CN106659742B - 表达免疫应答刺激细胞因子以吸引和/或激活免疫细胞的基因修饰间充质干细胞 - Google Patents
表达免疫应答刺激细胞因子以吸引和/或激活免疫细胞的基因修饰间充质干细胞 Download PDFInfo
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14181283.4 | 2014-08-18 | ||
| EP14181283 | 2014-08-18 | ||
| PCT/EP2015/068942 WO2016026854A2 (en) | 2014-08-18 | 2015-08-18 | Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106659742A CN106659742A (zh) | 2017-05-10 |
| CN106659742B true CN106659742B (zh) | 2021-09-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580045089.6A Active CN106659742B (zh) | 2014-08-18 | 2015-08-18 | 表达免疫应答刺激细胞因子以吸引和/或激活免疫细胞的基因修饰间充质干细胞 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20170239297A1 (enExample) |
| EP (2) | EP3182984B1 (enExample) |
| JP (1) | JP6712993B2 (enExample) |
| CN (1) | CN106659742B (enExample) |
| AU (1) | AU2015306231B2 (enExample) |
| CA (1) | CA2956987C (enExample) |
| IL (1) | IL250388B (enExample) |
| WO (1) | WO2016026854A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
| PT3107573T (pt) * | 2014-02-19 | 2019-01-10 | Merck Patent Gmbh | Imunoterapia com il-12 visada ao cancro |
| CA3008352A1 (en) * | 2016-04-01 | 2017-10-05 | Apceth Gmbh & Co. Kg | Mesenchymal stem cells to enhance anti-tumor activity of immunotherapy |
| US11529393B2 (en) | 2016-10-10 | 2022-12-20 | The Board Of Trustees Of The Leland Stanford Junior University | Mesenchymal stem cells expressing anti-inflammatory cytokines and methods of use |
| CN108148862B (zh) * | 2016-12-05 | 2019-03-08 | 上海优卡迪生物医药科技有限公司 | 一种封闭pdl1的用于抑制免疫逃脱的car-t转基因载体及其构建方法和应用 |
| US20200085876A1 (en) * | 2017-03-17 | 2020-03-19 | Senti Biosciences, Inc. | Immunomodulating cell circuits |
| CN110678191A (zh) * | 2017-04-07 | 2020-01-10 | 洋蓟治疗有限公司 | 治疗嵌合抗原受体(car)t细胞疗法的副作用的方法 |
| AU2018251898A1 (en) * | 2017-04-13 | 2019-10-31 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| CN107184602B (zh) * | 2017-06-01 | 2020-06-30 | 刘未斌 | 一种治疗肿瘤的药物组合 |
| CN107184603B (zh) * | 2017-06-01 | 2020-06-30 | 刘未斌 | 一种治疗肿瘤的药物组合 |
| JP2020523400A (ja) * | 2017-06-16 | 2020-08-06 | サイナータ セラピューティクス リミテッド | 免疫療法の副作用を治療するための方法 |
| WO2019067491A1 (en) * | 2017-09-29 | 2019-04-04 | Oncocyclist, Inc. | COMPOSITION AND METHOD FOR TREATING CELL PROLIFERATION |
| WO2019104037A1 (en) | 2017-11-22 | 2019-05-31 | The Brigham And Women's Hospital, Inc. | Msc-expressed immunomodulators in combination with car-t for cancer therapy |
| IL264068B2 (en) | 2018-01-05 | 2023-07-01 | Great Novel Therapeutics Biotech & Medicals Corp | Aggregate and pharmaceutical preparation containing an hdac inhibitor and an nsaid aggregate together with an immune checkpoint inhibitor for use in a method for removing immunosuppression in the microenvironment of a tumor or stimulating an immune system against cancer cells |
| KR20200108316A (ko) * | 2018-01-12 | 2020-09-17 | 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 | 세포 리프로그래밍 요법 |
