CN107073138B - 降低由pd-l1诱导的免疫耐受性 - Google Patents
降低由pd-l1诱导的免疫耐受性 Download PDFInfo
- Publication number
- CN107073138B CN107073138B CN201680002926.1A CN201680002926A CN107073138B CN 107073138 B CN107073138 B CN 107073138B CN 201680002926 A CN201680002926 A CN 201680002926A CN 107073138 B CN107073138 B CN 107073138B
- Authority
- CN
- China
- Prior art keywords
- cells
- cell
- modified
- car
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Transplantation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810281004.XA CN108410892B (zh) | 2015-03-02 | 2016-03-01 | 降低由pd-l1诱导的免疫耐受性 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562126804P | 2015-03-02 | 2015-03-02 | |
| US62/126,804 | 2015-03-02 | ||
| PCT/CN2016/075061 WO2016138846A1 (en) | 2015-03-02 | 2016-03-01 | Reducing immune tolerance induced by pd‐l1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810281004.XA Division CN108410892B (zh) | 2015-03-02 | 2016-03-01 | 降低由pd-l1诱导的免疫耐受性 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107073138A CN107073138A (zh) | 2017-08-18 |
| CN107073138B true CN107073138B (zh) | 2018-06-29 |
Family
ID=56848306
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680002926.1A Active CN107073138B (zh) | 2015-03-02 | 2016-03-01 | 降低由pd-l1诱导的免疫耐受性 |
| CN201810281004.XA Active CN108410892B (zh) | 2015-03-02 | 2016-03-01 | 降低由pd-l1诱导的免疫耐受性 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810281004.XA Active CN108410892B (zh) | 2015-03-02 | 2016-03-01 | 降低由pd-l1诱导的免疫耐受性 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US9572837B2 (enExample) |
| EP (2) | EP3089761B1 (enExample) |
| JP (2) | JP6336684B2 (enExample) |
| KR (1) | KR102133857B1 (enExample) |
| CN (2) | CN107073138B (enExample) |
| AU (1) | AU2016228080B2 (enExample) |
| BR (1) | BR112017018770A2 (enExample) |
| CA (1) | CA2976684C (enExample) |
| RU (1) | RU2688692C2 (enExample) |
| SG (1) | SG11201706947TA (enExample) |
| WO (1) | WO2016138846A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| PL3253865T3 (pl) | 2015-02-06 | 2022-10-10 | National University Of Singapore | Sposoby wzmacniania skuteczności terapeutycznych komórek odpornościowych |
| EP3089761B1 (en) * | 2015-03-02 | 2019-06-12 | Innovative Cellular Therapeutics Co., Ltd. | Reducing immune tolerance induced by pd l1 |
| DK3298033T4 (da) | 2015-05-18 | 2023-10-02 | Tcr2 Therapeutics Inc | Sammensætninger og medicinske anvendelser til tcr-reprogrammering under anvendelse af fusionsproteiner |
| HK1258041A1 (zh) | 2015-09-04 | 2019-11-01 | 纪念斯隆-凯特林癌症中心 | 免疫细胞组合物和使用方法 |
| CN109072194B (zh) | 2015-12-09 | 2022-12-27 | 纪念斯隆-凯特林癌症中心 | 免疫细胞组合物及其使用方法 |
| EP4286522A3 (en) * | 2016-03-23 | 2024-02-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
| EP3988111A1 (en) | 2016-04-01 | 2022-04-27 | Innovative Cellular Therapeutics Holdings, Ltd. | Use of chimeric antigen receptor modified cells to treat cancer |
| US10654934B2 (en) | 2016-04-01 | 2020-05-19 | Innovative Cellular Therapeutics CO., LTD. | Use of chimeric antigen receptor modified cells to treat cancer |
| CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| JP7109789B2 (ja) | 2016-08-02 | 2022-08-01 | ティーシーアール2 セラピューティクス インク. | 融合タンパク質を使用したtcrの再プログラム化のための組成物及び方法 |
