning.

Lactobacillus gasseri alleviated allergic diseases by lowering the level of immunoglobulin E (IgE) in the blood in a small clinical trial.

After debate, Lactobacillus helveticus was confirmed to have no blood pressure lowering effect.

Lactobacillus paracasei relieves allergic rhinitis and inhibits the proliferation of Salmonella and Helicobacter pylori.

Bifidobacterium bifidum prevents acute diarrhea and E. coli infection, and maintains vaginal homeostasis.

Bifidobacterium bribe is not motile and is used to treat ulcerative colitis.

Bifidobacterium longum has a ciliary structure and is strongly electrostatically attached to the wall of the endothelial cells of the small intestine.

Bifidobacterium animalis is helpful in the treatment of irritable bowel syndrome.

Lactococcus lactis inhibits the motility of the pathogen flagellum. As a result of an experiment by a Chinese research team inserting the KiSS-1 gene, a carcinogenic suppressor, into this lactic acid bacterium, it was confirmed that it prevents colon cancer metastasis.

Enterococcus faecium is symbiotic in the intestines of animals, but it can also cause neonatal meningitis and endocarditis. It is one of the common bacteria that is resistant to two or more antibiotics, that is, multidrug resistance.

Enterococcus fagalis can cause urinary tract infections, meningitis, etc., and can also cause antibiotic resistance. It has excellent viability even in extreme environments such as base (PH9.6). It survives at 60°C for 30 minutes.

Streptococcus thermophilus is resistant to heat and grows well at 35~42℃, and it is abundantly contained in dairy products. Because it breaks down lactose, it helps lactose intolerant patients to consume milk without an upset stomach.

According to one embodiment of the present invention, one or more of the 19 types of lactic acid bacteria may be mixed and used.

Moringa (Moringa oleifera) used in the present invention is a leguminous plant that is native to northern India and grows wild in tropical and subtropical regions, and contains a large amount of amino acids, minerals, vitamins, etc. Vitamin B2 30 times that of almonds, potassium 15 times that of bananas, iron 25 times that of spinach, vitamin A 10 times that of carrots, calcium 17 times that of milk, and protein 9 times that of yogurt. is known

Moringa is a tropical tree that eats the whole tree as well as leaves and fruits. (1) cholesterol prevention, (2) anti-inflammatory action, (3) vision improvement, (4) energy increase, (5) blood pressure normalization, (6 ) Restoring Skin Health, (7) Improving Digestive Function, (8) Strengthening Immune System, (9) Anti-wrinkle & Aging, (10) Improving Wound Healing, (11) Tumor Prevention, (12) Normalizing Blood Sugar, (13) Ulcer It is said to be the best source of natural antioxidants and to treat 300 diseases, as it is a natural source of more than 46 antioxidants and more than 36 anti-inflammatory compounds.

According to one embodiment of the present invention, seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder are used as active ingredients, preferably Based on 100 parts by weight of seaweed calcium, 12 to 18 parts by weight of galangal extract powder, 20 to 25 parts by weight of red ginseng concentrated powder, 12 to 18 parts by weight of astragalus extract powder, 5 to 8 parts by weight of baekchul extract powder, 2-3 parts by weight of ginseng extract powder A mixture mixed in an amount of 2 to 3 parts by weight of lactic acid bacteria and 2 to 3 parts by weight of Moringa extract powder is used as an active ingredient.

As used herein, the term "active ingredient" refers to a component capable of exhibiting the desired activity by itself or in combination with a carrier having no activity by itself.

In the food composition of the present invention, in addition to the seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder, vitamin B1 hydrochloride, vitamin E, vitamin D, fructose Oligosaccharides, silicon dioxide, colostrum protein, etc. may be additionally added.

According to a specific example of the present invention, the composition of the present invention may be for improving blood circulation, and may be a pharmaceutical composition effective for preventing, alleviating or treating vascular diseases. The composition according to the present invention is recognized for the efficacy of preventing thrombus formation, inhibiting vasoconstriction and/or inhibiting cholesterol. Specifically, the composition may be for improving blood circulation due to antithrombotic effect, and may be a food composition effective for prevention, alleviation or treatment of vascular diseases including obesity, diabetes and hyperlipidemia.

