YU48928B - Postupak dobijanja ibuprofenskog derivata - Google Patents

Postupak dobijanja ibuprofenskog derivata

Info

Publication number
YU48928B
YU48928B YU50292A YU50292A YU48928B YU 48928 B YU48928 B YU 48928B YU 50292 A YU50292 A YU 50292A YU 50292 A YU50292 A YU 50292A YU 48928 B YU48928 B YU 48928B
Authority
YU
Yugoslavia
Prior art keywords
solid
enantiomer
propionic acid
sodium salt
procedure
Prior art date
Application number
YU50292A
Other languages
English (en)
Serbo-Croatian (sh)
Other versions
YU50292A (sh
Inventor
Bernard John Armitage
Paul Frederick Coe
John Francis Lampard
Alan Smith
Original Assignee
The Boots Company Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26298899&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU48928(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919110342A external-priority patent/GB9110342D0/en
Priority claimed from GB919112058A external-priority patent/GB9112058D0/en
Application filed by The Boots Company Plc. filed Critical The Boots Company Plc.
Publication of YU50292A publication Critical patent/YU50292A/sh
Publication of YU48928B publication Critical patent/YU48928B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
YU50292A 1991-05-13 1992-05-13 Postupak dobijanja ibuprofenskog derivata YU48928B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919110342A GB9110342D0 (en) 1991-05-13 1991-05-13 Therapeutic agent
GB919112058A GB9112058D0 (en) 1991-06-05 1991-06-05 Therapeutic agent

Publications (2)

Publication Number Publication Date
YU50292A YU50292A (sh) 1995-03-27
YU48928B true YU48928B (sh) 2002-12-10

Family

ID=26298899

Family Applications (1)

Application Number Title Priority Date Filing Date
YU50292A YU48928B (sh) 1991-05-13 1992-05-13 Postupak dobijanja ibuprofenskog derivata

Country Status (32)

