CN102727749B - Medicine for treating aplastic anemia - Google Patents
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Abstract
The invention discloses a medicine for treating aplastic anemia, which is used for solving the treatment problem of aplastic anemia. The medicine is characterized by being prepared from processing various traditional Chinese medicines, and comprises the active pharmaceutical ingredients in parts by weight: 6-10 parts of astragalus, 8-15 parts of polygonatum, 8-15 parts of glossy privet fruit, 6-10 parts of flueggea suffruticosa, 6-10 parts of ox horn bone, 8-15 parts of largehead atractylodes rhizome, 6-10 parts of angelica, 8-15 parts of herba cladostachvdis and 3-6 parts of humifuse euphorbia herb. Clinical experiments show that the medicine for treating aplastic anemia has the characteristics of good curative effect and higher safety, and is worth being clinically applied and popularized.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to treat the medicine of aplastic anemia.
Background technology
Aplastic anemia (aplastic anemia, AA) is to reduce or a kind of anemia due to the obstacle occurs because of hemopoietic function of bone marrow, is called for short " aplastic anemia ".Main manifestations is hemopoietic hypofunction of marrow, pancytopenia and anemia, hemorrhage, infection syndrome.The anxious weight that relaxes the state of an illness according to onset can be divided into acute and chronic two kinds.The characteristics of acute are, from the beginning of anemia and not obvious, often take hemorrhage, infection, high heat as onset symptoms, but disease progression is fast, and serious anemia namely occurs rapidly soon: hemorrhage serious and extensively, and not only skin, mucosa and retinal hemorrhage, and often with visceral hemorrhage; Infection is more common in around oral cavity, pharynx, skin and the anus, and the height that is caused by pneumonia, septicemia etc. is warm; The course of disease is through dangerous, and the patient is everlasting in a short time because of infection or visceral hemorrhage death.The chronic type onset is slow, and except the chronic progressive external anemia was arranged, often with skin and mucosal bleeding, severe patient was often with infecting and heating.The rare spontaneous recovery person of aplastic anemia in case make a definite diagnosis, answers active treatment.The treatment of aplastic anemia mainly is supporting treatment, short hemopoietic and bone marrow transplantation, and so-called supporting treatment mainly is that infusion erythrocyte and platelet are to keep cytometry.And Transfusion easily causes blood transfusion property hemachromatosis, and only uses the hemopoietic growth factors such as G-CSF, EPO to the short hemopoietic treatment of aplastic anemia patient row, and is clinical in remarkable result.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and the medicine of the sure treatment aplastic anemia of a kind of curative effect is provided.
The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of aplastic anemia, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of the Radixs Astragali, 8 ~ 15 parts of Rhizoma Polygonatis, 6 ~ 10 parts of 8 ~ 15 parts of Cacumen Securinegae Suffruticosaes of Fructus Ligustri Lucidi, 6 ~ 10 parts on the Cornu Bovis seu Bubali cheek, 8 ~ 15 parts of the Rhizoma Atractylodis Macrocephalaes, 6 ~ 10 parts of Radix Angelicae Sinensis, 8 ~ 15 parts of nine layers of wind, 3 ~ 6 parts of Herba Euphorbiae Humifusaes.
Its optimum weight proportioning is: 8 parts of the Radixs Astragali, 10 parts of Rhizoma Polygonatis, 10 parts of Fructus Ligustri Lucidi, 8 parts of Cacumen Securinegae Suffruticosaes, 8 parts on the Cornu Bovis seu Bubali cheek, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Radix Angelicae Sinensis, 10 parts of nine layers of wind, 5 parts of Herba Euphorbiae Humifusaes.
Wherein said: the Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor are sweet, temperature.Return lung, spleen channel.But the merit invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
Rhizoma Polygonati is the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor are sweet, and are flat.Return spleen, lung, kidney channel.But the merit boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait..Nature and flavor are sweet, bitter, cold.Return liver, kidney channel.But the merit nourishing the liver and kidney, black hair makes eye bright.
Cacumen Securinegae Suffruticosae is browse or the root of euphorbia plant Suffrutescent Securinega Twig Securinega suffruticosa (Pal1.) Rehd..Acrid in the mouth; Bitter; Slightly warm in nature.Return liver; Kidney; Spleen channel.But merit expelling wind and activating blood circulation; The strong muscle of kidney tonifying.
