CN106039039A - Aplastic anemia treating traditional Chinese medicine preparation and preparation method thereof - Google Patents

Aplastic anemia treating traditional Chinese medicine preparation and preparation method thereof Download PDF

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CN106039039A
CN106039039A CN201610694813.4A CN201610694813A CN106039039A CN 106039039 A CN106039039 A CN 106039039A CN 201610694813 A CN201610694813 A CN 201610694813A CN 106039039 A CN106039039 A CN 106039039A
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chinese medicine
aplastic anemia
medicine preparation
herba
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李运斌
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Abstract

The invention discloses an aplastic anemia treating traditional Chinese medicine preparation, which is prepared from the following raw materials by weight: 10-20 parts of milkvetch root, 6-14 parts of hawthorn leaf, 3-10 parts of aspongopus chinensis dallas, 3-10 parts of daemonorops draco, 10-20 parts of taxillus sutchuenensis (lecomte) danser, 10-20 parts of cynomorium songaricum rupr, 10-20 parts of twig of winged euonymus, 10-20 parts of caulis spatholobi, 6-14 parts of dendrobium, 6-14 parts of eucommia ulmoides, 10-20 parts of atractylodes macrocephala, and 10-20 parts of folium isatidis. The invention further discloses a preparation method of the aplastic anemia treating traditional Chinese medicine preparation. According to the present invention, the formula of the traditional Chinese medicine has the characteristic of dialectical compatibility, the manifestation and the root cause of the aplastic anemia are treated, the total effective rate achieves 96.5%, and the aplastic anemia treating traditional Chinese medicine preparation has characteristics of significant treatment effect, recurrence resistance, low toxic-side effect, short treatment course, and wide clinical application value.

