CN105213211A - A kind of collutory containing folic acid and preparation method thereof - Google Patents
A kind of collutory containing folic acid and preparation method thereof Download PDFInfo
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- CN105213211A CN105213211A CN201410301551.1A CN201410301551A CN105213211A CN 105213211 A CN105213211 A CN 105213211A CN 201410301551 A CN201410301551 A CN 201410301551A CN 105213211 A CN105213211 A CN 105213211A
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Abstract
The invention provides a kind of collutory containing folic acid, this collutory contains folic acid, zinc citrate, Mentholum, sodium ascorbate, sodium bicarbonate, sodium copper chlorophllin, potassium sorbate, sorbitol or sorbose, deionized water.This collutory additive, all from raw-food material, safely, has no side effect, and has the effect alleviated pregnancy and puerperium gingivitis, gingival hemorrhage and pre-antiplaque and formed, can be used as pregnancy and puerperium oral cavity cleaning assistant product life-time service.The present invention also provides this to contain the preparation method of the collutory of folic acid, and this preparation method is: folic acid, Mentholum, sodium ascorbate, zinc citrate, sodium bicarbonate, sodium copper chlorophllin, potassium sorbate, sorbitol or sorbose and deionized water are produced by the method be uniformly mixed.
Description
Technical field
The invention belongs to household chemicals field, be specifically related to a kind of collutory containing folic acid and preparation method thereof, it uses crowd to be trimester of pregnancy and puerperal women.
Background technology
Trimester of pregnancy gingivitis be trimester of pregnancy occur the peculiar symptom in oral cavity, also referred to as pregnancy gingivitis.According to statistics, conceived women's incidence rate about 50%.Clinical symptoms is dental pattern gingivitis, and especially interdental papilla is swollen has obviously, and color is dark red, shinny, soft, and severe patient may have ulcer and pseudomembrane to be formed.And have slight pain to occur.Trimester of pregnancy, gingivitis generally occurred for 2 to 4 months after pregnancy, and childbirth then disappears.If existing gingivitis exists before gestation, then symptom can be made to aggravate.Therefore, there is the anemia of pregnant woman of advanced symptoms, oral health care must be carried out in time.
Gestation also can affect diet, the sleep habit of anemia of pregnant woman, and conceived rear anemia of pregnant woman's diet number of times generally can increase, dietary amount also can increase.Food debris is easy to corruption, produces acid, the food crumbs of caulked in teeth space in oral environment, not only serious stimulation is produced to periodontal tissue, but also can supply nutrients for bacterial reproduction, destroy tooth and periodontal tissue, increase the weight of the formation of pregnancy period gingivitis and dental plaque.But it is namely inconvenient, also unrealistic to brush teeth at any time after the meal.Therefore anemia of pregnant woman at once uses collutory cleaning oral cavity after diet, effectively can prevent the generation of pregnancy period oral disease.
Have various collutory in the market, the special collutory of Pregnant Women reaches corresponding object by adding various ingredient, or adding ingredient does not have the effect improving pregnancy period oral health.
Folic acid (FolicAcid) be also FA, is a kind of water soluble vitamins, and be present in little of virus, antibacterial, greatly in all biosystems of the mankind, folic acid is a kind of conventional supplementary.Folic acid is the indispensable nutrient of embryo growth and development.Anemia of pregnant woman lacks folic acid and likely causes occurring under-weight, harelip, heart defect etc. during fetal birth.If lack folic acid at conceived in 3 months, fetal neural tube developmental defect can be caused, and cause deformity.Therefore, prepare conceived women, can just start to take 400 folic every day before pregnancy.
In addition, have clinical research to find, pregnancy duration uses and also can reduce trimester of pregnancy gingival index containing the dental care products of folic acid, prevention of gingivitis, alleviates gingival hemorrhage.
Since first Hanke in 1940 finds that zinc salt has antiplaque effect, scholars create great interest to this, a large amount of experimentatioies and clinical observation are carried out, confirm zinc antiplaque effect in vivo and in vitro, the effect of the zinc compound anti-plaque in toothpaste and collutory generally gains recognition.Be usually used at present in oral cleaning nursing article containing zinc complex zinc chloride, zinc citrate has well anti-plaque effect.
