CN1068305C - 制备其对映体纯度大于90％的s(－)2－(4－异丁基苯基)丙酸钠的方法 - Google Patents

制备其对映体纯度大于90％的s(－)2－(4－异丁基苯基)丙酸钠的方法 Download PDF

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Publication number
CN1068305C
CN1068305C CN92104550A CN92104550A CN1068305C CN 1068305 C CN1068305 C CN 1068305C CN 92104550 A CN92104550 A CN 92104550A CN 92104550 A CN92104550 A CN 92104550A CN 1068305 C CN1068305 C CN 1068305C
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CN
China
Prior art keywords
sodium
isobutylphenyl
propionate
water
isobutyl phenenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN92104550A
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English (en)
Chinese (zh)
Other versions
CN1068734A (zh
Inventor
B·J·阿米塔奇
P·F·科
J·F·兰帕德
A·史密夫
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Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26298899&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1068305(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919110342A external-priority patent/GB9110342D0/en
Priority claimed from GB919112058A external-priority patent/GB9112058D0/en
Application filed by Boots Co PLC filed Critical Boots Co PLC
Publication of CN1068734A publication Critical patent/CN1068734A/zh
Application granted granted Critical
Publication of CN1068305C publication Critical patent/CN1068305C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN92104550A 1991-05-13 1992-05-12 制备其对映体纯度大于90％的s(－)2－(4－异丁基苯基)丙酸钠的方法 Expired - Fee Related CN1068305C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919110342A GB9110342D0 (en) 1991-05-13 1991-05-13 Therapeutic agent
GB9110342.4 1991-05-13
GB919112058A GB9112058D0 (en) 1991-06-05 1991-06-05 Therapeutic agent
GB9112058.4 1991-06-05

Publications (2)

Publication Number Publication Date
CN1068734A CN1068734A (zh) 1993-02-10
CN1068305C true CN1068305C (zh) 2001-07-11

Family

ID=26298899

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92104550A Expired - Fee Related CN1068305C (zh) 1991-05-13 1992-05-12 制备其对映体纯度大于90％的s(－)2－(4－异丁基苯基)丙酸钠的方法

Country Status (32)

Country Link
US (3) US6525214B1 (https=)
EP (1) EP0584108B1 (https=)
JP (1) JP3326174B2 (https=)
KR (1) KR100198044B1 (https=)
CN (1) CN1068305C (https=)
AT (1) ATE195417T1 (https=)
AU (1) AU658415B2 (https=)
BG (1) BG61676B1 (https=)
CA (1) CA2102530C (https=)
CZ (1) CZ281717B6 (https=)
DE (1) DE69231359T2 (https=)
DK (1) DK0584108T3 (https=)
EG (1) EG20309A (https=)
ES (1) ES2148175T3 (https=)
FI (1) FI109994B (https=)
GE (1) GEP20002013B (https=)
GR (1) GR3034780T3 (https=)
HU (1) HU219242B (https=)
IE (1) IE921393A1 (https=)
IL (1) IL101818A (https=)
MX (1) MX9202215A (https=)
MY (1) MY110267A (https=)
NO (2) NO304678B1 (https=)
NZ (1) NZ242640A (https=)
PT (1) PT100476B (https=)
RO (1) RO118371B1 (https=)
RU (1) RU2145219C1 (https=)
SK (1) SK279279B6 (https=)
TW (1) TW304940B (https=)
UA (1) UA34430C2 (https=)
WO (1) WO1992020334A1 (https=)
YU (1) YU48928B (https=)

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Also Published As

Publication number Publication date
JPH06507159A (ja) 1994-08-11
CZ240593A3 (en) 1994-03-16
YU50292A (sh) 1995-03-27
TW304940B (https=) 1997-05-11
AU1671192A (en) 1992-12-30
WO1992020334A1 (en) 1992-11-26
BG98214A (bg) 1994-07-29
DK0584108T3 (da) 2000-10-09
RO118371B1 (ro) 2003-05-30
CA2102530C (en) 2003-07-29
US6525214B1 (en) 2003-02-25
IL101818A0 (en) 1992-12-30
US5696165A (en) 1997-12-09
NO305696B1 (no) 1999-07-12
PT100476B (pt) 1999-09-30
FI934964A0 (fi) 1993-11-10
IL101818A (en) 1999-08-17
DE69231359D1 (de) 2000-09-21
SK125993A3 (en) 1994-04-06
EG20309A (en) 1998-10-31
JP3326174B2 (ja) 2002-09-17
BG61676B1 (bg) 1998-03-31
GEP20002013B (en) 2000-04-10
MX9202215A (es) 1992-11-01
CN1068734A (zh) 1993-02-10
PT100476A (pt) 1993-08-31
NO982500D0 (no) 1998-06-02
HU9303220D0 (en) 1994-03-28
KR100198044B1 (ko) 1999-06-15
RU2145219C1 (ru) 2000-02-10
US6242000B1 (en) 2001-06-05
MY110267A (en) 1998-03-31
NZ242640A (en) 1993-11-25
YU48928B (sh) 2002-12-10
NO934102D0 (no) 1993-11-12
UA34430C2 (uk) 2001-03-15
HU219242B (en) 2001-03-28
US5696165B1 (en) 2000-12-05
ES2148175T3 (es) 2000-10-16
AU658415B2 (en) 1995-04-13
SK279279B6 (sk) 1998-09-09
CZ281717B6 (cs) 1996-12-11
EP0584108B1 (en) 2000-08-16
FI109994B (fi) 2002-11-15
IE921393A1 (en) 1992-11-18
HUT67034A (en) 1995-01-30
NO304678B1 (no) 1999-02-01
ATE195417T1 (de) 2000-09-15
CA2102530A1 (en) 1992-11-14
NO934102L (no) 1993-11-12
DE69231359T2 (de) 2001-02-08
EP0584108A1 (en) 1994-03-02
GR3034780T3 (en) 2001-02-28
FI934964L (fi) 1993-11-10
NO982500L (no) 1993-11-12

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