CN104707010A - Traditional Chinese medicinal composition for treating pneumonia and clearing away heat and toxic materials and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating pneumonia and clearing away heat and toxic materials and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating pneumonia and clearing away heat and toxic materials. The traditional Chinese medicinal composition for treating pneumonia and clearing away heat and toxic materials is prepared from the following main raw materials in parts by mass: 10-16 parts of gardenia, 14-18 parts of rhodiola rosea, 4-7 parts of raw gypsum, 8-16 parts of eurotia ceratoides, 12-18 parts of liquorice, 9-16 parts of hemipilia flabellata, 7-15 parts of white mulberry root-bark, 9-16 parts of veronicastrum herb, 10-19 parts of radix pseudostellariae, 8-15 parts of indigofera fortunei craib, 10-16 parts of wreath goldenrod, 7-14 parts of akebiaquinata, 10-14 parts of kerria japonica, 6-12 parts of indigo naturalis, 11-15 parts of lantern plant calyx, 12-16 parts of tabasheer and 5-13 parts of false aloe. The traditional Chinese medicinal composition for treating pneumonia and clearing away heat and toxic materials has the effects of clearing away heat and toxic materials, facilitating lungs and relaxing bowels, clearing lung and eliminating phlegm, dispelling wind and heat as well as moistening lung to arrest cough and has an obvious curative effect on pneumonia.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly a kind of heat-clearing and detoxifying herb compositions and preparation method for the treatment of pneumonia.
Background technology
Pneumonia is a kind of common multiple infectious disease, and refer to last air flue eventually, the inflammation of alveolar and interstitial lung, can by disease microorganisms, chemical factors, immunologic injury, allergy and drug-induced.Bacterial pneumonia is modal pneumonia, is also one of modal infectious disease, and daily said pneumonia mainly refers to the pneumonia that bacterial infection causes.Clinical manifestation mainly contains fever, cough, excessive phlegm, chest pain etc., and serious symptom person breathes hurriedly, dyspnea, can threat to life.The World Health Organization (WHO) points out in a report recently, and cause in morbidity and murderous disease in the whole world, lower respiratory infection (mainly pneumonia) is listed in the 3rd high harm disease.
Pathogeny: 1. bacterial pneumonia: be mainly edematous fluid and serosity precipitation in early days; Mid-term is that erythrocyte oozes out; There are a large amount of leukocyte and phagocyte aggregation in later stage, and lung tissue is suddenlyd change; Finally dissipate for pneumonia absorbs.In whole pathological process, do not have destruction or the necrosis of alveolar wall and other lung structures, after pneumonia dissipates, lung tissue can be recovered normal completely and not leave over fibrosis or emphysema.In S. aureus L-forms pneumonia, the bacteriogenic alcohol that solidifies can form outward protecting film with anti-cytophagous killing action at thalline, and the release of various enzyme can cause the necrosis of lung tissue and abscess to be formed.Pathological changes is invaded and or is worn out pleura and then can form empyema or pyopneumothorax.Pathological changes can form lung qi capsule when dissipating.Gram negative bacillus pneumonia mostly is bilateral bronchiolitis, and often have multiple gangrenosum acne cavity or abscess, some patients empyema can occur.Dissipate not exclusively normal, fibroplasia, residual suppuration stove and bronchiectasis can be caused.2. mycoplasma pneumonia: pulmonary lesion in the form of sheets or confluent bronchopneumonia or interstitial pneumonia, companion's acute bronchitis.Can a small amount of transudate be contained in alveolar, and focal atelectasis, pulmonary consolidation and emphysema can occur.Alveolar wall and to be separated with neutrophilic granulocyte and large mononuclear cell infiltrates.Bronchial mucosa cell can have downright bad and come off, and has neutrophil infiltration.Pleura can have Fibrin exudation and a small amount of sepage.3. bronchopneumonia: main based on alveolar inflammation, bronchial wall and alveolar spaces inflammatory lesion lighter.Alveolar capillary dilatation and congestion, alveolar wall edema, has a large amount of neutrophilic granulocyte, erythrocyte, cellulose transudate and antibacterial in alveolar.Inflammation is spread to adjacent tissue by passage between alveolar and bronchioles, and in scutellate focal inflammation, small lesion can merge expansion mutually.When bronchia, capillary bronchus are inflamed, tube chamber is narrower causes luminal part or total blockage, causes emphysema or pulmonary atelectasis.During viral pneumonia, bronchus and capillary bronchial wall and alveolar septum all have edema, have mucus and destroyed cell accumulation in tube wall.Alveolar and alveolar conduit, the visible monocyte infiltration of interstitial.
At present, the medicine for the treatment of pneumonia is a lot, publication number CN 103028035 A(application number 201110296036.5) patent document discloses a kind of Chinese medicine composition for the treatment of pneumonia, be made up of six kinds of medicines: 10 grams, Radix Glycyrrhizae, Herba Houttuyniae 3 grams, Herba Menthae 15 grams, Flos Lonicerae 2 grams, Radix Ophiopogonis 5 grams, Borneolum Syntheticum 2 grams.Publication number CN 103877517 A(application number 201410141298.8) patent document discloses a kind of Chinese medicine for the treatment of pneumonia, be made up of the raw material of following weight parts proportioning: Herba Taraxaci 5, Herba Patriniae 8, Herba Scutellariae Barbatae 10, Rhizoma Polygoni Cuspidati 12, Flos Chrysanthemi 7, Herba Lysimachiae 9, Fructus Forsythiae 6, Fructus Gardeniae 4, Radix Platycodonis 7, the Radix Paeoniae Alba 9, Ramulus Uncariae Cum Uncis 11, Rhizoma Cimicifugae 12, Bombyx Batryticatus 10, Rhizoma Et Radix Notopterygii 8, Radix Saposhnikoviae 4, Scorpio 5, Ramulus Cinnamomi 9, Fructus Corni 12, Radix Dipsaci 11, Radix Angelicae Pubescentis 10, Radix Angelicae Sinensis 8, Thallus Laminariae (Thallus Eckloniae) 6, Sargassum 4, Spica Prunellae 12, Radix Curcumae 10, Rhizoma Cyperi 11, Radix Ophiopogonis 7, the Radix Rehmanniae 9, Galla Chinensis 13, Fructus Aurantii Immaturus 14, Radix Achyranthis Bidentatae 16, Caulis Spatholobi 15, Radix Aconiti Lateralis Preparata 8, Periostracum Cicadae 7, Herba Asari 9, Rhizoma Chuanxiong 12, the Radix Angelicae Dahuricae 11, Massa Medicata Fermentata 5, Flos Carthami 12, Herba Agrimoniae 5, Semen Benincasae 7, Semen Cuscutae 8, Herba Taxilli 12, Radix Codonopsis 4, Radix Bupleuri 5, PINGDIMU 8.Publication number CN 103550717 A(application number 201310573860.X) patent document discloses a kind of Chinese medicine for the treatment of pneumonia, be made up of the raw material of following weight parts proportioning: Poria 5-9, Radix Glycyrrhizae 8-12, Semen Armeniacae Amarum 6-12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3-9, Pheretima 5-10, Radix Bupleuri 5-20, Pericarpium Citri Reticulatae 2-10, Herba Patriniae 6-10, Radix Pseudostellariae 7-15, Cortex Phellodendri 4-13, Herba Solani Nigri 4-9, Radix Curcumae 6-14, Radix Salviae Miltiorrhizae 5-15, Fructus Corni 4-15, Radix Angelicae Sinensis 6-15, Hirudo 5-14, Rhizoma Curculiginis 6-15, Semen Raphani 6-12, Herba Plantaginis 4-12, Rhizoma Chuanxiong 8-15, Herba Spirodelae 6-10, Radix Saposhnikoviae 6-15.
At present, doctor trained in Western medicine for the large multiplex antibiotic therapy of bacterial pneumonia, its instant effect, but more side effect can be produced; There is antiviral drugs viral pneumonia aspect except the pneumonia caused due to influenza virus, and other viral pneumonias all do not have active drug.Although some medicines have appearred in traditional Chinese medical science aspect, curative effect is also indefinite.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of heat-clearing and detoxifying herb compositions for the treatment of pneumonia, has heat-clearing and toxic substances removing, and lung qi dispersing is logical bows, and removing heat from the lung and dissipating phlegm, dispelling wind and heat pathogens, effect of nourishing the lung to arrest cough, has obvious curative effect to pneumonia.Another object of the present invention is just to provide the preparation method of the heat-clearing and detoxifying herb compositions of above-mentioned treatment pneumonia.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a heat-clearing and detoxifying herb compositions for pneumonia, take off the primary raw material stating weight proportion and be prepared from: Fructus Gardeniae 10-16 part; Radix Rhodiolae 14-18 part; Gypsum Fibrosum 4-7 part; If excellent Herba chenopodii 8-16 part; Radix Glycyrrhizae 12-18 part; Herba Hemipiliae Flabellatae 9-16 part; Cortex Mori 7-15 part; Fishing stalk 9-16 part; Radix Pseudostellariae 10-19 part; Indigofera fortunei Craib 8-15 part; Herba Cremanthodii plantaginei 10-16 part; Caulis Akebiae 7-14 part; Flos kerriae japonicae 10-14 part; Indigo Naturalis 6-12 part; Calyx seu Fructus physalis 11-15 part; Concretio Silicea Bambusae 12-16 part; Herba Saniculae lamelligerae 5-13 part.
