CN104906244A - Traditional Chinese medicine composition for treating leucopenia - Google Patents
Traditional Chinese medicine composition for treating leucopenia Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating leucopenia. The traditional Chinese medicine composition contains 30g of milkvetch root, 30g of Chinese angelica, 30g of red ginseng, 30g of codonopsis pilosula, 20g of Chinese magnoliavine fruit and 100g of wether neck. The composition is used for treating the leucopenia caused by various reasons, and the effective rate reaches 90%. The composition particularly has an obvious effect of treating the leucopenia caused by radiotherapy and chemotherapy.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of Chinese medicine composition for the treatment of leukopenia.
Background technology
Leukopenia and (or) granulocytopenia originator (agnogenio) rare, mostly be Secondary cases.Common pathogenesis is: granulocyte hypoplasia, as infection, ionizing radiation, antitumor or other drug impact; Granulocyte dysmaturity, sees megaloblastic anemia, aplastic anemia, myelodysplastic syndrome etc.; Granulocyte life span shortens, as high in spleen, infect, inflammation or some drugs effect; Granulocyte abnormal distribution, the granulocyte in circulatory pool migrates to marginal pool, and granulocyte count reduces, after injection adrenal hormone, granulocyte enters circulatory pool from marginal pool, and counting recovers normal, and the factors such as this kind of situation and allergy, viremia, haemolysis and hemodynamic responses are relevant.
Leukopenia disease refers to the one group symptom of peripheral white blood cells counting caused by continuous decrease.Typical performance be dizzy, weak, limbs are aching and limp, loss of appetite, lethargy, low grade fever, insomnia, pharyngolaryngitis and mucosa ulcer etc.Belong to motherland's medical science " asthenia " category.Chinese traditional treatment leukopenia adopts benefiting QI and nourishing blood, the kidney invigorating and essence nourishing, all method preventions of strengthening the spleen and nourishing the stomach.Western medical treatment gives control infection, hormone, adenine phosphate, batilol, leucogen, ampeptide elemente etc. more.What be in a bad way gives hematopoiesis stimulating factors, up to the present the curative effect of medication of these leukocyte increasings is all temporary transient, as the cause of disease is not removed or agnogenio, temporary transient mitigation can only be played, therefore general selection 1-2 kind leucocyte increasing agent, observe 3-4 week, other group medicines are used instead as invalid, though hematopoiesis stimulating factors blood transfusion instant effect, expensive and effective a period of time is not basic Therapeutic Method.Chinese traditional treatment primary disease, lays particular emphasis on integrally-regulated, therefore fundamentally can reach the object of healing, and the traditional Chinese medical science thinks that mostly the primary disease initial stage is that the loss of QI and blood deficiency temper is main, and late period injures Liver and kidney, causes deficiency of the kidney yin, insufficiency of kidney-YANG or deficiency of both YIN and YANG, and always deficient with taste Liver and kidney is this.Clinical in reinforcing spleen and kidney, vital energy benefiting and the kidney invigorating such as to be invigorated blood circulation at the method treatment leukopenia, and general 1-2 week can take effect, and lasting medicine, have no adverse reaction and the advantage of side effect, by clinical and experimentation, some Chinese medicine has the leukocytic effect of obvious ascending.As Radix Codonopsis, the Radix Astragali, Rhizoma Polygoni Cuspidati, Radix Rubiae, Placenta Hominis, Squama Manis, Folium Pyrrosiae, Cornu Cervi Degelatinatum, Fructus Schisandrae Chinensis etc.Select these medicines, in conjunction with Chinese medical discrimination, for the leukopenia for the treatment of hematopathy, the leukopenia that the leukopenia caused by tumor radiotherapy and a variety of causes are failed to understand, all has and obviously puies forward effect in increasing leukocyte.
Summary of the invention
A kind of Chinese medicine composition for the treatment of leukopenia has been the object of the present invention is to provide to comprise the Radix Astragali, Radix Angelicae Sinensis, Radix Ginseng Rubra, Radix Codonopsis, Fructus Schisandrae Chinensis etc., this Chinese medicine composition is suitable for the treatment of the leukopenia caused by a variety of causes, and the treatment of the leukopenia especially caused for chemicotherapy is effective especially.
For realizing object of the present invention, provide following embodiment.
At a kind of Chinese medicine composition for the treatment of leukopenia, it comprises Radix Astragali 20-30 part, Radix Angelicae Sinensis 30-40 part, Radix Ginseng Rubra 20-30 part, Radix Codonopsis 30-40 part, five tastes 10-20g part and wether neck 80-120 part.
