CN106729007A

CN106729007A - Treat Chinese medicine of child's hand-foot-and-mouth disease and preparation method thereof

Info

Publication number: CN106729007A
Application number: CN201611022359.4A
Authority: CN
Inventors: 袁子娇
Original assignee: Guangxi University
Current assignee: Guangxi University
Priority date: 2016-11-21
Filing date: 2016-11-21
Publication date: 2017-05-31

Abstract

Chinese medicine the present invention relates to treat child's hand-foot-and-mouth disease, is made up of the medicine of following weight portion：Vitamin B _ 80~130 part, vitamin C _ 80~130 part, 80~100 parts of honeysuckle, 75~100 parts of caulis lonicerae, 75~100 parts of carrot, 60~90 parts of Radix Isatidis, 60~90 parts of centella, 50~85 parts of alkanet, 45~60 parts of the fruit of summer cypress, 35~50 parts of the capsule of weeping forsythia, 35~50 parts of the coptis, 35~50 parts of favus skin, 35~50 parts of the radix paeoniae rubrathe, 25~50 parts of the leaf of bamboo, 25~50 parts of peppermint, 25~50 parts of the root bark of tree peony, 20~35 parts of new lotus leaf, 20~35 parts of Radix Glycyrrhizae, 10~25 parts of Smallfruit Fig Aerial Root, 10~25 parts of chushan lip-fern herb, 15~35 parts of giant knotweed, 15~35 parts of 15~35 parts of rattletop and cape jasmine, also disclose its preparation method.The all medicine phases of the present invention are closed, and each medicinal material mutually acts synergistically, so as to easily treat child's hand-foot-and-mouth disease.

Description

Treat Chinese medicine of child's hand-foot-and-mouth disease and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to the Chinese medicine for the treatment of child's hand-foot-and-mouth disease and its preparation side Method.

Background technology

Hand-Food-Mouth Disease is mainly and is caused by enterovirus, the baby of less than 4 years old it is easy this disease.Annual summer and autumn Friendship have morbidity, September is peak period.Infant has suffered from hand-foot-and-mouth disease, is not only to cough but also slobber, and does not like also to eat, throat In also have some vesicles.Most typical onset process is moderate heat heating (body temperature is below 39 DEG C), and then pharyngalgia occurs, Child shows as slobbering, food refusal.There is no the infant of complication, one week or so can recovery from illness.A small number of infants have nervous system Symptom, concurrent aseptic meningitis and skin scabies secondary infection, but rarely sequelae.

Hand-Food-Mouth Disease Acute onset, heating；Oral mucosa occurs being dispersed in bleb, and grain of rice size, pain is obvious；Palm Or the big exanthema vesiculosum of the grain of rice occurs in foot palm part, buttocks or knee can occasionally be involved.There is inflammatory blush around bleb, liquid is less in blister. Part infant can be with symptoms such as cough, runny nose, poor appetite, Nausea and vomiting, headaches.

Intraoral bleb causes ulcer after having broken, and some parents think child's infection of the upper respiratory tract, do not have timely band Child goes to a doctor.And as treatment not in time can concurrently encephalitis, pneumonia, myocarditis, trigger vitals to damage.Indivedual children with serious disease are such as Fruit disease development is fast, causes death.

The treatment for this disease is mostly to use western medicine at present, but it is big to pharmacological dependence to there is patient, and medicine The problems such as having certain toxic and side effect to the organ of child patient.Therefore, being badly in need of developing the Chinese medicine that a kind of safety has no side effect Preparation breaks away from the pain that hand foot and mouth disease brings helping child patient.

The content of the invention

It is an object of the invention to：For above-mentioned deficiency, the invention provides in treatment child's hand-foot-and-mouth disease Medicine and preparation method thereof.The present invention using all medicine phases close, with it is clearing heat and detoxicating, removing toxic substances eliminating dampness, eliminating dampness analgesic, it is promoting blood circulation and removing blood stasis, kill The effect that worm is antipruritic, remove necrosis and promote granulation, the active component in each medicinal material mutually acts synergistically, so that easily treatment child brothers mouthful Disease, reaches the effect treated both principal and secondary aspect of disease.

In order to achieve the above object, present invention employs following technical scheme：

A kind of Chinese medicine for treating child's hand-foot-and-mouth disease, is made up of the medicine of following weight portion：Vitamin B _ 80~130 part, dimension life Plain C_80~130 part, 80~100 parts of honeysuckle, 75~100 parts of caulis lonicerae, 75~100 parts of carrot, 60~90 parts of Radix Isatidis, 60~90 parts of centella, 50~85 parts of alkanet, 45~60 parts of the fruit of summer cypress, 35~50 parts of the capsule of weeping forsythia, 35~50 parts of the coptis, favus skin 35~50 parts, 35~50 parts of the radix paeoniae rubrathe, 25~50 parts of the leaf of bamboo, 25~50 parts of peppermint, 25~50 parts of the root bark of tree peony, 20~35 parts of new lotus leaf, 20~35 parts of Radix Glycyrrhizae, 10~25 parts of Smallfruit Fig Aerial Root, 10~25 parts of chushan lip-fern herb, 15~35 parts of giant knotweed, 15~35 parts of rattletop and cape jasmine 15~ 35 parts.

Further, the Chinese medicine of described treatment child's hand-foot-and-mouth disease, is made up of the medicine of following weight portion：Vitamin B _ 95~115 parts, vitamin C _ 95~115 part, 85~95 parts of honeysuckle, 85~90 parts of caulis lonicerae, 85~90 parts of carrot, plate it is blue 70~80 parts of root, 70~80 parts of centella, 65~70 parts of alkanet, 50~55 parts of the fruit of summer cypress, 40~45 parts of the capsule of weeping forsythia, the coptis 40~ 45 parts, 40~45 parts of favus skin, 40~45 parts of the radix paeoniae rubrathe, 35~40 parts of the leaf of bamboo, 35~40 parts of peppermint, 35~40 parts of the root bark of tree peony, fresh lotus 25~30 parts of leaf, 25~30 parts of Radix Glycyrrhizae, 15~20 parts of Smallfruit Fig Aerial Root, 15~20 parts of chushan lip-fern herb, 20~30 parts of giant knotweed, 20~30 parts of rattletop And 20~30 parts of cape jasmine.

