CN106748721A - 一种2‑氯‑5‑碘苯甲酸的制备方法 - Google Patents
一种2‑氯‑5‑碘苯甲酸的制备方法 Download PDFInfo
- Publication number
- CN106748721A CN106748721A CN201611010716.5A CN201611010716A CN106748721A CN 106748721 A CN106748721 A CN 106748721A CN 201611010716 A CN201611010716 A CN 201611010716A CN 106748721 A CN106748721 A CN 106748721A
- Authority
- CN
- China
- Prior art keywords
- chloro
- iodo
- acids
- reaction
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611010716.5A CN106748721B (zh) | 2016-11-17 | 2016-11-17 | 一种2-氯-5-碘苯甲酸的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611010716.5A CN106748721B (zh) | 2016-11-17 | 2016-11-17 | 一种2-氯-5-碘苯甲酸的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106748721A true CN106748721A (zh) | 2017-05-31 |
CN106748721B CN106748721B (zh) | 2019-06-21 |
Family
ID=58968608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201611010716.5A Active CN106748721B (zh) | 2016-11-17 | 2016-11-17 | 一种2-氯-5-碘苯甲酸的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106748721B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107673990A (zh) * | 2017-10-31 | 2018-02-09 | 上海同昌生物医药科技有限公司 | 一种2‑溴‑5‑碘苯甲酸的制备方法 |
CN110078613A (zh) * | 2019-05-31 | 2019-08-02 | 杭州科耀医药科技有限公司 | 一种2-卤-5-碘苯甲酸的合成方法 |
CN113214041A (zh) * | 2021-04-29 | 2021-08-06 | 河北唯达生物医药产业技术研究有限公司 | 一种新型的制备3-碘-2溴甲苯的方法 |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3624142A (en) * | 1964-09-10 | 1971-11-30 | Merck & Co Inc | Substituted biphenyl acetic acid derivatives |
US4328162A (en) * | 1980-09-05 | 1982-05-04 | Eastman Kodak Company | Process for preparing 9,11-unsaturated steroidal compound from the corresponding saturated steroidal compound |
CN87106482A (zh) * | 1986-09-19 | 1988-03-30 | 拜尔公司 | 苯甲酸衍生物的制备方法 |
US5003103A (en) * | 1989-11-20 | 1991-03-26 | Occidental Chemical Corporation | Preparation of 2-choloro-4,5-difluorobenzoic acid from 4,5-difluorophthalic anhydride of 4,5-difluorophthalic acid |
CN1426388A (zh) * | 2000-04-28 | 2003-06-25 | 日本农药株式会社 | 生产2-卤代苯甲酸的方法 |
CN1812954A (zh) * | 2003-07-03 | 2006-08-02 | 三菱瓦斯化学株式会社 | 5-碘代-2-甲基苯甲酸的制备方法 |
CN101497565A (zh) * | 2009-03-12 | 2009-08-05 | 常州工程职业技术学院 | 一种2-氟-6-碘苯甲酸的合成方法 |
CN101570522A (zh) * | 2009-04-03 | 2009-11-04 | 天津市农药研究所 | 适于工业化生产活化酯的合成方法 |
CN103420902A (zh) * | 2012-05-18 | 2013-12-04 | 苏州爱斯鹏药物研发有限责任公司 | 一种2-氯-4-碘-5-甲基吡啶的制备方法 |
CN103965020A (zh) * | 2014-05-06 | 2014-08-06 | 启东东岳药业有限公司 | 制备5-碘-2-溴苄醇的方法 |
CN104086361A (zh) * | 2014-07-25 | 2014-10-08 | 南通市华峰化工有限责任公司 | 一种2-氯-5-碘苯甲酸的制备方法 |
CN104193616A (zh) * | 2014-05-21 | 2014-12-10 | 江苏德峰药业有限公司 | 一种2-氯-5-碘苯甲酸的合成方法 |
CN104744227A (zh) * | 2013-12-25 | 2015-07-01 | 重庆博腾制药科技股份有限公司 | 一种5-溴-2-氯苯甲醛的制备方法 |
-
2016
- 2016-11-17 CN CN201611010716.5A patent/CN106748721B/zh active Active
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3624142A (en) * | 1964-09-10 | 1971-11-30 | Merck & Co Inc | Substituted biphenyl acetic acid derivatives |
US4328162A (en) * | 1980-09-05 | 1982-05-04 | Eastman Kodak Company | Process for preparing 9,11-unsaturated steroidal compound from the corresponding saturated steroidal compound |
CN87106482A (zh) * | 1986-09-19 | 1988-03-30 | 拜尔公司 | 苯甲酸衍生物的制备方法 |
US5003103A (en) * | 1989-11-20 | 1991-03-26 | Occidental Chemical Corporation | Preparation of 2-choloro-4,5-difluorobenzoic acid from 4,5-difluorophthalic anhydride of 4,5-difluorophthalic acid |
CN1426388A (zh) * | 2000-04-28 | 2003-06-25 | 日本农药株式会社 | 生产2-卤代苯甲酸的方法 |
