CN1067816A - Making method of vital energy and blood tonifying medicine - Google Patents
Making method of vital energy and blood tonifying medicine Download PDFInfo
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- CN1067816A CN1067816A CN 91107958 CN91107958A CN1067816A CN 1067816 A CN1067816 A CN 1067816A CN 91107958 CN91107958 CN 91107958 CN 91107958 A CN91107958 A CN 91107958A CN 1067816 A CN1067816 A CN 1067816A
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Abstract
Making Method of vital energy and blood tonifying medicine belongs to medical production technical field.
The invention provides a kind of preparation method with herbal mixture instant effervescent particles of qi and blood tonifying function.This method is made product can treat or prevent multiple diseases such as anemia, leukopenia, and sour-sweet tasty and refreshing, has the soda pop local flavor.Preparation method of the present invention is to make dried cream after Chinese medicine astragalus, Radix Codonopsis, Radix Angelicae Sinensis, Fructus Lycii, Fructus Crataegi are extracted respectively; Get the dried cream of Fructus Lycii, Fructus Crataegi and Radix Angelicae Sinensis, adjuvants such as adding acidic flavoring agent are made granule A; Get Radix Codonopsis, the dried cream of the Radix Astragali mixes with the Chinese medicine Colla Corii Asini, add adjuvant such as foaming agent and make granule B; After two kinds of granules of A and B are mixed promptly.
Description
The present invention is Chinese patent medicine preparation technology, belongs to medical production technical field.
Anemia is a class commonly encountered diseases of internal department, as Iron deficiency anemia in children, old hemopoietic function of bone marrow decline property anemia, endurance and the big athletic anemia of training burden, hemorrhagic anemia, the leukopenia that X-ray therapy causes, chemicals or drug induced leukopenia or the like all are the sickness rate disease with high.Mostly the medicine that is used for the treatment of this quasi-blood disease at present is with the chemicals to be the various medicaments of raw material, as contains iron preparation, contains folic acid, VB
12, VB
4In preparation, they are better to partial malnutrition anemia curative effect, and unsatisfactory to the anemia and the leukopenia curative effect of other types, and the course of treatment is longer, easily recurrence after the drug withdrawal, and curative effect is consolidated not as Chinese medicine.In Chinese medicinal formulae, the most famous with Radix Angelicae Sinensis decoction for tonifying blood, according to the Chinese medicine traditional theory, this side gets the source of the gas of Radix Astragali spleen reinforcing lung with abundant hemopoietic, more uses Radix Angelicae Sinensis benefit blood and battalion, so that Yin grows while yang is generating, the prosperous hemopoietic of gas.But this side is a traditional decoction, fry in shallow oil soup and take medicine and different be inconvenience, and mouthfeel is not good, and is not easy for patients to accept, especially do not welcome by the child.The regulate the flow of vital energy product of removing food stagnancy of this Fang Zhongwu are taken for a long time to have and are grown the greasy fraud that hinders stomach.Because we enrich blood and only depend on Radix Angelicae Sinensis, and do not have the in love product of flesh and blood, it is not enough that power is still disliked.Though the Radix Astragali can tonifying Qi and lifting yang, inspire healthy energy, if with the Radix Codonopsis compatibility, interdependent with QI invigorating reinforcement, the enriching blood and promoting secretion of body fluid of Radix Codonopsis be usefulness, as a means of the source of vital function, its benefit is cited.The traditional Chinese medical science is thought " kidney storing essence, smart give birth to marrow ", and deficiency of kidney-essence often anemia and so on disease can occur.This Fang Zhongru increases the thing of kidney nourishing and blood enriching, and then curative effect will be better.According to above-mentioned, ancient prescription Radix Angelicae Sinensis decoction for tonifying blood curative effect is still very dissatisfied, and therapeutic domain is also extensive inadequately, takes the anxiety that greasy diaphragm can be arranged for a long time.
Prescription of the present invention is reused the Radix Astragali and Radix Codonopsis, gets the sweet temperature of the Radix Astragali, tonifying Qi and lifting yang, and to inspire healthy energy, Radix Codonopsis is sweet flat, can the QI invigorating reinforcement, again can enriching blood and promoting secretion of body fluid, the Radix Astragali is apt to away the flesh table, Radix Codonopsis benefaction the five internal organs, the two is interdependent be usefulness, as a means of the source of vital function, its benefit is cited.Colla Corii Asini in the side is the in love product of flesh and blood, can tonifying liver blood, kidney nourishing water and lung moistening is dry for controlling the good merchantable brand of blood deficiency, with Radix Angelicae Sinensis 5 usefulness, blood nourishing function heightens.Fructus Lycii nourishing kidney spermatogenesis in the side, the merit of useful blood, Fructus Crataegi energy activating blood circulation to dissipate blood stasis, the removing food stagnancy of regulating the flow of vital energy both can prevent that tonic was obeyed greasy diaphragm for a long time among the we, and the effect of promoting flow of QI and blood is arranged again.
