CN103918793B - A kind of stomach strengthening and digestion promoting probio goat milk sheet and preparation method thereof - Google Patents

A kind of stomach strengthening and digestion promoting probio goat milk sheet and preparation method thereof Download PDF

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CN103918793B
CN103918793B CN201410142871.7A CN201410142871A CN103918793B CN 103918793 B CN103918793 B CN 103918793B CN 201410142871 A CN201410142871 A CN 201410142871A CN 103918793 B CN103918793 B CN 103918793B
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probio
goat milk
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powder
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CN103918793A (en
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陈合
张建华
舒国伟
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Shaanxi British children's Dairy Co., Ltd.
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Shaanxi University of Science and Technology
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Abstract

The invention discloses a kind of stomach strengthening and digestion promoting probio goat milk sheet and preparation method thereof, mass percent comprises the goat milk powder of 53.5%-80.2%, the mixture A of 10%-30%, 0.1%-1% freeze-drying probiotics bacterial powder, 5%-7% sucrose, 0.5%-1.0% synanthrin, 4%-7% glucose and 0.2%-0.5% microcrystalline cellulose; Described mixture A is mixed to get by the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and the hawthorn mass ratio by 1:1:2:2.The present invention adds the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis, hawthorn in goat milk, and these integration of drinking and medicinal herbs materials and probio are pressed into tablet, both tool each composition stomach strengthening and digestion promoting effect, can effectively improve enteral nutrition and colony balance again.The EGF contained in goat milk, while promotion epithelial cell growth, also has repair to mucomembranous epithelial cells such as stomach, tracheae and skins, nutritious, is convenient for carrying again and eats.

Description

A kind of stomach strengthening and digestion promoting probio goat milk sheet and preparation method thereof
Technical field
The invention belongs to field of health care food, relate to a kind of stomach strengthening and digestion promoting probio goat milk sheet and preparation method thereof.
Background technology
Goat milk, with the health idea of high nutrition, high-quality, has come into the sight line of consumer with striding greatly, meets national consumption hobby and nutritional need, becomes the another high consumption focus outside milk.Especially the high-quality goat milk produced of Shaanxi, receive the height accreditation of domestic market especially, and increasing goat milk brand starts to go abroad, and explores overseas market actively, fully demonstrates the potentiality that should not be underestimated in goat milk market.
Goat Milk has been widely regarded as the food being particularly suitable for the elderly, sick people, sick convalescent people and infant and using.Goat milk is existing has many advantages for milk: 1. Goat Milk Medium chain fatty acid content is high, and wherein aliphatic acid is divided into three kinds, long, medium and short chain.Medium chain and SCFA easier than long-chain be subject to body fat enzyme attack and digested absorption.In addition, medium chain fatty acid has unique mechanism of absorption, and directly can be absorbed at small intestine without the digestion of pancreas enzyme and cholate, the content of Goat Milk medium chain fatty acid is the twice of milk.2. Goat Milk fat globule diameter is little.The diameter of fat globule is less, just has larger surface area to attack for the lipase of human intestine, makes fat be decomposed faster.In general, the digestion of Goat Milk faster than milk 20%.Although the diameter of milk and Goat Milk fat globule separately has difference, on average, the diameter of Goat Milk fat globule is more much smaller than milk.On general, the diameter of Goat Milk fat globule is 2-2.5 micron, and milk is 3-4.25 micron.The digestion process of little, the frangible protein of curd firmness in human body that Goat Milk is formed first under hydrochloric acid in gastric juice effect, forms curdled milk, and the digestion that is then decomposed, for amino acid, is absorbed at small intestine afterwards.The soft durometer of ziega directly affects the digested speed of protein and efficiency.Protein main in Goat Milk is beta-casein, has structural difference with protein alpha-S1 casein main in milk.The ziega that Goat Milk beta-casein is formed under one's belt has been proved to be more soft than milk frangible.3. strengthen the absorption of iron and calcium.Iron in milk and calcium, owing to there being interaction, can have influence on the absorption of wherein a kind of element.And iron in Goat Milk and calcium do not have this interaction, therefore bioavilability is higher than milk.
