CN107048408A - Prepare improves cancer patient illness, the fermentation composition of the plant enzyme of raising life quality effect and preparation method with conditioning - Google Patents
Prepare improves cancer patient illness, the fermentation composition of the plant enzyme of raising life quality effect and preparation method with conditioning Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention provides a kind of fermentation composition prepared with conditioning improvement cancer patient illness, the plant enzyme for improving life quality effect, is made up of yeast beta glucan, functional oligose, probiotics and integration of drinking and medicinal herbs food materials；Integration of drinking and medicinal herbs food materials is mainly prepared from by the raw material of following parts by weight：10~45 parts of acerola concentrate powder and 8~30 parts of Antrodia camphorata；Additionally provide the plant enzyme of fermentation composition preparation method and its preparation.The fermentation composition is novel fermentation product, is that the bacterium bag is easy to use for preparing ferment " fermentation bacterium bag ", the industrialized production of suitable all kinds of plant enzymes.
Description
Technical field
The invention belongs to prevent conditioning maintenance product field, more particularly to prepared by one kind to improve cancer patient disease with conditioning
Disease, the fermentation composition and preparation method for improving life quality effect.
Background technology
Plant enzyme is always the best seller of ferment class product.Plant enzyme is by tens of kinds of different vegetables and fruits, cereal, seas
The plant such as algae and mushroom class, develops through spontaneous fermentation, remains the nutrition elite in plant, contains the various of human body needs
Ferment, oligosaccharides and a variety of vitamins and mineral matter, can produce abundant SOD antioxidase compositions again, improve anti-oxidant energy in vivo
Power, and then strengthen immunity.
Existing traditional handicraft and modern crafts to ferment has all done further improvement, while also occurring in that some addition benefits
Health food prepared by the ferment and ferment of raw bacterium.Probiotics fermention fruits and vegetables, can activate the effective efficiency composition in fruits and vegetables, molten
Go out active effect material of more elite.But, traditional ferment technique can not be used flexibly on a large scale, or without effect fermentation
Composition can flexibly be used in the industrial manufacturing processes of different ferment；Promoting metabolism in vivo in order to improve ferment, adjusting
The effect in terms of functions of intestines and stomach is managed, and adapts to use on a large scale, applicant further changes to the fermentate for preparing ferment
It is good, and develop the formula for the function affect for improving ferment.
There is physiologically active, not by human body hydrochloric acid in gastric juice, gastric enzyme degraded in addition, functional oligose is a class, do not inhaled in small intestine
Receive, reach the oligosaccharide of big intestines；Oligosaccharide is prebiotics, is the substrate of the growth of probiotics, and with promoting, human body is prebiotic
The physiological functions such as the propagation of bacterium.By the way that probiotics and functional oligose are used in conjunction with, between the two with synergy, energy
Promote the regulatory function to gut flora.Co between probiotics and oligosaccharide, be probiotic in symphysis unit and
Co between prebiotics, they complement each other, and play a role jointly, promote beneficial bacterium growing multiplication, suppress harmful bacteria
Growth；Research shows that both uses can increase the quantity of Bifidobacterium in healthy human faecal mass, but individually take probiotics and have no
This effect.Such as the enzyme composition that patent CN106174179A is related to, probiotics and functional oligose are used in combination, and
Traditional Chinese medicine ingredients are added, its given efficacy is reached.But its preparation being formulated is applied to individual and directly taken, and fixed plant enzyme
Stoste can not meet different taste Man's Demands when reusing, and its preparation method is coarse, in the ferment effervescent tablet being prepared into
The sense of the medicine dregs of a decoction is strong, and mouthfeel is not good.
On the other hand, existing ferment bucket, prepares plant enzyme so that plant enzyme using fruit, sugar and water as raw material
It can be prepared in family, it is easy to operate.But also having many weak points, the time prepared by 1. ferment is still longer, Er Qierong
Easily prepare failure；2. made from plant enzyme effect it is indefinite, user can not oneself control prepare effect of plant enzyme, than
Such as there is conditioning to improve cancer patient illness, improve the plant enzyme of life quality effect；3. the low molecule in the plants such as fruit
Sugar and polysaccharide majority can not be utilized, it is impossible to be converted into the oligosaccharide of given efficacy.For the deficiency, applicant puts forth effort research
With shortening ferment preparation time, fermentation composition easy to use and that there is conditioning improvement cancer patient illness effect, i.e. ferment
Element bag；Simultaneously for improve ferment feature, added in the ferment fermentate of prior art effective integration of drinking and medicinal herbs food materials into
Point, its ferment prepared is effectively adjusted gut flora, strengthen immunity, and there is function.
The content of the invention
It is contemplated that at least solving one of technical problem present in prior art.Therefore, one object of the present invention
It is to propose that a kind of prepare improves cancer patient illness with conditioning, the fermentation composition of life quality effect improved, to deliver directly
Probiotics and functional oligose are used in combination formula fermenting agent, the fermentation composition, at the same add integration of drinking and medicinal herbs food materials into
Point, make said composition while with good gut flora regulatory function, small molecular sugar and polysaccharide can be promoted to low
The conversion of glycan.Plant enzyme prepared by the fermentation composition, which plays conditioning, improves effect of cancer patient illness, and cancer is suffered from
Person has effects that to improve life quality.
Technical scheme is as follows：
A kind of fementative composition prepared with conditioning improvement cancer patient illness, the plant enzyme for improving life quality effect
Thing, is direct putting type plant enzyme fermenting agent, and the fermentation composition includes the component of following parts by weight：Polysaccharide 0.5~15
0.01~10 part of part, 3~22 parts of functional oligose, 0.1~5 part of probiotics and integration of drinking and medicinal herbs food materials,
Wherein, the polysaccharide is yeast beta-dextran；
The integration of drinking and medicinal herbs food materials is mainly prepared from by the raw material of following parts by weight：10~45 parts of acerola concentrate powder with
And 8~30 parts of Antrodia camphorata；
The preparation method of the fermentation composition at least comprises the steps：
The uniform mixing of fine powder that the polysaccharide, functional oligose and integration of drinking and medicinal herbs food materials of predetermined weight number are made is killed
Bacterium, is well mixed after sterilization with probiotic powder, granulation, and the fermentation composition of powdery is made.