Product of the present invention is a kind of graininess that is, and it is quickly dissolving to add an amount of warm water when taking, and produces bubble, and the effervescence type electuary of sour-sweet tasty and refreshing sense is arranged; It has not only kept the effect of Radix Angelicae Sinensis decoction for tonifying blood, and has strengthened the vigorate qi and replenish the blood performance greatly, has enlarged range of application, has improved curative effect, and overcome clothes of a specified duration greasy every shortcoming.It is easy to store transportation, and dosage is accurate during use, takes good mouthfeel, easily is patient, especially child's welcome, is the unique good dosage form that occurs first in the compound Chinese patent medicine.
According to examination department of Patent Office of the People's Republic of China search report, did not influence novelty document of the present invention by retrieval.(retrieval service is entrusted numbering 91716)
The object of the present invention is to provide a kind of is primary raw material with Chinese medicine, has the preparation method of the Method of vital energy and blood tonifying medicine of vigorate qi and replenish the blood effect.Method of vital energy and blood tonifying medicine is the solid particle agent, and dosage is accurate, and sour and sweet palatability is easy to use, and is beneficial to batch process, packing, stores and transports.It is solubilized that this electuary adds an amount of eliminating cold for resuscitation water in use, and produces bubble and be the effervescent shape, so the title Method of vital energy and blood tonifying medicine.This electuary can treat various anemias and the deficiency of vital energy weak, the overstrain internal injury, blood deficiency and yellow complexion, anorexia and loose stool, dizzy cardiopalmus, interior-heat is quenched one's thirst, spitting of blood, haematemesis, hematuria, have blood in stool, disease such as metrorrhagia and leukopenia.Because this product toxicity is humble, can take for a long time again, so also can be used as the usefulness of giving anti-anemia or nourishing the body.
Preparation method of the present invention is:
1, prescription is formed: the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Colla Corii Asini, Fructus Crataegi, Fructus Lycii, foaming agent, acidic flavoring agent, sweeting agent, binding agent, flavouring agent.
2, preparation method:
One, respectively Chinese medicine Fructus Lycii, Fructus Crataegi are flattened fragmentation, extract (also available cooking process extracts) with suitable solvent immersion, percolation and collect extracting solution, the recovery solvent is evaporated to the thick paste shape again, gets dry extract through drying under reduced pressure, and this is acid dried cream.
Two, respectively Chinese medicine astragalus, Radix Codonopsis, Radix Angelicae Sinensis are extracted for several times (also available percolation extracts) with suitable solvent steaming and decocting, merge extractive liquid,, filter, add high concentration ethanol after the filtrate evaporation and concentration, make that determining alcohol reaches 65% in the concentrate, leave standstill after-filtration, filtrate decompression concentrates, drying obtains the dried cream of the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis respectively, and this is neutral dried cream.
Three, get a kind of in acid dried cream and the dried cream of Radix Angelicae Sinensis or other the neutral dried cream, mix the back and add acidic flavoring agent, sweeting agent, mixed powder is broken into fine powder, makes soft material with debita spissitudo ethanol, granulates, and the dry back of a wet grain granulate promptly gets dried granule A.
Four, get all the other neutral dried cream and mix with Colla Corii Asini, add foaming agent, sweeting agent, mixed powder is broken into fine powder, makes soft material with the ethanol of debita spissitudo, granulates, and the dry back of wet grain granulate promptly gets dried granule B.
Five, with dried granule A and B mixing in proportion, spray into an amount of flavouring agent, seal packing after 12 hours.Also can utilize the fragrance of medicine own, not add flavouring agent and directly pack.
Six, the product that above-mentioned steps is made carries out quality testing, should meet: the pertinent regulations of an appendix electuary general rule of (1) " Chinese Pharmacopoeia nineteen ninety version ".(2) Ministry of Public Health is about the pertinent regulations of Chinese patent medicine sanitary standard.(3) measure total nitrogen with Kjeldahl method, nitrogen content must not be lower than 1%.(4) measure 45% ethanol soluble extraction with cold-maceration (methods of " Chinese Pharmacopoeia nineteen ninety version " 47 pages of regulations of appendix), extract content must not be less than 83%, (5) measure ethyl acetate one dehydrated alcohol (2: 1) extractum with above-mentioned cold-maceration, extract content must not be less than 3%.
Seven, above-mentioned steps is made product, carry out acute toxicity test, the result finds no acute toxic reaction.Carrying out long term toxicity test shows: be converted into rat and rabbit dose,equivalent 8 times with the adult treatment amount, gastric infusion is 180 days continuously, with matched group relatively, do not see toxic reaction.