| EP3507361A1 (en) | 2016-08-30 | 2019-07-10 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use for treating viral and other infections |
| WO2018064921A1 (en) * | 2016-10-06 | 2018-04-12 | Innovative Cellular Therapeutics CO., LTD. | Use of chimeric antigen receptor modified cells to treat cancer |
| CA3036745A1 (en) | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| JP7778468B2 (ja) | 2016-11-22 | 2025-12-02 | ナショナル ユニバーシティ オブ シンガポール | T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 |
| CN108148862B (zh) * | 2016-12-05 | 2019-03-08 | 上海优卡迪生物医药科技有限公司 | 一种封闭pdl1的用于抑制免疫逃脱的car-t转基因载体及其构建方法和应用 |
| US20190358263A1 (en) | 2016-12-07 | 2019-11-28 | Oslo Universitetssykehus Hf | Compositions and Methods for Cell Therapy |
| US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| US11850262B2 (en) | 2017-02-28 | 2023-12-26 | Purdue Research Foundation | Compositions and methods for CAR T cell therapy |
| EP3592368A1 (en) * | 2017-03-08 | 2020-01-15 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use |
| CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
| SG11202000402PA (en) | 2017-08-10 | 2020-02-27 | Nat Univ Singapore | T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof |
| WO2019067504A1 (en) * | 2017-09-26 | 2019-04-04 | Longwood University | SPECIFIC CHIMERIC ANTIGEN RECEPTOR AT PD-1 AS IMMUNOTHERAPY |
| CN109836493A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种靶向cd19的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| US10561686B2 (en) * | 2018-01-12 | 2020-02-18 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| CN120154716A (zh) | 2018-01-22 | 2025-06-17 | 恩多塞特公司 | Car t细胞的使用方法 |
| JP7774961B2 (ja) | 2018-02-06 | 2025-11-25 | シアトル チルドレンズ ホスピタル ディー/ビー/エイ シアトル チルドレンズ リサーチ インスティテュート | フルオレセイン結合エーテルリン脂質(fl-ple)で標識された腫瘍に対して最適なt細胞機能を示すフルオレセイン特異的car |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| CA3091674A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| AU2019275076B2 (en) | 2018-05-23 | 2024-12-19 | National University Of Singapore | Blockade of CD2 surface expression and expression of chimeric antigen receptors for immunotherapy of T-cell malignancies |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| EP3870146A4 (en) * | 2018-10-25 | 2022-08-10 | Innovative Cellular Therapeutics Holdings, Ltd. | Increase or maintaining t-cell subpopulations in adoptive t-cell therapy |
| US10918667B2 (en) | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
| WO2020116686A1 (ko) | 2018-12-06 | 2020-06-11 | 고려대학교 산학협력단 | 인간 항-antxr 키메라 항원 수용체 및 이의 용도 |
| CN109971842A (zh) * | 2019-02-15 | 2019-07-05 | 成都美杰赛尔生物科技有限公司 | 一种检测CRISPR-Cas9脱靶效应的方法 |
| WO2020172555A1 (en) * | 2019-02-21 | 2020-08-27 | Regents Of The University Of Minnesota | Genetically modified gamma delta t cells and methods of making and using |
| AU2020232216B2 (en) * | 2019-03-01 | 2025-09-25 | Allogene Therapeutics, Inc. | Chimeric cytokine receptors bearing a PD-1 ectodomain |
| JP2022531814A (ja) * | 2019-03-12 | 2022-07-12 | イノベイティブ セルラー セラピューティクス ホールディングス,エルティディ | 改変細胞の増幅およびその応用 |
| US11739136B2 (en) * | 2019-03-18 | 2023-08-29 | Innovative Cellular Therapeutics Holdings, Ltd. | Inducible dominant negative PD-1 and uses in adoptive cell therapy |
| CN109868263A (zh) * | 2019-03-29 | 2019-06-11 | 深圳精准医疗科技有限公司 | 重组单纯疱疹病毒及其制备方法和应用、重组载体的构建方法及其应用 |