| WO2019144945A1 (en) | 2018-01-25 | 2019-08-01 | I-Mab | Anti-pd-l1 antibody and il-7 fusions |
| US11844834B2 (en) | 2018-02-02 | 2023-12-19 | Sl Vaxigen, Inc. | Vaccine adjuvant |
| CN111836888B (zh) * | 2018-03-21 | 2024-01-12 | 洪明奇 | 用于癌症治疗的工程化干细胞 |
| CN108864288A (zh) * | 2018-04-26 | 2018-11-23 | 上海怡豪生物科技有限公司 | 乳腺癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN110527696A (zh) * | 2018-06-13 | 2019-12-03 | 中山大学 | 一种IFNβ和FerritinH基因联合修饰的骨髓间充质干细胞及其制备方法和应用 |
| CN108815188A (zh) * | 2018-07-06 | 2018-11-16 | 浙江生创精准医疗科技有限公司 | 包含间充质干细胞制剂与免疫检查点抑制剂的肿瘤治疗组合物、试剂盒及其用途 |
| US20210346430A9 (en) * | 2018-08-26 | 2021-11-11 | Oaiscell Biotechnologies | Method for treating glioblastoma |
| CN112771167B (zh) * | 2018-09-20 | 2025-09-26 | 克莱格医学有限公司 | 表达有趋化因子的细胞及用途 |
| CN113286874A (zh) * | 2018-10-12 | 2021-08-20 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(CARs)组合物及使用方法 |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| AU2019359890B2 (en) | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| CN109593725A (zh) * | 2018-12-25 | 2019-04-09 | 河北生命原点生物科技有限公司 | 一种重组间充质干细胞及其应用 |
| BR112021015791A2 (pt) * | 2019-02-14 | 2021-10-05 | Research Institute At Nationwide Children's Hospital | Uso de partículas de membrana plasmática, lipossomas e exossomas para testar a potência de células imunes |
| CN109762820B (zh) * | 2019-02-18 | 2020-07-28 | 河北佑仁生物科技有限公司 | 一种骨髓间充质干细胞特异性启动元件在干细胞中的应用 |
| EP3946440A4 (en) * | 2019-04-02 | 2023-04-19 | The General Hospital Corporation | Methods to enhance t cell regeneration |
| CN115851605A (zh) * | 2019-04-18 | 2023-03-28 | 上海交通大学 | 间充质干细胞靶向运输趋化因子和细胞因子的免疫疗法 |
| CN111139222B (zh) * | 2019-05-30 | 2020-12-29 | 北京双因生物科技有限公司 | 一种重组间充质干细胞及其制备方法和用途 |
| EP4556072A3 (en) * | 2019-08-23 | 2025-06-11 | Orbsen Therapeutics Limited | Compositions for monocyte and macrophage polarization and methods of use |
| CN115516101A (zh) * | 2020-03-26 | 2022-12-23 | 新加坡科技研究局 | 将一种或多种外源物质引入免疫细胞的方法和系统 |
| MX2022014766A (es) * | 2020-05-27 | 2023-02-22 | Univ Zuerich | Vectores virales que expresan proteinas terapeuticas especificamente en celulas mieloides y microglia. |
| JP7758370B2 (ja) * | 2020-07-16 | 2025-10-22 | チャンジェン セラピューティクス (シャンハイ) カンパニー リミテッド | 間葉系幹細胞によるケモカインおよびサイトカイン送達を標的とする免疫療法 |
| US20230399622A1 (en) * | 2020-10-16 | 2023-12-14 | Fundació Centre De Regulació Genòmica | Therapy for degenerative disease and tissue damage |
| CN114507643A (zh) * | 2020-10-29 | 2022-05-17 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-2的多能干细胞衍生物及应用 |
| CN114426953A (zh) * | 2020-10-29 | 2022-05-03 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-12的多能干细胞衍生物及应用 |
| CN114717232A (zh) * | 2020-12-22 | 2022-07-08 | 未来智人再生医学研究院(广州)有限公司 | 表达irf-1靶向抑制因子的多能干细胞及其衍生物与应用 |
| WO2023274355A1 (zh) * | 2021-07-02 | 2023-01-05 | 上海交通大学 | 改造的间充质干细胞和免疫效应细胞联合治疗肿瘤 |
