CN102166329B - Medicine for treating leukopenia caused by chronic hepatitis B or interferon and preparation method thereof - Google Patents

Abstract

The invention relates to a medicine for treating leukopenia caused by chronic hepatitis B or interferon treatment for treating chronic hepatitis B and a preparation method thereof. The medicine is characterized by being prepared from the following important ingredients: 20 to 30 grams of astragalus root, 6 to 10 grams of Chinese angelica, 8 to 12 grams of common burreed rhizome, 8 to 12 grams of curcuma phaeocaulis valeton, 8 to 12 grams ofprepared rehmannia root, 8 to 12 grams of white paeony root, 8 to 12 grams of hairy asiabell root, and 3 to 5 grams of fried liquorice. The preparation method of the medicine comprises following steps of cleaning the above ingredients, sieving, refining honey, and then, producing medicinal pills. The medicine has advantages of simpleness in preparation, convenience in taking, excellent and durable curative effect, no toxic or side effects, and low cost, and is especially suitable for treating patients with leukopenia caused by chronic hepatitis B or interferon treatment for treating chronic hepatitis B.

Description

A kind of treatment chronic hepatitis B or trouble chronic hepatitis B are with leukopenic medicine due to the interferon therapy and preparation method thereof

Technical field:

The present invention relates to a kind of Chinese herbal medicine, particularly a kind of treatment chronic hepatitis B or trouble chronic hepatitis B are with leukopenic medicine due to the interferon therapy and preparation method thereof.

Background technology:

Chronic hepatitis B is one of common chronic infectious disease of China, and serious harm people ' s health, leukopenia are the common situation in the therapeutic process that reaches in its pathogenic process.Leukopenia is meant that the PBL counting continues to be lower than normal value 4 * 10 ⁹/ L, its paathogenic factor is a lot, like ionizing radiation, chemical toxicant (like benzene etc.), Cytotoxic drugs, malnutrition, malignant tumor, leukemia, viral hepatitis etc.Wherein, Majority is optimum process; But person due to (the most common is adverse Reaction of Interferon) in chronic hepatitis B and the therapeutic process thereof; Single still effective when just sending out with leucogen, batilol, DIYU SHENGBAI PIAN etc., do not send out the many unsatisfactory curative effects of person again, and the said medicine composition is single, price is higher, curative effect is difficult for lastingly.

Summary of the invention:

The object of the invention be exactly to provide a kind of make simple, taking convenience, evident in efficacy and lasting, have no side effect, cheap treatment chronic hepatitis B or suffer from chronic hepatitis B with leukopenic medicine due to the interferon therapy and preparation method thereof.

The objective of the invention is to realize like this: a kind of treatment chronic hepatitis B or trouble chronic hepatitis B is characterized in that it mainly is grouped into by following one-tenth: Radix Astragali 20-30g, Radix Angelicae Sinensis 6-10g, triangular 8-12g, Rhizoma Curcumae 8-12g, Radix Rehmanniae Preparata 8-12g, Radix Paeoniae Alba 8-12g, Radix Codonopsis 8-12g, Radix Glycyrrhizae Preparata 3-5g with leukopenic medicine due to the interferon therapy and preparation method thereof.

Method for preparing of the present invention may further comprise the steps:

1) cleans: raw material is mixed, clean up with clear water;

2) sieve: cleaned raw material is put into drying baker dry, grind into powder then, reuse 100 purpose sieves sieve raw material, and the medicamental pulverata that granule is little filters out, and for future use, grinding into powder again that granule is big sieved;

3) refining Mel: Mel is put into pot with the low baking temperature refining, coagulate like the maltosemalt sugar shape, the not order of stirring is burnt, and the addition of Mel is 1 times of raw-material weight;

4) process pill: the Mel of refining is mixed with above-mentioned medicamental pulverata rubs by evenly, placement pact half an hour, rub once more by, the honeyed pill of processing about 6g gets final product.

The present invention also can be made into medicamental pulverata electuary, capsule.

The major function of each component of the present invention:

The Radix Astragali: tonifying Qi and lifting yang, benefiting QI for strengthening the superficies, inducing diuresis to remove edema, holder skin ulcer granulation promoting are monarch drug; Contain glycoside, polysaccharide, aminoacid and trace element etc.; Have Ramulus Uncariae cum Uncis alkali, isorhynchophylline etc., the Ramulus Uncariae Cum Uncis decoct is injected to mouse peritoneal, can produce tangible sedation; Its ethanol extract can be prevented the outbreak of Cavia porcellus epilepsy reaction, and the irritability of maincenter motor analyzer is increased has certain inhibitory action.

Radix Angelicae Sinensis: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving, with Ramulus Uncariae Cum Uncis be monarch drug altogether, the iodine of carbonated calcium, organic matter and magnesium, ferrum, silicate, phosphate, chloride and denier has sedation, too much gastric acid under one's belt can neutralize.

