HK98197A - N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists - Google Patents

N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists

Info

Publication number
HK98197A
HK98197A HK98197A HK98197A HK98197A HK 98197 A HK98197 A HK 98197A HK 98197 A HK98197 A HK 98197A HK 98197 A HK98197 A HK 98197A HK 98197 A HK98197 A HK 98197A
Authority
HK
Hong Kong
Prior art keywords
isoxazolyl
dimethyl
compound
biphenyl
sulfonamide
Prior art date
Application number
HK98197A
Other languages
German (de)
English (en)
French (fr)
Inventor
Murugesan Natesan
John T. Hunt
Original Assignee
E.R. Squibb & Sons, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E.R. Squibb & Sons, Inc. filed Critical E.R. Squibb & Sons, Inc.
Publication of HK98197A publication Critical patent/HK98197A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
HK98197A 1992-05-06 1997-06-26 N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists HK98197A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87900092A 1992-05-06 1992-05-06

Publications (1)

Publication Number Publication Date
HK98197A true HK98197A (en) 1997-08-08

Family

ID=25373236

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98197A HK98197A (en) 1992-05-06 1997-06-26 N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists

Country Status (22)

Country Link
EP (1) EP0569193B1 (enExample)
JP (1) JP3286391B2 (enExample)
KR (1) KR100277454B1 (enExample)
CN (1) CN1066441C (enExample)
AT (1) ATE149155T1 (enExample)
AU (1) AU659545B2 (enExample)
CA (1) CA2095174A1 (enExample)
CY (1) CY2016A (enExample)
DE (1) DE69308229T2 (enExample)
DK (1) DK0569193T3 (enExample)
ES (1) ES2100459T3 (enExample)
FI (1) FI112655B (enExample)
GR (1) GR3023421T3 (enExample)
HK (1) HK98197A (enExample)
HU (1) HU218938B (enExample)
IL (1) IL105481A (enExample)
MX (1) MX9302618A (enExample)
NO (1) NO303065B1 (enExample)
NZ (1) NZ247440A (enExample)
PL (1) PL178165B1 (enExample)
RU (1) RU2133742C1 (enExample)
ZA (1) ZA932914B (enExample)

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Also Published As

Publication number Publication date
CN1066441C (zh) 2001-05-30
KR100277454B1 (ko) 2001-01-15
FI932052L (fi) 1993-11-07
IL105481A0 (en) 1993-08-18
FI112655B (fi) 2003-12-31
HUT65751A (en) 1994-07-28
JPH0649046A (ja) 1994-02-22
PL178165B1 (pl) 2000-03-31
MX9302618A (es) 1994-05-31
FI932052A0 (fi) 1993-05-06
IL105481A (en) 1996-12-05
AU3838293A (en) 1993-11-11
EP0569193B1 (en) 1997-02-26
EP0569193A1 (en) 1993-11-10
JP3286391B2 (ja) 2002-05-27
ZA932914B (en) 1993-11-12
NZ247440A (en) 1995-04-27
HU9301305D0 (en) 1993-09-28
CA2095174A1 (en) 1993-11-07
DK0569193T3 (enExample) 1997-03-17
CN1084515A (zh) 1994-03-30
NO931638D0 (no) 1993-05-05
RU2133742C1 (ru) 1999-07-27
CY2016A (en) 1998-02-20
GR3023421T3 (en) 1997-08-29
DE69308229T2 (de) 1997-07-17
NO931638L (no) 1993-11-08
HU218938B (hu) 2001-01-29
PL298828A1 (en) 1993-12-27
DE69308229D1 (de) 1997-04-03
KR930023337A (ko) 1993-12-18
ATE149155T1 (de) 1997-03-15
ES2100459T3 (es) 1997-06-16
AU659545B2 (en) 1995-05-18
NO303065B1 (no) 1998-05-25

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