CN106490621A - A kind of probiotic composition and its application in Constipation - Google Patents
A kind of probiotic composition and its application in Constipation Download PDFInfo
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- CN106490621A CN106490621A CN201610899547.9A CN201610899547A CN106490621A CN 106490621 A CN106490621 A CN 106490621A CN 201610899547 A CN201610899547 A CN 201610899547A CN 106490621 A CN106490621 A CN 106490621A
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- probiotic composition
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- 206010010774 Constipation Diseases 0.000 title claims abstract description 40
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Classifications
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- A—HUMAN NECESSITIES
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention proposes a kind of probiotic composition and its application in Constipation, belongs to field of functional food, can effectively improve the Self-regulation ability of body, is finally reached Constipation purpose.The probiotic composition includes the raw material of following weight portion：26 parts of probiotic bacteria, 46 parts of inulin, 13 parts of Mel powder, 13 parts of Fructus Hordei Germinatus powder, 13 parts of Fructus Lycii powder.Probiotic composition provided by the present invention can be used for Constipation.
Description
Technical field
The invention belongs to field of functional food, more particularly to a kind of probiotic composition and its answering in Constipation
With.
Background technology
According to investigations, in general population, the people of 2%-27% has different degrees of constipation symptom, in the medical disease of anorectum department
In people, constipation patient accounts for more than a quarter.Constipation is common symptom of digestive tract, when showing as times of defecation minimizing, interval
Between extend, the few matter of feces amount is hard, defecation is hard, do not have happy sense of satisfaction etc. after defecation.Meanwhile, constipation also results in internal poison
Skin problem, the hemorrhoid anal fissure such as element accumulation, damage internal organs, chloasma etc., seriously also result in apoplexy, drastically influence people's
Quality of life.
At present, to symptomatic treatments such as the most employing catharsis agent of constipation, motor activation regulators, taking this kind of medicine can only be temporary transient for doctor trained in Western medicine
The symptom of reduction of patient, and side effect is more and is possible to produce drug dependence.Therefore, the prevention for constipation is actively developed,
A kind of safely and effectively product of exploitation is very necessary.
Recently medical research discovery, causes the principal element of constipation not only excessively rare with intestinal flora imbalance probioticss quantity
Close, also closely related with the Self-regulation ability of body.The reason for for example causing common working clan's constipation is mainly work strain
Busy, cause fatigue, psychentonia, body regulating power to reduce；Diet work and rest is irregular, causes intestinal environment to balance
Destroyed；Sitting is moved less, subimbition, is caused intestinal muscle to relax, is short of power, wriggling ability slows down, and ultimately results in constipation.
Therefore, how to provide a kind of based on Self-regulation ability probiotic bacteria, that body can be effectively improved, be finally reached Constipation
The product of purpose will be the important topic studied by this area.
Content of the invention
The present invention proposes a kind of probiotic composition and its application in Constipation, can effectively improve body
Self-regulation ability, is finally reached Constipation purpose.
An aspect of of the present present invention provides a kind of probiotic composition, including the raw material of following weight portion：Probiotic bacteria 2-6
Part, inulin 4-6 parts, Mel powder 1-3 parts, Fructus Hordei Germinatus powder 1-3 parts, Fructus Lycii powder 1-3 part.
Used as optional technical scheme, the probiotic bacteria is selected from lactobacillus rhamnosuss, bacillus acidophilus, lactobacillus casei, volume
Bent lactobacilluss, Deshi Lactobacilluss, Lactobacillus bulgaricus, lactobacillus helveticuss, Lactobacillus fermenti, Lactobacillus gasseri, Yue Shi breast bars
Bacterium, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus reuteri, lactobacillus rhamnosuss, Lactobacillus salivarius, bifidobacterium adolescentiss,
Animal bifidobacteria, bifidobacterium bifidum, bifidobacterium breve, bifidobacteria infantiies, bifidobacterium longum, streptococcus thermophiluss, condensation
One or more in bacillus cereuss, Haematocoocus Pluvialls, lactococcus lactis, Leuconostoc mesenteroides and yeast Kluyveromyces marxianus.
