KR100277454B1 - 페닐 술폰아미드 엔도텔린 길항물질 - Google Patents

페닐 술폰아미드 엔도텔린 길항물질 Download PDF

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Publication number
KR100277454B1
KR100277454B1 KR1019930007628A KR930007628A KR100277454B1 KR 100277454 B1 KR100277454 B1 KR 100277454B1 KR 1019930007628 A KR1019930007628 A KR 1019930007628A KR 930007628 A KR930007628 A KR 930007628A KR 100277454 B1 KR100277454 B1 KR 100277454B1
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KR
South Korea
Prior art keywords
isoxazolyl
dimethyl
biphenyl
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019930007628A
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English (en)
Korean (ko)
Other versions
KR930023337A (ko
Inventor
머러기잔 네이티잰
티. 헌트 존
Original Assignee
스테픈 체스노프
이. 알. 스퀴부 앤드 선즈 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of KR930023337A publication Critical patent/KR930023337A/ko
Application granted granted Critical
Publication of KR100277454B1 publication Critical patent/KR100277454B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
KR1019930007628A 1992-05-06 1993-05-04 페닐 술폰아미드 엔도텔린 길항물질 Expired - Fee Related KR100277454B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87900092A 1992-05-06 1992-05-06
US07/879,000 1992-05-06
US7/879,000 1992-05-06

Publications (2)

Publication Number Publication Date
KR930023337A KR930023337A (ko) 1993-12-18
KR100277454B1 true KR100277454B1 (ko) 2001-01-15

Family

ID=25373236

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930007628A Expired - Fee Related KR100277454B1 (ko) 1992-05-06 1993-05-04 페닐 술폰아미드 엔도텔린 길항물질

Country Status (22)

Country Link
EP (1) EP0569193B1 (enExample)
JP (1) JP3286391B2 (enExample)
KR (1) KR100277454B1 (enExample)
CN (1) CN1066441C (enExample)
AT (1) ATE149155T1 (enExample)
AU (1) AU659545B2 (enExample)
CA (1) CA2095174A1 (enExample)
CY (1) CY2016A (enExample)
DE (1) DE69308229T2 (enExample)
DK (1) DK0569193T3 (enExample)
ES (1) ES2100459T3 (enExample)
FI (1) FI112655B (enExample)
GR (1) GR3023421T3 (enExample)
HK (1) HK98197A (enExample)
HU (1) HU218938B (enExample)
IL (1) IL105481A (enExample)
MX (1) MX9302618A (enExample)
NO (1) NO303065B1 (enExample)
NZ (1) NZ247440A (enExample)
PL (1) PL178165B1 (enExample)
RU (1) RU2133742C1 (enExample)
ZA (1) ZA932914B (enExample)

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Also Published As

Publication number Publication date
CN1066441C (zh) 2001-05-30
FI932052L (fi) 1993-11-07
IL105481A0 (en) 1993-08-18
FI112655B (fi) 2003-12-31
HUT65751A (en) 1994-07-28
HK98197A (en) 1997-08-08
JPH0649046A (ja) 1994-02-22
PL178165B1 (pl) 2000-03-31
MX9302618A (es) 1994-05-31
FI932052A0 (fi) 1993-05-06
IL105481A (en) 1996-12-05
AU3838293A (en) 1993-11-11
EP0569193B1 (en) 1997-02-26
EP0569193A1 (en) 1993-11-10
JP3286391B2 (ja) 2002-05-27
ZA932914B (en) 1993-11-12
NZ247440A (en) 1995-04-27
HU9301305D0 (en) 1993-09-28
CA2095174A1 (en) 1993-11-07
DK0569193T3 (enExample) 1997-03-17
CN1084515A (zh) 1994-03-30
NO931638D0 (no) 1993-05-05
RU2133742C1 (ru) 1999-07-27
CY2016A (en) 1998-02-20
GR3023421T3 (en) 1997-08-29
DE69308229T2 (de) 1997-07-17
NO931638L (no) 1993-11-08
HU218938B (hu) 2001-01-29
PL298828A1 (en) 1993-12-27
DE69308229D1 (de) 1997-04-03
KR930023337A (ko) 1993-12-18
ATE149155T1 (de) 1997-03-15
ES2100459T3 (es) 1997-06-16
AU659545B2 (en) 1995-05-18
NO303065B1 (no) 1998-05-25

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