In the program, the functional oligose is low selected from chitosan, xylo-oligosaccharide, kanjak mannan-oligosaccharides, sweet dew
Glycan, milk ketose, raffinose, soyabean oligosaccharides, FOS, galactooligosaccharide, lactosucrose, konjac mannan sugar, sea
One or more in algae sugar, palatinose and inulin；
Probiotics is selected from Bifidobacterium (Bifidobacterium), Lactobacillus rhamnosus (L.rhamnosus), cheese breast
Bacillus (Lactobacillus casei), lactobacillus acidophilus (L.acidophilus), Lactobacillus plantarum (Lactobacillus
Plantarum), Lactobacillus salivarius (Lactobacillus salivarius), Lactobacillus helveticus (Lactobacillus
Helveticus), Bu Shi lactobacillus (Lactobacillus buchneri), lactobacillus bulgaricus
(Lactobacillus.Bulgaricus), lactobacillus paracasei (Lactobacillus paracasei) and the newborn bars of Luo Yishi
One or more in bacterium (Lactobacillus reuteri).
Probiotics and functional oligose reasonable combination are used, and both have mutual promoting action, can be doubled to enteron aisle
The regulatory function of flora, so that the effect based on gut flora plays more preferable strengthen immunity；And combining yeast beta glucan
Use can effective adjusting body digested road Tiny ecosystem, promote the excretion of nuisance in the propagation and enteron aisle of internal beneficial bacterium；
Internal cholesterol level can be reduced, internal low-density lipoprotein content is reduced, and increase the content of HDL；It can improve
The ability of the infection such as body resistance virus, bacterium.Coordinate the use of acerola concentrate powder and Antrodia camphorata, conditioning, which can be achieved, improves cancer
Disease patient symptom, the effect for improving life quality.On the other hand, powdery is made in fermentation composition, implementation phase formula is produced, just
In the later stage direct plunge into use or family oriented use.
Further, the integration of drinking and medicinal herbs food materials also raw material including following weight parts is prepared from：3~20 parts of Fu
Siberian cocklebur, 2~18 parts of matrimony vine, 3~20 parts of mulberries, 1~10 part of white fungus, 3~20 parts of jujube and 2~14 parts of dent
Amaranth.
Further, the fermentation composition by parts by weight for 2~6 parts yeast beta-dextran, 5~10 parts of function
Property oligosaccharide, the integration of drinking and medicinal herbs food materials extract composition of 1~3 part of probiotics and 0.5~1 part；
Wherein, the integration of drinking and medicinal herbs food materials is prepared from by the raw material of following parts by weight：20~35 parts of acerola concentrate powder,
16~22 parts of Antrodia camphorata, 9~15 parts of Poria cocos, 6~12 parts of matrimony vine, 9~15 parts of mulberries, 4~7 parts of white fungus, 6~12
The jujube of part and 5~8 parts of purslane.
The preferred scheme of the fermentation composition of the present invention, in addition to the resistant dextrin that parts by weight are 10~30 parts, resistance
Dextrin is used in conjunction with other components, further promotes intestines peristalsis, keeps intestinal health, and control the absorption of grease and sugar.
Further, the functional oligose is FOS；
The probiotics is probiotics powder agent, is uniformly mixed by the pulvis of following parts by weight：Bifidobacterium 45~
23~30 parts of 60 parts, 20~28 parts of lactobacillus reuteri, 12~16 parts of Lactobacillus casei and Lactobacillus plantarum, the probiotics
The viable bacteria content of pulvis is 2 × 106~2 × 1010cfu/g；By all kinds of strains of reasonable disposition and consumption, optimize this patent product
The strain of texture, can effectively shorten fermentation composition in the time for preparing plant enzyme, and it can be made to prepare texture stabilization
Plant enzyme.
The source of above-mentioned all kinds of probiotics powder agents：It is the pulvis of commercially available all kinds of strains or by will be commercially available all kinds of
Strain is collected by centrifugation with after washing thalline, drying is prepared into active powder through Liquid Culture.
In the one of preferred scheme of fermentation composition of the present invention, it is 1 that the fermentation composition, which also includes parts by weight,
~3 parts of saccharomycete, 1~3 part of acetobacter and 1~5 part of lactic acid bacteria；
The preparation method of the fermentation composition also includes：
(1) softwood is made in the fermentation composition of the powdery of 1/2 amount, is well mixed with the lactic acid bacteria of the parts by weight
Extrusion is carried out afterwards and makes ball, and capsule core is made；
(2) fermentation composition of the powdery of 1/2 amount is mixed with the saccharomycete and acetobacter of the parts by weight
It is even, softwood thing is made, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce
Pellet fermentation composition；
Wherein, the coating solution is by 100-55,0.1-2 parts of Eudragit L that parts by weight are 0.4-10 parts
Hydroxypropyl Methylcellulose Phathalate and 0.05-0.2 parts of castor oil add the aqueous dispersion that appropriate purified water is configured to.
The preparation method of fermentation composition of the present invention, comprises the following steps：
1) preparation of integration of drinking and medicinal herbs food materials：
The Antrodia camphorata and Poria cocos of the parts by weight are crushed respectively, 60 mesh sieves are crossed, Antrodia camphorata powder and Indian Bread is made；
Matrimony vine, mulberries, white fungus, jujube, the purslane of Antrodia camphorata powder, Indian Bread powder and predetermined weight part are used 8
The water of times weight, keeps 4h at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus the alcohol reflux that 2 times of weight concentrations are 75%
4h, filtering, obtains the first filtrate；The water of 3 times of weight of filter residue is added, 2.5h is kept at 80-90 DEG C of temperature, is then cooled to 30
DEG C, filtering, the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, and low-temperature grinding is into coarse powder；
Coarse powder is well mixed with acerola concentrate powder, continues to be ground into 0.05-0.2mm fine powder；2) by step 1) in
Fine powder carries out the high speed shear that 3000-5000 turns with cutter after being mixed with emulsifying agent, water, wall material monomer is added dropwise while stirring and enters
Row wall building, forms nano level particulate；3) by the functional oligose, yeast beta-dextran, resistant dextrin of predetermined weight number
With step 2) in particulate uniformly mix, sterilized by heat exchanger, condition be 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed dry
Method comminutor is granulated, and the fermentation composition of powdery is made, and sterile packing is produced.
Fermentation composition viable bacteria rate prepared by the above method is high, the traditional Chinese medicine fine powder delicate mouthfeel of particulate processing, Chinese medicine particulate
The capsule heart is slowly discharged, with good slow release effect by processes such as dissolving, infiltration, diffusions through membranous wall.
