CN104906244B - A kind of Chinese medicine composition for treating leukopenia - Google Patents
A kind of Chinese medicine composition for treating leukopenia Download PDFInfo
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- CN104906244B CN104906244B CN201510378956.XA CN201510378956A CN104906244B CN 104906244 B CN104906244 B CN 104906244B CN 201510378956 A CN201510378956 A CN 201510378956A CN 104906244 B CN104906244 B CN 104906244B
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating leukopenia, and it includes Radix Astragali 30g, Radix Angelicae Sinensis 30g, red ginseng 30g, Radix Codonopsis 30g, five tastes 20g and wether neck 100g.Said composition is used to treat the leukopenia caused by a variety of causes, efficient up to 90%.Especially with Neuroleptic Leukocytopenia positive effect caused by chemicotherapy.
Description
Technical field
The invention belongs to tcm field, and in particular to a kind of Chinese medicine composition for treating leukopenia.
Background technology
Leukopenia and (or) agranulocytosis originator (reason is failed to understand) are rare, mostly Secondary cases.Common
Pathogenesis is：Granulocyte hypoplasia, such as infection, ionising radiation, antitumor or other drugs influence；The ripe barrier of granulocyte
Hinder, see megaloblastic anemia, hinder again, myelodysplastic syndrome etc.；Granulocyte life span shortens, as spleen is high, infects, scorching
Disease or some drugses effect；Granulocyte abnormal distribution, the granulocyte in circulatory pool are migrated to marginal pool, granulocyte count and reduced,
After injecting adrenal hormone, granulocyte enters circulatory pool from marginal pool, counts and recovers normal, such a situation and allergy, viral blood
The factors such as disease, haemolysis and hemodynamic responses are relevant.
Leukopenia disease refers to that peripheral white blood cells counts one group of symptom caused by continuous decrease.Typical performance is head
It is dizzy, weak, limbs are aching and limp, anorexia, One's spirits are drooping, low-heat, insomnia, sphagitis and mucosa ulcer etc..It is " empty to belong to motherland's medical science
Labor " category.Chinese traditional treatment leukopenia uses nourishing qi and blood, tonifying kidney and benefiting sperm, all method preventions of strengthening spleen and nourishing stomach.Western medical treatment is more
Give preventing and treating infection, hormone, adenine phosphate, batyl alcohol, leucogen, Ampeptide Elemente etc..What is be in a bad way gives hematopoiesis stimulating factors, arrives
The curative effect of medication of these increasing leucocytes is all temporary transient so far, as the cause of disease does not remove or reason is failed to understand, can only play temporarily
Mitigation, therefore be typically chosen 1-2 kind leucocyte increasing agents, observe 3-4 weeks, other group of medicine is used instead Ru invalid,
In expensive and effective a period of time, it is not basic treatment method though hematopoiesis stimulating factors blood transfusion is quick.This disease of Chinese traditional treatment,
Purpose that is integrally-regulated, therefore can fundamentally reaching healing is laid particular emphasis on, the traditional Chinese medical science thinks that this sick initial stage is mostly that qi-blood deficiency temper is lost
Based on damage, late period injures liver kidney, causes kidney-yin deficiency, kidney-yang deficiency or yin-yang deficiency, always with taste liver kidney deficiency damage for this.It is clinical to mend
Spleen and tonifying kidney, the methods of invigorating Qi and tonifying kidney is invigorated blood circulation, treat Neuroleptic Leukocytopenia, can take effect within general 1-2 weeks, and lasting medicine, invariably
The advantages of good reaction and side effect, by clinical and experimental study, some Chinese medicines have the function that obvious rise carries leucocyte.Such as
Radix Codonopsis, the Radix Astragali, giant knotweed, madder, dried human placenta, naze, stone reed, cornu cerve degelatinatum, fruit of Chinese magnoliavine etc..From these medicines, with reference to the traditional Chinese medical science
Dialectical, the leukopenia for treating blood disease, Neuroleptic Leukocytopenia and a variety of causes caused by tumor radiotherapy are failed to understand white
Leukopenia, it is obviously improved leucocyte effect.
The content of the invention
Object of the present invention is to provide a kind of Chinese medicine composition for treating leukopenia include the Radix Astragali, Radix Angelicae Sinensis,
Red ginseng, Radix Codonopsis, fruit of Chinese magnoliavine etc., the Chinese medicine composition are applicable the treatment of the leukopenia caused by a variety of causes, especially pin
Treatment to leukopenia caused by chemicotherapy is especially effective.
To realize the purpose of the present invention, there is provided following embodiment.