| US20230137723A1 (en) * | 2021-11-01 | 2023-05-04 | MAM Holdings of West Florida, L.L.C. | Mesenchymal stem cells for the prevention and targeted treatment of cancer and other disorders |
| CN114480413B (zh) * | 2022-01-14 | 2022-11-04 | 北京贝来生物科技有限公司 | 一种活化肿瘤免疫应答的基因修饰干细胞制备方法 |
| CN115463155B (zh) * | 2022-11-01 | 2023-05-23 | 卡瑞济(北京)生命科技有限公司 | 间充质干细胞的用途 |
| CN117503952B (zh) * | 2022-11-24 | 2025-09-16 | 中国药科大学 | 一种基于血小板的免疫激活系统及其制备方法和应用 |
| WO2024137869A2 (en) * | 2022-12-20 | 2024-06-27 | City Of Hope | Stem cells for delivery of oncolytic viruses |
| US20250333700A1 (en) * | 2024-02-28 | 2025-10-30 | Gene Solutions Joint Stock Company | Modified k562 feeder cell line expressing factors that enhance the activation and proliferation of natural killer cells and a method for its production |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1842339A (zh) * | 2003-06-27 | 2006-10-04 | 株式会社雷诺再生医学研究所 | 含有间叶细胞作为有效成分、治疗脑神经疾病的体内给药治疗剂 |
| CN101083910A (zh) * | 2004-09-10 | 2007-12-05 | 同源治疗公司 | 用于预防和治疗移植中的免疫应答的肝脏基质细胞 |
| CN101778934A (zh) * | 2007-05-24 | 2010-07-14 | 埃普塞斯有限责任两合公司 | Cd34干细胞相关方法和组合物 |
| CN101974485A (zh) * | 2010-11-12 | 2011-02-16 | 苏州大学 | 具有最佳迁移能力的间充质干细胞的制备方法及其应用 |
| CN102471753A (zh) * | 2009-12-08 | 2012-05-23 | 伊利诺伊大学理事会 | 干细胞免疫调节应用方法和设备 |
| CN102695517A (zh) * | 2009-04-13 | 2012-09-26 | 埃普塞斯有限责任两合公司 | 经改造的间充质干细胞和用其治疗肿瘤的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1487463A2 (en) | 2002-03-02 | 2004-12-22 | Board Of Regents The University Of Texas System | Local production and/or delivery of anti-cancer agents by stromal cell precursors |
| JPWO2005007176A1 (ja) * | 2003-06-27 | 2006-08-31 | 株式会社レノメディクス研究所 | 間葉系細胞を有効成分とする体内投与用脳神経疾患治療薬 |
| US20050002904A1 (en) | 2003-07-03 | 2005-01-06 | Wary Kishore K. | Uses of vascular endothelial growth factor and type I collagen inducible protein (VCIP) |
| EP1757703A3 (en) | 2005-08-24 | 2007-12-05 | Medizinische Hochschule Hannover | Self-inactivating retroviral vector |
| EP2019134A1 (en) | 2007-07-26 | 2009-01-28 | Vision 7 GmbH | Gene therapy of chronic granulomatous disease |
| US9101597B2 (en) | 2013-03-14 | 2015-08-11 | The Administration Of The Tulane Educational Fund | Immunoprotective primary mesenchymal stem cells and methods |
| AR097570A1 (es) * | 2013-09-06 | 2016-03-23 | Consejo Nac De Investig Científicas Y Técnicas (Conicet) | Composiciones y métodos para incrementar la migración de células mesenquimales del estroma hacia tumores |
| ES2963718T3 (es) * | 2014-01-21 | 2024-04-01 | Novartis Ag | Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras |
| WO2016146819A1 (en) * | 2015-03-18 | 2016-09-22 | Apceth Gmbh & Co. Kg | Hypoxia-induced expression of therapeutic proteins in mesenchymal stem cells |
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- 2015-08-18 WO PCT/EP2015/068942 patent/WO2016026854A2/en not_active Ceased