Treat a heat-clearing and detoxifying herb compositions for pneumonia, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Fructus Gardeniae 12-14 part; Radix Rhodiolae 15-17 part; Gypsum Fibrosum 5-6 part; If excellent Herba chenopodii 11-13 part; Radix Glycyrrhizae 14-16 part; Herba Hemipiliae Flabellatae 11-14 part; Cortex Mori 10-12 part; Fishing stalk 11-14 part; Radix Pseudostellariae 13-16 part; Indigofera fortunei Craib 10-13 part; Herba Cremanthodii plantaginei 12-14 part; Caulis Akebiae 9-12 part; Flos kerriae japonicae 11-13 part; Indigo Naturalis 8-10 part; Calyx seu Fructus physalis 12-14 part; Concretio Silicea Bambusae 13-15 part; Herba Saniculae lamelligerae 8-10 part.
Treat a heat-clearing and detoxifying herb compositions for pneumonia, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from
:fructus Gardeniae 13 parts; Radix Rhodiolae 16 parts; Gypsum Fibrosum 5.5 parts; If excellent Herba chenopodii 12 parts; 15 parts, Radix Glycyrrhizae; Herba Hemipiliae Flabellatae 12 parts; Cortex Mori 11 parts; Fishing stalk 12 parts; Radix Pseudostellariae 15 parts; Indigofera fortunei Craib 12 parts; Herba Cremanthodii plantaginei 13 parts; Caulis Akebiae 11 parts; Flos kerriae japonicae 12 parts; Indigo Naturalis 9 parts; Calyx seu Fructus physalis 13 parts; Concretio Silicea Bambusae 14 parts; Herba Saniculae lamelligerae 9 parts.
Present invention also offers the preparation method heat-clearing and detoxifying herb compositions of above-mentioned treatment pneumonia being made pharmaceutically acceptable powder, decoction, pill, tablet and granule.
The preparation method of the heat-clearing and detoxifying herb compositions powder of described treatment pneumonia, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Indigo Naturalis, Calyx seu Fructus physalis, Concretio Silicea Bambusae and Herba Saniculae lamelligerae are dried, pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) by step (1)-(4) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
Instructions of taking: at every turn get 8-10g, is placed in tea bag, soaks, every day 2-3 time, 2 days courses for the treatment of by the warm waters of about 50 DEG C.
The preparation method of the heat-clearing and detoxifying herb compositions decoction of described treatment pneumonia, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 30-40 minute, add step (3) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 4-6 hour, filter, be concentrated into 1/2 of original volume, obtain decoction.
The preparation method of the heat-clearing and detoxifying herb compositions decoction of above-mentioned treatment pneumonia, the consumption of the preferred yellow wine of step (4) is the 15%-20% of Indigo Naturalis and Concretio Silicea Bambusae gross mass, and the consumption being more preferably yellow wine is 18% of Indigo Naturalis and Concretio Silicea Bambusae gross mass.
Instructions of taking: each 15-20ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 2 days courses for the treatment of.
The preparation method of the heat-clearing and detoxifying herb compositions pill of described treatment pneumonia, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 30-40 minute, add step (3) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 3-5 hour, filter, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
Instructions of taking: each 10-15 ball, every day 3 times, 2 days courses for the treatment of.
The preparation method of the heat-clearing and detoxifying herb composition tablet of described treatment pneumonia, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 30-40 minute, add step (3) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 3-5 hour, filter, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 2 days courses for the treatment of.
The preparation method of the heat-clearing and detoxifying herb composition granule of described treatment pneumonia, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 30-40 minute, add step (3) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 3-5 hour, filter, being concentrated into relative density is 1.10.-1.20(40 DEG C) thick paste, add simple syrup, mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
The preparation method of the heat-clearing and detoxifying herb composition granule of above-mentioned treatment pneumonia, the consumption of the preferred simple syrup of step (6) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
Instructions of taking: each 1 bag, every day 3 times, 2 days courses for the treatment of.
Technical advantage of the present invention is mainly reflected in:
1, the present invention adopts the preparation of pure natural medical material, and all meticulous compatibility forms, and drug effect is lastingly powerful, and quality of medicinal material is superior, safe and reliable, does not injure the intestines and stomach, can not produce drug dependence, have no side effect.
2, each raw material effect of the present invention is worked in coordination with, and all medicine compatibilities, have heat-clearing and toxic substances removing, and lung qi dispersing is logical bows, and removing heat from the lung and dissipating phlegm, dispelling wind and heat pathogens, effect of nourishing the lung to arrest cough, has obvious curative effect to pneumonia.
