CN106456609A - 作为irak4抑制剂的取代的吲唑化合物 - Google Patents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3017/CHE/2014 | 2014-06-20 | ||
| IN3017CH2014 | 2014-06-20 | ||
| PCT/IB2015/054620 WO2015193846A1 (en) | 2014-06-20 | 2015-06-19 | Substituted indazole compounds as irak4 inhibitors |
Publications (1)
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| CN106456609A true CN106456609A (zh) | 2017-02-22 |
Family
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Family Applications (1)
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| CN201580033142.0A Pending CN106456609A (zh) | 2014-06-20 | 2015-06-19 | 作为irak4抑制剂的取代的吲唑化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20170152263A1 (https=) |
| EP (1) | EP3157521A4 (https=) |
| JP (1) | JP2017518348A (https=) |
| KR (1) | KR20170016500A (https=) |
| CN (1) | CN106456609A (https=) |
| AU (1) | AU2015275730A1 (https=) |
| BR (1) | BR112016029853A2 (https=) |
| CA (1) | CA2952188A1 (https=) |
| CU (1) | CU20160188A7 (https=) |
| EA (1) | EA201692418A1 (https=) |
| HK (1) | HK1231411A1 (https=) |
| IL (1) | IL249345A0 (https=) |
| MX (1) | MX2016017147A (https=) |
| PH (1) | PH12016502382A1 (https=) |
| SG (1) | SG11201610009XA (https=) |
| WO (1) | WO2015193846A1 (https=) |
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| CN109152771A (zh) * | 2016-06-01 | 2019-01-04 | 拜耳医药股份有限公司 | 2-取代的吲唑用于治疗和预防自身免疫疾病的用途 |
| CN110770229A (zh) * | 2017-06-21 | 2020-02-07 | 豪夫迈·罗氏有限公司 | 作为irak4调节剂的苯并呋喃化合物 |
| CN110833559A (zh) * | 2018-08-15 | 2020-02-25 | 广西梧州制药（集团）股份有限公司 | 吡唑并嘧啶衍生物在治疗急性肺损伤致肺纤维化的用途 |
| CN111225911A (zh) * | 2017-10-31 | 2020-06-02 | 库里斯公司 | 用于治疗血液病的化合物和组合物 |
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| CN112480101A (zh) * | 2019-09-12 | 2021-03-12 | 中国科学院上海药物研究所 | 一类irak4激酶抑制剂及其制备和应用 |
| CN112654604A (zh) * | 2018-09-06 | 2021-04-13 | 浙江海正药业股份有限公司 | 7-取代吲唑类衍生物及其制备方法和其在医药上的用途 |
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| WO2022135338A1 (zh) * | 2020-12-25 | 2022-06-30 | 南京明德新药研发有限公司 | 酰胺噁唑类化合物 |
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| UY36660A (es) | 2015-04-30 | 2016-11-30 | Bayer Pharma AG | Combinaciones de inhibidores de irak4 |
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| BR112021026517A2 (pt) | 2019-06-28 | 2022-05-10 | Kymera Therapeutics Inc | Degradadores de irak e usos dos mesmos |
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| US20230107927A1 (en) | 2020-02-28 | 2023-04-06 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
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| KR20240004476A (ko) | 2021-04-08 | 2024-01-11 | 쿠리스 인코퍼레이션 | 암 치료를 위한 병용 요법 |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108473498B (zh) * | 2015-12-22 | 2021-11-02 | 豪夫迈·罗氏有限公司 | 作为IRAK4调节剂的吡唑并[1,5a]嘧啶衍生物 |
| CN108473498A (zh) * | 2015-12-22 | 2018-08-31 | 豪夫迈·罗氏有限公司 | 作为IRAK4调节剂的吡唑并[1,5a]嘧啶衍生物 |
| CN109152771A (zh) * | 2016-06-01 | 2019-01-04 | 拜耳医药股份有限公司 | 2-取代的吲唑用于治疗和预防自身免疫疾病的用途 |
| CN109152771B (zh) * | 2016-06-01 | 2022-07-19 | 拜耳医药股份有限公司 | 2-取代的吲唑用于治疗和预防自身免疫疾病的用途 |
| CN110770229A (zh) * | 2017-06-21 | 2020-02-07 | 豪夫迈·罗氏有限公司 | 作为irak4调节剂的苯并呋喃化合物 |
| CN111225911A (zh) * | 2017-10-31 | 2020-06-02 | 库里斯公司 | 用于治疗血液病的化合物和组合物 |
| CN111225911B (zh) * | 2017-10-31 | 2023-09-01 | 库里斯公司 | 用于治疗血液病的化合物和组合物 |
| CN112236429A (zh) * | 2018-04-05 | 2021-01-15 | 默克专利有限公司 | 用作ii型irak抑制剂的杂芳基化合物及其用途 |
| CN110833559A (zh) * | 2018-08-15 | 2020-02-25 | 广西梧州制药（集团）股份有限公司 | 吡唑并嘧啶衍生物在治疗急性肺损伤致肺纤维化的用途 |
| CN112654604A (zh) * | 2018-09-06 | 2021-04-13 | 浙江海正药业股份有限公司 | 7-取代吲唑类衍生物及其制备方法和其在医药上的用途 |
| CN112654604B (zh) * | 2018-09-06 | 2023-05-16 | 浙江海正药业股份有限公司 | 7-取代吲唑类衍生物及其制备方法和其在医药上的用途 |
| CN114127075A (zh) * | 2019-07-18 | 2022-03-01 | 百时美施贵宝公司 | 可用作IRAK4抑制剂的吡唑并[3,4-d]吡咯并[1,2-b]哒嗪基化合物 |
| CN114127075B (zh) * | 2019-07-18 | 2024-05-14 | 百时美施贵宝公司 | 可用作IRAK4抑制剂的吡唑并[3,4-d]吡咯并[1,2-b]哒嗪基化合物 |
| CN112480101A (zh) * | 2019-09-12 | 2021-03-12 | 中国科学院上海药物研究所 | 一类irak4激酶抑制剂及其制备和应用 |
| WO2021047677A1 (zh) * | 2019-09-12 | 2021-03-18 | 中国科学院上海药物研究所 | 一类irak4激酶抑制剂及其制备和应用 |
| CN115867562A (zh) * | 2020-05-08 | 2023-03-28 | 乔治穆内有限责任公司 | Akt3调节剂 |
| CN116529250A (zh) * | 2020-08-04 | 2023-08-01 | 奥里吉恩肿瘤学有限公司 | 作为smarca2和/或smarca4降解剂的6-取代的哒嗪化合物 |
| WO2022135338A1 (zh) * | 2020-12-25 | 2022-06-30 | 南京明德新药研发有限公司 | 酰胺噁唑类化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20170152263A1 (en) | 2017-06-01 |
| EP3157521A1 (en) | 2017-04-26 |
| SG11201610009XA (en) | 2017-01-27 |
| HK1231411A1 (zh) | 2017-12-22 |
| WO2015193846A1 (en) | 2015-12-23 |
| KR20170016500A (ko) | 2017-02-13 |
| CU20160188A7 (es) | 2017-06-05 |
| IL249345A0 (en) | 2017-02-28 |
| PH12016502382A1 (en) | 2017-02-20 |
| JP2017518348A (ja) | 2017-07-06 |
| EP3157521A4 (en) | 2018-02-14 |
| MX2016017147A (es) | 2017-06-07 |
| EA201692418A1 (ru) | 2017-04-28 |
| CA2952188A1 (en) | 2015-12-23 |
| AU2015275730A1 (en) | 2016-12-15 |
| BR112016029853A2 (pt) | 2017-08-22 |
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