CN106389205B - A kind of mouthwash containing sodium copper chlorophyllin - Google Patents
A kind of mouthwash containing sodium copper chlorophyllin Download PDFInfo
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- CN106389205B CN106389205B CN201610928857.9A CN201610928857A CN106389205B CN 106389205 B CN106389205 B CN 106389205B CN 201610928857 A CN201610928857 A CN 201610928857A CN 106389205 B CN106389205 B CN 106389205B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
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Abstract
The invention belongs to household chemicals technical field, and in particular to a kind of mouthwash containing sodium copper chlorophyllin.The mouthwash containing sodium copper chlorophyllin includes：Jasmine flower extract 1.5~2.5%, Lotus Leafextract 0.5~1.5%, sodium copper chlorophyllin 0.01~0.3%, APG 0.5~1.5%, Tween 80 0.4~1.0%, NMF 5~10%, sweetener 0.01~0.1%, preservative 0.01~0.1%, ethanol 5~10%, surplus is water.The cleanable oral cavity of mouthwash of the present invention and fresh breath, while effectively alleviating gingivitis, bleeding gums；And mouthwash stable system of the present invention, preparation method is simple, can be applicable.
Description
Technical field
The invention belongs to household chemicals technical field, and in particular to a kind of mouthwash containing sodium copper chlorophyllin.
Background technology
With the development and the continuous improvement of living standard of economic society, the oral health consciousness of people is greatly enhanced, mouth
Chamber care product also gradually develops into a variety of care products such as toothpaste, tooth patch, mouthwash by single toothpaste.People consume purpose
Also it is changed into the health care and prevention in oral cavity by single oral cleaning.Mouthwash is as a kind of oral health care product, because its is convenient
Property is gradually widely used in people's daily life.
Mouthwash basic function is cleaning tooth, and fresh breath reaches the purpose for keeping oral cleaning, and with people
The transformation of purpose is consumed, more requirements are proposed to mouthwash, some auxiliary prevention oral cavity diseases are also add in addition to cleaning the teeth
Disease, the function of having nursing role to oral cavity.In recent years, the rise of natural and environmental protection concept, uses natural drug, particularly China
Chinese herb medicine is applied in mouthwash the emphasis for being Developing and research and development as active component.
Meanwhile, in order that mouthwash has good outward appearance, promote people's consumption, it will usually added in mouthwash edible
Pigment, conventional food coloring is phyllins class at present, mainly includes chlorophyll paste and sodium copper chlorophyllin.Pasty state
Chlorophyll is chlorophyll magnesium sodium salt, and it is insoluble in water, and stability is also poor, is easily caused product discoloration, therefore application is fewer and fewer.
Sodium copper chlorophyllin (CAS：Water solubility and stability 65963-40-8) is all good compared with chlorophyll magnesium sodium salt, its strong coloring force, color
Pool is beautiful, but still poor to light, heat endurance, and its aqueous solution is in emerald green clear liquid, when with the presence of calcium ion or molten
Liquid pH value then has Precipitation when being less than 6, strongly limit the application of sodium copper chlorophyllin；And it is used for because structure limits it
The effect of dyeing, and fraction of anti-inflammatory, deodorization, anastalsis are primarily served in oral care implement.Chinese patent application
CN103751031A discloses a kind of gargle containing antibacterial peptide and sodium copper chlorophyllin, and it includes antibacterial peptide, chlorophyll copper sodium
Salt, menthol, gallic acid, borneol, ethanol and essence.But its do not have well solve sodium copper chlorophyllin to light, heat
Instability problem, also without the anti-inflammatory of performance sodium copper chlorophyllin, deodorization, anastalsis well.
The content of the invention
In order to overcome the deficiencies in the prior art, it is an object of the invention to provide a kind of gargling containing sodium copper chlorophyllin
Water, cleanable oral cavity and fresh breath, while effectively alleviating gingivitis, bleeding gums, and improve the steady of sodium copper chlorophyllin
It is qualitative.
To achieve these goals, technical scheme is as follows：
A kind of mouthwash containing sodium copper chlorophyllin, is made up of the component of following percentage by weight meter：Jasmine is extracted
Thing 1.5~2.5%, Lotus Leafextract 0.5~1.5%, sodium copper chlorophyllin 0.01~0.3%, APG 0.5~1.5%,
Tween-80 0.4~1.0%, NMF 5~10%, sweetener 0.01~0.1%, preservative 0.01~0.1%, ethanol 5~
10%, surplus is water.
As the preferred embodiment of the present invention, the mouthwash containing sodium copper chlorophyllin is by following percentage by weight
The component composition of meter：Jasmine flower extract 2.0%, Lotus Leafextract 1.0%, sodium copper chlorophyllin 0.1%, APG
1.0%th, Tween-80 0.8%, NMF 8%, sweetener 0.06%, preservative 0.05%, ethanol 6%, surplus is water.
Further, the preparation method of the jasmine flower extract is as follows：Jasmine is taken, 3~5 times of amounts of its weight are added
Water, 2~3h of heating and refluxing extraction, filtering, filtrate is in the leaching that vacuum-concentrcted to relative density at 60 DEG C is 1.10~1.20
Cream, the vacuum dried obtained jasmine flower extract of medicinal extract.
Further, the preparation method of the Lotus Leafextract is as follows：Lotus leaf is taken, the water of 3~5 times of amounts of its weight is added,
2~3h of heating and refluxing extraction, filtering, filtrate vacuum-concentrcted to relative density at 60 DEG C be 1.10~1.20 medicinal extract,
The vacuum dried obtained Lotus Leafextract of medicinal extract.
Further, the NMF is at least one of glycerine, sorbierite and propane diols.
Further, the sweetener is at least one of xylitol, D-sorbite and Aspartame.
Further, the preservative is epsilon-polylysine.
Accordingly, the preparation method of the above-mentioned mouthwash containing sodium copper chlorophyllin specifically includes following steps：
S1, Jasmine is taken, add the water of 3~5 times of amounts of its weight, 2~3h of heating and refluxing extraction, filtering, filtrate is in vacuum
The medicinal extract that relative density at 60 DEG C is 1.10~1.20 is concentrated under reduced pressure into, the vacuum dried obtained jasmine flower extract of medicinal extract is standby
With；
S2, lotus leaf is taken, add the water of 3~5 times of amounts of its weight, 2~3h of heating and refluxing extraction, filtering, filtrate subtracts in vacuum
Pressure is concentrated into the medicinal extract that relative density at 60 DEG C is 1.10~1.20, and the vacuum dried obtained Lotus Leafextract of medicinal extract is standby；
S3, the jasmine flower extract for taking formula ratio, Lotus Leafextract, sodium copper chlorophyllin, APG, Tween-80, guarantor
Humectant, sweetener, preservative, the mixing of second alcohol and water, stir, the mouthwash containing sodium copper chlorophyllin are made.
In technical solution of the present invention, the jasmine flower extract is spent by drying for Oleaceae gelsemium shrub plant jasmine
It is made through water extraction, Lotus Leafextract is made by the dried leaf of nymphaeaceae plant lotus through water extraction.
Sodium copper chlorophyllin has certain anti-inflammatory, deodorization, an anastalsis, but is due to that its consumption in mouthwash is low,
So action effect is not obvious.Jasmine and lotus leaf have certain anti-inflammation, clearing heat and detoxicating effect, and all with order
The delicate fragrance of people's pleasure, inventor is tentatively gargled as raw material using Jasmine and lotus leaf with sodium copper chlorophyllin compounding to improve
Anti-inflammatory, deodorization and the anastalsis of saliva, for the stabilization of guarantee system, the present invention using Jasmine and lotus leaf water extract with
Sodium copper chlorophyllin is compounded, by constantly studying and testing, present invention determine that jasmine flower extract, Lotus Leafextract
With the consumption proportion of sodium copper chlorophyllin, lower mouthwash of the present invention is matched herein to be had substantially to gingivitis, bleeding gums and halitosis
Mitigation, and allow people surprisingly jasmine flower extract, the combination of Lotus Leafextract can significantly improve chlorophyll
The stability of copper sodium so that mouthwash of the present invention remains in that beautiful after being placed 18 months under the conditions of room temperature, natural lighting
Emerald green clear state.
Therefore, compared with prior art, advantage of the invention is that：
(1) mouthwash of the invention containing sodium copper chlorophyllin is with jasmine flower extract, Lotus Leafextract and copper chlorophyll
Sodium salt is compounded as active component, cleanable oral cavity and fresh breath, is asked while effectively alleviating the oral cavities such as gingivitis, bleeding gums
Topic.
(2) mouthwash containing sodium copper chlorophyllin of the invention is in beautiful emerald green, and system clear, steady
Fixed, safety, with Jasmine delicate fragrance, without extra addition essence；The preparation method of mouthwash of the present invention is simple simultaneously, and condition can
Control, process stabilizing, can industrialized production, be conducive to popularization and application.
Embodiment
The present invention is further described below by way of embodiment, but the present invention is not limited only to following examples.
In the scope of the present invention or not departing from present disclosure, in spirit and scope, to Golden flower moisturizing of the present invention essence
Magnificent liquid is suitably modified, replaces effect identical component, it will become apparent to those skilled in the art that they are all
It is deemed to be included within the scope of the present invention.
Embodiment 1, the mouthwash of the invention containing sodium copper chlorophyllin
Formula：Jasmine flower extract 1.5kg, Lotus Leafextract 0.5kg, sodium copper chlorophyllin 0.01kg, APG
0.5kg, Tween-80 0.4kg, glycerine 5kg, xylitol 0.01kg, epsilon-polylysine 0.01kg, ethanol 5kg, deionized water are mended
Sufficient 100kg.
Preparation method：
S1, Jasmine is taken, add the water of 3 times of amounts of its weight, heating and refluxing extraction 2h, filtering, filtrate is dense in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.10 is reduced to, the vacuum dried obtained jasmine flower extract of medicinal extract is standby；
S2, lotus leaf is taken, add the water of 3 times of amounts of its weight, heating and refluxing extraction 2h, filtering, filtrate is in vacuum-concentrcted
Relative density is 1.10 medicinal extract to 60 DEG C, and the vacuum dried obtained Lotus Leafextract of medicinal extract is standby；
It is S3, the jasmine flower extract for taking formula ratio, Lotus Leafextract, sodium copper chlorophyllin, APG, Tween-80, sweet
Oil, xylitol, epsilon-polylysine, the mixing of second alcohol and water, stir, the mouthwash containing sodium copper chlorophyllin are made.
Embodiment 2, the mouthwash of the invention containing sodium copper chlorophyllin
Formula：Jasmine flower extract 2.5kg, Lotus Leafextract 1.5kg, sodium copper chlorophyllin 0.3kg, APG
1.5kg, Tween-80 1.0kg, sorbierite 10kg, D-sorbite 0.1kg, epsilon-polylysine 0.1kg, ethanol 10kg, deionization
Water supplies 100kg.
Preparation method：
S1, Jasmine is taken, add the water of 5 times of amounts of its weight, heating and refluxing extraction 3h, filtering, filtrate is dense in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.20 is reduced to, the vacuum dried obtained jasmine flower extract of medicinal extract is standby；
S2, lotus leaf is taken, add the water of 5 times of amounts of its weight, heating and refluxing extraction 3h, filtering, filtrate is in vacuum-concentrcted
Relative density is 1.20 medicinal extract to 60 DEG C, and the vacuum dried obtained Lotus Leafextract of medicinal extract is standby；
S3, the jasmine flower extract for taking formula ratio, Lotus Leafextract, sodium copper chlorophyllin, APG, Tween-80, mountain
Pears alcohol, D-sorbite, epsilon-polylysine, the mixing of second alcohol and water, stir, the mouthwash containing sodium copper chlorophyllin are made.
Embodiment 3, the mouthwash of the invention containing sodium copper chlorophyllin
Formula：Jasmine flower extract 1.5kg, Lotus Leafextract 1.5kg, sodium copper chlorophyllin 0.2kg, APG
0.5kg, Tween-80 1.0kg, propane diols 6kg, Aspartame 0.1kg, epsilon-polylysine 0.05kg, ethanol 8kg, deionized water
Supply 100kg.
Preparation method：
S1, Jasmine is taken, add the water of 3 times of amounts of its weight, heating and refluxing extraction 3h, filtering, filtrate is dense in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.10 is reduced to, the vacuum dried obtained jasmine flower extract of medicinal extract is standby；
S2, lotus leaf is taken, add the water of 5 times of amounts of its weight, heating and refluxing extraction 2h, filtering, filtrate is in vacuum-concentrcted
Relative density is 1.20 medicinal extract to 60 DEG C, and the vacuum dried obtained Lotus Leafextract of medicinal extract is standby；
S3, the jasmine flower extract for taking formula ratio, Lotus Leafextract, sodium copper chlorophyllin, APG, Tween-80, third
Glycol, Aspartame, epsilon-polylysine, the mixing of second alcohol and water, stir, the mouthwash containing sodium copper chlorophyllin are made.
Embodiment 4, the mouthwash of the invention containing sodium copper chlorophyllin
Formula：Jasmine flower extract 2.0kg, Lotus Leafextract 1.0kg, sodium copper chlorophyllin 0.1kg, APG
1.0kg, Tween-80 0.8kg, sorbierite 8kg, xylitol 0.06kg, epsilon-polylysine 0.05kg, ethanol 6kg, deionized water
Supply 100kg.
Preparation method：
S1, Jasmine is taken, add the water of 4 times of amounts of its weight, heating and refluxing extraction 2h, filtering, filtrate is dense in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.20 is reduced to, the vacuum dried obtained jasmine flower extract of medicinal extract is standby；
S2, lotus leaf is taken, add the water of 4 times of amounts of its weight, heating and refluxing extraction 2h, filtering, filtrate is in vacuum-concentrcted
Relative density is 1.20 medicinal extract to 60 DEG C, and the vacuum dried obtained Lotus Leafextract of medicinal extract is standby；
S3, the jasmine flower extract for taking formula ratio, Lotus Leafextract, sodium copper chlorophyllin, APG, Tween-80, mountain
Pears alcohol, xylitol, epsilon-polylysine, the mixing of second alcohol and water, stir, the mouthwash containing sodium copper chlorophyllin are made.
Comparative example 1,
Formula：Jasmine flower extract 3.0kg, sodium copper chlorophyllin 0.15kg, APG 1.0kg, Tween-80
0.8kg, sorbierite 8kg, xylitol 0.06kg, epsilon-polylysine 0.05kg, ethanol 6kg, deionized water supply 100kg.Prepare
Method reference implementation example 4.
Compared with Example 4, this comparative example is free of Lotus Leafextract, and improves jasmine flower extract and copper chlorophyll
Sodium salt consumption, but both constant rates.
Comparative example 2,
Formula：Lotus Leafextract 3.0kg, sodium copper chlorophyllin 0.3kg, APG 1.0kg, Tween-80 0.8kg, mountain
Pears alcohol 8kg, xylitol 0.06kg, epsilon-polylysine 0.05kg, ethanol 6kg, deionized water supply 100kg.Preparation method is referred to
Embodiment 4.
Compared with Example 4, this comparative example is free of jasmine flower extract, and improves Lotus Leafextract and copper chlorophyll
Sodium salt consumption, but both constant rates.
Comparative example 3,
Formula：Jasmine flower extract 2.0kg, Lotus Leafextract 1.0kg, APG 1.0kg, Tween-80 0.8kg, mountain
Pears alcohol 8kg, xylitol 0.06kg, epsilon-polylysine 0.05kg, ethanol 6kg, deionized water supply 100kg.Preparation method is referred to
Embodiment 4.
Compared with Example 4, this comparative example is free of sodium copper chlorophyllin.
Comparative example 4,
Formula：Sodium copper chlorophyllin 0.1kg, APG 1.0kg, Tween-80 0.8kg, sorbierite 8kg, xylitol
0.06kg, epsilon-polylysine 0.05kg, ethanol 6kg, deionized water supply 100kg.Preparation method reference implementation example 4.