As optimal technical scheme, in every gram of probiotic composition dry weight, contain 102To 1012The probiotic bacteria of cfu, preferably
104To 1011, more preferably 105To 1010, most preferably 105To 5 × 109.
As optimal technical scheme, contain at least 5 × 10 in every gram of probiotic composition dry weight-3- 1g inulin.
As optimal technical scheme, contain at least 5 × 10 in every gram of probiotic composition dry weight-3- 0.5g Mel powder.
Used as optional technical scheme, the Mel powder is by Mel, maltodextrin, beta-schardinger dextrin -5-7 in mass ratio:2-4:
0.5-1.5 is uniformly mixed to get, and wherein, the particle diameter of the Mel powder is 20-40 mesh.
As optimal technical scheme, contain at least 5 × 10 in every gram of probiotic composition dry weight-3- 0.5g Fructus Hordei Germinatus powder.
As optimal technical scheme, contain at least 5 × 10 in every gram of probiotic composition dry weight-3- 0.5g Fructus Lycii powder.
A kind of probiotic composition as described in above-mentioned any one technical scheme be another aspect provides in system
The application being ready for use in the compositionss of prevention experimenter's constipation.
Used as optional technical scheme, the probiotic composition is in liquid form or solid-state form gives.
Compared with prior art, advantages of the present invention and good effect are：
1st, the present invention provide with can promote the production of body fluid while strengthening intestinal maneuverability, maintaining intestinal environment stable
Intestine moistening, benefit QI and blood regulating, heat clearing and tranquillizing, so as to improve the regulating power of body itself, are finally reached the purpose of Constipation；
2nd, each active component in the formula that the present invention is provided is presented with auxiliary or synergism, but mutually not antagonism,
Can be while regulating power be effectively played, it is adaptable to be configured to be suitable to the dosage forms such as the capsule of oral administration, tablet, granule
Food, health product, medicine etc..
Specific embodiment
Below the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described enforcement
Example is only a part of embodiment of the invention, rather than whole embodiment.Embodiment in based on the present invention, this area are common
The every other embodiment obtained under the premise of creative work is not made by technical staff, belongs to the model of present invention protection
Enclose.
The embodiment of one aspect of the present invention provides a kind of probiotic composition, including the raw material of following weight portion：Prebiotic
Bacterium 2-6 parts, inulin 4-6 parts, Mel powder 1-3 parts, Fructus Hordei Germinatus powder 1-3 parts, Fructus Lycii powder 1-3 part.It is understood that at above-mentioned group
In compound, as long as the amount of each component then can play identical effect within the above range, for example, probiotic bacteria can be 2,3,4,
5th, 6 parts, inulin can be 4,5,6 parts, and Mel powder can be 1,2,3 parts, and Fructus Hordei Germinatus powder can be 1,2,3 parts, and Fructus Lycii powder can be with
For 1,2,3 parts etc..The probiotic composition for including said components that the present embodiment is provided can be effectively used for strengthening intestinal machine
While kinetic force, maintenance intestinal environment are stable, intestine moistening of promoting the production of body fluid, benefit QI and blood regulating, heat clearing and tranquillizing, so that improve body itself
Regulating power, is finally reached the purpose of Constipation.Wherein, the interaction between each component for auxiliary or synergism but
Mutually not antagonism, specific as follows：
Probiotic bacteria
Modern medicine study shows, the stable of intestinal environment stably has for safeguarding intestinal environment for intestinal microbial population
Play an important role, whether particularly probiotic bacteria can become dominant microflora in intestinal microbial population and be related to that can whole intestinal normally be transported
Make.Probiotic bacteria can suppress enteral corruption probiotic bacteria to be fermented in intestinal, decompose saccharide, produce breast to anti-enterovirus
Acid or acetic acid, make enteral environment keep acid, thus suppress the hypertrophy of putrefaction bacteria, help absorb nutritional labeling.Appropriate supplementary benefit
Raw bacterium is significant to improving intestinal digestion and excretory function.