CN1812954A (zh) * | 2003-07-03 | 2006-08-02 | 三菱瓦斯化学株式会社 | 5-碘代-2-甲基苯甲酸的制备方法 |
CN101497565A (zh) * | 2009-03-12 | 2009-08-05 | 常州工程职业技术学院 | 一种2-氟-6-碘苯甲酸的合成方法 |
CN101570522A (zh) * | 2009-04-03 | 2009-11-04 | 天津市农药研究所 | 适于工业化生产活化酯的合成方法 |
CN103420902A (zh) * | 2012-05-18 | 2013-12-04 | 苏州爱斯鹏药物研发有限责任公司 | 一种2-氯-4-碘-5-甲基吡啶的制备方法 |
CN104744227A (zh) * | 2013-12-25 | 2015-07-01 | 重庆博腾制药科技股份有限公司 | 一种5-溴-2-氯苯甲醛的制备方法 |
CN103965020A (zh) * | 2014-05-06 | 2014-08-06 | 启东东岳药业有限公司 | 制备5-碘-2-溴苄醇的方法 |
CN104193616A (zh) * | 2014-05-21 | 2014-12-10 | 江苏德峰药业有限公司 | 一种2-氯-5-碘苯甲酸的合成方法 |
CN104086361A (zh) * | 2014-07-25 | 2014-10-08 | 南通市华峰化工有限责任公司 | 一种2-氯-5-碘苯甲酸的制备方法 |
Non-Patent Citations (5)
Title |
---|
SPALDING, DAVID P ET AL: "Heterocyclic basic compounds. XV. Benzacridine derivatives", 《JOURNAL OF ORGANIC CHEMISTRY》 * |
叶飞等: "2-氯-5-碘苯甲酸的合成", 《应用化工》 * |
李克华主编: "《精细有机合成》", 31 August 2007 * |
贾建洪等: "5-硝基水杨酸的合成新工艺研究", 《浙江工业大学学报》 * |
高鸿宾主编: "《有机化学》", 31 May 2005, 高等教育出版社 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107673990A (zh) * | 2017-10-31 | 2018-02-09 | 上海同昌生物医药科技有限公司 | 一种2‑溴‑5‑碘苯甲酸的制备方法 |
CN110078613A (zh) * | 2019-05-31 | 2019-08-02 | 杭州科耀医药科技有限公司 | 一种2-卤-5-碘苯甲酸的合成方法 |
CN110078613B (zh) * | 2019-05-31 | 2022-04-22 | 杭州科耀医药科技有限公司 | 一种2-卤-5-碘苯甲酸的合成方法 |
CN113214041A (zh) * | 2021-04-29 | 2021-08-06 | 河北唯达生物医药产业技术研究有限公司 | 一种新型的制备3-碘-2溴甲苯的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN106748721B (zh) | 2019-06-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106699570A (zh) | (2‑氯‑5‑碘苯基)(4‑氟苯基)甲酮的合成方法 | |
CN103980263B (zh) | 卡格列净的合成工艺 | |
CN106748721A (zh) | 一种2‑氯‑5‑碘苯甲酸的制备方法 | |
CN101235034A (zh) | 恩替卡韦的合成方法 | |
CN104086545A (zh) | 1-(2-氟苄基)-1H-吡唑并[3,4-b]吡啶-3-甲脒盐酸盐的合成方法 | |
CN103709164B (zh) | 一种腺嘌呤的合成方法 | |
CN106946887B (zh) | 一种引入催化剂优化合成双嘧达莫的制备方法 | |
CN101792387B (zh) | 2,3,4-三甲氧基苯甲酸的制备方法 | |
CN103923020A (zh) | 一种2-丙硫基-4,6-二氯-5-氨基嘧啶的制备方法 | |
CN102351790A (zh) | 7-溴-6-氯-4(3h)-喹诺酮的合成方法 | |
CN102093288B (zh) | 一种水合三氯吡啶肼的制备方法 | |
CN103641686A (zh) | 2,3,5,6-四氟-1,4-对苯二甲醇的合成方法 | |
CN103896858B (zh) | 胞嘧啶的制备工艺 | |
CN102127081A (zh) | 一种腺嘌呤的制备方法 | |
CN107266311B (zh) | 一种利用微流体芯片反应器连续制备α-酮酸酯的方法 | |
CN101696185B (zh) | 6-硝基-s-(-)-吲哚啉-2-甲酸的合成方法 | |
CN105294686B (zh) | 一种利奥西呱的制备方法 | |
CN104761548B (zh) | 一种稳定同位素标记的二苯基磺酰胺类药物的制备方法 | |
CN102643277A (zh) | 更昔洛韦的精制方法 | |
CN107325057A (zh) | 一种磺胺‑2,6‑二甲氧基嘧啶的制备方法 | |
CN209584049U (zh) | N-氰乙基-n-苄基苯胺的生产设备 | |
CN108409648B (zh) | 一种甲苯磺酸索拉非尼相关中间体的制备方法 | |
CN106316950A (zh) | 一种制备格列喹酮的方法 | |
CN107298656A (zh) | 替吡嘧啶中间体以及替吡嘧啶中间体、替吡嘧啶、替吡嘧啶盐酸盐的制备方法 | |
CN111499530B (zh) | 一步制备氨基邻苯二甲酸单甲酯的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address |
Address after: 251400 No. 12, Taixing East Street, Jibei Economic Development Zone, Jiyang District, Jinan City, Shandong Province Patentee after: Shandong Baoyuan Pharmaceutical Co.,Ltd. Address before: Strong in Jiyang County of Ji'nan City, 251400 North Street, Shandong Province Economic Development Zone Patentee before: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. |
|
CP03 | Change of name, title or address | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of 2-chloro-5-iodiobenzoic acid Effective date of registration: 20221130 Granted publication date: 20190621 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan science and technology innovation center sub branch Pledgor: Shandong Baoyuan Pharmaceutical Co.,Ltd. Registration number: Y2022980023658 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |