CN108635389A - A kind of preparation method of Chinese medicine preparation and its electuary that treating diabetes B - Google Patents
A kind of preparation method of Chinese medicine preparation and its electuary that treating diabetes B Download PDFInfo
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Abstract
The invention discloses a kind of preparation methods of Chinese medicine preparation and its electuary that treating diabetes B, formula reduces blood glucose by the active ingredient in monarch drug in a prescription ginseng and Inonotus obliquus and restores patient body function, pass through the cooperation of ministerial drug again, alleviate diabetic disorders, increase the immunity and cell activity of human body, enough recovery β cell functions are enabled a patient to, diabetes are fundamentally cured；Preparation method carries out the extraction of two methods for the physical characteristic of the active ingredient in Inonotus obliquus, and ginseng is made powder and is mixed into electuary, improves the utilization rate of valuable ingredient of traditional Chinese medicine.
Description
Technical field
The present invention relates to the field of Chinese medicines, especially a kind of preparation side of Chinese medicine preparation and its electuary that treating diabetes B
Method.
Background technology
Diabetes B is a kind of incretion metabolism disease, has genetic predisposition, it is thin that main pathogenesis is related to pancreas islet β
Born of the same parents' dysfunction (enough insulin cannot be secreted), peripheral insulin resistance etc..35-40 Sui be the disease Susceptible population.Root
According to clinical research, it is exactly islet beta cell function obstacle to lead to the core mechanism that diabetes B is fallen ill.Islet beta cell function is blood
Glycoregulatory core, protection, raising, improvement, recovery β cell functions are the basic of link diabetes development.Protect β cell functions
Method include：High sugar/high Fatty toxicity is released, β cells is reduced and secretes load, promotes Beta cell proliferation, regeneration, reparation, divide again
Change, reduces β Apoptosis；Related drug, including intensive insulin therapy, GLP-1, thiazolidinediones, ACEI, ARB etc., but
These drugs often just start application after diabetes diagnosis.Currently, not being directly targeted the special efficacy for islet cells intervention still
Drug or preventative vaccine, the clinical strategy for mainly taking symptomatic treatment.
It is clinically directed in the medicine of diabetes B pathogenesis at present, has the diformazan for improving insulin resistance double
Guanidine, glitazone have Insulin secretagogues sulfonylureas, meglitinide, there is the α glucuroides for inhibiting gastrointestinal tract glucose absorption
Inhibitor, also incretin class hypoglycemic medicine such as 1 analog of glucagon sample polypeptide or its receptor stimulating agent, DDP- IV press down
Preparation, insulin.But these drugs all cannot effectively contain the chronic failure of diabetes B patient's β cell functions, the state of an illness into
Exhibition, market needs one kind that can have dual regulation to human body glycometabolism, can restore the drug of β cell functions.
Invention content
To solve the deficiencies in the prior art, the purpose of the present invention is to provide a kind of Chinese medicine preparations for treating diabetes B
And its preparation method of electuary, blood glucose is reduced by the active ingredient in monarch drug in a prescription ginseng and Inonotus obliquus and restores patient body work(
Can, then by the cooperation of ministerial drug, alleviate diabetic disorders, increase the immunity and cell activity of human body so that patient can be extensive
Multiple β cell functions.
In order to realize that above-mentioned target, the present invention adopt the following technical scheme that：
A kind of Chinese medicine preparation for treating diabetes B includes according to mass fraction：Ginseng 20-40, Inonotus obliquus 60-80.
A kind of Chinese medicine preparation for treating diabetes B above-mentioned includes according to mass fraction：Ginseng 20-40, Inonotus obliquus
60-80, prepared rehmannia root 39-53, raspberry 48-64, pueraria lobata 26-44, Schisandra chinensis 10-22, Radix Astragali 18-30, Fructus Forsythiae 21-29.
A kind of Chinese medicine preparation for treating diabetes B above-mentioned includes according to mass fraction：Ginseng 30, Inonotus obliquus 70,
Prepared rehmannia root 46, raspberry 56, pueraria lobata 35, Schisandra chinensis 16, Radix Astragali 24, Fructus Forsythiae 25.