In an alternative embodiment, the probiotic bacteria is selected from lactobacillus rhamnosuss, bacillus acidophilus, lactobacillus casei, volume
Bent lactobacilluss, Deshi Lactobacilluss, Lactobacillus bulgaricus, lactobacillus helveticuss, Lactobacillus fermenti, Lactobacillus gasseri, Yue Shi breast bars
Bacterium, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus reuteri, lactobacillus rhamnosuss, Lactobacillus salivarius, bifidobacterium adolescentiss,
Animal bifidobacteria, bifidobacterium bifidum, bifidobacterium breve, bifidobacteria infantiies, bifidobacterium longum, streptococcus thermophiluss, condensation
One or more in bacillus cereuss, Haematocoocus Pluvialls, lactococcus lactis, Leuconostoc mesenteroides and yeast Kluyveromyces marxianus.
In a preferred embodiment, probiotic bacteria can be bacillus acidophilus, bifidobacterium bifidum, bifidobacterium adolescentiss, animal bifidobacteria,
One or more in lactobacillus rhamnosuss, Lactobacillus reuteri, Bacillus coagulans.In a more preferred embodiment, prebiotic
Bacterium can be one or more in bacillus acidophilus, lactobacillus rhamnosuss, bifidobacterium adolescentiss, animal bifidobacteria.
In order to ensure probiotic bacteria useful effect in the composition, in a preferred embodiment, in every gram of probiotic bacteria
Contain 10 in compositionss dry weight2To 1012The probiotic bacteria of cfu, preferably 104To 1011, more preferably 105To 1010, most preferably 105To 5
×109.
Inulin
Inulin is a kind of water-soluble fibre that can be mass-sended ferment by human microorganism.In embodiments of the present invention, inulin is determined
Justice is a kind of Non Digestible Oligosaccharides, including the chain of the fructose units of β connections that degree of polymerization (DP) is 2 to 250, more than 90%
Fructose units have β (2 → 1) bonded.The end of fructose chain can have can also be without glucose unit.Thus, inulin can
To be represented by Gfn or Fn, wherein G represents glucose elementary cell, and F represents Fructose elementary cell, and n is the fructosyl for interconnecting
The number of this unit, n are 2 or more.
In the present embodiment, the average DP values of inulin used are preferably 5-10 or more.Preferably, the average DP of inulin
It is at least 6-8 to be worth, more preferred, and the average DP values of inulin are more than 7, so as to not only improve the utilization for improving microorganism, and energy
The osmosiss of intestinal are improved, the effect of relieving constipation is finally reached.The presence of inulin selectively stimulates intestinal bacteria, is particularly benefit
The growth of raw bacterium and/or activity, this stimulation are particularly occurred in colon, so as to advantageously reduce pH value, are defined organic
Acid, so that accelerate the decomposition of food；The fiber attribute of the probiotics factor and inulin of probiotic bacteria release can stimulate intestinal peristalsis promoting：From
And accelerate intestinal contents to excrete.
In a preferred embodiment, at least 5 × 10 are contained in every gram of probiotic composition dry weight-3- 1g inulin.Specifically
, containing at least 5mg inulin, preferably at least 10mg inulin, more preferably at least 25mg chrysanthemums in every gram of probiotic composition dry weight
Powder.Preferably, contain in every g dry weights and be less than 1g inulin, more preferably no more than 0.75g inulin, more preferably not more than
0.6g inulin, most preferably not more than 0.5g inulin.
Mel powder
《Mingyi Bielu》In point out that temper supported by Mel, except vexed, aphagia；Modern medicine finds that Mel can make large intestine
Particularly colon keeps moistening, reduces large intestine and dries and cause the risk of constipation；Additionally, Mel have significant antioxidation,
Resisting fatigue, effect of enhance immunity.Therefore, Mel can not only be moisturized and while can detoxify, from improving function of intestinal canal
Reduce constipation risk with two aspects of physical stress ability are improved.
In the present embodiment, from the angle prepared beneficial to compositionss, with the Mel nutritional labeling difference in change opposite sex not
Significant Mel powder substitute for honey is added in above-mentioned composition, and wherein, Mel powder is that science is compounded with Mel as primary raw material
Dryingaid, is prepared through ultrasonic dissolution, colloid mill, high pressure homogenize and drying process with atomizing, is prepared using the preparation method
Mel powder recovery rate up to more than 95%, effect is high.