Further, the Chinese medicine of described treatment child's hand-foot-and-mouth disease, is made up of the medicine of following weight portion：Vitamin B _ 105 parts, it is vitamin C _ 105 part, 90 parts of honeysuckle, 87 parts of caulis lonicerae, 88 parts of carrot, 75 parts of Radix Isatidis, 75 parts of centella, purple 67 parts of grass roots, 53 parts of the fruit of summer cypress, 42 parts of the capsule of weeping forsythia, 43 parts of the coptis, 43 parts of favus skin, 43 parts of the radix paeoniae rubrathe, 37 parts of the leaf of bamboo, 37 parts of peppermint, 25 parts of 38 parts of the root bark of tree peony, 28 parts of new lotus leaf, 27 parts of Radix Glycyrrhizae, 17 parts of Smallfruit Fig Aerial Root, 18 parts of chushan lip-fern herb, 25 parts of giant knotweed, 25 parts of rattletop and cape jasmine.

Further, the preparation method of the Chinese medicine of described treatment child's hand-foot-and-mouth disease, comprises the steps of：

（1）By weight ratio, caulis lonicerae, alkanet, the fruit of summer cypress, Radix Glycyrrhizae, Smallfruit Fig Aerial Root, chushan lip-fern herb, peppermint, the root bark of tree peony are gone respectively It is miscellaneous, clean after, the alcohol reflux 2 times that 12~16 times of weight concentrations of caulis lonicerae are 60~75% is added, twice in 90 ± 2 DEG C of water Bath flows back, and the time of backflow is 4~5h for the first time, and second time of backflow is 2~3h, merges extract solution, to extract solution The middle activated carbon for adding 1.5~3.0 times of weight of caulis lonicerae shakes 15~20min, and natural filtration obtains stream immersion liquid；

（2）Radix Isatidis, the capsule of weeping forsythia, the coptis, favus skin are put into container, giant knotweed, rattletop, cape jasmine that addition is soaked, add plate blue 5~6h is boiled in 10~15 times of weight 5~7h of distilled water immersion of root, heating, and filtrate and filter residue is collected by filtration, to adding plate in filter residue 3~4h is boiled in 8~10 times of weight distilled water heating of blue root, and filtrate is collected by filtration, and merges filtrate twice, obtains liquid；

（3）Juice is smash in mixing after the radix paeoniae rubrathe, the leaf of bamboo, new lotus leaf, centella, honeysuckle, carrot are cleaned respectively, and filter cleaner is obtained Juice；

（4）By vitamin B, vitamin C, step（1）Stream immersion liquid, step（2）Liquid and step（3）Juice mixing it is equal It is even, then by filling after homogenizer homogeneous, microwave disinfection, obtain final product the Chinese medicine for the treatment of child's hand-foot-and-mouth disease.

Further, the filter type that the filtering is used is that nylon falls net filtration.

Further, in step（4）, the condition of the homogenization is：Pressure is 13~17Mpa, and temperature is 60~70 ℃；The temperature of the microwave disinfection be 60~65 DEG C, the time be 2~3h, frequency be 2200~2500MHz, power be 6~ 10kw。

The property of medicine of Chinese medicine used of the invention is as follows：

Vitamin B, English name Vitamin B, B family vitamin is the essential nutrient of all tissues, is that food is released The key of exoergic amount, and liver has compared with substantial connection.

Vitamin C, English name：Vitamin C, in vivo, vitamin C is a kind of antioxidant, can help plant Resistance arid, ozone and ultraviolet, from the threat of free radical, vitamin C is also simultaneously a kind of coenzyme to protection body, with slow Solution leucoderma, the effect for reducing cancer morbidity.

Honeysuckle is described as clearing heat and detoxicating good medicine from ancient times.The sweet cold air fragrance of its property, without injuring one's stomach, fragrance is thoroughly for clear heat with drugs of sweet flavour and cold nature Up to again can eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile diseases, such as body heat, dermexanthesis, hair spot, heat The diseases such as carbuncle carbuncle, abscess of throat, equal effect is significant.

Caulis lonicerae：Also known as big climbing fig, bigcatkin willow rattan, Japanese Stephania Root, perennial half evergreen voluble shrub, stem is hollow, the close life of sprout Pubescence.Odorless, old branch mildly bitter flavor, spray is lightly seasoned.Impurity is removed, is cleaned, vexed profit, segment, dried.With clearing heat and detoxicating, dredge The curative effect of wind and removing obstruction in channels.Can be used for warm disease heating, sore and toxic, toxic-heat and blood stasis, beriberoid pyretic arthralgia

Carrot：It is sweet, pungent, it is mild-natured；Returns spleen, liver, lung channel.Nvigorating the spleen and in, nourishing liver for improving eyesight, preventing phlegm from forming and stopping coughing is clearing heat and detoxicating.Main spleen Empty deficiency of food, physically weak weak, abdominal pain, lets out dysentery, blurring of vision, night blindness, cough and asthma, pertussis, abscess of throat, measles, varicella, furuncle It is swollen, burn, anal fistula.《The south of the Five Ridges is gathered medicinal herbs record》Carry：" it is all go out numb acne, drunk with this pan-fried water all the time, can heat reliving and toxin-eliminating, using fresh herb and dry With.”

