CN102784339A - Medicament for treating pulmonary tuberculosis by combined chemotherapy with traditional Chinese medicine Fuying and preparation method - Google Patents
Medicament for treating pulmonary tuberculosis by combined chemotherapy with traditional Chinese medicine Fuying and preparation method Download PDFInfo
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Abstract
The invention relates to a medicament for treating pulmonary tuberculosis by combined chemotherapy with traditional Chinese medicine Fuying and a preparation method; in the medicament, a traditional Chinese medicine of Fuying No. I comprises gecko, donkey-hide gelatin, stemona, adenophora stricta, radix ophiopogonis, prunella vulgaris, radix scrophulariae, fritillaria thun-bergli, cortex lycii radicis, bletilla striata, picrorhiza scrophulariiflora pennell, rehmanniae radix, and anemarrhena, and is mainly used for expelling evil and nourishing yang; a traditional Chinese medicine of Fuying No. II comprises codonopsis pilosula, Chinese yam, poria cocos, schisandra chinensis, radix rehmanniae preparata, angelica, caulis spatholobi, gentrin knotweed, bighead atractylodes rhizome, and radix astragali, and is mainly used for strengthening the body resistance and nourishing body; western medicines participating the combined chemotherapy comprise: streptomycin injections, isoniazid tablets, rifampin, and pyrazinamide capsules; during the combined chemotherapy with the medicines, not only stable therapeutic effect on pulmonary tuberculosis is realized, but also nourishing treatment effect on patients with hepatopathy is realized; during preparation, geckoes are grinded into fine powder, and fried with donkey-hide gelatin; then the other medicines are cleaned, dried, pulverized, and grinded into fine powder; the fine powder is sieved by a No. 6 sieve to obtain a pulvis; the pulvis is packaged into bags to obtain the Fuying No. I. During the preparation of the Fuying No. II, the medicines are also selected, cleaned, pulverized, and grinded into fine powder; the fine powder is sieved by a No. 6 sieve to obtain a pulvis; the pulvis is packaged into bags to obtain the Fuying No. II. During treatment, the traditional Chinese medicine Fuying is combined with western medicines for administration.
Description
[technical field]
The present invention relates to a kind of Chinese medicine and hold up win phthisical medicine of combination chemotherapy and method for preparing.
[background technology]
Tuberculosis, the traditional Chinese medical science are claimed " consumptive disease ", are commonly called as consumptive disease, and this disease is to have communicable chronic expendable illness, mainly are to become thin gradually etc. with cough, spitting of blood, hectic fever, night sweat and health to be its Clinical symptoms.How because of have a delicate constitution, insufficiency of vital energy and blood.Consumptive disease is invaded due to the lung by worm.Along with the reach of science, a large amount of novel antituberculotics has appearred, and can obtain medical treatment or cure through rationalizing the most patients of treatment, but still have considerable patient's focus can merge one or more cavities.New pathological changes will occur in the long-term chemotherapy, produce a toxic reaction to a drug.Many hospitals are in phthisical chemotherapy, and what mostly adopt is the Western medicine chemotherapy, but Western medicine will develop immunity to drugs in long-term chemotherapy, hindered further medication, brought huge economic pressures and stress for patient and family.
[summary of the invention]
The object of the invention will provide a kind of Chinese medicine to hold up win phthisical medicine of combination chemotherapy and method for preparing exactly; This medicine holds up the win Western medicine to carry out combined chemotherapy to pulmonary tuberculosis with Chinese medicine; What is called is held up win, and it contains view is to get " internal diameter " " osteanabrosis, imperial palace is sagged; fullness caused by stagnant QI in the heart, the inconvenience of panting, interior pain are drawn shoulder item, fever of the body, taken off Nei Po popliteal ".
Win is: become thin, weak meaning, hold up to win and help, nourish.
Hold up the win implication to be: to nourish and subsidize the body constitution of becoming thin, make it strong, healthy meaning.The present invention is the coupling group with the case of Chinese and western medicine drug combination, and the medication case with the Western medicine chemotherapy is a chemotherapy group merely, the existing chemotherapy data of from the medical record patient, taking out.(1) 6 months persons of all course of therapy, the normal person of liver function before the treatment.(2) X line rabat has reversible pathological changes, and the focus addition is more than or equal to a side lung 1/3 lung page or leaf, or does not have empty person.(3) two groups of case basic conditions are roughly the same, existing from medical record, propose 240 routine lungers, and disease is divided into two groups at random, win the chemotherapeutics group and claim the coupling group for containing to hold up for one group, and another group is used the chemicals group for list.
