CN1895610A - Preparation for digestant and nourishing-kidney tablets by micropowder technology - Google Patents
Preparation for digestant and nourishing-kidney tablets by micropowder technology Download PDFInfo
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Abstract
A process for preparing the 'Stomach-nourishing digestion-helping tablet' includes such steps as proportionally mixing 6 Chinese-medicinal materials including cyperus tuber, tuckahoe, etc and pulverizing, cutting another 4 Chinese-medicinal materials including atractylodes rhizome, tangerine peel, etc, proportional mixing, heating to take volatile oil, proportionally decocting final 7 Chinese-medicinal materials including liquorice root, haw, etc three times, collecting decoction, filtering, concentrating, mixing them together, granulating, adding magnesium stearate, and die pressing.
Description
One, technical field
The present invention relates to field of medicaments, particularly a kind of preparation method of utilizing micropowder technology to produce stomach-nourishing digestion-helping tablet.
Two, background technology
Stomach-nourishing digestion-helping tablet is the Chinese patent medicine of newly developing in recent years, and major function is the stomach function regulating preventing or arresting vomiting, the chest stuffiness relieving of having a respite.Be used for both sides of the chest distension, gastral cavilty that weakness of the spleen and stomach, dyspepsia cause and ache, fall full noisy, acid regurgitation, bread is sallow, the extremity asthenia.Be Rhizoma Cyperi, the Radix Aucklandiae, Poria, Fructus Amomi, six songs, Pinellia leaven Six-element Chinese medicine powder to be broken into fine powder (by the sieve of internal diameter 180 μ m) directly be used as medicine among the preparation technology.Be widely used in the clinical treatment of weakness of the spleen and stomach, but in clinical practice, part patient reflects that curative effect is not ideal enough.
Three, summary of the invention
The objective of the invention is not ideal enough this problem of pharmaceutical effectiveness at the clinical patients reflection, from production technology innovation angle, a kind of preparation method of utilizing micropowder technology to produce stomach-nourishing digestion-helping tablet is provided, thereby improved the stripping of ingredient, improve clinical efficacy, overcome the low problem of pharmaceutical effectiveness.
The objective of the invention is to realize by following scheme: this stomach-nourishing digestion-helping tablet is to be made by the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Cyperi, Fructus Amomi, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the Radix Aucklandiae, Fructus Crataegi cuneatae, six songs, Fructus Hordei Germinatus, Herba Pogostemonis, Semen Raphani, Fructus Aurantii, Pinellia leaven, Radix Codonopsis, its step is, it is clean towards drip washing to get Radix Aucklandiae water, put the baking oven inner drying, Rhizoma Cyperi, the Radix Aucklandiae, Fructus Amomi, six songs, Poria, Pinellia leaven are mixed in proportion the back to be pulverized, with evenly back sterilization of powder mixes, stand-by; Get Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Fructus Aurantii, Herba Pogostemonis and cut into decoction pieces, be mixed in proportion, put in the multi-function extractor, add water, volatile oil is extracted in heating, and it is stand-by to collect volatile oil; Said extracted volatile oil is got the Rhizoma Atractylodis Macrocephalae, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Fructus Crataegi cuneatae, Fructus Hordei Germinatus, Semen Raphani, Radix Codonopsis after finishing, and the seven-flavor drink sheet after being mixed in proportion, adds water, decocts three times, merges decoction liquor, filters, and is condensed into extractum; With above-mentioned Chinese medicinal powder and extractum mix homogeneously, granulate, spray into volatile oil and stir evenly; vexed putting adds magnesium stearate, behind the mix homogeneously; be pressed into tablet, that is, or with above-mentioned Chinese medicinal powder and extractum mix homogeneously; drying gets dry extract, crushing screening; through dry granulation mechanism grain, spray into above-mentioned collection volatile oil in the granule again, stir evenly; vexed putting adds magnesium stearate, behind the mix homogeneously; be pressed into tablet, that is, and through dry granulation mechanism grain; get granule; spray into above-mentioned collection volatile oil in the granule, stir evenly, vexed putting; add magnesium stearate; behind the mix homogeneously, be pressed into tablet, promptly; the present invention utilizes stomach-nourishing digestion-helping tablet that micropowder technology prepares than common stomach-nourishing digestion-helping tablet in essence raising to be arranged on quality and curative effect; not only effective ingredient is fully utilized, and has improved curative effect greatly, and has opened promoting digestion and nourishing stomach; improve a new way of people's healthy quality; actual production and clinical meaning are arranged, have huge economic and social benefit.