Radix Isatidis：Bitter, it is cold in nature；Return liver, stomach.It is clearing heat and detoxicating, cool blood relieving sore-throat.Main febrile virulent maculae, high heat headache, infection with swollen head Epidemic disease, scarlet fever, erysipelas, mumps, larynx numbness, sore swells, varicella, measles, hepatitis, influenza.《Book on Chinese herbal medicine is just read》Carry：" plate is blue Root is indigo-blue, and its function nature and flavor and indigo-blue leaf are same, can enter liver stomach blood system, but heat-clearing, detoxify, ward off epidemic disease, desinsection. But leaf master dissipates, the main drop of root, this different ear again in." modern medicine study confirms that this product has antibacterial, antivirus action.

Centella：It is bitter, pungent, it is cold in nature；Return lung, spleen, kidney, bladder warp.Clearing heat and promoting diuresis, promoting blood circulation and hemostasis, removing toxicity for detumescence.Main hair Heat, cough and asthma, abscess of throat, intestines are dysentery, jaundice with damp-heat pathogen, oedema, stranguria, hematuria, bleeding from five sense organs or subcutaneous tissue, dysmenorrhoea, uterine bleeding, erysipelas, scrofula Scrofula, close pyogenic infections from tumour or sore, herpes zoster, treating swelling and pain by traumatic injury, traumatism and bleeding, snake bite and insect sting.《This warp》Carry：" main big heat, dislikes sore, ulcer, leaching Excessive, red Blaze, skin is red, body heat.”

Asian puccoon alias gromwell root, radix macrotomiae, are the dry roots of comfrey lithospermum euchromum Royle, Asian puccoon or arnebia guttata Bunge.Asian puccoon property It is cold, bitter, salty, the thoughts of returning home, Liver Channel, with clearing heat and cooling blood, promoting blood circulation, the effect for promoting eruption of detoxifying.It is mainly used in treating blood-heat and toxin exuberance, spot Rash purple is black, measles without adequate eruption, sore, eczema, scald, clearing heat and cooling blood, for measles, pyreticosis ecchymosis, and eczema, hematuria, blood strangury, Bloody flux, sore, erysipelas, burn, constipation with heat retention.Contain Acetyl-shikonin, isobutyryl shikonin, β, beta-dimethyl propylene in Asian puccoon Shikonin, β- Hydroxyisovalerylshikonin, 3,4- dimethyl pentene -3- acyl group shikonins etc..Asian puccoon has antibacterial, antiinflammatory action, It is inhibited to virus, also there is inhibitory action to staphylococcus aureus, Bacterium prodigiosum, pyogenic baeceria, Escherichia coli etc..Asian puccoon Quinone and Acetyl-shikonin also have antiinflammatory action, and topical application can promote wound healing；There is excitation to the circulatory system；It is anti- Function of tumor, to having certain curative effect to chorioepithelioma and chorioadenoma；Antipyretic and diuresis.

The fruit of summer cypress, Chinese medicine name.Taste is pungent, hardship, it is cold in nature, return kidney, bladder warp, clearing heat and promoting diuresis, dispelling wind and arresting itching is puckery for urine Bitterly, pruritus vulvae under band, rubella, eczema, pruitus.《Compendium of Materia Medica》：Cystocele lump in the abdomen.Wine clothes are ground in the critical person of hernia, stir-fry；Fox hernia the moon ovum Disease, the same to bighead atractylodes rhizome, osmanthus heart end clothes.

The capsule of weeping forsythia capsule of weeping forsythia is the dry fruit of the Oleaceae plants capsule of weeping forsythia, cold nature, bitter, return lung, the heart, small intestinl channel.The capsule of weeping forsythia has Have clearing heat and detoxicating, the function of dispersing swelling and dissipating binds, be mainly used in treat ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease from the beginning of, Warm is joined the army, hyperpyrexia polydipsia, coma hair spot, heat gonorrhea renal shutdown.Weeping forsythia concentrated decoction has antibacterial action in vitro, can suppress typhoid fever bar Bacterium, paratyphosum Bacterium, Escherichia coli, shigella dysenteriae, corynebacterium diphtheriae and comma bacillus, staphylococcus, streptococcus etc., forsythol is The active ingredient of antibacterial；The alcohol extracting thing of the capsule of weeping forsythia has anti-leptospira effect in vitro；Capsule of weeping forsythia flooding agent is in vitro to star Shape nocadia some inhibitory action；The capsule of weeping forsythia can suppress emetic action, and it is probably to suppress medulla oblongata that action principle is told in the town of the capsule of weeping forsythia Chemoreceptor trigger zone.(also known as olive folic acid) containing oleanolic acid in the pericarp of the capsule of weeping forsythia, therefore have cardiac stimulant, diuresis.

The coptis connects also known as cloud company, refined company, river, taste connects, Rhizoma Coptidis, is that the ranunculaceae plant coptis, the triangle leaf coptis or cloud connect Dry rhizome.Bitter cold in nature, the thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.With heat-clearing and damp-drying drug, purging intense heat and detonicating.For treating heat Disease and evil enters the hyperpyrexia of the heart channel of Hang-Shaoyin；It is irritated；Delirium or heat contain the hematemesis for compeling the absurd row of blood；Damp and hot feeling of fullness, vomits acid regurgitation, and rush down dysentery, jaundice is high Hot coma, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache is quenched one's thirst, carbuncle swells furunculosis；Control eczema, wet sore, duct outward Suppurate.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Jamaicin, coptisine, epiberberine, small is mainly contained in the coptis The alkaloids such as the red alkali of bark of a cork tree, jateorrhizine, magnoflorine, worenine, palmatine, jateorrhizine, also containing obakunone, Ah The compositions such as Wei's acid, obakulactone.Modern pharmacological research shows that the coptis has antibacterial, an antifungic action, antivirus action, anti-inflammatory and Anti-CaM antibody etc..PR8 plants of Huanglian Decoction infected by influenza, influenza A virus 56-S8 plants, it is FMl plants of A-prime virus, B-mode Influenza virus Lee plants, 1233 plants of inner mold influenza virus have inhibitory action；There is inhibitory action to hepatitis B virus DNA.