Wherein coupling group 120 examples, male 68 examples, women 52 examples, the range of age 20～60 years old, 40 years old mean age; Just control 55 examples, control 65 examples again; III type 106 examples, II type 14 examples, the expectorant bacterium is coated with positive 57 examples.
Chemotherapy group 120 examples, male 72 examples, women 48 examples; The range of age 20～60 years old, 39 years old mean age; Just control 58 examples, control 62 examples again; III type 102 examples, II type 18 examples, the expectorant bacterium is coated with positive 58 examples.
In the therapeutic process; The coupling group is promptly used Chinese medicine medicine of the present invention to carry out strengthening vital QI to eliminate pathogenic factors to be principle of treatment; Chinese medicine medicine of the present invention also claims to hold up the win treatment; The present invention will hold up among the win medicine to be divided into to hold up and win I number and win II number with holding up, wherein hold up win mainly be for I number with eliminating evil be main, newly call and eliminating evilly be exactly: " anti-consumptive disease parasite killing, YIN nourishing training sky ";
Holding up win is main to set upright II number, and what is called is set upright and is exactly: nourish tonify deficiency.
Hold up the combination ingredient of win to be described further with regard to Chinese medicine below:
1, hold up win I number, form by following flavor medicine and weight ratio:
Gecko 8～17 gram Colla Corii Asini 15～20 gram Radixs Stemonae 15～25 grams
Radix Adenophorae (Radix Glehniae) 15～25 gram 15～25 gram Spica Prunellaes Radix Ophiopogonis 10～15 grams
Radix Scrophulariae 15～20 gram Bulbus Fritillariae Uninbracteataes 10～15 gram Cortex Lycii 15～20 grams
The Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 grams
Be in the machine of its compatibility
The Gecko levigation, since salty flat, be lung stomach warp, can be helped kidney yang by lung qi, decide the sound of sth. throbbing or bursting and cough, benefiting essence-blood.
Colla Corii Asini: sweetly put down, return lung, liver, kidney channel, tonifying blood and arresting bleeding, nourishing YIN and moistening the lung.
The Radix Stemonae: sweet in the mouth, hardship, put down, return lung, warp, nourishing the lung to arrest cough, parasite killing.
Radix Adenophorae (Radix Glehniae): sweet in the mouth, be slightly cold, attach to the lung and stomach meridians, clearing lung and nourishing yin, reinforcing stomach reg fluid.
Radix Ophiopogonis: sweet in the mouth, little hardship, tremble with fear, return lung, the heart, stomach warp, lung moistening, yin nourishing, reinforcing stomach reg fluid, relieving restlessness clears away heart-fire.
Spica Prunellae: bitter in the mouth, suffering, tremble with fear, return liver, gallbladder meridian, clearing away liver-fire, strongly fragrant whole, the blood pressure lowering of loosing.
Radix Scrophulariae: sweet-bitter flavor, salty-cold, return lung, stomach kidney, heat clearing away, detoxifcation, yin nourishing.
Bulbus Fritillariae Cirrhosae: bitter in the mouth, hardship, be slightly cold, return lung heart channel, preventing phlegm from forming and stopping coughing, heat clearing away eliminating stagnation.
Cortex Lycii: sweet in the mouth, light, tremble with fear, return lung, kidney channel, removing heat from blood to move back steaming, clearing away lung-heat.
The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter but sweet flavor, puckery, be slightly cold, return lung, liver, stomach warp, astringing to arrest bleeding, lung heat clearing granulation promoting.
The above-mentioned medicine of respectively distinguishing the flavor of is pressed monarch drug, ministerial drug, adjuvant drug] do further to analyze.
Monarch drug is that the Gecko powder fries Colla Corii Asini among the we, and wherein Gecko plays the effect of " treating YIN within YANG ", and Colla Corii Asini plays and enriches blood, hemostasis, nourishing YIN and moistening the lung, the two plays the effect of tonifying the lung benefit essence after closing altogether effectively to kill day tulase.Ministerial drug sand, ginseng, Radix Ophiopogonis, Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Stemonae can help to foster cloudy lung moistening, parasite killing, tonifying the lung astringing to arrest bleeding, pulmonary tuberculosis is had certain effect in addition; Its adjuvant drug be the river owe mother, the Radix Rehmanniae, soothing the liver, regulate the flow of vital energy, tubercule bacillus had certain inhibitory action; But its messenger drug is Cortex Lycii, Rhizoma Picrorhizae clearind deficient heat, to pulmonary tuberculosis heating] night sweat has certain curative effect.