Four, the specific embodiment
Below in conjunction with practical situation the specific embodiment of the present invention is elaborated.
Provided by the aforementioned techniques scheme, stomach-nourishing digestion-helping tablet of the present invention is prepared from by following compositions in weight percentage:
Rhizoma Atractylodis Macrocephalae 8-11%, Poria 5-8%, Rhizoma Cyperi 5-8%, Fructus Amomi 5-8%, Rhizoma Atractylodis 5-8%, Cortex Magnoliae Officinalis 5-8%, Pericarpium Citri Reticulatae 12-14%, Radix Glycyrrhizae 1-3%, Radix Aucklandiae 1-3%, Fructus Crataegi cuneatae 5-8%, six bent 5-8%, Fructus Hordei Germinatus 5-8%, Herba Pogostemonis 5-8%, Semen Raphani 2-4%, Fructus Aurantii 5-8%, Pinellia leaven 2-4%, Radix Codonopsis 2-4%, wherein by the Chinese medicine processing requirement, the Rhizoma Atractylodis Macrocephalae is a Rhizoma Atractylodis Macrocephalae (parched with bran); Rhizoma Cyperi is that vinegar is fried Rhizoma Cyperi; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Six is bent for adopting Semen Armeniacae Amarum mud, Semen Phaseoli, Herba polygoni hydropiperis, Herba Artemisiae Annuae, flour, the mixing of Herba Xanthii grass medicamental pulverata after the processed goods that fermentation forms through parched with bran, is called bran stir-baked MASS FERMENTATA MEDICINALIS (seeing the record of traditional Chinese medical science five tastes garden); Fructus Hordei Germinatus is Fructus Hordei Germinatus (parched); Semen Raphani is a Semen Raphani (parched); Fructus Aurantii is for removing the heart, parched with bran Fructus Aurantii; Radix Codonopsis is for removing Lu Dangcan.
Its preparation method comprises following processing step successively:
1, it is clean towards drip washing to get Radix Aucklandiae water, put in the baking oven, it is dry under 40-60 ℃ of condition to adjust temperature, pulverized 75 μ m aperture sieve after Rhizoma Cyperi, the Radix Aucklandiae, Fructus Amomi, six songs, Poria, Pinellia leaven mixed according to the above ratio, with powder mixes evenly after, sterilization is 10-30 minute under 115-125 ℃ of condition, and it is stand-by to get Chinese medicinal powder;
2, get Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Fructus Aurantii, Herba Pogostemonis, decoction pieces and mix according to the above ratio, put in the multi-function extractor, add 6-10 times of water gaging, heated 1.5-3 hour, extract volatile oil, it is stand-by to collect volatile oil;
3, after said extracted volatile oil finishes, get the Rhizoma Atractylodis Macrocephalae, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Fructus Crataegi cuneatae, Fructus Hordei Germinatus, Semen Raphani, Radix Codonopsis and cut into the seven-flavor drink sheet, after mixing according to the above ratio, join in the multi-function extractor, add water 4-10 times, decoct three times to the decoction pieces gross weight, each 1.5-2.5 hour, merge decoction liquor, filter, filtrate is concentrated to the extractum of density 1.15-1.30 (measuring under 60-80 ℃ of condition);