In a preferred embodiment, at least 5 × 10 are contained in every gram of probiotic composition dry weight-3- 0.5g Mel powder.Tool
Body, containing at least 5mg Mel powder, preferably at least 10mg Mel powder, more preferably 25mg in every gram of probiotic composition dry weight
Mel powder.Preferably, containing less than 0.5g Mel powder, preferably more than 0.4g Mel in every gram of probiotic composition dry weight
Powder, more preferably no more than 0.3g Mel powder, most preferably not more than 0.2g Mel powder.
In an alternative embodiment, the Mel powder is by Mel, maltodextrin, beta-schardinger dextrin -5-7 in mass ratio:2-4:
0.5-1.5 is uniformly mixed to get, and wherein, the particle diameter of the Mel powder is 20-40 mesh.Specifically, the preparation method of Mel powder can
For：Said components are uniformly mixed in mass ratio, 50 DEG C of deionized water is added, is fully dissolved so that the solid content of mixed liquor
Content is 32-35%, and mixed liquor is carried out under power 200-400W, frequency 30-40KHz, room temperature condition ultrasonic Treatment 5-
10mi n, then through colloid mill circular grinding 2-4 time, homogenizing, homogenization pressure 25-30MPa, 50-60 DEG C of homogenizing temperature, homogenizing fluid
In inlet temperature 180-200 DEG C, 70-90 DEG C of leaving air temp is drying to obtain Mel powder to spray-dried machine, and Mel powder particle diameter is 20-
40 mesh.It is understood that for the method for preparing Mel powder is not limited merely to above-mentioned cited, can also be this area
Other rational methods for preparing are suitable to known to technical staff.
Fructus Hordei Germinatus powder
Fructus Hordei Germinatus are obtained for the mature fruit of grass family annual herb plant Fructus Hordei Vulgaris is dried through germination.Used in the present embodiment
Fructus Hordei Germinatus by wheat grain is soaked in water after, keep suitable epidemic disaster, whne plumelet length to about when, be drying to obtain.Fructus Hordei Germinatus sweet in the mouth,
Mild-natured, returns spleen, stomach, Liver Channel,《Haigoushen》(Fructus Hordei Germinatus) digestion dyspepsia is pointed out, cold air is broken, is removed trusted subordinate's distension；Modern medicine study is sent out
It is now able to adjust spleen and stomach function, prevents food stagnation indigestion, so as to keep the unobstructed of digestive system.Therefore, Fructus Hordei Germinatus can improve stomach
Disappearance ability, mitigates the burden of intestinal preventing constipation.It should be noted that moved because of sitting less in treatment, the work of high intensity
The body negative and positive of qi and blood loss for causing, large intestine transmission are powerless, in the case of ultimately resulting in constipation, should also be in dredging digestive system
Benefiting qi and nourishing blood, improves the anti-fatigue ability of body simultaneously.
In a preferred embodiment, at least 5 × 10 are contained in every gram of probiotic composition dry weight-3- 0.5g Fructus Hordei Germinatus powder.
Specifically, containing at least 5mg Fructus Hordei Germinatus powder, preferably at least 10mg Fructus Hordei Germinatus powder in every gram of probiotic composition dry weight, more excellent
Choosing at least 25mg Fructus Hordei Germinatus.Preferably, containing 0.5g Fructus Hordei Germinatus powder is less than in every gram of probiotic composition dry weight, preferably not
More than 0.4g Fructus Hordei Germinatus powder, more preferably no more than 0.3g Fructus Hordei Germinatus powder, most preferably not more than 0.2g Fructus Hordei Germinatus powder.
Fructus Lycii powder
《Compendium of Materia Medica》Record " Fructus Lycii is sweet flat and moisten, property is nourished ... energy the kidney invigorating, lung moistening, spermatogenesis, QI invigorating, this is flat
The medicine of benefit." with fine jade treasure Ganoderma, Changbai Mountain Radix Ginseng, Donga Colla Corii Asini the referred to as treasured of Chinese medicine four, can gentle benefit fill blood.Modern
Medical research shows that Fructus Lycii has the multiple efficacies such as the kidney invigorating, liver protection, enhance immunity, resisting fatigue, is the good merchantable brand of nourishing and body-building.