Radix Codonopsis: resuscitation inducing and mind tranquilizing, removing dampness to restore normal function of the stomach are ministerial drug, contain volatile oil, aminoacid, organic acid and saccharide, and its water decoction, volatile oil have sedation, and water decoction has anticonvulsant action.

Radix Rehmanniae Preparata: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI are ministerial drug; Contain glycoside, several amino acids, volatile oil, Saponin, choline etc., coughing centre is had sedation, can remove bronchospasm; And bronchus secretion is reduced and Antitussive and Expectorant Effect is arranged; Can suppress vomiting center and preventing or arresting vomiting, it is intrinsic pressure that decoct can reduce lagophthalmos, and the stopping nausea and vomiting by lowering the adverse flow of QI effect is better behind the processed with Rhizoma Zingiberis Recens.

The Radix Paeoniae Alba: dispelling wind and heat pathogens, suppressing the hyperactive liver make eye bright, heat-clearing and toxic substances removing is ministerial drug; Contain volatile oil, chrysanthemum glycoside, adenine, choline, stachydrine, aminoacid etc., its preparation has coronary artery dilator, coronary blood flow increasing; Improve the effect of myocardial oxygen consumption, and have hypotensive effect.

Triangular: dispelling wind and heat pathogens, rash are antipruritic, improving acuity of vision and removing nebula, relieving convulsion are ministerial drug, contain a large amount of chitins, protein, aminoacid, organic acid etc., have anticonvulsant action.

Rhizoma Curcumae: promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing are ministerial drug, contain pachyman, pachymic acid, protein, fat, lecithin, choline etc., tool calmness, diuresis, increase myocardial contraction, hypoglycemic activity.

Radix Glycyrrhizae Preparata: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm are ministerial drug, contain volatile oil, flavonoid glycoside, nobiletin and vitamin B ₁, C etc., low dose of heart tonifying, increase cardiac output, coronary artery dilator, can the fortifying fibre protein dissolution, antithrombotic forms, and choleretic effect is arranged.

Therapeutic effect was obvious after most of patients was taken this Chinese medicine, illustrated (for the protection patients ' privacy, saving its name):

Name

Sex

Age

Consultation time

Treatment process

Symptom

The situation of taking medicine

The temperature certain

The man

38 years old

In October, 2003

Suffer from chronic hepatitis B, with occurring leukopenia February behind the interferon therapy, hospital treatment once, more back recurrence

The PBL counting continues to be lower than normal value 4 * 10 9/ L accompanies weak

Once took the leucogen, recovery from illness back recurrence is obeyed behind 21 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in 2 years

Hao

The man

43

In JIUYUE, 2000

Suffer from chronic hepatitis B and caused leukopenia 1 year, once hospital treatment recurred after healing

The PBL counting continues to be lower than normal value 4 * 10 9/ L accompanies weak, happiness lazy moving for sleeping in

Once took leucogen, batilol, recovery from illness back recurrence is obeyed behind 60 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in 2 years

Lee

The man

49

In June, 2002

Suffer from chronic hepatitis B and cause leukopenia August, hospital treatment once, more back recurrence

The PBL counting continues to be lower than normal value 4 * 10 9/ L does not have uncomfortable

Once took the leucogen, recovery from illness back recurrence is obeyed behind 30 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in 2 years

Grandson

The woman

36

In March, 2005

Suffer from chronic hepatitis B, with occurring leukopenia June behind the interferon therapy, hospital treatment once, more back recurrence

The PBL counting continues to be lower than normal value 4 * 10 9/ L accompanies weak

Once took leucogen, DIYU SHENGBAI PIAN, recovery from illness back recurrence is obeyed behind 30 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in 2 years

Chen

The woman

33

In November, 2004

Suffer from chronic hepatitis B, with occurring leukopenia March behind the interferon therapy, hospital treatment once, more back recurrence

The PBL counting continues to be lower than normal value 4 * 10 9/ L accompanies weak

Once took leucogen, batilol, recovery from illness back recurrence is obeyed behind 24 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in 2 years

[0022]

Lu

The woman

45

In February, 2005

Suffer from chronic hepatitis B and caused leukopenia 13 months, once hospital treatment recurred after healing

The PBL counting continues to be lower than normal value 4 * 10 9/ L does not have uncomfortable

Once took leucogen, DIYU SHENGBAI PIAN, recovery from illness back recurrence is obeyed behind 45 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in 2 years

The Wang

The man

41

In April, 2006

Suffer from chronic hepatitis B, with occurring leukopenia March behind the interferon therapy, hospital treatment once, more back recurrence

The PBL counting continues to be lower than normal value 4 * 10 9/ L accompanies weak

Once took leucogen, DIYU SHENGBAI PIAN, recovery from illness back recurrence is obeyed behind 30 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in 2 years

Zhang

The man

39

In March, 2007

Suffer from chronic hepatitis B and cause leukopenia May, hospital treatment once, more back recurrence

The PBL counting continues to be lower than normal value 4 * 10 9/ L accompanies weak