In a preferred embodiment, Chinese medicine composition of the present invention, it comprises the Radix Astragali 30 parts, Radix Angelicae Sinensis 30 parts, Radix Ginseng Rubra 30 parts, Radix Codonopsis 30 parts, five tastes 20g part and 100 parts, wether neck.
In one embodiment, a kind of Chinese medicine composition for the treatment of leukopenia of the present invention, is made up of Radix Astragali 20-30g, Radix Angelicae Sinensis 30-40g, Radix Ginseng Rubra 20-30g, Radix Codonopsis 30-40g, Fructus Schisandrae Chinensis 10-20g and wether neck 80-120g or their extract.
In the above-described embodiment, preferably, Chinese medicine composition of the present invention, is made up of Radix Astragali 30g, Radix Angelicae Sinensis 30g, Radix Ginseng Rubra 30g, Radix Codonopsis 30g, Fructus Schisandrae Chinensis 20g and wether neck 100g or their extract.
In another embodiment, a kind of method preparing Chinese medicine composition of the present invention is provided, comprises the following steps:
1) wether neck is added water boil, removing oil bloom;
2) Radix Astragali, Radix Angelicae Sinensis, Radix Ginseng Rubra, Radix Codonopsis, Fructus Schisandrae Chinensis decoction is added;
3) optional, filter, get filtrate.
In another embodiment, a kind of method preparing Chinese medicine composition of the present invention, comprises the following steps:
1) wether neck 80-120g is added in 2000-4000ml water boil, removing oil bloom;
2) add Radix Astragali 20-30g, Radix Angelicae Sinensis 30-40g, Radix Ginseng Rubra 20-30g, Radix Codonopsis 30-40g, Fructus Schisandrae Chinensis 10-20g decoct, until the water yield of remainder is 600ml or lower (as 300ml);
3) optional, filter, get filtrate.
Preferably, in another specific embodiments above-mentioned, method of the present invention, step poly-1) in the consumption of water be 3000ml, wether neck 100g; Step 2) in, Radix Astragali 30g, Radix Angelicae Sinensis 30g, Radix Ginseng Rubra 30g, Radix Codonopsis 30g, Fructus Schisandrae Chinensis 20g.
In another specific embodiments above-mentioned, described step 2) in decoction, can be decocted once, twice or more times, merge decoction liquor, reconcentration to 600ml or lower, as 300ml.Oral directly to patient, divide equally 2 times and take, sooner or later respectively once.
Optional, in another specific embodiments above-mentioned, method of the present invention, is condensed into filtrate extractum further, then extract dry is become granule.Granule is incapsulated, or adds adjuvant and make the Chinese patent medicine preparation such as tablet, pill.Or filtrate is made oral liquid.
Chinese medicine composition of the present invention is used for the treatment of the leukopenia caused by a variety of causes, particularly effective especially to the treatment of the leukopenia that chemicotherapy causes.Instructions of taking, each pays (i.e. each prescription) Chinese medicine composition of the present invention, decocts into the medicinal liquid being less than or equal to 600ml, preferred 300ml, divide equally 2 times oral, sooner or later each once, each 300ml (or preferred 150ml).
The leukopenia that leukopenia of the present invention comprises the leukopenia of cancer caused by radiation, hematopathy causes or the leukopenia that other reason causes.
The Chinese medicine composition for the treatment of leukopenia of the present invention, side separates as follows:
The Radix Astragali: the history of medicinal existing more than 2000 year so far of the Radix Astragali, it has enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and more widely antibacterial action modern medicine study show, the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Radix Angelicae Sinensis: its root of Radix Angelicae Sinensis can be used as medicine is one of the most frequently used Chinese medicine.Have and enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, anticancer, anti-ageing anti-old, immune effect.Radix Angelicae Sinensis and extract sodium ferulate thereof and Radix Angelicae Sinensis polysaccharide have obvious stimulation to monocytes/macrophages system, also have immune regulation and restitution to the body of immunologic hypofunction.The lymphocyte transformation of Radix Angelicae Sinensis to Healthy People also has facilitation.Radix Angelicae Sinensis is that the traditional Chinese medical science is enriched blood, key medicine of invigorating blood circulation.Experimentation proves, Radix Angelicae Sinensis polysaccharide can increase peripheral red blood cells, leukocyte, hemoglobin and bonemarrow nucleated cells number, and this effect is particularly particularly evident when periphery cytopenia and bone marrow are suppressed.