Favus skin：It is bitter, salty, it is cold in nature；Returns spleen, lung, small intestine, stomach, bladder warp.Heat-clearing and damp-drying drug, dispelling wind and arresting itching, removing toxic substances.It is main Rubella caused by wind-heat wet poison, eczema, mange, jaundice, damp-heat arthralgia.《Haigoushen》Carry：" control all heat toxin wind, foul wind, wind sore, Mange is red rotten, and eyebrow hair takes off crisp, musculus cutaneus urgency, high fever aversion to cold；Principal solution heat Huang, wine Huang, acute febrile, paddy Huang, labor Huang etc..”

The wooden Chinese herbaceous peony of radix paeoniae rubrathe another name, red Chinese herbaceous peony.Radix paeoniae rubrathe cold nature, sour, hardship, Return liver, the spleen channel.With clearing heat and cooling blood, blood stasis removing analgesic Function, be mainly used in febrile virulent maculae, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, closed dysmenorrhea, abdominal mass stomachache is fallen and flutters damage Wound, carbuncle swells sore.The radix paeoniae rubrathe mainly contains Paeoniflorin, and OP, benzoylpaeoniflorin, albiflorin, Paeoniflorin is not eaten without ketone Sub- acyl Paeoniflorin, lactiflorin, peony lactone etc., also contain cupreol, Daucosterol, infanticide acyl glucose, dextrorotation catechu Essence and volatile oil, wherein volatile oil mainly contain benzoic acid, paeonol and other alcohols and phenols component.Paeoniflorin content in root Height, entirely in root skin part.The modern pharmacological research explanation radix paeoniae rubrathe has spasmolysis；Step-down, increase blood flow；Analgesia, it is calm, anticonvulsion； Anti-inflammatory, antiulcer；The pharmacological action such as antibacterial, antipyretic.

The leaf of bamboo, Chinese medicine name.Sweet, light, cold in nature, the thoughts of returning home, lung, stomach, with clearing heat and relieving fidgetness, are promoted the production of body fluid, the effect of diuresis.With In pyreticosis polydipsia, pediatric epilepsy scared coughs inverse hematemesis, scanty drak urine, aphthous stomatitis tongue boil.《Book on Chinese herbal medicine is new again》：" cool heart invigorating the spleen, controls haematemesis, nose Blood, hearing-improing and eyesight improving.”

Peppermint：Taste is pungent, it is cool in nature；Return lung, Liver Channel.Dissipate wind-heat, refresh oneself, throat, promoting eruption, Xie Yu.Main wind-heat table card, mesh of having a headache Red, abscess of throat, measles without adequate eruption falls into rash itch, liver-depressed hypochondrium pain.《The southern regions of the Yunnan Province book on Chinese herbal medicine》Carry：" control all typhoid fever headaches, cholera vomit and diarrhoea, The all sores of carbuncle, subcutaneous ulcer, scabies, leprosy.Again：The all wind of refresh oneself on wild mint, only headache, dizziness, heating.Wind phlegm is gone, cough due to common cold, brain leakage is controlled The smelly tears of nose stream.Move back consumptive disease heating.”

The root bark of tree peony also known as moutan bark, Chinese medicine name.It is ranunculaceae peony dry root skin.Autumn excavates root, removes radicula, strips Root skin, dries.It is raw to use or fry use.《Compendium of Materia Medica》：" nourishing Yin and falling fire, solution spot poison, throat, diuresis stasis.Descendant be specially with Amur cork tree controls mutually fire, does not know that the work(of the root bark of tree peony more wins.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and preferably distinguishes it." bitter, pungent, it is micro- It is cold.The thoughts of returning home, liver and kidney channel, modern study, contained paeonol and its glucosides constituents in addition have antiinflammatory action；Moutan bark Methanolic extract has suppression Platelet；Paeonol has the central inhibitory actions such as calmness, cooling, antipyretic, analgesia, spasmolysis and resists Atherosclerosis, diuresis, antiulcer etc. are acted on.

New lotus leaf, also known as lotus flower stem, lotus stem.Nelumbonaceae Nelumbo perennial herb emergent aquactic plant, Gu claims lotus, lotus, lotus. Bitter but sweet flavor, mild-natured, the thoughts of returning home, Liver Channel, have functions that to clear away heart-fire relieving summer-heat, dissipate stasis of blood hemostasis, disappear wind clearing damp.Cure mainly hot summer weather polydipsia, children Frightened epilepsy, the inverse stupor of married woman's blood, gets injured by a fall spitting blood, irregular menstruation, uterine bleeding, wet sore mange.

Radix Glycyrrhizae:It is sweet, it is mild-natured；Returns spleen, stomach, the heart, lung channel.Invigorating middle warmer and replenishing QI, relieving spasm to stop pain moistens the lung and relieve the cough, purging intense heat and detonicating, adjusts With all medicines.Main burnout deficiency of food, the thin face of flesh is yellow, palpitation, suffer from abdominal pain loose stool, four limbs contraction, hysteria, cough and asthma, throat Swell and ache, ulcerative carbuncle swells and ache, infant fetal toxin, and medicine, food poisoning.《This warp》Carry：" the mansion fever and chills perverse trend of main the five internal organs six, hard muscles and bones is long Muscle, times power, metal-inflicted wound swells, removing toxic substances.”

Smallfruit Fig Aerial Root：Bitter, it is mild-natured；Return lung, spleen, kidney channel.Dissipate wind-heat, wind-damp dispelling, promoting blood circulation and stopping pain.Main flu, pertussis, measles is not Thoroughly, tonsillitis, conjunctivitis, treating rheumatic ostealgia, eruptive disease stomachache, protracted dysentery, stomachache, leukorrhea, eczema, pruritus vulvae, traumatic injury.Guangzhou portion Team《Conventional Chinese herbal medicine handbook》Carry：" relieving superficies by cooling, sweating promoting eruption.Influenza is controlled, is caught a cold, tonsillitis, eye conjunctivitis, malaria, hundred Day is coughed, measles without adequate eruption.”