In a kind of Chinese medicine composition for treating leukopenia, it includes Radix Astragali 20-30 parts, Radix Angelicae Sinensis 30-40 parts, red ginseng
20-30 parts, Radix Codonopsis 30-40 parts, five tastes 10-20g parts and wether neck 80-120 parts.
In a preferable embodiment, Chinese medicine composition of the invention, it includes 30 parts of the Radix Astragali, 30 parts of Radix Angelicae Sinensis, red ginseng 30
100 parts of part, 30 parts of Radix Codonopsis, five tastes 20g parts and wether neck.
In one embodiment, a kind of Chinese medicine composition for treating leukopenia of the invention, by Radix Astragali 20-
30g, Radix Angelicae Sinensis 30-40g, red ginseng 20-30g, Radix Codonopsis 30-40g, fruit of Chinese magnoliavine 10-20g and wether neck 80-120g or they carry
Thing is taken to form.
In the above-described embodiment, it is preferred that Chinese medicine composition of the invention, by Radix Astragali 30g, Radix Angelicae Sinensis 30g, red ginseng 30g,
Radix Codonopsis 30g, fruit of Chinese magnoliavine 20g and wether neck 100g or their extract composition.
In another embodiment, there is provided a kind of method for the Chinese medicine composition for preparing the present invention, comprise the following steps：
1) wether neck is added into boiling boiling, removes oil bloom；
2) Radix Astragali, Radix Angelicae Sinensis, red ginseng, Radix Codonopsis, the fruit of Chinese magnoliavine is added to decoct；
3) optionally, filtering, take filtrate.
In another embodiment, a kind of method for the Chinese medicine composition for preparing the present invention, comprises the following steps：
1) wether neck 80-120g is added in 2000-4000ml water and boiled, remove oil bloom；
2) add Radix Astragali 20-30g, Radix Angelicae Sinensis 30-40g, red ginseng 20-30g, Radix Codonopsis 30-40g, fruit of Chinese magnoliavine 10-20g to decoct, directly
It is 600ml or lower (such as 300ml) to remaining water；
3) optionally, filtering, take filtrate.
Preferably, in above-mentioned another specific embodiment, method of the invention, the dosage for walking poly- 1) reclaimed water is
3000ml, wether neck 100g；In step 2), Radix Astragali 30g, Radix Angelicae Sinensis 30g, red ginseng 30g, Radix Codonopsis 30g, fruit of Chinese magnoliavine 20g.
In above-mentioned another specific embodiment, the decoction in the step 2), once, twice or more times can be decocted, closed
And decoction liquor, 600ml or lower is further concentrated to, such as 300ml.It is oral directly to patient, respectively take for 2 times, once in the morning and once at night.
Optional, in above-mentioned another specific embodiment, method of the invention, being further condensed into filtered fluid will soak
Cream, then by extract dry into particle.Particle is loaded into capsule, or adds auxiliary material and the Chinese patent medicine preparations such as tablet, pill is made.Or will
Oral liquid is made in filtrate.
The Chinese medicine composition of the present invention is used to treat the leukopenia caused by a variety of causes, and particularly chemicotherapy is drawn
The treatment of the leukopenia risen is especially effective.Instructions of taking, the Chinese medicine composition of each pair (i.e. each prescription) present invention,
Decoct into the decoction less than or equal to 600ml, preferably 300ml, respectively 2 times it is oral, once in the morning and once at night, each 300ml is (or preferably
150ml)。
It is white caused by the leukopenia of leukopenia of the present invention including cancer caused by radiation, blood disease
Leukopenia caused by cytopenia or other reasons.
The Chinese medicine composition of the treatment leukopenia of the present invention, side's solution are as follows：
The Radix Astragali：The medicinal of the Radix Astragali has the history of more than 2000 years so far, its have enhancing body's immunity, liver protection, diuresis,
Anti-aging, resisting stress, decompression and wide antibacterial action modern medicine study show, the Radix Astragali have enhancing body's immunity,
Liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial action.
Radix Angelicae Sinensis：Its root of Radix Angelicae Sinensis can be used as medicine, and be one of the most frequently used Chinese medicine.With enriching blood and invigorating blood circulation, menstruction regulating and pain relieving, cunning is moisturized
Intestines, anticancer, anti-ageing the effect of preventing always, be immune.Radix Angelicae Sinensis and its extract sodium ferulate and Radix Angelicae Sinensis polysaccharide are to monocytes/macrophages system
System has obvious stimulation, also has immune regulation and restitution to the body of immunologic hypofunction.Radix Angelicae Sinensis is to Healthy People
Lymphocyte transformation also has facilitation.Radix Angelicae Sinensis be the traditional Chinese medical science enrich blood, key medicine of invigorating blood circulation.Experimental study proves that Radix Angelicae Sinensis polysaccharide can increase
Peripheral red blood cells, leucocyte, hemoglobin and bonemarrow nucleated cells number, it is this effect particularly peripheral blood cells reduce and
It is particularly evident when marrow is suppressed.