A kind of preparation method of instant particles as Chinese medicine that treating diabetes B, includes the following steps：
Step 1 captures following medicinal material according to mass fraction respectively：Ginseng 20-40, Inonotus obliquus 60-80, prepared rehmannia root
39-53, raspberry 48-64, pueraria lobata 26-44, Schisandra chinensis 10-22, Radix Astragali 18-30, Fructus Forsythiae 21-29；
Inonotus obliquus is made powder, respectively obtains water-soluble extractive and ethanol extract by step 2；
Ginseng is dried under reduced pressure by step 3 at 60-80 DEG C, and dried object smashes it through 80 mesh sieve, obtains Ginseng Root Powder；
Step 4, by prepared rehmannia root, raspberry, pueraria lobata, Schisandra chinensis, Radix Astragali adds boiling after Fructus Forsythiae is impregnated 48 hours with ethyl alcohol
1 hour is boiled, filter residue and filtrate are detached；
Step 5 adds water-soluble extractive and ethanol extract that step 2 obtains after the cooling of the filtrate of step 3
In the filtrate for entering step 3, stirs 30 minutes, obtain preliminary mixed liquor, then the Ginseng Root Powder that step 2 obtains is added to tentatively
In mixed liquor, a hour is stirred, final Chinese medicine mixed liquor is obtained；
Step 6 is added auxiliary material in final Chinese medicine mixed liquor, stirs evenly, and is granulated, and pack obtains electuary.
A kind of preparation method of instant particles as Chinese medicine for treating diabetes B above-mentioned, the extracting method of water-soluble extractive are：
Be soaked in water Inonotus obliquus powder, soak at room temperature, after 24 hours, after boiling 15 minutes, and separating filtrate and filter residue；Filtrate is passed through
Abstraction technique obtains water-soluble extractive.
A kind of preparation method of instant particles as Chinese medicine for treating diabetes B above-mentioned, the extracting method of ethanol extract are：It will
The filter residue obtained after boiling is boiled, is placed in ethyl alcohol 70 degrees Celsius of heated at constant temperature 30 minutes, separating filtrate and filter residue；It will filter
Liquid obtains ethanol extract by abstraction technique.
A kind of preparation method of instant particles as Chinese medicine for treating diabetes B above-mentioned, the medicinal material of prepared rehmannia root is before immersion is to boil water
First use ginger frying.
A kind of preparation method of instant particles as Chinese medicine for treating diabetes B above-mentioned, auxiliary material include according to mass percent：
58%-65% sorbierites, 35%-42% glycine betaines.
The invention has the beneficial effects that：
Rd, Re, Rf, panaxan, ginseng polypeptide in ginseng all have apparent hypoglycemic effect, for human body glycometabolism
There is clearly bi-directional adjustment effect；
Inonotus obliquus is extracted two kinds of aqueous extract and alcohol extract by the present invention respectively, has solubization more in aqueous extract
Sugar, callose ingredient have water-insoluble polysaccharide and oleanolic acid triterpene class compound in alcohol extract；Polysaccharide, either
Water-soluble polysaccharide or water-insoluble polysaccharide all have the function of that apparent hypoglycemic, callose possess high SOD activity, no
The ability that human body removes a variety of reactive oxygen free radicals only can be effectively promoted, and the anti-oxidant system in human body can also be restored
System enhances antioxidant ability of organism；Oleanolic acid triterpene class compound, which has, mitigates hepatic injury, improves the effect of body immunity
Fruit；
Blood glucose is reduced by the active ingredient in monarch drug in a prescription ginseng and Inonotus obliquus and restores patient body function, then passes through minister
The cooperation of medicine alleviates diabetic disorders, increases the immunity and cell activity of human body so that patient can restore β cell functions；
The sorbierite and glycine betaine that the auxiliary material of electuary uses adapt to diabetic.
Specific implementation mode
Specific introduce is made to the present invention below in conjunction with specific embodiment.
A kind of Chinese medicine preparation for treating diabetes B includes according to mass fraction：Ginseng 20-40, Inonotus obliquus 60-80.
In order to improve therapeutic effect, a kind of Chinese medicine preparation for treating diabetes B includes according to mass fraction：Ginseng 20-
40, Inonotus obliquus 60-80, prepared rehmannia root 39-53, raspberry 48-64, pueraria lobata 26-44, Schisandra chinensis 10-22, Radix Astragali 18-30, Fructus Forsythiae
21-29。
A kind of preparation method of instant particles as Chinese medicine that treating diabetes B, includes the following steps：
Step 1 captures medicinal material as requested respectively：As a preferred embodiment, the medicinal material of prepared rehmannia root is first adopted before immersion is to boil water
With ginger frying, such prepared rehmannia root will not injure one's stomach.
Inonotus obliquus is made powder, respectively obtains water-soluble extractive and ethanol extract by step 2；
The extracting method of water-soluble extractive is：Be soaked in water Inonotus obliquus powder, and soak at room temperature boils after 24 hours
After 15 minutes, separating filtrate and filter residue；Filtrate is obtained into water-soluble extractive by abstraction technique；
The extracting method of ethanol extract is：The filter residue that will be obtained after boiling is boiled is placed in ethyl alcohol 70 degrees Celsius
Heated at constant temperature 30 minutes, separating filtrate and filter residue；Filtrate is obtained into ethanol extract by abstraction technique.
Ginseng is dried under reduced pressure by step 3 at 60-80 DEG C, and dried object smashes it through 80 mesh sieve, obtains Ginseng Root Powder；
Step 4, by prepared rehmannia root, raspberry, pueraria lobata, Schisandra chinensis, Radix Astragali adds boiling after Fructus Forsythiae is impregnated 48 hours with ethyl alcohol
1 hour is boiled, filter residue and filtrate are detached；
Step 5 adds water-soluble extractive and ethanol extract that step 2 obtains after the cooling of the filtrate of step 3
In the filtrate for entering step 3, stirs 30 minutes, obtain preliminary mixed liquor, then the Ginseng Root Powder that step 2 obtains is added to tentatively
In mixed liquor, a hour is stirred, final Chinese medicine mixed liquor is obtained；
Step 6 is added auxiliary material in final Chinese medicine mixed liquor, stirs evenly, and is granulated, and pack obtains electuary；As one
Kind is preferred, and auxiliary material includes according to mass percent：58%-65% sorbierites, 35%-42% glycine betaines are avoided using routine
The product of the product or high sugar content made of starch such as dextrin.
Pharmacology analysis：
Rd, Re, Rf, panaxan, ginseng polypeptide in ginseng all have apparent hypoglycemic effect, for human body glycometabolism
There is clearly bi-directional adjustment effect.
Active ingredient polysaccharide in Inonotus obliquus, either water-soluble polysaccharide or water-insoluble polysaccharide all have apparent drop
The effect of sugar, callose possess high SOD activity, can not only effectively promote human body and remove a variety of reactive oxygens certainly
By the ability of base, and the antioxidant system in human body can also be restored, enhance antioxidant ability of organism；Oleanolic acid triterpene class
Closing object has mitigation hepatic injury, improves the effect of body immunity；
Schisandra chinensis：It astringes the lung, nourshing kidney is promoted the production of body fluid, and sweat, puckery essence are received.
Pueraria lobata：There is expelling pathogenic factors from muscles and skin to bring down a fever, promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie.
Raspberry effect：Supplementing the kidney to control the nocturnal contracting urine, nourishes the liver to improve visual acuity.Antioxidant contained in raspberry can be effectively prevented
Damage of the free radical to brain, and improve the blood and oxygen supply of brain, to have the function that brain tonic and intelligence development；And raspberry
Contained in Flavonoid substances, in addition to have the effects that antibacterial anti-inflammatory, reduce blood pressure and antiallergy other than, they are in skin-protecting face nursing side
Also it displays consummate skill in face.This substance can improve skin blood cycle, and enhancing capillary of skin elasticity promotes Skin Cell again
It is raw, to play the function of beautifying face and moistering lotion；Furthermore contain a kind of ingredient --- anthocyanidin being very useful to health in raspberry
Glycosides, it is with the function for removing free radical, anti-curing cancers generation.
Radix Astragali：Invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic.For treatment deficiency of vital energy weak, rush down prolapse of the anus for a long time, spontaneous perspiration, oedema, sub- official
Prolapsus, chronic rephrilis protinuria, diabetes, the long disunion of the open sore part.
Prepared rehmannia root：For blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, metrostaxis, the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, hectic fever due to yin
Hectic fever, night sweat seminal emission, Heat Diabetes, dizziness, tinnitus, chin hair are early white.
Fructus Forsythiae：Heat-clearing, removing toxic substances, dissipating bind, detumescence.Control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes.
In terms of formula, blood glucose can not only be reduced, and the dry of diabetes can be alleviated in healing process, is urinated more
Symptom makes the excessively upper normal life of patient, and improves the immunity and cell recovery capability of patient.