4; with above-mentioned Chinese medicinal powder and extractum mix homogeneously; granulate with the 12-18 eye mesh screen; dried particles under 60-80 ℃ of condition; through the 10-16 mesh sieve, granulate sprays into above-mentioned collection volatile oil and stirs evenly in the granule after granulate is qualified again; vexed 0.5-1.5 hour; add the magnesium stearate of 0.25-1% particle weight, behind the mix homogeneously, be pressed into tablet; promptly; or with above-mentioned Chinese medicinal powder and extractum mix homogeneously, dry under 60-80 ℃ of condition, get dry extract; with the broken 60-100 mesh sieve of crossing of dried cream powder; get powder, through dry granulation mechanism grain, spray into above-mentioned collection volatile oil in the granule again; stir evenly; vexed 0.5-1.5 hour, the magnesium stearate of adding 0.25-1% particle weight was behind the mix homogeneously; be pressed into tablet; that is, or above-mentioned extractum is dry under 60-80 ℃ of condition, get dry extract; with the broken 80-100 mesh sieve of crossing of dried cream powder; the powder that gets dry extract is behind dried cream powder and the above-mentioned Chinese medicinal powder mix homogeneously, through dry granulation mechanism grain; get granule; spray into above-mentioned collection volatile oil in the granule, stir evenly, vexed 0.5-1.5 hour; the magnesium stearate that adds the 0.25-1% particle weight; behind the mix homogeneously, be pressed into tablet, promptly.
Embodiment 1
1, it is clean towards drip washing to get Radix Aucklandiae water, puts in the baking oven, dries under 40 ℃ of conditions, gets the exsiccant Radix Aucklandiae 200 grams, Rhizoma Cyperi (vinegar stir-fry) 800 grams, Fructus Amomi 800 grams, Poria 800 grams, six songs (parched with bran), 800 grams, Pinellia leaven 400 grams mix the Six-element Chinese crude drug, with the pulverizer pulverizing and by 75 μ m aperture sieve.Powder mixes is even, through sterilization under 120 ℃ of conditions 20 minutes, get Chinese medicinal powder;
2, get Rhizoma Atractylodis (stir-fry) 800 grams, Pericarpium Citri Reticulatae 1600 grams, Fructus Aurantii (removing the heart, parched with bran) 800 grams, Herba Pogostemonis 800 grams cut into the four flavor prepared slices of Chinese crude drugs, put into after the mixing in the multi-function extractor, add 8 times of water gagings of Chinese medicine, heated 1.5-3 hour, and extracted volatile oil, it is stand-by to collect volatile oil;
3, get the Rhizoma Atractylodis Macrocephalae (parched with bran) 1200 grams, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 800 grams, Radix Glycyrrhizae 200 grams, Fructus Crataegi cuneatae 800 grams, Semen Raphani (stir-fry) 400 grams, Radix Codonopsis (going reed) 400 grams, Fructus Hordei Germinatus (stir-fry) the 800 grams seven flavor prepared slices of Chinese crude drugs are put into the multi-function extractor of having carried volatile oil, add 8 times of water gagings of the prepared slices of Chinese crude drugs, heated and boiled 2 hours, the filtration medicinal liquid is standby, and medicinal residues add 6 times of water gagings of Chinese medicine total amount, continue to boil 2 hours, the filtration medicinal liquid is standby, medicinal residues add 4 times of water gagings of Chinese medicine total amount, continue to boil 2 hours, filter medicinal liquid and above-mentioned twice filtrate merging, concentrated filtrate is to density, the extractum of 1.25 (measuring under 80 ℃ of conditions);
4, with above-mentioned Chinese medicinal powder and extractum mix homogeneously, granulate with 16 eye mesh screens, granule is put in the ebullated dryer, and dry under 80 ℃ of conditions, dried particles is through 14 mesh sieve granulate, spray into the volatile oil of above-mentioned collection in the granule after qualified through granulate, stir evenly, vexed 1 hour, add the magnesium stearate of 1% particle weight, make tablet behind the mix homogeneously, promptly.