Probio (Probiotics), also known as probiotic, regulator, raw rhzomorph, viable bacteria element etc., namely certain microorganism formulation or fermented product is referred to, by regulating host's mucous membrane and systemic immune function and improving enteral nutrition and colony balance, useful physiological action is produced to host, changed the composition of host a certain position flora by colonized action, thus generation is conducive to the single of host health effect or forms clear and definite mixed microorganism.Up to now, the probio that scientist has found can be divided into three major types substantially, comprising: 1. lactobacillus class (as lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, lactobacillus plantarum etc.); 2. Bifidobacterium class (as bifidobacterium longum, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis etc.); 3. gram-positive cocci (as streptococcus fecalis, galactococcus, intermediary streptococcus etc.).Probio is as a frontier, and in recent years, the special physiological activity of probio is widely used in food, except being applied to fermented dairy product, is also just progressively applied to developing various functional food.At present, probio is mainly used in the fields such as food, functional food, dietary supplements, medicinal organism goods and feed.Food containing profitable probliotics is referred to as probiotic food, mainly comprises and directly add the food of probio and the food through probiotics fermention.The application the most general in field of food of probio is still dairy products field, comprises acidified milk, active lactic acid bacteria drink, cheese, sour cream, kefyr, fruit juice, cereal preparation, biscuit etc.Probio bacterial classification have Bifidobacterium (Bifidobateria), Bacillus acidi lactici and some streptococcus, wherein, what Bacillus acidi lactici was conventional has lactobacillus acidophilus (Lactobicullusacidophilus), Lactobacillus casei (L.casei), lactobacillus bulgaricus (L.bulgaricus) etc.The probio bacterial classification that can be used for health food of the Ministry of Public Health of current China approval has: lactobacillus acidophilus, Lactobacillus casei, lactobacillus reuteri, Lactobacillus rhamnosus, bifidobacterium bifidum, bifidobacterium infantis, bifidobacterium breve, bifidobacterium longum, blue and green Bifidobacterium, lactobacillus bulgaricus, streptococcus thermophilus etc.
Radix Codonopsis calls Shangdang ginseng, Huang Can, platform Radix Codonopsis, upper Radix Codonopsis.In being born in mountain region bushes and border.Main product in Shanxi, Shaanxi, Gansu, province and the various places, northeast such as Sichuan.Radix Codonopsis is perennial herb, root elongated cylindrical, and there is the root head expanded on top, and crust milk yellow, to light taupe brown, has wrinkle in length and breadth.Radix Codonopsis, mainly containing compound and some other micro constitutents such as polysaccharide, alcohol glycoside, Phenylpropanoid Glycosides glycoside, alkaloids, has higher medicine-food two-purpose to be worth.Radix Codonopsis can correct the gastrointestinal motility dysfunction of pathological state, preventive and therapeutic action is had to stress ulcer with the neutral extract of the n-butanol of Radix Codonopsis, have tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung, has wide practical use in food, medical industry simultaneously.
Hawthorn has another name called large-fruited Chinese hawthorn, is the ripening fruits of rose family machaka or dungarunga fructus crataegi cuneatae or hawthorn.Stone fruit, caryoplasm is hard, and pulp is thin, and taste is micro-sour and astringent.In Heilungkiang, Jilin, Liaoning, the ground such as Inner Mongol, oral hawthorn can promote the secretion of enzyme in stomach, and promote digestion, contained lipase also can help liposuction and digestion, and fruit is raw-eaten or make jam fruitcake; Being used as medicine after drying, having that stomach invigorating, long-pendingization that disappear are stagnant, the effect of the loose stasis of blood of having a respite, is Chinese distinctive medicine fruit dual-purpose seeds.Gather during time of the year when autumn changes into winter fruit maturation.Dry, life is used or is fried and uses.
The bighead atractylodes rhizome is called in art, winter art, in the latent bighead atractylodes rhizome, is the rhizome of the feverfew bighead atractylodes rhizome.Main product in Zhejiang, Anhui, Hubei, Hunan, the province such as Jiangxi.The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.Effect: strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Can be used for insufficiency of the spleen food few, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.
The purple Piao of bark of official magnolia another name, purple oil Piao, Wen Piao etc. are the dry dry hide of Magnoliaceae, the magnolia bark of official magnolia or Magnolia bilola, Gen Pi and branch skin.This medicinal material is warm in nature, bitter, fortunately.Have therapeutic action to diseases such as stagnation of QI due to dyspepsia, abdominal distention constipation, damp retention in middle-jiaos, have eliminating dampness loose full, help digestion loose ruffian, effect of depressing Qi and relieving asthma simultaneously.
Microcrystalline cellulose is the cellulose of a kind of purifying, part depolymerization, white, odorless, tasteless, the crystalline powder be made up of small porous particle.Be widely used in the industries such as pharmacy, cosmetics, food, not only can be used for wet granulation and also can be used for dry method direct tablet compressing.As disintegrant and adhesive, these two kinds of effects can be integrated, effectively prevent multiple additives and use the harmful effect caused simultaneously in tablet preparation.
In recent years, the research great majority of hawthorn and Radix Codonopsis are for health protection tea, drinks etc., patent (CN103494135A) discloses the preparation method of Rubussuavissmuscratasliceinnatifida sliceinnatifida, patent (CN103504054A) discloses the preparation method that Radix Codonopsis protects heart tea, and patent (CN103509685A) discloses the preparation method that Radix Codonopsis protects heart wine; Slightly report in medical, patent (CN102793896A) discloses a kind of preparation method of Radix Astragali Radix Codonopsis sheet, to the series products specially controlling alpastic anemia.But for the bark of official magnolia and the bighead atractylodes rhizome except in health protection tea relevant report a lot of except, be applied in pharmaceuticals industry and tablet and slightly relate to, patent (CN103536666A) discloses a kind of bighead atractylodes rhizome Chinese medicine preparation, and patent (CN102847046A) discloses the preparation method of the real spleen sheet of one group of bark of official magnolia bighead atractylodes rhizome.But the report bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are applied in tablet as the prebiotic factor is very few, and application microcrystalline cellulose is also less as the relevant report of adhesive and this double-deck role of disintegrant, goat milk has again many advantages compared with milk simultaneously.Therefore in goat milk sheet, with the addition of probio can effectively improve enteral nutrition and colony balance with the material being beneficial to stomach strengthening and digestion promoting, promote the absorption of food digestion and nutriment, make human body become more healthy and dynamic.
