CN106459062A - 作为PDE2抑制剂的取代的[1,2,4]三唑并[1,5‑a]嘧啶‑7‑基化合物 - Google Patents
作为PDE2抑制剂的取代的[1,2,4]三唑并[1,5‑a]嘧啶‑7‑基化合物 Download PDFInfo
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- CN106459062A CN106459062A CN201580030165.6A CN201580030165A CN106459062A CN 106459062 A CN106459062 A CN 106459062A CN 201580030165 A CN201580030165 A CN 201580030165A CN 106459062 A CN106459062 A CN 106459062A
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- methyl
- triazol
- pyrimidin
- base
- piperidines
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910367854.6A CN110092788B (zh) | 2014-04-23 | 2015-04-22 | 作为PDE2抑制剂的取代的[1,2,4]三唑并[1,5-a]嘧啶-7-基化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983387P | 2014-04-23 | 2014-04-23 | |
| US61/983,387 | 2014-04-23 | ||
| PCT/US2015/027102 WO2015164508A1 (en) | 2014-04-23 | 2015-04-22 | Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as pde2 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910367854.6A Division CN110092788B (zh) | 2014-04-23 | 2015-04-22 | 作为PDE2抑制剂的取代的[1,2,4]三唑并[1,5-a]嘧啶-7-基化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106459062A true CN106459062A (zh) | 2017-02-22 |
Family
ID=53055118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910367854.6A Active CN110092788B (zh) | 2014-04-23 | 2015-04-22 | 作为PDE2抑制剂的取代的[1,2,4]三唑并[1,5-a]嘧啶-7-基化合物 |
| CN201580030165.6A Pending CN106459062A (zh) | 2014-04-23 | 2015-04-22 | 作为PDE2抑制剂的取代的[1,2,4]三唑并[1,5‑a]嘧啶‑7‑基化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910367854.6A Active CN110092788B (zh) | 2014-04-23 | 2015-04-22 | 作为PDE2抑制剂的取代的[1,2,4]三唑并[1,5-a]嘧啶-7-基化合物 |
Country Status (23)
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| US (4) | US9932345B2 (pt-PT) |
| EP (2) | EP3134413B1 (pt-PT) |
| JP (1) | JP6626449B2 (pt-PT) |
| KR (1) | KR102471058B1 (pt-PT) |
| CN (2) | CN110092788B (pt-PT) |
| AU (2) | AU2015249753B2 (pt-PT) |
| BR (1) | BR112016024713B1 (pt-PT) |
| CA (1) | CA2938294C (pt-PT) |
| DK (2) | DK3597649T3 (pt-PT) |
| ES (2) | ES2902806T3 (pt-PT) |
| HR (1) | HRP20212035T1 (pt-PT) |
| HU (1) | HUE057317T2 (pt-PT) |
| IL (2) | IL248292A (pt-PT) |
| MA (1) | MA50375A (pt-PT) |
| MX (1) | MX358004B (pt-PT) |
| NZ (1) | NZ725161A (pt-PT) |
| PL (1) | PL3597649T3 (pt-PT) |
| PT (1) | PT3597649T (pt-PT) |
| RU (1) | RU2659070C9 (pt-PT) |
| SG (1) | SG11201606216UA (pt-PT) |
| SI (1) | SI3597649T1 (pt-PT) |
| TW (1) | TWI664181B (pt-PT) |
| WO (1) | WO2015164508A1 (pt-PT) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110325535A (zh) * | 2017-02-27 | 2019-10-11 | 詹森药业有限公司 | 经哌啶、吗啉或哌嗪取代的作为oga抑制剂的[1,2,4]-三唑[1,5-a]-嘧啶基衍生物 |
Families Citing this family (18)
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| WO2016073424A1 (en) | 2014-11-05 | 2016-05-12 | Dart Neuroscience, Llc | Substituted 5-methyl-[1, 2, 4] triazolo [1,5-a) pyrimidin-2-amine compounds as pde2 inhibitors |
| CN108349979B (zh) * | 2015-11-02 | 2021-04-09 | 詹森药业有限公司 | [1,2,4]三唑并[1,5-a]嘧啶-7-基化合物 |
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| ES2855032T3 (es) | 2016-11-02 | 2021-09-23 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
| JP2020503300A (ja) * | 2016-12-16 | 2020-01-30 | ヤンセン ファーマシューティカ エヌ．ベー． | 二環式ｏｇａ阻害剤化合物 |
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| WO2020039029A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Spiro compounds as glycosidase inhibitors |
| WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
| EP3969639A1 (en) | 2019-05-13 | 2022-03-23 | Ecolab Usa Inc. | 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor |
| TW202220992A (zh) | 2020-08-05 | 2022-06-01 | 匈牙利商羅特格登公司 | 具藥理活性之經雜環取代的吡唑并〔１，５－ａ〕嘧啶衍生物 |
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