Chushan lip-fern herb：Mildly bitter flavor, it is cold in nature；Return kidney, bladder, large intestine channel.Clearing heat and promoting diuresis, removing toxic substances.Main jaundice with damp-heat pathogen, diarrhea, dysentery is small Just puckery pain, abscess of throat, carbuncle swells boil, venomous snake bite.《Hunan medicine will》Carry：" antidiarrheal diuresis, clearing heat and detoxicating, styptic powder blood. Dysentery is controlled, bitterly, pin is soft powerless, fever with pantalgia for urine, had sore throat, snake bite, carbuncle furuncle ulcer.”

Giant knotweed is the dry rhizome and root of polygonaceae plant giant knotweed.Cold nature, mildly bitter flavor, Return liver, courage, lung channel, with expelling wind and removing dampness, Scattered stasis pain, it is relieving cough and reducing sputum, for treating joint pain, jaundice with damp-heat pathogen, Amenorrhea, abdominal mass, scald, injury from falling down, carbuncle swells Sore, coughing with a lot of sputum.Pharmacological action mainly shows as follows：(1) giant knotweed decocting liquid is to staphylococcus aureus, micrococcus catarrhalis, A type Or beta streptococcus, Escherichia coli, Pseudomonas aeruginosa have inhibitory action, high concentration giant knotweed decocting liquid also has killing to make to Leptospira With；(2) giant knotweed decocting liquid is to influenza Asia A type capital section 68-1 strain virus, orphan virus, herpes simplex virus, adenovirus type III, Poliomyelitis II types, enterovirus COxsackie A, B group, love can group, encephalitis B Jing Wei grinds No. 1, and one plant of herpe simplex is There is obvious inhibitory action.

Rattletop：Taste is pungent, sweet, cold nature；Return lung, spleen, large intestine, stomach.It is clearing heat and detoxicating, deliver promoting eruption, yang invigorating.When main Epidemic disease fiery poison, aphtha, pharyngalgia, macula, fever and chills of having a headache, carbuncle sore tumefacting virus, the sinking of qi of middle-jiao, splenasthenic diarrhea, weight under protracted dysentery, women's under band, Metrorrhagia.《Do not record》Carry：" dislike stomachache in master, when gas poison pestilence, fever and chills of having a headache, wind swells all poison, laryngalgia, aphtha.”

The alias of cape jasmine is Yellow Fructus Gardeniae, fructus gardeniae, Fructus Gardeniae, is the ripening fruits and root of madder wort cape jasmine, cold in nature, taste Hardship, the thoughts of returning home, lung, tri-jiao channel.The fruit of cape jasmine has purging intense heat relieving restlessness, and reducing fever and causing diuresis, effect of removing pattogenic heat from the blood and toxic material from the body is mainly used in pyreticosis It is vexed, jaundice urine is red, blood strangury and dry pain, blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles.The root of cape jasmine has purging intense heat and detonicating, heat-clearing profit It is wet, the function of cool blood dissipates the stasis of blood, for treating catarrhal jaundice, traumatic injury, acute toothache.Cape jasmine aqueous extract and alcohol extract Can promote choleresis, the effect of cholagogic, after intravenous injection crocin and crocetin sodium, choleresis increase.Cape jasmine Also there is the effect of calm step-down, antihypertensive effect is persistently and rapid.The unrestrained liquid of cape jasmine water is to oidium schoenleinii, groin table Various fungies such as dermatophytes, epidermophyton rubrum have inhibitory action, can kill Leptospira and blood fluke can be made to stop living It is dynamic.

Application method：After first affected part being cleared up with physiological saline, by uniform beach child Yu affected part of the invention, one time 0.5 ~1g, daily 2~3 times.

Toxicity test：The present invention is carried out into long term toxicity test to rat, continuous heavy dose of (100 times of child's dosage) fillings Stomach be administered, administration time is 90d, daily morning, noon and afternoon gavage 3 times, with animal administration before and after general performance, body weight, food ration, Hematology and Biochemical Indices In Serum, routine urinalysis, marrow classification, organ weights, organ coefficient are Testing index, and it is each to be aided with animal Organize the pathological examination of internal organs, the toxicity profile of overall merit medicine.The indices of result display rat are normal.Pathology Histological indications show that rat respectively organizes internal organs no abnormality seen.

Points for attention：The present invention is poisonous product, is disabled in oral cavity, and intraocular conjunctiva at cornea, is prohibited to this medicine allergy sufferers With pregnant woman uses with caution, and children should use under monitoring of being grown up.

In sum, the present invention has the positive effect that as a result of such scheme：The all medicine phases of the present invention are closed, tool Play the role of it is clearing heat and detoxicating, removing toxic substances eliminating dampness, eliminating dampness analgesic, promoting blood circulation and removing blood stasis, desinsection is antipruritic, remove necrosis and promote granulation, the activity in each medicinal material Composition mutually acts synergistically, so as to easily treat child's hand-foot-and-mouth disease, reaches the effect treated both principal and secondary aspect of disease.

Specific embodiment

Chinese medicine of child's hand-foot-and-mouth disease and preparation method thereof is treated to the present invention with reference to embodiment, is made furtherly It is bright.