A further object of the present invention is to provide a kind of with conditioning improvement cancer patient symptom, raising life quality effect
Plant enzyme, formulated for personal or Homemade plant enzyme, the preparation method of the plant enzyme includes following
Step：
(a) powdery fermentation composition is prepared
(b) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, adds 5
~6L pure water, be well mixed, while add weight be 20~50g the step of (a) prepare fermentation composition to ferment bucket
Interior, capping carries out lucifuge fermentation in fermentation temperature is 28~30 DEG C of environment；
(c) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 5~8d of fermentation, filtering, i.e.,
Obtain plant enzyme.
This method simple and fast, realizes the self-control of various functions plant enzyme, and this method preferably uses ferment bucket and made
Standby, ferment bucket is from market sale；Also the vessel of closed environment can be used to be prepared.
Another preferred scheme of the preparation method of plant enzyme of the present invention, the described method comprises the following steps：
A) fermentation composition of powdery is prepared
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, leather
It is several in Lan Shi lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28
~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not
Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Which is applied to industrial production, with reference to the secondary of plant enzyme stoste first fermentation and fermentation composition of the present invention
Multistage deep layer liquid state fermentation is realized in fermentation；Greatly improve fermentation efficiency.It can release in fermentation process and be enclosed in Chinese medicine or plant
Structure and intracellular nutrients element, retain the original active material of plant, insoluble fibre is changed into solvable in plant
Property dietary fiber improve effect of original plant.
The preferred scheme of the preparation method of another plant enzyme, the use of the fermentation composition also constructed for double-deck pellet
Method, the preparation method comprises the following steps：
I the fermentation composition of pellet) is prepared
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of 1kg weight is added into plant material, and
10L pure water is added, is well mixed, is stood after 1~2d of extraction, high-temperature sterilization is carried out, filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g,
8L water and plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, in closed environment carry out
Fermentation；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, daily ventilation
2-4 times, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
This method simple and fast, realizes the self-control of various functions plant enzyme, and fermentation process is simply deep, once-through operation
Realize second order fermentation, or even multistage fermentation；The plant enzyme rich in nutrition content being prepared into, human absorptivity is high, further carries
Its high effect.
The present invention has the following advantages that compared with prior art：
The fermentation composition that the present invention is developed is novel fermentation product, is for preparing ferment " fermentation bacterium bag ", improveing
Direct addition probiotics prepares the traditional handicraft of plant enzyme, and the bacterium bag is easy to use, can directly with the bacterium bag of pulvis in city
Sold on face, can also put into the industrialized production of all kinds of plant enzymes, realize matching somebody with somebody i.e. with the work(with diversification for plant enzyme
Energy property configuration, is greatly enhanced the preparation efficiency of plant enzyme.
The integration of drinking and medicinal herbs food materials component added in the fermentation composition of the present invention has its physiologically active and health-care effect, together
When is supplemented the nutrients in fermentation for probiotics, with higher practical value, and the integration of drinking and medicinal herbs food materials composition of the present invention is nursed one's health
Improve cancer patient symptom, improve life quality effect；Probiotics, functional oligose and integration of drinking and medicinal herbs food materials each group divide it
Between compatibility rationally, curative effect clearly, the effect with Synergistic.
The plant enzyme of the present invention meets requirement and the development trend of health products, and plant enzyme can be produced largely to be had to human body
The comprehensive plant enzyme of benefit, metabolism and function adjustment of these enzymes to human body plays an important role, while also containing vitamin, mineral
The nutritional ingredients such as matter, amino acid, organic acid, oligosaccharide.The present invention is fermented by adding above-mentioned fermentation composition, fermentation group
Integration of drinking and medicinal herbs food materials composition in compound is changed through probiotics, is become small molecule by macromolecular, is easily absorbed by the body；Probiotics
Addition can improve toxicity can be decomposed in integration of drinking and medicinal herbs food materials taste, fermentation process, realization really has no toxic side effect, simultaneously this
Plant enzyme prepared by fermentation composition improves drug effect, the reduction of energy highly significant compared to traditional integration of drinking and medicinal herbs food materials
The content of serum total cholesterol, triglycerides in blood, increases hdl level, adjusts gut flora.The plant
Ferment, which is used to nurse one's health, improves cancer patient illness, and it takes as daily drinks, and lipid-metabolism is improved from the angle effected a permanent cure, and improves
Body immunity etc., realizes the purpose of health care.
In addition, the technical process that the direct addition of fermentation composition prepares plant enzyme is simple, it is with low cost, it is easy to accomplish big
Large-scale production, compared to prior art, shortens the time for preparing and fermenting, and safe preparation process.
The source of the integration of drinking and medicinal herbs food materials material composition of the present invention：
Acerola concentrate：For Malpighiaceae (Malpighiaceae) Malpighia (Malpighia) concave edge Malpighia coccigera
(M.emarginata) fruit.The present invention uses commercially available acerola concentrate powder.
Antrodia camphorata：Also known as cinnamomum kanahirai hay mushroom, belong to Aphyllophorales, Polyporaceae, antrodia karst, perennial gill fungus mushroom, latin name
For Antrodia camphorata.
Poria cocos：This product is On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf dry sclerotia.
Matrimony vine：This product is plant of Solanaceae lycium barbarum Lycium barbarum L. dry mature fruit.
Mulberries：This product is moraceae plants mulberry Morus alba L. drying fruit ear.
White fungus：Mycophyta Tremellaceae white fungus platymiscium white fungus Tremellafuciformis Berk. are used as medicine with fructification.
Jujube：This product is Rhamnaceae jujube jujube Ziziphus jujuba Mill.var.inermis (Bunge)
Rehd. dry mature fruit.
Purslane：This product is portulacaceous plant purslane Portulaca oleracea L., with all herbal medicine.
Embodiment
The fermentation composition of embodiment 1
The prescription of the fermentation composition of the present embodiment is：
Polysaccharide：Yeast beta-dextran 48g；
Functional oligose：FOS 80g；
Probiotics powder agent：24g, wherein containing 4.5 parts of Bifidobacterium, 2 parts of lactobacillus reuteri, cheese in per g probiotic powders
2.3 parts of 1.2 parts of lactobacillus and Lactobacillus plantarum；
Integration of drinking and medicinal herbs food materials composition：8g, is formed wherein being extracted per g extracts by the raw material of following portions by weight：Needle cherry
2 parts of peach powder, 1.6 parts of Antrodia camphorata, 0.9 part of Poria cocos, 0.6 part of matrimony vine, 0.9 part of mulberries, 0.4 part of white fungus, 0.6 part of jujube and dent
0.5 part of amaranth；
Resistant dextrin 80g.