3, explanation:
One, listed foaming agent means the inorganic carbonate that sodium carbonate, sodium bicarbonate or other can be edible in the prescription.
Two, the prescription in listed acidic flavoring agent mean can be edible organic acid, as lactic acid, gluconic acid, tartaric acid, malic acid, citric acid.
Three, the prescription in listed sweeting agent mean can be edible sweeting agent, as white sugar, maltose, glucose, stevioside, glucide, aspartame, glycyrrhizin.
Four, listed binding agent means the binding agent that dextrin, cyclodextrin or other can be edible in the prescription.
Five, solvent described in the preparation method means water, ethanol or other lower aliphatic alcohols.
The present invention has following advantage compared with the prior art:
1, Method of vital energy and blood tonifying medicine of the present invention has changed the dosage form of traditional Radix Angelicae Sinensis decoction for tonifying blood.This electuary is easy to use, and dosage is accurate, and is sour-sweet tasty and refreshing when taking, and easily accepted by the patient, especially is fit to children taking.
2, Method of vital energy and blood tonifying medicine of the present invention has enlarged the Radix Angelicae Sinensis decoction for tonifying blood clinical application range, has improved curative effect, has reduced side effect.
3, Method of vital energy and blood tonifying medicine of the present invention is convenient to extensive manufacturing, and the quality control strictness can guarantee curative effect.
4, Method of vital energy and blood tonifying medicine of the present invention is a kind of solid drying granule, be easy to packing, store and transportation, and also not perishable.
Add eliminating cold for resuscitation water when 5, Method of vital energy and blood tonifying medicine of the present invention is taken and dissolve the formation decoction, not only preserved all advantages of decoction, and residual traces of carbon dioxide is of value to gastrointestinal function in the solution.
6, Method of vital energy and blood tonifying medicine of the present invention has the clear and definite regulation of quality testing reliably, can control and guarantee product quality.
7, toxicological test shows that Method of vital energy and blood tonifying medicine is nontoxic, can take for a long time, and this chronic patients to the palpus long-term prescription is very favourable beyond doubt.
8, Method of vital energy and blood tonifying medicine can be used as the tonic use, and has the soda pop local flavor, is a kind of good Chinese medicinal drink to the needs person of nourishing the body.
Most preferred embodiment of the present invention:
1, the Radix Astragali 250 grams, Radix Codonopsis 250 grams, Radix Angelicae Sinensis 150 grams are added suitable quantity of water respectively and soak, decoct three times, merge three times decocting liquid, filter, filtrate is concentrated into 1 milliliter of concentrate and is equivalent to crude drug 1 gram, adding ethanol makes concentrate contain alcohol amount to reach 65%, the leaching clear liquid, behind the recovery ethanol, concentrating under reduced pressure, drying gets the Radix Astragali, Radix Codonopsis, the dried cream of Radix Angelicae Sinensis respectively.
2, Fructus Lycii 100 grams, Fructus Crataegi 150 are restrained the flattening fragmentation,, collect percolate with 8 times of amount 45% ethanol percolations, concentrating under reduced pressure behind the recovery ethanol, drying promptly gets dry extract.
3, with behind Fructus Lycii and the dried cream of Fructus Crataegi dry slice cream adding Radix Angelicae Sinensis, add an amount of citric acid, dextrin, white sugar again, mixed powder is broken into fine powder, makes soft material with ethanol, granulates, and behind the wet grain drying granulate, promptly gets dried granule A.
4, the Radix Astragali and the dried cream of Radix Codonopsis are added Colla Corii Asini 150 grams, add an amount of sodium bicarbonate, white sugar again, mix to pulverize and make fine powder,, granulate, behind the wet grain drying granulate, promptly get dried granule B with ethanol system soft material.
5, after being mixed in proportion, dried granule A and B pack, every bag 20 gram, and plastic-aluminum is packed.
Claims (9)
1, a kind of preparation method of Method of vital energy and blood tonifying medicine is characterized in that taking the following step:
Chinese medicine astragalus, Radix Codonopsis, Radix Angelicae Sinensis are extracted with solvent respectively, extracting solution through evaporation, concentrate, precipitation, filtration, concentrating under reduced pressure, drying, make three kinds of dried cream of neutrality.Other extracts with solvent after getting Chinese medicine Fructus Lycii, the fragmentation of Fructus Crataegi difference, and the extracting solution concentrating under reduced pressure is made acid dried cream after the drying.Then the dried cream of acidity and any neutral dried cream combination are added acidic flavoring agent, sweeting agent, binding agent are made granule A.All the other two kinds of dried cream of neutrality are mixed with the Chinese medicine Colla Corii Asini, add foaming agent, sweeting agent, binding agent again and make granule B.Get granule A and B and mix, spray into flavouring agent (or not adding flavouring agent) and make instant effervescent particles.
2,, it is characterized in that described solvent means water, ethanol or other lower aliphatic alcohols according to the described preparation method of claim 1.