Description

A kind of Chinese medicine preparation treating aplastic anemia and preparation method thereof
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation treating aplastic anemia and system thereof Preparation Method.
Background technology
Aplastic anemia is called for short aplastic anemia, is a kind of hemopoietic function of bone marrow caused by the factor such as biology, chemistry, physics Going down or exhaustion, the intractable hematopathy being characterized with hematopoietic stem cell injuries, peripheral blood pancytopenia, is hemopoietic system Relatively common disease.It mainly shows as hemopoietic hypofunction of marrow, pancytopenia and anemia, hemorrhage, infection.Although Each age group all can be fallen ill, but common with person between twenty and fifty, and male is more than women, and the north is more than south.Treat aregeneratory at present Property anemia doctor trained in Western medicine treat with immunosuppressant, glucocorticoid, androgen and blood transfusion etc., although some patients can respite Symptom, but the most repeatedly, therapeutic effect is undesirable.And drug price used is high, side effect is big, and long-term taking immunosuppressant can Cause Liver and kidney function infringement and gastral untoward reaction.
The traditional Chinese medical science is by categories such as aplastic anemia ownership " asthenia ", " blood disorder ", " warms ", and in treatment, many employing spleen kidneys are same Control, it may have preferably curative effect, effective percentage is at 60%-90%, and side effect is little, and the most of patients state of an illness can significantly be changed Kind, but in curative effect, there is bottleneck sometimes, the most preferably break through this limitation, improve the clinic of Kidney-Nourishing to a greater extent Curative effect, is our emphasis place of now and from now on studying.It practice, spleen kidney two loses as originally, multiple susceptible heresy (includes that poison is evil, puts Penetrating property material, medicine etc.) for marking, continue, affect the heart, liver, QI and blood, the further virtual loss of marrow, blood is unable, leads blood stasis.Control when strong Spleen the kidney invigorating, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling rather than enriching blood simply.
Summary of the invention
Can not thoroughly effect a radical cure aplastic anemia for medicine of the prior art, the most repeatedly, therapeutic effect is the most very managed The present situation thought, the invention provides a kind of evident in efficacy, Chinese medicine preparation for the treatment of aplastic anemia of having no side effect and Its preparation method.
For realizing object above, the present invention is achieved by the following technical programs:
A kind of Chinese medicine preparation treating aplastic anemia, is made up of the raw material of following weight portion: Radix Astragali 10-20 part, Folium Crataegi 6-14 part, Aspongopus 3-10 part, Sanguis Draxonis 3-10 part, Herba Taxilli 10-20 part, Herba Cynomorii 10-20 part, Ramulus Euonymi 10-20 part, Caulis Spatholobi 10-20 part, Herba Dendrobii 6-14 part, Cortex Eucommiae 6-14 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Folium Isatidis 10-20 part.
Preferably, be made up of the raw material of following weight portion: Radix Astragali 12-17 part, Folium Crataegi 8-11 part, Aspongopus 6-10 part, Sanguis Draxonis 6-10 part, Herba Taxilli 10-15 part, Herba Cynomorii 10-15 part, Ramulus Euonymi 10-15 part, Caulis Spatholobi 10-15 part, Herba Dendrobii 8-12 part, Cortex Eucommiae 8-12 part, Rhizoma Atractylodis Macrocephalae 12-17 part, Folium Isatidis 12-17 part.
Preferably, be made up of the raw material of following weight portion: the Radix Astragali 15 parts, Folium Crataegi 10 parts, Aspongopus 8 parts, Sanguis Draxonis 8 parts, Herba Taxilli 12 parts, Herba Cynomorii 13 parts, Ramulus Euonymi 15 parts, Caulis Spatholobi 12 parts, Herba Dendrobii 10 parts, the Cortex Eucommiae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Folium Isatidis 15 Part.
The preparation method of the Chinese medicine preparation for the treatment of aplastic anemia, step is as follows: weigh each raw material Chinese medicine in proportion, Adding the soak by water of the quality of medicinal material of 4-7 times, decoct 2 times, each 1-2h, merging decoction liquor and medicinal residues, in hermetically sealed can, seal It is filtered to remove medicinal residues after preserving 2-3d, to obtain final product.
In the present invention, each raw material herbal function is as follows:
The Radix Astragali: slightly warm in nature, sweet in the mouth, return spleen channel, lung meridian, invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, granulation promoting.
Folium Crataegi: property is put down, sour in the mouth is returned Liver Channel, blood circulation promoting and blood stasis dispelling, is regulated the flow of vital energy and promote blood circulation, change turbid blood fat reducing, for qi depression to blood stasis, the thoracic obstruction Pained, chest distress, palpitation and amnesia, vertigo and tinnitus, hyperlipemia.
Aspongopus: warm in nature is acrid in the mouth, salty.Return Liver Channel, spleen channel, kidney channel, promoting the circulation of QI to relieve pain, warming the kidney to invigorate YANG.
Sanguis Draxonis: property is put down, sweet in the mouth, salty.GUIXIN warp, Liver Channel, removing blood stasis and relieving pain, hemostasia and promoting granulation, with controlling traumatic injury, the internal injury stasis of blood Bitterly, continuous bleeding due to traumatic injury.
Herba Taxilli: bitter in the mouth, sweet, property is put down.Return Liver Channel, kidney channel, invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling.
Herba Cynomorii: warm in nature, sweet in the mouth, return spleen channel, kidney channel, large intestine channel, kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation, the modern times are usually used in controlling Treat idiopathic thrombocytopenic purpura.
Ramulus Euonymi: cold in nature, bitter in the mouth.Returning Liver Channel, spleen channel, promoting the circulation of blood is stimulated the menstrual flow, eliminating stasis to stop pain, with controlling menoxenia, postnatal blood stasis Stomachache, traumatic injury swell and ache, abdominal pain due to worm stagnation.