- 2015-08-18 US US15/504,554 patent/US20170239297A1/en not_active Abandoned
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- 2015-08-18 EP EP19205297.5A patent/EP3656387A3/en not_active Withdrawn
- 2015-08-18 JP JP2017509626A patent/JP6712993B2/ja active Active
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2020
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1842339A (zh) * | 2003-06-27 | 2006-10-04 | 株式会社雷诺再生医学研究所 | 含有间叶细胞作为有效成分、治疗脑神经疾病的体内给药治疗剂 |
| CN101083910A (zh) * | 2004-09-10 | 2007-12-05 | 同源治疗公司 | 用于预防和治疗移植中的免疫应答的肝脏基质细胞 |
| CN101778934A (zh) * | 2007-05-24 | 2010-07-14 | 埃普塞斯有限责任两合公司 | Cd34干细胞相关方法和组合物 |
| CN103263439A (zh) * | 2007-05-24 | 2013-08-28 | 埃普塞斯有限责任两合公司 | Cd34干细胞相关方法和组合物 |
| CN102695517A (zh) * | 2009-04-13 | 2012-09-26 | 埃普塞斯有限责任两合公司 | 经改造的间充质干细胞和用其治疗肿瘤的方法 |
| CN102471753A (zh) * | 2009-12-08 | 2012-05-23 | 伊利诺伊大学理事会 | 干细胞免疫调节应用方法和设备 |
| CN101974485A (zh) * | 2010-11-12 | 2011-02-16 | 苏州大学 | 具有最佳迁移能力的间充质干细胞的制备方法及其应用 |
Non-Patent Citations (7)
| Title |
|---|
| Cytokines transduced bone marrow stromal cell lines promote immunohematopoietic reconstitution in mice after allogeneic bone;Ailing Li等;《Immunology Letters》;20050515;第98卷(第2期);第216-224页 * |
| IL-12 、IL-7 、IL-2 体外协同诱导人PBMC增殖和PBMC杀瘤活性的实验研究;徐红薇等;《中国免疫学杂志》;19980920;第14卷(第5期);第338页摘要,第339页左栏第2.1-2.2节,第340页左栏第3节 * |
| IL-7 Enhances the Responsiveness of Human T Cells That Develop in the Bone Marrow of Athymic Mice;Eleanor C. Tsark等;《The Journal of Immunology》;20010101;第166卷(第1期);第170-181页 * |
| Mechanisms of and perspectives on the mesenchymal stem cell in immunotherapy;ROBERT CHUNHUA ZHAO等;《Journal of Laboratory and Clinical Meddicine》;20040531;第143卷(第5期);第284-291页 * |
| Mesenchymal stem cells: A promising targeted-delivery vehicle in cancer gene therapy;Yu-Lan Hu等;《Journal of Controlled Release》;20101015;第147卷(第2期);第154-162页 * |
| Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma;Peng Gao 等,;《Cancer Letters》;20100428;第290卷(第2期);第157-158页"Abstract"、"Introduction"字段,第161页第3.6节 * |
| 人白细胞介素12腺病毒载体构建及在人骨髓间充质干细胞中的表达;Chen Yuan-yuan等;《中国组织工程研究与临床康复》;20100604;第14卷(第23期);第4186-4190页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2956987C (en) | 2023-03-21 |
| IL250388A0 (en) | 2017-03-30 |
| US11464806B2 (en) | 2022-10-11 |
| EP3182984B1 (en) | 2019-10-30 |
| US20170239297A1 (en) | 2017-08-24 |
| US20200268802A1 (en) | 2020-08-27 |
| IL250388B (en) | 2021-02-28 |
| CN106659742A (zh) | 2017-05-10 |
| CA2956987A1 (en) | 2016-02-25 |
| EP3656387A2 (en) | 2020-05-27 |
| WO2016026854A2 (en) | 2016-02-25 |
| AU2015306231B2 (en) | 2019-11-21 |
| JP6712993B2 (ja) | 2020-06-24 |
| WO2016026854A3 (en) | 2016-04-14 |
| JP2017525364A (ja) | 2017-09-07 |
| EP3656387A3 (en) | 2020-07-01 |
| EP3182984A2 (en) | 2017-06-28 |
| AU2015306231A1 (en) | 2017-02-23 |
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