| AU2020276117A1 (en) * | 2019-05-16 | 2021-12-09 | Memorial Sloan-Kettering Cancer Center | Mesothelin cars and uses thereof |
| CN110423767A (zh) * | 2019-07-12 | 2019-11-08 | 华东师范大学 | 表达可溶性pd-1的嵌合抗原受体car基因及应用 |
| CN110592140A (zh) * | 2019-09-30 | 2019-12-20 | 王清路 | Pd-1基因缺陷型pd-1-cart细胞制剂的制法 |
| US20210137983A1 (en) * | 2019-11-08 | 2021-05-13 | Innovative Cellular Therapeutics Holdings, Ltd. | Nk cell expansion and uses thereof |
| KR102674654B1 (ko) | 2019-11-26 | 2024-06-12 | 난트퀘스트, 인크. | 일차 nk car 구축물 및 방법 |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
| US12043654B2 (en) | 2020-06-02 | 2024-07-23 | Innovative Cellular Therapeutics Holdings, Ltd. | Anti-GCC antibody and CAR thereof for treating digestive system cancer |
| JP7198302B2 (ja) * | 2021-03-08 | 2022-12-28 | 一般財団法人 化学物質評価研究機構 | Pd-1を介した免疫チェックポイント阻害剤の生物活性試験法 |
| US20230227779A1 (en) | 2022-01-19 | 2023-07-20 | Innovative Cellular Therapeutics Holdings, Ltd. | Enhanced Chimeric Antigen Receptor Cells in Hypoxic Tumor Microenvironment |
| WO2025184170A1 (en) * | 2024-02-27 | 2025-09-04 | Overt Bio, Inc. | Methods and compositions for improving t cell function in an immunosuppressive environment |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013019615A2 (en) * | 2011-07-29 | 2013-02-07 | The Trustees Of The University Of Pennsylvania | Switch costimulatory receptors |
| CN103492406A (zh) * | 2010-12-09 | 2014-01-01 | 宾夕法尼亚大学董事会 | 嵌合抗原受体-修饰的t细胞治疗癌症的用途 |
| WO2014059173A2 (en) * | 2012-10-10 | 2014-04-17 | Sangamo Biosciences, Inc. | T cell modifying compounds and uses thereof |
| WO2014145252A2 (en) * | 2013-03-15 | 2014-09-18 | Milone Michael C | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| CN104718284A (zh) * | 2012-05-25 | 2015-06-17 | 塞勒克提斯公司 | 工程化用于免疫疗法的异体和免疫抑制耐受性t细胞的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| WO2003022875A2 (en) * | 2001-09-07 | 2003-03-20 | Everygene Ab | Polymorphisms of pd-1 |
| KR101471647B1 (ko) * | 2011-10-26 | 2014-12-11 | 국립암센터 | 변이 ctla4 유전자 이입 t 세포 및 이를 포함하는 항암 면역치료용 조성물 |
| EP2814846B1 (en) * | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| AU2013204922B2 (en) * | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| KR102363191B1 (ko) * | 2013-02-26 | 2022-02-17 | 메모리얼 슬로안 케터링 캔서 센터 | 면역치료용 조성물 및 방법 |
| CN105431449B (zh) | 2013-04-05 | 2021-08-24 | 港大科桥有限公司 | 新的pd1同种型及其用于加强免疫应答的用途 |
| KR102164455B1 (ko) | 2013-05-08 | 2020-10-13 | 삼성전자주식회사 | 콘텐트 제공 방법, 콘텐트 제공 장치 및 그 콘텐트 제공 시스템 |
| JP6603209B2 (ja) * | 2013-05-10 | 2019-11-06 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | ソルターゼ(Sortase)を用いた生存細胞のタンパク質修飾 |
| EP3811970A1 (en) | 2014-03-15 | 2021-04-28 | Novartis AG | Regulatable chimeric antigen receptor |
| EP3593812A3 (en) | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| ES2819451T3 (es) * | 2014-08-08 | 2021-04-16 | Univ Leland Stanford Junior | Agentes PD-1 de alta afinidad y procedimientos de uso |
| EP3089761B1 (en) | 2015-03-02 | 2019-06-12 | Innovative Cellular Therapeutics Co., Ltd. | Reducing immune tolerance induced by pd l1 |
| US10493139B2 (en) | 2015-07-24 | 2019-12-03 | Innovative Cellular Therapeutics CO., LTD. | Humanized anti-CD19 antibody and use thereof with chimeric antigen receptor |
| HK1258041A1 (zh) | 2015-09-04 | 2019-11-01 | 纪念斯隆-凯特林癌症中心 | 免疫细胞组合物和使用方法 |
| EP3362074B1 (en) | 2015-10-16 | 2023-08-09 | President and Fellows of Harvard College | Regulatory t cell pd-1 modulation for regulating t cell effector immune responses |
| CN109072194B (zh) | 2015-12-09 | 2022-12-27 | 纪念斯隆-凯特林癌症中心 | 免疫细胞组合物及其使用方法 |
| CN112088008B (zh) | 2018-01-11 | 2024-01-02 | 浙江煦顼技术有限公司 | 修饰细胞的扩增及其用途 |
| EP3870146A4 (en) | 2018-10-25 | 2022-08-10 | Innovative Cellular Therapeutics Holdings, Ltd. | Increase or maintaining t-cell subpopulations in adoptive t-cell therapy |
-
2016
- 2016-03-01 EP EP16717825.0A patent/EP3089761B1/en active Active
- 2016-03-01 JP JP2017546893A patent/JP6336684B2/ja active Active
- 2016-03-01 RU RU2017130985A patent/RU2688692C2/ru active
- 2016-03-01 EP EP19172425.1A patent/EP3549612B1/en active Active
- 2016-03-01 WO PCT/CN2016/075061 patent/WO2016138846A1/en not_active Ceased
- 2016-03-01 CA CA2976684A patent/CA2976684C/en active Active
- 2016-03-01 AU AU2016228080A patent/AU2016228080B2/en not_active Ceased
- 2016-03-01 CN CN201680002926.1A patent/CN107073138B/zh active Active
- 2016-03-01 CN CN201810281004.XA patent/CN108410892B/zh active Active
- 2016-03-01 KR KR1020177027722A patent/KR102133857B1/ko active Active
- 2016-03-01 BR BR112017018770-1A patent/BR112017018770A2/pt not_active Application Discontinuation
- 2016-03-01 SG SG11201706947TA patent/SG11201706947TA/en unknown
- 2016-04-07 US US15/093,643 patent/US9572837B2/en active Active
- 2016-12-08 US US15/373,012 patent/US10619136B2/en active Active
-
2017
- 2017-11-21 JP JP2017223489A patent/JP6767347B2/ja active Active
-
2019
- 2019-05-06 US US16/404,349 patent/US10865382B2/en active Active
-
2020
- 2020-11-23 US US17/101,780 patent/US11932873B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103492406A (zh) * | 2010-12-09 | 2014-01-01 | 宾夕法尼亚大学董事会 | 嵌合抗原受体-修饰的t细胞治疗癌症的用途 |
| WO2013019615A2 (en) * | 2011-07-29 | 2013-02-07 | The Trustees Of The University Of Pennsylvania | Switch costimulatory receptors |
| CN104718284A (zh) * | 2012-05-25 | 2015-06-17 | 塞勒克提斯公司 | 工程化用于免疫疗法的异体和免疫抑制耐受性t细胞的方法 |
| WO2014059173A2 (en) * | 2012-10-10 | 2014-04-17 | Sangamo Biosciences, Inc. | T cell modifying compounds and uses thereof |
| WO2014145252A2 (en) * | 2013-03-15 | 2014-09-18 | Milone Michael C | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
Non-Patent Citations (3)
| Title |
|---|
| Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo;Michael C. Milone,等;《Molecular Therapy》;20090421;第17卷(第8期);参见第1453-1464页 * |
| PD-1– and CTLA-4–based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses;Victor D. Fedorov,等;《Sci Transl Med.》;20131211;第5卷(第215期);第1-25页 * |
| sPD-1封闭PD-L促进抗瘤免疫的机制研究;贺兰湘,等;《中华微生物学和免疫学杂志》;20060531;第26卷(第5期);第463-467页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201706947TA (en) | 2017-09-28 |
| RU2017130985A3 (enExample) | 2019-03-04 |
| CN108410892B (zh) | 2021-05-28 |
| CA2976684C (en) | 2024-03-05 |
| US10619136B2 (en) | 2020-04-14 |
| US20210079349A1 (en) | 2021-03-18 |
| BR112017018770A2 (pt) | 2018-04-17 |
| US20160256488A1 (en) | 2016-09-08 |
| US9572837B2 (en) | 2017-02-21 |
| US11932873B2 (en) | 2024-03-19 |
| JP2018064568A (ja) | 2018-04-26 |
| CN107073138A (zh) | 2017-08-18 |