Preparation method：
1) preparation of integration of drinking and medicinal herbs food materials：
The Antrodia camphorata and Poria cocos of the parts by weight are crushed respectively, 60 mesh sieves are crossed, Antrodia camphorata powder and Indian Bread is made；
Matrimony vine, mulberries, white fungus, jujube, the purslane of Antrodia camphorata powder, Indian Bread powder and predetermined weight part are used 8
The water of times weight, keeps 4h at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus the alcohol reflux that 2 times of weight concentrations are 75%
4h, filtering, obtains the first filtrate；The water of 3 times of weight of filter residue is added, 2.5h is kept at 80-90 DEG C of temperature, is then cooled to 30
DEG C, filtering, the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, and low-temperature grinding is into coarse powder；
Coarse powder is well mixed with acerola concentrate powder, continues to be ground into 0.05-0.2mm fine powder；
2) by step 1) in fine powder mixed with emulsifying agent, water after carried out with cutter 3000-5000 turn high speed shear,
Wall material monomer is added dropwise while stirring and carries out wall building, nano level particulate is formed；
3) by the functional oligose of predetermined weight number, yeast beta-dextran, resistant dextrin and step 2) in particulate
Uniform mixing, is sterilized by heat exchanger, and condition is 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed dry
Method comminutor is granulated, and the fermentation composition of powdery, sterile pack, every bag of 30g is made.
The fermentation composition of embodiment 2
The prescription of the fermentation composition of the present embodiment is：
Polysaccharide：Yeast beta-dextran 40g
Functional oligose：FOS 100g
Probiotics powder agent：20g, wherein 6 parts of Bifidobacterium, 2.8 parts of lactobacillus reuteri, cheese breast in per g probiotic powders
3 parts of 1.6 parts of bacillus and Lactobacillus plantarum；
Integration of drinking and medicinal herbs food materials composition：10g, is formed wherein being extracted per g extracts by the raw material of following portions by weight：Needle cherry
3.5 parts of peach powder, 2.2 parts of Antrodia camphorata, 1.5 parts of Poria cocos, 1.2 parts of matrimony vine, 1.5 parts of mulberries, 0.7 part of white fungus, 1.2 parts of jujube and horse
0.8 part of bitterroot.
Preparation method：
1) preparation of integration of drinking and medicinal herbs food materials：
The Antrodia camphorata and Poria cocos of the parts by weight are crushed respectively, 60 mesh sieves are crossed, Antrodia camphorata powder and Indian Bread is made；
Matrimony vine, mulberries, white fungus, jujube, the purslane of Antrodia camphorata powder, Indian Bread powder and predetermined weight part are used 8
The water of times weight, keeps 4h at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus the alcohol reflux that 2 times of weight concentrations are 75%
4h, filtering, obtains the first filtrate；The water of 3 times of weight of filter residue is added, 2.5h is kept at 80-90 DEG C of temperature, is then cooled to 30
DEG C, filtering, the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, and low-temperature grinding is into coarse powder；
Coarse powder is well mixed with acerola concentrate powder, continues to be ground into 0.05-0.2mm fine powder；
2) by step 1) in fine powder mixed with emulsifying agent, water after carried out with cutter 3000-5000 turn high speed shear,
Wall material monomer is added dropwise while stirring and carries out wall building, nano level particulate is formed；
3) by the functional oligose, yeast beta-dextran and step 2 of predetermined weight number) in particulate uniformly mix,
Sterilized by heat exchanger, condition is 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed dry
Method comminutor is granulated, and the fermentation composition of powdery, sterile pack, every bag of 30g is made.
The fermentation composition of embodiment 3
The prescription of the fermentation composition of the present embodiment is：
Polysaccharide：Yeast beta-dextran 10g
Functional oligose：FOS 60g
Probiotics powder agent：2g, wherein containing 5.8 parts of Bifidobacterium, 2.4 parts of lactobacillus bulgaricus, thermophilic in per g probiotic powders
2.6 parts of 2.4 parts of Lactobacillus lactis and lactobacillus paracasei；
Integration of drinking and medicinal herbs food materials composition：0.2g, is formed wherein being extracted per g extracts by the raw material of following portions by weight：Needle
1 part of cherry powder, 0.8 part of Antrodia camphorata, 0.3 part of Poria cocos, 0.2 part of matrimony vine, 0.3 part of mulberries, 0.1 part of white fungus, 0.3 part of jujube and horse
0.2 part of bitterroot；
Resistant dextrin：200g.
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 4
The prescription of the fermentation composition of the present embodiment is：
Polysaccharide：Yeast beta-dextran 150g
Functional oligose：Chitosan 104g, mannan-oligosaccharides 116g；
Probiotics powder agent：50g, wherein in per g probiotic powders containing 5.5 parts of Bifidobacterium, 2.4 parts of lactobacillus bulgaricus,
2.4 parts of 1.7 parts of lactobacillus acidophilus and Lactobacillus plantarum；
Integration of drinking and medicinal herbs food materials composition：100g, is formed wherein being extracted per g extracts by the raw material of following portions by weight：Needle
4.5 parts of cherry powder, 3 parts of Antrodia camphorata, 2 parts of Poria cocos, 1.8 parts of matrimony vine, 2 parts of mulberries, 1 part of white fungus, 2 parts of jujube and purslane 1.4
Part；
Preparation method：Prepared according to the preparation method of embodiment 2, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 5
The prescription of the fermentation composition of the present embodiment is：
Polysaccharide：Yeast beta-dextran 80g
Functional oligose：Xylo-oligosaccharide 83g, soy oligosaccharides Icing Sugar 61g, FOS 56g；
Probiotics powder agent：20g, wherein containing 4 parts of bifidobacterium longum, 1.8 parts of Lactobacillus casei, saliva in per g probiotic powders
2.2 parts of 0.9 part of lactobacillus, 1.5 parts of lactobacillus acidophilus and Lactobacillus plantarum；
Integration of drinking and medicinal herbs food materials composition：50g, is formed wherein being extracted per g extracts by the raw material of following portions by weight：Needle cherry
3.5 parts of peach powder, 1.6 parts of Antrodia camphorata, 1.5 parts of Poria cocos, 1.2 parts of matrimony vine, 0.9 part of mulberries, 0.7 part of white fungus, 0.6 part of jujube and horse
0.8 part of bitterroot；
Resistant dextrin：300g.