Caulis Spatholobi: warm in nature, bitter in the mouth, sweet.Return Liver Channel, kidney channel, enrich blood, invigorate blood circulation, dredging collateral, with control menoxenia, blood deficiency and yellow complexion, Paralysis and numbness, rheumatic arthralgia.
Herba Dendrobii: cold nature, sweet in the mouth, return stomach warp, kidney channel, reinforcing stomach reg fluid, nourishing YIN and clearing away heat.
The Cortex Eucommiae: warm in nature, sweet in the mouth.Return Liver Channel, kidney channel, invigorating the liver and kidney, bone and muscle strengthening, antiabortive, with control lumbago due to renal deficiency, muscles and bones unable, Blood leaking in gestation, frequent fetal movement, vascular hypertension.
The Rhizoma Atractylodis Macrocephalae: warm in nature, sweet in the mouth, hardship, return spleen channel, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic.
Folium Isatidis: cold in nature, bitter in the mouth, GUIXIN warp, stomach warp, the clear speckle of heat-clearing and toxic substances removing, removing heat from blood.
The method have the benefit that the present invention with strengthening spleen, tonifying kidney for this, hold concurrently enrich blood with heat-clearing and toxic substances removing, replenishing essence, blood circulation promoting and blood stasis dispelling, receipts Holding back the method for the treatment of of hemostasis, dialectical compatibility Chinese medicine formula, for aplastic anemia treating both the principal and secondary aspects of a disease, total effective rate reaches 96.5%, treats Effect is notable, is difficult to recurrence, and toxic and side effects is little, short treating period, has wide clinical value.
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below in conjunction with the embodiment of the present invention, Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one Divide embodiment rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making The every other embodiment obtained under creative work premise, broadly falls into the scope of protection of the invention.
Embodiment 1:
A kind of Chinese medicine preparation treating aplastic anemia, is made up of the raw material of following weight portion: the Radix Astragali 15 parts, Fructus Crataegi 10 parts of leaf, Aspongopus 8 parts, Sanguis Draxonis 8 parts, Herba Taxilli 12 parts, Herba Cynomorii 13 parts, Ramulus Euonymi 15 parts, Caulis Spatholobi 12 parts, Herba Dendrobii 10 parts, The Cortex Eucommiae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Folium Isatidis 15 parts.
The preparation method of the Chinese medicine preparation for the treatment of aplastic anemia, step is as follows: weigh each raw material Chinese medicine in proportion, Boiling 2 times, adds the soak by water 2h of 6 times of original quality of medicinal materials for the first time, and second time adds the water of 4 times of original quality of medicinal materials Decocting 1.5h, merging decoction liquor and medicinal residues, in hermetically sealed can, seal and are filtered to remove medicinal residues after preserving 3d, to obtain final product.
Embodiment 2:
A kind of Chinese medicine preparation treating aplastic anemia, is made up of the raw material of following weight portion: the Radix Astragali 14 parts, Fructus Crataegi 8 parts of leaf, Aspongopus 7 parts, Sanguis Draxonis 7 parts, Herba Taxilli 12 parts, Herba Cynomorii 15 parts, Ramulus Euonymi 12 parts, Caulis Spatholobi 14 parts, Herba Dendrobii 9 parts, Du Secondary 10 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Folium Isatidis 13 parts.
The preparation method of the Chinese medicine preparation for the treatment of aplastic anemia, step is as follows: weigh each raw material Chinese medicine in proportion, Boiling 2 times, adds the soak by water 1.5h of 5 times of original quality of medicinal materials for the first time, and second time adds 4 times of original quality of medicinal materials Soak by water 1.5h, merging decoction liquor and medicinal residues, in hermetically sealed can, seal and are filtered to remove medicinal residues after preserving 3d, to obtain final product.
Embodiment 3:
A kind of Chinese medicine preparation treating aplastic anemia, is made up of the raw material of following weight portion: the Radix Astragali 12 parts, Fructus Crataegi 11 parts of leaf, Aspongopus 6 parts, Sanguis Draxonis 10 parts, Herba Taxilli 10 parts, Herba Cynomorii 15 parts, Ramulus Euonymi 10 parts, Caulis Spatholobi 15 parts, Herba Dendrobii 8 parts, The Cortex Eucommiae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Folium Isatidis 17 parts.
The preparation method of the Chinese medicine preparation for the treatment of aplastic anemia, step is as follows: weigh each raw material Chinese medicine in proportion, Boiling 2 times, adds the soak by water 2h of 7 times of original quality of medicinal materials for the first time, and second time adds the water of 4 times of original quality of medicinal materials Decocting 2h, merging decoction liquor and medicinal residues, in hermetically sealed can, seal and are filtered to remove medicinal residues after preserving 2d, to obtain final product.
Embodiment 4:
A kind of Chinese medicine preparation treating aplastic anemia, is made up of the raw material of following weight portion: the Radix Astragali 17 parts, Fructus Crataegi 8 parts of leaf, Aspongopus 10 parts, Sanguis Draxonis 6 parts, Herba Taxilli 15 parts, Herba Cynomorii 10 parts, Ramulus Euonymi 15 parts, Caulis Spatholobi 10 parts, Herba Dendrobii 12 parts, The Cortex Eucommiae 8 parts, the Rhizoma Atractylodis Macrocephalae 17 parts, Folium Isatidis 12 parts.
The preparation method of the Chinese medicine preparation for the treatment of aplastic anemia, step is as follows: weigh each raw material Chinese medicine in proportion, Boiling 2 times, adds the soak by water 2h of 5 times of original quality of medicinal materials for the first time, and second time adds the water of 5 times of original quality of medicinal materials Decocting 1h, merging decoction liquor and medicinal residues, in hermetically sealed can, seal and are filtered to remove medicinal residues after preserving 3d, to obtain final product.
Embodiment 5:
A kind of Chinese medicine preparation treating aplastic anemia, is made up of the raw material of following weight portion: the Radix Astragali 10 parts, Fructus Crataegi 14 parts of leaf, Aspongopus 3 parts, Sanguis Draxonis 10 parts, Herba Taxilli 10 parts, Herba Cynomorii 20 parts, Ramulus Euonymi 10 parts, Caulis Spatholobi 20 parts, Herba Dendrobii 6 parts, The Cortex Eucommiae 14 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Folium Isatidis 20 parts.