In order to prove the drug effect of the present invention, verified by following clinical research：
Embodiment 1：Have according to weight composition：Ginseng 20, Inonotus obliquus 60, prepared rehmannia root 39, raspberry 48, pueraria lobata 26, five
Taste 10, Radix Astragali 18, Fructus Forsythiae 21；
Embodiment 2：Have according to weight composition：Ginseng 30, Inonotus obliquus 70, prepared rehmannia root 46, raspberry 56, pueraria lobata 35, five
Taste 16, Radix Astragali 24, Fructus Forsythiae 25；
Embodiment 3：Have according to weight composition：Ginseng 40, Inonotus obliquus 80, prepared rehmannia root 53, raspberry 64, pueraria lobata 44, five
Taste 22, Radix Astragali 30, Fructus Forsythiae 29；
According to following manufacturing method, it is made electuary 1,2,3,4, every packet electuary 20g：
Preparation method includes the following steps：
Step 1 captures medicinal material as requested respectively：The medicinal material of prepared rehmannia root first uses ginger frying before immersion is to boil water, this
Sample prepared rehmannia root will not injure one's stomach.
Inonotus obliquus is made powder, respectively obtains water-soluble extractive and ethanol extract by step 2；
The extracting method of water-soluble extractive is：Be soaked in water Inonotus obliquus powder, and soak at room temperature boils after 24 hours
After 15 minutes, separating filtrate and filter residue；Filtrate is obtained into water-soluble extractive by abstraction technique；
The extracting method of ethanol extract is：The filter residue that will be obtained after boiling is boiled is placed in ethyl alcohol 70 degrees Celsius
Heated at constant temperature 30 minutes, separating filtrate and filter residue；Filtrate is obtained into ethanol extract by abstraction technique.
Ginseng is dried under reduced pressure by step 3 at 60-80 DEG C, and dried object smashes it through 80 mesh sieve, obtains Ginseng Root Powder；
Step 4, by prepared rehmannia root, raspberry, pueraria lobata, Schisandra chinensis, Radix Astragali adds boiling after Fructus Forsythiae is impregnated 48 hours with ethyl alcohol
1 hour is boiled, filter residue and filtrate are detached；
Step 5 adds water-soluble extractive and ethanol extract that step 2 obtains after the cooling of the filtrate of step 3
In the filtrate for entering step 3, stirs 30 minutes, obtain preliminary mixed liquor, then the Ginseng Root Powder that step 2 obtains is added to tentatively
In mixed liquor, a hour is stirred, final Chinese medicine mixed liquor is obtained；
Step 6 is added auxiliary material in final Chinese medicine mixed liquor, stirs evenly, and is granulated, and pack obtains electuary；Auxiliary material by
30g sorbierites, 20g betaine groups at, be first added sorbierite in final Chinese medicine mixed liquor, emulsification floccule is presented in mixed liquor,
Mouthfeel is improved by glycine betaine.
Therapy：It is one group to select 60 patients, 20 people, everyone is one bag sooner or later, after taking four weeks；In vain：Symptom does not have
It is eased, blood glucose does not decline；Effectively：Dry, diuresis remission, blood glucose decline；It cures：Blood glucose is in normal value model
It encloses；As a result it shows：
| Electuary | Patient's number | In vain | Effectively | It cures |
| Electuary 1 | 20 | 0 | 20 | 0 |
| Electuary 2 | 20 | 0 | 15 | 5 |
| Electuary 3 | 20 | 0 | 18 | 2 |
From testing above：Electuary is all effective to diabetes made of formula and method using the present invention, optimal to match
Fang Wei includes according to mass fraction：Ginseng 30, Inonotus obliquus 70, prepared rehmannia root 46, raspberry 56, pueraria lobata 35, Schisandra chinensis 16 are yellow
Stilbene 24, Fructus Forsythiae 25.
After taking four weeks by this 60 patients with electuary again, 56 people fully recover, and blood glucose is discontinued in normal range (NR), spends 2 weeks
Afterwards, effect is checked again for 56 of this recovery from illness, if it is to cure completely to maintain euglycemia, if restoring diabetic symptom again
Then it is judged as not fully recovering, 52 people cure completely in 56 people, and 4 people's blood glucose values increase, but the disease of diabetes do not occur
Shape.It can be seen that taking the electuary of this formula, can heal the sick the Sugar metabolism ability of itself, rather than only control blood glucose.
