CN1066441C - 异唑基苯基磺酰胺的衍生物及其在制备内皮缩血管肽拮抗药中的应用 - Google Patents

异唑基苯基磺酰胺的衍生物及其在制备内皮缩血管肽拮抗药中的应用 Download PDF

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Publication number
CN1066441C
CN1066441C CN93107073A CN93107073A CN1066441C CN 1066441 C CN1066441 C CN 1066441C CN 93107073 A CN93107073 A CN 93107073A CN 93107073 A CN93107073 A CN 93107073A CN 1066441 C CN1066441 C CN 1066441C
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CN
China
Prior art keywords
isoxazolyl
dimethyl
xenyl
sulphonamide
methyl
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Expired - Fee Related
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CN93107073A
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English (en)
Chinese (zh)
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CN1084515A (zh
Inventor
Ｎ·穆卢盖桑
J·T·亨特
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ER Squibb and Sons LLC
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ER Squibb and Sons LLC
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Publication of CN1084515A publication Critical patent/CN1084515A/zh
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN93107073A 1992-05-06 1993-05-06 异唑基苯基磺酰胺的衍生物及其在制备内皮缩血管肽拮抗药中的应用 Expired - Fee Related CN1066441C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87900092A 1992-05-06 1992-05-06
US879,000 1992-05-06

Publications (2)

Publication Number Publication Date
CN1084515A CN1084515A (zh) 1994-03-30
CN1066441C true CN1066441C (zh) 2001-05-30

Family

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Family Applications (1)

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CN93107073A Expired - Fee Related CN1066441C (zh) 1992-05-06 1993-05-06 异唑基苯基磺酰胺的衍生物及其在制备内皮缩血管肽拮抗药中的应用

Country Status (22)

Country Link
EP (1) EP0569193B1 (enExample)
JP (1) JP3286391B2 (enExample)
KR (1) KR100277454B1 (enExample)
CN (1) CN1066441C (enExample)
AT (1) ATE149155T1 (enExample)
AU (1) AU659545B2 (enExample)
CA (1) CA2095174A1 (enExample)
CY (1) CY2016A (enExample)
DE (1) DE69308229T2 (enExample)
DK (1) DK0569193T3 (enExample)
ES (1) ES2100459T3 (enExample)
FI (1) FI112655B (enExample)
GR (1) GR3023421T3 (enExample)
HK (1) HK98197A (enExample)
HU (1) HU218938B (enExample)
IL (1) IL105481A (enExample)
MX (1) MX9302618A (enExample)
NO (1) NO303065B1 (enExample)
NZ (1) NZ247440A (enExample)
PL (1) PL178165B1 (enExample)
RU (1) RU2133742C1 (enExample)
ZA (1) ZA932914B (enExample)

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AU3838293A (en) 1993-11-11
NO931638L (no) 1993-11-08
NO931638D0 (no) 1993-05-05
FI112655B (fi) 2003-12-31
GR3023421T3 (en) 1997-08-29
DK0569193T3 (enExample) 1997-03-17
RU2133742C1 (ru) 1999-07-27
NO303065B1 (no) 1998-05-25
JPH0649046A (ja) 1994-02-22
FI932052A0 (fi) 1993-05-06
PL298828A1 (en) 1993-12-27
CN1084515A (zh) 1994-03-30
PL178165B1 (pl) 2000-03-31
DE69308229T2 (de) 1997-07-17
JP3286391B2 (ja) 2002-05-27
ATE149155T1 (de) 1997-03-15
FI932052L (fi) 1993-11-07
MX9302618A (es) 1994-05-31
ZA932914B (en) 1993-11-12
HU9301305D0 (en) 1993-09-28
KR100277454B1 (ko) 2001-01-15
NZ247440A (en) 1995-04-27
IL105481A0 (en) 1993-08-18
CA2095174A1 (en) 1993-11-07
CY2016A (en) 1998-02-20
DE69308229D1 (de) 1997-04-03
EP0569193B1 (en) 1997-02-26
HK98197A (en) 1997-08-08
ES2100459T3 (es) 1997-06-16
HUT65751A (en) 1994-07-28
AU659545B2 (en) 1995-05-18
HU218938B (hu) 2001-01-29
EP0569193A1 (en) 1993-11-10
IL105481A (en) 1996-12-05
KR930023337A (ko) 1993-12-18

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