Example 2
1, it is clean towards drip washing to get Radix Aucklandiae water, puts in the baking oven, dries under 40 ℃ of conditions, get the exsiccant Radix Aucklandiae 200 grams, Rhizoma Cyperi (vinegar stir-fry) 800 grams, Fructus Amomi 800 grams, Poria 800 grams, six songs (parched with bran), 800 grams, Pinellia leaven 400 grams, Six-element Chinese medicine is mixed, pulverize with pulverizer, by 75 μ m aperture sieve, that powder mixes is even, through sterilization under 120 ℃ of conditions 20 minutes, get Chinese medicinal powder;
2, get Rhizoma Atractylodis (stir-fry) 800 grams, Pericarpium Citri Reticulatae 1600 grams, Fructus Aurantii (removing the heart, parched with bran) 800 grams, Herba Pogostemonis 800 grams cut into the four flavor prepared slices of Chinese crude drugs, put into after the mixing in the multi-function extractor, add 8 times of water gagings of Chinese medicine, heated 1.5-3 hour, and extracted volatile oil, it is stand-by to collect volatile oil;
3, get the Rhizoma Atractylodis Macrocephalae (parched with bran) 1200 grams, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 800 grams, Radix Glycyrrhizae 200 grams, Fructus Crataegi cuneatae 800 grams, Semen Raphani (stir-fry) 400 grams, Radix Codonopsis (going reed) 400 grams, Fructus Hordei Germinatus (stir-fry) the 800 grams seven flavor prepared slices of Chinese crude drugs, put into the multi-function extractor of having carried volatile oil, add 8 times of water gagings of the prepared slices of Chinese crude drugs, heated and boiled 2 hours, the filtration medicinal liquid is standby, medicinal residues add 6 times of water gagings of Chinese medicine total amount, continue to boil 2 hours, and it is standby to filter medicinal liquid, medicinal residues add 4 times of water gagings of Chinese medicine total amount, continued to boil 2 hours, and filtered medicinal liquid and above-mentioned twice filtrate merging, concentrated filtrate is the extractum of 1.25 (measuring under 80 ℃ of conditions) to density;
4, with behind above-mentioned Chinese medicinal powder and the extractum mix homogeneously; dry under 80 ℃ of conditions, get dry extract, with broken mistake 60 mesh sieves of dried cream powder; get powder; make granule through the dry granulation machine, spray into the volatile oil of above-mentioned collection in the granule, stir evenly; vexed 1 hour; the magnesium stearate that adds 1% particle weight is made tablet, promptly behind the mix homogeneously.
Example 3
1, it is clean towards drip washing to get Radix Aucklandiae water, puts in the baking oven, dries under 40 ℃ of conditions, get the exsiccant Radix Aucklandiae 200 grams, Rhizoma Cyperi (vinegar stir-fry) 800 grams, Fructus Amomi 800 grams, Poria 800 grams, six songs (parched with bran), 800 grams, Pinellia leaven 400 grams, Six-element Chinese medicine is mixed, pulverize with pulverizer, by 75 μ m aperture sieve, that powder mixes is even, through sterilization under 120 ℃ of conditions 20 minutes, get Chinese medicinal powder;
2, get Rhizoma Atractylodis (stir-fry) 800 grams, Pericarpium Citri Reticulatae 1600 grams, Fructus Aurantii (removing the heart, parched with bran) 800 grams, Herba Pogostemonis 800 grams cut into the four flavor prepared slices of Chinese crude drugs, put into after the mixing in the multi-function extractor, add 8 times of water gagings of Chinese medicine, heated 1.5-3 hour, and extracted volatile oil, it is stand-by to collect volatile oil;