Radix Ginseng Rubra: Radix Ginseng Rubra can improve brain, physical work capacity and immunologic function, enhancing, resisting fatigue, antitumor, defying age, radioprotective, the heartsupplementing and pulse restoring, calm the nerves promote the production of body fluid, tonifying the lung spleen invigorating.
Radix Codonopsis: Radix Codonopsis is put down, sweet in the mouth, there is effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, body immunity can also be strengthened, improve the activity of superoxide dismutase, strengthen the ability eliminating free radical, there is the effect of Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.Be applicable to deficiency of the spleen and lung, the cough of cardiopalmus of breathing hard, anorexia and loose stool, ulcer, anemia, dyspnea due to deficiency, interior-heat such as to quench one's thirst at the disease.
Fructus Schisandrae Chinensis: astringe the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Impact on immunologic function: energy enhancing body is to the defence capability of nonspecific stimulation.
Wether neck: the kind cooking of the Hui ethnic group people, happiness essence cooks food, diet has the uniqueness of this nationality be accustomed to, the unique local flavor of various local delicacies.And some " recipe " " medicated porridge spectrum " " tea spectrum " is exactly good health food, there are obvious rich in nutrition, spleen benefiting and stimulating the appetite, kidney-replenishing sperm-supplementing effect.
Concrete preparation method: wether neck 1 point of 5 decile, get 1 part (about 100g) to add in 3000ml water and boil the flower that deoils, put into Radix Astragali 30g, Radix Angelicae Sinensis 30g, Radix Ginseng Rubra 30g, Radix Codonopsis 30g, Fructus Schisandrae Chinensis 20g, endure to 600ml or 300ml, sooner or later each 300ml or 150ml, 5 days courses for the treatment of.It is better that the lower effect of rotten clothes in the lump stewed by wether neck meat.Also can be condensed into oral liquid or soft capsule according to Chinese medicinal preparation method, be convenient to take.Adopt Chinese medicine formula of the present invention (Chinese medicine composition) to treat routine leukopenia patient up to a hundred, toxicity is little, and safety is high, and effective percentage reaches 90%.
Detailed description of the invention
Following examples for understanding essence of the present invention, but do not limit the scope of the invention with this.
Embodiment 1 treats the Traditional Chinese medicine composition formula of leukopenia:
Radix Astragali 30g, Radix Angelicae Sinensis 30g, Radix Ginseng Rubra 30g, Radix Codonopsis 30g, Fructus Schisandrae Chinensis 20g, wether neck 100g.
Preparation method, wether neck 100g adds in 3000ml water and boils the flower that deoils, and puts into Radix Astragali 30g, Radix Angelicae Sinensis 30g, Radix Ginseng Rubra 30g, Radix Codonopsis 30g, Fructus Schisandrae Chinensis 20g, endures to 300ml medicinal liquid, or filtering liquid medicine, gets filtrate.
Instructions of taking: leukopenia patient, services once the medicinal liquid after filtration, each 150ml sooner or later.Maybe need not filter, taken together with decoction by wether neck meat, effect is better.
Embodiment 2 treats the Traditional Chinese medicine composition formula of leukopenia:
Radix Astragali 20g, Radix Angelicae Sinensis 30g, Radix Ginseng Rubra 20g, Radix Codonopsis 30g, Fructus Schisandrae Chinensis 10g, wether neck 120g.
Preparation method, wether neck 120g adds in 3000ml water and boils the flower that deoils, and puts into the Radix Astragali of recipe quantity, Radix Angelicae Sinensis, Radix Ginseng Rubra, Radix Codonopsis, Fructus Schisandrae Chinensis, endures to 600ml medicinal liquid, or filtering liquid medicine, gets filtrate.
Instructions of taking: chemicotherapy leukopenia patient, services once medicinal liquid or the medicinal liquid after filtering, each 200ml sooner or later.
Embodiment 3 treats the Traditional Chinese medicine composition formula of leukopenia:
Radix Astragali 30g, Radix Angelicae Sinensis 40g, Radix Ginseng Rubra 30g, Radix Codonopsis 40g, Fructus Schisandrae Chinensis 20g, wether neck 80g.
Preparation method, wether neck 80g adds in 3000ml water and boils the flower that deoils, and puts into the Radix Astragali of recipe quantity, Radix Angelicae Sinensis, Radix Ginseng Rubra, Radix Codonopsis, Fructus Schisandrae Chinensis; endure to 300ml medicinal liquid, or further leaching filtrate excessively, heating is condensed into extractum; dry, pulverize granule or fine powder, in incapsulating.
Instructions of taking: chemicotherapy leukopenia patient, point takes for 2 times, sooner or later services once, each serving with 150ml medicinal liquid or the capsule being equivalent to 150ml medicinal liquid.
Clinical trial
Leukopenia patient 162 people, reduces degree classification by leukocyte: 1 degree of 90 people, 2 degree of 48 people, 3 degree of 16 people, 4 degree of 8 people, wherein, has 20 patients to be the leukopenia caused by chemicotherapy.Adopt the medicinal liquid of the Chinese medicine composition of embodiment 1, oral to patient, the treatment 5-10 days course for the treatment of.
Estimating curative effect index and evaluation result:
Effective: subjective symptoms disappears or substantially disappears, total white blood cells rises 50%, or 2001-3000/mm
3, sum reaches 4000/mm
3above.
Effective: subjective symptoms is improved, total white blood cells rises 40%, or 501-2000/mm
3, sum does not reach 4000/mm
3above.
Invalid: subjective symptoms is not improved or is temporarily improved, total white blood cells rises 30%, or sum is at 500/mm
3below.
Result of the test is as following table 1:
Table 1 clinical test results
Shown by upper table result, Chinese medicine composition of the present invention is 100% to the effective percentage of 1-2 degree leukopenia patient, reaches 87.5% and 75% respectively to the effective percentage of 3-4 degree leukopenia patient.Total effective rate is 97.5%.Particularly, in all test patients, there are 20 people to be chemoradiotherapy patients, all reach effective effect.
The Chinese medicine composition of embodiment 2-3 also creates substantially identical clinical efficacy after leukopenia patient takes.
Chinese medicine composition of the present invention, the simple plus-minus that those skilled in the art carries out under spirit of the present invention or modification, also belong to scope of the present invention.
Claims (10)
1. treat a Chinese medicine composition for leukopenia, it comprises Radix Astragali 20-30 part, Radix Angelicae Sinensis 30-40 part, Radix Ginseng Rubra 20-30 part, Radix Codonopsis 30-40 part, five tastes 10-20g part and wether neck 80-120 part.
2. Chinese medicine composition as claimed in claim 1, it comprises the Radix Astragali 30 parts, Radix Angelicae Sinensis 30 parts, Radix Ginseng Rubra 30 parts, Radix Codonopsis 30 parts, Fructus Schisandrae Chinensis 20 parts and 100 parts, wether neck.
3. treat a Chinese medicine composition for leukopenia, be made up of Radix Astragali 20-30g, Radix Angelicae Sinensis 30-40g, Radix Ginseng Rubra 20-30g, Radix Codonopsis 30-40g, Fructus Schisandrae Chinensis 10-20g and wether neck 80-120g or their extract.
4. Chinese medicine composition as claimed in claim 3, is made up of Radix Astragali 30g, Radix Angelicae Sinensis 30g, Radix Ginseng Rubra 30g, Radix Codonopsis 30g, Fructus Schisandrae Chinensis 20g and wether neck 100g or their extract.
5. prepare a method for the arbitrary described compositions of claim 1-4, comprise the following steps:
1) wether neck is added water boil, removing oil bloom;
2) Radix Astragali, Radix Angelicae Sinensis, Radix Ginseng Rubra, Radix Codonopsis, Fructus Schisandrae Chinensis decoction is added;
3) optional, filter, get filtrate.
6. method as claimed in claim 5, step poly-1) in, the consumption of the water that each prescription is corresponding is 2000-4000ml.
7. method as claimed in claim 6, the consumption of water is 3000ml.
8. method as claimed in claim 6, decocting time is decoct medicinal liquid to 600ml or lower.
9. method as claimed in claim 8, decocting time is decoct medicinal liquid to 300ml.
10. Chinese medicine composition according to claim 1, the leukopenia that described leukopenia comprises the leukopenia of cancer caused by radiation, hematopathy causes or the leukopenia that other reason causes.
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| CN112494579A (en) * | 2020-10-20 | 2021-03-16 | 东莞市名号奇花生物科技有限公司 | Anticancer traditional Chinese medicine formula for increasing leucocytes and improving immunity, decocting method and eating method |
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