CN107073138B - 降低由pd-l1诱导的免疫耐受性 - Google Patents
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Abstract
Description
SEQ ID NO:# | 标识符 |
SEQ ID NO:1 | P0(核酸序列) |
SEQ ID NO:2 | P1(核酸序列) |
SEQ ID NO:3 | P2(核酸序列) |
SEQ ID NO:4 | P3(核酸序列) |
SEQ ID NO:5 | P4(核酸序列) |
SEQ ID NO:6 | IRES元件(核酸序列) |
SEQ ID NO:7 | PDL1-IRES-EGFP(核酸序列) |
SEQ ID NO:8 | PD-1信号肽(氨基酸序列) |
SEQ ID NO:9 | PD-1胞外结构域(氨基酸序列) |
SEQ ID NO:10 | PD-1跨膜结构域(氨基酸序列) |
SEQ ID NO:11 | P1:添加的亲水性链段 |
SEQ ID NO:12 | P2:PD-1胞内结构域残基(氨基酸序列) |
SEQ ID NO:13 | P3:PD-1胞内结构域残基(氨基酸序列) |
SEQ ID NO:14 | P4:PD-1胞内结构域残基(氨基酸序列) |
SEQ ID NO:15 | P2:PD-1胞内结构域的移除部分(氨基酸序列) |
SEQ ID NO:16 | P4:PD-1胞内结构域的移除部分(氨基酸序列) |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810281004.XA CN108410892B (zh) | 2015-03-02 | 2016-03-01 | 降低由pd-l1诱导的免疫耐受性 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562126804P | 2015-03-02 | 2015-03-02 | |
US62/126,804 | 2015-03-02 | ||
PCT/CN2016/075061 WO2016138846A1 (en) | 2015-03-02 | 2016-03-01 | Reducing immune tolerance induced by pd‐l1 |
Related Child Applications (1)
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CN201810281004.XA Division CN108410892B (zh) | 2015-03-02 | 2016-03-01 | 降低由pd-l1诱导的免疫耐受性 |
Publications (2)
Publication Number | Publication Date |
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CN107073138A CN107073138A (zh) | 2017-08-18 |
CN107073138B true CN107073138B (zh) | 2018-06-29 |
Family
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BR112017018770A2 (pt) | 2018-04-17 |
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RU2017130985A3 (zh) | 2019-03-04 |
US20160256488A1 (en) | 2016-09-08 |
JP6767347B2 (ja) | 2020-10-14 |
CN108410892A (zh) | 2018-08-17 |
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