Embodiment 1

A kind of Chinese medicine for treating child's hand-foot-and-mouth disease, is made up of the medicine of following weight portion：Vitamin B _ 80 part, vitamin C _ 80 Part, 80 parts of honeysuckle, 75 parts of caulis lonicerae, 75 parts of carrot, 60 parts of Radix Isatidis, 60 parts of centella, 50 parts of alkanet, the fruit of summer cypress 45 Part, 35 parts of the capsule of weeping forsythia, 35 parts of the coptis, 35 parts of favus skin, 35 parts of the radix paeoniae rubrathe, 25 parts of the leaf of bamboo, 25 parts of peppermint, 25 parts of the root bark of tree peony, new lotus leaf 20 15 parts of part, 20 parts of Radix Glycyrrhizae, 10 parts of Smallfruit Fig Aerial Root, 10 parts of chushan lip-fern herb, 15 parts of giant knotweed, 15 parts of rattletop and cape jasmine.

The preparation method of the Chinese medicine for the treatment of child's hand-foot-and-mouth disease described above, comprises the steps of：

（1）By weight ratio, caulis lonicerae, alkanet, the fruit of summer cypress, Radix Glycyrrhizae, Smallfruit Fig Aerial Root, chushan lip-fern herb, peppermint, the root bark of tree peony are gone respectively It is miscellaneous, clean after, add the alcohol reflux 2 times that 12 times of weight concentrations of caulis lonicerae are 60%, returned in 90 ± 2 DEG C of water-baths twice Stream, the time of backflow is 4h for the first time, and the time of second backflow is 2h, merges extract solution, to adding caulis lonicerae in extract solution The activated carbon of 1.5 times of weight shakes 15min, and natural filtration obtains stream immersion liquid；

（2）Radix Isatidis, the capsule of weeping forsythia, the coptis, favus skin are put into container, giant knotweed, rattletop, cape jasmine that addition is soaked, add plate blue 5h is boiled in 10 times of weight distilled water immersion 5h of root, heating, and filtrate and filter residue is collected by filtration, to addition 8 times of weights of Radix Isatidis in filter residue 3h is boiled in amount distilled water heating, falls net filtration using nylon and collects filtrate, merges filtrate twice, obtains liquid；

（3）Juice is smash in mixing after the radix paeoniae rubrathe, the leaf of bamboo, new lotus leaf, centella, honeysuckle, carrot are cleaned respectively, and net is fallen using nylon Filtration Filtration removes the gred, and obtains juice；

（4）By vitamin B, vitamin C, step（1）Stream immersion liquid, step（2）Liquid and step（3）Juice mixing it is equal It is even, then by filling after homogenizer homogeneous, microwave disinfection, the condition of the homogenization is：Pressure is 13Mpa, temperature is 60 DEG C, the temperature of the microwave disinfection is 60 DEG C, the time is that 2h, frequency are that 2200MHz, power are 6kw, obtains final product the treatment child The Chinese medicine of hand-foot-and-mouth disease.

Embodiment 2

A kind of Chinese medicine for treating child's hand-foot-and-mouth disease, is made up of the medicine of following weight portion：30 parts of vitamin B_1, vitamin C _ 130 parts, 100 parts of honeysuckle, 100 parts of caulis lonicerae, 100 parts of carrot, 90 parts of Radix Isatidis, 90 parts of centella, 85 parts of alkanet, It is 60 parts of skin, 50 parts of the capsule of weeping forsythia, 50 parts of the coptis, 50 parts of favus skin, 50 parts of the radix paeoniae rubrathe, 50 parts of the leaf of bamboo, 50 parts of peppermint, 50 parts of the root bark of tree peony, fresh 35 parts of 35 parts of lotus leaf, 35 parts of Radix Glycyrrhizae, 25 parts of Smallfruit Fig Aerial Root, 25 parts of chushan lip-fern herb, 35 parts of giant knotweed, 35 parts of rattletop and cape jasmine.

（1）By weight ratio, caulis lonicerae, alkanet, the fruit of summer cypress, Radix Glycyrrhizae, Smallfruit Fig Aerial Root, chushan lip-fern herb, peppermint, the root bark of tree peony are gone respectively It is miscellaneous, clean after, add the alcohol reflux 2 times that 16 times of weight concentrations of caulis lonicerae are 75%, returned in 90 ± 2 DEG C of water-baths twice Stream, the time of backflow is 5h for the first time, and the time of second backflow is 3h, merges extract solution, to adding caulis lonicerae in extract solution The activated carbon of 3.0 times of weight shakes 20min, and natural filtration obtains stream immersion liquid；

（2）Radix Isatidis, the capsule of weeping forsythia, the coptis, favus skin are put into container, giant knotweed, rattletop, cape jasmine that addition is soaked, add plate blue 6h is boiled in 15 times of weight distilled water immersion 7h of root, heating, and filtrate and filter residue is collected by filtration, to addition 10 times of weights of Radix Isatidis in filter residue 4h is boiled in amount distilled water heating, falls net filtration using nylon and collects filtrate, merges filtrate twice, obtains liquid；

（4）By vitamin B, vitamin C, step（1）Stream immersion liquid, step（2）Liquid and step（3）Juice mixing it is equal It is even, then by filling after homogenizer homogeneous, microwave disinfection, the condition of the homogenization is：Pressure is 17Mpa, temperature is 70 DEG C, the temperature of the microwave disinfection is 65 DEG C, the time is that 3h, frequency are that 2500MHz, power are 10kw, obtains final product the treatment small The Chinese medicine of child's hand-foot-and-mouth disease.

Embodiment 3

A kind of Chinese medicine for treating child's hand-foot-and-mouth disease, is made up of the medicine of following weight portion：Vitamin B _ 95 part, vitamin C _ 95 Part, 85 parts of honeysuckle, 85 parts of caulis lonicerae, 85 parts of carrot, 70 parts of Radix Isatidis, 70 parts of centella, 65 parts of alkanet, the fruit of summer cypress 50 Part, 40 parts of the capsule of weeping forsythia, 40 parts of the coptis, 40 parts of favus skin, 40 parts of the radix paeoniae rubrathe, 35 parts of the leaf of bamboo, 35 parts of peppermint, 35 parts of the root bark of tree peony, new lotus leaf 25 20 parts of part, 25 parts of Radix Glycyrrhizae, 15 parts of Smallfruit Fig Aerial Root, 15 parts of chushan lip-fern herb, 20 parts of giant knotweed, 20 parts of rattletop and cape jasmine.