Compared with Example 4, this comparative example is free of jasmine flower extract and Lotus Leafextract.
The irritation test of test example one, the mouthwash of the invention containing sodium copper chlorophyllin
Eye irritation is examined：Healthy adult white rabbit 3 (eyes have been checked) is selected, the branch hole of rabbit one is gently pulled open
The palpebra inferior of eyeball, tested material 0.1mL (2 drop) is instilled in conjunctival sac, upper and lower eyelid is passively closed 1s, to prevent tested material
Lose.Opposite side eyes are not handled as own control.Observed after 1h with magnifying glass, as a result see the table below 1.
The mouthwash excitant contrast experiment of table 1
From upper table 1, the mouthwash of the invention containing sodium copper chlorophyllin is nonirritant.
The application effect of test example two, the mouthwash of the invention containing sodium copper chlorophyllin
(1) to the remission effect of gingivitis, bleeding gums
Invite and suffer from gingivitis, the people of volunteer 96 of bleeding gums, be randomly divided into 8 groups, every group of 12 people try out implement respectively
Mouthwash made from example 1~4, comparative example 1~4, sooner or later each to use 1 time, each 20ml contains 30s~60s.As a result 2 be see the table below.
Table 2 uses gingivitis, bleeding gums evaluation result before and after mouthwash
Note：The site that BOP% has bleeding after being examined for spy accounts for the percentage in the total site of full mouth.
From upper table 2：The gingivitis bleeding of mouthwash of the embodiment of the present invention 1~4 containing sodium copper chlorophyllin refers to
Mark BOP% has clear improvement, and shows that mouthwash of the present invention has functions that more apparent improvement gingivitis, bleeding gums；Wherein implement
The BOP% target improvements of example 4 are most obvious, are highly preferred embodiment of the present invention.Comparative example 1 is free of Lotus Leafextract, and comparative example 2 is not
Containing jasmine flower extract, comparative example 3 is free of sodium copper chlorophyllin, and comparative example 4 only contains sodium copper chlorophyllin, and its mouthwash is to gum
Inflammation bleeding index BOP% is not improved effect.
(2) halitosis effect is removed
Not yet there is deodorization standard in China, borrows the standard of European Union SCCNFP direct smell method, by halitosis point Pyatyi.One
Level, no halitosis；Two grades of very slight halitosis；The slight halitosis of three-level；Level Four moderate halitosis；The strong halitosis of Pyatyi.
80 volunteers are invited, 8 groups are randomly divided into, embodiment 1~4, mouthwash made from comparative example 1~4 are tried out respectively.
The preceding 8 groups of volunteers of experiment are drunk into 150ml beer, a garlic fried shredded pork and two small steamed buns.Gargled after the meal with cold boiling water, by commenting
Fragrant teacher detects oral peculiar smell, is used as benchmark.After 1 hour, with above-mentioned mouthwash 30 seconds, rest 30 minutes.Again by commenting fragrant teacher
Halitosis level is evaluated, using result as the evaluation result except halitosis, 3 are as a result see the table below.
Each mouthwash deodorizing effect of table 3 is evaluated
The computational methods of halitosis integration：Σ stinks rank × number of cases.
From upper table 3, halitosis integration is higher after the meal, and each group halitosis integrates indifference；Using the embodiment of the present invention 1~
After 4 mouthwashes, halitosis integration has obvious reduction, shows that mouthwash of the present invention effectively removes halitosis, the halitosis of removing of wherein embodiment 4 is imitated
Fruit is the most obvious, is highly preferred embodiment of the present invention.And comparative example 1~4 remove halitosis DeGrain.
The stability of test example three, the mouthwash of the invention containing sodium copper chlorophyllin
1st, test material：Mouthwash made from embodiment 1~4, comparative example 1~4.
2nd, test method：Long term test is carried out to above-mentioned mouthwash, the outward appearance and color and luster of mouthwash is observed.
3rd, result of the test：Result of the test is as shown in table 4 below.
The long-term test results of each mouthwash of table 4
As shown in Table 4：Mouthwash of the embodiment of the present invention 1~4 containing sodium copper chlorophyllin is in room temperature, natural lighting condition
It is lower place 18 months after remain in that clear and beautiful emerald green, and 1~4 mouthwash of comparative example is begun to after 3 months
There is different degrees of muddy or precipitation, oxidative phenomena, reflect mouthwash of the present invention with higher stability, can be effective
Holding mouthwash organoleptic indicator, extend product shelf-life.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (6)
1. a kind of mouthwash containing sodium copper chlorophyllin, it is characterised in that be made up of the component of following percentage by weight meter：Jasmine
Jasmine flower extract 1.5~2.5%, Lotus Leafextract 0.5~1.5%, sodium copper chlorophyllin 0.01~0.3%, APG 0.5
~1.5%, Tween-80 0.4~1.0%, NMF 5~10%, sweetener 0.01~0.1%, preservative 0.01~0.1%,
Ethanol 5~10%, surplus is water；
The preparation method of the jasmine flower extract is as follows：Jasmine is taken, the water of 3~5 times of amounts of its weight is added, is heated to reflux carrying
2~3h is taken, is filtered, filtrate is in the medicinal extract that vacuum-concentrcted to relative density at 60 DEG C is 1.10~1.20, and medicinal extract is through vacuum
Dry obtained jasmine flower extract；
The preparation method of the Lotus Leafextract is as follows：Lotus leaf is taken, the water of 3~5 times of amounts of its weight, heating and refluxing extraction 2 is added
~3h, filtering, filtrate is in the medicinal extract that vacuum-concentrcted to relative density at 60 DEG C is 1.10~1.20, and medicinal extract is vacuum dried
Lotus Leafextract is made.
2. the mouthwash as claimed in claim 1 containing sodium copper chlorophyllin, it is characterised in that by following percentage by weight meter
Component is constituted：Jasmine flower extract 2.0%, Lotus Leafextract 1.0%, sodium copper chlorophyllin 0.1%, APG 1.0%, tell
Temperature -80 0.8%, NMF 8%, sweetener 0.06%, preservative 0.05%, ethanol 6%, surplus is water.
3. the mouthwash containing sodium copper chlorophyllin as claimed in claim 1 or 2, it is characterised in that the NMF be glycerine,
At least one of sorbierite and propane diols.
4. the mouthwash as claimed in claim 1 or 2 containing sodium copper chlorophyllin, it is characterised in that the sweetener is xylose
At least one of alcohol, D-sorbite and Aspartame.
5. the mouthwash containing sodium copper chlorophyllin as claimed in claim 1 or 2, it is characterised in that the preservative is ε-poly-
Lysine.
6. the preparation method of the mouthwash containing sodium copper chlorophyllin as claimed in claim 1 or 2, it is characterised in that including with
Lower step：
S1, Jasmine is taken, add the water of 3~5 times of amounts of its weight, 2~3h of heating and refluxing extraction, filtering, filtrate is in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.10~1.20 is concentrated into, the vacuum dried obtained jasmine flower extract of medicinal extract is standby；
S2, lotus leaf is taken, add the water of 3~5 times of amounts of its weight, 2~3h of heating and refluxing extraction, filtering, filtrate is dense in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.10~1.20 is reduced to, the vacuum dried obtained Lotus Leafextract of medicinal extract is standby；
S3, take formula ratio jasmine flower extract, Lotus Leafextract, sodium copper chlorophyllin, APG, Tween-80, NMF,
Sweetener, preservative, the mixing of second alcohol and water, stir, the mouthwash containing sodium copper chlorophyllin are made.
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| CN107149571A (en) * | 2017-04-17 | 2017-09-12 | 廖华勇 | Jasmin general type mouthwash |
| CN107308058A (en) * | 2017-07-28 | 2017-11-03 | 张可池 | A kind of mouthwash containing sterculia nobilis's berry extract |
| CN112754980A (en) * | 2021-02-26 | 2021-05-07 | 西南医科大学附属中医医院 | Toothpaste with antibacterial effect and preparation method thereof |
| CN116211768A (en) * | 2023-03-17 | 2023-06-06 | 合肥贝壳派创新科技有限公司 | Tremella polysaccharide tooth cleaning care solution and preparation process thereof |
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