3, get the Rhizoma Atractylodis Macrocephalae (parched with bran) 1200 grams, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 800 grams, Radix Glycyrrhizae 200 grams, Fructus Crataegi cuneatae 800 grams, Semen Raphani (stir-fry) 400 grams, Radix Codonopsis (going reed) 400 grams, Fructus Hordei Germinatus (stir-fry) the 800 grams seven flavor prepared slices of Chinese crude drugs, put into the multi-function extractor of having carried volatile oil, add 8 times of water gagings of the prepared slices of Chinese crude drugs, heated and boiled 2 hours, the filtration medicinal liquid is standby, medicinal residues add 6 times of water gagings of Chinese medicine total amount, continue to boil 2 hours, and it is standby to filter medicinal liquid, medicinal residues add 4 times of water gagings of Chinese medicine total amount, continued to boil 2 hours, and filtered medicinal liquid and above-mentioned twice filtrate merging, concentrated filtrate is the extractum of 1.25 (measuring under 80 ℃ of conditions) to density;
4, above-mentioned extractum is dry under 80 ℃ of conditions; get dry extract, with broken mistake 80 mesh sieves of dried cream powder, powder gets dry extract; behind dried cream powder and the above-mentioned Chinese medicinal powder mix homogeneously; through the machine-processed granule that gets of dry granulation, in granule, spray into above-mentioned collection volatile oil, stir evenly; vexed 1 hour; the magnesium stearate that adds 1% particle weight is pressed into tablet, promptly behind the mix homogeneously.
From the above, the present invention utilizes the micropowder technology processing and preparing to form in Chinese medicine, through clinical experiment and mensuration, substantial improvement is arranged and obviously improve curative effect with original medicine, and its clinical data is as follows:
One, selects case
Every have weakness of the spleen and stomach at outpatient service or inpatient, and both sides of the chest distension, gastral cavilty that dyspepsia causes are had a pain, noisy, the acid regurgitation that falls to satisfy, and symptoms such as shallow complexion, extremity asthenia all as the object of selecting case.
Two, diagnostic criteria
Primary symptom: gastral cavilty distension or dull pain, the happiness of stomach pain relieved by pressing is warm, loose stool, weak, pale tongue, there is indentation on the limit.
Inferior disease: lack of appetite, breathe hard, lazy speech, vomiting clear water, tastelessness, thready and weak pulse.
Possess 2 of above primary symptoms, 3 of inferior diseases can be diagnosed sick for this reason.
Exclusion standard:
1, merge peptic ulcer, gastric mucosa has severe dysplasia or pathological diagnosis to be suspected to have the person of cancerating.
2, merge serious primary disease such as the heart, brain, liver, kidney and hemopoietic system, psychotic.
3, gestation or preparation gravid woman, women breast-feeding their children.
4, allergic constitution and to multiple drug allergy person.
Three, therapeutic scheme
8 of the each clothes of patient, every 0.3 gram is obeyed 2 every day, and two months is a course of treatment, carries out the curative effect inspection after taking a course of treatment, and establishes matched group and contrast treatment relatively.The present invention is ground into powder with the Radix Aucklandiae, Rhizoma Cyperi, Fructus Amomi, Poria, six songs, Pinellia leaven, crosses 75 μ m aperture sieve, and makes stomach-nourishing digestion-helping tablet (the present invention claims that its medicine is A).Above-mentioned Six-element Chinese medicine powder is broken into powder, crosses 180 μ m aperture sieve and the stomach-nourishing digestion-helping tablet (the present invention claims that its medicine is B) made compares.
Four, therapeutic effect of syndrome evaluation criteria
1, clinical recovery: symptom, sign disappear or basic the disappearance, and the syndrome integration reduces 〉=95%.
2, produce effects: symptom, sign is obviously improved, and the syndrome integration reduces 〉=70%.
3, effective: symptom, sign all take a favorable turn, and the syndrome integration reduces 〉=30%.
4, invalid: card shape, sign all do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%.Computing formula (nimodipine method) is: [integration before (integration before the treatment-treatment back integration) ÷ treatment] * 100%.
Five, statistical disposition
Through 79 weakness of the spleen and stomach patients are compared treatment, divide two groups at random, medicine A wherein of the present invention organizes 37 people, and common drug B organizes 42 people, takes by therapeutic scheme and checks that through statistics, its efficacy result is as follows after two months:
The clinical efficacy contrast of A and two kinds of medicines of B
| Medicine | Case | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate (%) |
| A | 37 | 9 | 11 | 15 | 2 | 94.6 |
| B | 42 | 5 | 9 | 21 | 7 | 83.3 |
The A medicine obviously is better than B medicine (P＜0.01) aspect clinical efficacy
Two kinds of medicines of A and B compare in the curative effect of main clinic symptoms
| Symptom | Medicine | Case | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate (%) |
| The gastral cavilty distension | A | 34 | 8 | 12 | 13 | 1 | 97.1 |
| B | 38 | 6 | 12 | 17 | 3 | 92.1 | |
| Stomachache | A | 27 | 6 | 9 | 8 | 4 | 85.2 |
| B | 34 | 5 | 13 | 9 | 7 | 79.4 | |
| Loose stool | A | 33 | 7 | 8 | 14 | 4 | 87.9 |
| B | 37 | 7 | 5 | 19 | 6 | 83.8 | |
| Lack of appetite | A | 31 | 5 | 12 | 12 | 2 | 93.5 |
| B | 36 | 6 | 10 | 13 | 7 | 80.6 | |
| The vomiting clear water | A | 25 | 8 | 6 | 10 | 1 | 96.0 |
| B | 28 | 7 | 8 | 8 | 5 | 82.1 |
Also be better than the B medicine at A medicine aspect the curative effect of main clinic symptoms.
Why two kinds of stomach-nourishing digestion-helping tablets have notable difference on curative effect, have obtained proof through the Chinese medicinal powder composition stripping contrast experiment of different degrees of grinding in two kinds of medicines:
Directly pulverize the Six-element Chinese medicines such as the Radix Aucklandiae that are used as medicine,, be called the A powder in the present invention through pulverizing the Chinese medicinal powder of 75 μ m aperture sieve.Through pulverizing the Chinese medicinal powder of 180 μ m aperture sieve, be called the B powder in the present invention.Two kinds of powder are carried out composition stripping contrast experiment, and the result is by 2005 editions appendix XA of Chinese Pharmacopoeia determination of extractives method (concentration of alcohol is 50%):
| Powder | A | B |
| Water-soluble extractives (%) | 41.3 | 29.3 |
| Ethanol-soluble extractives (%) | 34.7 | 26.9 |
By table as seen, the A powder improves 12% than the water-soluble extractives of B powder, and ethanol-soluble extractives has improved 7.8%.Therefore, the A powder has the effect that promotes the Chinese medicine ingredients stripping than B powder, thereby has improved Chinese medicine utilization rate of active components height, good effect, and this is the place of micropowder technology creativeness in the present invention, also is that core of the present invention is with crucial.
Six, conclusion
By above-mentioned situation as can be seen, utilize stomach-nourishing digestion-helping tablet that micropowder technology prepares in essence raising all to be arranged on quality and curative effect than common stomach-nourishing digestion-helping tablet, not only effective ingredient is fully utilized, improved curative effect greatly, and opened promoting digestion and nourishing stomach, improved new way of people's healthy quality, actual production and clinical meaning are arranged, have huge economic and social benefit.
Claims (3)
1, a kind of preparation method of utilizing micropowder technology to produce stomach-nourishing digestion-helping tablet is characterized in that, by by weight percentage: Rhizoma Atractylodis Macrocephalae 8-11%, Poria 5-8%, Rhizoma Cyperi 5-8%, Fructus Amomi 5-8%, Rhizoma Atractylodis 5-8%, Cortex Magnoliae Officinalis 5-8%, Pericarpium Citri Reticulatae 12-14%, Radix Glycyrrhizae 1-3%, Radix Aucklandiae 1-3%, Fructus Crataegi cuneatae 5-8%, six bent 5-8%, Fructus Hordei Germinatus 5-8%, Herba Pogostemonis 5-8%, Semen Raphani 2-4%, Fructus Aurantii 5-8%, Pinellia leaven 2-4%, Radix Codonopsis 2-4% makes, and its preparation methods steps is:
(1), it is clean towards drip washing to get Radix Aucklandiae water, put in the baking oven, it is dry under 40-60 ℃ of condition to adjust temperature, pulverized 75 μ m aperture sieve after Rhizoma Cyperi, the Radix Aucklandiae, Fructus Amomi, six songs, Poria, Pinellia leaven mixed according to the above ratio, with powder mixes evenly after, sterilization is 10-30 minute under 115-125 ℃ of condition, and it is stand-by to get Chinese medicinal powder;
(2), get Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Fructus Aurantii, Herba Pogostemonis, decoction pieces and mix according to the above ratio, put in the multi-function extractor, add 6-10 times of water gaging, heated 1.5-3 hour, extract volatile oil, it is stand-by to collect volatile oil;
(3), after said extracted volatile oil finishes, get the Rhizoma Atractylodis Macrocephalae, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Fructus Crataegi cuneatae, Fructus Hordei Germinatus, Semen Raphani, Radix Codonopsis and cut into the seven-flavor drink sheet, after mixing according to the above ratio, join in the multi-function extractor, add water 4-10 times, decoct three times to the decoction pieces gross weight, each 1.5-2.5 hour, merge decoction liquor, filter, filtrate is concentrated to the extractum of density 1.15-1.30;
(4); with above-mentioned Chinese medicinal powder and extractum mix homogeneously; granulate with the 12-18 eye mesh screen; dried particles under 60-80 ℃ of condition; again through the 10-16 mesh sieve; granulate; spraying into above-mentioned collection volatile oil in the granule after granulate is qualified stirs evenly; vexed 0.5-1.5 hour; the magnesium stearate that adds the 0.25-1% particle weight; behind the mix homogeneously, be pressed into tablet or with above-mentioned Chinese medicinal powder and extractum mix homogeneously, dry under 60-80 ℃ of condition; get dry extract; with the broken 60-100 mesh sieve of crossing of dried cream powder, get powder, again through dry granulation mechanism grain; spray into above-mentioned collection volatile oil in the granule; stir evenly, vexed 0.5-1.5 hour, the magnesium stearate of adding 0.25-1% particle weight; behind the mix homogeneously; be pressed into tablet or above-mentioned extractum is dry under 60-80 ℃ of condition, get dry extract, with the broken 80-100 mesh sieve of crossing of dried cream powder; powder gets dry extract; behind dried cream powder and the above-mentioned Chinese medicinal powder mix homogeneously,, get granule through dry granulation mechanism grain; spray into above-mentioned collection volatile oil in the granule; stir evenly, vexed 0.5-1.5 hour, the magnesium stearate of adding 0.25-1% particle weight; behind the mix homogeneously, be pressed into tablet.
2, the preparation method of utilizing micropowder technology to produce stomach-nourishing digestion-helping tablet according to claim 1 is characterized in that the said Rhizoma Atractylodis Macrocephalae is a Rhizoma Atractylodis Macrocephalae (parched with bran); Rhizoma Cyperi is that vinegar is fried Rhizoma Cyperi; Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Six is bent for adopting Semen Armeniacae Amarum mud, Semen Phaseoli, Herba polygoni hydropiperis, Herba Artemisiae Annuae, flour, Herba Xanthii grass medicamental pulverata to mix after the processed goods that fermentation forms becomes the bran stir-baked MASS FERMENTATA MEDICINALIS through parched with bran; Fructus Hordei Germinatus is Fructus Hordei Germinatus (parched); Semen Raphani is a Semen Raphani (parched); Fructus Aurantii is for removing the heart, parched with bran Fructus Aurantii; Radix Codonopsis is for removing Lu Dangcan.