3, according to the described preparation method of claim 1, it is characterized in that described sweeting agent mean can be edible sweeting agent, as white sugar, maltose, glucose, stevioside, glucide, aspartame, glycyrrhizin.
4,, it is characterized in that described acidic flavoring agent means food acids, as lactic acid, gluconic acid, tartaric acid, malic acid, citric acid according to the described preparation method of claim 1.
5,, it is characterized in that described foaming agent means the inorganic carbonate that sodium carbonate, sodium bicarbonate or other can be edible according to the described preparation method of claim 1.
6, according to the described preparation method of claim 1, it is characterized in that described flavouring agent means edible essence, as flavoring orange essence, Fructus Citri Limoniae essence, also can utilize the fragrance of medicine that this method is used itself and do not add flavouring agent in addition.
7,, it is characterized in that with Fructus Lycii, Fructus Crataegi, Radix Angelicae Sinensis combination with preparation granule A according to the described preparation method of claim 1; Make up with preparation granule B with the Radix Astragali, Radix Codonopsis, Colla Corii Asini.
8,, it is characterized in that various raw material optimal proportions are according to the described preparation method of claim 1:
15 parts in 15 parts of Colla Corii Asini of 25 parts of Radix Angelicae Sinensis of 25 parts of Radix Codonopsis of the Radix Astragali
10 parts of an amount of sweeting agents of foaming agent of 15 parts of Fructus Lycii of Fructus Crataegi are an amount of
An amount of flavouring agent of an amount of binding agent of acidic flavoring agent is an amount of
9,, it is characterized in that the dosage form that adopts instant effervescent particles to give birth to as QI and blood according to the described preparation method of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91107958 CN1067816A (en) | 1991-12-17 | 1991-12-17 | Making method of vital energy and blood tonifying medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91107958 CN1067816A (en) | 1991-12-17 | 1991-12-17 | Making method of vital energy and blood tonifying medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1067816A true CN1067816A (en) | 1993-01-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91107958 Pending CN1067816A (en) | 1991-12-17 | 1991-12-17 | Making method of vital energy and blood tonifying medicine |
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| Country | Link |
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| CN (1) | CN1067816A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047284C (en) * | 1993-07-24 | 1999-12-15 | 金春乐 | Medicine condiment for stewed meals and its preparation |
| CN1051931C (en) * | 1994-11-28 | 2000-05-03 | 曹柱 | Compound preparation for curing nutritional iron-deficiency anemia |
| CN102813742A (en) * | 2012-06-27 | 2012-12-12 | 陕西今正药业有限公司 | Natural medicinal and edible raw material for improving nutritional anemia and preparation method thereof |
| CN103110741A (en) * | 2012-12-22 | 2013-05-22 | 潘海燕 | Medicinal liquor for treating stomach illness |
| CN103585515A (en) * | 2013-10-23 | 2014-02-19 | 青岛华仁技术孵化器有限公司 | Effervescing agent medicament for treating children alimentary anemia |
| CN104906244A (en) * | 2015-07-02 | 2015-09-16 | 赵成茂 | Traditional Chinese medicine composition for treating leucopenia |
| CN105226960A (en) * | 2014-05-28 | 2016-01-06 | 台达电子企业管理（上海）有限公司 | Power model |
-
1991
- 1991-12-17 CN CN 91107958 patent/CN1067816A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047284C (en) * | 1993-07-24 | 1999-12-15 | 金春乐 | Medicine condiment for stewed meals and its preparation |
| CN1051931C (en) * | 1994-11-28 | 2000-05-03 | 曹柱 | Compound preparation for curing nutritional iron-deficiency anemia |
| CN102813742A (en) * | 2012-06-27 | 2012-12-12 | 陕西今正药业有限公司 | Natural medicinal and edible raw material for improving nutritional anemia and preparation method thereof |
| CN102813742B (en) * | 2012-06-27 | 2014-02-05 | 陕西今正药业有限公司 | Natural medicinal and edible raw material for improving nutritional anemia and preparation method thereof |
| CN103110741A (en) * | 2012-12-22 | 2013-05-22 | 潘海燕 | Medicinal liquor for treating stomach illness |
| CN103585515A (en) * | 2013-10-23 | 2014-02-19 | 青岛华仁技术孵化器有限公司 | Effervescing agent medicament for treating children alimentary anemia |
| CN105226960A (en) * | 2014-05-28 | 2016-01-06 | 台达电子企业管理（上海）有限公司 | Power model |
| CN104906244A (en) * | 2015-07-02 | 2015-09-16 | 赵成茂 | Traditional Chinese medicine composition for treating leucopenia |
| CN104906244B (en) * | 2015-07-02 | 2017-11-10 | 赵成茂 | A kind of Chinese medicine composition for treating leukopenia |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |