CN107019781A - 一种治疗带状疱疹的药物及其制备方法 - Google Patents

一种治疗带状疱疹的药物及其制备方法 Download PDF

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CN107019781A
CN107019781A CN201710298611.2A CN201710298611A CN107019781A CN 107019781 A CN107019781 A CN 107019781A CN 201710298611 A CN201710298611 A CN 201710298611A CN 107019781 A CN107019781 A CN 107019781A
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徐士魁
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徐士魁
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Abstract

本发明公开了一种治疗带状疱疹的药物及其制备方法,其主要是由白茅根、紫花地丁、薏苡仁、金银花、连翘、大青叶、紫草、柴胡、龙胆、延胡索、败酱、虎杖、当归、郁金、牡丹皮、板蓝根、甘草、黄芩、川楝子、玉米须、薄荷、陈皮、僵蚕按一定重量配比制备而成,本发明药物具有清热解毒,泻实火,除湿热,健脾,活血散瘀的功能,用于治疗带状疱疹见效快、疗效好,不复发。

Description

一种治疗带状疱疹的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗带状疱疹的药物及其制备方法,属中药领域。
背景技术
[0002] 带状疱疹是由水痘-带状疱疹病毒引起的急性感染性皮肤病。对此病毒无免疫力 的儿童被感染后,发生水痘。部分患者被感染后成为带病毒者而不发生症状。由于病毒具有 亲神经性,感染后可长期潜伏于脊髓神经后根神经节的神经元内,当抵抗力低下或劳累、感 染、感冒时,病毒可再次生长繁殖,并沿神经纤维移至皮肤,使受侵犯的神经和皮肤产生强 烈的炎症。中医则认为带状疱疹与肝经郁热,脾虚湿蕴,气滞血瘀有关。由于西药治疗副作 用大,因此人们对有效治疗带状疱疹的中药药物存在极大的需求,至今为止,还没有发现关 于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗带状 疱疹的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗带状疱疹的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择白茅根、紫花地丁、薏苡仁、金银花、连翘、大青叶、紫草、柴胡、 龙胆、延胡索、败酱、虎杖、当归、郁金、牡丹皮、板蓝根、甘草、黄芩、川楝子、玉米须、薄荷、陈 皮、僵蚕、荆芥、马齿苋、淡竹叶进行组合制备的,将这些药物组合使得各药物功效产生协同 作用,从而能够有效治疗带状疱疹。其中选用白茅根是因为其性味甘、寒,入肺、胃、小肠经, 有凉血,止血,清热,利尿的功能,治热病烦渴,吐血,衄血,肺热喘急,胃热哕逆,淋病,小便 不利,水肿,黄疸。选用紫花地丁是因为其性味苦、辛、寒,归心、肝经,有清热解毒,凉血消肿 的功能,治疔疮肿毒,痈疽发背,丹毒,毒蛇咬伤。选用薏苡仁是因为其性味甘淡,凉,入脾、 肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气, 肺痿,肺痈,肠痈,淋浊,白带。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的 功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用连翘是因为其性味苦,凉,入心、 肝、胆经,有清热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。 选用大青叶是因为其性味苦,寒,入肝、心、胃经,有清热,解毒,凉血,止血的功能,治温病热 盛烦渴,流行性感冒,急性传染性肝炎,菌痢,急性胃肠炎,急性肺炎,丹毒,吐血,衄血,黄 疸,痢疾,喉痹,口疮,痈疽肿毒。选用紫草是因为其性味苦苦,寒,入心包络、肝经,有凉血, 活血,清热解毒的功能,治温热斑疹,湿热黄疸,紫癜,吐、衄、尿血,淋浊,血痢,热结便秘,烧 伤,湿疹,丹毒,痈疡。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的 功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选 用龙胆是因为其性味苦,寒,入肝、胆经,有泻肝实火,除下焦湿热的功能,治肝经热盛,惊癎 狂躁,乙型脑炎,头痛,目赤,咽痛,黄疸,热痢,痈肿疮疡,阴囊肿痛,阴部湿痒。选用延胡索 是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经 不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用败酱是因为其性味苦,平,入肝、胃、 大肠经,有清热解毒,排脓破瘀的功能,治肠痈,下痢,赤白带下,产后瘀滞腹痛,目赤肿痛, 痈肿疥癣。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿筋骨疼 痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶 疮癣疾。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠 的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后 重,痈疽疮疡,金疮,跌扑损伤。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解 随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒 经,黄疸。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功 能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用板蓝根是 因为其性味苦,寒,入肝、胃血分,有清热,解毒,凉血的功能,治流感,流脑,乙脑,肺炎,丹 毒,热毒发斑,神昏吐紐,咽肿,痒腮,火眼,疮疹。选用甘草是因为其性味甘平,入脾、胃、肺 经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热, 肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用黄 芩是因为其性味苦,寒,入心、肺、胆、大肠经,有泻实火,除湿热,止血,安胎的功能,治壮热 烦渴,肺热咳嗽,湿热泻痢,黄疸,热淋,吐、衄、崩、漏,目赤肿痛,胎动不安,痈肿疔疮。选用 川楝子是因为其性味苦,寒,有毒,入肝、胃、小肠经,有降湿热,清肝火,止痛,杀虫的功能, 治热厥心痛,胁痛,疝痛,虫积腹痛。选用玉米须是因为其性味甘,平,有利尿,泄热,平肝,利 胆的功能,治肾炎水肿,脚气,黄疸肝炎,高血压,胆囊炎,胆结石,糖尿病,吐血衄血,鼻渊, 乳痈。选用薄荷是因为其性味辛,凉,入肺、肝经,有疏风,散热,辟秽,解毒的功能,治外感风 热,头痛,目赤,咽喉肿痛,食滞气胀,□疮,牙痛,疮疥,瘾疹。选用陈皮是因为其性味苦、辛, 温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用僵蚕 是因为其性味辛、咸,平,归肝,肺经。祛风解痉,化痰散结。用于中风口眼歪斜,惊痫抽搐,头 赐,喉痹,瘰疠结核,风疹丹毒。选用荆芥是因为其性味辛,温,入肺、肝经,有发表,祛风,理 血的功能,炒炭止血,治感冒发热,头痛,咽喉肿痛,中风口噤,吐血,衄血,便血,崩漏,产后 血晕,痈肿,疮疥,瘰疬。选用马齿苋是因为其性味酸,寒,入大肠、肝、脾经,有清热解毒,散 血消肿的功能,治热痢脓血,热淋,血淋,带下,痈肿恶疮,丹毒,瘰疬。选用淡竹叶是因为其 性味甘淡,寒,入心肾二经,有清心火,除烦热,利小便的功能,治热病口渴,心烦,小便赤涩, 淋浊,口糜舌疮,牙龈肿痛。
具体实施方式 [0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重 量范围内都具有较好的疗效: 白茅根10-20克,紫花地丁15-25克,薏苡仁10-20克,金银花10-20克,连翘10-15克,大 青叶10-20克,紫草5-15克,柴胡5-15克,龙胆5-10克,延胡索10-15克,败酱5-15克,虎杖15-20克,当归15-20克,郁金10-15克,牡丹皮10-20克,板蓝根10-15克,甘草5-15克,黄芩10-15 克,川楝子10-15克,玉米须10-20克,薄荷5-15克,陈皮10-15克,僵蚕15-20克,荆芥10-15 克,马齿苋5-15克,淡竹叶10-15克。
[0008] 优选为: 白茅根15克,紫花地丁20克,薏苡仁15克,金银花15克,连翘12克,大青叶15克,紫草10 克,柴胡10克,龙胆8克,延胡索12克,败酱10克,虎杖18克,当归18克,郁金12克,牡丹皮15 克,板蓝根12克,甘草10克,黄芩12克,川楝子12克,玉米须15克,薄荷10克,陈皮12克,僵蚕 18克,荆芥12克,马齿苋10克,淡竹叶12克。
[0009] 本发明药物的制备方法如下 一、备料 1、 白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; 2、 紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥; 3、 意该仁:取原药材,除去残留皮壳、杂质; 4、 金银花:筛去泥沙,拣净杂质; 5、 连翘:拣净杂质,搓开,除去枝梗; 6、 大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干; 7、 紫草:洗净,润透,切片,晒干; 8、 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干; 9、 龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干; 10、 延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎; 11、 败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥; 12、 虎杖:米得后,切段,晒干; 13、 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; 14、 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; 15、 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; 16、 板蓝根:拣净杂质,洗净,润透,切片,晒干; 17、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; 18、 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,润透后切片晒干,注 意避免曝晒过度发红; 19、 川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; 20、 玉米须:取原药材,除去杂质,筛去灰肩; 21、 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒 干,再与叶和匀; 22、 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; 23、 僵蚕:取原药材,除去残丝,杂质; 24、 荆芥:拣净杂质,用水略泡,捞出切段,晒干; 25、 马齿苋:拣净杂质,除去残根,以水稍润,切段晒干; 26、 淡竹叶:拣去杂质及根,切段,晒干。
[0010] 二、制备 1、将所述重量的白茅根、紫花地丁、薏苡仁、金银花、连翘、大青叶、紫草、柴胡、龙胆、延 胡索、败酱、虎杖、当归、郁金、牡丹皮、板蓝根、甘草、黄芩、川楝子、玉米须、薄荷、陈皮、僵 蚕、荆芥、马齿苋、淡竹叶放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸 腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内; 2、 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; 3、 将两次煎煮液混合搅拌均匀,分为3剂服用。
[0011] 组方中紫花地丁有清热解毒,凉血消肿的功能为君药;薏苡仁健脾,补肺,清热,利 湿;延胡索有活血,散瘀,理气,止痛的功能,二者为臣药,三味药共同发挥清热解毒,清热利 湿,健脾,活血散瘀,凉血消肿的作用,治疗带状疱疹效力全面,且以清热解毒,清热利湿,健 脾,活血散瘀为主可治本,荆芥有发表,祛风,理血功能为佐药,黄芩有泻实火,除湿热的功 能为使药,与下余诸药是治标。
[0012] 本发明药物具有清热解毒,泻实火,除湿热,健脾,活血散瘀的功能,用于治疗带状 疱疹,疗程短、见效快、治愈后不复发。
[0013] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0015] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治带状疱疹门诊患者共37例。
[0016] 2、诊断标准 典型症状为轻度乏力,低热,纳差,神经痛,患处常首先出现潮红斑,很快出现粟粒至黄 豆大小的丘疹,簇状分布而不融合,继之迅速变为水疱。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、中、晚各服1次,7天为一个疗程,连 续服用3个疗程。
[0018] 4、疗效评定标准 显效:带状疱疹症状消失,体质恢复正常,痊愈; 好转:患者轻度乏力,低热,纳差,神经痛的现象减轻,带状疱疹症状明显好转,体质逐 步恢复; 无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN107019781AD00081
在上述治疗中,用本发明药物治疗带状疱疹患者37例,结果显效30例,显效率为 81.09%,好转5例,好转率为13.51%,无效2例,总有效率为94.6%。

Claims (3)

1. 一种治疗带状疱瘆的药物,其特征在于:它是由下列重量范围内的原料药制成: 白茅根10-20克,紫花地丁15-25克,薏苡仁10-20克,金银花10-20克,连翘10-15克,大 青叶10-20克,紫草5-15克,柴胡5-15克,龙胆5-10克,延胡索10-15克,败酱5-15克,虎杖15-20克,当归15-20克,郁金10-15克,牡丹皮10-20克,板蓝根10-15克,甘草5-15克,黄芩10-15 克,川楝子10-15克,玉米须10-20克,薄荷5-15克,陈皮10-15克,僵蚕15-20克,荆芥10-15 克,马齿苋5-15克,淡竹叶10-15克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 白茅根15克,紫花地丁20克,薏苡仁15克,金银花15克,连翘12克,大青叶15克,紫草10 克,柴胡10克,龙胆8克,延胡索12克,败酱10克,虎杖18克,当归18克,郁金12克,牡丹皮15 克,板蓝根12克,甘草10克,黄芩12克,川楝子12克,玉米须15克,薄荷10克,陈皮12克,僵蚕 18克,荆芥12克,马齿苋10克,淡竹叶12克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; (2) 紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥; (3) 意该仁:取原药材,除去残留皮壳、杂质; (4) 金银花:筛去泥沙,拣净杂质; (5) 连翘:拣净杂质,搓开,除去枝梗; (6) 大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干; (7) 紫草:洗净,润透,切片,晒干; ⑻柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干; (9) 龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干; (10) 延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎; (11) 败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥; (12) 虎杖:采得后,切段,晒干; (13) 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; (14) 郁金:用水浸泡,洗净,携出晒晾,润透,切片,晒干; (15) 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; (16) 板蓝根:拣净杂质,洗净,润透,切片,晒干; (17) 甘草:拣去杂质,洗净,用水浸泡至Λ成透时,捞出,润透,切片,凉干; (18) 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,润透后切片晒干,注 意避免曝晒过度发红; (19) 川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; (20) 玉米须:取原药材,除去杂质,筛去灰肩; (21) 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒 干,再与叶和匀; (22) 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; (23) 僵蚕:取原药材,除去残丝,杂质; (24) 荆芥:拣净杂质,用水略泡,捞出切段,晒干; (25) 马齿苋:拣净杂质,除去残根,以水稍润,切段晒干; (26) 淡竹叶:拣去杂质及根,切段,晒干; (二)制备 (1) 将所述重量的白茅根、紫花地丁、薏苡仁、金银花、连翘、大青叶、紫草、柴胡、龙胆、 延胡索、败酱、虎杖、当归、郁金、牡丹皮、板蓝根、甘草、黄芩、川楝子、玉米须、薄荷、陈皮、僵 蚕、荆芥、马齿苋、淡竹叶放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用 文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀,分为3剂服用。
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