CA2956987C - Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells - Google Patents
Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells Download PDFInfo
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| CN108815188A (zh) * | 2018-07-06 | 2018-11-16 | 浙江生创精准医疗科技有限公司 | 包含间充质干细胞制剂与免疫检查点抑制剂的肿瘤治疗组合物、试剂盒及其用途 |
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| CN109593725A (zh) * | 2018-12-25 | 2019-04-09 | 河北生命原点生物科技有限公司 | 一种重组间充质干细胞及其应用 |
| US20220128541A1 (en) * | 2019-02-14 | 2022-04-28 | Research Institute At Nationwide Children's Hospital | Use of plasma membrane particles, liposomes, and exosomes to assay immune cell potency |
| CN109762820B (zh) * | 2019-02-18 | 2020-07-28 | 河北佑仁生物科技有限公司 | 一种骨髓间充质干细胞特异性启动元件在干细胞中的应用 |
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| CN111139222B (zh) * | 2019-05-30 | 2020-12-29 | 北京双因生物科技有限公司 | 一种重组间充质干细胞及其制备方法和用途 |
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| US20230399622A1 (en) * | 2020-10-16 | 2023-12-14 | Fundació Centre De Regulació Genòmica | Therapy for degenerative disease and tissue damage |
| CN114426953A (zh) * | 2020-10-29 | 2022-05-03 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-12的多能干细胞衍生物及应用 |
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| WO2023274355A1 (zh) * | 2021-07-02 | 2023-01-05 | 上海交通大学 | 改造的间充质干细胞和免疫效应细胞联合治疗肿瘤 |
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| KR20120088542A (ko) | 2009-04-13 | 2012-08-08 | 아프세스 게엠베하 & 씨오. 카게 | 종양 치료를 위한 조작된 중간엽 줄기세포 및 이를 사용하는 방법 |
| BR112012013780B8 (pt) * | 2009-12-08 | 2021-07-27 | Univ Illinois | biorreator para modular linfócitos e suprimir células t autorreativas, sistema para inibição de um distúrbio autoimune, e, método ativar células t reguladoras |
| CN101974485A (zh) * | 2010-11-12 | 2011-02-16 | 苏州大学 | 具有最佳迁移能力的间充质干细胞的制备方法及其应用 |
| US9101597B2 (en) | 2013-03-14 | 2015-08-11 | The Administration Of The Tulane Educational Fund | Immunoprotective primary mesenchymal stem cells and methods |
| AR097570A1 (es) * | 2013-09-06 | 2016-03-23 | Consejo Nac De Investig Científicas Y Técnicas (Conicet) | Composiciones y métodos para incrementar la migración de células mesenquimales del estroma hacia tumores |
| ES2963718T3 (es) * | 2014-01-21 | 2024-04-01 | Novartis Ag | Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras |
| WO2016146819A1 (en) * | 2015-03-18 | 2016-09-22 | Apceth Gmbh & Co. Kg | Hypoxia-induced expression of therapeutic proteins in mesenchymal stem cells |
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2015
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- 2015-08-18 EP EP19205297.5A patent/EP3656387A3/en not_active Withdrawn
- 2015-08-18 AU AU2015306231A patent/AU2015306231B2/en active Active
- 2015-08-18 US US15/504,554 patent/US20170239297A1/en not_active Abandoned
- 2015-08-18 WO PCT/EP2015/068942 patent/WO2016026854A2/en not_active Ceased
- 2015-08-18 JP JP2017509626A patent/JP6712993B2/ja active Active
- 2015-08-18 EP EP15759667.7A patent/EP3182984B1/en active Active
- 2015-08-18 CN CN201580045089.6A patent/CN106659742B/zh active Active
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2020
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| Publication number | Publication date |
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| EP3182984B1 (en) | 2019-10-30 |
| US11464806B2 (en) | 2022-10-11 |
| AU2015306231A1 (en) | 2017-02-23 |
| US20170239297A1 (en) | 2017-08-24 |
| CN106659742A (zh) | 2017-05-10 |
| CA2956987A1 (en) | 2016-02-25 |
| WO2016026854A2 (en) | 2016-02-25 |
| EP3182984A2 (en) | 2017-06-28 |
| EP3656387A2 (en) | 2020-05-27 |
| AU2015306231B2 (en) | 2019-11-21 |
| EP3656387A3 (en) | 2020-07-01 |
| JP6712993B2 (ja) | 2020-06-24 |
| CN106659742B (zh) | 2021-09-03 |
| WO2016026854A3 (en) | 2016-04-14 |
| US20200268802A1 (en) | 2020-08-27 |
| JP2017525364A (ja) | 2017-09-07 |
| IL250388B (en) | 2021-02-28 |
| IL250388A0 (en) | 2017-03-30 |
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