3, selected materials great majority of the present invention are Chinese medicine material, and medical material is easy to get, and cost is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat a heat-clearing and detoxifying herb compositions for pneumonia, take off the primary raw material stating weight proportion and be prepared from (getting 40g for every part): Fructus Gardeniae 10 parts; Radix Rhodiolae 14 parts; Gypsum Fibrosum 4 parts; If excellent Herba chenopodii 8 parts; 12 parts, Radix Glycyrrhizae; Herba Hemipiliae Flabellatae 9 parts; Cortex Mori 7 parts; Fishing stalk 9 parts; Radix Pseudostellariae 10 parts; Indigofera fortunei Craib 8 parts; Herba Cremanthodii plantaginei 10 parts; Caulis Akebiae 7 parts; Flos kerriae japonicae 10 parts; Indigo Naturalis 6 parts; Calyx seu Fructus physalis 11 parts; Concretio Silicea Bambusae 12 parts; Herba Saniculae lamelligerae 5 parts.
The preparation method of the heat-clearing and detoxifying herb compositions powder of above-mentioned treatment pneumonia, step is as follows:
(1) smashed by Gypsum Fibrosum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 35 minutes, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, dry, and porphyrize, crosses 140 mesh sieves;
(4) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Indigo Naturalis, Calyx seu Fructus physalis, Concretio Silicea Bambusae and Herba Saniculae lamelligerae are dried, pulverize, cross 140 mesh sieves;
(5) by step (1)-(4) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
Instructions of taking: at every turn get 10g, is placed in tea bag, soaks, every day 3 times, 2 days courses for the treatment of by the warm waters of about 50 DEG C.
embodiment 2treat a heat-clearing and detoxifying herb compositions for pneumonia, take off the primary raw material stating weight proportion and be prepared from (every part of 20g): Fructus Gardeniae 16 parts; Radix Rhodiolae 18 parts; Gypsum Fibrosum 7 parts; If excellent Herba chenopodii 16 parts; 18 parts, Radix Glycyrrhizae; Herba Hemipiliae Flabellatae 16 parts; Cortex Mori 15 parts; Fishing stalk 16 parts; Radix Pseudostellariae 19 parts; Indigofera fortunei Craib 15 parts; Herba Cremanthodii plantaginei 16 parts; Caulis Akebiae 14 parts; Flos kerriae japonicae 14 parts; Indigo Naturalis 12 parts; Calyx seu Fructus physalis 15 parts; Concretio Silicea Bambusae 16 parts; Herba Saniculae lamelligerae 13 parts.
The preparation method of the heat-clearing and detoxifying herb compositions decoction of above-mentioned treatment pneumonia, step is as follows:
(1) smashed by Gypsum Fibrosum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 35 minutes, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 3 hours, puts in tank, and airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, crosses 140 mesh sieves;
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 35 minutes, add step (3) gains, decoct twice, boil 35 minutes, twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 5 hours, filter, be concentrated into 1/2 of original volume, obtain decoction.
Instructions of taking: each 20ml, every day 3 times, 2 days courses for the treatment of.
model case oneopen XX, man, 12 years old, people from Zaozhuang City of Shandong Province.Occur cough after suffering from cold before one week, have expectorant, occur low grade fever, body temperature 37.8 DEG C, slightly pants, so remove examination in hospital, psychoreaction was poor at that time, and irritated, complexion is greyish white, and two pulmonary respiration sound is thick.Routine blood test: leukocyte 6.25*10
9/ L, neutrophilic granulocyte 31.5%, lymphocyte 70.6%, hemoglobin 97g/L, platelet 349*10
9/ L, tuberculin pure protein spreads out thing (PPD) (-); Color Sonography shows no obvious abnormalities, abdomen B ultrasonic no abnormality seen, and x-ray rabat shows: two lung marking are slightly many, fuzzy, band patch shape shade in the lung of bottom right.Be diagnosed as pneumonia, corresponding treatment is after 5 days, and body temperature is normal, but still cough is more than.
After taking 2 courses for the treatment of of heat-clearing and detoxifying herb compositions decoction (embodiment 2) of gained of the present invention treatment pneumonia, heat is moved back, and checks every inflammation index and is down to normally, and cough obviously alleviates, but two lung audible and slightly measure stridulate sound and fine rales.After continuing to take 2 courses for the treatment of, all malaise symptoms disappear, and reach clinical cure.Tracing observation is learnt without recurrence.
embodiment 3treat a heat-clearing and detoxifying herb compositions for pneumonia, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): Fructus Gardeniae 12 parts; Radix Rhodiolae 15 parts; Gypsum Fibrosum 5 parts; If excellent Herba chenopodii 11 parts; 14 parts, Radix Glycyrrhizae; Herba Hemipiliae Flabellatae 11 parts; Cortex Mori 10 parts; Fishing stalk 11 parts; Radix Pseudostellariae 13 parts; Indigofera fortunei Craib 10 parts; Herba Cremanthodii plantaginei 12 parts; Caulis Akebiae 9 parts; Flos kerriae japonicae 11 parts; Indigo Naturalis 8 parts; Calyx seu Fructus physalis 12 parts; Concretio Silicea Bambusae 13 parts; Herba Saniculae lamelligerae 8 parts.