Red ginseng：Red ginseng can improve brain, physical work capacity and immunologic function, enhancing, antifatigue, antitumor, anti-aging, resist
Radiation, Yixinfumai, calm the nerves promote the production of body fluid, tonifying lung invigorating the spleen.
Radix Codonopsis：Radix Codonopsis is mild-natured, sweet, has tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung, anticancer, decompression, anti anoxia, the work(of anti-aging
Effect, can also strengthen body immunity, improve the activity of superoxide dismutase, and enhancing eliminates the ability of free radical, has and adjusts
Save gastrointestinal motility, antiulcer, gastric acid secretion inhibiting, the effect for reducing pepsin activity.Suitable for spleen and lung weakness, the shortness of breath heart
Throb with fear, the disease such as anorexia and loose stool, ulcer, anaemia, virtual asthma cough, Heat Diabetes.
The fruit of Chinese magnoliavine：Astringe the lung, nourshing kidney, promote the production of body fluid, receive sweat, puckery essence.Control the deficiency syndrome of the lung to breath with cough, thirst, spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin
It is thin, emission, protracted dysentery and diarrhea.Influence to immunologic function：Defence capability of the body to nonspecific stimulation can be strengthened.
Wether neck：The Hui ethnic group people are kind to cook, and happiness essence cooks food, there is unique custom of this nationality, various wind on diet
The unique flavor of taste snack.And some " recipe " " congee spectrum " " tea spectrums " are exactly good health food, there is obvious rich in nutrition, be good for
Spleen appetizing, kidney-replenishing sperm-supplementing effect.
Specific preparation method：1 point of 5 decile of wether neck, take to boil in 1 part (about 100g) addition 3000ml water and deoil
Flower, it is put into Radix Astragali 30g, Radix Angelicae Sinensis 30g, red ginseng 30g, Radix Codonopsis 30g, fruit of Chinese magnoliavine 20g, endures to 600ml or 300ml, sooner or later each 300ml
Or 150ml, the course for the treatment of 5 days.Wether neck meat stew it is rotten take in the lump it is better.Also can be condensed into according to Chinese medicinal preparation method orally
Liquid or soft capsule, it is easy to take.Up to a hundred Neuroleptic Leukocytopenia patients are treated using the Chinese medicine preparation (Chinese medicine composition) of the present invention,
Toxicity is small, safe, efficient up to 90%.
Embodiment
Following examples are used for the essence for understanding the present invention, but do not limit the scope of the present invention with this.
Embodiment 1 treats the Traditional Chinese medicine composition formula of leukopenia：
Radix Astragali 30g, Radix Angelicae Sinensis 30g, red ginseng 30g, Radix Codonopsis 30g, fruit of Chinese magnoliavine 20g, wether neck 100g.
Preparation method, wether neck 100g, which is added in 3000ml water, boils oil bloom, is put into Radix Astragali 30g, Radix Angelicae Sinensis 30g, red
Join 30g, Radix Codonopsis 30g, fruit of Chinese magnoliavine 20g, endure to 300ml decoctions, or filtering liquid medicine, take filtrate.
Instructions of taking：Neuroleptic Leukocytopenia patient, the decoction after filtering that once a dose sooner or later, each 150ml.It is or not used
Filter, wether neck meat is taken together with decoction of medicinal ingredients, better.
Embodiment 2 treats the Traditional Chinese medicine composition formula of leukopenia：
Radix Astragali 20g, Radix Angelicae Sinensis 30g, red ginseng 20g, Radix Codonopsis 30g, fruit of Chinese magnoliavine 10g, wether neck 120g.
Preparation method, wether neck 120g, which is added in 3000ml water, boils oil bloom, be put into the Radix Astragali of recipe quantity, Radix Angelicae Sinensis,
Red ginseng, Radix Codonopsis, the fruit of Chinese magnoliavine, endure to 600ml decoctions, or filtering liquid medicine, take filtrate.
Instructions of taking：Chemicotherapy Neuroleptic Leukocytopenia patient, the decoction after once a dose decoction or filtering sooner or later, every time
200ml。
Embodiment 3 treats the Traditional Chinese medicine composition formula of leukopenia：
Radix Astragali 30g, Radix Angelicae Sinensis 40g, red ginseng 30g, Radix Codonopsis 40g, fruit of Chinese magnoliavine 20g, wether neck 80g.
Preparation method, wether neck 80g, which is added in 3000ml water, boils oil bloom, is put into the Radix Astragali of recipe quantity, Radix Angelicae Sinensis, red
Ginseng, Radix Codonopsis, the fruit of Chinese magnoliavine, endure to 300ml decoctions, or further filter to take filtrate, heating is condensed into medicinal extract, dry, pulverize particle
Or fine powder, it is fitted into capsule.
Instructions of taking：Chemicotherapy Neuroleptic Leukocytopenia patient, divide 2 times and take, once a dose sooner or later, each taking 150ml medicines
Liquid or the capsule equivalent to 150ml decoctions.
Clinical test
The people of Neuroleptic Leukocytopenia patient 162, degree classification is reduced by leucocyte：1 degree of 90 people, 2 degree of 48 people, 3 degree of 16 people, 4 degree 8
People, wherein, it is the Neuroleptic Leukocytopenia as caused by chemicotherapy to have 20 patients.Using the decoction of the Chinese medicine composition of embodiment 1, give
Patient is oral, treatment course 5-10 days.
Evaluate curative effect index and evaluation result：
It is effective：Subjective symptoms disappears or basic disappearance, total white blood cells rise 50%, or 2001-3000/mm3, sum reaches
4000/mm3More than.
Effectively：Subjective symptoms improves, and total white blood cells rises 40%, or 501-2000/mm3, it is total not reach 4000/mm3With
On.
It is invalid：Subjective symptoms does not improve or temporarily has improvement, and total white blood cells rises 30%, or sum is in 500/mm3With
Under.
Result of the test such as table 1 below：
The clinical test results of table 1
Shown by upper table result, Chinese medicine composition of the invention, the effective percentage to 1-2 degree leukopenia patients is
100%, 87.5% and 75% are respectively reached to the effective percentage of 3-4 degree leukopenia patients.Total effective rate is 97.5%.It is special
It is not that it is chemoradiotherapy patient to have 20 people in all experiment patients, entirely reaches effective effect.
Embodiment 2-3 Chinese medicine composition also generates essentially identical clinical treatment after leukopenia patient takes
Effect.
The Chinese medicine composition of the present invention, the simple plus-minus that those skilled in the art is carried out under the Spirit Essence of the present invention
Or modification, fall within the scope of the present invention.
Claims (5)
- A kind of 1. Chinese medicine composition for treating leukopenia, by Radix Astragali 20-30g, Radix Angelicae Sinensis 30-40g, red ginseng 20-30g, party Join 30-40g, fruit of Chinese magnoliavine 10-20g and wether neck 80-120g or their extract composition, the composition is by following methods It is made, this method comprises the following steps：1) wether neck is added into boiling boiling, removes oil bloom；2) Radix Astragali, Radix Angelicae Sinensis, red ginseng, Radix Codonopsis, the fruit of Chinese magnoliavine is added to decoct；3) optionally, filtering, filtrate is taken,Wherein, the dosage of water corresponding to each prescription is 2000-4000ml, and decocting time is decocts decoction to 600ml or more It is low.
- 2. Chinese medicine composition as claimed in claim 1, by Radix Astragali 30g, Radix Angelicae Sinensis 30g, red ginseng 30g, Radix Codonopsis 30g, fruit of Chinese magnoliavine 20g With wether neck 100g or their extract composition.
- 3. Chinese medicine composition as claimed in claim 1, the dosage of water is 3000ml.
- 4. Chinese medicine composition as claimed in claim 1, decocting time is to decoct decoction to 300ml.
- 5. the Chinese medicine composition described in claim 1, the leucocyte that the leukopenia includes cancer caused by radiation subtracts Leukopenia caused by leukopenia caused by few disease, blood disease or other reasons.
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| CN102166329A (en) * | 2010-03-17 | 2011-08-31 | 慕少英 | Medicine for treating leukopenia caused by chronic hepatitis B or interferon and preparation method thereof |
| CN104161962A (en) * | 2014-07-18 | 2014-11-26 | 安徽省霍山县医院 | Cold prevention and treatment medicine |
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Patent Citations (7)
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|---|---|---|---|---|
| CN1067816A (en) * | 1991-12-17 | 1993-01-13 | 张兆旺 | Making method of vital energy and blood tonifying medicine |
| CN1107338A (en) * | 1994-02-23 | 1995-08-30 | 马水旺 | Medical liquor for bathing |
| CN1965951A (en) * | 2005-11-17 | 2007-05-23 | 大连天山药业有限公司 | Blood tonic capsule having ass hide and method for preparing same |
| CN101695537A (en) * | 2009-09-15 | 2010-04-21 | 哈药集团三精制药股份有限公司 | Hematogenesis recovery oral liquid and preparation method thereof |
| CN101757249A (en) * | 2009-11-27 | 2010-06-30 | 赵德润 | Ejiao Eling paste |
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