Once took the leucogen, more back recurrence of convulsion is obeyed behind 21 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in 2 years

Teng

The man

47

In February, 2007

Suffer from chronic hepatitis B and cause leukopenia March, hospital treatment once, more back recurrence

The PBL counting continues to be lower than normal value 4 * 10 9/ L does not have uncomfortable

Once took the leucogen, recovery from illness back recurrence is obeyed behind 21 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in 2 years

Cao

The man

33

In October, 2008

Suffer from chronic hepatitis B, with occurring leukopenia July behind the interferon therapy, hospital treatment once, more back recurrence

The PBL counting continues to be lower than normal value 4 * 10 9/ L, companion's poor appetite, weak, lazy moving

Once took leucogen, DIYU SHENGBAI PIAN, recovery from illness back recurrence is obeyed behind 45 doses in this Chinese medicine more, follows up a case by regular visits to not recurrence in a year

The specific embodiment:

Embodiment 1: to make pill is example, gets the Radix Astragali 20 grams, Radix Angelicae Sinensis 7 grams, Radix Codonopsis 12 grams, Radix Rehmanniae Preparata 12 grams, the Radix Paeoniae Alba 12 grams, triangular 12 grams, Rhizoma Curcumae 12 grams, Radix Glycyrrhizae Preparata 3 grams; At first above-mentioned raw material is mixed, clean up; Again cleaned raw material is put into drying baker and dry, grind to form graininess then, reuse 100 purpose sieves sieve ground raw material, and the medicine that granule is little filters out, and for future use, grinding into powder again that granule is big sieved; Then 90 gram Mel are put into pot with the low baking temperature refining, coagulate like the maltosemalt sugar shape, the not order of stirring is burnt; At last refined honey is mixed with above-mentioned medicamental pulverata and rubs by evenly, place half an hour approximately, rub once more by, the honeyed pill of processing about 6 grams gets final product;

Embodiment 2: to make the medicamental pulverata electuary is example, gets the Radix Astragali 28 grams, Radix Angelicae Sinensis 8 grams, Radix Codonopsis 10 grams, Radix Rehmanniae Preparata 10 grams, the Radix Paeoniae Alba 11 grams, triangular 11 grams, Rhizoma Curcumae 11 grams, Radix Glycyrrhizae Preparata 4 grams; At first above-mentioned raw material is mixed, clean up; Again cleaned raw material is put into drying baker and dry, grind to form graininess then, reuse 100 purpose sieves sieve ground raw material; The medicine that granule is little filters out; For future use, grinding into powder again that granule is big sieved, and is that the unit pack gets final product with 6 grams at last;

Embodiment 3: to make capsule is example, gets the Radix Astragali 30 grams, Radix Angelicae Sinensis 8 grams, Radix Codonopsis 10 grams, Radix Rehmanniae Preparata 10 grams, the Radix Paeoniae Alba 10 grams, triangular 10 grams, Rhizoma Curcumae 10 grams, Radix Glycyrrhizae Preparata 5 grams; At first above-mentioned raw material is mixed, clean up; Again cleaned raw material is put into drying baker and dry, grind to form graininess then, reuse 100 purpose sieves sieve ground raw material; The medicine that granule is little filters out; For future use, grinding into powder again that granule is big sieved, and incapsulates with 0.5 gram at last to get final product.

Claims (2)

1. treat chronic hepatitis B or suffer from chronic hepatitis B for one kind, it is characterized in that it is grouped into by following one-tenth: Radix Astragali 20-30g, Radix Angelicae Sinensis 6-10g, triangular 8-12g, Rhizoma Curcumae 8-12g, Radix Rehmanniae Preparata 8-12g, Radix Paeoniae Alba 8-12g, Radix Codonopsis 8-12g, Radix Glycyrrhizae Preparata 3-5g with the leukopenic medicine due to the interferon therapy.

2. treat chronic hepatitis B or suffer from the method for preparing of chronic hepatitis B for one kind, it is characterized in that may further comprise the steps with the leukopenic medicine due to the interferon therapy:

1) cleans: raw material Radix Astragali 20-30g, Radix Angelicae Sinensis 6-10g, triangular 8-12g, Rhizoma Curcumae 8-12g, Radix Rehmanniae Preparata 8-12g, Radix Paeoniae Alba 8-12g, Radix Codonopsis 8-12g, Radix Glycyrrhizae Preparata 3-5g are mixed, clean up with clear water;

2) sieve: cleaned raw material is put into drying baker dry, grind into powder then, reuse 100 purpose sieves sieve raw material, and the medicamental pulverata that granule is little filters out, and for future use, grinding into powder again that granule is big sieved;

3) refining Mel: Mel is put into pot with the low baking temperature refining, coagulate like the maltosemalt sugar shape, the not order of stirring is burnt, and the addition of Mel is 1 times of raw-material weight;

4) process pill: the Mel of refining is mixed with above-mentioned medicamental pulverata rubs by evenly, placement half an hour, rub once more by, the honeyed pill of processing 6g gets final product.