CN103127371A - Chinese medicament for treating hand-foot-and-mouth diseases and preparation method thereof - Google Patents

Chinese medicament for treating hand-foot-and-mouth diseases and preparation method thereof Download PDF

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CN103127371A
CN103127371A CN2013100737475A CN201310073747A CN103127371A CN 103127371 A CN103127371 A CN 103127371A CN 2013100737475 A CN2013100737475 A CN 2013100737475A CN 201310073747 A CN201310073747 A CN 201310073747A CN 103127371 A CN103127371 A CN 103127371A
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李志荃
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李志荃
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Abstract

The invention relates to a Chinese medicament for treating hand-foot-and-mouth diseases, and belongs to the technical field of medicaments. The Chinese medicament is prepared into a decoction from the following raw materials: 3 to 10 g of licorice, 3 to 10 g of folium isatidis, 5 to 15 g of isatis root, 1 g of coptis, 3 to 10 g of tee tree root, 3 to 10 g of bupleurum, 3 to 10 g of dandelion, 3 to 10 g of mint, 3 to 10 g of Chinese violet, 5 to 10 g of dried rehmannia root, 5 to 10 g of honeysuckle, 5 to 10 g of weeping forsythia, 5 to 10 g of pseudostellaria heterophylla, 5 to 10 g of root of red-rooted salvia, 5 to 10 g of honeysuckle stem, 3 to 5 g of phellodendron, 3 to 6 g of gardenia, 3 to 10 g of figwort root, and 3 to 5 g of big fritillaria. Based on the cognition and the treatment principle of the pathogenesis of the hand-foot-and-mouth diseases, the Chinese medicament is prepared by using the traditional Chinese medicinal materials as raw materials through clinical test and repeated verification; and the Chinese medicament emphasizes heat clearing, detoxification and dehumidification, simultaneously proposes tonification and purgation in combination, qi tonification, yin nourishment, heat clearing and collateral dredging, accords with the theory of the traditional Chinese medicine, avoids the side response of unidirectional action of the western medical therapy and does not have toxic or side effect, the effective rate is 98 percent, and the cure rate is over 95 percent.

Description

A kind of Chinese medicine for the treatment of hand-foot-mouth disease and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of hand-foot-mouth disease and preparation method thereof, belong to medical technical field.
Background technology
Hand-foot-mouth disease is a kind of common infectious disease that is caused by enterovirus infection, multiplely be born in child below 5 years old, can occur generating heat and the herpes at the position such as hands, foot, oral cavity, the minority infant can cause the complication such as myocarditis, pulmonary edema, AME, if indivedual children with serious disease PD are fast, can cause death.This disease forms ulcer as main clinic symptoms after hands, foot and oral mucosa herpes or ulceration.
Because hand-foot-mouth disease patient with severe symptoms early clinical manifestation is not true to type, easily ignore when head examines, and disease progression is violent, in case breathing, the circulation complication such as pulmonary edema, pneumorrhagia occur, bring great difficulty to treatment, but even interior death of short time of infant.Doctor trained in Western medicine is commonly used the Drug therapys such as glucocorticoid, immunoglobulin, vasoactive drug, characterizes but these medicines are treatment mostly, use these medicines after the children with serious disease mortality rate still higher.The traditional Chinese medical science thinks that hand-foot-mouth disease is the acute infectious disease that causes due to exopathogen, according to the primary disease Characteristics of Syndromes, belong to the traditional Chinese medical science " epidemic febrile disease " category, therefore, according to the therapeutic principle of traditional Chinese medicine of " epidemic febrile disease ", it is very essential utilizing a kind of Chinese medicine of unique advantage invention of heat-clearing and detoxifying herb to treat hand-foot-mouth disease.
Summary of the invention
One of purpose of the present invention is, a kind of Chinese medicine for the treatment of hand-foot-mouth disease is provided, and solves above technical problem.