The composition according to the present invention inhibits platelet aggregation to inhibit thrombosis, inhibits increase in cholesterol, reduces blood and liver lipids, and is effective in improving blood circulation, obesity, diabetes, stroke, cerebral hemorrhage, arteriosclerosis, hypertension, It can be effectively used to prevent vascular diseases such as anemia, migraine or hyperlipidemia.

According to a specific example of the present invention, the composition of the present invention has an effect of preventing drowsiness, improving fatigue, improving digestive function and preventing obesity.

The composition of the present invention may contain the active ingredient in an amount of 0.01 to 90% by weight, more preferably 0.1 to 90% by weight, and still more preferably 10 to 80% by weight based on the total weight of the composition. At this time, if the content of the natural extract is less than 0.01% by weight, the anti-inflammatory effect, which is the objective effect of the present invention, cannot be obtained. There is a problem in that the stability of the shape is not secured.

In one embodiment of the present invention, the food composition may be a tablet, capsule, powder, granule, liquid, pill, liquid, syrup, juice, suspension, emulsion, or drop. For formulation, for example, in the form of tablets or capsules, the active ingredient may be combined with an orally, non-toxic, acceptable inert carrier such as ethanol, glycerol, water, and the like. In addition, if desired or required, suitable binders, lubricants, disintegrants and color-developers may also be included in the mixture. Suitable binders include, but are not limited to, starch, gelatin, natural sugars such as glucose or beta-lactose, corn sweeteners, natural and synthetic gums such as acacia, tracacanth or sodium oleate, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride, and the like. Disintegrants include, but are not limited to, starch, methyl cellulose, agar, bentonite, xanthan gum, and the like. In the composition formulated as a liquid solution, acceptable pharmaceutical carriers are sterile and biocompatible, and include saline, sterile water, Ringer's solution, buffered saline, albumin injection, dextrose solution, maltodextrin solution, glycerol, ethanol and One or more of these components may be mixed and used, and other conventional additives such as antioxidants, buffers, and bacteriostats may be added as needed. In addition, diluents, dispersants, surfactants, binders and lubricants may be additionally added to form an injectable formulation such as an aqueous solution, suspension, emulsion, etc., pills, capsules, granules or tablets.

In addition, the food composition of the present invention may be used as a functional food or added to various foods. Foods to which the composition of the present invention can be added include, for example, tea, beverages, meat, chocolate, jelly, foods, confectionery, pizza, ramen, other noodles, gums, candies, ice cream, alcoholic beverages, vitamin complexes and There are health supplements, etc.

In addition, the food composition includes various nutrients, vitamins, minerals (electrolytes), synthetic flavoring agents and natural flavoring agents in addition to the active ingredients, coloring agents and thickeners (cheese, chocolate, etc.), pectic acid and salts thereof, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like.

In addition, the present invention provides a health functional food comprising seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder as active ingredients.

The health functional food of the present invention can be manufactured and processed in the form of tablets, capsules, powders, granules, liquids, pills, and the like.

In the present invention, the term "health functional food" refers to a food manufactured and processed using raw materials or ingredients useful for the human body in accordance with the Health Functional Food Act, and controls nutrients or physiological functions for the structure and function of the human body. It means taking for the purpose of obtaining useful effects for health purposes, such as action.

The health functional food of the present invention may include normal food additives, and unless otherwise specified, whether it is suitable as a food additive is related to the item according to the general rules and general test method of food additives approved by the Food and Drug Administration. It is judged according to the standards and standards.

The items listed in the Food Additives Codex include, for example, chemical compounds such as ketones, glycine, calcium citrate, nicotinic acid, and cinnamic acid; natural additives such as persimmon pigment, licorice extract, crystalline cellulose, high pigment, and guar gum; and mixed preparations such as sodium L-glutamate preparations, noodles-added alkalis, preservatives, and tar dye preparations.

For example, health functional food in tablet form contains seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder as excipients, binders, disintegrants and other The mixture mixed with the additive may be granulated in a conventional manner, and then a lubricant may be added and compression-molded, or the mixture may be directly compression-molded. In addition, the health functional food in the form of tablets may contain a corrosive agent and the like, if necessary.

Among health functional foods in the form of capsules, hard capsules contain seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract, which are the active ingredients of the present invention in common hard capsules. It can be prepared by filling a mixture of powder with additives such as excipients, and soft capsules can be prepared by filling a mixture of the extract with additives such as excipients in a capsule base such as gelatin. The soft capsules may contain a plasticizer such as glycerin or sorbitol, a colorant, a preservative, and the like, if necessary.

The health functional food in the form of a pill is an active ingredient of the present invention, such as seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder and excipients, binders, and disintegrants. It can be prepared by molding a mixture mixed with the above, etc. by a known method, and can be coated with sucrose or other skinning agent if necessary, or the surface can be coated with a material such as starch or talc.

The health functional food in the form of granules is the active ingredient of the present invention: seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder and excipients, binders, disintegrants The mixture in which the etc. are mixed may be prepared in a granular form by a conventionally known method, and if necessary, a flavoring agent, a flavoring agent, etc. may be contained.

According to one embodiment of the present invention, there is provided a jelly composition comprising the food composition according to the present invention.

The jelly composition can be prepared by mixing the food composition according to the present invention and a sweetener, acidity regulator, flavoring agent, tissue improver, preservative, etc. together, and the formulation of the additive can be adjusted to control the strength, texture, etc. of the jelly. have.

Hereinafter, examples and the like will be described in detail to help the understanding of the present invention. However, the embodiments according to the present invention may be modified in various other forms, and the scope of the present invention should not be construed as being limited to the following examples. The embodiments of the present invention are provided to more completely explain the present invention to those of ordinary skill in the art.

<Preparation Example 1> Preparation of food composition containing seaweed calcium, galangal extract powder, red ginseng concentrate powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder

A food composition containing seaweed calcium, galangal extract powder, red ginseng concentrated powder, astragalus extract powder, baekchul extract powder, ginseng extract powder, lactic acid bacteria and moringa extract powder was prepared with the composition shown in Table 1 below.

ingredient weight% Vitamin B1 Hydrochloride 0.03 vitamin E 0.60 vitamin D3 0.09 seaweed calcium 33.00 Galangal Extract Powder 4.20 Red Ginseng Concentrated Powder 7.00 Astragalus Extract Powder 5.00 baekchul extract powder 2.00 fructooligosaccharide 38.28 silicon dioxide 1.20 Plant Mixed Extract HMS 5.00 Three vegetable extract powder 0.80 Lactobacillus 0.80 Moringa Extract Powder 0.80 colostrum protein 1.20

<Test Example 1> Measurement of blood vessel relaxation effect

In order to confirm the blood vessel relaxation effect of the composition prepared in Example 1, the coronary artery relaxation effect of the pig heart was measured.

First, after purchasing a pig heart immediately after slaughter from a slaughterhouse, a coronary artery was removed and 18 mM NaCl, 47 mM KCl, 11 mM MgSO ₄ , 12 mM KH ₂ PO4, 15 mM CaCl ₂ , 25 mM NaHCO ₃ , 10 mM glucose was placed in a Krebs solution (pH 7.4) containing

Then, the coronary artery _{was fixed in a Krebs solution at 37° C. saturated with 95% O 2} and 5% CO ₂ gas, and then treated with U46619 (1-60 nM), a thromboxane derivative, for 10 minutes at 80% of vasoconstriction. contracted while Then, the stability of the vascular endothelial cells was measured by a relaxation reaction with 300 nM Bradykinin, and then washed three times with Krebs solution.

Then, after constriction with U45519 in the coronary artery whose stability was measured, the composition prepared in Example 1 was treated at a concentration of 100 μg/ml to obtain isometric tension by force-displacement transducer (HugoSachs). , Germany) equipped with a physiological recorder (Grass physiograph, HugoSachs, Germany) was used to measure the change in the vasodilation effect.

As a control group, a ginkgo leaf extract used as a conventional vasoprotectant was used. Measurement of changes in vasodilation effect was measured three times for each sample and expressed as the average and standard deviation, and the ED50 value means the concentration (㎍/ml) of the sample in which the constricted blood vessels exhibit 50% vascular relaxation by sample treatment. do. The results are shown in Table 2.

ED50 (μg/ml) Control (Ginkgo Leaf Extract) 291 Composition of Example 1 6.1

As shown in Table 2, the composition of Example 1 exhibited a vasodilatory effect of about 50 times that of the control (ginkgo leaf extract), confirming the high blood and relaxation efficacy of the composition according to the present invention.

<Test Example 2> Evaluation of T-lymphocyte and B-lymphocyte proliferative capacity in the mouse spleen

The effect of the composition of Example 1 of the present invention on the proliferation of T-lymphocytes and B-lymphocytes, which are immune cells in the spleen, was investigated.

As the experimental animals, 7-week-old female C57BL/6 mice (Orient Bio, Gapyeong-gun, Gyeonggi-do, Korea) were used, and a total of 42 mice, 6 in each test group, were used. The purchased animals were used for the test after an adaptation period for one week in a laboratory with a temperature of 21±3℃, a relative humidity of 50±5%, and an illumination of 200-300 Lux. No weight change or adverse reactions were observed. All samples were suspended using physiological saline (Chungwae Pharmaceutical, Korea), and the samples were orally administered at 100 mg/kg once a day for a total of 7 days. The normal control group was administered the same amount of physiological saline in the same way. Splenocytes were isolated from the spleen from the experimental animals after administration, and then the cells were inoculated in a ^{96-well plate at 5×10 5 cells/well.} Thereafter, a concanavalin A (Con A; Sigma Aldrich, St. Louis, MO, USA) solution at a concentration of 5 μg/ml was added to each well for T-lymphocyte proliferation measurement, and 15 μg/ml concentration for B-lymphocyte proliferation measurement. of LPS (Sigma Aldrich, St. Louis, MO, USA) solution was added by 10 μl each and reacted at 37° C., 5% CO 2 in an incubator for 72 hours. After the reaction was completed, 20 μl of cell titer solution (Promega, USA) was added to the cell culture medium and incubated for 4 hours, followed by fluorescence Multi-Detection Reader ((BIO-TEK Instruments Inc., Power wave X340, Winooski, VT, USA). ) was used to measure the absorbance at 490 nm.

As a result, as shown in Table 3 below, it was confirmed that the degree of proliferation of T-lymphocytes and B-lymphocytes was increased in both groups administered with the composition of Example 1 of the present invention.

control composition T lymphocytes 14 54 B lymphocytes 8 55

<Test Example 3> Immune function enhancement activity test

RAW 264.7 cells, which are mouse macrophages purchased from the Korea Cell Line Bank, were cultured at _{37° C. and 5% CO 2 .} Cell culture was performed in RPMI 1640 medium with sodium bicarbonate (NaHCO ₃ , 2 μg/l), antibiotics (10,000 units/ml penicillin G sodium, 10,000 units/ml streptomycin sulfate, 25 μl/ml amphotericin B), 2-ME (2- mercaptoethanol, 50 μM) and 10% FBS (fetal bovine serum) were used.

RAW 264.7 macrophages were aliquoted in a 96-well plate at ^{a cell number of 5 × 10 4} cells/well, cultured for 18 hours, and then treated with LPS (1 μg/ml) to induce activation. Then, the composition of Example 1 was treated at a concentration of 0.05 mg/ml and cultured for 24 hours, and the degree of nitric oxide production in the cell culture was evaluated by measuring the absorbance at 540 nm using an ELISA reader. The results were compared with the sample untreated group (LPS only treatment group), and the degree of promotion of NO production was expressed as a percentage.

As a result, it can be seen that the NO production promoting activity (%) is 134.5±3.9%, indicating that the composition sample promotes NO production.

<Test Example 4> Drowsiness prevention effect evaluation

Male bus drivers (45 people, 30 to 62 years old) and male and female high school students (45 people, male to female ratio 30:30, 16 to 18 years old) were targeted, and after ingesting the composition of Example 1, while driving or learning The purpose of this study was to evaluate the degree of help in preventing drowsiness.

For evaluation, each of the two groups of male bus drivers (n = 5) and two groups of male and female high school students (n = 5) were divided into two groups (n = 5) and each composition of Example 1 was given to the participants between 1 and 2 pm after lunch. After giving and eating within 1 minute, the degree of help in preventing drowsiness during work hours is measured on the same night by the 5-point scoring method in Table 4 below (5 points: very good, 4 points: excellent, 3 points: average, 2 Point: bad, 1 point: very bad).

anti-drowsiness effect Example 1 4.5±2.1 Red Ginseng Jelly 1.4±2.0

As shown in Table 4, in the case of male drivers and high school students taking the composition of Example 1, the effect of preventing drowsiness was very good. On the other hand, in the case of the existing red ginseng jelly, the effect of preventing drowsiness tended to be somewhat lower.

<Test Example 5> Fatigue recovery improvement effect confirmed

The composition of Example 1 was administered to 20 men and women of all ages in their 10s and 40s for 30 days, 110 ml 3 times a day for 2 hours after lunch, and after taking 30 days, improved digestion, improved fatigue and The degree of skin improvement was shown in Table 5 below by a 5-point scoring method (5 points: very good, 4 points: excellent, 3 points: average, 2 points: poor, 1 point: very poor). For this purpose, the effect of improving the digestive function, the effect of improving the feeling of lethargy, the effect of improving the overall feeling of fatigue, etc. were confirmed. For comparison, red ginseng jelly was used.

digestive function
improvement effect lethargy
improvement effect fatigue
improvement effect Example 1 4.8 4.4 4.3 Red Ginseng Jelly 2.5 2.4 2.3

As shown in Table 5, the composition of the present invention has a very good digestive function improvement effect, has an effect of reducing lethargy, and improved overall fatigue. Especially, when it was consumed after lunch, it was evaluated that the digestive function was rather improved, and the fatigue was improved, so that it was possible to concentrate more on studying or work in the afternoon.

<Test Example 6> Weight and blood cholesterol reduction experiment

Using ICR mice as experimental animals, the test control group and the normal group using the composition of Example 1 as a material were fed with food and breeding was compared.

In this experiment, the basic diet was AIN-76, the protein source was casein (Japan), the carbohydrate source was corn starch (cheiljedang), and the normal group and the test control group were compared with the test control group using corn oil (subject) as the fat source. proceeded. The food composition used in this experiment was orally fed by 1 ml at a certain time every day, and food and drinking water were arbitrarily ingested. The breeding environment for test animals was constant temperature (20±2℃), constant humidity (50±5%), and maintaining constant conditions with a 12-hour photoperiod, two animals were separately bred in polycarbonate cages. In animals, cholesterol circulates through the bloodstream and is synthesized by several organs. If the cholesterol level in the bloodstream is high, it is the main cause of arteriosclerosis. Therefore, the analysis items are (1) weight change and dietary intake, (2) blood cholesterol and triglyceride measurement proceeded to do.

After breeding, the animals were fasted for 12 hours, anesthetized by inhaling ether, and then blood was collected from the inferior vena cava, treated with heparin and plasma separated by centrifugation (15 mins, 3,000 RPM) to measure the lipid content. did.

The intestines (liver, epididymis, kidney) of each experimental animal were immediately extracted after blood collection, rinsed several times with PBS (Phosphate Buffered saline) solution, and then surface moisture was removed for comparative quantification. For plasma triglycerides, absorbance was measured at 550 nm using a color-generating triglyceride measurement solution (Asan kit) using the enzymatic method of McGowan et al. (1983). The total cholesterol measurement solution (Asan kit) was used for color development, and the absorbance was measured at 500 nm and quantified by comparison with the standard cholesterol curve. ml, Chloroform: Methyl alcohol 2:1 solution was extracted, and triglycerides and cholesterol were quantified in the same way as in plasma. Each item was statistically processed and averaged.

