CN105193638A

CN105193638A - Application of astaxanthin in toothpaste

Info

Publication number: CN105193638A
Application number: CN201510670308.1A
Authority: CN
Inventors: 左爱学; 张建英
Original assignee: Yunnan University of Traditional Chinese Medicine TCM
Current assignee: Yunnan University of Traditional Chinese Medicine TCM
Priority date: 2015-10-13
Filing date: 2015-10-13
Publication date: 2015-12-30

Abstract

The invention discloses an application of astaxanthin in toothpaste and relates to the technical field of toothpaste. In a toothpaste preparation technology, the astaxanthin is taken as an auxiliary medicine material with anti-inflammation and gingival atrophy resistance functions and added to the toothpaste. The astaxanthin is added in the preparation process of the toothpaste, is safe to use, has better curative effects on common oral diseases such as toothache, dental ulcer, gingivitis, gingival bleeding, gingival atrophy and the like, has remarkable functions of anti-inflammation, hemostasis and bacteriostasis and can eliminate peculiar smell of the oral cavity.

Description

The application of astaxanthin in toothpaste

Technical field

The present invention relates to technical field of toothpaste, be specifically related to the application of astaxanthin in toothpaste.

Background technology

Astaxanthin, also known as astaxanthin or 3,4,3',4'-tetraketo-.beta.-carotene, is the one of carotenoid, is a kind of stronger Natural antioxidant.The same with other carotenoid, astaxanthin belongs to a kind of fat-soluble and water miscible pigment, all can find in the marine organisms such as shrimp, Eriocheir sinensis, salmon, algae.Natural astaxanthin, as a kind of functional component, can be widely used in the various fields such as food, health food, medicine, cosmetics.In recent years, people are also probing into other useful performance of astaxanthin, and Hussein etc. (BiolPharmBull, 2005,28 (1): 47-52) prove that astaxanthin has significant neuroprotective.Lee etc. prove that astaxanthin can suppress the expression of the generation of inflammatory cytokine such as NO, PGE2 (PGE2), NO synthase (NOS), COX-2 (COX-2), tumor necrosis factor α (TNF-α) and interleukin-1 ' beta ' (1L-1 β) inducing action by experiment, it even can suppress the serum levels (MolCells of NO, PGE2, TNF-α and 1L-1 β, 2003,16 (1): 97-105).Mara company is by natural astaxanthin and compare with other 26 kinds famous anti-inflammatory drug effects, and the anti-inflammatory drug of in result display astaxanthin and investigation 92% has equal effect or higher; The OTC (over-the-counter) anti-inflammatory agent comprising aspirin with 62 kinds is compared, astaxanthin with wherein 76% medicine there is equal effect or better (TechnicalReportTR, 3005.001.1999).These results all illustrate that astaxanthin also has antiinflammation, and its antiinflammatory action can be used for the disease treating and prevent to be caused by inflammation.

Toothpaste is indispensable dental care products in people's daily life, and its basic function is cleaning teeth, fresh breath, reaches the object keeping oral cavity cleaning.In recent years, because consumer healthcare realizes continuous enhancing, more requirement being proposed to toothpaste, also add some auxiliary prevention oral diseases except cleaning one's teeth, oral cavity had to the function of nursing health effect.Mostly adopt various active ingredient of Chinese herbs as the ancillary drug of toothpaste in existing toothpaste, in these medicated toothpaste, some has plurality of Chinese composition, and producing process is complicated, although some producing process is simple but effect is general.

Summary of the invention

For the deficiencies in the prior art, the invention provides one and there is antiinflammatory, antibacterial, antioxidation, can be used for treating oral ulcer, gingivitis, the toothpaste of prevention gingival hemorrhage and gingival atrophy.

For realizing above object, the present invention is achieved by the following technical programs:

The application of astaxanthin in toothpaste, namely adds the ancillary drug raw material of astaxanthin as antiinflammatory, anti-gingival atrophy effect in toothpaste in the technique preparing toothpaste.

Preferably, the percentage composition of described astaxanthin in total mastic of toothpaste is 0.02-0.2%.

Beneficial effect: astaxanthin adds in toothpaste as active component by the present invention in the technique preparing toothpaste, not only use safety, and have good therapeutic effect to the disease such as toothache, oral ulcer, gingivitis, gingival hemorrhage, anti-gingival atrophy that oral cavity is common, there is obvious antiinflammatory, hemostasis, antibacterial, antioxidation, counteract oral malodour.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.、

Embodiment 1-5: the application of astaxanthin in toothpaste

Toothpaste constitutive material in embodiment 1-5 and mass percentage content are as following table:

The preparation method of toothpaste in embodiment 1-5:

Lotion of toothpaste can adopt the one-step method cream production technology of conventional medicine toothpaste to make: in temporary cylinder, drop into the liquid material such as pure water, sorbitol, propylene glycol measured; In pre-dispersed still, drop into the powder such as astaxanthin, saccharin sodium, carboxycellulose sodium, silicon dioxide, sodium lauryl sulphate, calcium hydrogen phosphate, carrageenan measured, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, drop into essence until cream processed after 50 minutes, close colloid mill, agitator, scraper successively after 10 minutes, vacuum breaker, stop vacuum pump, make after sampling detection is qualified.