For addressing the above problem, the technical solution adopted in the present invention is:
A kind of Chinese medicine for the treatment of hand-foot-mouth disease is characterized in that: it is the decoction of being made by following composition of raw materials: Radix Glycyrrhizae 3-10g, Folium Isatidis 3-10g, Radix Isatidis 5-15g, Rhizoma Coptidis 1g, Radix Camelliae sinensis 3-10g, Radix Bupleuri 3-10g, Herba Taraxaci 3-10g, Herba Menthae 3-10g, Herba Violae 3-10g, Radix Rehmanniae 5-10g, Flos Lonicerae 5-10g, Fructus Forsythiae 5-10g, Radix Pseudostellariae 5-10g, Radix Salviae Miltiorrhizae 5-10g, Caulis Lonicerae 5-10g, Cortex Phellodendri 3-5g, Fructus Gardeniae 3-6g, Radix Scrophulariae 3-10g, Bulbus Fritillariae Thunbergii 3-5g.
Say further: the Chinese medicine of described treatment hand-foot-mouth disease is the decoction of being made by following composition of raw materials: Radix Glycyrrhizae 7g, Folium Isatidis 7g, Radix Isatidis 10g, Rhizoma Coptidis 1g, Radix Camelliae sinensis 7g, Radix Bupleuri 7g, Herba Taraxaci 7g, Herba Menthae 7g, Herba Violae 7g, Radix Rehmanniae 8g, Flos Lonicerae 8g, Fructus Forsythiae 8g, Radix Pseudostellariae 8g, Radix Salviae Miltiorrhizae 8g, Caulis Lonicerae 8g, Cortex Phellodendri 4g, Fructus Gardeniae 5g, Radix Scrophulariae 8g, Bulbus Fritillariae Thunbergii 4g.
Another object of the present invention is to, a kind of preparation method of above-mentioned treatment hand-foot-mouth disease Chinese medicine is provided, comprise the steps:
1, according to after formula weighing good all raw material of Chinese medicine, all medicines are put into marmite, add water by the 1:3 of medicine total amount, slow fire boiling was boiled rear 15-20 minute, the extraction supernatant; 1:1.5 by the medicine total amount adds water again, and slow fire boiling was boiled rear 15-20 minute, extracts supernatant;
2, bottling: packing into after the supernatant mixing with extracted twice seals in the bottle through sterilization;
3, sterilization: the disinfecting container that the bottle that medicinal liquid will be housed is put into high temperature 〉=100 ℃ carries out disinfection, and gets product.
The property of medicine, the pharmacology of the Chinese medicine that uses in the formula of medicine of the present invention are as follows:
Radix Glycyrrhizae: sweet in the mouth, property is flat; GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Folium Isatidis: bitter in the mouth, cold in nature; Enter liver, the heart, stomach warp.Function cures mainly: heat clearing away, detoxifcation, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst.
Radix Isatidis: bitter in the mouth, cold in nature, nontoxic; Return liver, stomach warp.Has heat clearing away, detoxifcation, removing heat from blood, the effect of sore-throat relieving.Cure mainly: maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever.
Rhizoma Coptidis: bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache is quenched one's thirst, the carbuncle furuncle; External treatment eczema, eczema.
Radix Camelliae sinensis: bitter in the mouth, cool in nature; GUIXIN, kidney channel.The heart tonifying diuresis; Promoting blood flow to regulate menstruation; Heat-clearing and toxic substances removing.Cure mainly: heart disease; Edema; Sore swollen toxin; Aphtha.
Radix Bupleuri: bitter in the mouth, cold nature.Return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, and soothing the liver, yang invigorating.
Herba Taraxaci: sweet in the mouth, little hardship, cold in nature.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Herba Menthae: cool in nature, acrid in the mouth.Function: the irritation effect causes trachea to produce new secretion, and makes the mucus of stiff be easy to get rid of, therefore the effect of eliminating the phlegm, sterilizing is arranged; " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control all typhoid fever headaches, cholera is vomited and diarrhoea, carbuncle, cellulitis, scabies, insane all skin ulcers.Again: all wind of refresh oneself on wild mint, only headache, dizzy, heating.