(1) Weight change

Changes in body weight and dietary intake of the experimental animals are shown in Tables 6 and 7, respectively.

Referring to Table 6 below, in the case of the experimental animals orally fed the composition prepared in Example 1, the body weight was similar or decreased compared to before the experiment, whereas in the case of the experimental animals and the normal group fed orally with a general diet compared to before the experiment, You can see that the weight has increased.

Referring to Table 7 below, it was confirmed that the dietary intake of the experimental animals and the normal group orally fed the composition prepared in Example 1 and the general diet were all similar.

Before experiment (g) After experiment (g) Example 1 27.53 25.05 general diet 27.21 28.31

Dietary intake (g) Example 1 4.0 general diet 4.1

Through this, although the dietary intake of all the experimental animals was similar, the weight of the experimental animals that consumed the composition of Example 1 did not increase, and it was confirmed that it could be used as a diet food because it was similar to before the experiment or decreased compared to before the experiment.

(2) blood cholesterol and triglycerides

Plasma triglycerides, plasma cholesterol, epididymal triglycerides, triglycerides in kidney tissue, and cholesterol in liver tissue of experimental animals are shown in Tables 8 and 9 below.

Referring to Table 8 below, the test control group ingesting the composition of Example 1 significantly reduced plasma triglycerides compared to before the experiment, whereas the test control group ingesting the general diet showed no significant change.

Before experiment (mg/dL) After experiment (mg/dL) Example 1 121 118 general diet 120 131

Referring to Table 9 below, it can be seen that the test control group ingesting the food composition of Example 1 significantly reduced plasma cholesterol compared to before the experiment, whereas the general diet did not show any significant change.

Before experiment (mg/dL) After experiment (mg/dL) Example 1 156 118 general diet 157 152

Through the above results, the composition prepared in Example 1 according to the present invention can confirm the decrease in the amount of triglycerides, it was confirmed that the characteristics of improving fat and cholesterol.

<Test Example 7> Sensory test

In order to evaluate the sensory properties of the food composition of the present invention, a sensory test was performed comparing jelly and red ginseng jelly using the food composition prepared in Example 1.

The sensory tests for scent, taste, color, texture, and overall preference were repeated three times for 20 sensory test agents, and the results shown in Table 10 below were obtained.

As the test method, a 5-point comparative scale method was used. Scores of 5 points for very good, 4 points for good, 3 points for average, 2 points for dislike, and 1 points for dislike were given, respectively, and the final response scores were added together. The arithmetic mean value was calculated.

division Example 1 Red Ginseng Jelly incense 4.3 3.3 taste 4.4 3.1 color 4.2 3.0 texture 4.4 3.2 overall sign 4.4 3.1

As a result of the experiment, the flavor, taste, color, and texture of the jelly according to the present invention were very high, giving an overall preference of 4.4, while the overall preference of the red ginseng jelly was very low at 3.1, respectively.

Claims (6)

Based on 100 parts by weight of seaweed calcium, 12 to 18 parts by weight of galangal extract powder, 20 to 25 parts by weight of red ginseng concentrated powder, 12 to 18 parts by weight of astragalus extract powder, 5 to 8 parts by weight of baekchul extract powder, 2-3 parts by weight of extract powder Food composition, characterized in that it is mixed in an amount of 2 to 3 parts by weight of lactic acid bacteria and 2 to 3 parts by weight of Moringa extract powder by weight. delete The method of claim 1,
Food composition, characterized in that vitamin B1 hydrochloride, vitamin E, vitamin D, fructooligosaccharide, silicon dioxide and colostrum protein are additionally added. delete delete 4. The method of claim 1 or 3,
Food composition, characterized in that the composition is in the form of a jelly.