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 6
The prescription of the fermentation composition of the present embodiment is：
Polysaccharide：Yeast beta-dextran 72g
Functional oligose：Xylo-oligosaccharide 43g, mannan-oligosaccharides 40g, FOS 23g, galactooligosaccharide 22g and
Trehalose 19g；
Probiotics powder agent：10.1g, wherein containing 2.3 parts of bifidobacterium breve, 2 parts of bifidobacterium lactis, mouse in per g probiotic powders
2.4 parts of lactobacillus of Lee's sugar, 1.3 parts of Lactobacillus helveticus, 1 part of Bu Shi lactobacillus, 1.7 parts of lactobacillus bulgaricus and secondary cheese breast
0.9 part of bacillus；
Integration of drinking and medicinal herbs food materials composition：4.55g, is formed wherein being extracted per g extracts by the raw material of following portions by weight：Needle
2.1 parts of cherry powder, 1.3 parts of Antrodia camphorata, 0.8 part of Poria cocos, 1.2 parts of matrimony vine, 1 part of mulberries, 0.9 part of white fungus, 1.6 parts of jujube and horse
1.2 parts of bitterroot；
Resistant dextrin 70.5g.
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 7
Polysaccharide：Yeast beta-dextran 48g；
Functional oligose：FOS 80g；
Probiotics powder agent：24g, wherein containing 4.5 parts of Bifidobacterium, 2 parts of lactobacillus reuteri, cheese in per g probiotic powders
2.3 parts of 1.2 parts of lactobacillus and Lactobacillus plantarum；
Integration of drinking and medicinal herbs food materials composition：8g, is formed wherein being extracted per g extracts by the raw material of following portions by weight：Needle cherry
2 parts of peach powder, 1.6 parts of Antrodia camphorata.
Preparation method：
1) preparation of integration of drinking and medicinal herbs food materials：
The Antrodia camphorata and Poria cocos of the parts by weight are crushed respectively, 60 mesh sieves are crossed, Antrodia camphorata powder is made, with acerola concentrate
Powder is well mixed, and continues to be ground into 0.05-0.2mm fine powder；
2) by step 1) in fine powder mixed with emulsifying agent, water after carried out with cutter 3000-5000 turn high speed shear,
Wall material monomer is added dropwise while stirring and carries out wall building, nano level particulate is formed；3) by the functional oligose of predetermined weight number,
Yeast beta-dextran and step 2) in particulate uniformly mix, sterilized by heat exchanger, condition be 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed dry
Method comminutor is granulated, and the fermentation composition of powdery, sterile pack, every bag of 30g is made.
The fermentation composition of embodiment 8
The pulvis fermentation composition 32g that embodiment 1 is made；Saccharomycete 1g；Acetobacter 1g；Lactic acid bacteria 1g；Coating solution by
Eudragit L 100-5520g, Hydroxypropyl Methylcellulose Phathalate 5g and the appropriate purifying of castor oil 2.5g additions
Water is prepared；
Preparation method：
(1) softwood is made in the pulvis fermentation composition of 1/2 amount, after being well mixed with the lactic acid bacteria of the parts by weight
Carry out extrusion and make ball, capsule core is made；
(2) the pulvis fermentation composition of 1/2 amount is well mixed with the saccharomycete and acetobacter of the parts by weight,
Softwood thing is made, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce
Pellet fermentation composition, packaging.
Wherein obtained pellet diameters are 4-7mm, a diameter of 2-5mm of capsule core；It is preferred that pellet diameters 5mm, capsule core is a diameter of
2.8mm。
The fermentation composition of embodiment 9
The prescription of the fermentation composition of the present embodiment is：
The pulvis fermentation composition 23.1g that embodiment 3 is made；Saccharomycete 3g；Acetobacter 3g；Lactic acid bacteria 5g；Coating solution
It is appropriate pure by Eudragit L 100-5510g, Hydroxypropyl Methylcellulose Phathalate 2g and castor oil 0.2g addition
Change water to prepare；
Preparation method：
(2) softwood is made in the pulvis fermentation composition of 1/2 amount, after being well mixed with the lactic acid bacteria of the parts by weight
Carry out extrusion and make ball, capsule core is made；
(2) the pulvis fermentation composition of 1/2 amount is well mixed with the saccharomycete and acetobacter of the parts by weight,
Softwood thing is made, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce
Pellet fermentation composition, packaging.
Wherein obtained pellet diameters are 4-7mm, a diameter of 2-5mm of capsule core；It is preferred that pellet diameters 5mm, capsule core is a diameter of
2.8mm。
The plant enzyme of embodiment 10
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition:Prepared according to the fermentation composition of embodiment 1；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 2 months, obtains plant enzyme stoste；
Wherein inoculum concentration is 12%；Composite flora is Lactobacillus plantarum, gram lactobacillus, lactobacillus acidophilus and acetic acid
In bacillus；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28
~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not
Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g, and clean section is used.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 11
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 2；
B) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added
In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract
Liquid；
C) mixing and initial fermentation：Add plant of fermentation composition of the weight for 60g step a) preparations into step b)
In thing extract solution, mixing is placed in closed environment, keeps 28 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
D) zymotic fluid carries out after-ripening 7d in closed environment, filtering, produces plant enzyme.
Wherein, plant material selects Kiwi berry 100g, strawberry 90g, hawthorn 40g, mango 220g, carrot 80g, ternip
140g, Chinese cabbage 150g, agaric 80g and mushroom 100g.
Organoleptic parameters：The plant enzyme uniform color, between buff and brown, having, strong fruity and fermentation are fragrant
Gas, mellow in taste, comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 12
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 3；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 1 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, leather
It is several in Lan Shi lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28
~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not
Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Wherein, plant material selects passion fruit 120g, citrus 200g, grape 100g, Chinese yam 50g, pumpkin 220g, celery
40g, water spinach 50g, bean sprouts 50g, sea-tangle 60g, seaweed 40g and asparagus 70g.
Organoleptic parameters：The plant enzyme uniform color, in dark brown, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 13
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 5；
B) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added
In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract
Liquid；
C) mixing and initial fermentation：The fermentation composition for the step a) preparations that weight is 30~60g is added into step b)
Plant extraction liquid in, mixing is placed in closed environment, keeps 30 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
D) zymotic fluid carries out after-ripening 7d in closed environment, filtering, produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 14
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 1；
B) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, addition 5~
6L pure water, is well mixed, while add in fermentation composition to the ferment bucket that weight is prepared for 20~50g step a),
Capping, lucifuge fermentation is carried out in fermentation temperature is 28~30 DEG C of environment；
C) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 4~6d of fermentation, filtering is produced
Plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 15
The plant enzyme of the present embodiment is prepared from by following methods：
I the fermentation composition of pellet) is prepared according to embodiment 8
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of 1kg weight is added into plant material, and
10L pure water is added, is well mixed, is stood after 1~2d of extraction, high-temperature sterilization is carried out, filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g,
8L water and plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, in closed environment carry out
Fermentation；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, daily ventilation
2-4 times, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
Observation to the pellet fermentation composition fermentation process of embodiment 8：Pellet fermentation composition during the fermentation, ball
The outer layer component of grain dissolves rapidly in the solution, and subsequent capsule core dissolving is slow, and coating membrane fades away after about 1-2d, and capsule core is completely molten
Solution.
The fermentation composition of comparative examples 1
The prescription of the fermentation composition of the present embodiment is：：
Polysaccharide：Yeast beta-dextran 48g；
Functional oligose：FOS 80g；
Probiotics powder agent：24g, wherein containing 4.5 parts of Bifidobacterium, 2 parts of lactobacillus reuteri, cheese in per g probiotic powders
2.3 parts of 1.2 parts of lactobacillus and Lactobacillus plantarum；
Resistant dextrin 80g.
Preparation method：
1) functional oligose, yeast beta-dextran, resistant dextrin of predetermined weight number are uniformly mixed, passes through heat exchange
Device is sterilized, and condition is 99 DEG C, 300s；
2) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed dry
Method comminutor is granulated, and the fermentation composition of powdery, sterile pack, every bag of 30g is made.
The plant enzyme of comparative examples 2
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared by the fermentation composition of comparative examples 1；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after extraction 2d, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 12%；Composite flora is Lactobacillus plantarum, gram lactobacillus, lactobacillus acidophilus and acetic acid
In bacillus；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28
~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not
Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
The plant enzyme of comparative examples 3
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added
In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract
Liquid；
B) mixing and initial fermentation：It is inoculated with plant extraction liquid of the compound probiotic into step b), mixing is placed in closed
Environment, keeps 30 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
C) zymotic fluid carries out after-ripening 7d in closed environment, takes Partial fermentation liquid to filter, does organoleptic parameters；Continue after-ripening
14d, takes Partial fermentation liquid to filter, does organoleptic parameters.
Wherein, compound probiotic be Bifidobacterium, Lactobacillus rhamnosus, Lactobacillus casei,
Lactobacillus acidophilus and Lactobacillus plantarum；Inoculum concentration is 8% (mass percent)；
Plant material selects apple 500g, soybean 200g and tomato 300g.
The organoleptic parameters of zymotic fluid after 7 days：The plant enzyme color and luster is in bronzing, and tissue mobility is big, entrance slightly has
Stimulation, sweet taste are heavier；The organoleptic parameters of zymotic fluid after 14 days：The plant enzyme uniform color, in bronzing, there is strong
Fruity is not stimulated with fermentation fragrance, mellow in taste, comfortable acid, entrance, and pleasant impression is sweet.Understand, plant prepared by conventional method
The fermentation time that ferment needs is longer than the fermentation time of the embodiment of the present invention.
Comparative examples 4
The prescription of the fermentation composition of the present embodiment is same as Example 1
Fermentation composition preparation method：
(1) according to the step 1 of embodiment 1) prepare integration of drinking and medicinal herbs food materials：
(2) by the integration of drinking and medicinal herbs food materials of predetermined weight number, functional oligose, yeast beta-dextran, probiotics powder agent,
Resistant dextrin is uniformly mixed, and mixed powder is added into dry granulating machine granulation, and the granule of fermentation composition, pack, every bag is made
30g。
Plant enzyme preparation method：Method according to embodiment 10 is prepared into plant enzyme.
(2) organoleptic parameters：The plant enzyme color and luster is uneven, muddy, has floating object, in bronzing, fruit flavor is thin, entrance
Do not stimulate.
The viable bacteria survival detection of the fermentation composition of test example 1
Fermentation composition prepared by the embodiment of the present invention 1, embodiment 8 and comparative examples 4, is prepared with sterilized water and survived
Bacterium number is 2 × 108CFU/mL solution to be measured, is saved backup in 4 DEG C；
The 10mL kept the solution to be measured of going bail for is injected into test tube 1, and 10 are diluted to step by step using ten times-8, take 1mL to dilute
The MRS agar mediums that 45 DEG C are cooled to after sterilizing are poured on flat board (sterilizing), shaken up rapidly on flat board by liquid.Again will
The test tube 2 of solution to be measured equipped with 10mL, which is placed in 80-90 DEG C of water-bath, heats 15-25min, takes the solution to be measured after heating to enter
Row ten is diluted to 10 step by step again-8, 1mL dilutions are taken on flat board, and the MRS agar mediums that 45 DEG C are cooled to after sterilizing are poured into
Shake up on flat board (sterilizing) and rapidly.Flat board before finally heating and after heating cultivates 24h under the conditions of 35 DEG C, calculates
Number of viable before and after heating.
As a result show, Viable detection is respectively 90%, 89% and 61.3%.
The viable bacteria survival detection of the plant enzyme of test example 2
1st, simulate the gastric juice and the resistance test of intestinal juice
100g/L hydrochloric acid 16.4mL plus distilled water diluting is taken, it is respectively 1.5,2.5 and 3.5 to make pH value, take the dilute salt of 100mL
Acid solution, is separately added into 1g pepsins, it is fully dissolved, and obtains simulate the gastric juice, and miillpore filter degerming (0.22 μm) is standby.Take
Potassium dihydrogen phosphate 6.8g, the 500mL that adds water makes dissolving, and pH value is adjusted to 6.8 with 0.1moL/L sodium hydroxide solutions；Separately take tryptose
Enzyme 10g, the 100mL that adds water makes dissolving, after two liquid are mixed, is diluted with water to 1000ml, obtains simulated intestinal fluid, miillpore filter is degerming
(0.22 μm) is standby.
The plant enzyme solution of embodiment 10 that 1mL is kept and the present invention of embodiment 15 is taken to be added to 9mL simulation stomach
In liquid (i.e. ten times dilute step by step), and rapid fully mixing on the oscillator, it is subsequently placed in 30-45 DEG C of quiescent culture 2-4h.Point
Nutrient solution is not taken out when 1h, 2h, 3h, 4h and remaining viable count is counted immediately, is compared with former viable count, as a result table
Bright, Viable detection is respectively 98% and 99%.Then each 1mL of nutrient solution that different time is digested in simulated gastric fluid is taken, point
It is not inoculated in the simulated intestinal fluid that 9mL pH value is 6.8, is placed in 30-45 DEG C of quiescent culture 2-4h, and taken respectively in 0,3,6,24h
Sample, determines its viable count, is compared with former viable count, and it is 99% as a result to show Viable detection.