Herba Violae: bitter in the mouth, suffering, cold in nature, nontoxic; GUIXIN, Liver Channel.Function cures mainly: can be used as medicine, and its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, removing heat from blood detumescence.
Radix Rehmanniae: sweet in the mouth, hardship, cold in nature, function cures mainly: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting are used for the warm febrile disease blood of joining the army, fever of the body xerostomia, crimson tongue or the symptom such as red.
Flos Lonicerae: sweet in the mouth, cold in nature.Function: heat clearing away, detoxifcation, antiinflammatory, antibiotic effect are arranged.Compendium of Material Medica is carried " Flos Lonicerae is good at removing toxic substances, therefore control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, and toxic-heat and blood stasis, the diseases such as carbuncle and ulcer also are used for anemopyretic cold, the diseases such as bronchitis.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate the effect such as immunity.
Fructus Forsythiae: bitter in the mouth, cold nature.Function cures mainly: heat-clearing and toxic substances removing, and dispersing swelling and dissipating binds, dispelling wind and heat pathogens has the title of " persons particularly liable to develop skin infection's panacea ".
Radix Pseudostellariae: sweet in the mouth, little hardship, slightly warm in nature; Enter the heart, spleen, lung meridian.Has the effect of mending strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Cure mainly: the cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, edema is quenched one's thirst, and spirit is tired.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.Function cures mainly: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Modern study has and improves microcirculation, antibiotic, the effect that promotes tissue repair.
Caulis Lonicerae: sweet in the mouth, cold in nature.Function cures mainly: heat-clearing and toxic substances removing, dispelling wind collateral dredging.Be used for the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, rheumatism pyretic arthralgia etc." detailed outline ": " control all rheumatism gas and all swelling and ache, carbuncle scabies moss, Fructus Myricae rubrae malignant boil, heat radiation detoxifcation." modern pharmacological research, have anti-inflammation, multiple intestinal bacteria and virus are had inhibitory action.
Cortex Phellodendri: bitter in the mouth, cold in nature; Return kidney, bladder, large intestine channel.Function with cure mainly: heat clearing and damp drying, eliminating fire and detoxication is except the hectic fever due to YIN-deficiency clearind deficient heat.Modern study has anti-inflammation, strengthens immune effect, and the encephalitis that hand-foot-mouth disease is caused has curative effect preferably.
Fructus Gardeniae: be heat removing and blood cooling medicine, function cures mainly: pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body are used for calentura vexed, aphtha of the mouth and tongue, sore swollen toxin ....
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature; Return lung, stomach, kidney channel.Function cures mainly: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.Modern study has antibacterial action." detailed outline ": nourishing YIN to lower pathogenic fire, separate the speckle poison, throat, diuresis stasis.
Bulbus Fritillariae Thunbergii: flavor is large bitter, cold in nature.Function cures mainly: removing heat-phlegm, powder detoxifcation.Control the cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.
The present invention is based on the pathogenetic understanding of hand-foot-mouth disease and Therapeutic Principle, use the traditional Chinese medicine of China to be raw material, and formulated by clinic tests and repeated verification, emphasize heat-clearing and toxic substances removing, dehumidifying, advocate simultaneously reinforcement and elimination in combination, supplementing QI and nourishing YIN, heat clearing away collateral dredging, meet the theory of Chinese medicine, avoided the side reaction of western medicine therapy single effect, effective percentage is 98%, and cure rate is more than 95%, to have no side effect.
The specific embodiment
The present invention will be further described below in conjunction with specific embodiment.