Summary of the invention
For above-mentioned defect or deficiency, the object of the present invention is to provide a kind of stomach strengthening and digestion promoting probio goat milk sheet and preparation method thereof.
For reaching above object, technical scheme of the present invention is:
A kind of stomach strengthening and digestion promoting probio goat milk sheet, comprise the goat milk powder of 53.5%-80.2% by mass percentage, the microcrystalline cellulose of the freeze-drying probiotics bacterial powder of the mixture A of 10%-30%, 0.1%-1%, the sucrose of 5%-7%, the synanthrin of 0.5%-1.0%, the glucose of 4%-7% and 0.2%-0.5%;
Described mixture A is mixed to get by the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and the hawthorn mass ratio by 1:1:2:2.
Described freeze-drying probiotics bacterial powder is the mixture of probio and compound freeze drying protectant;
Wherein probio mixes according to the ratio of every g probio with the compound freeze drying protectant of 1mL with compound freeze drying protectant;
Wherein probio adopts viable count to be (1.0-3.0) × 10 11lactobacillus acidophilus bacterium powder, viable count be (1.0-3.0) × 10 11the Mixed Microbes of these two kinds of arbitrary proportions of bifidobacterium bifidum bacterium powder;
Compound freeze drying protectant comprises and comprising by mass percentage: the skimmed milk power of 18%-50%, the trehalose of 8%-20%, the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% phosphate buffer.
A preparation method for stomach strengthening and digestion promoting probio goat milk sheet, comprises the following steps:
1) constant weight is dried to after fresh hawthorn being cleaned peeling;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn is Powdered by being ground into after the mass ratio mixing of 1:1:2:2, then cross 40-80 object sieve and obtain mixture A;
3) get the probio after activation with 2 ~ 5% the fermentation tank culture 18h of inoculum concentration access 10LMRS culture medium, stir once every 3-4h in incubation, rotating speed 60 turns/min, mixing time 2min, then, probiotics bacterial mud is made with the centrifugal 12min of the rotating speed of 10000 turns/min with centrifuge, then in probiotics bacterial mud, the compound freeze drying protectant of 1mL is added by every g probio mud, vortex mixed instrument is utilized to be mixed even, at-40 ~-20 DEG C of pre-freeze 12 ~ 24h, then move to freeze drier freeze drying 24h acquisition freeze-drying probiotics bacterial powder;
Described compound freeze drying protectant comprises: be made up of the phosphate buffer of the trehalose of the skimmed milk power of 18%-50%, 8%-20%, the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% by mass percentage;
4) by sheep breast after purification and standardization, reduced pressure concentration makes solid content reach 42% ~ 50% and obtains raw material sheep breast, crosses 40 ~ 80 mesh sieves by spraying dry and after cool to room temperature and obtains goat milk powder;
5) by mass percentage by the goat milk powder of 53.5%-80.2%, the mixture A of 10%-30%, the microcrystalline cellulose of the sucrose of 0.1%-1% freeze-drying probiotics bacterial powder, 5%-7%, the synanthrin of synanthrin 0.5%-1.0%, the glucose of 4%-7% and 0.2%-0.5% mixes, and obtains mixture B;
Then utilize tablet press machine, mixture B is made unit viable count and reaches (1.0-3.0) × 10 7~ (1.0-3.0) × 10 9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn compound probiotic of cfu/g.
The drying of described step 1) adopts blast drier 70 DEG C of dryings.
Described step 2) pulverize employing meet operative norm Q/12NK4558-2006, power of motor is 1200W, rotating speed be 2400r/min medicinal herb grinder pulverize.
Described probio is viable count is 1.0-3.0 × 10 11lactobacillus acidophilus bacterium powder, viable count be 1.0-3.0 × 10 11the mixing of these two kinds of arbitrary proportions of bifidobacterium bifidum bacterium powder.
The activation process of described probio is as follows:
Under 37 DEG C of condition of culture, adopted by lactobacillus acidophilus MRS fluid nutrient medium to activate three times, the cysteine hydrochloride that Bifidobacterium adds culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium to activate three times under 37 DEG C of condition of culture, transfer with the inoculum concentration of 2 ~ 5% at every turn, wherein all under 37 DEG C of condition of culture, cultivate 20-24h first twice, third time cultivates 18h under 37 DEG C of condition of culture, then carry out microscopy, survey OD value, determine without after miscellaneous bacteria, third time activation to be obtained activating probio.
Described spraying dry EAT is 160 ~ 165 DEG C, and temperature of outgoing air is 75 ~ 65 DEG C.
The mixing of described step 5) adopts rotating speed to be 5 ~ 20 turns/min, and power of motor is the three-dimensional motion mixer of 0.5Kw;
The maximum tableting pressure of described single-punching tablet press: 50KN; Pellet diameter: sheet is heavily 1.0 ~ 1.6g; Hardness is at 4 ~ 7N.
Compared with the prior art, beneficial effect of the present invention is:
1) in the present invention, main component is goat milk powder, because Goat Milk is rich in albumin, the contour quality protein of globulin and the aliphatic acid and several mineral materials played an important role to health, to nutrient absorption, bad syndrome patients has good health care and therapeutic action.Goat milk fat globule little (being only 1/3 of milk), and be rich in be beneficial to body directly utilize in, short chain unrighted acid, absorptivity is very high.The EGF(EGF contained in goat milk), while promotion epithelial cell growth, repair is had to mucomembranous epithelial cells such as stomach, tracheae and skins, can urge digestion again can tranquilizing and allaying excitement (because of containing cyclic nucleotide), and can immunity of organisms be strengthened, regulate human body nutrient balance, improve sleep quality, the comfort cushioning characteristic of its meta-alkalescence also has the effect promoting rehabilitation to diseases such as ephritis, tuberculosis and asthma, be the excellent health products of infant, pregnant woman, old man and patient.
2) with the addition of probio in the present invention, probio has obvious facilitation to health, science proves that it has following effect: 1, prevent and improve constipation, diarrhoea, safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, pass through bidirectional modulation, prevent constipation, diarrhoea, adjustment function of intestinal canal is disorderly, prevents various intestines problem.2, antitumor, from Bifidobacterium isolated antitumor polysaccharide class, enzyme is lost activity, thus the generation of pre-anti-cancer.3, control the cholesterol in serum, a large amount of clinical trial both at home and abroad confirm, take lactobacillary milk goods and have minimizing human serum cholesterol level, reduce effect of cardiovascular disease incidence rate.1997, Gimland proposed lactic acid bacteria promotes cholesterol catabolism by degraded cholate at first, thus reduces the viewpoint of cholesterol level.4, biological barrier effect, reduces the generation of harmful substance in harmful bacteria metabolin, forms the membranes barriers that one deck has protective effect, stops the invasion of pernicious bacteria, accelerate the discharge of various toxin in enteron aisle.Play the effect improving intestinal environment and protection enteron aisle.5, promote generation and the absorption of Parenteral Nutrition material, Bifidobacterium can self synthesis or promotion synthetic vitamin B 1, B 2, B 6, B 12and the nutriment of the needed by human such as amino acid, improve the absorption to calcium ion, realize stomach normalization.6, arrange stool, purify the blood fat, hypotensive, accelerates lipolysis, old loose fat in adsorbent, reduces serum cholesterol level.Thus certain prevention effect is had to hypertension and artery sclerosis.7, improve immunity, have and promote cytotostatic and increase intestine immunity enhanced feature, prevent antibiotic side effect, to trigger cell mutation factor, there is resistant function.Anti-ageing, promote longevity.8, lactose intolerance is improved, the ferment that Bifidobacterium reduces lactose, to help improve lactose intolerance.9, other functions, as food hypersenstivity, prevention diabetes etc.Exactly because probio is for effect of human health, it is received much concern.
3) with the addition of Radix Codonopsis in the present invention, mainly containing compound and some other micro constitutents such as polysaccharide, alcohol glycoside, Phenylpropanoid Glycosides glycoside, alkaloids, have higher medicine-food two-purpose to be worth.Radix Codonopsis can correct the gastrointestinal motility dysfunction of pathological state, preventive and therapeutic action is had to stress ulcer with the neutral extract of the n-butanol of Radix Codonopsis, have tonifying middle-Jiao and Qi, effect of invigorating the spleen benefit lung, has wide practical use in food, medical industry simultaneously.
4) with the addition of hawthorn in the present invention, can promote the secretion of enzyme in stomach, promote digestion, contained lipase also can help liposuction and digestion, and fruit is raw-eaten or make jam fruitcake; Being used as medicine after drying, having that stomach invigorating, long-pendingization that disappear are stagnant, the effect of the loose stasis of blood of having a respite, is Chinese distinctive medicine fruit dual-purpose seeds.
5) with the addition of the bighead atractylodes rhizome in the present invention, have multinomial medicinal efficacy: strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive, also can be used for insufficiency of the spleen food few, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.
6) with the addition of the bark of official magnolia in the present invention, this medicinal material is warm in nature, bitter, fortunately.Have therapeutic action to diseases such as stagnation of QI due to dyspepsia, abdominal distention constipation, damp retention in middle-jiaos, have eliminating dampness loose full, help digestion loose ruffian, effect of depressing Qi and relieving asthma simultaneously.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, and the explanation of the invention is not limited.
Embodiment 1:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; Be cut into small pieces after fresh hawthorn is cleaned peeling, then adopt blast drier to be dried to constant weight at 70 DEG C respectively;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are met operative norm Q/12NK4558-2006 by adopting after the mass ratio mixing of 1:1:2:2, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 40 object sieves and obtain mixture A;
3) first, under 37 DEG C of condition of culture, adopted by probio MRS fluid nutrient medium to activate obtain for three times activating probio, get the probio after activation with 2% the fermentation tank culture 18h of inoculum concentration access 10LMRS culture medium, stir once every 3h in incubation, rotating speed 60 turns/min, mixing time 2min, then, probiotics bacterial mud is made with the centrifugal 12min of the rotating speed of 10000 turns/min with centrifuge, then in probiotics bacterial mud, the compound freeze drying protectant of 1mL is added by every g probio mud, vortex mixed instrument is utilized to be mixed even, at-40 DEG C of pre-freeze 12h, move to freeze drier freeze drying 24h again and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant by mass percentage by 18% skimmed milk power, the trehalose of 20%, the sodium hydrogen phosphate of 2%, the lactose of 10% and 50% phosphate buffer composition;
Wherein, the activation process of probio specifically comprises:
Under 37 DEG C of condition of culture, adopted by lactobacillus acidophilus MRS fluid nutrient medium to activate three times, the cysteine hydrochloride that Bifidobacterium adds culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium to activate three times under 37 DEG C of condition of culture, transfer with the inoculum concentration of 5% at every turn, wherein all under 37 DEG C of condition of culture, cultivate 20-24h first twice, third time cultivates 18h under 37 DEG C of condition of culture, then carry out microscopy, survey OD value, determine without after miscellaneous bacteria, third time activation to be obtained activating probio.
4) make solid content reach 42% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, raw material sheep breast by spraying dry (EAT is 160 ~ 165 DEG C, and temperature of outgoing air is 75 ~ 65 DEG C) afterwards cool to room temperature cross 40 mesh sieve and obtain goat milk powder;
5) by mass percentage by the goat milk powder of 53.5%, the mixture A of 30%, 1% freeze-drying probiotics bacterial powder, 7% sucrose, 1.0% synanthrin, 7% glucose and 0.5% microcrystalline cellulose adopt rotating speed to be 5 turns/min, and power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Then utilize single-punching tablet press, make unit viable count and reach (1.0-3.0) × 10 7~ (1.0-3.0) × 10 9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum tableting pressure of described tablet press machine: 50KN; Pellet diameter: sheet is heavily 1.0g; Hardness is at 4 ~ 7N.
Embodiment 2:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; Be cut into small pieces after fresh hawthorn is cleaned peeling, then adopt blast drier to be dried to constant weight at 70 DEG C respectively;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are met operative norm Q/12NK4558-2006 by adopting after the mass ratio mixing of 1:1:2:2, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 60 object sieves and obtain mixture A;
3) first, under 37 DEG C of condition of culture, adopted by probio MRS fluid nutrient medium to activate obtain for three times activating probio, get the probio after activation with 3% the fermentation tank culture 18h of inoculum concentration access 10LMRS culture medium, stir once every 4h in incubation, rotating speed 60 turns/min, mixing time 2min, then, probiotics bacterial mud is made with the centrifugal 12min of the rotating speed of 10000 turns/min with centrifuge, then in probiotics bacterial mud, the compound freeze drying protectant of 1mL is added by every g probio mud, vortex mixed instrument is utilized to be mixed even, at-30 DEG C of pre-freeze 18h, move to freeze drier freeze drying 24h again and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant by mass percentage by 50% skimmed milk power, the trehalose of 8%, the sodium hydrogen phosphate of 1%, the lactose of 1% and 40% phosphate buffer composition;
Wherein, the activation process of probio specifically comprises:
Under 37 DEG C of condition of culture, adopted by lactobacillus acidophilus MRS fluid nutrient medium to activate three times, the cysteine hydrochloride that Bifidobacterium adds culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium to activate three times under 37 DEG C of condition of culture, transfer with the inoculum concentration of 5% at every turn, wherein all under 37 DEG C of condition of culture, cultivate 20-24h first twice, third time cultivates 18h under 37 DEG C of condition of culture, then carry out microscopy, survey OD value, determine without after miscellaneous bacteria, third time activation to be obtained activating probio.
4) make solid content reach 45% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, raw material sheep breast by spraying dry (EAT is 160 ~ 165 DEG C, and temperature of outgoing air is 75 ~ 65 DEG C) afterwards cool to room temperature cross 60 mesh sieve and obtain goat milk powder;
5) by mass percentage by the goat milk powder of 80.2%, the mixture A of 10%, 0.1% freeze-drying probiotics bacterial powder, 5% sucrose, 0.5% synanthrin, 4% glucose and 0.2% microcrystalline cellulose adopt rotating speed to be 8 turns/min, and power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Then utilize single-punching tablet press, make unit viable count and reach (1.0-3.0) × 10 7~ (1.0-3.0) × 10 9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum tableting pressure of described tablet press machine: 15KN; Pellet diameter: sheet is heavily 1.4g; Hardness is at 4 ~ 7N.