（1）By weight ratio, caulis lonicerae, alkanet, the fruit of summer cypress, Radix Glycyrrhizae, Smallfruit Fig Aerial Root, chushan lip-fern herb, peppermint, the root bark of tree peony are gone respectively It is miscellaneous, clean after, add the alcohol reflux 2 times that 13 times of weight concentrations of caulis lonicerae are 65%, returned in 90 ± 2 DEG C of water-baths twice Stream, the time of backflow is 4.2h for the first time, and second time of backflow is 2.3h, merges extract solution, is born to being added in extract solution The activated carbon of 2.0 times of weight of winter rattan shakes 16min, and natural filtration obtains stream immersion liquid；

（2）Radix Isatidis, the capsule of weeping forsythia, the coptis, favus skin are put into container, giant knotweed, rattletop, cape jasmine that addition is soaked, add plate blue 5.2h is boiled in 11 times of weight distilled water immersion 5.5h of root, heating, and filtrate and filter residue is collected by filtration, to adding Radix Isatidis in filter residue 3.3h is boiled in 8.5 times of weight distilled water heating, falls net filtration using nylon and collects filtrate, merges filtrate twice, obtains liquid；

（4）By vitamin B, vitamin C, step（1）Stream immersion liquid, step（2）Liquid and step（3）Juice mixing it is equal It is even, then by filling after homogenizer homogeneous, microwave disinfection, the condition of the homogenization is：Pressure is 14Mpa, temperature is 63 DEG C, the temperature of the microwave disinfection is 61 DEG C, the time is that 2.3h, frequency are that 2300MHz, power are 7kw, obtains final product the treatment small The Chinese medicine of child's hand-foot-and-mouth disease.

Embodiment 4

A kind of Chinese medicine for treating child's hand-foot-and-mouth disease, is made up of the medicine of following weight portion：15 parts of vitamin B_1, vitamin C _ 115 parts, 95 parts of honeysuckle, 90 parts of caulis lonicerae, 90 parts of carrot, 80 parts of Radix Isatidis, 80 parts of centella, 70 parts of alkanet, the fruit of summer cypress 55 parts, 45 parts of the capsule of weeping forsythia, 45 parts of the coptis, 45 parts of favus skin, 45 parts of the radix paeoniae rubrathe, 40 parts of the leaf of bamboo, 40 parts of peppermint, 40 parts of the root bark of tree peony, new lotus leaf 30 parts of 30 parts, 30 parts of Radix Glycyrrhizae, 20 parts of Smallfruit Fig Aerial Root, 20 parts of chushan lip-fern herb, 30 parts of giant knotweed, 30 parts of rattletop and cape jasmine.

（1）By weight ratio, caulis lonicerae, alkanet, the fruit of summer cypress, Radix Glycyrrhizae, Smallfruit Fig Aerial Root, chushan lip-fern herb, peppermint, the root bark of tree peony are gone respectively It is miscellaneous, clean after, add the alcohol reflux 2 times that 15 times of weight concentrations of caulis lonicerae are 70%, returned in 90 ± 2 DEG C of water-baths twice Stream, the time of backflow is 4.8h for the first time, and second time of backflow is 2.8h, merges extract solution, is born to being added in extract solution The activated carbon of 2.5 times of weight of winter rattan shakes 19min, and natural filtration obtains stream immersion liquid；

（2）Radix Isatidis, the capsule of weeping forsythia, the coptis, favus skin are put into container, giant knotweed, rattletop, cape jasmine that addition is soaked, add plate blue 5.8h is boiled in 14 times of weight distilled water immersion 6.5h of root, heating, and filtrate and filter residue is collected by filtration, to adding Radix Isatidis in filter residue 3.7h is boiled in 9.5 times of weight distilled water heating, falls net filtration using nylon and collects filtrate, merges filtrate twice, obtains liquid；

（4）By vitamin B, vitamin C, step（1）Stream immersion liquid, step（2）Liquid and step（3）Juice mixing it is equal It is even, then by filling after homogenizer homogeneous, microwave disinfection, the condition of the homogenization is：Pressure is 16Mpa, temperature is 68 DEG C, the temperature of the microwave disinfection is 64 DEG C, the time is that 2.8h, frequency are that 2400MHz, power are 9kw, obtains final product the treatment small The Chinese medicine of child's hand-foot-and-mouth disease.

Embodiment 5

A kind of Chinese medicine for treating child's hand-foot-and-mouth disease, is made up of the medicine of following weight portion：05 part of vitamin B_1, vitamin C _ 105 parts, 90 parts of honeysuckle, 87 parts of caulis lonicerae, 88 parts of carrot, 75 parts of Radix Isatidis, 75 parts of centella, 67 parts of alkanet, the fruit of summer cypress 53 parts, 42 parts of the capsule of weeping forsythia, 43 parts of the coptis, 43 parts of favus skin, 43 parts of the radix paeoniae rubrathe, 37 parts of the leaf of bamboo, 37 parts of peppermint, 38 parts of the root bark of tree peony, new lotus leaf 25 parts of 28 parts, 27 parts of Radix Glycyrrhizae, 17 parts of Smallfruit Fig Aerial Root, 18 parts of chushan lip-fern herb, 25 parts of giant knotweed, 25 parts of rattletop and cape jasmine.