The Cornu Bovis seu Bubali cheek is Artiodactyla Bovidae cattle Bos taurus domesticus Gmelin, is used as medicine with the inner hard bone heart of Cornu Bovis seu Bubali.Nature and flavor are bitter, temperature.Merit can be stopped blooding.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor are bitter, sweet, temperature.Return spleen, stomach warp.But the merit invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.
Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, hot, temperature.Return liver, the heart, spleen channel.Merit can be enriched blood and be invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, and invigorates blood circulation collateral dredging.
Herba Euphorbiae Humifusae is the dry herb of euphorbia plant Radix seu Caulis Parthenocissi tricuspidatae Euphorbia humifusa Willd. or Herba Euphorbiae supinae Euphorbia maculata L..Nature and flavor are hot, and are flat.Return liver, large intestine channel.But the merit heat-clearing and toxic substances removing, cooling blood for hemostasis.
Composition principle: the described aplastic anemia of modern medicine belongs to the categories such as the traditional Chinese medical science " asthenia ", " blood disorder ", " warm ".The QI and blood of human body derives from each precise and tiny and essence in kidney of taste water.Insufficiency of the spleen biochemistry is had no right, and then marrow does not fill; The vital essence of suffering from a deficiency of the kidney loss, then the blood source is not filled.The spleen kidneys that adopt are ruled together more, but the medication of present clinical Chinese traditional treatment aplastic anemia biases toward the invigorating the spleen and replenishing QI hemopoietic more, but actual spleen kidney two thanks to is this, multiple susceptible heresy (comprising poison heresy, radioactive substance, medicine etc.) is mark, and continuing then affects the heart, liver, QI and blood, the further virtual loss of marrow, blood is unable, leads blood stasis.Control and work as strengthening spleen, tonifying kidney, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, rather than enriching blood simply.The present invention adopts Radix Astragali invigorating QI to consolidate the body surface resistance, Cacumen Securinegae Suffruticosae expelling wind and activating blood circulation, the strong muscle of kidney tonifying, this two medicine all be mend in interior drive in outside, reinforcement and elimination in combination; Rhizoma Polygonati boosting qi and nourishing yin, spleen invigorating lung moistening kidney tonifying, the Fructus Ligustri Lucidi nourishing the liver and kidney, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, Chinese angelica blood supplementing is invigorated blood circulation, and helps altogether the source of hemopoietic; Nine layers of wind have again the merit of invigorating blood circulation in enriching blood, the Herba Euphorbiae Humifusae heat-clearing and toxic substances removing, and cooling blood for hemostasis, Cornu Bovis seu Bubali cheek hemostasis, this three blood medicine is opened the running that promotes haematogenous mechanism between entire, the phlegm and toxin stasis that also can prevent Transfusion to cause.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: Radix Astragali 6g, Rhizoma Polygonati 8g, Fructus Ligustri Lucidi 8g, Cacumen Securinegae Suffruticosae 6g, Cornu Bovis seu Bubali cheek 6g, Rhizoma Atractylodis Macrocephalae 8g, Radix Angelicae Sinensis 6g, nine layers of wind 8g, Herba Euphorbiae Humifusae 3g.
Embodiment 2, the crude drug weight proportion: Radix Astragali 10g, Rhizoma Polygonati 15g, Fructus Ligustri Lucidi 15g, Cacumen Securinegae Suffruticosae 10g, Cornu Bovis seu Bubali cheek 10g, Rhizoma Atractylodis Macrocephalae 15g, Radix Angelicae Sinensis 10g, nine layers of wind 15g, Herba Euphorbiae Humifusae 6g.
Embodiment 3, the crude drug weight proportion: Radix Astragali 8g, Rhizoma Polygonati 10g, Fructus Ligustri Lucidi 10g, Cacumen Securinegae Suffruticosae 8g, Cornu Bovis seu Bubali cheek 8g, Rhizoma Atractylodis Macrocephalae 10g, Radix Angelicae Sinensis 8g, nine layers of wind 10g, Herba Euphorbiae Humifusae 5g.
During use, Chinese medicine astragalus of the present invention, Rhizoma Polygonati, Fructus Ligustri Lucidi, Cacumen Securinegae Suffruticosae, the Cornu Bovis seu Bubali cheek, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Herba Euphorbiae Humifusae and nine layers of wind are decocted with water twice, merging filtrate, a minute morning and evening takes.