Embodiment 3:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; Be cut into small pieces after fresh hawthorn is cleaned peeling, then adopt blast drier to be dried to constant weight at 70 DEG C respectively;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are met operative norm Q/12NK4558-2006 by adopting after the mass ratio mixing of 1:1:2:2, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 80 object sieves and obtain mixture A;
3) first, under 37 DEG C of condition of culture, adopted by probio MRS fluid nutrient medium to activate obtain for three times activating probio, get the probio after activation with 4% the fermentation tank culture 18h of inoculum concentration access 10LMRS culture medium, stir once every 3h in incubation, rotating speed 60 turns/min, mixing time 2min, then, probiotics bacterial mud is made with the centrifugal 12min of the rotating speed of 10000 turns/min with centrifuge, then in probiotics bacterial mud, the compound freeze drying protectant of 1mL is added by every g probio mud, vortex mixed instrument is utilized to be mixed even, at-40 DEG C of pre-freeze 12h, move to freeze drier freeze drying 24h again and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant by mass percentage by 18% skimmed milk power, the trehalose of 20%, the sodium hydrogen phosphate of 2%, the lactose of 10% and 50% phosphate buffer composition;
Wherein, the activation process of probio specifically comprises:
Under 37 DEG C of condition of culture, adopted by lactobacillus acidophilus MRS fluid nutrient medium to activate three times, the cysteine hydrochloride that Bifidobacterium adds culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium to activate three times under 37 DEG C of condition of culture, transfer with the inoculum concentration of 5% at every turn, wherein all under 37 DEG C of condition of culture, cultivate 20-24h first twice, third time cultivates 18h under 37 DEG C of condition of culture, then carry out microscopy, survey OD value, determine without after miscellaneous bacteria, third time activation to be obtained activating probio.
4) make solid content reach 42% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, raw material sheep breast by spraying dry (EAT is 160 ~ 165 DEG C, and temperature of outgoing air is 75 ~ 65 DEG C) afterwards cool to room temperature cross 80 mesh sieve and obtain goat milk powder;
5) by mass percentage by the goat milk powder of 60%, the mixture A of 25%, 0.5% freeze-drying probiotics bacterial powder, 6% sucrose, 1.0% synanthrin, 7% glucose and 0.5% microcrystalline cellulose adopt rotating speed to be 5 turns/min, and power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Then utilize single-punching tablet press, make unit viable count and reach (1.0-3.0) × 10 7~ (1.0-3.0) × 10 9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum tableting pressure of described tablet press machine: 50KN; Pellet diameter: sheet is heavily 1.5g; Hardness is at 4 ~ 7N.
Embodiment 4:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; Be cut into small pieces after fresh hawthorn is cleaned peeling, then adopt blast drier to be dried to constant weight at 70 DEG C respectively;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are met operative norm Q/12NK4558-2006 by adopting after the mass ratio mixing of 1:1:2:2, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 50 object sieves and obtain mixture A;
3) first, under 37 DEG C of condition of culture, adopted by probio MRS fluid nutrient medium to activate obtain for three times activating probio, get the probio after activation with 5% the fermentation tank culture 18h of inoculum concentration access 10LMRS culture medium, stir once every 4h in incubation, rotating speed 60 turns/min, mixing time 2min, then, probiotics bacterial mud is made with the centrifugal 12min of the rotating speed of 10000 turns/min with centrifuge, then in probiotics bacterial mud, the compound freeze drying protectant of 1mL is added by every g probio mud, vortex mixed instrument is utilized to be mixed even, at-30 DEG C of pre-freeze 18h, move to freeze drier freeze drying 24h again and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant by mass percentage by 50% skimmed milk power, the trehalose of 8%, the sodium hydrogen phosphate of 1%, the lactose of 1% and 40% phosphate buffer composition;
Wherein, the activation process of probio specifically comprises:
Under 37 DEG C of condition of culture, adopted by lactobacillus acidophilus MRS fluid nutrient medium to activate three times, the cysteine hydrochloride that Bifidobacterium adds culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium to activate three times under 37 DEG C of condition of culture, transfer with the inoculum concentration of 5% at every turn, wherein all under 37 DEG C of condition of culture, cultivate 20-24h first twice, third time cultivates 18h under 37 DEG C of condition of culture, then carry out microscopy, survey OD value, determine without after miscellaneous bacteria, third time activation to be obtained activating probio.
