CN102512593B

CN102512593B - Traditional Chinese medicine preparation for treating aplastic anemia

Info

Publication number: CN102512593B
Application number: CN 201110460080
Authority: CN
Inventors: 黄传峰
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-12-26
Filing date: 2011-12-26
Publication date: 2013-05-08
Anticipated expiration: 2031-12-26
Also published as: CN102512593A

Abstract

The invention discloses a traditional Chinese medicine preparation for treating aplastic anemia. The aplastic anemia can belong to the category of blood deficiency, blood depletion, consumptive disease and the like in the traditional Chinese medical science. Symptomatic treatment is adopted in the hospital, i.e. traditional Chinese medicines with effects of tonifying spleen and kidney, tonifying qi and nourishing blood are selected, such as Codonopsis pilosula, bighead atractylodes rhizome, Rhodiola rosea, Schisandra chinensis, Eucommia ulmoides, chaff flower root, wolfberry fruit, semen canavaliae, Semen sesami nigrum, sophora flower, rhizoma polygonati, semen cassiae and arillus longan, and the traditional Chinese medicines are prepared into a decoction for patients to take. Proved by clinical tests of the hospital, the total effective rate is 93.3 percent, and is obviously superior to that of a control group. Moreover, the traditional Chinese medicine preparation for treating the aplastic anemia does not have toxic and side effects after being taken for a long time, and is low in treatment cost.

Description

A kind of Chinese medicine preparation for the treatment of aplastic anemia

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of aplastic anemia.

Background technology

Chronic aplastic anemia is one group of marrow hematopoiesis function failure that is caused by Different types of etiopathogenises, and the intractable hematopathy take hematopoietic stem cell injuries, peripheral blood pancytopenia as feature often shows as anemia, hemorrhage and infect clinically; Usually lassitude, tired rear tachypnea, cardiopalmus, dizziness, pale complexion.If any hemorrhage also slighter, visceral hemorrhage is more rare.Infect, heating is generally slighter, occur more late, more easy to control after treatment.Liver, all not enlargements of splenic lymph nodes have the spleen silght enlargement but late case is even, and the course of disease is longer, and the patient can survive for many years, and the state of an illness takes a turn for the better gradually and even approaches recovery from illness.

The method of conventional therapy chronic aplastic anemia has a variety of, mainly contain operative treatment, adrenocortical hormone therapy, the operative treatment wound is larger, Long-term Hormone, as oral immunity inhibitor cyclosporin A etc., side effect is large, as liver function injury, edema, body weight increase, acne etc.Taking the Chinese medicine symptomatic treatment is a kind of effective method.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of aplastic anemia.Aplastic anemia can belong to the categories such as " blood deficiency ", " blood depletion ", " asthenia " in Chinese medicine, the traditional Chinese medical science adopts symptomatic treatment, take tonifying speen and tonifying kidney, benefiting QI and nourishing blood as the rule for the treatment of.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment aplastic anemia is made by the Chinese medicine of following weight portion: Radix Codonopsis 7-12 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Rhodiolae 6-10 part, Fructus Schisandrae Chinensis 6-10 part, Cortex Eucommiae 9-13 part, Radix Achyranthis Bidentatae 10-15 part, Fructus Lycii 9-14 part, Semen Canavaliae 5-7 part, Semen Sesami Nigrum 7-12 part, Flos Sophorae 10-15 part, Rhizoma Polygonati 5-9 part, Semen Cassiae 5-7 part, Arillus Longan 9-13 part.

Preferably, the Chinese medicine preparation of this treatment aplastic anemia is made by the Chinese medicine of following weight portion: 10 parts of Radix Codonopsis, 13 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Radix Rhodiolaes, 8 parts of Fructus Schisandrae Chinensis, 11 parts of the Cortexs Eucommiae, 13 parts of Radix Achyranthis Bidentataes, 12 parts of Fructus Lycii, 6 parts of Semen Canavaliaes, 9 parts of Semen Sesami Nigrums, 13 parts, Flos Sophorae, 7 parts of Rhizoma Polygonatis, 6 parts of Semen Cassiaes, 11 parts of Arillus Longans.