The preparation method of the Chinese medicine preparation for the treatment of aplastic anemia, step is as follows: weigh each raw material Chinese medicine in proportion, Boiling 2 times, adds the soak by water 2h of 6 times of original quality of medicinal materials for the first time, and second time adds the water of 6 times of original quality of medicinal materials Decocting 2h, merging decoction liquor and medicinal residues, in hermetically sealed can, seal and are filtered to remove medicinal residues after preserving 2d, to obtain final product.
Embodiment 6:
A kind of Chinese medicine preparation treating aplastic anemia, is made up of the raw material of following weight portion: the Radix Astragali 20 parts, Fructus Crataegi 6 parts of leaf, Aspongopus 10 parts, Sanguis Draxonis 3 parts, Herba Taxilli 20 parts, Herba Cynomorii 10 parts, Ramulus Euonymi 20 parts, Caulis Spatholobi 10 parts, Herba Dendrobii 14 parts, The Cortex Eucommiae 6 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Folium Isatidis 10 parts.
The preparation method of the Chinese medicine preparation for the treatment of aplastic anemia, step is as follows: weigh each raw material Chinese medicine in proportion, Boiling 2 times, adds the soak by water 2h of 6 times of original quality of medicinal materials for the first time, and second time adds the water of 4 times of original quality of medicinal materials Decocting 1.5h, merging decoction liquor and medicinal residues, in hermetically sealed can, seal and are filtered to remove medicinal residues after preserving 3d, to obtain final product.
The positive effect of the present invention is further illustrated below in conjunction with clinic:
Case selection: select Patients with Aplastic Anemia 170 example made a definite diagnosis, wherein male 92 example, women 78 example, age In 24-65 year, the mean age is 46 years old.
1, diagnostic criteria:
1. pancytopenia, reticulocyte absolute value reduces, and percentage of lymphocyte increases；2. general without splenomegaly； 3. bone marrow examination shows that (such as active proliferation, megalokaryocyte should significantly reduce, bone marrow at least one position hypoplasia or severe attenuating Granule composition should being shown in, non-hematopoietic cell increases)；4. can except cause the other diseases such as paroxysmal of pancytopenia to sleep Refractory anemia in property hemoglobinuria, myelodysplastic syndrome, acute aplastic crisis, myelofibrosis, Acute leukemia, malignant histocytosis etc.；5. general anti-anemia action medicine is failed to respond to any medical treatment.
2, Therapeutic Method: according to the formula proportion in embodiment 1, takes Radix Astragali 15g, Folium Crataegi 10g, Aspongopus 8g, Sanguis Draxonis 8g, Herba Taxilli 12g, Herba Cynomorii 13g, Ramulus Euonymi 15g, Caulis Spatholobi 12g, Herba Dendrobii 10g, Cortex Eucommiae 10g, Rhizoma Atractylodis Macrocephalae 15g, Folium Isatidis 15g, mixed Closing, pulverize, boiling 2 times, add the soak by water 2h of 6 times of original quality of medicinal materials for the first time, second time adds 4 times of original medical materials The soak by water 1.5h of quality, merging decoction liquor and medicinal residues are in hermetically sealed can, and sealing is filtered to remove medicinal residues after preserving 3d, obtains decoct, Point early, secondary drink in evening, within 7 days, be 1 course for the treatment of, treatment cycle 6 course for the treatment of.
3, Outcome measure:
1. recovery from illness: anemia, bleeding disappear, hemoglobin reaches man 120g/l, the above leukocyte of female 100g/l 4.0x109/l；Platelet reaches 8.0 ten thousand/more than l, follows up a case by regular visits to more than 1 year without recurrence；
The most effective: anemia, bleeding disappear, hemoglobin reaches man 120g/l, female 100g/l, leukocyte 3.5x109/ About l, platelet also has degree to recover, and follows up a case by regular visits to three months stable disease or continues progress person；
The most effective: anemia, bleeding are clearly better, and do not transfuse blood, in hemoglobin is relatively treated first 1 month, modal value increases More than 30g/l, and maintain do not decline for 3 months；
The most invalid: after fully treatment, symptom, hemogram can not reach the person that substantially do not improves.
4, therapeutic effect: 122 examples of fully recovering in experimental group 170 example, effective 28 examples, effective 14 examples, invalid 6 examples, total effective rate Reach 96.5%.Aplastic anemia can effectively be treated by the medicine of the present invention.
5, model case:
Case 1: autumn, man, 51 years old, suffer from more than 2 years of aplastic anemia, dizziness is breathed hard, and with pale complexion, god The symptoms such as tired power, insomnia and dreamful sleep, take 3 courses for the treatment of of Chinese medicine preparation of the embodiment of the present invention 1, and spirit takes a turn for the better, and can pacify night and sleep；Continue Continuing and take 3 courses for the treatment of, all diseases disappear, and recovery from illness follows up a case by regular visits to after half a year have no recurrence.
Case 2: river, female, 32 years old.Because of shortness of breath and palpitation, dizzy weak, inappetence, lassitude, pale complexion, under The symptoms such as the slight edema of limb go to hospital therapy, through bone marrow aspiration inspection, are diagnosed as aplastic anemia, take the present invention real Executing 2 courses for the treatment of of Chinese medicine preparation of example 1, readme symptom has clear improvement, and continues to take 3 courses for the treatment of, and all diseases disappear, routine blood test and bone Marrow checks all normal, cures.
Above example only in order to technical scheme to be described, is not intended to limit；Although with reference to previous embodiment The present invention is described in detail, it will be understood by those within the art that: it still can be to aforementioned each enforcement Technical scheme described in example is modified, or wherein portion of techniques feature is carried out equivalent；And these amendment or Replace, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.