4) make solid content reach 45% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, raw material sheep breast by spraying dry (EAT is 160 ~ 165 DEG C, and temperature of outgoing air is 75 ~ 65 DEG C) afterwards cool to room temperature cross 60 mesh sieve and obtain goat milk powder;
5) by mass percentage by the goat milk powder of 70%, the mixture A of 20%, 0.3% freeze-drying probiotics bacterial powder, 5% sucrose, 0.4% synanthrin, 4% glucose and 0.3% microcrystalline cellulose adopt rotating speed to be 8 turns/min, and power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Then utilize single-punching tablet press, make unit viable count and reach (1.0-3.0) × 10 7~ (1.0-3.0) × 10 9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum tableting pressure of described tablet press machine: 15KN; Pellet diameter: sheet is heavily 1.5g; Hardness is at 4 ~ 7N.
Embodiment 5:
1) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis are dried to constant weight; Be cut into small pieces after fresh hawthorn is cleaned peeling, then adopt blast drier to be dried to constant weight at 70 DEG C respectively;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn are met operative norm Q/12NK4558-2006 by adopting after the mass ratio mixing of 1:1:2:2, power of motor is 1200W, it is Powdered that rotating speed is that the medicinal herb grinder of 2400r/min is ground into, and then crosses 70 object sieves and obtain mixture A;
3) under 37 DEG C of condition of culture, adopted by probio MRS fluid nutrient medium to activate to obtain for three times activating probio, get the probio after activation with 5% the fermentation tank culture 18h of inoculum concentration access 10LMRS culture medium, stir once every 4h in incubation, rotating speed 60 turns/min, mixing time 2min, then, probiotics bacterial mud is made with the centrifugal 12min of the rotating speed of 10000 turns/min with centrifuge, then in probiotics bacterial mud, the compound freeze drying protectant of 1mL is added by every g probio mud, vortex mixed instrument is utilized to be mixed even, at-30 DEG C of pre-freeze 18h, move to freeze drier freeze drying 24h again and obtain freeze-drying probiotics bacterial powder,
Described compound freeze drying protectant by mass percentage by 50% skimmed milk power, the trehalose of 8%, the sodium hydrogen phosphate of 1%, the lactose of 1% and 40% phosphate buffer composition;
Wherein, the activation process of probio specifically comprises:
Under 37 DEG C of condition of culture, adopted by lactobacillus acidophilus MRS fluid nutrient medium to activate three times, the cysteine hydrochloride that Bifidobacterium adds culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium to activate three times under 37 DEG C of condition of culture, transfer with the inoculum concentration of 5% at every turn, wherein all under 37 DEG C of condition of culture, cultivate 20-24h first twice, third time cultivates 18h under 37 DEG C of condition of culture, then carry out microscopy, survey OD value, determine without after miscellaneous bacteria, third time activation to be obtained activating probio.
4) make solid content reach 45% raw material sheep breast reduced pressure concentration after purification and standardization and obtain raw material sheep breast, raw material sheep breast by spraying dry (EAT is 160 ~ 165 DEG C, and temperature of outgoing air is 75 ~ 65 DEG C) afterwards cool to room temperature cross 70 mesh sieve and obtain goat milk powder;
5) by mass percentage by the goat milk powder of 74%, the mixture A of 15%, 0.5% dry probiotics bacterial powder, 5% sucrose, 1% synanthrin, 4% glucose and 0.5% microcrystalline cellulose adopt rotating speed to be 8 turns/min, and power of motor is that the three-dimensional motion mixer of 0.5Kw mixes;
Then utilize single-punching tablet press, make unit viable count and reach (1.0-3.0) × 10 7~ (1.0-3.0) × 10 9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn composite powder probio of cfu/g.
The maximum tableting pressure of described tablet press machine: 15KN; Pellet diameter: sheet is heavily 1.6g; Hardness is at 4 ~ 7N.

Claims (6)

1. a stomach strengthening and digestion promoting probio goat milk sheet, it is characterized in that: the goat milk powder comprising 53.5%-80.2% by mass percentage, the microcrystalline cellulose of the freeze-drying probiotics bacterial powder of the mixture A of 10%-30%, 0.1%-1%, the sucrose of 5%-7%, the synanthrin of 0.5%-1.0%, the glucose of 4%-7% and 0.2%-0.5%; Described freeze-drying probiotics bacterial powder is the mixture of probio and compound freeze drying protectant;
Wherein probio mixes according to the ratio of every g probio with the compound freeze drying protectant of 1mL with compound freeze drying protectant;
Wherein probio adopts viable count to be (1.0-3.0) × 10 11lactobacillus acidophilus bacterium powder, viable count be (1.0-3.0) × 10 11the Mixed Microbes of these two kinds of arbitrary proportions of bifidobacterium bifidum bacterium powder;
Compound freeze drying protectant comprises and comprising by mass percentage: the skimmed milk power of 18%-50%, the trehalose of 8%-20%, the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% phosphate buffer;
Described mixture A is mixed to get by the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and the hawthorn mass ratio by 1:1:2:2.