Embodiment 1:
The Chinese medicine of the described treatment hand-foot-mouth disease of the present embodiment is the decoction of being made by following composition of raw materials: Radix Glycyrrhizae 3g, Folium Isatidis 3g, Radix Isatidis 5g, Rhizoma Coptidis 1g, Radix Camelliae sinensis 3g, Radix Bupleuri 3g, Herba Taraxaci 3g, Herba Menthae 3g, Herba Violae 3g, Radix Rehmanniae 5g, Flos Lonicerae 5g, Fructus Forsythiae 5g, Radix Pseudostellariae 5g, Radix Salviae Miltiorrhizae 5g, Caulis Lonicerae 5g, Cortex Phellodendri 3g, Fructus Gardeniae 3g, Radix Scrophulariae 3g, Bulbus Fritillariae Thunbergii 3g.
Embodiment 2:
The Chinese medicine of the described treatment hand-foot-mouth disease of the present embodiment is the decoction of being made by following composition of raw materials: Radix Glycyrrhizae 10g, Folium Isatidis 10g, Radix Isatidis 15g, Rhizoma Coptidis 1g, Radix Camelliae sinensis 10g, Radix Bupleuri 10g, Herba Taraxaci 10g, Herba Menthae 10g, Herba Violae 10g, Radix Rehmanniae 10g, Flos Lonicerae 10g, Fructus Forsythiae 10g, Radix Pseudostellariae 10g, Radix Salviae Miltiorrhizae 10g, Caulis Lonicerae 10g, Cortex Phellodendri 5g, Fructus Gardeniae 6g, Radix Scrophulariae 10g, Bulbus Fritillariae Thunbergii 5g.
Embodiment 3:
The Chinese medicine of the described treatment hand-foot-mouth disease of the present embodiment is the decoction of being made by following composition of raw materials: Radix Glycyrrhizae 7g, Folium Isatidis 7g, Radix Isatidis 10g, Rhizoma Coptidis 1g, Radix Camelliae sinensis 7g, Radix Bupleuri 7g, Herba Taraxaci 7g, Herba Menthae 7g, Herba Violae 7g, Radix Rehmanniae 8g, Flos Lonicerae 8g, Fructus Forsythiae 8g, Radix Pseudostellariae 8g, Radix Salviae Miltiorrhizae 8g, Caulis Lonicerae 8g, Cortex Phellodendri 4g, Fructus Gardeniae 5g, Radix Scrophulariae 8g, Bulbus Fritillariae Thunbergii 4g.
The preparation method for the treatment of hand-foot-mouth disease Chinese medicine of the present invention comprises the steps:
1, according to after formula weighing good all raw material of Chinese medicine, all medicines are put into marmite, add water by the 1:3 of medicine total amount, slow fire boiling was boiled rear 15-20 minute, the extraction supernatant; 1:1.5 by the medicine total amount adds water again, and slow fire boiling was boiled rear 15-20 minute, extracts supernatant;
2, bottling: packing into after the supernatant mixing with extracted twice seals in the bottle through sterilization;
3, sterilization: the disinfecting container that the bottle that medicinal liquid will be housed is put into high temperature 〉=100 ℃ carries out disinfection, and gets product.
[clinical efficacy summary]:
One, we are extensive in clinical practice for many years, treat routine patients up to a hundred, and are evident in efficacy.
Two, diagnostic criteria: be 2~7 the incubation period of hand-foot-mouth disease, and the source of infection comprises patient and inapparent infection person.Acute onset, heating, herpes appears being dispersed in oral mucosa, and maculopapule, herpes appear in hands, foot and buttocks, around herpes, inflammatory blush can be arranged, and in bleb, liquid is less.Can be with symptoms such as cough, watery nasal discharge, inappetence.Some cases only shows as erythra or herpangina.How fully recovering within a week, severe patient can involve nervous system and breathing, blood circulation cause death.Patient's herpes liquid, stool are separable to enterovirus.