Additionally, Fructus Lycii can increase lactic acid bacteria, Lactobacillus plantarum, bacillus acidophilus, bifidobacteria infantiies, streptococcus thermophiluss, Bao Jiali
The quantity of multiple probiotic bacterias such as sub- lactobacilluss, bifidobacterium adolescentiss, has advantageous effect to the growth and breeding of probiotic bacteria, indirectly
There is regulating intestinal canal function.
In a preferred embodiment, at least 5 × 10 are contained in every gram of probiotic composition dry weight-3- 0.5g Fructus Lycii powder.Tool
Body, containing at least 5mg Fructus Lycii powder in every gram of probiotic composition dry weight, preferably at least 10mg Fructus Lycii powder, more preferably at least
25mg Fructus Lycii powder.Preferably, containing less than 0.5g Fructus Lycii powder, preferably more than 0.4g in every gram of probiotic composition dry weight
Fructus Lycii powder, more preferably no more than 0.3g Fructus Lycii powder, most preferably not more than 0.2g Fructus Lycii powder.
The embodiment of another aspect of the present invention provides a kind of probiotic composition as described in above-mentioned any one embodiment
Application in the compositionss for being used for preventing experimenter's constipation are prepared.The probiotic composition provided by the present embodiment is due to having
Effectiveness intestine moistening of promoting the production of body fluid, mends QI and blood regulating, heat clearing and tranquillizing in while strengthening intestinal maneuverability, maintaining intestinal environment stable,
So as to improve the regulating power of body itself, the purpose of Constipation is finally reached, therefore can play effect of Constipation.
In an alternative embodiment, the probiotic composition is in liquid form or solid-state form gives.Due to this enforcement
In the formula that provided of example, each component has auxiliary or a synergism, but mutually not antagonism, therefore can for example according to known
Conventional method, the compositionss of the present invention is added or without the raw material allowed in health food, is configured to improving constipation
The liquid preparation of function, oral liquid etc.；Or, by the present invention compositionss by appropriate drying meanss, interpolation or without
The raw material of permission, is configured to the solid preparation for improving purgative function, such as granule etc..
No matter it should be noted which kind of dosage form above-mentioned be prepared into, giving food, health product or the medicine of experimenter daily
In thing, probiotic bacteria gives dosage daily for 102-1012Cfu, preferably 105-1011Cfu, more preferably 107-5×1010cfu；Inulin is every
Dosage is given day for 0.1-12g, preferably 0.2-5g, more preferably 0.5-3g；Mel powder gives dosage daily for 0.1-10g, preferably
0.2-5g, more preferably 0.5-3g；Fructus Hordei Germinatus powder gives dosage daily for 0.1-10g, preferably 0.2-5g, more preferably 0.5-3g；Chinese holly
Qi powder gives dosage daily for 0.1-10g, preferably 0.2-5g, more preferably 0.5-3g.
In order to become apparent from introducing in detail probiotic composition that the embodiment of the present invention provided and its in Constipation
Application, be described below in conjunction with specific embodiment.
Embodiment 1
A kind of solid tablet, every gram of solid tablet dry weight include：
Probiotic bacteria 1 × 109Cfu, inulin 1g, Mel powder 0.1g, Fructus Hordei Germinatus powder 0.2g, Fructus Lycii powder 0.1g.Every solid piece
Agent is 1g, it is proposed that daily three times, 4 tablets once.
Select 50 to be also easy to produce constipation in the motionless working environment of sitting and have the civilian personnel of above constipation history twice,
The daily probiotic group thing under the health of not constipation, according to normal operating conditions participation work.After three weeks, have 37
Name personnel are fed back when there is no constipation and body reply hard work in the daily diet that constipation can occur and activity situation
Mental status make moderate progress, and having 9 personnel's feedbacks to produce the cycle stretch-out of constipation, body anti-fatigue ability increases, and has 3 personnel
Feedback does not have change, has 1 personnel midway to abandon eating.It follows that effective percentage reaches 92%, illustrate provided by the present invention
Product can prevent high pressure, fast pace, the constipation phenomenon of erratic Working Life generation and its complication, take group and compare
The frequency occurred in the constipation that does not take, dyspeptic phenomenon is low, and body anti-fatigue ability is improved, QI and blood and benefit.