From above analysis; Holding up win I Therapeutic Principle is principle of treatment with " eliminating evil YIN nourishing ", is the roman thought of prescription, can reach very fast healing effect to pulmonary tuberculosis cavity; Effectively kill a day tulase, tubercule bacillus is had certain inhibitory action, pulmonary tuberculosis heating, night sweat are had very fast therapeutical effect; Roman prescription is rigorous, gives full play to the effect that monarch in the prescription, minister, assistant make, and does not have untoward reaction such as restriction or checking relation in five elements, the mutual-detoxication.
Below further analyze to hold up and win II number, its composition and dosage thereof are:
Radix Codonopsis 15～25 grams, Rhizoma Dioscoreae 15～30 grams, Poria 15～20 grams, Fructus Schisandrae Chinensis 10～12 grams.
Radix Rehmanniae Preparata 10～25 grams, Radix Angelicae Sinensis 8～15 grams, Caulis Spatholobi 10～15 grams, Rhizoma Polygoni Cuspidati 10～15 grams.
The Rhizoma Atractylodis Macrocephalae 10～15 grams, the Radix Astragali 15～25 grams.
Be in the machine of its compatibility:
Radix Codonopsis: sweet in the mouth, put down, return spleen channel, by in QI invigorating, promote the production of body fluid and nourish blood.
Rhizoma Dioscoreae: sweet in the mouth, put down, return spleen lung kidney channel, supplementing QI and nourishing YIN, spleen reinforcing, lung kidney.
Poria: sweet in the mouth, light flat, GUIXIN spleen, kidney channel, promoting diuresis to eliminate damp pathogen, spleen invigorating.
Fructus Schisandrae Chinensis: distinguish the flavor of diligent, wet, be lung, kidney, heart channel, hold back the liver nourishing kidney, the arresting sweating that promotes the production of body fluid, mind tranquilizing and the heart calming.
Radix Rehmanniae Preparata: sweet in the mouth, littlely wet, return liver, kidney channel, nourishing the blood and yin, vital essence replenishing and marrow benifiting.
Radix Angelicae Sinensis: sweet in the mouth, suffering, temperature, return liver heart spleen, enrich blood, invigorate blood circulation, pain relieving, lung moistening.
Caulis Spatholobi: bitter in the mouth, little sweet, warm, return that Liver Channel, blood are enriched blood, relaxing muscles and tendons and activating QI and blood in the collateral.
Rhizoma Polygoni Cuspidati: bitter in the mouth, tremble with fear, return liver, gallbladder, lung meridian, invigorate blood circulation, heat clearing away, preventing phlegm from forming and stopping coughing.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, sweet, warm, return spleen lung meridian, QI invigorating, QI invigorating, granulation promoting, diuretic.
The Radix Astragali: the sweet in the mouth tepor, return spleen, lung meridian, QI invigorating, QI invigorating, granulation promoting, diuretic.
The above-mentioned medicine of respectively distinguishing the flavor of, do a step by monarch drug, ministerial drug, adjuvant drug, messenger drug and analyze.
Monarch drug: with Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae is merit, the levelling human body immune function of group, powerful QI invigorating.
Ministerial drug: with Radix Rehmanniae Preparata, Caulis Spatholobi, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae serve as that group can nourish blood, enriches blood, invigorates blood circulation, blood vessel dilating, microcirculation improvement, strengthen hole tuberculosis drug effect fruit.
Adjuvant drug is a group with Poria, Rhizoma Polygoni Cuspidati, but spleen invigorating, heat clearing away, reduces phlegm, calms the nerves.Messenger drug is a Fructus Schisandrae Chinensis, can promote the production of body fluid arresting sweating, cough-relieving.
Hold up win II number, Therapeutic Principle to be principle of treatment from above analysis for " setting upright nourishing ".Be to consist of roman thought, align body in addition in addition, immune function, human body immunity improving power is given full play to the effect of medicine, effectively kills tulase, thereby improves curative effect.Because prescription is careful, give full play to monarch, minister, help, make the effect of each medicine, do not have the untoward reaction of the mutual-detoxication, restriction or checking relation in five elements.
Another object of the present invention is an its preparation method.
Be described in detail below and hold up win I number and hold up the method for preparing of winning II number.
Hold up and win I number:
Earlier Gecko pulverization and Colla Corii Asini are fried in shallow oil stir-fry during preparation, again each medicine of distinguishing the flavor of is cleaned, dries, pulverizes, pulverization sieves into powder after No. 6, is packaged into bag.
Hold up and win II number:
Produce and hold up when winning II, equally with each medicine select, clean, dry, pulverizing, pulverization, cross No. 6 and sieve into powder, packing, one-tenth bag.
For making the present invention obtain curative effect and the function of giving full play to combined chemotherapy better, the title and the consumption of Western medicine are narrated at present:
The streptomycin injection, consumption is with 0.73 gram of intramuscular injection once a day～0.9 gram;
Isoniazid tablets: consumption is every day three times, each 0.2～0.5 gram;
Rifampicin: consumption is every day three times, each 0.3～0.5 gram;
The pyrazinamide capsule: consumption is secondary every day, obeys 1～3 gram after the meal.
Be described in detail the pharmacy mechanism of the Western medicine of respectively distinguishing the flavor of at present:
Key mycin injection:
For broad-spectrum halogen glucoside antibiotics, tubercule bacillus there is powerful bacteriostastis, it is strong under alkaline environment, to kill the tulase effect, is " half bactericide ".
The mechanism of action: disturb tubercule bacillus proteinic synthetic and reach system bacterium effect.
Rifampicin: low agricultural degree is antibacterial, and the high concentration antibacterial has the film of striding ability, and the target enzyme is had stronger affinity, can get into and play bactericidal action in the cell, because the inside and outside vigorous tuberculosis flora of metabolism of its cell all has bactericidal action, so " full bactericide ".
Isoniazid tablets:
1, suppresses the required burning reductase of antibacterial, thereby suppress bacterial metabolism.
2, acid and alkali, alkali environmental effect, the inside and outside tulase of pair cell all has bactericidal action, particularly eugonic breeding bacterium effect strong " full bactericide ".
Pyrazinamide:
Only limit in the cell, and be " half bactericide " under the sour environment.
The present invention is because blending the east and the west, and the combined chemotherapy pulmonary tuberculosis obtains better curative effect.
In to numerous lungers, also have some not only to suffer from pulmonary tuberculosis; The patient who also suffers from hepatopathy; If single can only have better curative effect to pulmonary tuberculosis with chemotherapy group (being Western medicine) chemotherapy; But inoperative to hepatopathy, and the present invention has taked Chinese medicine to hold up win to carry out the phthisical while of combination chemotherapy to the patient who suffers from hepatopathy, also the patient has been played dual curative effect.
[specific embodiment]
Following the present invention makes up with best compatibility, as following examples:
Hold up and win I number, form by following flavor medicine and weight ratio:
The Gecko levigation 10 gram Colla Corii Asini 18 gram Radixs Stemonae 20 gram Radix Adenophorae (Radix Glehniae) 18 grams
Radix Ophiopogonis, 20 gram Spica Prunellaes, 12 gram Radix Scrophulariaes, 18 gram Bulbus Fritillariae Uninbracteataes 12 restrained
The Cortex Lycii 18 gram Pseudobulbus Bletillae (Rhizoma Bletillae)s 12 KEHU Rhizoma Coptidis 12 gram Radix Rehmanniae 30 grams
The Rhizoma Anemarrhenae 18 grams
Hold up and win II number
Radix Codonopsis 20 Keshan medicines 25 gram Poria 18 gram Fructus Schisandrae Chinensis 10 grams
Radix Rehmanniae Preparata 20 gram Radix Angelicae Sinensis 10 gram Caulis Spatholobis 12 gram Rhizoma Polygoni Cuspidati 12 grams
The Rhizoma Atractylodis Macrocephalae 12 gram Radixs Astragali 20 grams
During preparation:
Earlier Gecko pulverization and Colla Corii Asini are fried in shallow oil stir-fry, again each flavor medicine is cleaned, dries, pulverizes, pulverization sieves into powder after No. 6; Be packaged into bag, hold up and win I number, take half an hour after meal, produce and hold up when winning II; Equally with each medicine select, clean, pulverizing, pulverization, cross No. 6 and sieve into powder, packing, one-tenth bag, hold up and win II number; Take half an hour ante cibum, during treatment, unites compatibility, takes with Western medicine.
The Western medicine combination of combined chemotherapy has:
The streptomycin injection: consumption is for once a day, and intramuscular injection 0.78 restrains;
Isoniazid tablets: consumption is every day three times, obeys 0.4 gram at every turn;
Rifampicin: consumption is every day three times, obeys 0.4 gram at every turn;
The pyrazinamide capsule: consumption is secondary every day, obeys 2 grams after the meal.