3, the preparation method of utilizing micropowder technology to produce stomach-nourishing digestion-helping tablet according to claim 1 is characterized in that being:
(1), to get Radix Aucklandiae water clean towards drip washing, puts in the baking oven, dries under 40 ℃ of conditions, gets the exsiccant Radix Aucklandiae 200 grams, Rhizoma Cyperi 800 grams, Fructus Amomi 800 grams, Poria 800 grams, six bent 800 grams, Pinellia leaven 400 grams mix the Six-element Chinese crude drug, with the pulverizer pulverizing and by 75 μ m aperture sieve.Powder mixes is even, through sterilization under 120 ℃ of conditions 20 minutes, get Chinese medicinal powder;
(2), get Rhizoma Atractylodis 800 gram, Pericarpium Citri Reticulatae 1600 grams, Fructus Aurantii 800 grams, Herba Pogostemonis 800 grams cut into the four flavor prepared slices of Chinese crude drugs, put into after the mixing in the multi-function extractor, add 8 times of water gagings of Chinese medicine, heats 1.5-3 hour, extract volatile oil, collection volatile oil is stand-by;
(3), get the Rhizoma Atractylodis Macrocephalae 1200 grams, Cortex Magnoliae Officinalis 800 grams, Radix Glycyrrhizae 200 grams, Fructus Crataegi cuneatae 800 grams, Semen Raphani 400 grams, Radix Codonopsis 400 grams, the Fructus Hordei Germinatus 800 grams seven flavor prepared slices of Chinese crude drugs are put into the multi-function extractor of having carried volatile oil, add 8 times of water gagings of the prepared slices of Chinese crude drugs, heated and boiled 2 hours, the filtration medicinal liquid is standby, and medicinal residues add 6 times of water gagings of Chinese medicine total amount, continue to boil 2 hours, the filtration medicinal liquid is standby, medicinal residues add 4 times of water gagings of Chinese medicine total amount, continue to boil 2 hours, filter medicinal liquid and above-mentioned twice filtrate merging, concentrated filtrate is to density, 1.25 extractum;
(4); with above-mentioned Chinese medicinal powder and extractum mix homogeneously; granulate with 16 eye mesh screens; granule is put in the ebullated dryer; dry under 80 ℃ of conditions; dried particles is through 14 mesh sieve granulate; spray into the volatile oil of above-mentioned collection in the granule after qualified through granulate; stir evenly; vexed 1 hour; the magnesium stearate that adds 1% particle weight; make tablet behind the mix homogeneously or with behind above-mentioned Chinese medicinal powder and the extractum mix homogeneously; dry under 80 ℃ of conditions, get dry extract, with broken mistake 60 mesh sieves of dried cream powder; get powder; make granule through the dry granulation machine, spray into the volatile oil of above-mentioned collection in the granule, stir evenly; vexed 1 hour; the magnesium stearate that adds 1% particle weight is made tablet or above-mentioned extractum is dry under 80 ℃ of conditions behind the mix homogeneously, get dry extract; with broken mistake 80 mesh sieves of dried cream powder; the powder that gets dry extract, behind dried cream powder and the above-mentioned Chinese medicinal powder mix homogeneously, through dry granulation machine-processed granule; in granule, spray into above-mentioned collection volatile oil; stir evenly, vexed 1 hour, add the magnesium stearate of 1% particle weight; be pressed into tablet behind the mix homogeneously, promptly.
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Address after: 477150 No. 168 Jinxing Road, Dancheng County, Zhoukou City, Henan Province Patentee after: Henan Bainian Kangxin Pharma Co., Ltd. Address before: 477150 No. 168 Jinxing Road, Dancheng County, Henan Province Patentee before: Kangxin Pharmaceutical Co., Ltd., Henan |
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