2. a preparation method for stomach strengthening and digestion promoting probio goat milk sheet, is characterized in that comprising the following steps:
1) constant weight is dried to after fresh hawthorn being cleaned peeling;
2) bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn is Powdered by being ground into after the mass ratio mixing of 1:1:2:2, then cross 40-80 object sieve and obtain mixture A;
3) get the probio after activation with 2 ~ 5% the fermentation tank culture 18h of inoculum concentration access 10LMRS culture medium, stir once every 3-4h in incubation, rotating speed 60 turns/min, mixing time 2min, then, probiotics bacterial mud is made with the centrifugal 12min of the rotating speed of 10000 turns/min with centrifuge, then in probiotics bacterial mud, the compound freeze drying protectant of 1mL is added by every g probio mud, vortex mixed instrument is utilized to be mixed even, at-40 ~-20 DEG C of pre-freeze 12 ~ 24h, then move to freeze drier freeze drying 24h acquisition freeze-drying probiotics bacterial powder; Described probio is viable count is (1.0-3.0) × 10 11lactobacillus acidophilus bacterium powder, viable count be (1.0-3.0) × 10 11the mixing of these two kinds of arbitrary proportions of bifidobacterium bifidum bacterium powder;
Described compound freeze drying protectant comprises: be made up of the phosphate buffer of the trehalose of the skimmed milk power of 18%-50%, 8%-20%, the sodium hydrogen phosphate of 1%-2%, the lactose of 1%-10% and 40%-50% by mass percentage;
4) by sheep breast after purification and standardization, reduced pressure concentration makes solid content reach 42% ~ 50% and obtains raw material sheep breast, crosses 40 ~ 80 mesh sieves by spraying dry and after cool to room temperature and obtains goat milk powder; Described spraying dry EAT is 160 ~ 165 DEG C, and temperature of outgoing air is 75 ~ 65 DEG C;
5) by mass percentage by the goat milk powder of 53.5%-80.2%, the mixture A of 10%-30%, the microcrystalline cellulose of the sucrose of 0.1%-1% freeze-drying probiotics bacterial powder, 5%-7%, the synanthrin of 0.5%-1.0%, the glucose of 4%-7% and 0.2%-0.5% mixes, and obtains mixture B;
Then utilize single-punching tablet press, mixture B is made unit viable count and reaches (1.0-3.0) × 10 7~ (1.0-3.0) × 10 9the stomach strengthening and digestion promoting probio goat milk sheet containing the bighead atractylodes rhizome, the bark of official magnolia, Radix Codonopsis and hawthorn compound probiotic of cfu/g.
3. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 2, is characterized in that: described step 1) drying adopt blast drier 70 DEG C of dryings.
4. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 2, is characterized in that: the activation process of described probio is as follows:
Under 37 DEG C of condition of culture, adopted by lactobacillus acidophilus MRS fluid nutrient medium to activate three times, the cysteine hydrochloride that bifidobacterium bifidum adds culture volume 0.05% in MRS fluid nutrient medium adopts MRS fluid nutrient medium to activate three times under 37 DEG C of condition of culture, transfer with the inoculum concentration of 2 ~ 5% at every turn, wherein all under 37 DEG C of condition of culture, cultivate 20-24h first twice, third time cultivates 18h under 37 DEG C of condition of culture, then carry out microscopy, survey OD value, determine without after miscellaneous bacteria, third time activation to be obtained activating probio.
5. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 2, is characterized in that: described step 5) mixing adopt rotating speed to be 5 ~ 20 turns/min, power of motor is the three-dimensional motion mixer of 0.5Kw.
6. the preparation method of stomach strengthening and digestion promoting probio goat milk sheet as claimed in claim 2, is characterized in that: the maximum tableting pressure of described single-punching tablet press: 50KN; Pellet diameter: sheet is heavily 1.0 ~ 1.6g; Hardness is at 4 ~ 7N.
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824240A (en) * 2006-01-12 2006-08-30 北京阜康仁生物制药科技有限公司 Shenshu Jianpi medicinal preparation for invigorating spleen and its new preparation method
CN1895610A (en) * 2006-06-26 2007-01-17 河南康鑫药业有限公司 Preparation for digestant and nourishing-kidney tablets by micropowder technology
CN102742653A (en) * 2012-07-10 2012-10-24 陕西科技大学 Brain-strengthening and nerve soothing probiotic goat milk tablet and preparation method of brain-strengthening and nerve soothing probiotic goat milk tablet
CN102754695A (en) * 2012-07-10 2012-10-31 陕西科技大学 Burdock probiotics goat milk slices and method for preparing same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824240A (en) * 2006-01-12 2006-08-30 北京阜康仁生物制药科技有限公司 Shenshu Jianpi medicinal preparation for invigorating spleen and its new preparation method
CN1895610A (en) * 2006-06-26 2007-01-17 河南康鑫药业有限公司 Preparation for digestant and nourishing-kidney tablets by micropowder technology
CN102742653A (en) * 2012-07-10 2012-10-24 陕西科技大学 Brain-strengthening and nerve soothing probiotic goat milk tablet and preparation method of brain-strengthening and nerve soothing probiotic goat milk tablet
CN102754695A (en) * 2012-07-10 2012-10-31 陕西科技大学 Burdock probiotics goat milk slices and method for preparing same

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