The present invention provides a kind of preparation method of Chinese medicine preparation and its electuary that treating diabetes B, passes through monarch drug in a prescription ginseng
Blood glucose is reduced with the active ingredient in Inonotus obliquus and restores patient body function, then by the cooperation of ministerial drug, alleviates diabetes
Illness increases the immunity and cell activity of human body so that patient can restore β cell functions.
The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should
Understand, the invention is not limited in any way above-described embodiment, all to be obtained by the way of equivalent substitution or equivalent transformation
Technical solution is all fallen in protection scope of the present invention.
Claims (8)
1. a kind of Chinese medicine preparation for treating diabetes B, which is characterized in that include according to mass fraction：Ginseng 20-40, birch are brown
Pore fungi 60-80.
2. a kind of Chinese medicine preparation for treating diabetes B according to claim 1, which is characterized in that according to mass fraction
Including：Ginseng 20-40, Inonotus obliquus 60-80, prepared rehmannia root 39-53, raspberry 48-64, pueraria lobata 26-44, Schisandra chinensis 10-22 are yellow
Stilbene 18-30, Fructus Forsythiae 21-29.
3. a kind of Chinese medicine preparation for treating diabetes B according to claim 2, which is characterized in that according to mass fraction
Including：Ginseng 30, Inonotus obliquus 70, prepared rehmannia root 46, raspberry 56, pueraria lobata 35, Schisandra chinensis 16, Radix Astragali 24, Fructus Forsythiae 25.
4. a kind of preparation method of instant particles as Chinese medicine that treating diabetes B, which is characterized in that include the following steps：
Step 1 captures following medicinal material according to mass fraction respectively：Ginseng 20-40, Inonotus obliquus 60-80, prepared rehmannia root 39-
53, raspberry 48-64, pueraria lobata 26-44, Schisandra chinensis 10-22, Radix Astragali 18-30, Fructus Forsythiae 21-29；
Inonotus obliquus is made powder, respectively obtains water-soluble extractive and ethanol extract by step 2；
Ginseng is dried under reduced pressure by step 3 at 60-80 DEG C, and dried object smashes it through 80 mesh sieve, obtains Ginseng Root Powder；
Step 4, by prepared rehmannia root, raspberry, pueraria lobata, Schisandra chinensis, Radix Astragali after Fructus Forsythiae is impregnated 48 hours with ethyl alcohol, adds boiling to boil 1
A hour detaches filter residue and filtrate；
Step 5, after the cooling of the filtrate of step 3, step is added in water-soluble extractive and ethanol extract that step 2 is obtained
In rapid three filtrate, stirs 30 minutes, obtain preliminary mixed liquor, then the Ginseng Root Powder that step 2 obtains is added to preliminary mixing
In liquid, a hour is stirred, final Chinese medicine mixed liquor is obtained；
Step 6 is added auxiliary material in final Chinese medicine mixed liquor, stirs evenly, and is granulated, and pack obtains electuary.
5. a kind of preparation method of instant particles as Chinese medicine for treating diabetes B according to claim 4, which is characterized in that water
The extracting method of soluble extract is：Be soaked in water Inonotus obliquus powder, soak at room temperature, after 24 hours, after boiling 15 minutes, point
From filtrate and filter residue；Filtrate is obtained into water-soluble extractive by abstraction technique.
6. a kind of preparation method of instant particles as Chinese medicine for treating diabetes B according to claim 4, which is characterized in that second
The extracting method of alcohol extracting thing is：The filter residue that will be obtained after boiling is boiled is placed on 70 degrees Celsius of heated at constant temperature 30 in ethyl alcohol
Minute, separating filtrate and filter residue；Filtrate is obtained into ethanol extract by abstraction technique.
7. a kind of preparation method of instant particles as Chinese medicine for treating diabetes B according to claim 4, which is characterized in that ripe
The medicinal material of glutinous rehmannia first uses ginger frying before immersion is to boil water.
8. a kind of preparation method of instant particles as Chinese medicine for treating diabetes B according to claim 4, which is characterized in that institute
State auxiliary material includes according to mass percent：58%-65% sorbierites, 35%-42% glycine betaines.
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| CN114177247A (en) * | 2021-12-17 | 2022-03-15 | 广东长昊药业股份有限公司 | Anticancer blood sugar-controlling inonotus obliquus pure powder tablet and preparation method and application thereof |
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Application publication date: 20181012 |