（1）By weight ratio, caulis lonicerae, alkanet, the fruit of summer cypress, Radix Glycyrrhizae, Smallfruit Fig Aerial Root, chushan lip-fern herb, peppermint, the root bark of tree peony are gone respectively It is miscellaneous, clean after, add the alcohol reflux 2 times that 14 times of weight concentrations of caulis lonicerae are 68%, returned in 90 ± 2 DEG C of water-baths twice Stream, the time of backflow is 4.5h for the first time, and second time of backflow is 2.5h, merges extract solution, is born to being added in extract solution The activated carbon of 2.3 times of weight of winter rattan shakes 17min, and natural filtration obtains stream immersion liquid；

（2）Radix Isatidis, the capsule of weeping forsythia, the coptis, favus skin are put into container, giant knotweed, rattletop, cape jasmine that addition is soaked, add plate blue 5.5h is boiled in 13 times of weight distilled water immersion 6h of root, heating, and filtrate and filter residue is collected by filtration, to 9 times of Radix Isatidis of addition in filter residue 3.5h is boiled in the heating of weight distilled water, falls net filtration using nylon and collects filtrate, merges filtrate twice, obtains liquid；

（4）By vitamin B, vitamin C, step（1）Stream immersion liquid, step（2）Liquid and step（3）Juice mixing it is equal It is even, then by filling after homogenizer homogeneous, microwave disinfection, the condition of the homogenization is：Pressure is 15Mpa, temperature is 65 DEG C, the temperature of the microwave disinfection is 62 DEG C, the time is that 2.5h, frequency are that 2350MHz, power are 8kw, obtains final product the treatment small The Chinese medicine of child's hand-foot-and-mouth disease.

In sum, all medicine phases of the invention are closed, with it is clearing heat and detoxicating, removing toxic substances eliminating dampness, eliminating dampness analgesic, promoting blood circulation and removing blood stasis, desinsection Effect that is antipruritic, removing necrosis and promoting granulation, the active component in each medicinal material mutually acts synergistically, so that child's hand-foot-and-mouth disease is easily treated, Reach the effect treated both principal and secondary aspect of disease.

The preferred embodiment of invention is the foregoing is only, is not intended to limit the invention, it is all in spirit of the invention Within principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.

Claims

1. a kind of Chinese medicine for treating child's hand-foot-and-mouth disease, it is characterised in that be made up of the medicine of following weight portion：Vitamin B _ 80 ~130 parts, vitamin C _ 80~130 part, 80~100 parts of honeysuckle, 75~100 parts of caulis lonicerae, 75~100 parts of carrot, plate it is blue 60~90 parts of root, 60~90 parts of centella, 50~85 parts of alkanet, 45~60 parts of the fruit of summer cypress, 35~50 parts of the capsule of weeping forsythia, the coptis 35~ 50 parts, 35~50 parts of favus skin, 35~50 parts of the radix paeoniae rubrathe, 25~50 parts of the leaf of bamboo, 25~50 parts of peppermint, 25~50 parts of the root bark of tree peony, fresh lotus 20~35 parts of leaf, 20~35 parts of Radix Glycyrrhizae, 10~25 parts of Smallfruit Fig Aerial Root, 10~25 parts of chushan lip-fern herb, 15~35 parts of giant knotweed, 15~35 parts of rattletop And 15~35 parts of cape jasmine.

2. it is according to claim 1 treatment child's hand-foot-and-mouth disease Chinese medicine, it is characterised in that by the medicine of following weight portion It is made：Vitamin B _ 95~115 part, vitamin C _ 95~115 part, 85~95 parts of honeysuckle, 85~90 parts of caulis lonicerae, carrot 85~90 parts, 70~80 parts of Radix Isatidis, 70~80 parts of centella, 65~70 parts of alkanet, 50~55 parts of the fruit of summer cypress, the capsule of weeping forsythia 40~ 45 parts, 40~45 parts of the coptis, 40~45 parts of favus skin, 40~45 parts of the radix paeoniae rubrathe, 35~40 parts of the leaf of bamboo, 35~40 parts of peppermint, the root bark of tree peony 35~40 parts, 25~30 parts of new lotus leaf, 25~30 parts of Radix Glycyrrhizae, 15~20 parts of Smallfruit Fig Aerial Root, 15~20 parts of chushan lip-fern herb, giant knotweed 20~30 20~30 parts of part, 20~30 parts of rattletop and cape jasmine.

3. it is according to claim 1 treatment child's hand-foot-and-mouth disease Chinese medicine, it is characterised in that by the medicine of following weight portion It is made：05 part of vitamin B_1, vitamin C _ 105 part, 90 parts of honeysuckle, 87 parts of caulis lonicerae, 88 parts of carrot, 75 parts of Radix Isatidis, 75 parts of centella, 67 parts of alkanet, 53 parts of the fruit of summer cypress, 42 parts of the capsule of weeping forsythia, 43 parts of the coptis, 43 parts of favus skin, 43 parts of the radix paeoniae rubrathe, the leaf of bamboo 37 Part, 37 parts of peppermint, 38 parts of the root bark of tree peony, 28 parts of new lotus leaf, 27 parts of Radix Glycyrrhizae, 17 parts of Smallfruit Fig Aerial Root, 18 parts of chushan lip-fern herb, 25 parts of giant knotweed, rattletop 25 25 parts of part and cape jasmine.

4. the preparation method of the Chinese medicine of the treatment child's hand-foot-and-mouth disease according to any one of claims 1 to 3, its feature exists In comprising the steps of：

5. it is according to claim 4 treatment child's hand-foot-and-mouth disease Chinese medicine preparation method, it is characterised in that：In step （2）And step（3）, the filter type that the filtering is used is that nylon falls net filtration.

6. it is according to claim 4 treatment child's hand-foot-and-mouth disease Chinese medicine preparation method, it is characterised in that：In step （4）, the condition of the homogenization is：Pressure is 13~17Mpa, and temperature is 60~70 DEG C；The temperature of the microwave disinfection is 60~65 DEG C, the time is 2~3h, and frequency is 2200~2500MHz, and power is 6~10kw.