Summary of the invention
For pregnancy and puerperium oral health issue, the present invention intends providing a kind of folic acid collutory being main active with folic acid and zinc citrate.
This collutory consists of the following composition: folic acid, zinc citrate, Mentholum, sodium ascorbate, sodium bicarbonate, sodium copper chlorophllin, potassium sorbate, sorbitol or sorbose, deionized water.
The each composition used in this collutory is raw-food material, all meets the existing legal production of state food raw material and prescription.
The mass fraction of each component of this collutory is folic acid 0.1-1 part, zinc citrate 1-10 part, Mentholum 0.5-5 part, sodium ascorbate 1.5-6 part, sodium bicarbonate 0.1-3 part, sodium copper chlorophllin 0.01-0.2 part, potassium sorbate 3.5-8 part, sorbitol or sorbose 5-20 part, deionized water 946.80-988.29 part.
The preparation process of collutory of the present invention is folic acid, Mentholum, sodium ascorbate, zinc citrate, sodium bicarbonate, sodium copper chlorophllin, potassium sorbate, sorbitol or sorbose and deionized water are produced by the method be uniformly mixed.
The invention provides the purposes of above-mentioned collutory, this collutory can be used for the problem alleviating pregnancy and puerperium gingivitis, gingival hemorrhage, can also be formed by antiplaque in advance simultaneously, can be used as pregnancy and puerperium oral cavity cleaning assistant product life-time service.
When using collutory involved in the present invention, according to individual mouth healthy condition, suitably can reduce or increase consumption, can better improve pregnancy period gingivitis, gingival hemorrhage, protect the health of one's mouth.
The materials safety that the present invention uses, is particularly suitable for pregnancy and puerperium women, under positive usual amounts uses to mother and fetus all without health hazard.The refine of this mouthwash formula, definite effect, act on strong points, constant product quality, can widely use for a long time.
Detailed description of the invention
Below that Binding experiment further illustrates of the present invention.
1, raw material and the consumption (g) of 1Kg collutory is produced in embodiment 1-5
2, preparation method
Folic acid, Mentholum, sodium ascorbate, zinc citrate, sodium bicarbonate, sodium copper chlorophllin, potassium sorbate, sorbitol or sorbose are mixed by the method stirred with deionized water.
Stop stirring, sampling detects qualified rear subpackage and makes.
3, this collutory is for alleviating pregnancy and puerperium gingivitis, gingival hemorrhage, and the effect that pre-antiplaque is formed also obtains the confirmation of clinical research, and result of study is as follows:
3.1 alleviate gingivitis, gingival hemorrhage
Matched group experimenter uses the collutory not containing folic acid and zinc citrate, and experimental group experimenter uses the collutory that the present invention relates to.Distribute the one in 2 kinds of collutory to experimenter, require to use the collutory of regulation to gargle, every day 2 times, each 20mL rinsing the mouth 30s.
Use gingivitis, gingival hemorrhage evaluation result before and after folic acid collutory
Note: BOP% has hemorrhage site to account for the percent in the total site of full mouth after spy is examined.
Clinical effectiveness shows, experimental group has clear improvement compared with the hemorrhage index of the gingivitis of matched group experimenter, and folic acid collutory has and significantly improves gingival hemorrhage effect.
3.2 pre-antiplaques are formed
Adopt the Turesky plaque index of Quigley-Hein improvement to evaluate supragingival plaque, scoring criteria is as follows: 0-is without bacterial plaque; The bacterial plaque that 1-neck portion marginal existence is dispersed in; The thin bacterial plaque band (reaching 1mm wide) of the visible continuous print in 2-neck edge; 3-neck portion bacterial plaque band is greater than 1mm but is less than 1/3 of facing; 4-bacterial plaque covers 1/3 ~ 2/3 of facing; 5-bacterial plaque covers facing more than 2/3.Calculate the average of each experimenter's plaque index.
Matched group experimenter uses the collutory not containing folic acid and zinc citrate, and experimental group experimenter uses the collutory that the present invention relates to.Distribute the one in 2 kinds of collutory to experimenter, require to use the collutory of regulation to gargle, every day 2 times, each 20mL rinsing the mouth 30s.
Pre-antiplaque before and after folic acid collutory is used to form evaluation result
The plaque index Indexes Comparison of two groups of experimenters, when satisfied (matched group-test group)/matched group >=15%, illustrates that product has the effect of pre-antiplaque shape.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvement and modification, these improve and modification also should be considered as protection scope of the present invention.
Claims (3)
1., containing a collutory for folic acid, this collutory contains folic acid, zinc citrate, Mentholum, sodium ascorbate, sodium bicarbonate, sodium copper chlorophllin, potassium sorbate, sorbitol or sorbose, deionized water.
2. the collutory containing folic acid according to claim 1, is characterized in that: the mass fraction of each component is folic acid 0.2-2 part, zinc citrate 1-10 part, Mentholum 0.5-5 part, sodium ascorbate 2-8 part, sodium bicarbonate 0.1-3 part, sodium copper chlorophllin 0.01-0.2 part, potassium sorbate 3.5-8 part, sorbitol or sorbose 5-20 part, deionized water 945.80-988.69 part.
3. a preparation method for the collutory containing folic acid described in claim 1 or 2, this preparation method is: folic acid, Mentholum, sodium ascorbate, zinc citrate, sodium bicarbonate, sodium copper chlorophllin, potassium sorbate, sorbitol or sorbose and deionized water are produced by the method be uniformly mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410301551.1A CN105213211A (en) | 2014-06-30 | 2014-06-30 | A kind of collutory containing folic acid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410301551.1A CN105213211A (en) | 2014-06-30 | 2014-06-30 | A kind of collutory containing folic acid and preparation method thereof |
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| CN105213211A true CN105213211A (en) | 2016-01-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410301551.1A Pending CN105213211A (en) | 2014-06-30 | 2014-06-30 | A kind of collutory containing folic acid and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389205A (en) * | 2016-10-31 | 2017-02-15 | 广东科玮生物技术股份有限公司 | Mouthwash with sodium copper chlorophyllin |
| JP7526849B2 (en) | 2016-04-13 | 2024-08-01 | 第一三共ヘルスケア株式会社 | Composition containing a copper compound, a zinc compound, and L-menthol |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6746681B1 (en) * | 2002-12-20 | 2004-06-08 | Preventive Dental Specialties, Inc. | Pet tooth care preparation |
| CN102512334A (en) * | 2012-01-10 | 2012-06-27 | 广州薇美姿个人护理用品有限公司 | Oral care composition as well as oral care product containing same and preparation method of oral care composition |
-
2014
- 2014-06-30 CN CN201410301551.1A patent/CN105213211A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6746681B1 (en) * | 2002-12-20 | 2004-06-08 | Preventive Dental Specialties, Inc. | Pet tooth care preparation |
| CN102512334A (en) * | 2012-01-10 | 2012-06-27 | 广州薇美姿个人护理用品有限公司 | Oral care composition as well as oral care product containing same and preparation method of oral care composition |
Non-Patent Citations (2)
| Title |
|---|
| 王忠朝等: "叶酸与牙周病的关系", 《国际口腔医学杂志》 * |
| 章洁: "破骨细胞骨吸收上清液对MC3T3-E1细胞OPG、RANKL蛋白表达的实验研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7526849B2 (en) | 2016-04-13 | 2024-08-01 | 第一三共ヘルスケア株式会社 | Composition containing a copper compound, a zinc compound, and L-menthol |
| CN106389205A (en) * | 2016-10-31 | 2017-02-15 | 广东科玮生物技术股份有限公司 | Mouthwash with sodium copper chlorophyllin |
| CN106389205B (en) * | 2016-10-31 | 2017-07-25 | 广东科玮生物技术股份有限公司 | A kind of mouthwash containing sodium copper chlorophyllin |
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Effective date of registration: 20160316 Address after: 100176, No. 1, building 3, Cheng Cheng street, Beijing economic and Technological Development Zone, Beijing Applicant after: BEIJING SCRIANEN PHARMACEUTICAL CO., LTD. Address before: 100176 Daxing District Zhongguancun science and Technology Park Daxing biomedical industry base 0501-32-1 block Applicant before: BEIJING SCRIANEN PHARMACEUTICAL CO., LTD. |
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Application publication date: 20160106 |