Radix Codonopsis invigorating the spleen and replenishing QI in the side, the spleen invigorating lung benefiting; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, hidroschesis is antiabortive; The Radix Rhodiolae benefiting QI for activating blood circulation is promoted blood circulation and is relievingd asthma; The Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming; Cortex Eucommiae invigorating middle warmer benefit essence, invigorating the liver and kidney, bone and muscle strengthening; The Radix Achyranthis Bidentatae nourishing the liver and kidney, bone and muscle strengthening; The Fructus Lycii invigorating the liver and kidney, benefiting essence-blood; The Semen Canavaliae warming the middle warmer and descending qi, the kidney tonifying complement; The Semen Sesami Nigrum the liver and the kidney tonifying is moisturized spermatogenesis; The Flos Sophorae purging liver-fire, cooling blood for hemostasis; The Rhizoma Polygonati boosting qi and nourishing yin, tonifying speen and tonifying kidney; Semen Cassiae liver heat removing tomorrow, constipation relieving and the intestine moistening; The Arillus Longan invigorating the heart and spleen, nourishing blood to tranquillize the mind.

Above-mentioned Chinese medicine is made decoction by traditional decocting method.

Clinical data

1, physical data

Be 120 examples for the examination case, all from year January in May, 2007 to 2009 the court hematology be in hospital and the out-patient, be divided at random two groups.Treatment group 60 examples, wherein, male 35 examples, female's 25 examples; 17～60 years old age, average 28.5 years old.Matched group 60 examples, wherein, male 36 examples, female's 24 examples, 18～61 years old age, average 29 years old.Two groups of patients are at aspects such as sex, age, Clinical typings, through X ²Check, the difference not statistically significant has comparability.2, case is selected

All patients is Chronic Aplastic Anemia Patients by diagnosis of hematological diseases and criterion of therapeutical effect [1] diagnosis, and it is deficient that selected case tcm diagnosis all meets Liver and kidney, the asthenia of essence and blood card, and Western medicine diagnose belongs to chronic aplastic anemia.

3, Therapeutic Method

Treatment group is taken Chinese medicine preparation of the present invention, gets Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 13g, Radix Rhodiolae 8g, Fructus Schisandrae Chinensis 8g, Cortex Eucommiae 11g, Radix Achyranthis Bidentatae 13g, Fructus Lycii 12g, Semen Canavaliae 6g, Semen Sesami Nigrum 9g, Flos Sophorae 13g, Rhizoma Polygonati 7g, Semen Cassiae 6g, Arillus Longan 11g.Be decocted in water for oral dose, 1 dose of every day, day takes 2 times.

Matched group is selected to reproduce and is risen the blood sheet, (Liaoyuan City Yadong Chinese medicine company limited is produced, the accurate word Z22025856 of traditional Chinese medicines, lot number: 070301) oral, 1 time 5, every day 3 times, 3 months is 1 course for the treatment of.

4, criterion of therapeutical effect

Clinical recovery: anemia and bleeding disappear, and tcm clinical practice symptom, body weight disappear substantially, and the sign integration reduces ge; 95%.Hemoglobin: male 120g/L, women 100g/L; Leukocyte 4times; 109/L; Platelet 80times; 109/L.Produce effects: anemia and bleeding are clearly better, and tcm clinical practice symptom, body weight are obviously improved, and the sign integration reduces ge; 70%.Hemoglobin: male 120g/L, women 100g/L; Leukocyte 4times; 109/L; Platelet 80times; 109/L.Effectively: anemia and bleeding take a turn for the better, and tcm clinical practice symptom, sign take a turn for the better to some extent, and the sign integration reduces ge; 30%.Before treating, the hemogram such as hemoglobin increase to some extent.Invalid: anemia and bleeding are unchanged or increase the weight of, and tcm clinical practice symptom, sign are without obviously improving or increasing the weight of, and hemogram does not reach above-mentioned standard.