| EP3549612B1 (en) | 2025-04-30 |
| JP2018508539A (ja) | 2018-03-29 |
| RU2017130985A (ru) | 2019-03-04 |
| KR102133857B1 (ko) | 2020-07-20 |
| AU2016228080B2 (en) | 2020-11-12 |
| US20170096638A1 (en) | 2017-04-06 |
| EP3089761A1 (en) | 2016-11-09 |
| US10865382B2 (en) | 2020-12-15 |
| RU2688692C2 (ru) | 2019-05-22 |
| EP3089761A4 (en) | 2017-05-10 |
| CA2976684A1 (en) | 2016-09-09 |
| WO2016138846A1 (en) | 2016-09-09 |
| US20190316086A1 (en) | 2019-10-17 |
| AU2016228080A1 (en) | 2017-09-07 |
| EP3549612A1 (en) | 2019-10-09 |
| JP6336684B2 (ja) | 2018-06-06 |
| KR20170124576A (ko) | 2017-11-10 |
| CN108410892A (zh) | 2018-08-17 |
| EP3089761B1 (en) | 2019-06-12 |
| JP6767347B2 (ja) | 2020-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11932873B2 (en) | Reducing immune tolerance induced by PD-L1 | |
| US20240218075A1 (en) | Use of chimeric antigen receptor modified cells to treat cancer | |
| US20180223255A1 (en) | Activation and Expansion of T Cells | |
| US11773384B2 (en) | Chimeric antigen receptor (CAR) and T cell receptor (TCR) modified T cells | |
| CN110257338B (zh) | 嵌合细胞因子受体 | |
| WO2018064921A1 (en) | Use of chimeric antigen receptor modified cells to treat cancer | |
| CN110540997B (zh) | 靶向bcma嵌合抗原受体、核酸序列、载体及应用 | |
| HK1228783A1 (en) | Reducing immune tolerance induced by pd l1 | |
| HK1228783B (en) | Reducing immune tolerance induced by pd l1 | |
| HK40073625A (en) | Use of chimeric antigen receptor modified cells to treat cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211130 Address after: 201203 floor 3, building 1, No. 6055, Jinhai Road, Fengxian District, Shanghai Patentee after: Shanghai Xuxu Technology Co.,Ltd. Address before: 201203 Room 201, building 4, 998 HaLei Road, Pudong New Area, Shanghai Patentee before: SHANGHAI SIDANSAI BIOTECHNOLOGY CO.,LTD. |
|
| TR01 | Transfer of patent right | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: No. 29, 1st Floor, Building 2, No. 198 Peninsula Middle Road, Dipu Street, Anji County, Huzhou City, Zhejiang Province, 313300 (self declared) Patentee after: Zhejiang Xuxu Technology Co.,Ltd. Address before: 201203 floor 3, building 1, No. 6055, Jinhai Road, Fengxian District, Shanghai Patentee before: Shanghai Xuxu Technology Co.,Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Reduce immune tolerance induced by PD-L1 Effective date of registration: 20231124 Granted publication date: 20180629 Pledgee: Industrial Bank Co.,Ltd. Shanghai Branch Pledgor: Zhejiang Xuxu Technology Co.,Ltd. Registration number: Y2023310000772 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20180629 Pledgee: Industrial Bank Co.,Ltd. Shanghai Branch Pledgor: Zhejiang Xuxu Technology Co.,Ltd. Registration number: Y2023310000772 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Reduce immune tolerance induced by PD-L1 Granted publication date: 20180629 Pledgee: Industrial Bank Co.,Ltd. Shanghai Hongqiao Branch Pledgor: Zhejiang Xuxu Technology Co.,Ltd. Registration number: Y2024310001284 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20180629 Pledgee: Industrial Bank Co.,Ltd. Shanghai Hongqiao Branch Pledgor: Zhejiang Xuxu Technology Co.,Ltd. Registration number: Y2024310001284 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |