CN1064249C - Traditional Chinese medicine for indication nearsight - Google Patents
Traditional Chinese medicine for indication nearsight Download PDFInfo
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- CN1064249C CN1064249C CN97104314A CN97104314A CN1064249C CN 1064249 C CN1064249 C CN 1064249C CN 97104314 A CN97104314 A CN 97104314A CN 97104314 A CN97104314 A CN 97104314A CN 1064249 C CN1064249 C CN 1064249C
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Abstract
The present invention provides a Chinese medicine preparation for treating myopic eyes, which is mainly composed of pagodatree flower bud. The Chinese medicine preparation is prepared by a method which comprises the following steps that the original medicine of the pagodatree flower bud is taken and put into distilled spirit of 30 to 60 degree and is soaked for 8 to 72 hours at room temperature; the distilled spirit is removed to obtain the soaked original medicine; the original medicine is heated, dried, pulverized and screened to obtain medical powder.
Description
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition of main treatment myopia disease.
Myopia is a kind of commonly encountered diseases and frequently-occurring disease, particularly teenager, because multiple factor is often easily suffered from this disease.In the prior art, the ways and means of treatment and correct myopia eye emerges in an endless stream.The wherein main method that adopts is nothing more than being operation, medicine and various instrument.For example, CN 91197566.6 discloses a kind of preparation method of Chinese medicine for the treatment of pseudomyopia, wherein adopts the Chinese medicine Flos Chrysanthemi, Placenta Hominis, and Rhizoma Chuanxiong, Radix Glycyrrhizae Preparata, Herba Senecionis Scandentis, Semen Cassiae, 10 plurality of Chinese such as Radix Angelicae Sinensis are made a kind of eye drop by certain prescription.In addition, CN 91103283.5 also discloses a kind of medicine pill for the treatment of children's myopia using, and its raw material comprises Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Salviae Miltiorrhizae, 12 flavor Chinese medicines such as the Rhizoma Atractylodis Macrocephalae.There are many unsatisfactory parts in above-mentioned ways and means, and its reason is known.
The method that the object of the present invention is to provide a kind of Chinese medicine preparation of curing nearsight and prepare this Chinese medicine preparation.
In order to finish the present invention's purpose, the following technical scheme of special employing:
The present invention's Chinese medicine preparation can be made up of one or more Chinese medicines of selecting in the following traditional Chinese medicines: Flos Chrysanthemi, Fructus Schisandrae Chinensis, Concha Margaritifera, Semen Cassiae, Nux Prinsepiae, Fructus Lycii, Concha Haliotidis and the Flos Sophorae Immaturus, the dosage of wherein said each Chinese medicine are respectively the 2.5-50 gram.
The present invention's Chinese medicine preparation can be made up of a kind of in Nux Prinsepiae, Concha Haliotidis, Fructus Lycii, the Flos Sophorae Immaturus.
The preparation method of the present invention's Chinese medicine preparation can comprise:
(1). get one or more the former medicine in Flos Chrysanthemi, Fructus Schisandrae Chinensis, Concha Margaritifera, Semen Cassiae, Nux Prinsepiae, Fructus Lycii and the Flos Sophorae Immaturus, put it into respectively in the Chinese liquor of 30-60 degree, soaking at room temperature 8-72 hour, reach sterilization functions simultaneously;
(2). abandon described Chinese liquor, the former medicine after must soaking;
(3). the described former medicine of heating, drying;
(4). pulverize this medicine, sieve, make medicated powder.
When above-mentioned Chinese medicine preparation during by a kind of composition the in Nux Prinsepiae, Concha Haliotidis, Fructus Lycii, the Flos Sophorae Immaturus, described preparation method then is:
(1). get in the Chinese liquor of a kind of 30-60 of the putting it into degree in Nux Prinsepiae, Concha Haliotidis, Fructus Lycii, the Flos Sophorae Immaturus, soaking at room temperature 8-72 hour, reach sterilization functions simultaneously;
(2). abandon described Chinese liquor, the former medicine after must soaking;
(3). the described former medicine of heating, drying;
(4). pulverize this medicine, sieve, make medicated powder.
The above-mentioned medicated powder of making can further be processed into powder or capsule.As powder, whenever capture 5g day and obey secondary, sooner or later respectively take after mixing it with water one bag.
The present invention has following advantage:
1, Chinese medicine preparation of the present invention is treatment adolescent myopia, hypermetropia, amblyopia, scattered-light specific medicament.Take medicine today and take effect tomorrow, long-term efficacy is arranged, treating both the principal and the secondary aspects of a disease at the same time.
2, Chinese medicine preparation of the present invention has nourishing the liver and kidney, beneficial marrow, qi and blood invigorating, blood circulation promoting and blood stasis dispelling, stimulates the menstrual flow, has one's ideas straightened out, makes eye bright, the flat horizontal QI and blood abundance of negative and positive is so disease spontaneous recovery.Think that in theory heat moves back then cloudy giving birth to, cloudyly give birth to that then essence and blood is long, liver opening at eye, the refreshing light in Heisui River belongs to kidney, and the cloudy gas of two livers gains, and then order is bright.
3, prescription essence of the present invention, flavour of a drug are few, no side effects, curative effect is reliable, the cure rate height.
Traditional theory of Chinese medical science is thought, Flos Chrysanthemi, nature and flavor sweetness and bitterness, cold; Record in " pearl sac " " is supported bleeding of eye ", says that it has " making eye bright " in " medication heart method "; Fructus Schisandrae Chinensis nature and flavor acid temperature, nontoxic, say in " Japan hanako materia medica " that it makes eye bright; The Concha Margaritifera nature and flavor are sweet, and cold is nontoxic, liver nourishing the moon, and clearing away liver-fire makes eye bright; The Semen Cassiae nature and flavor are sweet, and cold is nontoxic, and clearing away heat to improve acuity of vision is controlled blindly clearly, and for a long time the clothes benefit is with nothing left; The Nux Prinsepiae nature and flavor are sweet, and are cold, nontoxic, dispel the wind heat radiation, nourishing the liver to improve visual acuity; The Fructus Lycii nature and flavor are sweet flat, nontoxic, nourishing kidney, and tonifying liver makes eye bright; The Concha Haliotidis nature and flavor are salty flat, nontoxic, suppressing the hyperactive liver and subsiding YANG, and heat extraction makes eye bright; The Flos Sophorae Immaturus has the record (Chinese medicine dictionary, Shanghai science tech publishing house, 1986,6 editions) of the retinitis of treatment diabetes in " the northeast medicine is planted will ".
The present invention adopts the concocting method that is different from prior art that above-mentioned Chinese medicine is concocted, and its result shows myopia patient's treatment very effective.
Experimental example 1
The acute toxicity test of Chinese medicine preparation of the present invention is as follows:
One, experiment material
The Chinese medicinal powder that the embodiment of the invention 1 obtains, lot number 921021 (sample that on October 21st, 1 provided) offers the institute for drug control, Heilongjiang Province and experimentizes, and Kunming mouse is provided by this animal housing.
Two, experimental technique
1, medicine is handled: get above-mentioned medicated powder and put porphyrize in the mortar, cross 100 mesh sieves.Be mixed with the suspension of 24% concentration with distilled water, for gastric infusion.Other gets this medicated powder adding distil water and decocted 0.5 hour, and is centrifugal, filters, and precipitate adds water to be handled once by last method again, merges filtrate twice, makes the solution that contains crude drug amount 60% concentration, uses for lumbar injection.
2, be administered orally in the lethal dose that test fails to propose mice.10 of 18-21g mices are got in formal test, and male and female half and half are irritated stomach 0.8ml with the every genus of 24% concentration liquid.Examine the reaction of each Mus after the administration, and write down death toll in 7 days.Each Mus body weight gain after the administration as a result, diet is normal, does not see the overt toxicity reaction, and death does not take place in 10 mices.This moment, the mice dosage was 9.6/kg.
According to People's Republic of China's new drug approval regulation, do the acute toxicity test of multiple dosing in 1 day again.
Other gets 10 of 18-21g mices, male and female half and half.Irritate stomach 0.8ml with the every Mus of 24% concentration liquid at every turn, every 5 hours once, continuous 3 times.Each Mus weight increase after the administration, hair luster, diet, two is just all normal.10 all acomia life and death of mice are died in 7 days.
3, intraperitoneal injection is got 10 of 18-21g mices, male and female half and half.Lumbar injection contains the water extract of crude drug amount 60%, every Mus shot 0.5ml.Observe the toxic reaction of each Mus then, and write down dead mouse number in 7 days.Result mice in back 1 hour of injection flocks together, the movable minimizing.Recover normal later on, do not see the overt toxicity reaction, none generation of mice is dead in 7 days.This moment, the mice dosage was 6g/kg.
Three, brief summary
The dosis tolerata of a gastric infusion of this experiment mice reaches 9.6/kg.And give 3 administrations in the mice 1 day with this dosage, do not see that animal takes place dead yet.This liquid medicine extracting solution reaches 6g/kg to mouse peritoneal injection dosis tolerata.Above-mentioned three experiments there is no tangible toxic reaction and animal dead.Show that this poison of drug property is extremely low.
Experimental example 2
Treat near-sighted clinical observation on the therapeutic effect
Adopt the Chinese medicine of the following embodiment 2 of the present invention to carry out clinical observation 103 examples, its result is as follows for observation analysis:
Clinical money section
Treatment target is that the outpatient service aspiration requires therapist.Inspection item (logarithmic visual acuity chart, subjective optometry, optical fundus etc.) and 103 more complete examples of registration card that statistics carries out for regulation, 197 eyes, wherein male 47 examples, 89 eyes, women 56 examples, 108 eyes.The myopia vision sees Table one, and its myopic degree sees Table two, and age distribution sees Table three.Curative effect determinate standard sees Table four.
The near-sighted information slip of table one
| Vision | The eye number | ％ | Vision | The eye number | ％ |
| ≤4.0 | 14 | 7.1 | 4.5 | 33 | 16.7 |
| 4.1 | 6 | 3.0 | 4.6 | 19 | 9.6 |
| 4.2 | 20 | 10.0 | 4.7 | 28 | 14.2 |
| 4.3 | 21 | 10.6 | 4.8 | 18 | 9.1 |
| 4.4 | 31 | 15.7 | 4.9 | 7 | 3.5 |
The bathomorphic ametropia table of degree of table two
| Myopic degree | Slightly | Moderate | Highly | Add up to |
| Eye number (only) | 52 | 83 | 62 | 197 |
| ％ | 26 | 43 | 31 | 100％ |
The near-sighted age distribution table of table three
| Age (year) | ≤10 | ～12 | ～14 | ～16 | ～18 | ～20 | ＞20 |
| The eye number | 40 | 48 | 42 | 22 | 10 | 14 | |
| 20.30 | 10.65 | 24.36 | 21.31 | 11.16 | 5.0＞ | 7.1 |
Therapeutic Method
1, be defined as on inspection ametropic in conjunction with throw giving powder of the present invention after optical fundus and the optometry 5.0g/ time one day twice, warm water delivery service, 10 days is a course of treatment.
2, points for attention: prohibit during the treatment and see TV, video and Play Station games, novel.
Observation of curative effect
Curative effect determinate standard:
Table four curative effect determinate standard
| Curative effect | Treatment back vision improves line number | The eye number | ％ |
| Effectively | 〉=2 row | 185 | 93.90 |
| Produce effects | 3-5 capable (being lower than 4.9) | 41 | 20.81 |
| Basic cure rate | 〉=3 row (reaching 5.0) | 114 | 57.87 |
| Cure | 〉=6 row (being higher than 5.0) | 30 | 15.22 |
| Invalid | ＜2 row (no change) | 12 | 6.0 |
Annotate: calculate with logarithmic visual acuity chart nature line number.
Brief summary
1, motherland's medical science thinks that teenager is the vigorous time of growth of " long QI and blood, spermatogenesis god, Fructus Alpiniae Oxyphyllae are intelligent ", to being in great demand of QI and blood, also belongs to the body of " the young sun of young the moon ", the deficient eyes of QI and blood easily takes place lose and support and cause myopia.Medicine confirms that through clinical observation clinical effective rate is 93.90% promptly at this etiopathogenesis among the present invention, and basic cure rate is 57.87% (reaching 5.0), obvious effective rate 20.81%, cure rate 15.22% (being higher than 5.0), and inefficiency 6.0%.Total cure rate reaches 73.2%.
2, this group case combines in 10～18 years old juvenile group of person more, and adult group is less, and other oculopathy is not related to.
3,103 examples of Guan Chaing are taken medicine the stage trimestral, and are the shortest in a course of treatment, and the longest eight courses of treatment, most continuous was taken medicine 30～50 days.
4, the strict vision check of grasping after taking medicine, minimum more than 2 times, special case is up to 9 times more than.
Experimental example 3
Indivedual medical records: Zhai * *, the woman, 12 years old, be Harbin power-section Wang Zhao primary school student, clinical diagnosis is an amblyopia, naked vision 0.3, after the Chinese medicine preparation that adopts the following embodiment 3 of the present invention to make was treated in 25 days, eyes reached 1.2 respectively.
Experimental example 4
Indivedual medical records: the week * *, the woman 15 years old, is Harbin railway one middle school student.Clinical diagnosis is myopia 350 degree, astigmatism 150, and eyes are naked to be considered as 0.2, the preparation for treating through adopting following embodiment 1 45 days, its eyes reach 1.2 respectively.
Experimental example 5
Indivedual medical records: horse *, man, 14 years old, Heilongjiang Province's Heihe City two middle school student.Clinical diagnosis is a hypermetropia, and naked vision is 0.3, the preparation for treating through adopting the following embodiment 4 of the present invention 30 days, and its binocular vision reaches 1.0.
Embodiment 1
Get the former medicine of Flos Chrysanthemi, Fructus Schisandrae Chinensis, Concha Margaritifera, Semen Cassiae, Nux Prinsepiae, Fructus Lycii, Concha Haliotidis and the Flos Sophorae Immaturus, Nux Prinsepiae will be removed the peel shell, deoils with grease press, in the Chinese liquor that puts it into 30 degree respectively, former medicine is crossed in the Chinese liquor desert, and soaking at room temperature reaches sterilization functions more than 8 hours simultaneously.Discard described Chinese liquor then, the above-mentioned former medicine after obtaining soaking.With the described former medicine of medicine roasting machine heating, drying.Dosage by the above-mentioned Chinese medicine of every flavor is that 2.5 prescriptions that restrain are deployed into a medicinal mixture, pulverizes this medicinal mixture with cracker for medicine, crosses 60 mesh sieves, makes a medicated powder.
The medicated powder that obtains can pack through aluminum is thin with racking machine, be made every bag 5 product that restrains.
Embodiment 2
Get the former medicine of Flos Chrysanthemi, Fructus Schisandrae Chinensis, Concha Margaritifera, Semen Cassiae, Nux Prinsepiae, Fructus Lycii, Concha Haliotidis and the Flos Sophorae Immaturus, Nux Prinsepiae will be removed the peel shell, deoils with grease press, in the Chinese liquor that puts it into 60 degree respectively, former medicine is crossed in the Chinese liquor desert, and soaking at room temperature 72 hours reaches sterilization functions simultaneously.Discard described Chinese liquor then, the above-mentioned former medicine after obtaining soaking.With the described former medicine of medicine roasting machine heating, drying.Dosage by the above-mentioned Chinese medicine of every flavor is that 50 prescriptions that restrain are deployed into a medicinal mixture, pulverizes this medicinal mixture with cracker for medicine, crosses 60 mesh sieves, makes a medicated powder.
The medicated powder that obtains adopts known method that it is incapsulated, and makes oral capsule.
Embodiment 3
Get the former medicine of Fructus Lycii, Concha Haliotidis and the Flos Sophorae Immaturus, Nux Prinsepiae will be removed the peel shell, deoils with grease press, and in the Chinese liquor that puts it into 56 degree respectively, former medicine is crossed in the Chinese liquor desert, and soaking at room temperature 24 hours reaches sterilization functions simultaneously.Discard described Chinese liquor then, the above-mentioned former medicine after obtaining soaking.With the described former medicine of medicine roasting machine heating, drying.Dosage by the above-mentioned Chinese medicine of every flavor is that 50 prescriptions that restrain are deployed into a medicinal mixture, pulverizes this medicinal mixture with cracker for medicine, crosses 60 mesh sieves, makes a medicated powder.
Embodiment 4
Flos Chrysanthemi is put into 35 Chinese liquor of spending, and former medicine is crossed in the Chinese liquor desert, and soaking at room temperature 24 hours reaches sterilization functions simultaneously.Discard described Chinese liquor then, the above-mentioned former medicine after obtaining soaking.With the described former medicine of medicine roasting machine heating, drying.Pulverize this medicinal mixture with cracker for medicine, cross 40 mesh sieves, make a medicated powder.
Claims (1)
1, the bathomorphic Chinese medicine preparation of a kind of treatment, it is characterized in that: described Chinese medicine preparation mainly is made up of the Flos Sophorae Immaturus, and it is to prepare by the preparation method that comprises the steps:
(1) gets the former medicine of the Flos Sophorae Immaturus, put it in the Chinese liquor of 30-60 degree soaking at room temperature 8-72 hour;
(2) abandon described Chinese liquor, the former medicine after must soaking;
(3) the former medicine after heating, drying should soak;
(4) pulverize the former medicine of this oven dry, sieve, make medicated powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97104314A CN1064249C (en) | 1997-05-28 | 1997-05-28 | Traditional Chinese medicine for indication nearsight |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97104314A CN1064249C (en) | 1997-05-28 | 1997-05-28 | Traditional Chinese medicine for indication nearsight |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94104076A Division CN1043846C (en) | 1994-04-14 | 1994-04-14 | Traditional Chinese medicine preparation for mainly curing myopia |
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| Publication Number | Publication Date |
|---|---|
| CN1174718A CN1174718A (en) | 1998-03-04 |
| CN1064249C true CN1064249C (en) | 2001-04-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN97104314A Expired - Fee Related CN1064249C (en) | 1997-05-28 | 1997-05-28 | Traditional Chinese medicine for indication nearsight |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105166229A (en) * | 2015-09-11 | 2015-12-23 | 上海婉静纺织科技有限公司 | Myopia preventing health-care tea |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1039726A (en) * | 1989-09-04 | 1990-02-21 | 罗勇 | Chinese medicine make eye bright crystal formulations and production method thereof |
| CN1071337A (en) * | 1992-08-05 | 1993-04-28 | 马兴源 | The preparation method of oral liquid improving visual acuity and refreshing brain |
| CN1086434A (en) * | 1993-01-13 | 1994-05-11 | 王凯 | Jinshiling |
| CN1104516A (en) * | 1993-12-31 | 1995-07-05 | 张后伟 | Chinese medicine for myopia |
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- 1997-05-28 CN CN97104314A patent/CN1064249C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1039726A (en) * | 1989-09-04 | 1990-02-21 | 罗勇 | Chinese medicine make eye bright crystal formulations and production method thereof |
| CN1071337A (en) * | 1992-08-05 | 1993-04-28 | 马兴源 | The preparation method of oral liquid improving visual acuity and refreshing brain |
| CN1086434A (en) * | 1993-01-13 | 1994-05-11 | 王凯 | Jinshiling |
| CN1104516A (en) * | 1993-12-31 | 1995-07-05 | 张后伟 | Chinese medicine for myopia |
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| Publication number | Publication date |
|---|---|
| CN1174718A (en) | 1998-03-04 |
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