The preparation method of the heat-clearing and detoxifying herb compositions pill of above-mentioned treatment pneumonia, step is as follows:
(1) smashed by Gypsum Fibrosum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 35 minutes, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 3 hours, puts in tank, and airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, crosses 140 mesh sieves;
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 35 minutes, add step (3) gains, decoct twice, boil 35 minutes, twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 4 hours, filter, be condensed into the thick paste that relative density is 1.20, make the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 2 days courses for the treatment of.
embodiment 4treat a heat-clearing and detoxifying herb compositions for pneumonia, take off the primary raw material stating weight proportion and be prepared from (getting 25g for every part): Fructus Gardeniae 14 parts; Radix Rhodiolae 17 parts; Gypsum Fibrosum 6 parts; If excellent Herba chenopodii 13 parts; 16 parts, Radix Glycyrrhizae; Herba Hemipiliae Flabellatae 14 parts; Cortex Mori 12 parts; Fishing stalk 14 parts; Radix Pseudostellariae 16 parts; Indigofera fortunei Craib 13 parts; Herba Cremanthodii plantaginei 14 parts; Caulis Akebiae 12 parts; Flos kerriae japonicae 13 parts; Indigo Naturalis 10 parts; Calyx seu Fructus physalis 14 parts; Concretio Silicea Bambusae 15 parts; Herba Saniculae lamelligerae 10 parts.
The preparation method of the heat-clearing and detoxifying herb composition tablet of above-mentioned treatment pneumonia, step is as follows:
(1) smashed by Gypsum Fibrosum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 35 minutes, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 3 hours, puts in tank, and airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, crosses 140 mesh sieves;
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 35 minutes, add step (3) gains, decoct twice, boil 35 minutes, twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 4 hours, filter, be condensed into the thick paste that relative density is 1.20, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 2 days courses for the treatment of.
model case twoconsolidate XX, female, 8 years old, people from Liaocheng of Shandong Province.Before about 10 days, snowed heavily one, weather is colder, and infant insists on making a snowman, and plays extremely at that time, and result just starts cough and got up evening on the same day, and with mild fever, 37.7 DEG C, has taken some coldrexs at that time, also and take it seriously.But occur the next morning having a high fever to 39.3 DEG C, ill health etc., so just had a rest after taking febrifuge and some coldrexs, noon, symptom was eased, but cough is relatively more serious, so take the medicine of coldrex and treatment cough simultaneously, after 2 days, cough is more serious, has no alternative and goes to see a doctor, be defined as bronchopneumonia, treat a Zhou Houwu and be clearly better.
After taking 2 courses for the treatment of of heat-clearing and detoxifying herb composition tablet (embodiment 4) of gained of the present invention treatment pneumonia, symptom obviously alleviates, and body temperature remains normal, and cough also obviously alleviates.After continuing to take 2 courses for the treatment of, go to hospital to check and learn that indices reaches normal level, reach clinical cure.Later stage follows up a case by regular visits to and learns and fully recover, without recurrence.
embodiment 5treat a heat-clearing and detoxifying herb compositions for pneumonia, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): Fructus Gardeniae 13 parts; Radix Rhodiolae 16 parts; Gypsum Fibrosum 5.5 parts; If excellent Herba chenopodii 12 parts; 15 parts, Radix Glycyrrhizae; Herba Hemipiliae Flabellatae 12 parts; Cortex Mori 11 parts; Fishing stalk 12 parts; Radix Pseudostellariae 15 parts; Indigofera fortunei Craib 12 parts; Herba Cremanthodii plantaginei 13 parts; Caulis Akebiae 11 parts; Flos kerriae japonicae 12 parts; Indigo Naturalis 9 parts; Calyx seu Fructus physalis 13 parts; Concretio Silicea Bambusae 14 parts; Herba Saniculae lamelligerae 9 parts.
The preparation method of the heat-clearing and detoxifying herb composition granule of above-mentioned treatment pneumonia, step is as follows:
(1) smashed by Gypsum Fibrosum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 35 minutes, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 3 hours, puts in tank, and airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, crosses 140 mesh sieves;
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 35 minutes, add step (3) gains, decoct twice, boil 35 minutes, twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 4 hours, filter, being concentrated into relative density is 1.15(40 DEG C) thick paste, add simple syrup, mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, every day 3 times, 2 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Gardeniae: bitter in the mouth, cold in nature.GUIXIN, lung, tri-jiao channel.Another name SHANZHIZI etc.For the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.There is pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Radix Rhodiolae: sweet in the mouth, hardship, property is put down.Return lung, heart channel.For the dry root and rhizome of crassulaceae plants Radix Rhodiolae.There is benefiting QI for activating blood circulation, effect of relievining asthma of promoting blood circulation.For blood stasis due to qi deficiency. obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted.
Gypsum Fibrosum: main component is hydrous calcium sulfate.In addition, the ferrum, magnesium etc. of a small amount of silicic acid, aluminium hydroxide, sulfide and trace is still had.Have clearing away heat-fire, relieving restlessness is quenched the thirst, effect of convergence granulation promoting.For epidemic febrile disease edema caused by disorder of QI excess-heat, epidemic febrile disease intense heat in both QI and blood systems, Gao Refa speckle, dyspnea and cough due to lung-heat, restlessness and thirst, the high Sheng of stomach-fire, headache, toothache, gingival swelling and pain, eczema, skin infection is not held back after bursting, burn due to hot liquid or fire; Outer in order to heat clearing away sore, granulation promoting.
If excellent Herba chenopodii: lightly seasoned, cold nature.For the inflorescence of chenopod ceratoides latens.There is removing heat from the lung and dissipating phlegm, effect of cough-relieving.For tracheitis, pulmonary tuberculosis.
Radix Glycyrrhizae: sweet in the mouth, property is put down.GUIXIN.Lung, spleen, stomach warp.For the dry root and rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity.
Herba Hemipiliae Flabellatae: sweet in the mouth, micro-hardship, property is put down.Return lung meridian.For the herb of orchid fan words beak orchid.There is nourishing YIN and moistening the lung, tonify deficiency, effect of hemostasis.For lung-heat type cough, consumptive disease is coughed, deficient impairment caused by overstrain, deficiency-heat, night sweat, lumbago due to renal deficiency, traumatic hemorrhage.
Cortex Mori: sweet in the mouth, cold in nature.Return lung meridian.For the dry root bark of moraceae plants Mulberry.There is eliminating pathogen from the lung for relieving asthma, effect of inducing diuresis to remove edema.For dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.
Fishing stalk: mildly bitter flavor, cool in nature.For the herb of goatweed veronicastrum latifoliumYamazaki or thin fringe Herba veronicastri villosuli.There is heat-clearing and toxic substances removing, row water, effect of dissipating blood stasis.For controlling cough due to lung-heat, dysentery, hepatitis, edema, traumatic injury, venom, burn and scald.
Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down.Return spleen, lung meridian.For the dried root of pinkwort Radix Ginseng.There is replenishing QI to invigorate the spleen, effect of promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Indigofera fortunei Craib: bitter in the mouth, cold in nature.For root and the leaf of pulse family anil indigofera fortunei Craib.There is heat-clearing and toxic substances removing, effect of reducing swelling and alleviating pain.For epidemic encephalitis type B, laryngopharynx swelling and pain, pneumonia, venom.
Herba Cremanthodii plantaginei: sweet in the mouth, hardship, warm in nature.For the herb of feverfew Herba Cremanthodii plantaginei.There is expelling phlegm for arresting cough, effect of the chest stuffiness relieving promoting the circulation of QI.For phlegm dyspnea cough, impairment caused by overstrain, old weak headache, anemopyretic cold, has a headache dizzy, and conjunctival congestion and swelling pain, eyes is dim-sighted.
Caulis Akebiae: bitter in the mouth, cold nature.GUIXIN, small intestinal, urinary bladder channel.For the dry rattan of plants of Lardizabalaceae Caulis Akebiae, threeleaf akebia or Caulis Akebiae.There is clearing away heart-fire, diuresis, the effect of stimulating milk secretion of stimulating the menstrual flow.For irritable feverish sensation in the chest, larynx disease pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, amenorrhea breast is few.
Flos kerriae japonicae: bitter in the mouth, puckery, property is put down.Return lung, stomach, spleen channel.For flower or the branch and leaf of dicotyledon medicine rosaceous plant kerria.Flower, containing waxiness pigment, is the mixture of helenine, lutein dipalmitate, xanthophyll-oil acid esters.Leaf is containing vitamin C.There is preventing phlegm from forming and stopping coughing, expelling wind and removing dampness, effect of removing toxic substances.For pulmonary tuberculosis cough, rheumatic arthritis, rheumatic arthralgia, puerperal impairment caused by overstrain pain, edema, dysuria, dyspepsia, swollen ulcer drug, eczema, urticaria.
Indigo Naturalis: salty in the mouth, cold in nature.Return Liver Channel.For the leaf of acanthaceous vegetable acanthaceous indigo, polygonaceae plant polygonum tinctorium ait. or cruciferae isatis or stem and leaf are through processing obtained dried powder or agglomerate.There is heat-clearing and toxic substances removing, removing heat from blood, effect of arresting convulsion.For maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
Calyx seu Fructus physalis: sour in the mouth, sweet, cold in nature.Return lung, kidney channel.For the fruit of the band Constellation calyx of Solanaceae monkey flower Calyx seu Fructus physalis and Calyx seu fructus physalis.There is removing heat from the lung and relieving sorethroat, the effect of the diuretic that reduces phlegm.For lung-heat productive cough, pertussis, hoarseness pharyngalgia, hectic fever due to YIN-deficiency consumptive fever, urine leaching is puckery, sky bleb eczema, difficult labour.
Concretio Silicea Bambusae: sweet in the mouth, cold in nature.GUIXIN, Liver Channel.For the dried block of juice in the stalks such as grass Chinese textile bamboo or schizostachyum chinense Rendle.There is clear heat and eliminate phlegm, effect of cool heart arresting convulsion.For calentura coma, middle wind-phlegm fan, the hot diarrhea induced by fright of children's's expectorant, tic, night cry.
Herba Saniculae lamelligerae: acrid in the mouth, sweet, slightly warm in nature.Return lung, Liver Channel.For the herb of samphire thin slice sanicle.Having dispels the wind delivers, preventing phlegm from forming and stopping coughing, effect of promoting blood flow to regulate menstruation.For flu, cough, asthma, menoxenia, amenorrhea, dysmenorrhea, skin ulcer swells, treating swelling and pain by traumatic injury, traumatic hemorrhage.
test examplein order to verify the curative effect of the heat-clearing and detoxifying herb compositions (embodiment 5) of gained of the present invention treatment pneumonia, do contrast test in June ,-2010 in April, 2008:
General data: screening 280 routine patients with pneumonias, wherein male patient 137 people, female patient 143 people; Minimal ages 6 years old, max age 68 years old, 41.8 years old mean age; 6-20 year 82 people, 21-35 year 49 people, 36-50 year 71 people, 51-68 year 78 people.Be divided into experimental group and matched group two groups (wherein experimental group 180 people at random, matched group 100 people), two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.
Diagnostic criteria: possessing following 3 can make a definite diagnosis, 1. onset is anxious, has shiver with cold, heating, chest pain, cough, expectoration, occurs the symptom such as purulent sputum or bloody sputum.2. routine blood test can show leukocytosis, and neutrophilic granulocyte ratio increases and shift to left phenomenon.3. x-ray inspection: one or both sides lung field inflammatory infiltration shade.
Usage and dosage: experimental group takes the heat-clearing and detoxifying herb composition granule of gained of the present invention treatment pneumonia, each 1 bag, every day 3 times, 2 days courses for the treatment of.Matched group uses other medicine (as compound Puqi capsules, cefixime dispersible tablet etc.), wherein, and compound Puqi capsules: oral, a 2-4 grain, three times on the one, one after each meal.Cefixime dispersible tablet: oral, can directly with water delivery service, or this product is added in appropriate warm water (can stir) after dispersing and dissolving and take, the 1. child of adult and body weight more than 30 kilograms: 50-100mg at every turn, a twice-daily; 2. children's: each 1.5-3mg/kg, a twice-daily.
Criterion of therapeutical effect: cure: symptom all disappears, and main Physico-chemical tests index is normally.Effective: symptomatology is eliminated or cardinal symptom is eliminated, and main Physico-chemical tests index makes moderate progress.Invalid: main Physico-chemical tests index is front unchanged even more serious with treatment.
4 courses for the treatment of of medication treatment, observe latter 3 months for the treatment of.The Comparison of therapeutic of the experimental group of the matched group taking other drug and the heat-clearing and detoxifying herb compositions taking gained of the present invention treatment pneumonia, result is as shown in table 1:
Table 1
As can be seen from Table 1, take the cure rate of the heat-clearing and detoxifying herb compositions of gained of the present invention treatment pneumonia up to 73.33%, effective percentage is up to 97.22%; And the cure rate taking other drug only 43%, effective percentage also only has 81%, and inefficiency is up to 19%.So the successful of the heat-clearing and detoxifying herb compositions of gained treatment pneumonia of the present invention is better than the effect of other drug.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a heat-clearing and detoxifying herb compositions for pneumonia, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from: Fructus Gardeniae 10-16 part; Radix Rhodiolae 14-18 part; Gypsum Fibrosum 4-7 part; If excellent Herba chenopodii 8-16 part; Radix Glycyrrhizae 12-18 part; Herba Hemipiliae Flabellatae 9-16 part; Cortex Mori 7-15 part; Fishing stalk 9-16 part; Radix Pseudostellariae 10-19 part; Indigofera fortunei Craib 8-15 part; Herba Cremanthodii plantaginei 10-16 part; Caulis Akebiae 7-14 part; Flos kerriae japonicae 10-14 part; Indigo Naturalis 6-12 part; Calyx seu Fructus physalis 11-15 part; Concretio Silicea Bambusae 12-16 part; Herba Saniculae lamelligerae 5-13 part.
2. heat-clearing and detoxifying herb compositions according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Fructus Gardeniae 12-14 part; Radix Rhodiolae 15-17 part; Gypsum Fibrosum 5-6 part; If excellent Herba chenopodii 11-13 part; Radix Glycyrrhizae 14-16 part; Herba Hemipiliae Flabellatae 11-14 part; Cortex Mori 10-12 part; Fishing stalk 11-14 part; Radix Pseudostellariae 13-16 part; Indigofera fortunei Craib 10-13 part; Herba Cremanthodii plantaginei 12-14 part; Caulis Akebiae 9-12 part; Flos kerriae japonicae 11-13 part; Indigo Naturalis 8-10 part; Calyx seu Fructus physalis 12-14 part; Concretio Silicea Bambusae 13-15 part; Herba Saniculae lamelligerae 8-10 part.
3. heat-clearing and detoxifying herb compositions according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Fructus Gardeniae 13 parts; Radix Rhodiolae 16 parts; Gypsum Fibrosum 5.5 parts; If excellent Herba chenopodii 12 parts; 15 parts, Radix Glycyrrhizae; Herba Hemipiliae Flabellatae 12 parts; Cortex Mori 11 parts; Fishing stalk 12 parts; Radix Pseudostellariae 15 parts; Indigofera fortunei Craib 12 parts; Herba Cremanthodii plantaginei 13 parts; Caulis Akebiae 11 parts; Flos kerriae japonicae 12 parts; Indigo Naturalis 9 parts; Calyx seu Fructus physalis 13 parts; Concretio Silicea Bambusae 14 parts; Herba Saniculae lamelligerae 9 parts.
4., according to the arbitrary described heat-clearing and detoxifying herb compositions of claim 1-3, it is characterized in that, the preparation method of described powder, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Indigo Naturalis, Calyx seu Fructus physalis, Concretio Silicea Bambusae and Herba Saniculae lamelligerae are dried, pulverize, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) by step (1)-(4) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
5., according to the arbitrary described heat-clearing and detoxifying herb compositions of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 30-40 minute, add step (3) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 4-6 hour, filter, be concentrated into 1/2 of original volume, obtain decoction.
6. the preparation method of heat-clearing and detoxifying herb compositions decoction according to claim 5, it is characterized in that: the consumption of the preferred yellow wine of step (4) is the 15%-20% of Indigo Naturalis and Concretio Silicea Bambusae gross mass, and the consumption being more preferably yellow wine is 18% of Indigo Naturalis and Concretio Silicea Bambusae gross mass.
7., according to the arbitrary described heat-clearing and detoxifying herb compositions of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 30-40 minute, add step (3) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 3-5 hour, filter, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
8., according to the arbitrary described heat-clearing and detoxifying herb compositions of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 30-40 minute, add step (3) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 3-5 hour, filter, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make tablet.
9., according to the arbitrary described heat-clearing and detoxifying herb compositions of claim 1-3, it is characterized in that, the preparation method of described granule, step is as follows:
(1) Gypsum Fibrosum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) smashed to pieces by Radix Glycyrrhizae, decoct with water 2 times, each decoction 20-30 minute, filters, merging filtrate;
(3) by Radix Rhodiolae and Radix Pseudostellariae section, be placed in marmite, add step (2) gained filtrate, soak 30-40 minute, slow fire is heated to cease fire when liquorice liquid is boiled dry substantially, takes out, cools;
(4) be placed in glass container by Indigo Naturalis and Concretio Silicea Bambusae, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) if Fructus Gardeniae, excellent Herba chenopodii, Herba Hemipiliae Flabellatae, Cortex Mori, fishing stalk, indigofera fortunei Craib, Herba Cremanthodii plantaginei, Caulis Akebiae, Flos kerriae japonicae, Calyx seu Fructus physalis and Herba Saniculae lamelligerae are cleaned, be placed in marmite, soak 30-40 minute, add step (3) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(6) step (1) gains and step (4) gains are joined in step (5) gained filtrate, mixing, leave standstill 3-5 hour, filter, being concentrated into relative density is 1.10.-1.20(40 DEG C) thick paste, add simple syrup, mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
10. the preparation method of heat-clearing and detoxifying herb composition granule according to claim 9, is characterized in that: the consumption of the preferred simple syrup of step (6) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
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