Clinical trial:

1. xylol causes the antiinflammatory action of white mice ear corridor acute inflammation swelling

Choose healthy ♂ white mice 30, be divided into 3 groups at random: blank group, experimental group and matched group, often organize 10.During experiment, often organize two sides inside and outside white mice auris dextra corridor and all smear dimethylbenzene 0.1ml/ only to inflammation, left ear does not add process and does self-blank matched group.After smearing dimethylbenzene 1h, the white mice of blank group does not carry out any process, toothpaste 0.1g/ obtained in the white mice auris dextra corridor inflammation place uniform application embodiment 3 of experimental group, blank 0.1/, the toothpaste of white mice auris dextra corridor inflammation place uniform application of matched group.After 6 hours, put to death white mice, cut two ear corridors, wash away auris dextra corridor tested material sample, clean with dry cotton ball with normal saline, get two circle auricles with card punch at same position cutter, it is swelling value that auris dextra sheet weight deducts left auricle weight.Its empty group swelling value is 17.28mg, and experimental group swelling value is 11.73mg, and matched group is 16.97mg.Relatively can learn, astaxanthin toothpaste obviously suppresses and alleviates white mice ear corridor acute inflammation swelling caused by dimethylbenzene, thus can infer in toothpaste that adding astaxanthin has certain antiinflammatory action to oral inflammations such as gingivitiss.

2. the present invention adds the concrete case of application of astaxanthin toothpaste:

Select 100 examples to have the sufferer of gingivitis, gingival hemorrhage oral disease, wherein man 50 example, female 50 example, at 15 ~ 65 years old age, is divided into 2 groups at random: experimental group and matched group, often organizes 50 people.Wherein experimental group uses toothpaste obtained in embodiment 3, and matched group uses blank toothpaste.Experimental group and matched group all use identical toothbrush, morning every day, evening respectively to brush teeth once, and requirement level vibration method is brushed teeth, and the time is 2-3 minute, and the lotion of toothpaste of use is about 1-1.5cm.After one week, experimental group 50 people gingivitis has certain improvement, and gingiva color is normal and gingiva is full, and gingiva without swelling bleeding, and has no adverse reaction, and matched group then only has 5 people to take a favorable turn, all the other personnel's gingival swelling and pain, gingival hemorrhages, and 35 people's exacerbation of symptoms.

Case 1: female, 26 years old, symptom: gingival hemorrhage has one-year age, frequent swelling and aching of gum and time sense gingiva itch.Treatment: with toothpaste obtained in embodiment 3 sooner or later brush teeth each once, one week rear swelling and aching of gum and gingiva symptom of itching is eased, and within two weeks, rear gums healthy is without bleeding.

Case 2: man, 38 years old, symptom: suffer from gingivitis, have a toothache and gingiva kermesinus, gingival atrophy was not full.Treatment: sooner or later brushing teeth with toothpaste obtained in embodiment 3, each once rear symptom of having a toothache alleviated in one week, after adhering to brushing teeth one month, the full pinkiness of gingiva and be close to neck portion.

It should be noted that, in this article, the such as relational terms of first and second grades and so on is only used for an entity or operation to separate with another entity or operating space, and not necessarily requires or imply the relation that there is any this reality between these entities or operation or sequentially.And, term " comprises ", " comprising " or its any other variant are intended to contain comprising of nonexcludability, thus make to comprise the process of a series of key element, method, article or equipment and not only comprise those key elements, but also comprise other key elements clearly do not listed, or also comprise by the intrinsic key element of this process, method, article or equipment.When not more restrictions, the key element limited by statement " comprising ... ", and be not precluded within process, method, article or the equipment comprising described key element and also there is other identical element.

Above embodiment only in order to technical scheme of the present invention to be described, is not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.

Claims

1. the application of astaxanthin in toothpaste, namely adds the ancillary drug raw material of astaxanthin as antiinflammatory, anti-gingival atrophy effect in toothpaste in the technique preparing toothpaste.

2. the application of astaxanthin in toothpaste as claimed in claim 1, it is characterized in that, the percentage composition of described astaxanthin in total mastic of toothpaste is 0.02-0.2%.