Three, administrated method: make decoction according to above-mentioned formula, every dose of 50-100ml divides and feeds for 3 times.Neonate 5-10 every day milliliter; February-1 year old baby, every day the 10-15 milliliter; 1-2 year baby, every day the 15-20 milliliter; 2-3 year child, every day the 20-30 milliliter; 3-4 year child, every day the 30-40 milliliter; 4-6 year juvenile, every day the 40-60 milliliter; Child 60-90 every day milliliter more than six years old.
Four, efficacy evaluation:
Cure: clinical symptoms disappears fully, and it is normal that lab testing recovers.
Take a turn for the better: clinical symptoms and sign are improved, and lab testing is substantially controlled.
Do not heal: clinical symptoms is without improving or increasing the weight of.
Five, therapeutic effect: treatment by Chinese herbs hand-foot-mouth disease of the present invention, cure rate is 95% by statistics, and effective percentage is more than 98%.
[case-data]:
Medical record 1:
King * *, Shouguang City, Shandong Province infant, 2 years old half.When medical, the disease symptom of this infant is sialorrhea, pharyngalgia, low grade fever, except above-mentioned symptom, infant palm, the back of the hand, instep, vola, visible a plurality of red pimple and the herpess that differ in size of buttocks, the part diabrosis, pharynx rear wall and oral mucosa are seen a plurality of point-like ulcer, are hand-foot-mouth disease after diagnosing.Take 1 dose, Chinese medicine of the present invention, heat is moved back, take 5 doses after state of an illness recovery from illness.
Medical record 2:
Woods * *, Shandong Province's Qingzhou City infant, 4 years old.When medical, the main disease symptom of this infant is low grade fever, micro evil wind, cough, nasal obstruction watery nasal discharge, and hand-foot skin, pars oralis pharyngis are seen a large amount of herpess, and local pruritus has nauseating, the symptom of having loose bowels, and is diagnosed as hand-foot-mouth disease.Take Chinese medicine of the present invention recovery from illness afterwards in 7 days.
Medical record 3:
Rhizoma Zingiberis Recens * *, Shouguang City, Shandong Province infant, 3 years old half.When medical, the main disease symptom of this infant for high heat, feel sick, oral cavity pain, dysphoria, night sleep peaceful, yellowish urine is red, a large amount of herpess appear in hand-foot skin, pars oralis pharyngis, the part diabrosis is diagnosed as hand-foot-mouth disease.Took effect in 2 days with Chinese medicine of the present invention, heating, the transference cure such as nauseating, irritated, after 6 days, herpes disappears fully, fully recovers.
Medical record 4:
Model * *, Changyue County, Shandong Province infant, 5 years old.When medical, maculopapule, herpes appear in the hands of this infant, foot and buttocks, and quality is harder, and blush is arranged on every side, with moderate heating, headache, weak symptom, is diagnosed as hand-foot-mouth disease.Took effect in 1 day with Chinese medicine of the present invention, after 2 days, heating, headache, weak transference cure, recovery from illness in 7 days.
Medical record 5:
Song * *, Shouguang City, Shandong Province infant, 3 years old.When medical, this infant is positioned at tongue, pharynx rear wall and two buccals vesicle, and blush is arranged on every side, and the herpes ulceration, and hands, foot and buttocks have the kermesinus maculopapule, and with pharyngalgia, heating paresthesia, are diagnosed as hand-foot-mouth disease.Take Chinese medicine of the present invention and took effect in 2 days, recovery from illness in 6 days.

Claims (3)

1. Chinese medicine for the treatment of hand-foot-mouth disease, it is characterized in that: it is the decoction of being made by following composition of raw materials: Radix Glycyrrhizae 3-10g, Folium Isatidis 3-10g, Radix Isatidis 5-15g, Rhizoma Coptidis 1g, Radix Camelliae sinensis 3-10g, Radix Bupleuri 3-10g, Herba Taraxaci 3-10g, Herba Menthae 3-10g, Herba Violae 3-10g, Radix Rehmanniae 5-10g, Flos Lonicerae 5-10g, Fructus Forsythiae 5-10g, Radix Pseudostellariae 5-10g, Radix Salviae Miltiorrhizae 5-10g, Caulis Lonicerae 5-10g, Cortex Phellodendri 3-5g, Fructus Gardeniae 3-6g, Radix Scrophulariae 3-10g, Bulbus Fritillariae Thunbergii 3-5g.
2. treat according to claim 1 the Chinese medicine of hand-foot-mouth disease, it is characterized in that: it is the decoction of being made by following composition of raw materials: Radix Glycyrrhizae 7g, Folium Isatidis 7g, Radix Isatidis 10g, Rhizoma Coptidis 1g, Radix Camelliae sinensis 7g, Radix Bupleuri 7g, Herba Taraxaci 7g, Herba Menthae 7g, Herba Violae 7g, Radix Rehmanniae 8g, Flos Lonicerae 8g, Fructus Forsythiae 8g, Radix Pseudostellariae 8g, Radix Salviae Miltiorrhizae 8g, Caulis Lonicerae 8g, Cortex Phellodendri 4g, Fructus Gardeniae 5g, Radix Scrophulariae 8g, Bulbus Fritillariae Thunbergii 4g.
3. treat as claimed in claim 1 the preparation method of hand-foot-mouth disease Chinese medicine, it is characterized in that: comprise the steps:
(1) according to after formula weighing good all raw material of Chinese medicine, all medicines are put into marmite, add hydrology fire by the 1:3 of medicine total amount and decoct, boiled rear 15-20 minute, the extraction supernatant; 1:1.5 by the medicine total amount adds slow fire boiling again, boils rear 15-20 minute, extracts supernatant;
(2) bottling: packing into after the supernatant mixing with extracted twice seals in the bottle through sterilization;
(3) sterilization: the disinfecting container that the bottle that medicinal liquid will be housed is put into high temperature 〉=100 ℃ carries out disinfection, and gets product.
CN201310073747.5A 2013-03-08 2013-03-08 Chinese medicament for treating hand-foot-and-mouth diseases and preparation method thereof Expired - Fee Related CN103127371B (en)

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CN103566079A (en) * 2013-11-19 2014-02-12 周俊英 Medicament for treating infantile hand-foot-mouth disease
CN104189611A (en) * 2014-09-22 2014-12-10 刘丽霞 Traditional Chinese medicine composition for treating hand-foot-and-mouth disease
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103566079A (en) * 2013-11-19 2014-02-12 周俊英 Medicament for treating infantile hand-foot-mouth disease
CN103566079B (en) * 2013-11-19 2015-07-01 周俊英 Medicament for treating infantile hand-foot-mouth disease
CN104189611A (en) * 2014-09-22 2014-12-10 刘丽霞 Traditional Chinese medicine composition for treating hand-foot-and-mouth disease
CN104306494A (en) * 2014-11-28 2015-01-28 胡开明 Traditional Chinese medicine gargle used for treating children hand-foot-mouth disease
CN104758773A (en) * 2015-04-03 2015-07-08 王建芳 Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease
CN105012729A (en) * 2015-07-09 2015-11-04 杜仁波 Traditional Chinese medicine composition for treating hand-foot-and-mouth disease
CN105998402A (en) * 2016-06-20 2016-10-12 刘同祥 Pharmaceutical preparation for treating hand-foot-mouth disease and application of pharmaceutical preparation
CN106309455A (en) * 2016-08-16 2017-01-11 江苏康缘药业股份有限公司 Application of peimisine
CN106309455B (en) * 2016-08-16 2019-02-05 江苏康缘药业股份有限公司 The purposes of Peimisine
CN106729007A (en) * 2016-11-21 2017-05-31 广西大学 Treat Chinese medicine of child's hand-foot-and-mouth disease and preparation method thereof

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