Country Link
US (3) US6525214B1 (https=)
EP (1) EP0584108B1 (https=)
JP (1) JP3326174B2 (https=)
KR (1) KR100198044B1 (https=)
CN (1) CN1068305C (https=)
AT (1) ATE195417T1 (https=)
AU (1) AU658415B2 (https=)
BG (1) BG61676B1 (https=)
CA (1) CA2102530C (https=)
CZ (1) CZ281717B6 (https=)
DE (1) DE69231359T2 (https=)
DK (1) DK0584108T3 (https=)
EG (1) EG20309A (https=)
ES (1) ES2148175T3 (https=)
FI (1) FI109994B (https=)
GE (1) GEP20002013B (https=)
GR (1) GR3034780T3 (https=)
HU (1) HU219242B (https=)
IE (1) IE921393A1 (https=)
IL (1) IL101818A (https=)
MX (1) MX9202215A (https=)
MY (1) MY110267A (https=)
NO (2) NO304678B1 (https=)
NZ (1) NZ242640A (https=)
PT (1) PT100476B (https=)
RO (1) RO118371B1 (https=)
RU (1) RU2145219C1 (https=)
SK (1) SK279279B6 (https=)
TW (1) TW304940B (https=)
UA (1) UA34430C2 (https=)
WO (1) WO1992020334A1 (https=)
YU (1) YU48928B (https=)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA34430C2 (uk) * 1991-05-13 2001-03-15 Дзе Бутс Компані Плс S(-)-2-(4-ізобутилфеніл)пропіонат натрію дигідрат, придатний для лікування запалення, болю і гіпертермії, фармацевтична композиція на його основі та спосіб одержання s(-)-2-(4-ізобутилфеніл)пропіонату натрію
US5260482A (en) † 1992-10-14 1993-11-09 Ethyl Corporation Enantiomeric resolution
US5248813A (en) * 1992-10-14 1993-09-28 Ethyl Corporation Enantiomeric resolution
GB9224021D0 (en) * 1992-11-16 1993-01-06 Boots Co Plc Effervescent compositions
ES2134796T3 (es) * 1992-12-01 1999-10-16 Spirig Ag Pharmazeutische Prap Composiciones farmaceuticas que contienen s(+)-ibuprofeno.
CA2150355C (en) * 1992-12-02 2008-03-11 Robert Hardy Process of resolving phenylpropionic acids using alpha-methylbenzylamine
SI9300470A (en) * 1993-09-10 1995-04-30 Lek Tovarna Farmacevtskih Inclusion complexes of optically active and racemic ibuproxan with cyclodextrin derivates,process for their preparation,pharmaceutical preparations comprising the same and their use
EP0667149A1 (en) * 1994-02-14 1995-08-16 E-PHARMA TRENTO S.p.A. Ibuprofen based effervescent composition
IT1270239B (it) * 1994-06-17 1997-04-29 Zambon Spa Composizione farmaceutica solida contenente acido (s)-2-(4- isobutilfenil) propionico come principio attivo
TW442287B (en) * 1995-06-13 2001-06-23 American Home Produits Corp Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac)
GB9603699D0 (en) * 1996-02-21 1996-04-17 Boots Co Plc Therapeutic composition
US5891476A (en) * 1997-12-22 1999-04-06 Reo; Joe P. Tastemasked pharmaceutical system
DE19814256A1 (de) * 1998-03-31 1999-10-07 Asta Medica Ag Feste, schnellzerfallende Cetirizin-Formulierungen
US20050063998A1 (en) * 1999-10-26 2005-03-24 Francois Marc Karel Jozef Oral solution containing galantamine and a sweetening agent
FR2800276B1 (fr) * 1999-10-27 2004-08-20 Palbian Snc Composition et medicament, notamment anti-inflammatoire, constitue de ladite composition
NZ508292A (en) * 1999-11-24 2002-08-28 Mcneil Ppc Inc Treatment of migraine symptoms with ibuprofen and salts thereof
PT1321140E (pt) * 2000-08-25 2005-06-30 Kowa Co Solucoes de ibuprofeno para o enchimento de capsulas e preparacoes de capsula
JP2002069030A (ja) * 2000-08-30 2002-03-08 Kyowa Hakko Kogyo Co Ltd ナトリウム２−｛４−［（２−オキソシクロペンチル）メチル］フェニル｝プロピオネート２水和物の製造法
GB0028575D0 (en) * 2000-11-23 2001-01-10 Elan Corp Plc Oral pharmaceutical compositions containing cyclodextrins
US6440983B1 (en) * 2000-12-21 2002-08-27 Mary Theresa Frank-Kollman Compositions and methods for relieving headache symptoms in aspirin-sensitive headache sufferers
AU2002255190A1 (en) * 2001-04-10 2002-10-28 Fakhreddin Jamali Composition for enhanced absorption of nsaids
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
AU2002341984B2 (en) * 2001-10-04 2008-01-03 Macrochem Corporation Ibuprofen salt emulsifiers and cream formulations containing same
US20030124174A1 (en) * 2001-10-25 2003-07-03 Endo Pharmaceuticals, Inc Method for treating non-neuropathic pain
AU2003280960A1 (en) * 2002-07-15 2004-02-02 Alcon, Inc. Pharmaceutical compositions for otic use
ES2295647T3 (es) * 2002-07-15 2008-04-16 Alcon, Inc. Composiciones de implante farmaceuticas lipofilas, no polimeras, para uso intraocular.
ATE424187T1 (de) * 2002-07-15 2009-03-15 Alcon Inc Bioerodierbare folie zur abgabe eines ophthalmischen arzneimittels
CL2003002653A1 (es) * 2002-12-18 2005-04-22 Wyeth Corp Composicion farmaceutica que comprende (a) un antiinflamatorio no esteroidal (nsaid), preferentemente ibuprofeno, (b) un descongestionante, preferentemente pseudoefedrina y (c) un antihistaminico, preferentemente clorfeniramina; metodo para su prepar
US20040228804A1 (en) * 2003-05-16 2004-11-18 Jones Alonzo H. Nasal administration of xylitol to a non-human mammal
CZ2004262A3 (cs) * 2004-02-20 2005-06-15 I. Q. A., A. S. Stabilní, chuťově přijatelné sirupy obsahující ibuprofen a způsob jejich přípravy
GB2411833A (en) * 2004-03-08 2005-09-14 Skin Salveation Ltd Composition for use in the treatment of dry skin conditions
WO2005121061A1 (en) * 2004-06-07 2005-12-22 Strides Research And Specialty Chemicals Limited Novel process for producing ibuprofen sodium dihydrate
MXPA06014185A (es) * 2004-06-07 2007-04-16 Strides Arcolab Ltd Composicion farmaceutica que contiene una solucion estable y clara de medicamento anti-inflmatorio en capsulas de gelatina blanda, y proceso para producirlo.
JP2008509207A (ja) * 2004-08-12 2008-03-27 レキット ベンキーザー ヘルスケア （ユーケイ） リミテッド 溶融押出しにより作製するパラセタモール、ｎｓａｉｄ及び糖アルコールを含む顆粒
EP1919288A4 (en) * 2005-07-18 2009-12-16 Horizon Therapeutics Inc FAMOTIDINE- AND IBUPROGEN-BASED MEDICAMENTS AND THEIR ADMINISTRATION
US20080020040A1 (en) * 2006-07-18 2008-01-24 Horizon Therapeutics, Inc. Unit dose form for administration of ibuprofen
US8067451B2 (en) * 2006-07-18 2011-11-29 Horizon Pharma Usa, Inc. Methods and medicaments for administration of ibuprofen
US8067033B2 (en) 2007-11-30 2011-11-29 Horizon Pharma Usa, Inc. Stable compositions of famotidine and ibuprofen
CL2007002425A1 (es) * 2006-08-22 2008-06-27 Albermarle Corp Procedimiento de preparacion controlado de sal sodica de ibuprofeno de tamano de particula mediano; y dichas particulas de sal sodica.
FI20080348A0 (fi) * 2008-02-15 2008-05-09 Atacama Labs Oy Uudenlainen farmaseuttinen formulaatio
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
SG185257A1 (en) * 2007-10-10 2012-11-29 Avantor Performance Mat Inc Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof
EP2323976A4 (en) * 2008-08-14 2014-07-02 Shasun Chemicals And Drugs Ltd ARYLALKYLCARBOXYLIC ACID SALTS, PROCESS FOR PREPARATION THEREOF AND GALENIC FORMS
CA2726726A1 (en) 2008-09-10 2010-03-18 Thrubit B.V. Ibuprofen for topical administration
US9566256B2 (en) 2008-09-22 2017-02-14 Biochemics, Inc. Transdermal drug delivery using an osmolyte and vasoactive agent
JP5598330B2 (ja) * 2008-10-29 2014-10-01 三菱瓦斯化学株式会社 光学活性有機カルボン酸の製造方法
TWI504393B (zh) * 2009-06-22 2015-10-21 惠氏有限責任公司 製備包含異丁苯丙酸鈉之醫藥組合物之方法
AU2014200704C1 (en) * 2009-06-22 2018-12-06 Pf Consumer Healthcare 1 Llc Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen
AU2015264861C1 (en) * 2009-06-22 2017-11-16 Pf Consumer Healthcare 1 Llc Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen
ES2541483T3 (es) * 2009-12-16 2015-07-21 Shasun Pharmaceuticals Limited Composición de hidrogel transdérmico de dexibuprofeno
CN102557918B (zh) * 2011-11-28 2013-08-21 海南永田药物研究院有限公司 一种布洛芬钠化合物及其制法
WO2013154511A1 (en) * 2012-04-13 2013-10-17 Mahmut Bilgic Film tablet formulations comprising dexibuprofen
FR2997856B1 (fr) * 2012-11-14 2015-04-24 Pf Medicament Pastille medicamenteuse a base d'ibuprofene sodique dihydrate
CN102992997A (zh) * 2012-11-20 2013-03-27 北京阜康仁生物制药科技有限公司 右布洛芬的新药用盐
CN104744236A (zh) * 2013-12-26 2015-07-01 鲁南贝特制药有限公司 一种右旋布洛芬的精制方法
EP2965746B1 (en) 2014-07-10 2019-03-13 Santa Farma Ilaç Sanayi A.S. An oral pharmaceutical composition comprising ibuprofen, ibuprofen sodium dihydrate, pseudoephedrine hydrochloride and chlorpheniramine maleate
US11007161B1 (en) 2014-12-31 2021-05-18 Eric Morrison Ibuprofen nanoparticle carriers encapsulated with hermatic surfactant films
US10561627B2 (en) 2014-12-31 2020-02-18 Eric Morrison Ibuprofen nanoparticle carriers encapsulated with hermetic surfactant films
US10596117B1 (en) 2014-12-31 2020-03-24 Eric Morrison Lipoleosomes as carriers for aromatic amide anesthetic compounds

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
JPS5826744B2 (ja) 1975-12-24 1983-06-04 ヒサミツセイヤク カブシキガイシヤ シンキナプロピオンサン エステルユウドウタイノセイゾウホウ
JPS53112837A (en) 1977-03-11 1978-10-02 Mitsui Toatsu Chem Inc Method of isolation of alpha-phenylpropionic acid compound
EP0070714B1 (en) 1981-07-20 1986-05-07 The Upjohn Company Use of ibuprofen or flurbiprofen for the manufacture of a medicament for treating respiratory disorders
GB8528195D0 (en) 1985-11-15 1985-12-18 Boots Co Plc Therapeutic compositions
US4873231A (en) 1986-04-08 1989-10-10 Smith Walton J Decreasing the toxicity of an ibuprofen salt
DE3621036A1 (de) * 1986-06-24 1988-01-07 Merckle Gmbh Fluessige ibuprofen-zubereitungen
US4684666A (en) 1986-08-19 1987-08-04 Haas Pharmaceuticals, Inc. Stabilized liquid analgesic compositions
ES2055685T3 (es) 1986-11-14 1994-09-01 Puetter Medice Chem Pharm Procedimiento para la obtencion de un medicamento que contiene ibuprofen.
GB8701392D0 (en) 1987-01-22 1987-02-25 Boots Co Plc Therapeutic agents
US4851444A (en) 1987-07-10 1989-07-25 Analgesic Associates Onset-hastened/enhanced analgesia
US4980375A (en) 1987-07-10 1990-12-25 Sterling Drug Inc. Onset-hastened/enhanced antipyretic response
IT1222013B (it) 1987-07-10 1990-08-31 Chimica Profarmaco Spa Ind Processo di risoluzione ottica di acido 2 (6 metossi 2 naftil) propionico
US4861797A (en) 1987-10-15 1989-08-29 Oratech Pharmaceutical Development Corporation Liquid ibuprofen compositions and methods of making them
US4859704A (en) 1987-10-15 1989-08-22 Oratech Pharmaceutical Development Corporation Water soluble ibuprofen compositions and methods of making them
IT1217988B (it) 1988-01-28 1990-03-30 Ind Chimica Profarmaco Spa Procedimento per la risoluzione ottica di un pacemo
DE3814887C1 (https=) * 1988-05-02 1989-09-21 Medice Chem.-Pharm. Fabrik Puetter Gmbh & Co Kg, 5860 Iserlohn, De
US4831147A (en) 1988-07-05 1989-05-16 The Dow Chemical Company Resolution of enantiomers of herbicidal 2-(4-aryloxyphenoxy) propionates by chiral two-phase extraction
CH677606A5 (https=) 1988-07-12 1991-06-14 Aesculapius Pharma Sa
DE3838431A1 (de) 1988-11-12 1990-05-17 Bayer Ag Ibuprofen-brausezubereitungen
US5032384A (en) * 1989-01-27 1991-07-16 Block Drug Company, Inc. Compositions and method for the treatment of disease
AU643210B2 (en) 1989-05-16 1993-11-11 Medice Chem.-Pharm. Fabrik Putter Gmbh & Co. Kg Process for preparing optically active 2-aryl-alkanoic acids, in particular 2-ayrl-propionic acids
US5100918A (en) 1989-05-25 1992-03-31 Sterling Drug, Inc. Prevention or treatment of sunburn using the S(+) isomer of ibuprofen
US4946997A (en) 1989-06-07 1990-08-07 Merck & Co., Inc. Racemization of a carboxylic acid
DE3922441A1 (de) * 1989-07-07 1991-01-17 Pharmatrans Sanaq Ag Ibuprofen- und s-(+)-ibuprofen-zubereitungen und verfahren zu ihrer herstellung
GB8920693D0 (en) 1989-09-13 1989-10-25 Nicholas Kiwi Pty Ltd Non-effervescent ibuprofen compositions
US5200558A (en) 1989-10-17 1993-04-06 Merck & Co., Inc. S(+)-ibuprofen-L-amino acid and S(+)-ibuprofen-D-amino acid as onset-hastened enhanced analgesics
US4994604A (en) 1990-01-10 1991-02-19 Merck & Co., Inc. Formation and resolution of ibuprofen lysinate
US5015764A (en) * 1990-06-18 1991-05-14 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5164398A (en) 1991-04-01 1992-11-17 Merck & Co., Inc. Ibuprofen-antitussive combinations
UA34430C2 (uk) * 1991-05-13 2001-03-15 Дзе Бутс Компані Плс S(-)-2-(4-ізобутилфеніл)пропіонат натрію дигідрат, придатний для лікування запалення, болю і гіпертермії, фармацевтична композиція на його основі та спосіб одержання s(-)-2-(4-ізобутилфеніл)пропіонату натрію
US5189208A (en) 1991-07-01 1993-02-23 Ethyl Corporation Ibuprofen resolution
US5302751A (en) 1992-01-21 1994-04-12 Ethyl Corporation Profen resolution
US5235095A (en) 1992-01-24 1993-08-10 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5235101A (en) 1992-01-24 1993-08-10 Ethyl Corporation Preparation by flotation of optically active aliphatic carboxylic acids
US5235100A (en) 1992-01-24 1993-08-10 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5220053A (en) 1992-01-24 1993-06-15 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5248213A (en) 1992-01-27 1993-09-28 Plastek Industries, Inc. Seal for roll-on dispenser
US5278337A (en) 1992-10-14 1994-01-11 Ethyl Corporation Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids
US5260482A (en) 1992-10-14 1993-11-09 Ethyl Corporation Enantiomeric resolution
US5248813A (en) 1992-10-14 1993-09-28 Ethyl Corporation Enantiomeric resolution
US5256816A (en) 1992-10-14 1993-10-26 Ethyl Corporation Enantiomeric resolution

Also Published As

Publication number Publication date
JPH06507159A (ja) 1994-08-11
CZ240593A3 (en) 1994-03-16
YU50292A (sh) 1995-03-27
TW304940B (https=) 1997-05-11
AU1671192A (en) 1992-12-30
WO1992020334A1 (en) 1992-11-26
BG98214A (bg) 1994-07-29
DK0584108T3 (da) 2000-10-09
RO118371B1 (ro) 2003-05-30
CA2102530C (en) 2003-07-29
US6525214B1 (en) 2003-02-25
IL101818A0 (en) 1992-12-30
US5696165A (en) 1997-12-09
NO305696B1 (no) 1999-07-12
PT100476B (pt) 1999-09-30
FI934964A0 (fi) 1993-11-10
IL101818A (en) 1999-08-17
DE69231359D1 (de) 2000-09-21
SK125993A3 (en) 1994-04-06
EG20309A (en) 1998-10-31
JP3326174B2 (ja) 2002-09-17
BG61676B1 (bg) 1998-03-31
GEP20002013B (en) 2000-04-10
MX9202215A (es) 1992-11-01
CN1068734A (zh) 1993-02-10
PT100476A (pt) 1993-08-31
NO982500D0 (no) 1998-06-02
HU9303220D0 (en) 1994-03-28
KR100198044B1 (ko) 1999-06-15
RU2145219C1 (ru) 2000-02-10
US6242000B1 (en) 2001-06-05
MY110267A (en) 1998-03-31
NZ242640A (en) 1993-11-25
NO934102D0 (no) 1993-11-12
UA34430C2 (uk) 2001-03-15
HU219242B (en) 2001-03-28
US5696165B1 (en) 2000-12-05
ES2148175T3 (es) 2000-10-16
AU658415B2 (en) 1995-04-13
SK279279B6 (sk) 1998-09-09
CN1068305C (zh) 2001-07-11
CZ281717B6 (cs) 1996-12-11
EP0584108B1 (en) 2000-08-16
FI109994B (fi) 2002-11-15
IE921393A1 (en) 1992-11-18
HUT67034A (en) 1995-01-30
NO304678B1 (no) 1999-02-01
ATE195417T1 (de) 2000-09-15
CA2102530A1 (en) 1992-11-14
NO934102L (no) 1993-11-12
DE69231359T2 (de) 2001-02-08
EP0584108A1 (en) 1994-03-02
GR3034780T3 (en) 2001-02-28
FI934964L (fi) 1993-11-10
NO982500L (no) 1993-11-12

Similar Documents

Publication Publication Date Title
YU48928B (sh) Postupak dobijanja ibuprofenskog derivata
ES8404355A1 (es) "procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables".
FI885623A7 (fi) Menetelmä lääkeaineina käyttökelpoisten substituoitujen propaani-fosfiinihappoyhdisteiden valmistamiseksi
YU47159B (sh) Postupak za dobijanje derivata saharoze
KR890001987A (ko) 테트라하이드로카바졸 1-알카노산
ES2156381T3 (es) Sales estables no higroscopicas de l(-)carnitina y alcanoil-l(-)carnitinas, un procedimiento para su preparacion y composiciones solidas, administrables por via oral, que contienen tales sales.
DK166186D0 (da) Fremgangsmaade til fremstilling af quinolin-3-carboxylsyre forbindelser
SE8501744L (sv) N-metyl-d-glukaminsaltet av d-2-(5-bromo-6-metoxi-2-naftyl)-propionsyra
FR2517670B1 (fr) Sel d'acide (+)-2-(2-fluoro-4-biphenylyl)propionique, procede pour sa preparation et composition pharmaceutique le contenant
GB1377209A (en) Optically active basically substituted phenylacetonitriles
DK237483A (da) Fremgangsmaade til fremstilling af propionsyrederivater
PT83667B (pt) Processo para a preparacao de acidos e esteres {{{(3-piridinil)metileno}amino}oxi}-alcanoicos e de composicoes farmaceuticas que os contenham
JPS55118455A (en) Method of collecting optically active d-alpha-methyl-beta- mercapto propionic acid derivative
DE3060670D1 (en) Process for the separation of the two optical isomers of 1-(o-methoxyphenoxy)-3-isopropylamino-propan-2-ol, optical isomers obtained thereby and pharmaceutical compositions of the levorotatory antipode thereof
EP0508133A3 (en) Method of preparation of l-carnitine from d,l-carnitine nitrile salts
RU94027692A (ru) Способ кристаллизации метионина
ES515895A0 (es) "un procedimiento para la preparacion de un compuesto de imidazol".
FR2665897B1 (fr) Procede de transformation de l'acide (benzoyl-3 phenyl)-2 propionique-r(-) en isomere s(+).
JPS56108737A (en) Method for obtaining optically active 2*22dimethyll33 2*22 dichlorovinyl cyclopropanecarboxylic acid
ES8603826A1 (es) Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias
ES2003994A6 (es) Procedimiento de preparacion de nuevas 2-cloro-12-(3-dimetilamino-2-metilpropil)-12h-dibenzo(d,g) (i,3,6) dioxazocinas opticamente activas y de sus sales de adicion acidas farmaceuticamente aceptables
ES8600759A1 (es) Procedimiento para preparar 2-(fenetil)-5-((3, 4-metilendioxi)- -hidroxibencil)-pirrolidina
FR2566425B1 (fr) Procede pour la production de 2-(phenyl substitue) acide propionique par micro-organisme
Moon et al. Facile Synthesis of (2S, 3R)-3-Amino-2-hydroxy-4-(4'-hydroxyphenyl) butanoic Acid. Application to the Synthesis of Inhibitors of Aminopeptidases
JPS54151954A (en) 2-aminomethylphenol derivative and its preparation