The human experiment evaluation of the plant enzyme treating cancer of test example 3
1. the test example of plant enzyme anticancer total effectses of the present invention
By meet pathology or cytology is made a definite diagnosis be in hospital and outpatient service tumor patient totally 121, using plant of the invention
Ferment, the record course for the treatment of is 6 months, and each 30ml warm waters dilution is edible, 2 times/day, the life of 6 months to 5 years of Ureteral Calculus curative effect
Deposit quality.
1.2. efficacy assessment standard：
Complete incidence graph (CR)：It can be seen that carcinoma is wholly absent, continue more than one month, no recurrence or transferrer.
Alleviate (PR) in part：The product of carcinoma maximum gauge and its perpendicular diameter reduces ＞ 50%, continues more than one month
Person.
Stable (S)：The product of carcinoma maximum gauge and its perpendicular diameter reduces ＜ 50% or stablizes constant, other focuses without
Increase continues more than one month person.
1.3. evaluation result：
1.3.1 efficient observation
Observe result：70.2% patient body weight increase, 81% patient clinical symptom is alleviated or disappeared, especially after the treatment
Improve obvious with weak, hidrosis, dry, the symptoms such as difference of receiving.
1.3.2 survival rate is observed
Observe result：It is 28.7% to treat various malignant tumour five year survival rates.
1.3.3 with chemotherapeutics anticancer therapeutic
Result of the test：
The plant enzyme of embodiments of the invention 10 is suppression of 39.4%, the 5-Fu to malignant tumour to malignant tumour inhibiting rate
Rate is 41.1%, and the plant enzyme of embodiments of the invention 10 is simultaneously 59.2% using inhibiting rate with 5-Fu.
The plant enzyme of the present invention is with chemotherapeutics simultaneously using the effect for serving attenuation synergistic.Bone can not only be protected
Marrow hemopoietic system, and body's immunity can be improved, improve life in patients.
The Tumor Patient Before and After Treatment blood picture of table 1 and changes in immune function situation
| Inspection project | Number of cases | X ± SD before treatment | X ± SD after treatment | P values |
| Leucocyte | 121 | 3574±40.0 | 7083±192.8 | P ＜ 0.01 |
| Blood platelet | 121 | 98.51±0.664 | 180.81±0.539 | P ＜ 0.05 |
| E- roseleaf formation rates | 121 | 44±1.27 | 49.6±1.33 | P ＜ 0.01 |
| Lymphocyte proliferation test | 121 | 59.41±1.41 | 61.81±1.42 | P ＜ 0.05 |
Shown by the result of table 1：There is notable difference to illustrate that the plant enzyme of the present invention can show before and after four kinds of index treatments
Write and improve tumor patient hematopoiesis function and cellular immune function, improve life quality.
1.4. clinical observation is verified
Checked UP before and after being taken in the patient for take this medicine, observation blood pressure, the heart, lung, and do liver function and routine urinalysis
Chemical examination, prove unchanged, i.e., the present invention Chinese medicine composition to the heart, lung, kidney, liver etc. without overt toxicity.
Mr. Wang, female 61 years old, suffers from lung cancer 0.5 year, and symptom is cough, low-heat, pectoralgia；Take the plant enzyme of the present invention, day
Take 3 times, each 10ml, 3 months state of an illness of medication have taken a turn for the better, and take after 1 year, tumor disappearance, be so far recurrence.
Song, man, 59 years old, suffers from cardia cancer 1 year, and food has peculiar sense, severe pain, has a sense of obstruction, slight pit of the stomach often
Bitterly；Through multi-treatment fail cure, after take the present invention plant enzyme, take day 3 times, each 10ml takes symptom after 2 months
Substantially mitigate, continue to take 6 months, symptom is wholly absent.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not
In the case of departing from the principle and objective of the present invention a variety of change, modification, replacement and modification can be carried out to these embodiments, this
The scope of invention is limited by claim and its equivalent.
Claims (10)
1. a kind of fementative composition prepared with conditioning improvement cancer patient illness, the plant enzyme for improving life quality effect
Thing, it is characterised in that the fermentation composition is direct putting type plant enzyme fermenting agent, the fermentation composition includes following weight
The component of number：0.5~15 part of polysaccharide, 3~22 parts of functional oligose, 0.1~5 part of probiotics and integration of drinking and medicinal herbs food materials
0.01~10 part,
Wherein, the polysaccharide is yeast beta-dextran；
The integration of drinking and medicinal herbs food materials is mainly prepared from by the raw material of following parts by weight：10~45 parts of acerola concentrate powder and 8
~30 parts of Antrodia camphorata；
The preparation method of the fermentation composition at least comprises the steps：
The fine powder that the polysaccharide, functional oligose and integration of drinking and medicinal herbs food materials of predetermined weight number are made uniformly mixes sterilization,
It is well mixed, granulates with probiotic powder after sterilization, the fermentation composition of powdery is made.
2. fermentation composition as claimed in claim 1, it is characterised in that the integration of drinking and medicinal herbs food materials extract also includes following
The raw material of parts by weight is extracted and formed：3~20 parts of Poria cocos, 2~18 parts of matrimony vine, 3~20 parts of mulberries, 1~10 part of white fungus,
3~20 parts of jujube and 2~14 parts of purslane.
3. fermentation composition as claimed in claim 2, it is characterised in that the fermentation composition is 2~6 parts by parts by weight
Yeast beta-dextran, 5~10 parts of functional oligose, 1~3 part of probiotics and 0.5~1 part of integration of drinking and medicinal herbs food materials group
Into；
Wherein, the integration of drinking and medicinal herbs food materials is prepared from by the raw material of following parts by weight：20~35 parts of acerola concentrate powder, 16~
22 parts of Antrodia camphorata, 9~15 parts of Poria cocos, 6~12 parts of matrimony vine, 9~15 parts of mulberries, 4~7 parts of white fungus, 6~12 parts
Jujube and 5~8 parts of purslane.
4. fermentation composition as claimed in claim 1, it is characterised in that it is 10 that the fermentation composition, which also includes parts by weight,
~30 parts of resistant dextrin.