5, therapeutic outcome

Two groups of curative effects relatively see Table 1; Before and after two groups of treatments, the tcm clinical practice sings and symptoms changes relatively, sees Table 2.

Table 1 liang group aplastic anemia curative effect is (n) relatively

Two groups of aplastic anemia curative effect total effective rates compare, and difference has significance.

Before and after table 2 liang group treatment, symptom, sign disappearance improvement situation compare (n)

Two groups all are improved effect to tcm symptom, wherein Light-headedness, cardiopalmus tachypnea, soreness of the waist and knees, constipation with dry stool, two groups of comparisons of numb hand and foot symptom, and P equal 0.01 or 0.05, and difference has statistical significance, the treatment group matched group that is better than evident in efficacy.

Observed the indexs such as electrocardiogram, liver function, renal function during treatment, all changed without abnormal.

The specific embodiment

Example one: take Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 13g, Radix Rhodiolae 8g, Fructus Schisandrae Chinensis 8g, Cortex Eucommiae 11g, Radix Achyranthis Bidentatae 13g, Fructus Lycii 12g, Semen Canavaliae 6g, Semen Sesami Nigrum 9g, Flos Sophorae 13g, Rhizoma Polygonati 7g, Semen Cassiae 6g, Arillus Longan 11g.Be decocted in water for oral dose, 1 dose of every day, day takes 2 times.

Example two: take Radix Codonopsis 7g, Rhizoma Atractylodis Macrocephalae 15g, Radix Rhodiolae 6g, Fructus Schisandrae Chinensis 10g, Cortex Eucommiae 9g, Radix Achyranthis Bidentatae 15g, Fructus Lycii 9g, Semen Canavaliae 5g, Semen Sesami Nigrum 12g, Flos Sophorae 10g, Rhizoma Polygonati 5g, Semen Cassiae 7g, Arillus Longan 13g.Be decocted in water for oral dose, 1 dose of every day, day takes 2 times.

Example three: take Radix Codonopsis 12g, Rhizoma Atractylodis Macrocephalae 10g, Radix Rhodiolae 10g, Fructus Schisandrae Chinensis 6g, Cortex Eucommiae 13g, Radix Achyranthis Bidentatae 10g, Fructus Lycii 14g, Semen Canavaliae 7g, Semen Sesami Nigrum 7g, Flos Sophorae 15g, Rhizoma Polygonati 9g, Semen Cassiae 5g, Arillus Longan 9g.Be decocted in water for oral dose, 1 dose of every day, day takes 2 times.

Claims

1. Chinese medicine preparation for the treatment of aplastic anemia is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: Radix Codonopsis 7-12 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Rhodiolae 6-10 part, Fructus Schisandrae Chinensis 6-10 part, Cortex Eucommiae 9-13 part, Radix Achyranthis Bidentatae 10-15 part, Fructus Lycii 9-14 part, Semen Canavaliae 5-7 part, Semen Sesami Nigrum 7-12 part, Flos Sophorae 10-15 part, Rhizoma Polygonati 5-9 part, Semen Cassiae 5-7 part, Arillus Longan 9-13 part.

2. a kind of Chinese medicine preparation for the treatment of aplastic anemia according to claim 1 is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: 10 parts of Radix Codonopsis, 13 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Radix Rhodiolaes, 8 parts of Fructus Schisandrae Chinensis, 11 parts of the Cortexs Eucommiae, 13 parts of Radix Achyranthis Bidentataes, 12 parts of Fructus Lycii, 6 parts of Semen Canavaliaes, 9 parts of Semen Sesami Nigrums, 13 parts, Flos Sophorae, 7 parts of Rhizoma Polygonatis, 6 parts of Semen Cassiaes, 11 parts of Arillus Longans.