Embodiment 2
A kind of solid beverage, includes per g：
Probiotic bacteria 1 × 107Cfu, inulin 0.5g, Mel 0.25g, Fructus Hordei Germinatus 0.25g, Fructus Lycii 0.25g.Suggestion is daily
15-18g.
Embodiment 3
A kind of oral liquid, includes per 100mL：
Probiotic bacteria 1 × 105Cfu, inulin 0.005g, Mel 0.005g, Fructus Hordei Germinatus 0.005g, Fructus Lycii 0.005g.Suggestion is every
Day takes 250-270mL.
Claims (10)
1. a kind of probiotic composition, it is characterised in that including the raw material of following weight portion：Probiotic bacteria 2-6 parts, inulin 4-6 parts,
Mel powder 1-3 parts, Fructus Hordei Germinatus powder 1-3 parts, Fructus Lycii powder 1-3 part.
2. probiotic composition according to claim 1, it is characterised in that the probiotic bacteria selected from lactobacillus rhamnosuss,
Bacillus acidophilus, lactobacillus casei, Lactobacillus crispatus, Deshi Lactobacilluss, Lactobacillus bulgaricus, lactobacillus helveticuss, fermentation milk
Bacillus, Lactobacillus gasseri, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus reuteri, lactobacillus rhamnosuss,
Lactobacillus salivarius, bifidobacterium adolescentiss, animal bifidobacteria, bifidobacterium bifidum, bifidobacterium breve, bifidobacteria infantiies, length
Bacillus bifiduss, streptococcus thermophiluss, Bacillus coagulans, Haematocoocus Pluvialls, lactococcus lactis, Leuconostoc mesenteroides and Marx gram
One or more in the dimension yeast of Shandong.
3. probiotic composition according to claim 1, it is characterised in that contain in every gram of probiotic composition dry weight
102To 1012The probiotic bacteria of cfu, preferably 104To 1011, more preferably 105To 1010, most preferably 105To 5 × 109.
4. probiotic composition according to claim 1, it is characterised in that contain in every gram of probiotic composition dry weight
At least 5 × 10-3- 1g inulin.
5. probiotic composition according to claim 1, it is characterised in that contain in every gram of probiotic composition dry weight
At least 5 × 10-3- 0.5g Mel powder.
6. the probiotic composition according to any one of claim 1-5, it is characterised in that the Mel powder is by Mel, wheat
Bud dextrin, beta-schardinger dextrin -5-7 in mass ratio:2-4:0.5-1.5 is uniformly mixed to get, and wherein, the particle diameter of the Mel powder is 20-
40 mesh.
7. probiotic composition according to claim 1, it is characterised in that contain in every gram of probiotic composition dry weight
At least 5 × 10-3- 0.5g Fructus Hordei Germinatus powder.
8. probiotic composition according to claim 1, it is characterised in that contain in every gram of probiotic composition dry weight
At least 5 × 10-3- 0.5g Fructus Lycii powder.
9. a kind of probiotic composition as described in any one of claim 1-8 is used for the combination for preventing experimenter's constipation in preparation
Application in thing.
10. application according to claim 9, it is characterised in that the probiotic composition is in liquid form or solid-state shape
Formula gives.
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| CN107095308A (en) * | 2017-07-03 | 2017-08-29 | 广东格物生物科技有限公司 | A kind of probiotics preparation and its application |
| CN107411094A (en) * | 2017-05-12 | 2017-12-01 | 广州赛莱拉干细胞科技股份有限公司 | A kind of composition for improving enteric microorganism and the soft sweets for improving enteric microorganism |
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| CN113812622A (en) * | 2021-09-10 | 2021-12-21 | 盛尚杞美(宁夏)生物科技开发有限公司 | Chinese wolfberry tablet for improving human intestinal flora and preparation method thereof |
| CN114806930A (en) * | 2022-03-31 | 2022-07-29 | 青岛东海药业有限公司 | Probiotic composition and application thereof |
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