5. fermentation composition as claimed in claim 1, it is characterised in that the functional oligose is FOS；
The probiotics is probiotics powder agent, is uniformly mixed by the pulvis of following parts by weight：45~60 parts of Bifidobacterium,
23~30 parts of 20~28 parts of lactobacillus reuteri, 12~16 parts of Lactobacillus casei and Lactobacillus plantarum, the probiotics powder agent
Viable bacteria content be 2 × 106~2 × 1010cfu/g。
6. the fermentation composition as any one of claim 1-5, it is characterised in that the fermentation composition also includes weight
Measure saccharomycete, 1~3 part of acetobacter and 1~5 part of lactic acid bacteria that number is 1~3 part；
The preparation method of the fermentation composition also includes：
(1) softwood is made in the fermentation composition of the powdery of 1/2 amount, is well mixed with the lactic acid bacteria of the parts by weight laggard
Row extrusion makes ball, and capsule core is made；
(2) fermentation composition of the powdery of 1/2 amount is well mixed with the saccharomycete and acetobacter of the parts by weight, made
It is standby into softwood thing；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce pellet
Fermentation composition；
Wherein, the coating solution is by the adjacent benzene for 100-55,0.1-2 parts of the Eudragit L that parts by weight are 0.4-10 parts
Dioctyl phthalate hydroxypropyl methyl cellulose and 0.05-0.2 parts of castor oil add the aqueous dispersion that appropriate purified water is configured to.
7. a kind of preparation method of fermentation composition as claimed in claim 4, it is characterised in that methods described includes following step
Suddenly：
1) preparation of Chinese medical extract：
The Antrodia camphorata and Poria cocos of the parts by weight are crushed respectively, 60 mesh sieves are crossed, Antrodia camphorata powder and Indian Bread is made；
By Antrodia camphorata powder, the matrimony vine of Indian Bread powder and predetermined weight part, mulberries, white fungus, jujube, purslane with 8 times of weights
The water of amount, 4h is kept at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus the alcohol reflux 4h that 2 times of weight concentrations are 75%,
Filtering, obtains the first filtrate；The water of 3 times of weight of filter residue is added, 2.5h is kept at 80-90 DEG C of temperature, is then cooled to 30 DEG C, mistake
Filter, the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, and low-temperature grinding is into coarse powder；
Coarse powder is well mixed with acerola concentrate powder, continues to be ground into 0.05-0.2mm fine powder；2) by step 1) in fine powder
The high speed shear that 3000-5000 turns is carried out after being mixed with emulsifying agent, water with cutter, wall material monomer is added dropwise while stirring and is made
Wall, forms nano level particulate；3) by the functional oligose of predetermined weight number, yeast beta-dextran, resistant dextrin and step
It is rapid 2) in particulate uniformly mix, sterilized by heat exchanger, condition be 99 DEG C, 300s；4) mixture is cooled to after sterilizing
40-45 DEG C, the probiotics for adding scheduled volume is freeze-dried, and dry granulating machine granulation is added after being well mixed, the fermentation of powdery is made
Composition, sterile packing is produced.
8. there is conditioning to improve cancer patient symptom, improve life quality effect any one of a kind of claim 1-5
The preparation method of plant enzyme, it is characterised in that the described method comprises the following steps：
(a) powdery fermentation composition is prepared
(b) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, adds 5~6L
Pure water, be well mixed, at the same add weight be 20~50g the step of (a) prepare fermentation composition to ferment bucket in, envelope
Lid, lucifuge fermentation is carried out in fermentation temperature is 28~30 DEG C of environment；
(c) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 5~8d of fermentation, filtering produces plant
Thing ferment.
9. there is conditioning to improve cancer patient symptom, improve life quality effect any one of a kind of claim 1-5
The preparation method of plant enzyme, it is characterised in that the described method comprises the following steps：
A) fermentation composition of powdery is prepared
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight is added into plant material
10L pure water, is well mixed, and stands after 1~2d of extraction, carries out high-temperature sterilization, and filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carries out lucifuge
Fermentation 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, gram
It is several in lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water with
And plant material 0.5kg, add 150ml plant enzyme stoste fermented in closed environment, fermentation temperature be 28~30
DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is constant, after
Supervention ferment 3-4d, filtering, produces plant enzyme.
10. there is described in a kind of claim 6 conditioning to improve cancer patient symptom, improve the plant enzyme of life quality effect
Preparation method, it is characterised in that the described method comprises the following steps：
I the fermentation composition of pellet) is prepared
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight is added into plant material
10L pure water, is well mixed, and stands after 1~2d of extraction, carries out high-temperature sterilization, and filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water
And plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, sent out in closed environment
Ferment；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, and ventilate 2-4 daily
It is secondary, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111772175A (en) * | 2019-09-10 | 2020-10-16 | 浙江康叶源健康科技有限公司 | Three-in-one nutritional food containing ferment, probiotics and yeast-beta glucan |
| CN113230339A (en) * | 2021-05-27 | 2021-08-10 | 广东省好杰宏生物医药科技有限公司 | Enzyme for treating leukemia and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757042A (en) * | 2009-05-25 | 2010-06-30 | 北京诚创康韵医药科技有限公司 | Probiotic pellet preparation and preparing method thereof |
| CN104152354A (en) * | 2013-05-14 | 2014-11-19 | 仙农生物科技(上海)有限公司 | Compound probiotics as well as production process and application thereof to leavening agent |
| CN105112329A (en) * | 2015-08-26 | 2015-12-02 | 上海普乐拜格健康科技有限公司 | Method for preparing special microbial preparations for homemade 'fruit and vegetable enzymes', products of method and application of products |
| CN106174485A (en) * | 2016-07-11 | 2016-12-07 | 佛山市朗达信息科技有限公司 | There is the enzyme composition of kidney-reinforcing Yang strengthening effect, effervescent tablet and preparation method |
-
2017
- 2017-04-11 CN CN201710233947.0A patent/CN107048408A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757042A (en) * | 2009-05-25 | 2010-06-30 | 北京诚创康韵医药科技有限公司 | Probiotic pellet preparation and preparing method thereof |
| CN104152354A (en) * | 2013-05-14 | 2014-11-19 | 仙农生物科技(上海)有限公司 | Compound probiotics as well as production process and application thereof to leavening agent |
| CN105112329A (en) * | 2015-08-26 | 2015-12-02 | 上海普乐拜格健康科技有限公司 | Method for preparing special microbial preparations for homemade 'fruit and vegetable enzymes', products of method and application of products |
| CN106174485A (en) * | 2016-07-11 | 2016-12-07 | 佛山市朗达信息科技有限公司 | There is the enzyme composition of kidney-reinforcing Yang strengthening effect, effervescent tablet and preparation method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111772175A (en) * | 2019-09-10 | 2020-10-16 | 浙江康叶源健康科技有限公司 | Three-in-one nutritional food containing ferment, probiotics and yeast-beta glucan |
| CN113230339A (en) * | 2021-05-27 | 2021-08-10 | 广东省好杰宏生物医药科技有限公司 | Enzyme for treating leukemia and preparation method and application thereof |
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