Effective combination of said medicine is coordinated mutually, can effectively reach the purpose for the treatment of aplastic anemia, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows, and wherein drugs uses and is the crude drug weight proportion among the embodiment 3.
1 object and method.
1.1 object: the CAA patient that all cases all derive from July, 2010～2011 year December hematology outpatient service, are in hospital, totally 82 examples.
1.2 method.
1.2.1 grouping: treatment group 42 examples, male's 24 examples wherein, women's 18 examples, 15～69 years old age, average (36.5 ± 14.7) year; Matched group 40 examples, male's 25 examples wherein, women's 15 examples, 12～70 years old age, average (37.2 ± 15.5) year.The physical data such as two groups of Genders, age are no difference of science of statistics relatively.
1.2.2 Therapeutic Method: the oral stanozolol sheet of matched group (Pharmaceutical Group Co.,Ltd of Nanning Baihui, the accurate word H45020728 of traditional Chinese medicines) treatment, each 2 ~ 4mg, 3 times/d.Treatment group adds the embodiment of the invention 3 gained Chinese medicine decoction, 2 times/d on the matched group basis.Be 6 months two groups of courses for the treatment of.
1.2.3 observation index: two groups all take 6 months as 1 course for the treatment of, in the therapeutic process main observe the patient weak, breathe hard, the ordinary circumstance such as hemorrhage, blood transfusion number of times and time, liver function and hemogram (comprising leukocyte, hemoglobin, platelet count), bone marrow smear change, and estimate its curative effect.
1.2.4 curative effect determinate standard: with reference to the 4th standard that the aplastic anemia meeting is drafted in 1987, produce effects: anemia, bleeding disappeared hemoglobin male 120g/L, women 100g/L, leukocyte 4.0 * 10
9/ L, platelet 80 * 10
9More than/the L, follow up a case by regular visits to 1 year without the recidivist.Effectively: anemia, bleeding disappear hemoglobin male 120g/L, women 100g/L, leukocyte 3.5 * 10
9About/L, platelet has to a certain degree to be recovered, and follows up a case by regular visits to 3 months stable disease or continues improvement person.Invalid: as can not to reach obvious progressive person through abundant treatment.
1.2.5 statistical analysis carries out statistical analysis with SPSS 13.0, P＜0.05 expression has significant.
2 results.
2.1 the curative effect of two groups of cases relatively: see the following form, obvious effective rate and total effective rate treatment group obviously are better than matched group (P＜0.05).
2.2 two groups of untoward reaction relatively: have 7 examples the transaminase to occur in matched group 40 examples and raise (17.5%), the diseases (32.5%) such as acne, hirsutism, hoarseness in various degree appear in 13 examples.Do not occur above-mentioned untoward reaction in the treatment group, other systems inspection is not also found obviously unusual.
3. conclusion.
The demonstration of this result of study, the present invention treats the aplastic anemia determined curative effect, and adverse reaction rate is low, is worthy of promotion and application.
Claims (2)
1. medicine for the treatment of aplastic anemia, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of the Radixs Astragali, 8 ~ 15 parts of Rhizoma Polygonatis, 6 ~ 10 parts of 8 ~ 15 parts of Cacumen Securinegae Suffruticosaes of Fructus Ligustri Lucidi, 6 ~ 10 parts on the Cornu Bovis seu Bubali cheek, 8 ~ 15 parts of the Rhizoma Atractylodis Macrocephalaes, 6 ~ 10 parts of Radix Angelicae Sinensis, 8 ~ 15 parts of nine layers of wind, 3 ~ 6 parts of Herba Euphorbiae Humifusaes.
2. a kind of medicine for the treatment of aplastic anemia according to claim 1 is characterized in that its weight proportion is: 8 parts of the Radixs Astragali, 10 parts of Rhizoma Polygonatis, 8 parts of 10 parts of Cacumen Securinegae Suffruticosaes of Fructus Ligustri Lucidi, 8 parts on the Cornu Bovis seu Bubali cheek, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Radix Angelicae Sinensis, 10 parts of nine layers of wind, 5 parts of Herba Euphorbiae Humifusaes.
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