The front has been mentioned the coupling group and has been the Chinese and western medicine drug combination, and chemotherapy group also is simple chemotherapy medication.
Below two groups of comparisons of carrying out the comprehensive function situation of change, the treatment of two groups of cases is after 6 months, following about the comprehensive function situation of change, normal 115 examples of coupling group, unusual routine 5 examples, normal 91 examples of chemotherapy group, unusual 29 examples, concrete data are seen table 1:
Table 1 liang group is about the comparison (example) of changes of liver function situation
| Group | The example number | Normally | Lead normal | Natural rate of interest (%) |
| The coupling group | 120 | 115 | 5 | 95.8 |
| Chemotherapy group | 120 | 91 | 29 | 75.8 |
| Add up to | 240 | 206 | 34 | 85.8 |
The result shows that coupling group natural rate of interest is 95.8%, and chemotherapy group is 75.8%.
Two groups are compared through statistical procedures, and difference has statistical significance (P＞0.05).Show two groups bigger about changes of liver function situation difference, explain that the liver protective effect of coupling group is superior to chemotherapy group, prompting Chinese medicine holds up win series aspect liver function protecting, unique effect to be arranged.
After two groups of two groups of cases of comparison about cure rate were treated 6 months, following about the cure rate situation, the coupling group was cured 116 examples, and 3 examples that take a turn for the better do not have 1 example of change; Chemotherapy group is cured 105 examples, and 13 examples that take a turn for the better do not have 2 examples of change.Concrete data are seen table 2.
The result shows that coupling group cure rate is 96.7, and chemotherapy group is 87.5%.Two groups are compared through statistical procedures, and difference has statistical significance (P＞0.05).Show two groups bigger about the cure rate difference, explain that the coupling group treats phthisical whole structure and be superior to chemotherapy group, Chinese medicine is held up and is won the coupled in series chemotherapy and aspect the phthisical whole cure rate of treatment potentiation is being arranged.
The comparison (example) of table 2 liang group therapeutic effect
| Group | The example number | Cure | Take a turn for the better | No change | Cure rate (%) |
| The coupling group | 120 | 116 | 3 | 1 | 96.7 |
| Chemotherapy group | 120 | 105 | 13 | 2 | 87.5 |
| Add up to | 240 | 221 | 16 | 3 | 92.1 |
Annotate: P:=0.025
The comparison of two groups of untoward reaction, two groups in therapeutic process untoward reaction a situation arises as follows, have 5 examples untoward reaction to occur in the chemotherapy group, that symptom has is nauseating, vomiting, stomach discomfort etc., does not interrupt drug withdrawal through anti symptom treatment.And the coupling group only has 2 examples to occur.
Clinical control through two group of 240 routine pulmonary tuberculosis case is observed, and the negative conversion rate of the expectorant tulase smear of coupling group is 84.2%, and chemotherapy group is 82.8%, two group and compares through statistical procedures difference not statistically significant (P＞0.05).Two groups of comparisons about X line focus absorbing state, the result shows that coupling group absorbance is 98.3%, chemotherapy group is 97.9%.Two groups are compared through statistical procedures difference not statistically significant (P＞0.05).Show two groups little about X line focus absorbing state difference.Two groups of comparative results about the changes of liver function situation show that coupling group natural rate of interest is 95.8%, and chemotherapy group is 75.8%.Two groups are compared through statistical procedures, and difference has statistical significance (P＜0.05).Show two groups bigger about changes of liver function situation difference, explain that the liver protective effect of coupling group is superior to chemotherapy group, prompting Chinese medicine holds up win series aspect liver function protecting, unique effect to be arranged.Two groups of comparisons about cure rate, the result shows that coupling group cure rate is 96.7%, chemotherapy group is 87.5%.Two groups are compared through statistical procedures, and difference has statistical significance (P＜0.05).Show two groups bigger about the cure rate difference, explain that the coupling group treats phthisical whole structure and be superior to chemotherapy group, prompting Chinese medicine is held up and is won the coupled in series chemotherapy and aspect the phthisical whole cure rate of treatment potentiation is being arranged.Two groups of comparisons about side reaction, two groups in therapeutic process side reaction a situation arises as follows, have 5 examples side reaction to occur in the chemotherapy group, symptom has: feel sick, vomiting, stomach discomfort etc. do not interrupt drug withdrawal through anti symptom treatment.And the coupling group only has 2 examples to occur.
Model case
1, patient, man, 46 years old, Shuangliao, Jilin people from county, my institute's diagnosis and treatment over 2004.The patient before 2 days no any inducement cough, hectic fever, night sweat, weak, poor appetite appear, treat with intrapulmonary infection in local hospital, the state of an illness increases the weight of and comes my institute's diagnosis and treatment.Through X line rabat and plate coating checking prompting lung infiltrative pulmonary tuberculosis, tcm diagnosis: pulmonary tuberculosis (YIN-deficiency type of the lung and kidney).History of past illness: hectic clinical cure once before 8 years.Hold up at present and won serial Chinese medicine cooperation Western medicine chemotherapy 6 months, symptom is obviously improved, and expectorant is cloudy after 2 months changes, and finishes X line rabat check disease kitchen range through the course of treatment and obviously absorbs, and follows up a case by regular visits to 1 year, does not see recurrence so far.
2, Jin Fu, man, 42 years old, people from Lishu County.My institute's diagnosis and treatment over 1999, one week of patient, no obvious inducement went out low grade fever, cough, expectorant less; With " intrapulmonary infection " treatment, the state of an illness increases the weight of after the week, and comes my institute's diagnosis and treatment in local hospital; Through the X rabat and be coated with biopsy and look into the left lung of prompting and soak into pulmonary tuberculosis, tcm diagnosis pulmonary tuberculosis (deficiency of lung-YIN type), history of past illness: hectic clinical cure once before 8 years; Hold up the serial Chinese medicine two of win to control the Western medicine chemotherapy after six months, symptom is obviously improved at present, and the expectorant limit is changeed after 2 months; Finish X line rabat reexamine focus through the course of treatment and obviously absorb, followed up a case by regular visits to 1 year, do not see recurrence so far.
3, Li Jinlan, woman, 62 years old, people from Changtu County.My institute's diagnosis and treatment of calendar year 2001, the patient before two months no obvious inducement be interrupted cough, a little whitish yellow sputum, weak, idol is breathed hard, the activity postemphasis does not have heating, no night sweat.With " upper respiratory infection " treatment, the state of an illness increases the weight of after three days in local hospital, after the doubtful pulmonary tuberculosis of rabat is clapped by local hospital; So, check pulmonary tuberculosis on the two lungs of prompting, expectorant smear mutually through necessity for system comes my institute; Tcm diagnosis pulmonary carcinoma (type of deficiency of both QI and YIN); Previously do not have the pulmonary tuberculosis history, hold up at present and won serial Chinese medicine cooperation Western medicine chemotherapy six months, symptom is obviously improved (back is the same).
4, Zou Jinxia, woman, 51 years old, Shuangliao people from county.My institute's diagnosis and treatment over 2002, the patient is no obvious inducement fever before three months, and 37.5 ℃, yellow expectorant is breathed hard; The activity postemphasis, no night sweat, dry mouth and throat, in local chest film inspection pulmonary tuberculosis, hectic once before 20 years previously; Event speed is come my institute's diagnosis and treatment, through pressing inspection mutually, diagnosis, middle infiltrative pulmonary tuberculosis on two lungs; Overdraw district on the right lung, smear, tcm diagnosis: pulmonary carcinoma (type of deficiency of both QI and YIN), surplus the same.
5 Yang Zi rivers, man, 35 years old, Gongzhuling City people; Before patient's two weeks, do not have obvious inducement and occur, fever, cough, white expectorant, beans antiperspirant, dry mouth and throat; The medication voluntarily (concrete medication not quite clear) of being in is not seen and is come my institute, in film making, smear are diagnosed on the left pulmonary tuberculosis lung; Abundant expectoration, tcm diagnosis pulmonary tuberculosis (type of hyperactivity of fire caused by deficiency of YIN), surplus the same.
6, Liang Zhongwu, man, 68 years old, Guo Jia people from shop; The patient did not have obvious inducement before fortnight, and cough, thin, cold sweating night sweat, low bath, insomnia, diet, sleep is all not good enough; Through local examination in hospital, doubtful " pulmonary tuberculosis " for asking system diagnostics and treatment, and come my institute; Tuberculosis, expectorant bacterium under on warp film making CT examination, smear, the two lungs of diagnosis, tcm diagnosis: pulmonary tuberculosis (lung yin sun deficiency), surplus the same.
7, Wu Gang, the man, 36 years old, people from Siping City, before patient's one star, dry cough, few expectorant, weak, activity postemphasis, pulmonary tuberculosis on the doubtful right lung, the expectorant bacterium, tcm diagnosis: pulmonary tuberculosis (deficiency of lung-YIN type) previously: health.
8, high refined half the, the woman, 49 years old, elm people from county, patient did not have obvious inducement before half a year, had a fever 37.3-38 ℃ night sweat, feverish sensation in the palms and soles, thin, dry mouth and throat.
Diagnosis: tuberculosis (on be cavity) tcm diagnosis on two lungs, YIN-deficiency type of the lung and kidney.
9, Wu Chunfang, the woman, 38 years old, two mausoleums Ziren, the patient is before one week, occur cough, weak, breathe hard, the activity postemphasis, it is not good enough to sleep.Diagnosis: pulmonary tuberculosis on the left lung, expectorant is coated with, tcm diagnosis: pulmonary carcinoma (type of deficiency of both QI and YIN).
10, Liu Shulai, the woman, 72 years old, people from Changtu County occurred before patient's two weeks cough, breathes heavily, yellow sputum, nothing fever, even night sweat, breathed hard, the activity postemphasis the past pulmonary tuberculosis medical history 30 years.
Diagnosis: tuberculosis is coated with tcm diagnosis under on two lungs: pulmonary tuberculosis (type of deficiency of both QI and YIN).
11, Wang is faithful and upright, the man, and 49 years old, lonely home people from town, patient low grade fever, night sweat occurred, become thin before 10 days, feverish sensation in the palms and soles, dry mouth and throat, previously healthy.
Diagnosis: tuberculosis on two lungs, abundant expectoration, tcm diagnosis: pulmonary carcinoma (type of hyperactivity of fire caused by deficiency of YIN).
Tuberculosis is the chronic infectious disease of serious harm human health.China's tuberculosis epidemic situation is more serious, is one of the high burden of 22 tuberculosis in whole world country, and the lunger is only second to India, occupies second.The sternness property of tuberculosis epidemic situation directly influences people health and national economy situation.The epidemic situation of grasp and controlling tuberculosis is the major issue that is related to national economy, is the important evidence of working out targeted prevention and control measure.
Claims (4)
1. a Chinese medicine is held up and is won the phthisical medicine of combination chemotherapy, it is characterized in that:
The invention medicine is synthetic by following Chinese medicine and western medicine; Drug matching; According to each medicine effect; Act on, be divided into according to monarch, minister, the relation that makes, helps and hold up win I number and hold up win II number; It holds up the Chinese medicine of winning the I compatibility that Gecko, Colla Corii Asini, the Radix Stemonae, Radix Adenophorae (Radix Glehniae), Radix Ophiopogonis, Spica Prunellae, Radix Scrophulariae, Bulbus Fritillariae Uninbracteatae, Cortex Lycii, the Pseudobulbus Bletillae (Rhizoma Bletillae), Picrorhiza scrophulariiflora, the Radix Rehmanniae, the Rhizoma Anemarrhenae are arranged, and holds up that the Chinese medicine of winning the II compatibility has that Radix Codonopsis, Rhizoma Dioscoreae, Poria, Fructus Schisandrae Chinensis, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Sanguis Gallus domesticus are risen, Rhizoma Polygoni Cuspidati, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, and the Western medicine of participating in combined chemotherapy has streptomycin injection, isoniazid tablets, rifampicin, pyrazinamide capsule.
2. a kind of Chinese medicine according to claim 1 is held up and is won the phthisical medicine of combination chemotherapy, it is characterized in that:
(1) holds up win I number
The weight ratio of medicine of respectively distinguishing the flavor of in its compatibility is:
Gecko 8～17 restrains, Colla Corii Asini 15～20 restrains, the Radix Stemonae 15～25 restrains, Radix Adenophorae (Radix Glehniae) 15～25 restrains, restrain Radix Ophiopogonis 15～25, Spica Prunellae 10～15 restrains, Radix Scrophulariae 15～20 restrains, Bulbus Fritillariae Uninbracteatae 10～15 restrains, Cortex Lycii 15～20 restrains, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 restrains, Rhizoma Picrorhizae 10～15 restrains, the Radix Rehmanniae 20～40 restrains, the Rhizoma Anemarrhenae 15～20 restrains;
(2) hold up win II number
The weight ratio of medicine of respectively distinguishing the flavor of in its compatibility is:
Radix Codonopsis 15～25 grams, Rhizoma Dioscoreae 15～30 grams, Poria 15～20 grams, Fructus Schisandrae Chinensis 10～12 grams, Radix Rehmanniae Preparata 10～25 grams, Radix Angelicae Sinensis 8～15 grams, Caulis Spatholobi 10～15 grams, Rhizoma Polygoni Cuspidati 10～15 grams, the Rhizoma Atractylodis Macrocephalae 10～15 grams, the Radix Astragali 15～25 grams;
(3) the Western medicine compatibility weight ratio of participation combined chemotherapy is:
The streptomycin injection: consumption is for once a day, and intramuscular injection 0.73 gram～0.9 restrains;
Isoniazid tablets: consumption is every day three times, each 0.2～0.5 gram, noon or late taking medicine after meal;
Rifampicin: consumption is every day three times, each 0.3～0.5 gram, early taking medicine after meal;
The pyrazinamide capsule: consumption is secondary every day, each 1～3 gram, late taking medicine after meal;
3. hold up with 2 one kinds of Chinese medicines according to claim 1 and win the phthisical medicine of combination chemotherapy, it is characterized in that the best dosage of the present invention is:
(1) holds up win I number
Gecko 10 restrains, Colla Corii Asini 18 restrains, the Radix Stemonae 20 restrains, Radix Adenophorae (Radix Glehniae) 18 restrains, restrain Radix Ophiopogonis 20, Spica Prunellae 12 restrains, Radix Scrophulariae 18 restrains, Bulbus Fritillariae Uninbracteatae 12 restrains, Cortex Lycii 18 restrains, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 restrains, Rhizoma Picrorhizae 12 restrains, the Radix Rehmanniae 30 restrains, the Rhizoma Anemarrhenae 18 restrains;
(2) hold up win II number
Radix Codonopsis 20 grams, Rhizoma Dioscoreae 25 grams, Poria 18 grams, Fructus Schisandrae Chinensis 10 grams, Radix Rehmanniae Preparata 20 grams, Radix Angelicae Sinensis 10 grams, Caulis Spatholobi 12 grams, Rhizoma Polygoni Cuspidati 12 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, the Radix Astragali 20 grams;
(3) Western medicine in the combined chemotherapy with every day optimum amount be:
The streptomycin injection: consumption is for once a day, and intramuscular injection 0.78 restrains;
Isoniazid tablets: consumption is every day three times, obeys 0.4 gram at every turn;
Rifampicin: consumption is every day three times, obeys 0.4 gram at every turn;
The pyrazinamide capsule: consumption is secondary every day, obeys 2 grams after the meal.
4. hold up according to right 1-3 Chinese medicine and win phthisical medicine of combination chemotherapy and method for preparing, earlier Gecko pulverization and Colla Corii Asini are fried in shallow oil stir-fry when it is characterized in that preparing, again each flavor medicine is cleaned, dries, pulverizes; Pulverization sieves into powder after No. 6, is packaged into bag; Hold up and win I number, take half an hour after meal, produce and hold up when winning II; Equally with each medicine select, clean, pulverizing, pulverization, cross No. 6 and sieve into powder, packing, one-tenth bag, hold up and win II number; Take half an hour ante cibum, during treatment, unites compatibility, takes with Western medicine.
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| CN103656406A (en) * | 2013-11-21 | 2014-03-26 | 蒋学 | Medicine for treating phthisis and preparation method of medicine |
| CN103656422A (en) * | 2013-11-20 | 2014-03-26 | 田博 | Traditional Chinese medicine composition for treating asthmatic bronchitis |
| CN105055860A (en) * | 2015-08-24 | 2015-11-18 | 臧兰恕 | Traditional Chinese medicine composition for treating yin deficiency fire excess type phthisis |
| CN111407865A (en) * | 2020-04-13 | 2020-07-14 | 贺启飞 | Pulmonary perforation combined traditional Chinese medicine formula for treating pulmonary tuberculosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103656422A (en) * | 2013-11-20 | 2014-03-26 | 田博 | Traditional Chinese medicine composition for treating asthmatic bronchitis |
| CN103656422B (en) * | 2013-11-20 | 2016-04-20 | 田博 | A kind of Chinese medicine composition for the treatment of asthmatic bronchitis |
| CN103656406A (en) * | 2013-11-21 | 2014-03-26 | 蒋学 | Medicine for treating phthisis and preparation method of medicine |
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| CN105055860A (en) * | 2015-08-24 | 2015-11-18 | 臧兰恕 | Traditional Chinese medicine composition for treating yin deficiency fire excess type phthisis |
| CN111407865A (en) * | 2020-04-13 | 2020-07-14 | 贺启飞 | Pulmonary perforation combined traditional Chinese medicine formula for treating pulmonary tuberculosis |
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| CN102784339B (en) | 2014-07-23 |
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