Claims (4)

1. the Chinese medicine preparation treating aplastic anemia, it is characterised in that be made up of the raw material of following weight portion: the Radix Astragali 10-20 part, Folium Crataegi 6-14 part, Aspongopus 3-10 part, Sanguis Draxonis 3-10 part, Herba Taxilli 10-20 part, Herba Cynomorii 10-20 part, Ramulus Euonymi 10-20 part, Caulis Spatholobi 10-20 part, Herba Dendrobii 6-14 part, Cortex Eucommiae 6-14 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Folium Isatidis 10-20 part.
2. the Chinese medicine preparation treating aplastic anemia as claimed in claim 1, it is characterised in that by following weight portion Raw material is made: Radix Astragali 12-17 part, Folium Crataegi 8-11 part, Aspongopus 6-10 part, Sanguis Draxonis 6-10 part, Herba Taxilli 10-15 part, Herba Cynomorii 10-15 part, Ramulus Euonymi 10-15 part, Caulis Spatholobi 10-15 part, Herba Dendrobii 8-12 part, Cortex Eucommiae 8-12 part, Rhizoma Atractylodis Macrocephalae 12-17 part, Folium Isatidis 12-17 part.
3. the Chinese medicine preparation treating aplastic anemia as claimed in claim 2, it is characterised in that by following weight portion Raw material is made: the Radix Astragali 15 parts, Folium Crataegi 10 parts, Aspongopus 8 parts, Sanguis Draxonis 8 parts, Herba Taxilli 12 parts, Herba Cynomorii 13 parts, Ramulus Euonymi 15 Part, Caulis Spatholobi 12 parts, Herba Dendrobii 10 parts, the Cortex Eucommiae 10 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Folium Isatidis 15 parts.
4. the preparation method of the Chinese medicine preparation of the treatment aplastic anemia as described in claim 1-3 is arbitrary, its feature exists In, step is as follows: weigh each raw material Chinese medicine in proportion, adds the soak by water of the quality of medicinal material of 4-7 times, decocts 2 times, each 1- 2h, merging decoction liquor and medicinal residues, in hermetically sealed can, seal and are filtered to remove medicinal residues after preserving 2-3d, to obtain final product.
CN201610694813.4A 2016-08-18 2016-08-18 Aplastic anemia treating traditional Chinese medicine preparation and preparation method thereof Pending CN106039039A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102727749A (en) * 2012-07-06 2012-10-17 刘加强 Medicine for treating aplastic anemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102727749A (en) * 2012-07-06 2012-10-17 刘加强 Medicine for treating aplastic anemia

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
梁启成等: "《中国壮药学》", 31 May 2005, 广西民族出版社 *
胡郁坤等: "《中医单方全书（珍藏本）超值版》", 30 June 2012, 湖南科学技术出版社 *

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